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更新于：2026-01-24
Tezacaftor
替扎卡托
更新于：2026-01-24
概要
基本信息
在研机构- |
权益机构- |
最高研发阶段无进展临床3期 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C26H27F3N2O6 |
InChIKeyMJUVRTYWUMPBTR-MRXNPFEDSA-N |
CAS号1152311-62-0 |
关联
20
项与 替扎卡托 相关的临床试验NCT06302270
Monitoring of Women and Children Exposed to the Combination of Elexacaftor-tezacaftor-ivacaftor During Bregnancy and Through Mother's Own Milk.
Observational study on women with Cystic Fibrosis treated with CFTR modulators during pregnancy and postpartum and their children. Registration on maternal health parameters and effects of CFTR-modulators in the newborn infant as well as effects of exposure through mother's own milk.
开始日期2024-03-15 |
申办/合作机构  Region Stockholm [+1] |
NCT06154447
A Phase 1, Study of VX-828 in Healthy Subjects and in Subjects With Cystic Fibrosis
The purpose of the study is to evaluate safety, tolerability, and pharmacokinetics of VX-828 and VX-828 in triple combination (TC) with Tezacaftor (TEZ)/ VX-118 or TEZ/ deutivacaftor (D-IVA) in healthy participants and VX-828 in combination with D-IVA with or without TEZ in participants with cystic fibrosis (CF).
开始日期2023-12-12 |
申办/合作机构 |
NCT05822102
Simultaneous quanTification of Elexacaftor/tezAcaftor/Ivacaftor Via Reverse Phase High Performance liquiD chromatographY
The purpose of this study is to support the clinical validation of a new assay to measure the levels of ivacaftor, tezacaftor, and elexacaftor (the components of Trikafta) in the bloodstream in order to achieve greater understanding of the effectiveness of this medication in all people with cystic fibrosis. Blood will be drawn at 3.0, 4.5, and 6.0 hours after taking the medication in the morning.
开始日期2023-02-09 |
申办/合作机构 |
100 项与 替扎卡托 相关的临床结果
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100 项与 替扎卡托 相关的转化医学
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100 项与 替扎卡托 相关的专利（医药）
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1,059
项与 替扎卡托 相关的文献（医药）2026-05-01·Respiratory Medicine and Research
Skin side-effects of elexacaftor-tezacaftor-ivacaftor: a real-world view
Article
作者: Sunil, Devika ; Phillips, Mirain ; Darby, Alice ; Constantinou, Sophie ; Webber, Lucy ; Goodwin, Richard ; Duckers, Jamie
BACKGROUND:
Since 2020, ETI (elexacaftor/tezacaftor/ivacaftor) has been used to treat patients with cystic fibrosis. Acne and rash are listed as "common" and "very common" adverse effects in the Summary of Product Characteristics for ETI, affecting between 2-5% and 10% of patients respectively. Patients have, however, shared their experience of developing acne and rashes with clinicians and on social media. This study aimed to describe the real-world impact of rash and acne amongst patients taking ETI and to evaluate the service provided by healthcare practitioners.
METHODS:
A paper and/or electronic survey was distributed to adult patients taking ETI in two regional CF centres between November 2022 and February 2023.
RESULTS:
Of the 268 survey respondents, 20.9% reported new-onset acne and 13.8% reported a rash following the commencement of ETI. 11.9% had a past history of acne and reported an exacerbation/recurrence after starting ETI. ETI-associated acne occurred weeks to months after commencement of ETI, whereas most rashes occurred within the first 2 weeks of treatment. Reassuringly for 2/3 of affected patients, acne and rashes were minor side effects, although 1/3 experienced a greater impact on their quality of life.
CONCLUSION:
This study is the first to specifically report the real-world prevalence of acne and rashes amongst patients taking ETI, which is higher than that reported in clinical trials. These findings could be used to improve counselling of patients commencing ETI. Ensuring access to up-to-date resources and treatments for patients experiencing skin side-effects would be mutually beneficial for both patients and healthcare professionals.
2026-03-01·ACTA PSYCHOLOGICA
Divergent neurobehavioral effects of CFTR modulators elexacaftor and ivacaftor in mice
Article
作者: Du, Jianyang ; Lu, Hui ; Reznikov, Leah R ; Fagan, Amy ; Ge, Qian
Recent advances in cystic fibrosis transmembrane conductance regulator (CFTR) modulator combination therapies have markedly improved survival and quality of life for people with cystic fibrosis (CF). Among these, the elexacaftor-tezacaftor-ivacaftor combination (Trikafta) and vanzacaftor-tezacaftor-deutivacaftor (Alyftrek), represent major therapeutic milestones. However, emerging reports suggest that Trikafta may contribute to anxiety and depression in some people with CF. In this study, we investigated the neurobehavioral effects of elexacaftor and ivacaftor in mice. Acute administration of elexacaftor elicited anxiety-like behavior, while ivacaftor induced depressive-like behavior. Additionally, we confirmed the presence of Cftr mRNA in the amygdala and hippocampus, brain regions implicated in anxiety and depression. These findings provide preclinical support for the reported mental health side effects experienced by some people with CF and offer new insights into CFTR function within the central nervous system, potentially guiding the development of future CF therapies with improved neuropsychiatric profiles.
2026-03-01·Journal of Orthopaedics
Decreased fracture risk in cystic fibrosis patients treated with CFTR modulator therapy
Article
作者: Horneff, John G ; Alsamhori, Jehad Feras ; Ashkar, Imad ; Boufadel, Peter ; Abboud, Joseph A ; Fiandeiro, Miguel ; Adio, Akin
Background:
Cystic fibrosis-related bone disease contributes substantially to fragility fractures and morbidity in patients with cystic fibrosis (CF). Cystic Fibrosis Transmembrane conductance Regulator (CFTR) modulators have been shown to improve pulmonary and nutritional outcomes, but their impact on skeletal health remains incompletely defined.
Methods:
We conducted a retrospective cohort study using the TriNetX Research Network, which aggregates deidentified electronic medical records from 168 health care organizations. Patients with CF who initiated CFTR modulators between 2012 and 2023 were compared with matched CF patients without modulator exposure. Sub-analyses examined outcomes in patients receiving elexacaftor/tezacaftor/ivacaftor (ETI) versus non-ETI modulators. A 1:1 propensity score matching algorithm balanced demographic and clinical covariates. The primary outcome was 2-year fracture risk. Relative risks (RR) with 95 % confidence intervals (CI) were calculated.
Results:
After matching, 5639 patients receiving CFTR modulators were compared with controls. Modulator therapy was associated with significantly reduced risk of overall fracture (RR 0.48, p < .0001), with protective effects observed for hand or wrist, forearm, upper limb, femur, lower leg, and vertebral fractures. Both ETI and non-ETI modulators were associated with significantly lower fracture risk compared with no therapy. There were no significant differences in fracture outcomes between ETI and non-ETI users.
Conclusion:
In this large, population-based analysis, CFTR modulator therapy was associated with lower 2-year fracture risk. These findings extend the benefits of modulator therapy beyond pulmonary and nutritional domains, highlighting its potential role in skeletal protection.
231
项与 替扎卡托 相关的新闻（医药）2026-01-24
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截至01月24日15点59分，近期共有 456 本期刊发布了 871 篇文章，其中糖尿病相关的文章共 325 篇，覆盖 30 个领域的内容。中国专家参与发表的文章有 77 篇。今日，影响因子最高的文章刊登在 Journal of the American Medical Association (IF: 55.000) 期刊上。
今日头条
Headlines
01 Ophthalmology IF: 09.500 替尔泊肽与降低糖尿病视网膜病变及相关并发症风险：一项美国多中心队列研究
Shah, Jaffer, Razavi, Peyman, Festok, Muhamad, Ahmed, Harris, Mahrous, M Abdallah, Kovacs, Kyle D, etc.
近日，一项发表于眼科权威期刊《Ophthalmology》的大型回顾性研究揭示了新型药物替尔泊肽（Tirzepatide）在糖尿病管理中可能带来的额外益处。该研究首次系统评估了替尔泊肽对糖尿病视网膜病变（DR）这一常见且严重的微血管并发症的长期影响。
研究团队利用覆盖广泛的TriNetX美国协作医疗数据库，开展了一项基于人群的回顾性队列分析。研究聚焦于患有糖尿病且伴有超重或肥胖状况的患者群体，旨在探究起始使用替尔泊肽与仅接受生活方式干预，在预防和延缓糖尿病视网膜病变方面是否存在差异。
研究设计严谨，为尽量减少混杂因素的影响，研究人员采用了倾向评分匹配的方法。他们将每位起始使用替尔泊肽的患者，与一位在人口统计学特征、代谢指标（如糖化血红蛋白、体重指数）以及系统性共病（如高血压、高血脂）等方面高度相似，但仅接受生活方式干预且未使用任何减重药物的患者进行配对。经过匹配，最终共有173,846名患者被纳入分析，平均年龄为56.9岁，其中女性占比52.0%，两组各包含86,923名患者，确保了比较的均衡性。
研究的主要观察终点是糖尿病视网膜病变的发生、向更严重阶段（如从非增殖性发展为增殖性）的进展，以及因视网膜病变而需要接受特定眼科干预的情况，例如玻璃体内注射抗血管内皮生长因子（抗-VEGF）药物或进行全视网膜激光光凝术。
经过为期12个月的随访，分析结果呈现出显著差异。与单纯依靠生活方式干预的对照组相比，使用替尔泊肽的患者发生各类糖尿病视网膜病变事件的风险普遍降低。具体数据显示，替尔泊肽组患者新发轻度非增殖性糖尿病视网膜病变的风险相对降低了约14%，进展为威胁视力的增殖性糖尿病视网膜病变的风险降低了约30%。
替尔泊肽在降低糖尿病视网膜病变相关严重并发症风险方面表现出更为明显的优势。研究结果显示，使用替尔泊肽的患者，发生合并有视力损害风险的糖尿病性黄斑水肿的风险降低了约38%，发生玻璃体积血的风险降低了约39%，而发生可能导致永久性视力丧失的牵拉性视网膜脱离的风险更是大幅降低了约63%。
这些风险的降低直接转化为临床干预需求的减少。数据分析表明，与对照组相比，替尔泊肽组患者在未来一年内需要接受玻璃体内抗-VEGF注射以治疗黄斑水肿或新生血管的风险降低了约52%，需要接受全视网膜激光光凝术以控制增殖性病变的风险降低了约39%。
综上所述，这项基于大规模真实世界数据的研究表明，对于患有糖尿病且超重或肥胖的患者，使用替尔泊肽治疗，与仅采取生活方式干预相比，可能与更低的糖尿病视网膜病变新发及进展风险相关联。此外，替尔泊肽的使用还可能显著降低因视网膜病变导致严重并发症的发生率，并减少患者后续接受侵入性眼科治疗的需求。这一发现为临床医生在制定糖尿病综合管理方案，特别是对于有视网膜病变风险的患者选择治疗方案时，提供了新的重要参考依据。
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Ophthalmology | Ahead of Print.
10.1016/j.ophtha.2026.01.013
02 JAMA Network Open IF: 09.700 互动虚拟助手对2型糖尿病老年患者健康促进的干预研究：IVAM-ED随机临床试验
Matzenbacher, Lucas S, da Costa, Frederico Ludwig, de Barros, Laura Gomes Boabaid, Gheno, Vicenzo, Maia, Isabela Semmelmann, Blank, Luiza Machado, etc.
一项最新发表的随机临床试验显示，一款基于智能音箱的互动虚拟助手，能够显著改善老年2型糖尿病患者的心理健康状况、生活质量、疾病自我管理行为以及血糖控制水平。该研究结果发表在JAMA Network Open期刊上。
该研究旨在探究技术设备结合行为干预模型，在支持老年糖尿病患者健康管理方面的潜力。研究指出，老年糖尿病患者常面临较高的心理困扰，这可能使疾病管理复杂化，并对健康结局产生负面影响。
该研究于2023年6月22日至2024年2月8日期间，在巴西的一家学术医疗中心开展。研究共纳入了112名年龄在65岁及以上、确诊为2型糖尿病的参与者，他们的平均年龄为72.5岁，平均糖化血红蛋白水平为7.9%。参与者被随机分为两组，干预组在家中使用了预编程的智能音箱设备（Amazon Echo Dot）12周，而对照组则继续接受常规医疗护理。
研究人员在12周的干预期结束后，对参与者的多项指标进行了评估。主要结局是心理困扰程度，采用自评问卷进行测量。结果显示，与常规护理组相比，使用智能音箱的干预组参与者的心理困扰评分显著更低，两组间的调整后平均差值为-1.46分，具有统计学意义。这表明该干预有效减轻了患者的心理困扰。
除了主要结局，研究还观察了一系列重要的次要结局。在生活质量方面，干预组比常规护理组有显著提升。在糖尿病自我护理行为的依从性上，干预组也表现出明显改善。更重要的是，在血糖控制的关键指标——糖化血红蛋白上，干预组比对照组平均降低了0.48%，达到了具有临床意义的改善水平。然而，在感知压力方面，两组之间未观察到显著差异。整个研究过程中，没有参与者因不良事件而退出试验。
该研究的结论表明，这种通过智能设备提供的、易于实施的行为干预，能够为老年2型糖尿病患者带来多方面的健康获益。它不仅有助于缓解患者的心理痛苦，还能促进其积极进行自我管理，并最终实现更好的血糖控制效果。这为在社区和家庭环境中推广数字化健康管理工具提供了新的证据。
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JAMA Network Open | Volume 9, Issue 1
10.1001/jamanetworkopen.2025.53508
03 Diabetes Technol Ther IF: 06.300 糖尿病吸入胰岛素应用者的肺癌与慢性阻塞性肺疾病真实世界发病率
Cowart, Kevin, Everich, Hannah, Flores, Francisco, Harris, Marisa, Randall, Daniel, Sammartano, Lauren, etc.
