The aim of this study is to investigate the effect of the MWM technique on pain, normal joint movement, proprioception and quality of life in patients with knee osteoarthritis (OA).

开始日期2024-05-06

申办/合作机构

Okan Universitesi

NCT06222151 / RecruitingN/AIIT

Recovering From Bariatric Surgery: the Effects of Early Initiated and Supervised Mobilization

The aim is to investigate the effect of early initiated and supervised mobilization continued after discharge as management of postoperative pain and recovery following obesity surgery, including patient experiences, pain coping, physical functionality and quality of life.

开始日期2024-04-22

申办/合作机构

Novo Nordisk A/S

ChiCTR2300075668 / Recruiting早期临床1期IIT

Oral nicotinamide ribose (NR) in allogeneic hematopoietic stem cell transplant donors to promote stem cell mobilization

开始日期2023-09-20

申办/合作机构-

100 项与干细胞动员相关的临床结果

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100 项与干细胞动员相关的转化医学

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0 项与干细胞动员相关的专利（医药）

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项与干细胞动员相关的文献（医药）

2023-12-01·Transfusion and Apheresis Science

The impact of diabetes mellitus on hematopoietic stem cell mobilization, a-single center cohort study

Article

作者: Keklik, Muzaffer ; Güven, Zeynep Tuğba ; Demir, Fatma ; Begendi, Nermin Keni ; Kaynar, Leylagül ; Çelik, Serhat ; Ünal, Ali

BACKGROUNDFactors such as age, underlying hematological disease, chemotherapy and radiotherapy used, and bone marrow infiltration may cause mobilization failure. Several preclinical observed that diabetes mellitus (DM) leads to profound remodeling of the hematopoietic stem cell (HSC) niche, resulting in the impaired release of HSCs. We aim to examine the effect of DM on HSC mobilization and to investigate whether there is a relationship between complications developing in the DM process and drugs used to treat DM and mobilization failure.METHODSIn Erciyes University Bone Marrow Transplantation Unit, 218 patients who underwent apheresis for stem cell mobilization between 2011 and 2021 were evaluated retrospectively. One hundred and nine patients had a diagnosis of DM, and 109 did not.RESULTSMobilization failure developed in 17 (15.6 %) of the patients in the DM group, while it developed in 7 (6.4 %) patients in the non-DM group (p = 0.03). CD34+ stem cell count was 8.05 (1.3-30.2) × 10⁶/kg in the DM group, while it was 8.2 (1.7-37.3) × 10⁶/kg in the other group (p = 0.55). There was no statistically significant relationship between glucose and hemoglobin A1c levels and the amount of CD34+ cells (p = 0.83 and p = 0.14, respectively). Using sulfonylurea was the only independent predictor of mobilization failure (OR 5.75, 95 % CI: 1.38-24.05, p = 0.02).CONCLUSIONDM should be considered a risk factor for mobilization failure. Further research is needed fully to understand the mechanisms underlying the mobilization failure effects of sulfonylureas and to develop strategies to improve stem cell mobilization in diabetic patients.

2022-08-18·Immunological Investigations3区 · 医学

Mitochondrial DNA as a Possible Ligand for TLR9 in Irinotecan-induced Small Intestinal Mucositis

3区 · 医学

Article

作者: Fagundes, Caio Tavares ; Soriani, Frederico Marianetti ; Menezes-Garcia, Zélia ; do Nascimento Arifa, Raquel Duque ; Souza, Daniele G. ; Teixeira, Mauro Martins ; Machado, Alexandre de Magalhães Vieira ; Ávila, Thiago Vinicius

Cancer chemotherapy and radiotherapy may result in mucositis characterized by stem cell damage and inflammation in the gastrointestinal tract. The molecular mechanisms underlying this pathology remain unknown. Based on the assumption that mitochondrial CPG-DNA (mtDNA) released and sensed by TLR9 could underlie mucositis pathology, we analyzed the mtDNA levels in sera as well as inflammatory and disease parameters in the small intestine from wild-type (WT) and TLR9-deficient mice (TLR9-/-) in an experimental model of intestinal mucositis induced by irinotecan. Additionally, we verified the ability of WT and TLR9-/- macrophages to respond to CpG-DNA in vitro. WT mice injected with irinotecan presented a progressive increase in mtDNA in the serum along with increased hematocrit, shortening of small intestine length, reduction of intestinal villus:crypt ratio and increased influx of neutrophils, which were followed by higher expression of Nlrp3 and Casp1 mRNA and increased IL-1β levels in the ileum when compared to vehicle-injected mice. TLR9-deficient mice were protected in all these parameters when compared to WT mice. Furthermore, TLR9 was required for the production of IL-1β and NO after macrophage stimulation with CpG-DNA. Overall, our findings show that the amount of circulating free CpG-DNA is increased upon chemotherapy and that TLR9 activation is important for NLRP3 inflammasome transcription and further IL-1β release, playing a central role in the development of irinotecan-induced intestinal mucositis. We suggest that TLR9 antagonism may be a new therapeutic strategy for limiting irinotecan-induced intestinal inflammation.

2022-01-01·Leukemia Research

Chronic eosinophilic leukemia with recurrent STAT5B N642H mutation—An entity with features of myelodysplastic syndrome/ myeloproliferative neoplasm overlap

Letter

作者: Sreedharanunni, Sreejesh ; Aravindan, Arun Vijayalakshmi ; Ahluwalia, Jasmina ; Singla, Shelly ; Singh, Namrata ; Jamwal, Manu ; Das, Reena ; Sharma, Ritika ; Rajpal, Sweta ; Balakrishnan, Anand ; Khadwal, Alka Rani ; Malhotra, Pankaj

A 13-yr-old male presented with insidious onset and progressive fatigue for more than three months duration.Investigations revealed severe anemia (Hb-51 g/L), thrombocytopenia (Platelet count-100 × 10⁹ /L), normal total leukocyte count (4.9 × 10⁹ /L) and eosinophilia (14%; absolute eosinophil count/AEC - 0.7 × 10⁹/l).To summarize, we report the first case of pediatric HES with STAT5B N642H from India highlighting the clin. and morphol. characteristics.The morphol. of STAT5B N642H pos. eosinophilia mimics stem cell syndromes; overlap with MDS as well as MPN and may show clonal T cells.STAT5B N642H is a potential diagnostic, prognostic and targetable marker and should be screened even in pediatric patients with eosinophilia but without an identifiable cause.