一项新近发表于《Diabetes technology & therapeutics》的研究，利用大规模真实世界数据，评估了吸入式胰岛素与速效胰岛素类似物在成年糖尿病患者中的肺部安全性，重点关注肺癌与慢性阻塞性肺疾病风险。该研究结果为临床决策提供了重要参考。
研究团队利用TriNetX网络数据库，回顾性地纳入了患有1型或2型糖尿病的成年患者。这些患者被分为两组：一组曾处方吸入式胰岛素，另一组则处方速效胰岛素类似物。为减少混杂因素的影响，研究者对两组人群进行了倾向性评分匹配，最终使两组在基线特征上具有可比性。
研究结果显示，在肺癌风险方面，两组患者未观察到统计学上的显著差异。具体而言，吸入式胰岛素组与速效胰岛素类似物组发生任何肺癌的风险比值为1，其95%置信区间为0.42至2.40，P值达到0.999，表明两组风险并无不同。
然而，在慢性阻塞性肺疾病方面，吸入式胰岛素组发生慢性阻塞性肺疾病复合结局的风险，显著高于速效胰岛素类似物组。风险比值为3.45，意味着前者的风险是后者的约3.5倍，且该差异具有高度的统计学意义。不过，研究者也指出，两组患者的绝对风险均处于较低水平。
基于这些发现，研究者得出结论：在这项真实世界研究中，未发现吸入式胰岛素的使用与肺癌风险增加之间存在关联。但同时，吸入式胰岛素与慢性阻塞性肺疾病风险的升高相关，尽管绝对风险较低。研究者强调，该关联的生物学合理性尚不明确，并非结论性的。
研究者同时指出了本研究的局限性。作为一项回顾性观察性研究，其设计本身可能受到混杂因素及信息偏倚（如监测偏倚）的影响，因此难以做出确切的因果推断。尽管如此，这些发现强调了继续监测和评估吸入式胰岛素长期肺部安全性的必要性。
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Diabetes Technol Ther | Ahead of Print.
10.1177/15209156251387102
中国发表（77）
China
BMC medicine IF: 08.300Ahead of Print.No.01Association of short-term exposure to ambient air pollutants with liver function and mediation by fasting insulin: evidence from a rural cohort in China短期暴露于环境空气污染物与肝功能的关联及空腹胰岛素的中介作用：来自中国农村队列的证据DOI: 10.1186/s12916-026-04645-x
npj science of food IF: 07.800Ahead of Print.No.02Cooked meat-derived extracellular vesicles ssc-miR-1 induces metabolic disorders in the mice liver via PI3k/AKT pathway烹饪肉食来源的细胞外囊泡ssc-miR-1通过PI3K/AKT通路诱导小鼠肝脏代谢紊乱DOI: 10.1038/s41538-026-00709-7
Am J Vet Res IF: 01.400Ahead of Print.No.03Hydroxyacyl coenzyme A dehydrogenase trifunctional multienzyme complex subunit α depletion dysregulates hepatic energy and lipid metabolism in dairy cows hepatocytes: a multiomic integration analysis羟酰基辅酶A脱氢酶三功能多酶复合体α亚基缺失扰乱奶牛肝细胞的能量与脂质代谢：一项多组学整合分析DOI: 10.2460/ajvr.25.09.0336
BMC endocrine disorders IF: 03.300Ahead of Print.No.04Calcitonin-negative medullary thyroid carcinoma combined with multifocal papillary thyroid carcinoma: a case report and literature review降钙素阴性甲状腺髓样癌合并多灶性甲状腺乳头状癌：一例报告并文献复习DOI: 10.1186/s12902-026-02172-7
BMC microbiology IF: 04.200Ahead of Print.No.05Faecal microbiome and serum metabolomics: potential biomarkers for type 2 diabetes粪便微生物组与血清代谢组学：2型糖尿病的潜在生物标志物DOI: 10.1186/s12866-025-04571-7
Nature reviews. Nephrology IF: 39.800Ahead of Print.No.06Effects of social determinants of health on the landscape of kidney disease健康的社会决定因素影响肾脏疾病图景DOI: 10.1038/s41581-026-01052-6
Int J Biol Macromol IF: 08.500Ahead of Print.No.07Pro-angiogenic dual-crosslinked collagen bioinks for precise cell-laden DLP 3D printing and rapid vascularized diabetic wound repair用于精确负载细胞DLP 3D打印和快速血管化糖尿病伤口修复的促血管生成双交联胶原生物墨水DOI: 10.1016/j.ijbiomac.2026.150408
Experimental Eye Research IF: 02.700Ahead of Print.No.08Elevated Expression of Hsa_circ_0053004 in Peripheral Blood Mononuclear Cells Correlates with Endothelial Dysfunction in Diabetic Retinopathy外周血单个核细胞中hsa_circ_0053004的表达升高与糖尿病视网膜病变中的内皮功能障碍相关DOI: 10.1016/j.exer.2026.110880
Life sciences IF: 05.100Ahead of Print.No.09Exogenous hydrogen sulphide alleviates diabetes-associated cognitive decline by inhibiting ferroptosis through Nrf2/GPX4 signalling pathway外源性硫化氢通过激活Nrf2/GPX4信号通路抑制铁死亡，缓解糖尿病相关认知衰退DOI: 10.1016/j.lfs.2026.124220
Colloids Surf B Biointerfaces IF: 05.600Ahead of Print.No.10A self-adapting DNA-crosslinked hydrogel reprograms macrophage polarization and angiogenesis for synergistic repair of diabetic wounds一种自适性DNA交联水凝胶通过重编程巨噬细胞极化与血管生成协同修复糖尿病伤口DOI: 10.1016/j.colsurfb.2026.115465
International dental journal IF: 03.700Ahead of Print.No.11Exploration Novel Therapeutic Targets for Periodontitis via Stress Granules Biomarkers通过应激颗粒生物标志物探索牙周炎的新型治疗靶点DOI: 10.1016/j.identj.2025.109390
Biomaterials advances IF: 06.000Ahead of Print.No.12A novel ROS switcher potentiates the type-I photodynamic effect of sodium zinc chlorophyllin against Pseudomonas aeruginosa in diabetic wounds一种新型活性氧转换开关可增强锌叶绿酸钠对糖尿病伤口中铜绿假单胞菌的I型光动力效应DOI: 10.1016/j.bioadv.2026.214721
Biomaterials advances IF: 06.000Ahead of Print.No.13Multifunctional conductive hydrogel integrating exosome delivery and electrical stimulation for enhanced diabetic wound healing整合外泌子递送与电刺激的多功能导电水凝胶促进糖尿病伤口愈合DOI: 10.1016/j.bioadv.2026.214716
J Nutr Health Aging IF: 04.000Ahead of Print.No.14An atlas of associations between dietary nutrients and the risk of 36 major chronic diseases膳食营养素与36种主要慢性病风险关联图集DOI: 10.1016/j.jnha.2026.100785
Obesity surgery IF: 03.100Ahead of Print.No.15Global Trends in Bariatric Surgery for the Treatment of Metabolic Syndrome: A Bibliometric and Visualization Analysis代谢综合征治疗中减重手术的全球趋势：A Bibliometric and Visualization AnalysisDOI: 10.1007/s11695-026-08489-5
Communications biology IF: 05.100Ahead of Print.No.16Obesity impairs spermatogenesis via Leydig cell ferroptosis induced by liver-derived exosomal miR-122-5p肥胖通过肝脏来源外泌体miR-122-5p诱导Leydig细胞铁死亡进而损害精子发生DOI: 10.1038/s42003-026-09612-z
npj science of food IF: 07.800Ahead of Print.No.17Computational-experimental study reveals direct target and bioactives of Ajania fruticulosa against NAFLD via TLR2/NF-κB/PPAR-γ signaling计算与实验研究揭示黄花蒿水提物通过TLR2/NF-κB/PPAR-γ信号通路对抗NAFLD的直接靶点与活性成分DOI: 10.1038/s41538-026-00722-w
Journal of Genetics and Genomics IF: 07.100Ahead of Print.No.18Lipid metabolism and metabolites: emerging roles in systemic physiology and metabolic diseases脂质代谢与代谢物：系统生理学与代谢疾病中的新兴作用DOI: 10.1016/j.jgg.2026.01.006
Experimental gerontology IF: 04.300Ahead of Print.No.19Association between weight-adjusted waist index (WWI) and multimorbidity: Evidence from NHANES and prospective validation in CHARLS体重调整腰围指数（WWI）与多重共病的关联：基于NHANES的证据及CHARLS的前瞻性验证DOI: 10.1016/j.exger.2026.113044
Bioorganic chemistry IF: 04.700Ahead of Print.No.20Design, synthesis and biological evaluation of hydroxycinnamoylamides derivatives as potent glucosidase inhibitors羟基肉桂酰胺衍生物作为强效葡萄糖苷酶抑制剂的设计、合成与生物学评价DOI: 10.1016/j.bioorg.2025.109453
Cell reports IF: 06.900Ahead of Print.No.21Lysosome-localized IRTKS condensates promote mTORC1 activity leading to MASLD and HCC溶酶体定位的IRTKS凝聚体通过激活mTORC1导致MASLD和HCCDOI: 10.1016/j.celrep.2025.116893
Curr Opin Gastroenterol IF: 02.500Ahead of Print.No.22Mechanistic insights into pancreatic duct pressure: from basic physiology to translational implications胰腺导管压力：从基础生理到转化应用的机制新见解DOI: 10.1097/MOG.0000000000001147
JMIR research protocols IF: 01.500Volume 15, Issue No.23Traditional Chinese Medicine Syndrome Differentiation of Adult Patients With Type 2 Diabetes and Metabolic Syndrome: Protocol for a Cross-Sectional Study成人2型糖尿病合并代谢综合征患者的中医证型鉴别：一项横断面研究方案DOI: 10.2196/86217
Biomolecules & biomedicine IF: 02.200Ahead of Print.No.24Prediabetes and the risk of incident chronic kidney disease in adults: A systematic review and meta-analysis成人糖尿病前期与慢性肾脏病发病风险：一项系统综述和荟萃分析DOI: 10.17305/bb.2026.13524
Reproduction IF: 03.700Volume 171, Issue 1No.25Deficiency of the GnIH/GPR147 system induces asthenozoospermia via PI3K-mediated metabolic and apoptotic dysregulationGnIH/GPR147系统缺陷通过PI3K介导的代谢与凋亡失调诱导弱精子症DOI: 10.1093/reprod/xaaf017
Reproduction IF: 03.700Ahead of Print.No.26High dietary fructose induces the senescence of granulosa cells by enhancing O-GlcNAcylation高果糖饮食通过增强O-GlcNAc糖基化诱导颗粒细胞衰老DOI: 10.1093/reprod/xaag005
Int J Mol Med IF: 05.800Volume 57, Issue 3No.27Research progress on the effects of macrophage‑derived exosomes on muscle factors IGF‑1 and FGF‑2 mediating musculoskeletal crosstalk molecular signaling pathway on bone metabolism (Review)巨噬细胞来源外泌体通过调节肌肉因子IGF-1和FGF-2介导肌肉骨骼互作信号通路影响骨代谢的研究进展（综述）DOI: 10.3892/ijmm.2026.5738
Molecular Medicine Reports IF: 03.500Volume 33, Issue 3No.28PDX1 in human cancers: Molecular mechanisms, dual roles and clinical implications (Review)PDX1在人类癌症中的作用：分子机制、双重角色及临床意义（综述）DOI: 10.3892/mmr.2026.13806
Annals of biomedical engineering IF: 05.400Ahead of Print.No.29T(2) Mapping at 3 T of Cartilage and Menisci in Patients with Diabetes Mellitus3T磁共振T2映射评估糖尿病患者的软骨与半月板DOI: 10.1007/s10439-026-03990-5
Science China. Life Sciences IF: 09.500Ahead of Print.No.30Lung function impairment and risk of sepsis and sepsis-related mortality: a large cohort study with over 310,000 participants肺功能损伤与脓毒症发生及脓毒症相关死亡风险：一项涵盖超31万人的大型队列研究DOI: 10.1007/s11427-025-3140-8
Molecular biology reports IF: 02.800Volume 53, Issue 1No.31UFMylation in lipid metabolism disorders-associated diseasesUFMylation在脂质代谢紊乱相关疾病中的作用DOI: 10.1007/s11033-026-11452-3
The FASEB journal : IF: 04.200Volume 40, Issue 2No.32Maternal Fructose Intake During Pregnancy Induced the Hepatic Glucose Homeostasis Imbalance in the Offspring by Inhibiting Glucokinase孕期母体果糖摄入通过抑制葡萄糖激酶诱发子代肝脏葡萄糖稳态失衡DOI: 10.1096/fj.202503081R
Biomaterials science IF: 05.700Ahead of Print.No.33A dual-network Bletilla striata polysaccharide hydrogel for PPAR-mediated macrophage polarization and accelerated diabetic wound healing一种基于PPAR介导的巨噬细胞极化加速糖尿病伤口愈合的双网络白及多糖水凝胶DOI: 10.1039/d5bm01617g
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.34Evaluating WHtR and WC cut-offs for abdominal obesity among children and adolescents: Insights from three National Surveys in China评估中国儿童青少年腹型肥胖的腰围身高比和腰围切点：基于三次全国学生体质与健康调研的启示DOI: 10.1111/dom.70488
Int J Mol Med IF: 05.800Volume 57, Issue 3No.35Mangiferin in human disease: Multifaceted mechanisms and applications (Review)芒果苷在人类疾病中的研究：多面机制与应用（综述）DOI: 10.3892/ijmm.2026.5736
Int J Mol Med IF: 05.800Volume 57, Issue 3No.36Epigenetic dysregulation of B‑cells in autoimmune diseases and lymphomas (Review)自身免疫性疾病和淋巴瘤中B细胞的表观遗传失调DOI: 10.3892/ijmm.2026.5739
Int J Mol Med IF: 05.800Volume 57, Issue 3No.37[Retracted] DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in ratsDDAH2通过激活DDAH/ADMA/NOS/NO通路减轻大鼠糖尿病心肌病的心肌纤维化DOI: 10.3892/ijmm.2026.5734
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.38Machine learning-based online prediction of nocturnal hypoglycemia in elderly patients with type 2 diabetes基于机器学习的老年2型糖尿病患者夜间低血糖在线预测DOI: 10.3389/fendo.2025.1685969
Int J Ophthalmol IF: 01.800Volume 19, Issue 2No.39Detecting altered spontaneous activities of different brain areas in diabetic vitreous hemorrhage patients: a magnetic resonance imaging study应用磁共振成像探测糖尿病玻璃体积血患者不同脑区的自发性活动改变DOI: 10.18240/ijo.2026.02.09
Journal of clinical ultrasound : IF: 01.400Ahead of Print.No.40Analysis of Risk Factors for Patency Rate After Ultrasound-Guided PTA for AVF Stenosis超声引导PTA治疗AVF狭窄后通畅率的风险因素分析DOI: 10.1002/jcu.70190
Advances in wound care IF: 05.600Ahead of Print.No.41Efficacy and Safety of Human Amniotic Membrane for Chronic Wounds: A Systematic Review and Meta-Analysis of Clinical Trials人羊膜治疗慢性伤口的有效性与安全性：一项临床试验的系统回顾与荟萃分析DOI: 10.1177/21621918251411808
Lipids in health and disease IF: 04.200Volume 25, Issue 1No.42Risk prediction of multiple cardiometabolic diseases in middle-aged and older adults using lipid metabolism biomarkers and derived composite measures based on machine learning: a prospective cohort study of CHARLS基于机器学习，利用脂质代谢标志物及其衍生复合指标预测中老年人心血管代谢共病的风险：CHARLS前瞻性队列研究DOI: 10.1186/s12944-025-02820-2
Frontiers in immunology IF: 05.900Volume 16, Issue No.43Correction: The role of immune cells-mediated memory in weight cycling, glucose disorders and insulin resistance更正：免疫细胞介导的记忆在体重循环、血糖紊乱及胰岛素抵抗中的作用DOI: 10.3389/fimmu.2025.1773368
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.44Cangfu Daotan decoction treats PCOS-IR through the IL6/JAK2/STAT3/FOXO4 signaling pathway苍附导痰汤通过IL6/JAK2/STAT3/FOXO4信号通路治疗多囊卵巢综合征胰岛素抵抗DOI: 10.3389/fendo.2025.1661000
Frontiers in nutrition IF: 05.100Volume 12, Issue No.45Assessing the potency of vitamin D augmentation on saccharometric indices in type 2 diabetes: a meta-analysis评估维生素D补充对2型糖尿病血糖指标的效能：一项Meta分析DOI: 10.3389/fnut.2025.1677686
Frontiers in nutrition IF: 05.100Volume 12, Issue No.46Metabolism, senescence, and natural products: new perspectives on wound healing in diabetes代谢、衰老与天然产物：糖尿病伤口愈合的新视角DOI: 10.3389/fnut.2025.1746827
Mini Rev Med Chem IF: 03.300Ahead of Print.No.47Bitter Compounds as Multifunctional Agents against Diabetes-associated Cognitive Dysfunction: Bridging Metabolic Regulation and Neuroprotection苦味化合物作为抗糖尿病相关认知功能障碍的多功能药物：连接代谢调控与神经保护DOI: 10.2174/0113895575414424251128113543
Can J Neurol Sci IF: 02.200Ahead of Print.No.48Peripheral Indicators of Alzheimer's Disease Pathology in Women With Polycystic Ovary Syndrome: A Case-Control Study多囊卵巢综合征女性阿尔茨海默病病理的外周指标：一项病例对照研究DOI: 10.1017/cjn.2025.10495
Front Mol Biosci IF: 04.000Volume 12, Issue No.49Research progress on oral glucagon-like peptide-1 receptor agonists in the treatment of diabetes mellitus type 2口服胰高血糖素样肽-1受体激动剂在2型糖尿病治疗中的研究进展DOI: 10.3389/fmolb.2025.1729904
FCVM IF: 02.900Volume 12, Issue No.50Machine learning-based prediction model for 30-day readmission risk in elderly patients with type 2 diabetes mellitus and heart failure: a retrospective cohort study with SHAP interpretability analysis基于机器学习的老年2型糖尿病合并心力衰竭患者30天再入院风险预测模型：一项结合SHAP可解释性分析的回顾性队列研究DOI: 10.3389/fcvm.2025.1673159
Frontiers in nutrition IF: 05.100Volume 12, Issue No.51Effect of preoperative oral isomaltulose on insulin resistance and glycemic variability in patients with type 2 diabetes mellitus: a randomized controlled trial术前口服异麦芽酮糖对2型糖尿病患者胰岛素抵抗及血糖变异性的影响：一项随机对照试验DOI: 10.3389/fnut.2025.1718843
Current diabetes reviews IF: 01.900Ahead of Print.No.52Chain Mediating Role of Illness Perception and Fear of Hypoglycemia in Impaired Hypoglycemic Awareness and Mild Cognitive Impairment in Patients with Type 2 Diabetes Mellitus疾病感知和低血糖恐惧在2型糖尿病患者低血糖感知受损与轻度认知障碍间的链式中介作用DOI: 10.2174/0115733998418191251127053922
Current diabetes reviews IF: 01.900Ahead of Print.No.53Targeting the Gut Microbiota in the Treatment of Type 2 Diabetes: Dietary Interventions, Microbial Preparations, and Fecal Transplantation靶向调控肠道菌群治疗2型糖尿病：饮食干预、微生物制剂与粪菌移植DOI: 10.2174/0115733998411102251127094217
Endocr Metab Immune Disord Drug Targets IF: 02.000Ahead of Print.No.54Gamma-Glutamyl Transferase and Male Reproductive Hormone Levels in Men with Type 2 Diabetes: A Cross-Sectional Studyγ-谷氨酰转移酶与2型糖尿病男性患者的生殖激素水平：一项横断面研究DOI: 10.2174/0118715303392699251016073511
Frontiers in nutrition IF: 05.100Volume 12, Issue No.55Mapping the evolution of botanical interventions for diabetic neuropathy: a two-database bibliometric landscape from 2005 to mid-2025映射植物干预糖尿病神经病变的演进：一项2005年至2025年中期的双数据库文献计量学图景DOI: 10.3389/fnut.2025.1727582
Andrology IF: 03.400Ahead of Print.No.56Comprehensive Quantification of Oligoasthenozoospermia Induced by Obesity, Reproductive Toxicants, and Their Combination in Rat Models大鼠模型中肥胖、生殖毒物及其组合诱导的少弱精子症的综合量化研究DOI: 10.1111/andr.70171
Journal of food science IF: 03.400Volume 91, Issue 1No.57Study on Anti-Obesity Activities of Three Individual Black Soybean Meal-Derived Insoluble Dietary Fibers via Modulating Intestinal Microbiota and Their Metabolites通过调节肠道微生物群及其代谢物研究三种黑豆粕不溶性膳食纤维的抗肥胖活性DOI: 10.1111/1750-3841.70778
Frontiers in immunology IF: 05.900Volume 16, Issue No.58Bioactives and exercise synergize to modulate AMPK and inflammation生物活性物质与运动协同调节AMPK及炎症DOI: 10.3389/fimmu.2025.1670379
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.59Impact of BMI on basal LH in premenarcheal girls with idiopathic central precocious puberty体重指数对月经初潮前特发性中枢性性早熟女童基础促黄体生成素的影响DOI: 10.3389/fendo.2025.1740527
Current pharmaceutical design IF: 02.800Ahead of Print.No.60Nuciferine Prevents Obesity by Inhibiting Macrophage Inflammation Involving LGALS3, CTSB, and RBP4 Genes Based on an Integrative Analysis of Adipose Tissue Transcriptomics and Network Pharmacology基于脂肪组织转录组学与网络药理学整合分析发现荷叶碱通过靶向LGALS3、CTSB和RBP4基因抑制巨噬细胞炎症进而预防肥胖DOI: 10.2174/0113816128400528251121074807
FCVM IF: 02.900Volume 12, Issue No.61Combining triglyceride glucose-body mass index and high-sensitivity C-reactive protein to predict cardiovascular disease: results from a national cohort and a clinical verified cohort联合甘油三酯葡萄糖-体重指数和高敏C反应蛋白预测心血管疾病：来自一项全国队列和一项临床验证队列的结果DOI: 10.3389/fcvm.2025.1726615
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.62Comparison of the efficacy of antidiabetic agents in type 2 diabetes with MASLD: a network meta-analysis降糖药物治疗2型糖尿病合并代谢功能障碍相关脂肪性肝病有效性的网络Meta分析比较DOI: 10.3389/fendo.2025.1659740
Medical acupuncture IF: 00.800Volume 37, Issue 5No.63Efficacy of Abdominal Acupoints Catgut Embedding Combined with Auricular Acupressure Therapy for Abdominal Obesity: A Single-Blind Randomized Control Trial腹部穴位埋线联合耳穴压豆疗法治疗腹型肥胖的有效性：一项单盲随机对照试验DOI: 10.1089/acu.2024.0014
Diabetes Technol Ther IF: 06.300Ahead of Print.No.64Performance of the Fifth Generation of a 16-Day Continuous Glucose Monitoring System in Adults with Diabetes第五代16天连续葡萄糖监测系统在成人糖尿病患者中的性能表现DOI: 10.1177/15209156261416870
CNS Neurol Disord Drug Targets IF: 03.000Ahead of Print.No.65The Use of Benzodiazepines and Risk of Incident Type 2 Diabetes in the General Population with Insomnia在患有失眠症的普通人群中使用苯二氮䓬类药物与2型糖尿病风险的研究DOI: 10.2174/0118715273430289251128102145
Frontiers in medicine IF: 03.000Volume 12, Issue No.66Solving the diagnostic dilemma in bone infections: metagenomic next generation sequencing enhances pathogen identification accuracy破解骨感染诊断困境：宏基因组二代测序提升病原体识别准确性DOI: 10.3389/fmed.2025.1699607
Front Clin Diabetes Healthc IF: 02.200Volume 6, Issue No.67Electrical stimulation: a novel adjunct therapy for diabetic foot ulcers电刺激：糖尿病足溃疡的新型辅助疗法DOI: 10.3389/fcdhc.2025.1682871
Frontiers in public health IF: 03.400Volume 13, Issue No.68Knowledge of diabetes among nurses of primary healthcare facilities in China: a cross-sectional survey study中国基层医疗机构护士糖尿病知识水平：一项横断面调查研究DOI: 10.3389/fpubh.2025.1717127
Front Mol Biosci IF: 04.000Volume 12, Issue No.69Effect of treatment duration on the associations between three modern antidiabetic drugs and survival outcomes of lung cancer in China三类新型抗糖尿病药物治疗时长对中国肺癌患者生存结局的影响DOI: 10.3389/fmolb.2025.1701515
Frontiers in surgery IF: 01.800Volume 12, Issue No.70Risk factors for sacrococcygeal pilonidal sinus: a systematic review and meta-analysis supplemented by genetic causal assessment骶尾部藏毛窦的风险因素：系统回顾、荟萃分析及遗传因果评估补充DOI: 10.3389/fsurg.2025.1718589
Journal of diabetes research IF: 03.400Volume 2026, Issue No.71Yixiao Formula Suppresses Myocardial Fibrosis Through UpregulatingmiR-133a and Downregulating TGF-β/Smads Signal Molecules益消方通过上调miR-133a和下调TGF-β/Smads信号分子抑制心肌纤维化DOI: 10.1155/jdr/5533249
Hematology IF: 01.600Volume 31, Issue 1No.72Effect of autoimmune diseases on aplastic anemia: a bidirectional two-sample Mendelian randomization study自身免疫性疾病对再生障碍性贫血的影响：一项双向两样本孟德尔随机化研究DOI: 10.1080/16078454.2026.2617680
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.73Deep exploration and precise identification of key risk factors for diabetic peripheral neuropathy using the random forest algorithm运用随机森林算法深入探索并精准识别糖尿病周围神经病变的关键风险因素DOI: 10.3389/fendo.2025.1740545
International journal of surgery IF: 10.100Volume 112, Issue 1No.74The C-reactive protein-triglyceride glucose index (CTI) predicts mortality in cardiovascular-kidney-metabolic syndrome: a dual-cohort study with machine learning validationC反应蛋白-甘油三酯-葡萄糖指数 (CTI) 预测心血管-肾脏-代谢综合征死亡率：一项结合机器学习验证的双队列研究DOI: 10.1097/JS9.0000000000003560
Frontiers in immunology IF: 05.900Volume 16, Issue No.75Multi-omics analysis of the potential association between metabolic features of hypothyroidism in the first half of pregnancy and Th17/Treg balance基于多组学分析探讨妊娠前半期甲状腺功能减退的代谢特征与Th17/Treg平衡的潜在关联DOI: 10.3389/fimmu.2025.1656946
Endocr Metab Immune Disord Drug Targets IF: 02.000Ahead of Print.No.76Association of Fibrinogen-Like Protein 1 with Metabolic Disorders and Pregnancy Outcomes: A Case-Control Study纤维蛋白原样蛋白1与代谢紊乱及妊娠结局的关联：一项病例对照研究DOI: 10.2174/0118715303416614251106110927
J Cachexia Sarcopenia Muscle IF: 09.100Volume 17, Issue 1No.77Multi-Omics Revealed the Effects of Intrauterine Hyperglycemia Exposure on the Development of Skeletal Muscle in Offspring多组学揭示宫内高血糖暴露对子代骨骼肌发育的影响DOI: 10.1002/jcsm.70177
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Diabetologia IF: 10.200Ahead of Print.No.07Glycaemic, appetite and circadian benefits of a dairy-enriched diet with high-protein breakfast and early daytime-restricted carbohydrate intake in type 2 diabetes: a randomised crossover trial富含奶制品的饮食搭配高蛋白早餐和日间早期限制碳水化合物摄入为2型糖尿病带来血糖、食欲和昼夜节律获益：一项随机交叉试验DOI: 10.1007/s00125-025-06658-2
British dental journal IF: 02.300Volume 240, Issue 2No.08Non-sugar sweeteners - too sweet to be true?非糖甜味剂——真的甜到好处吗？DOI: 10.1038/s41415-025-9252-8
Clinical therapeutics IF: 03.600Ahead of Print.No.09Study of Insulin Treatment Modalities in Adults With Cystic Fibrosis-Related Diabetes After Elexacaftor-Tezacaftor-Ivacaftor TherapyElexacaftor-Tezacaftor-Ivacaftor治疗后成人囊性纤维化相关糖尿病患者胰岛素治疗模式研究DOI: 10.1016/j.clinthera.2025.12.016
Pathology IF: 03.000Ahead of Print.No.10Screening for multiple myeloma has low yield as part of a secondary osteoporosis screen作为继发性骨质疏松症筛查的一部分，多发性骨髓瘤筛查的检出率较低DOI: 10.1016/j.pathol.2025.11.004
Evidence-based nursingAhead of Print.No.11Tailored, resource-aware implementation is crucial for sustainable diabetes prevention in primary care初级保健中可持续糖尿病预防的关键在于定制化且资源意识强的实施DOI: 10.1136/ebnurs-2025-104430
Advances in geneticsVolume 115, Issue No.12The JAK-STAT signaling pathway in inflammatory and autoimmune diseases: Its potential role as a therapeutic targetJAK-STAT信号通路在炎症与自身免疫性疾病中的作用及其作为治疗靶点的潜力DOI: 10.1016/bs.adgen.2025.11.008
Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Volume 73, Issue 1No.13Recent advances in pituitary tumors following the 2022 WHO classification2022年WHO分类发布后的垂体肿瘤研究新进展DOI: 10.1016/j.endien.2026.501747
Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Volume 73, Issue 1No.14Radioactive iodine-induced esophagitis: A rare complication放射性碘诱发的食管炎：一种罕见并发症DOI: 10.1016/j.endien.2025.501656
Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Volume 73, Issue 1No.15Vitamin K in home parenteral nutrition: Is it really necessary?家庭肠外营养中的维生素K：真的必要吗？DOI: 10.1016/j.endien.2025.501655
Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Volume 73, Issue 1No.16Enhancing levothyroxine dosing accuracy post-total thyroidectomy using body fat percentage利用体脂百分比提高全甲状腺切除术后左甲状腺素剂量准确性DOI: 10.1016/j.endien.2025.501645
J Stroke Cerebrovasc Dis IF: 01.800Ahead of Print.No.17Early Insights from a Multi-Centre National Stroke Surveillance Initiative in Tanzania坦桑尼亚多中心国家卒中监测倡议的早期发现DOI: 10.1016/j.jstrokecerebrovasdis.2026.108571
Toxicol Appl Pharmacol IF: 03.400Ahead of Print.No.18Sustained cadmium exposure and hyperglycemia additively drives mitochondrial dysfunction in hepatic cells: Implications for MASLD etiopathogenesis持续镉暴露与高血糖协同加剧肝细胞线粒体功能障碍：对MASLD发病机制的启示DOI: 10.1016/j.taap.2026.117729
Am J Clin Nutr IF: 06.900Ahead of Print.No.19Metabolome contribution to sex differences in the link between alcohol consumption and type 2 diabetes: a prospective analysis in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)代谢组对饮酒与2型糖尿病关联中性别差异的贡献：一项基于 Hispanic Community Health Study/Study of Latinos (HCHS/SOL)的前瞻性分析DOI: 10.1016/j.ajcnut.2026.101203
Clinical nutrition ESPEN IF: 02.600Ahead of Print.No.20Reply - Letter to the editor: Impact of fish oil-enriched high protein peptide-based formula on free fatty acid profiles and metabolomic changes in home enterally fed patients: A pilot study回复—致编辑的信：富含鱼油的高蛋白肽基配方对居家肠内营养患者游离脂肪酸谱及代谢组学变化的影响：一项初步研究DOI: 10.1016/j.clnesp.2026.102923
Clin Gastroenterol Hepatol IF: 12.000Ahead of Print.No.21Reply to : "Is baseline MASH fibrosis the key determinant for survival after bariatric surgery ?"回应：“基线MASH纤维化是减重手术后生存预后的关键决定因素吗？”DOI: 10.1016/j.cgh.2026.01.006
J Foot Ankle Surg IF: 01.300Ahead of Print.No.22Two-Dimensional vs Three-Dimensional Analysis of Weightbearing Charcot Neuropathy Deformities负重夏科氏神经关节病畸形的二维与三维分析对比DOI: 10.1053/j.jfas.2026.01.010
Environment international IF: 09.700Ahead of Print.No.23Longitudinal associations of long-term exposure to ambient air pollution, residential greenness, and air temperature with type 2 diabetes subphenotypes: Results from the KORA cohort study长期环境空气污染、住宅绿化及气温暴露与2型糖尿病亚型纵向关联研究：来自KORA队列研究的结果DOI: 10.1016/j.envint.2025.110043
Hormones and behavior IF: 02.400Ahead of Print.No.24Early androgens and development of social personality traits: Evidence from classical congenital adrenal hyperplasia早期雄激素与社交人格特质发展：来自经典先天性肾上腺增生症的证据DOI: 10.1016/j.yhbeh.2025.105875
Journal of pediatric nursing IF: 02.300Ahead of Print.No.25Adolescents' experiences of hypoglycemic episodes in type 1 diabetes青少年1型糖尿病患者的低血糖发作体验DOI: 10.1016/j.pedn.2026.01.023
Pediatric neurology IF: 02.100Ahead of Print.No.26The Relationship of Serum Uric Acid With Neurocognitive Functions in Children and Adolescents With Mild to Moderate Chronic Kidney Disease血清尿酸水平与轻度至中度慢性肾脏病儿童及青少年神经认知功能的关系DOI: 10.1016/j.pediatrneurol.2025.12.024
British journal of anaesthesia IF: 09.200Ahead of Print.No.27Perioperative management of patients taking glucagon-like peptide-1 receptor agonists: implementation of complex fasting recommendations. Response to Br J Anaesth 2025; 136: 375-6围手术期管理使用胰高血糖素样肽-1受体激动剂的患者：实施复杂禁食建议——对 Br J Anaesth 2025; 136: 375-6 的回应DOI: 10.1016/j.bja.2025.12.022
Fertility and sterility IF: 07.000Ahead of Print.No.28The Reproductive Tract Microbiome and Female Fertility: Dysbiosis, Disease Links, and Emerging Therapeutic Strategies生殖道微生物群与女性生育力：菌群失调、疾病关联及新兴治疗策略DOI: 10.1016/j.fertnstert.2026.01.010
Wiener klinische Wochenschrift IF: 02.100Ahead of Print.No.29Determination of the relationship between mothers' carbohydrate counting knowledge and glycemic control in children with type 1 diabetes母亲碳水化合物计数知识与儿童1型糖尿病血糖控制关系的研究DOI: 10.1007/s00508-025-02696-3
Placenta IF: 02.500Ahead of Print.No.30Structural alterations in the placental villous tree in well-controlled gestational diabetes mellitus控制良好的妊娠期糖尿病中胎盘绒毛树的结构改变DOI: 10.1016/j.placenta.2026.01.010
Comput Biol Chem IF: 03.100Ahead of Print.No.31Tailored pyrrole-based imidazothiazole scaffolds: Synthetic elaboration, enzyme kinetic profiling and DFT-guided molecular docking toward Antidiabetic therapeutics设计合成的吡咯基咪唑并噻二唑骨架：合成拓展、酶动力学分析及基于DFT的分子对接用于抗糖尿病治疗DOI: 10.1016/j.compbiolchem.2026.108920
Am J Vet Res IF: 01.400Ahead of Print.No.32Oral gabapentin reduces respiratory rate and resistance scores in adult domestic pigeons (Columba livia domestica) during and after handling口服加巴喷丁降低成年家鸽（Columba livia domestica）在操作期间及操作后的呼吸频率与抵抗评分DOI: 10.2460/ajvr.25.11.0401
J Gen Intern Med IF: 04.200Ahead of Print.No.33Gender Differences in Statin Discontinuation and Adherence Among Privately Insured People with HIV in the USA美国有私人保险的HIV感染者中他汀类药物停用与依从性的性别差异DOI: 10.1007/s11606-025-10164-x
Res Social Adm Pharm IF: 02.800Ahead of Print.No.34Assessing the impact of frailty on statin prescriptions among older stroke survivors with and without diabetes评估虚弱对老年卒中幸存者他汀类处方的影响：糖尿病与非糖尿病患者的比较DOI: 10.1016/j.sapharm.2026.01.004
J Gen Intern Med IF: 04.200Ahead of Print.No.35Subtle Laboratory and Clinical Precursors of Celiac Disease in Young Adults: A Large-Scale Retrospective Cohort Study年轻成人乳糜泻的细微实验室与临床先兆：一项大规模回顾性队列研究DOI: 10.1007/s11606-026-10187-y
BMC public health IF: 03.600Ahead of Print.No.36Evaluation of the experience of people referred under the NHS enhanced service incentive for obesity to the NHS digital weight management programme: a mixed method study对经NHS肥胖管理增强服务激励计划转诊至NHS数字体重管理项目者的体验评估：一项混合方法研究DOI: 10.1186/s12889-026-26203-z
Canadian journal of anaesthesia IF: 03.300Ahead of Print.No.37Characteristics of the epidural electrical stimulation test and pressure waveform test to confirm epidural catheter placement in patients who are pregnant and have a body mass index higher than 50 kg·m(-2)体重指数高于50 kg·m(-2)孕妇中硬膜外电刺激测试与压力波形测试确认硬膜外导管放置的特征DOI: 10.1007/s12630-025-03062-7
The AAPS journal IF: 03.700Volume 28, Issue 2No.38Pharmacokinetics of Inhibitors of Succinyl-CoA:3-Ketoacid CoA Transferase in Sprague-Dawley Rats, and the Effect of a High-Fat DietSprague-Dawley大鼠中琥珀酰辅酶A：3-酮酸辅酶A转移酶抑制剂的药代动力学及高脂饮食的影响DOI: 10.1208/s12248-026-01208-z
European journal of pediatrics IF: 02.600Volume 185, Issue 2No.39Influence of weight perception on the evolution of body composition of adolescents under obesity treatment体重感知对接受肥胖治疗的青少年身体成分演变的影响DOI: 10.1007/s00431-025-06737-x
Surg Obes Relat Dis IF: 03.800Ahead of Print.No.40Left ventricular assist devices triple the risk of serious complications and longer hospital stay following bariatric surgery: a national analysis of 180,544 Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program cases左心室辅助装置使减重术后严重并发症风险增加三倍，并延长住院时间：基于180,544例MBSAQIP病例的国家数据分析DOI: 10.1016/j.soard.2025.12.003
Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Volume 73, Issue 1No.41Beyond vectorial bioelectrical impedance: Assessing body composition changes with novel electrical parameters in obese osteoarthritis patients on a meal-replacement diet超越矢量生物电阻抗：利用新型电学参数评估肥胖骨关节炎患者进行代餐饮食后的身体成分变化DOI: 10.1016/j.endien.2025.501644
BMJ open IF: 02.300Volume 16, Issue 1No.42Evaluation of an innovative family-centred care and prevention intervention for children with overweight and obesity: a mixed-methods study protocol of the randomised controlled fruehstArt study in Germany德国fruehstArt随机对照研究：一项针对超重和肥胖儿童的创新性以家庭为中心的照护与预防干预的评估——一项混合方法研究方案DOI: 10.1136/bmjopen-2025-111373
Biochim Biophys Acta Gene Regul Mech IF: 03.100Ahead of Print.No.43Tet2-mediated Pref-1 activation delays adipocyte differentiationTet2介导的Pref-1激活延迟脂肪细胞分化DOI: 10.1016/j.bbagrm.2026.195137
Contraception IF: 02.300Ahead of Print.No.44Evaluating Graduating OBGYN Residents' Training in Postpartum Permanent Contraceptive Procedures评估即将毕业的妇产科住院医师产后永久避孕手术的培训情况DOI: 10.1016/j.contraception.2026.111372
Revista cli?nica espan?olaAhead of Print.No.45Position statement of the spanish society of internal medicine (SEMI) and the portuguese society of internal medicine (SPMI)西班牙内科医学会与葡萄牙内科医学会立场声明DOI: 10.1016/j.rceng.2026.502468
World neurosurgery IF: 02.100Ahead of Print.No.46Body Mass Index as A risk Factor for Recurrence and Frequency of Re-surgery After Lumbar Spine Surgery体重指数作为腰椎手术后复发及再手术频率的风险因素DOI: 10.1016/j.wneu.2026.124824
Journal of nutrition IF: 03.800Ahead of Print.No.47Integrative Nutrigenomics Approach in Polycystic Ovarian Syndrome: Targeting Gene-Diet Interactions for Personalized Nutraceutical Interventions多囊卵巢综合征的整合营养基因组学方法：靶向基因-饮食相互作用实现个性化营养干预DOI: 10.1016/j.tjnut.2026.101371
Journal of nutrition IF: 03.800Ahead of Print.No.48Chemical Analysis of Controlled Diets High in and Free of Ultra-processed Foods (UPF) and Proof-of-Concept Findings: Reducing UPF Consumption May Lower Diabetes Risk in Mid-life Adults高含量与零含量超加工食品的控制饮食化学分析及概念验证发现：减少超加工食品摄入或可降低中年成人糖尿病风险DOI: 10.1016/j.tjnut.2026.101370
Molecular metabolism IF: 06.600Ahead of Print.No.49α-Parvin Promotes Glucose Uptake and Metabolism in Skeletal Muscle with Minimal Influence on Hepatic Insulin Sensitivityα-Parvin促进骨骼肌葡萄糖摄取与代谢，对肝脏胰岛素敏感性影响甚微DOI: 10.1016/j.molmet.2026.102322
Cell reports IF: 06.900Ahead of Print.No.50Integrative multi-omics analysis reveals oral microbiome-metabolome signatures of obesity整合多组学分析揭示肥胖的口腔微生物组-代谢组特征DOI: 10.1016/j.celrep.2025.116819
Cell reports medicine IF: 10.600Ahead of Print.No.51Gut microbiome and obesity care: Bridging dietary, surgical, and pharmacological interventions肠道微生物组与肥胖管理：连接饮食、手术及药物干预DOI: 10.1016/j.xcrm.2025.102573
Gait & posture IF: 02.400Ahead of Print.No.52Cognitive decline outweighs adiposity in influencing lower limb gait kinematics in older adults在影响老年人下肢步态运动学方面，认知功能下降重于肥胖水平DOI: 10.1016/j.gaitpost.2026.110104
J Psychosom Res IF: 03.300Ahead of Print.No.53The association between sleep trajectories throughout pregnancy and postpartum pain in individuals with overweight or obesity: A prospective cohort study超重或肥胖个体孕期睡眠轨迹与产后疼痛的关联：一项前瞻性队列研究DOI: 10.1016/j.jpsychores.2026.112535
Geriatric nursing IF: 02.400Ahead of Print.No.54Association of routine clinical indicators for metabolic and cardiovascular health with weight loss in non-obese older adults: A case-control study using annual health screening data in Japan常规代谢与心血管健康指标与非肥胖老年人体重减轻的关联：基于日本年度健康筛查数据的病例对照研究DOI: 10.1016/j.gerinurse.2026.103889
BMC endocrine disorders IF: 03.300Ahead of Print.No.55Incidence and risk factors for osteoporosis in people with type 2 diabetes mellitus in Thailand泰国2型糖尿病患者骨质疏松症的发病率和危险因素DOI: 10.1186/s12902-026-02165-6
?eská gynekologie IF: 00.500Volume 90, Issue 6No.56Status of a lipid accumulation product, triglycerides/ glucose index and visceral adiposity index on cardiometabolic risk factors in young polycystic ovary syndrome patients脂质蓄积产物、甘油三酯/葡萄糖指数与内脏肥胖指数在年轻多囊卵巢综合征患者心血管代谢风险因素中的状态评估DOI: 10.48095/cccg2025457
International dental journal IF: 03.700Ahead of Print.No.57Oral Health of Children With Severe or Complex Obesity and Association of Markers of Glucose Metabolism With Gingivitis重度或复杂性肥胖儿童的口腔健康及血糖代谢标志物与牙龈炎的相关性研究DOI: 10.1016/j.identj.2025.109383
Nature communications IF: 15.700Ahead of Print.No.58Epigenome-wide analysis identifies DNA methylation mediators of treatment-related cardiometabolic risk in survivors of childhood cancer表观基因组分析识别儿童癌症幸存者中治疗相关心血管代谢风险的DNA甲基化介导因子DOI: 10.1038/s41467-026-68689-6
Annals of hepatology IF: 04.400Ahead of Print.No.59Twofold increased risk of coronary artery disease after liver transplantation: A nationwide Swedish cohort of 2925 patients肝移植后冠心病风险增加两倍：瑞典全国性队列研究纳入2925例患者DOI: 10.1016/j.aohep.2025.102172
Value in health regional issues IF: 01.500Ahead of Print.No.60Retail Sales of Drugs for Diabetes, Dyslipidemia, and Hypertension in Chile Under 2 Health Policies2种健康政策下智利糖尿病、血脂异常和高血压药物的零售销售DOI: 10.1016/j.vhri.2025.101577
Neurochemical research IF: 03.800Volume 51, Issue 1No.61Metformin Ameliorates Cognitive Deficits and Neuroinflammation in a Mouse Model of Familial Hypercholesterolemia二甲双胍改善家族性高胆固醇血症小鼠模型的认知缺陷和神经炎症DOI: 10.1007/s11064-025-04658-7
European neuropsychopharmacology IF: 06.700Ahead of Print.No.62Antipsychotic plasma concentration as predictor of movement disorders and cardiometabolic side-effects: A comparison with prescription dose抗精神病药物血浆浓度作为运动障碍和心血管代谢副作用的预测因子：与处方剂量的比较DOI: 10.1016/j.euroneuro.2026.112769
Journal of clinical neuroscience IF: 01.800Ahead of Print.No.63Neuromuscular ultrasound and nerve conduction studies as complementary tools for screening of diabetic peripheral neuropathy神经肌肉超声与神经传导研究作为糖尿病周围神经病变筛查的互补工具DOI: 10.1016/j.jocn.2026.111876
CPT Pharmacometrics Syst Pharmacol IF: 03.000Volume 15, Issue 2No.64Preclinical Modeling and Simulation to Explore the Tissue/Plasma Exposure and Pharmacodynamic Effect of Vildagliptin in Diabetes Treatment临床前建模与模拟探索维格列汀在糖尿病治疗中的组织/血浆暴露及药效学效应DOI: 10.1002/psp4.70165
British journal of pharmacology IF: 07.700Ahead of Print.No.65Glucagon-like peptide-1 receptor agonists and muscle strength changes in older adults: Risks beyond muscle mass reductions胰高血糖素样肽-1受体激动剂与老年人肌力变化：超越肌肉量减少的风险DOI: 10.1111/bph.70355
Journal of neurosurgery. Spine IF: 03.100Ahead of Print.No.66The comparative impact of body mass index on outcomes following minimally invasive versus open surgery for grade 1 spondylolisthesis: 2-year follow-up from the Quality Outcomes Database体重指数对微创与开放手术治疗1级腰椎滑脱疗效的比较性影响：基于质量结局数据库的2年随访DOI: 10.3171/2025.9.SPINE25552
Lab on a chip IF: 05.400Ahead of Print.No.67Online affinity micro free-flow electrophoresis for the continuous monitoring of insulin via a competitive immunoassay基于竞争性免疫分析的在线亲和微自由流电泳技术用于胰岛素连续监测DOI: 10.1039/d5lc00745c
PloS one IF: 02.600Volume 21, Issue 1No.68Evaluation of rat pancreatic islets damage after siRNA microporationsiRNA微穿孔后大鼠胰腺胰岛的损伤评估DOI: 10.1371/journal.pone.0340066
Biomaterials IF: 12.900Ahead of Print.No.69Smart multifunctional ROS-responsive supramolecular hydrogel for simultaneously regulating oxidative stress, immune dysregulation, and bacterial infection in diabetic wound healing智能多功能ROS响应性超分子水凝胶同步调控糖尿病伤口愈合中的氧化应激、免疫失调和细菌感染DOI: 10.1016/j.biomaterials.2026.124006
Journal of neurosurgery IF: 03.600Ahead of Print.No.70Association of standard postoperative day 1 discharge following endonasal surgery for pituitary adenoma with lower complication rates and unplanned medical care垂体腺瘤经鼻手术后标准术后第1天出院与较低并发症率及未计划医疗照护相关DOI: 10.3171/2025.9.JNS25752
Journal of clinical oncology : IF: 41.900Ahead of Print.No.71Threshold Dose-Response Association Between Alcohol Consumption and Risk of Young-Onset Pancreatic Cancer: A Nationwide Korean Cohort Study of Young Adults Age 20-39 Years酒精消费与年轻发病胰腺癌风险的阈值剂量反应关联：一项针对韩国20-39岁年轻成人的全国性队列研究DOI: 10.1200/JCO-25-01169
Science advances IF: 12.500Volume 12, Issue 4No.72Neuronal GPR75 deficiency protects against diet-induced obesity in a humanized mouse model在人源化小鼠模型中，神经元GPR75缺陷可预防饮食诱导的肥胖DOI: 10.1126/sciadv.ady7993
Science advances IF: 12.500Volume 12, Issue 4No.73CD318 expression defines a novel subset of human CD8(+) regulatory T cellsCD318的表达定义了人类CD8(+)调节性T细胞的一个新亚群DOI: 10.1126/sciadv.adz4203
Science advances IF: 12.500Volume 12, Issue 4No.74TDRD3, a Tudor domain-containing protein, regulates Klf2-dependent T(reg) differentiation and function to modulate immune tolerance含有Tudor结构域的蛋白TDRD3通过调控Klf2依赖性Treg分化与功能调节免疫耐受DOI: 10.1126/sciadv.aea3960
PloS one IF: 02.600Volume 21, Issue 1No.75The role of obesity and Type 2 diabetes in lung health: A systematic review (2024)肥胖与2型糖尿病在肺健康中的作用：一项系统综述DOI: 10.1371/journal.pone.0340692
PloS one IF: 02.600Volume 21, Issue 1No.76Cardiovascular risk among middle-aged Japanese adults with atopic dermatitis: A nested case-control study日本中年特应性皮炎患者的心血管风险：一项巢式病例对照研究DOI: 10.1371/journal.pone.0341337
PloS one IF: 02.600Volume 21, Issue 1No.77Stress hyperglycemia ratio predicts adverse outcomes in emergency department patients with upper gastrointestinal bleeding应激性高血糖比值预测急诊上消化道出血患者不良结局DOI: 10.1371/journal.pone.0340450
PloS one IF: 02.600Volume 21, Issue 1No.78Pharmacological evaluation of mangrove plant Rhizophora mucronata (Lam.) grown in the coastal area of Sundarbans对生长在孙德尔本斯沿海地区的红树植物红茄苳（Rhizophora mucronata (Lam.)）的药理评价DOI: 10.1371/journal.pone.0340646
PloS one IF: 02.600Volume 21, Issue 1No.79Impact of cardiometabolic risk factors on hepatocellular carcinoma incidence in patients with chronic hepatitis B: A retrospective cohort study心脏代谢风险因素对慢性乙型肝炎患者肝细胞癌发病的影响：一项回顾性队列研究DOI: 10.1371/journal.pone.0341366
PloS one IF: 02.600Volume 21, Issue 1No.80Developing count regression techniques for predicting the number of new type 2 diabetes cases in Saudi Arabia开发计数回归技术预测沙特阿拉伯2型糖尿病新发病例数DOI: 10.1371/journal.pone.0341436
JMIR research protocols IF: 01.500Volume 15, Issue No.81Developing a Culturally Adapted Digital Health Application for Older Hispanic Adults With Type 2 Diabetes: Protocol for a Qualitative and Pilot Study为患有2型糖尿病的老年西班牙裔成年人开发文化适应性数字健康应用程序：一项定性和试点研究方案DOI: 10.2196/76294
Med Lett Drugs Ther IF: 01.400Volume 67, Issue 1743No.82Comparison chart: Some available insulins for type 2 diabetes对比图表：2型糖尿病部分可用胰岛素DOI: 10.58347/tml.2025.1743d
Med Lett Drugs Ther IF: 01.400Volume 67, Issue 1743No.83Insulins for type 2 diabetes2型糖尿病胰岛素疗法概览DOI: 10.58347/tml.2025.1743c
Med Lett Drugs Ther IF: 01.400Volume 67, Issue 1743No.84A cardiovascular indication for oral semaglutide (Rybelsus)口服司美格鲁肽(Rybelsus)的心血管适应症DOI: 10.58347/tml.2025.1743b
PloS one IF: 02.600Volume 21, Issue 1No.85HbA1c underperforms in identifying abnormal glucose tolerance in the presence of G6PD deficiency: Insight from the Africans in America study在G6PD缺乏症背景下，HbA1c识别糖耐量异常的效能降低：来自“美国非洲裔人群”研究的见解DOI: 10.1371/journal.pone.0334634
Med Lett Drugs Ther IF: 01.400Volume 68, Issue 1747No.86Risks of tramadol and gabapentin use for pain曲马多与加巴喷丁用于疼痛的风险DOI: 10.58347/tml.2026.1747d
Appl Biochem Biotechnol IF: 03.300Ahead of Print.No.87Modulatory Role of Moringa Oleifera-Loaded Silver Nanoparticles on UCP1 and PPARGC1A Genes Expression in an Obesity Rat Model辣木负载银纳米颗粒在肥胖大鼠模型中对UCP1和PPARGC1A基因表达的调节作用DOI: 10.1007/s12010-025-05511-x
Pediatric nephrology IF: 02.600Ahead of Print.No.88Beyond genetics: how environmental stressors drive pediatric hypertension risk超越遗传学：环境压力因素如何驱动儿童高血压风险DOI: 10.1007/s00467-025-07145-x
J Nutr Educ Behav IF: 02.300Ahead of Print.No.89Stakeholder Perspectives on Remote Delivery of a Group-Based Child Obesity Prevention Program for Latino Families With Low Income利益相关者对拉丁裔低收入家庭基于群体的儿童肥胖预防项目远程实施的看法DOI: 10.1016/j.jneb.2025.12.004
Immunological reviews IF: 08.300Volume 338, Issue 1No.90Sex Differences in the Impact of Obesity on Immunity肥胖对免疫影响中的性别差异DOI: 10.1111/imr.70101
Cancer science IF: 04.300Ahead of Print.No.91Effect Modification by Cofactors in the Impact of Body Mass Index Change on the Risk of Lung Cancer体重指数变化对肺癌风险的影响：多种因素的效应修饰作用DOI: 10.1111/cas.70332
Die Chirurgie IF: 00.600Ahead of Print.No.92[Oral intake of 25 mg semaglutide in adults with overweight or obesity]超重或肥胖成人中口服25毫克司美格鲁肽DOI: 10.1007/s00104-026-02452-x
Clin Transl Oncol IF: 02.500Ahead of Print.No.93IRS2 as a driver and therapeutic target in brain metastases from colorectal cancer: a systematic review of mechanistic and translational evidenceIRS2作为结直肠癌脑转移的驱动因子和治疗靶点：机制与转化证据的系统综述DOI: 10.1007/s12094-025-04212-5
Arch Gynecol Obstet IF: 02.500Volume 313, Issue 1No.94Impact of hormones on lipedema development: a systematic literature review激素对脂肪水肿发展的影响：一项系统性文献综述DOI: 10.1007/s00404-026-08318-1
Macromolecular bioscience IF: 04.100Volume 26, Issue 1No.95Identification of Novel Growth Factor Conjugated Nanofibers for Stimulation of Neuronal Growth鉴定用于刺激神经元生长的生长因子共轭纳米纤维DOI: 10.1002/mabi.202500585
J Int Med Res IF: 01.500Volume 54, Issue 1No.96Relationship of body composition with cortisol and dehydroepiandrosterone sulfate levels in Korean men and women韩国成年男女身体成分与皮质醇及脱氢表雄酮硫酸盐水平的关系DOI: 10.1177/03000605251413389
Med Lett Drugs Ther IF: 01.400Volume 68, Issue 1747No.97Oral semaglutide (Wegovy) for weight loss口服司美格鲁肽（Wegovy）用于减重DOI: 10.58347/tml.2026.1747a
La Revue du praticienVolume 75, Issue 9No.98[Why and how should the renal risk of patients with type 2 diabetes be assessed ?]为何及如何评估2型糖尿病患者的肾脏风险https://pubmed.ncbi.nlm.nih.gov/41575136
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.99SGLT2 inhibitors and mortality in older adults with diabetic kidney disease: A target trial emulation studySGLT2抑制剂与老年糖尿病肾病患者死亡率：一项靶向试验仿真研究DOI: 10.1111/dom.70502
JAMA IF: 55.000Ahead of Print.No.100Higher Food Preservative Intake Linked With Type 2 Diabetes食物防腐剂摄入量增加与2型糖尿病相关DOI: 10.1001/jama.2025.23033
JAMA Network Open IF: 09.700Volume 9, Issue 1No.101Voice Assistant for Older Adults With Type 2 Diabetes面向2型糖尿病老年患者的语音助手DOI: 10.1001/jamanetworkopen.2025.53483
Eur J Clin Microbiol Infect Dis IF: 03.000Ahead of Print.No.102Epidemiological profile and clinical outcomes of patients with mucormycosis: the multicenter retromucor study from Türkiye (2004-2024)毛霉菌病患者的流行病学特征与临床结局：土耳其多中心retromucor研究（2004-2024）DOI: 10.1007/s10096-025-05397-x
Current obesity reports IF: 11.000Volume 15, Issue 1No.103Gut Peptide Alterations in Type 2 Diabetes and Obesity: A Narrative Review肠道肽在2型糖尿病与肥胖中的改变：叙事综述DOI: 10.1007/s13679-026-00687-7
J Physiol Biochem IF: 04.300Volume 82, Issue 1No.104Procyanidin B2 and an autochthonous apple pulp extract modulate oxidative stress and PPARγ expression on an in vitro model of lipid steatosis in HepG2 cells原花青素B2与一种本土苹果果肉提取物在HepG2细胞脂质变性体外模型中调节氧化应激与PPARγ表达DOI: 10.1007/s13105-026-01151-9
Diabetes Technol Ther IF: 06.300Ahead of Print.No.105Safety of Inhaled Insulin in Adults with Diabetes吸入胰岛素在成人糖尿病患者中的安全性DOI: 10.1177/15209156251390830
Kidney360 IF: 03.000Ahead of Print.No.106Clinical Characteristics and Disease Progression Among Non-Diabetic APOL1-Mediated Kidney Disease Patients and Patients with Other CKD非糖尿病APOL1介导的肾脏病患者与其他慢性肾脏病患者的临床特征及疾病进展比较DOI: 10.34067/KID.0000001097
JACC: Clinical Electrophysiology IF: 07.700Ahead of Print.No.107Transcatheter Tricuspid Valve Replacement in Patients With Cardiac Implantable Electronic Device Leads: The TRIPLACE Registry在伴心脏植入式电子装置导线的患者中行经导管三尖瓣置换术：TRIPLACE注册研究DOI: 10.1016/j.jacep.2025.12.027
Diabetes care IF: 16.600Ahead of Print.No.108The Look AHEAD Research Program: A 25-Year Retrospective From the Perspective of GeroscienceLook AHEAD研究项目：基于老年科学视角的25年回顾DOI: 10.2337/dci25-0126
Diabetes care IF: 16.600Ahead of Print.No.109Interlaboratory Evaluation of Multiplex Autoantibody Assay Performance in the Islet Autoantibody Standardization Program 2024 Workshop胰岛自身抗体标准化程序2024研讨会：多重自身抗体检测性能的室间评估DOI: 10.2337/dc25-1326
Reproduction IF: 03.700Ahead of Print.No.110Curating Fertility-Proteomic Remodelling of Sperm During Epididymal Transit塑造生育力：精子在附睾转运中的蛋白质组重塑DOI: 10.1093/reprod/xaag012
Organic letters IF: 05.000Ahead of Print.No.111Total Synthesis of Okeaniamide AOkeaniamide A的全合成DOI: 10.1021/acs.orglett.5c05432
Annals of African medicine IF: 00.600Ahead of Print.No.112Management of Chronic Pancreatitis with Pancreatic Duct Calculi伴有胰管结石的慢性胰腺炎的治疗DOI: 10.4103/aam.aam_654_25
La Revue du praticienVolume 75, Issue 9No.113[What are the key takeaways from the HAS recommendations regarding special populations (elderly populations and pregnancy or planning to become pregnant) ?]关于特殊人群（老年人群、孕产妇或备孕者），法国国家卫生管理局（HAS）建议的要点是什么？https://pubmed.ncbi.nlm.nih.gov/41575137
La Revue du praticienVolume 75, Issue 9No.114[Lifestyle modifications in type 2 diabetes: yes, but how ?]2型糖尿病的生活方式干预：方向明确，如何落实？https://pubmed.ncbi.nlm.nih.gov/41575134
La Revue du praticienVolume 75, Issue 9No.115[From glycemic control to comprehensive management of patients living with type 2 diabetes: a paradigm shift ?]从血糖控制到2型糖尿病患者的综合管理：一场范式转变https://pubmed.ncbi.nlm.nih.gov/41575132
MS. Me?decine sciences IF: 00.400Volume 42, Issue 1No.116[Intestinal microbiota biodiversity and the modern diet: consequences for human health]肠道微生物群多样性与现代饮食：对人类健康的影响DOI: 10.1051/medsci/2025253
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.117Efficacy and safety of once-weekly insulins in type 2 diabetes: A systematic review and meta-analysis一周一次胰岛素在2型糖尿病中的有效性与安全性：一项系统评价与Meta分析DOI: 10.1111/dom.70497
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.118Lorcaserin induces abdominal fat loss with associated improvements of the circulating metabolome/lipidome and no changes in the myostatin-activin-follistatin-IGF-1 axes: A 6-month long randomized placebo-controlled clinical trial氯卡色林通过改善循环代谢组/脂质组谱诱导腹部脂肪减少，且不改变肌肉生长抑制素-激活素-卵泡抑素-IGF-1轴：一项为期6个月的随机安慰剂对照临床试验DOI: 10.1111/dom.70496
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.119Methylglyoxal-derived hydroimidazolone (MG-H1) is a novel marker of insulin resistance in Japanese individuals, disturbing insulin signalling via mTORC2 in cultured myocytes甲基乙二醛衍生的氢咪唑酮(MG-H1)是日本人群胰岛素抵抗的新标志物，通过mTORC2干扰培养肌细胞的胰岛素信号DOI: 10.1111/dom.70489
Health promotion practice IF: 01.200Ahead of Print.No.120Evaluation of a Prediabetes Media Campaign for Black and Hispanic Men to Increase Awareness of Diabetes Prevention and Address Health Inequity一项针对黑人和西班牙裔男性的糖尿病前期媒体运动评估：旨在提高糖尿病预防意识并解决健康不平等问题DOI: 10.1177/15248399251414653
Acta Cardiologica IF: 02.500Ahead of Print.No.121Incidence, risk factors and prognostic impact of cerebrovascular events after transcatheter aortic valve implantation经导管主动脉瓣植入术后脑血管事件的发生率、风险因素及预后影响DOI: 10.1080/00015385.2026.2617492
American journal of epidemiology IF: 04.800Ahead of Print.No.122Thyroid autoimmunity and the subsequent development of islet and celiac autoimmunity in the TEDDY study甲状腺自身免疫与后续胰岛及乳糜泻自身免疫的发展：TEDDY研究DOI: 10.1093/aje/kwag016
Annals of African medicine IF: 00.600Ahead of Print.No.123Stem Cell Therapy as a Regenerative Strategy in Hereditary Pancreatitis Postpancreatectomy干细胞疗法作为遗传性胰腺炎胰腺切除术后的再生策略DOI: 10.4103/aam.aam_509_25
J Diabetes Investig IF: 03.000Ahead of Print.No.124Erythrocyte deformability correlates with microvascular ischemia and disease severity in diabetic retinopathy红细胞变形能力与糖尿病视网膜病变的微血管缺血和疾病严重程度相关DOI: 10.1111/jdi.70247
J Diabetes Investig IF: 03.000Ahead of Print.No.125A pitfall in diagnosing type B insulin resistance syndrome: Suspected antibody interference in a patient with insulin allergy诊断B型胰岛素抵抗综合征的一个陷阱：胰岛素过敏患者中的疑似抗体干扰DOI: 10.1111/jdi.70235
J Diabetes Investig IF: 03.000Ahead of Print.No.126Increased C-reactive protein is associated with corneal nerve loss and painful neuropathic symptoms in Type 2 diabetes mellitusC反应蛋白升高与2型糖尿病患者角膜神经损失及疼痛性神经病变症状相关DOI: 10.1111/jdi.70246
Eur J Neurosci IF: 02.400Volume 63, Issue 2No.127Electrical Synapses Contribute to Sleep-Dependent Declarative Memory Retention电突触促进睡眠依赖性陈述性记忆保留DOI: 10.1111/ejn.70401
Pol Arch Intern Med IF: 04.700Ahead of Print.No.128Determining the association between preeclampsia and the thyroid hormone status in pregnant women with type 1 diabetes探究1型糖尿病孕妇先兆子痫与甲状腺激素状态的关联性DOI: 10.20452/pamw.17199
International wound journal IF: 02.500Volume 23, Issue 1No.129A Prospective Randomised Clinical Study Comparing Polygalacturonic and Caprylic Acid Ointment to Medical-Grade Honey in the Management of Chronic Wounds比较聚半乳糖醛酸-辛酸软膏与医用级蜂蜜治疗慢性伤口的前瞻性随机临床研究DOI: 10.1111/iwj.70815
JCI insight IF: 06.100Volume 11, Issue 2No.130Anti-CD3 mAb treatment reshapes infiltrating T and β cells in the islets in autoimmune diabetes抗CD3单抗治疗重塑自身免疫性糖尿病胰岛中的浸润性T细胞与β细胞DOI: 10.1172/jci.insight.192755
La Revue du praticienVolume 75, Issue 8No.131[Management of neuropathic pain: Don't lose hope!]神经病理性疼痛的管理：不要失去希望https://pubmed.ncbi.nlm.nih.gov/41575077
La Revue du praticienVolume 75, Issue 9No.132[Pharmacological management of non-insulin-treated type 2 diabetes: practical implementation of HAS guidelines]非胰岛素治疗的2型糖尿病的药物治疗：法国国家卫生管理局指南的实践实施https://pubmed.ncbi.nlm.nih.gov/41575133
Science progress IF: 02.900Volume 109, Issue 1No.133Retraction: Potassium bromate-induced nephrotoxicity and potential curative role of metformin loaded on gold nanoparticles撤稿：溴酸钾诱导的肾毒性及负载于金纳米颗粒的甲福明潜在治疗作用DOI: 10.1177/00368504261417035
Annals of African medicine IF: 00.600Ahead of Print.No.134Evaluating Antenatal Depression in Women with Gestational Diabetes Mellitus: A Hospital-based Observational Study妊娠期糖尿病女性产前抑郁评估：一项医院为基础的观察性研究DOI: 10.4103/aam.aam_700_25
La Revue du praticienVolume 75, Issue 9No.135[Why and how should the cardiovascular risk of patients with type 2 diabetes be assessed ?]为何以及如何评估2型糖尿病患者的心血管风险？https://pubmed.ncbi.nlm.nih.gov/41575135
Cancer Epidemiol Biomarkers Prev IF: 03.400Ahead of Print.No.136The Potential Impact of Histamine-2 Receptor Antagonists on Gynecologic Cancer Risk: A Population-Based Study of 23 Million IndividualsH2受体拮抗剂对妇科癌症风险的潜在影响：一项基于2300万人的群体研究DOI: 10.1158/1055-9965.EPI-25-1306
JACC: AdvancesVolume 5, Issue 2No.137FDA Cardiovascular Indication Expansion and Dispensing of Semaglutide/Tirzepatide in CVD Patients With Overweight/ObesityFDA心血管适应症扩展及司美格鲁肽/替尔泊肽在心血管疾病合并超重/肥胖患者中的处方情况DOI: 10.1016/j.jacadv.2025.102575
JACC: AdvancesVolume 5, Issue 2No.138Wireless Movement Activity and Cardiometabolic Disease Risk in Historical Redlined Areas历史红线划定区域内的无线移动活动与心血管代谢疾病风险DOI: 10.1016/j.jacadv.2025.102528
EBioMedicine IF: 10.800Volume 124, Issue No.139Endocrine and metabolic determinants of cardiometabolic risk in mild autonomous cortisol secretion轻度自主皮质醇分泌患者心脏代谢风险的内分泌和代谢决定因素DOI: 10.1016/j.ebiom.2026.106126
CNS Neurol Disord Drug Targets IF: 03.000Ahead of Print.No.140Investigation of the Antiepileptic and Anti-inflammatory Effects of Empagliflozin on Penicillin-induced Epileptiform Activity in Rats恩格列净对青霉素诱发大鼠癫痫样活动的抗癫痫及抗炎作用研究DOI: 10.2174/0118715273423680251125073602
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.141Diabetes and tumor risk: a 23-year Danish national cohort study糖尿病与肿瘤风险：一项为期23年的丹麦全国队列研究DOI: 10.3389/fendo.2025.1725065
Frontiers in nutrition IF: 05.100Volume 12, Issue No.142Editorial: The role of vitamin D in metabolic and cardiovascular health, volume II社论：维生素D在代谢和心血管健康中的作用（第二卷）DOI: 10.3389/fnut.2025.1759053
Diabetes Technol Ther IF: 06.300Ahead of Print.No.143Response to Comment on: "Nocturnal Hypoglycemia: Characterization with Continuous Glucose Monitoring in a Real-World Setting"对“夜间低血糖：真实世界环境中连续葡萄糖监测特征分析”评论的回应DOI: 10.1177/15209156251412814
Diabetes Technol Ther IF: 06.300Ahead of Print.No.144Hybrid Closed-Loop Disconnection Reduces the Risk of Hypoglycemia in Active Children and Adolescents with Type 1 Diabetes: A Randomized Controlled Pilot Study混合闭环系统断开可降低活跃1型糖尿病儿童及青少年的低血糖风险：一项随机对照试验DOI: 10.1177/15209156251390825
Eur J Endocrinol IF: 05.200Ahead of Print.No.145Long-Term Cardiac Effects of Adrenalectomy Versus Surveillance in Mild Cortisol Excess: 5-Year Results from the prospective ITACA Study轻度皮质醇过量中肾上腺切除术与监测的长期心脏效应：前瞻性ITACA研究的5年结果DOI: 10.1093/ejendo/lvag018
Current medicinal chemistry IF: 03.500Ahead of Print.No.146Differences of Plasma Metabolites in Sarcopenia Among Individuals with Type 2 Diabetes: A Cross-Sectional Study2型糖尿病患者肌少症的血浆代谢物差异：一项横断面研究DOI: 10.2174/0109298673417152251129140654
Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 1No.147Socioeconomic Inequalities and Type 2 Diabetes Comorbidities: A Systematic Review and Meta-Analysis on Observational Studies社会经济不平等与2型糖尿病合并症：一项基于观察性研究的系统评价与Meta分析DOI: 10.1002/edm2.70160
Sociology of health & illness IF: 02.700Volume 48, Issue 2No.148Transformations in Diabetes Care: Lessons From Commons-Based, Peer-Produced Citizen Science糖尿病护理的变革：来自基于公地、同伴生产的公民科学的启示DOI: 10.1111/1467-9566.70140
Med Sci Sports Exerc IF: 03.900Ahead of Print.No.149Stem Cell Transplant Patients' Activity Decline, Outpatient Resumption and Intervention Effectiveness Identified by Wearable Activity Monitoring通过可穿戴活动监测识别干细胞移植患者的活动下降、门诊恢复及干预效果DOI: 10.1249/MSS.0000000000003941
Transplantation IF: 05.000Ahead of Print.No.150Improving Bone Health in Type 1 Diabetes and Chronic Kidney Disease: The Overlooked Benefit of Simultaneous Pancreas-Kidney Transplantation改善1型糖尿病和慢性肾脏病中的骨骼健康：同步胰肾移植的被忽视的益处DOI: 10.1097/TP.0000000000005631
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.151Editorial: Applications of optical coherence tomography angiography (OCTA) in ocular complications of diabetes mellitus光学相干断层扫描血管成像（OCTA）在糖尿病眼部并发症中的应用DOI: 10.3389/fendo.2025.1743554
Drug delivery IF: 08.100Volume 33, Issue 1No.152Advancements and challenges in ophthalmic microneedles to treat eye diseases眼科微针在治疗眼部疾病中的进展与挑战DOI: 10.1080/10717544.2026.2617688
Molecular pharmaceutics IF: 04.500Ahead of Print.No.153Molecular Mechanisms of Liraglutide Aggregation Induced by Dual Air-Water and Silicone-Oil-Water Interfacial Stress空气-水与硅油-水双重界面应力诱导利拉鲁肽聚集的分子机制DOI: 10.1021/acs.molpharmaceut.5c01837
Bioeng Transl Med IF: 05.700Volume 11, Issue 1No.154Injectable hyaluronic acid-metformin conjugate gel for sustained intra-articular delivery and prevention of post-traumatic osteoarthritis可注射透明质酸-二甲双胍共轭凝胶用于关节内持续给药及创伤后骨关节炎的预防DOI: 10.1002/btm2.70100
Frontiers in psychiatry IF: 03.200Volume 16, Issue No.155Case Report: Persistent delusional memories after postoperative delirium in a woman with complex cardiac surgical history病例报告：一例具有复杂心脏手术史女性术后谵妄后的持久妄想性记忆DOI: 10.3389/fpsyt.2025.1743329
bioRxivVolume 2026, Issue No.156Lifespan-extending downregulation of insulin signalling reduces germline mutation load延长寿命的胰岛素信号下调可降低生殖细胞突变负荷DOI: 10.64898/2025.12.05.692572
bioRxivVolume 2026, Issue No.157A Fourfold Male-Specific Lifespan Extension via Canonical Insulin/IGF-1 Signaling经由经典胰岛素/IGF-1信号通路实现的雄性特异性四倍寿命延长DOI: 10.64898/2025.12.02.691904
bioRxivVolume 2026, Issue No.158AKT signaling in hepatocytes rapidly increases glucose phosphorylation and contribution to glycogen without affecting metabolite pool sizes or glycogen breakdown肝细胞中AKT信号快速增加葡萄糖磷酸化及向糖原的贡献，而不影响代谢物池大小或糖原分解DOI: 10.64898/2025.12.01.691331
bioRxivVolume 2026, Issue No.159Insular cortex predictions regulate glucose homeostasis岛叶皮层的预测调控葡萄糖稳态DOI: 10.64898/2025.12.09.693191
Curēus IF: 01.300Volume 17, Issue 12No.160Atypical Presentation and Unexpected Resolution: The Role of Serial Cerebrospinal Fluid Analysis in Differentiating Bacterial and Viral Meningitis After Pituitary Surgery垂体术后脑膜炎的不典型表现与转归：系列脑脊液分析在鉴别细菌性与病毒性感染中的关键作用DOI: 10.7759/cureus.99802
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.161Stc2a inhibits IGF-stimulated somatic growth in favor of organismal survival under hypoxic stressStc2a在低氧应激下抑制IGF介导的体细胞生长以利于机体存活DOI: 10.3389/fendo.2025.1729649
Pediatric diabetes IF: 05.600Volume 2026, Issue No.162Maternal Autoimmune Disease and Childhood-Onset Type 1 Diabetes: A Nationwide Population-Based Nested Case-Control Study母体自身免疫病与儿童期发病的1型糖尿病：一项全国性人群巢式病例对照研究DOI: 10.1155/pedi/3418021
Mol Nutr Food Res IF: 04.200Volume 70, Issue 2No.163A Comparative Study on the Effect of Omega-3 Fatty Acids on Lactationω-3脂肪酸对哺乳期影响的比较研究DOI: 10.1002/mnfr.70393
Epigenomics IF: 02.600Ahead of Print.No.164Paternal preconception exercise and sperm epigenetic mechanisms: a systematic review on offspring health父亲孕前运动与精子表观遗传机制：关于后代健康的系统综述DOI: 10.1080/17501911.2026.2620390
Current pharmaceutical design IF: 02.800Ahead of Print.No.165Gut Microbiota in the Hepato-Cardiorenal Axis: Microbial Metabolites, Inflammation, and Emerging Therapeutic Targets肝心肾轴中的肠道微生物群：微生物代谢产物、炎症与新兴治疗靶点DOI: 10.2174/0113816128413464251209115653
Cell transplantation IF: 03.200Volume 35, Issue No.166Editorial: Cellular replacement therapy for diabetes社论：糖尿病细胞替代疗法DOI: 10.1177/09636897251392313
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.167CGM-derived efficacy and overall safety of once-weekly insulin efsitora alfa (efsitora) relative to day of administration in adults with type 2 diabetes连续血糖监测评估的每周一次胰岛素efsitora alfa（efsitora）在2型糖尿病成人患者中的有效性和总体安全性：与给药日相关DOI: 10.1111/dom.70419
Molecular pharmaceutics IF: 04.500Ahead of Print.No.168Soluble Antigen Array Displaying Proinsulin(F25D) Selectively Targets Anti-insulin B Cells without Hormonal Effects展示前胰岛素(F25D)突变体的可溶性抗原阵列选择性靶向抗胰岛素B细胞且无激素效应DOI: 10.1021/acs.molpharmaceut.5c01428
Med Sci Sports Exerc IF: 03.900Ahead of Print.No.169Metabolic Effects of Isoenergetic High Intensity Interval Training and Moderate Intensity Continuous Training in Adults with Type I Diabetes等能量高强度间歇训练与中等强度持续训练对1型糖尿病成人的代谢影响DOI: 10.1249/MSS.0000000000003939
FCVM IF: 02.900Volume 12, Issue No.170Effects of fasting on endothelial function in type 2 diabetes mellitus patients: cohort study斋月禁食对2型糖尿病患者内皮功能的影响：一项队列研究DOI: 10.3389/fcvm.2025.1646786
Curēus IF: 01.300Volume 17, Issue 12No.171Unilateral Ptosis and Bulbar Symptoms as the Initial Presentation of Late-Onset Acetylcholine Receptor Antibody-Positive Myasthenia Gravis Mimicking Acute Ischemic Stroke in an 82-Year-Old Man单侧眼睑下垂与球部症状：一例82岁男性晚发性乙酰胆碱受体抗体阳性重症肌无力模仿急性缺血性卒中的初始表现DOI: 10.7759/cureus.99832
Current diabetes reviews IF: 01.900Ahead of Print.No.172The Beneficial Effects of Combination Therapy With SGLT-2 Inhibitors and GLP-1 Receptor Agonists in Type 2 Diabetes MellitusSGLT-2抑制剂与GLP-1受体激动剂联合治疗对2型糖尿病的有益效应DOI: 10.2174/0115733998419380251126073540
Endocr Metab Immune Disord Drug Targets IF: 02.000Ahead of Print.No.173Insight into Molecular Mechanisms and Pathways Related to the Association of Periodontal Disease and Type 2 Diabetes Mellitus牙周病与2型糖尿病关联的分子机制与通路研究进展DOI: 10.2174/0118715303415067251124044844
Scand J Rheumatol IF: 02.100Ahead of Print.No.174Organ-specific autoimmunity in primary Sjögren's disease原发性干燥综合征中的器官特异性自身免疫DOI: 10.1080/03009742.2025.2598989
Current pharmaceutical design IF: 02.800Ahead of Print.No.175Histone Acetylation Retards the Adipogenic Differentiation of Human Umbilical Cord - Mesenchymal Stem Cells: A Clue for Anti-obesity Approach?组蛋白乙酰化延缓人脐带间充质干细胞的成脂分化：抗肥胖方法的一条线索？DOI: 10.2174/0113816128396945251127151448
Mol Nutr Food Res IF: 04.200Volume 70, Issue 2No.176Wheat Flour Intake Promotes Weight Gain and Metabolic Changes in Mice小麦粉摄入促进小鼠体重增加和代谢变化DOI: 10.1002/mnfr.70394
Acta Biochimica Polonica IF: 01.700Volume 72, Issue No.177Prevalence of vitamin D deficiency and related factors among adults in Tokat province, Türkiye: a community-based cross-sectional study土耳其托卡特省成人维生素D缺乏患病率及相关因素：一项基于社区的横断面研究DOI: 10.3389/abp.2025.15459
Health Psychol Behav Med IF: 02.200Volume 14, Issue 1No.178Developing a theory and evidence-based intervention for black African women using the COM-B model and behaviour change wheel: BALANCED programme运用COM-B模型与行为改变轮，为非裔黑人女性构建理论与循证干预：BALANCED项目DOI: 10.1080/21642850.2026.2616929
J Exp Orthop IF: 02.700Volume 13, Issue 1No.179Outcomes of total hip arthroplasty in obese patients with and without preoperative weight loss: A systematic review and meta-analysis肥胖患者全髋关节置换术结局：术前减重与未减重的系统评价与荟萃分析DOI: 10.1002/jeo2.70651
Frontiers in physiology IF: 03.400Volume 16, Issue No.180The role of impaired adipogenesis in insulin resistance among non-obese individuals脂肪生成障碍在非肥胖个体胰岛素抵抗中的作用DOI: 10.3389/fphys.2025.1739215
Journal of wrist surgery IF: 00.600Volume 15, Issue 1No.181Comparative Analysis of Comorbidities and Outcomes in Endoscopic versus Open Treatment of Carpal Tunnel Release in Patients with Rheumatoid Arthritis类风湿关节炎患者内镜与开放式腕管松解术比较分析DOI: 10.1055/s-0044-1791266
Front Clin Diabetes Healthc IF: 02.200Volume 6, Issue No.182Reduction of insulin resistance in 14-15-year-old students after the COVID-19 pandemic: a prospective study from Tsunan, JapanCOVID-19大流行后日本津南町14-15岁学生胰岛素抵抗的减少：一项前瞻性研究DOI: 10.3389/fcdhc.2025.1687294
Annals of neurosciences IF: 02.400Ahead of Print.No.183Association of Heart Rate Variability and NeuroCognitive Performance Among Metabolically Healthy Obese Adults: Cardio-psychological Based Approach心率变异性与神经认知功能的关联：针对代谢健康肥胖成年人的心脏心理学方法DOI: 10.1177/09727531251409528
J Educ Health Promot IF: 01.300Volume 14, Issue No.184Exploring the interplay between stress level, sleep quality, and body composition among university students: A cross-sectional study探究大学生压力水平、睡眠质量与身体成分之间的相互作用：一项横断面研究DOI: 10.4103/jehp.jehp_1947_24
J Educ Health Promot IF: 01.300Volume 14, Issue No.185Impact of sleep quality and physical activity on hypertension in adults: Findings from rural eastern India睡眠质量与体力活动对成人高血压的影响：来自印度东部农村地区的发现DOI: 10.4103/jehp.jehp_2133_24
bioRxivVolume 2026, Issue No.186Ovarian Hormones and Obesity Drive Th17-mediated Airway Inflammation through Estrogen Receptor Signaling卵巢激素与肥胖通过雌激素受体信号驱动Th17介导的气道炎症DOI: 10.64898/2025.12.02.691857
bioRxivVolume 2026, Issue No.187High-Fat Diet Induces Epigenetic and Metabolic Changes in Kisspeptin Neurons in Association with Obesity and Male Secondary Hypogonadism高脂饮食诱导Kisspeptin神经元的表观遗传和代谢改变，与肥胖及男性继发性性腺功能减退相关DOI: 10.64898/2025.11.30.691258
Sisli Etfal Hastan T?p Bul IF: 01.000Volume 59, Issue 3No.188Evaluation of Our Paediatric Patients Hospitalised with Covid-19 Diagnosis: Single Centre Experience我们因COVID-19诊断住院的儿科患者的评估：单中心经验DOI: 10.14744/SEMB.2025.73483
Curēus IF: 01.300Volume 17, Issue 12No.189Neurological Outcomes Following Surgical Resection of Intradural Extramedullary Spinal Tumors: A Retrospective Analysis Using the American Spinal Injury Association (ASIA) Impairment Scale使用美国脊髓损伤协会(ASIA)损伤量表评估硬膜内髓外脊髓肿瘤手术切除后的神经功能预后：一项回顾性分析DOI: 10.7759/cureus.99857
Curēus IF: 01.300Volume 17, Issue 12No.190Beyond Snoring: Unexpected Presentation of Obstructive Sleep Apnea不只是打鼾：阻塞性睡眠呼吸暂停的非典型表现DOI: 10.7759/cureus.99866
Curēus IF: 01.300Volume 17, Issue 12No.191Healthy Lifestyle Interventions for Non-communicable Disease Prevention in Saudi Arabia: A Scoping Review沙特阿拉伯非传染性疾病预防的生活方式干预：一项范围综述DOI: 10.7759/cureus.99800
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.192Effects of stress on bone health in children压力对儿童骨骼健康的影响DOI: 10.3389/fendo.2025.1715779
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.193Deciphering obesity: a conceptual overview and synthesis解码肥胖：概念性概览与综合DOI: 10.3389/fendo.2025.1738147
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.194Abdominal versus femoral subcutaneous fat gene expression in non-obese insulin resistant individuals非肥胖胰岛素抵抗个体腹部与大腿皮下脂肪基因表达对比DOI: 10.3389/fendo.2025.1684761
Obesity science & practice IF: 01.900Volume 12, Issue 1No.195Recent Insights Into Circulating Adipokines in Obesity: Systematic Review and Meta-Analysis肥胖中循环脂肪因子最新见解：系统综述与荟萃分析DOI: 10.1002/osp4.70113
Frontiers in nutrition IF: 05.100Volume 12, Issue No.196The excess body fat is a potential mediator between consumption of ultra-processed foods and cardiometabolic risk in normal-weight Brazilian children超重是超加工食品消费与巴西正常体重儿童心脏代谢风险之间潜在的中介因素DOI: 10.3389/fnut.2025.1726016
Public health nutrition IF: 03.000Ahead of Print.No.197Nutrition Inequities in the Deaf Community: A Call for Inclusive Public Health Action听障社区的营养不平等：呼吁包容性公共卫生行动DOI: 10.1017/S1368980026101864
Endocr Metab Immune Disord Drug Targets IF: 02.000Ahead of Print.No.198Effects of Swimming Exercise and L-Carnitine Administration on Insulin Resistance in Juvenile Obese Rats with Type 2 Diabetes游泳运动与L-肉碱干预对青少年肥胖2型糖尿病大鼠胰岛素抵抗的影响DOI: 10.2174/0118715303413143251031170236
J Dev Orig Health Dis IF: 01.500Volume 17, Issue No.199Mild fructose diet during periadolescent development increases emotionality, but not metabolic consequences of early life adversity in rats围青春期轻度果糖饮食增加大鼠的情绪性，但不加剧早期生活逆境的代谢后果DOI: 10.1017/S2040174425100433
Statistics in medicine IF: 01.800Volume 45, Issue 1-2No.200A Functional Approach to Testing Overall Effect of Interaction Between DNA Methylation and SNPs一种测试DNA甲基化与SNPs相互作用总体效应的功能方法DOI: 10.1002/sim.70364
Lupus IF: 01.900Ahead of Print.No.201Serum BAFF levels in pregnant patients with systemic lupus erythematosus系统性红斑狼疮孕妇患者的血清BAFF水平DOI: 10.1177/09612033261419984
Obesity reviews IF: 07.400Ahead of Print.No.202Effect of Citrus bergamia Supplementation on Body Composition in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials香柠檬补充剂对人体体成分影响的系统评价与荟萃分析：随机对照试验研究DOI: 10.1111/obr.70094
Childhood obesity IF: 01.400Ahead of Print.No.203Pragmatic Pilot Study of the Healthy Living Program: An Obesity Prevention and Treatment Program for Low-Income Hispanic Families Delivered Through Clinic-Community Partnership《健康生活计划》实用试点研究：一项通过诊所-社区合作为低收入西班牙裔家庭提供的肥胖预防与治疗计划DOI: 10.1177/21532176251410314
Asian J Endosc Surg IF: 00.900Volume 19, Issue 1No.204Short-Term Operative Outcomes of Loop Reconstruction for Duodenojejunal Bypass With Sleeve Gastrectomy: A Retrospective Study From a Single Japanese Academic Hospital十二指肠空肠旁路联合袖状胃切除术的环状重建的短期手术效果：一项来自日本单一学术医院的回顾性研究DOI: 10.1111/ases.70245
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.205Cardiometabolic implications of triglyceride-glucose index, remnant cholesterol, and vitamin D in normoglycemic Arab adolescents: a cross-sectional study甘油三酯-葡萄糖指数、残余胆固醇与维生素D对血糖正常阿拉伯青少年代谢心血管的意义：一项横断面研究DOI: 10.3389/fendo.2025.1674706
Curr Pharm Biotechnol IF: 02.600Ahead of Print.No.206Protective Role of Glibenclamide and Magnesium Sulfate in Fructoseinduced Type 2 Diabetes Mellitus格列本脲与硫酸镁在果糖诱导的2型糖尿病中的保护作用DOI: 10.2174/0113892010396082251107094426
Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 1No.207Association Between the Triglycerides-to-High-Density Lipoprotein-Cholesterol (TG/HDL-C) Ratio and Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Observational Studies甘油三酯与高密度脂蛋白胆固醇比值（TG/HDL-C）与慢性肾脏病关联性的系统综述与荟萃分析DOI: 10.1002/edm2.70161
Curēus IF: 01.300Volume 17, Issue 12No.208Unanticipated Residual Gastric Contents in an Appropriately Fasted Pediatric Patient on Glucagon-Like Peptide-1 Receptor Agonist Therapy: A Case Report and Review of Perioperative ConsiderationsGLP-1受体激动剂治疗儿科患者中未预期的胃内容物残留：病例报告及围术期考量DOI: 10.7759/cureus.99731
Curēus IF: 01.300Volume 17, Issue 12No.209Safety and Synergy of Capmatinib Plus Stereotactic Radiotherapy in MET Exon 14-Mutated Non-Small Cell Lung Cancer: A Case Report卡马替尼联合立体定向放疗治疗MET外显子14突变非小细胞肺癌的安全性及协同作用：病例报告DOI: 10.7759/cureus.99838
Circulation IF: 38.600Ahead of Print.No.210Association of Statin Discontinuation in Pregnancy With Maternal Cardiovascular Health and Birth Outcomes: A Nationwide Cohort Study妊娠期停用他汀类药物与孕产妇心血管健康及出生结局的关联：一项全国队列研究DOI: 10.1161/CIRCULATIONAHA.125.078919
Frontiers in health services IF: 02.700Volume 5, Issue No.211Factors influencing cardiovascular disease screening uptake and implementation strategies to enhance cardiovascular disease screening uptake in Singapore adults: a multi-method study protocol影响新加坡成人心血管疾病筛查参与度的因素及提升筛查参与度的实施策略：一项多方法研究方案DOI: 10.3389/frhs.2025.1677666
Diabetes Technol Ther IF: 06.300Ahead of Print.No.212Association of Continuous Glucose Monitoring Metrics with Incident Diabetic Retinopathy: A Real-World Long-Term Study连续葡萄糖监测指标与新发糖尿病视网膜病变的关联：一项长期真实世界研究DOI: 10.1177/15209156261416922
Diabetes Technol Ther IF: 06.300Ahead of Print.No.213Diagnostic Accuracy of Artificial Intelligence-Enabled Retinal Biomarkers for Detecting Type 2 Diabetes and Prediabetes Among Asian Indians [DART Study]人工智能视网膜生物标志物检测亚洲印度人2型糖尿病与前驱糖尿病的诊断准确性[DART研究]DOI: 10.1177/15209156261417296
Diabetes Technol Ther IF: 06.300Ahead of Print.No.214Accuracy of Dexcom One+ in Patients with Diabetes or Stress Hyperglycemia Hospitalized in Cardiac Intensive Care UnitDexcom One+在心脏重症监护室糖尿病或应激性高血糖患者中的准确性DOI: 10.1177/15209156251407717
Diabetes Technol Ther IF: 06.300Ahead of Print.No.215Automated Insulin Delivery Associated with Superior Glycemic Outcomes in Type 1 Diabetes: A Swedish National Registry Analysis自动化胰岛素输注与1型糖尿病更优血糖结局相关：一项瑞典国家注册研究分析DOI: 10.1177/15209156251414976
Diabetes Technol Ther IF: 06.300Ahead of Print.No.216Consistent Benefit of Control-IQ+ Automated Insulin Delivery Across a Range of Characteristics of Adults with Type 2 DiabetesControl-IQ+自动化胰岛素输注对2型糖尿病成人患者不同特征的一致益处DOI: 10.1177/15209156261416920
Diabetes Technol Ther IF: 06.300Ahead of Print.No.217The Effect of Automated Insulin Delivery Systems on Sleep Quality and Quantity in Type 1 Diabetes: A Systematic Review and Meta-Analysis自动化胰岛素输送系统对1型糖尿病患者睡眠质量与时间的影响：一项系统综述与荟萃分析DOI: 10.1177/15209156251411925
Diabetes Technol Ther IF: 06.300Ahead of Print.No.218Overcoming Closed-Loop System Limits: Diluted Insulin Improves Glycemic Control and Reduces Nighttime Hypoglycemia in Toddlers with Low Insulin Requirements克服闭环系统局限：稀释胰岛素改善低胰岛素需求幼儿的血糖控制并减少夜间低血糖DOI: 10.1177/15209156251414981
Diabetes Technol Ther IF: 06.300Ahead of Print.No.219Outcomes in United States Veterans on Insulin Pumps Following Rapid Deployment of Telehealth Care快速部署远程医疗护理后美国退伍军人胰岛素泵使用者的结局DOI: 10.1177/15209156251403561
Diabetes Technol Ther IF: 06.300Ahead of Print.No.220Clinical Impact of Continuous Glucose Monitoring in Noninsulin Treated Type 2 Diabetes: A Review连续葡萄糖监测在非胰岛素治疗2型糖尿病中的临床影响：一篇综述DOI: 10.1177/15209156251414980
Health education & behavior IF: 02.100Ahead of Print.No.221Eating Behavior Traits and Success in Dietary Changes in Men with Prediabetes - the T2D-GENE Intervention饮食行为特征与糖尿病前期男性饮食改变成功的关系——T2D-GENE干预研究DOI: 10.1177/10901981251411226
Wound repair and regeneration IF: 03.400Volume 34, Issue 1No.222Plain Radiography for Diagnosing and Monitoring Foot Osteomyelitis in Persons With Diabetes: Accuracy, Limitations and Clinical Utility平片放射学在诊断和监测糖尿病患者足部骨髓炎中的应用：准确性、局限性与临床效用DOI: 10.1111/wrr.70128
J Comp Eff Res IF: 02.500Ahead of Print.No.223Reshaping the cardiovascular continuum in the management of arterial and venous cardiovascular disease: a narrative review重塑心血管连续谱：动脉与静脉心血管疾病管理的叙事性综述DOI: 10.57264/cer-2025-0162
BMJ medicine IF: 10.000Volume 5, Issue 1No.224Physical activity types, variety, and mortality: results from two prospective cohort studies体力活动类型、多样性与死亡率：两项前瞻性队列研究结果DOI: 10.1136/bmjmed-2025-001513
Transgender health IF: 01.800Volume 10, Issue 6No.225The Role of Body Composition Assessment in Tailoring Gender-Affirming Treatment for Transgender/Gender Diverse Youth身体成分评估在定制跨性别/性别多元化青少年性别肯定治疗中的作用DOI: 10.1089/trgh.2022.0218
North Clin Istanb IF: 00.900Volume 12, Issue 6No.226Evaluation of sociodemographic and clinical characteristics of dermatochalasis patients: A retrospective epidemiologic study in a tertiary care eye clinic皮肤病患者的流行病学研究：一项三级眼科诊所的回顾性研究DOI: 10.14744/nci.2025.25936
Front Clin Diabetes Healthc IF: 02.200Volume 6, Issue No.227Improving self-care, HbA1c control, and quality of life in type 2 diabetes: a self-regulation intervention based on the individual and family self-management theory改善2型糖尿病自我护理、HbA1c控制及生活质量：一项基于个体和家庭自我管理理论的自律干预DOI: 10.3389/fcdhc.2025.1712334
MedComm IF: 10.700Volume 7, Issue 2No.228The Gut Microbiota as a Mediator in the Relationship Between Dietary Patterns and Depression肠道菌群作为膳食模式与抑郁症关系的中介DOI: 10.1002/mco2.70562
bioRxivVolume 2026, Issue No.229Harmine Selectively Drives Human Beta Cell Differentiation and Function Via Protein Kinase A PathwaysHarmine通过蛋白激酶A通路选择性驱动人类β细胞分化与功能DOI: 10.64898/2025.12.07.692818
Jornal Vascular Brasileiro IF: 01.000Volume 24, Issue No.230Incidence and risk factors for contrast-induced nephropathy after angioplasty: an observational retrospective study血管成形术后造影剂肾病的发生率与危险因素：一项回顾性观察研究DOI: 10.1590/1677-5449.202500282
Frontiers in oncology IF: 03.300Volume 15, Issue No.231KEAP1 mutations activate the NRF2 pathway to drive cell growth and migration, and attenuate drug response in thyroid cancerKEAP1突变激活NRF2通路驱动甲状腺癌细胞生长与迁移并减弱药物反应DOI: 10.3389/fonc.2025.1685379
Case Reports in Dentistry IF: 00.900Volume 2026, Issue No.232Refractory Gingival Enlargement: A Critical Oral Clue to Early-Stage Granulomatosis With Polyangiitis-A Case Report and Literature Review难治性牙龈肥大：早期肉芽肿性多血管炎的一个关键口腔线索——病例报告与文献回顾DOI: 10.1155/crid/8443058
FCVM IF: 02.900Volume 12, Issue No.233Clinical outcomes of aortic stenosis patients undergoing Impella-supported high-risk percutaneous coronary intervention主动脉瓣狭窄患者接受Impella支持的高风险经皮冠状动脉介入治疗的临床结果DOI: 10.3389/fcvm.2025.1638259
Curēus IF: 01.300Volume 17, Issue 12No.234A Literature Review of the Renal Manifestations in Pediatric Celiac Disease and Its Associated Clinical Implications儿童乳糜泻肾损伤表现及其临床意义的文献综述DOI: 10.7759/cureus.99773
Curēus IF: 01.300Volume 17, Issue 12No.235Hypertension and Risk of Stroke: A Systematic Review and Meta-Analysis高血压与卒中风险：一项系统性回顾与荟萃分析DOI: 10.7759/cureus.99863
Curēus IF: 01.300Volume 17, Issue 12No.236Exploring the Potential Observations Between Geomagnetic Activity and Cardiovascular Events: A Scoping Review探索地磁活动与心血管事件间的潜在关联：一项范围综述DOI: 10.7759/cureus.99851
Ther Adv Ophthalmol IF: 02.300Volume 18, Issue No.237Exploring hyperbaric oxygen therapy for central retinal artery occlusion beyond 24 h: case report探索高压氧疗法治疗超过24小时的中心视网膜动脉阻塞：病例报告DOI: 10.1177/25158414251405382
JIMD reports IF: 01.800Volume 67, Issue 1No.238Identification of Additional Cases of Severe Neonatal GABA-Transaminase Deficiency严重新生儿期GABA转氨酶缺乏症额外病例的识别DOI: 10.1002/jmd2.70069
Bioeng Transl Med IF: 05.700Volume 11, Issue 1No.239Vitrification and rapid rewarming of precision-cut liver slices for pharmacological and biomedical research用于药理学和生物医学研究的精密肝切片的玻璃化冷冻与快速复温DOI: 10.1002/btm2.70045
J Diabetes Metab Disord IF: 01.600Volume 25, Issue 1No.240AMPK as a central regulator of metabolic memory: mechanisms and therapeutic opportunitiesAMPK：代谢记忆的核心调节器——作用机制与治疗前景DOI: 10.1007/s40200-026-01859-x
Curēus IF: 01.300Volume 17, Issue 12No.241Spectrum of Cardiac Complications in Diabetic Patients in Rural Uttar Pradesh, India: A Hospital-Based Study印度北方邦农村糖尿病患者心脏并发症谱系：一项医院为基础的研究DOI: 10.7759/cureus.99734
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.242Case report: Takotsubo cardiomyopathy and cardiac arrest in a 9-year-old girl with new-onset diabetes presenting with diabetic ketoacidosis: the chicken or the egg?病例报告：新发糖尿病伴酮症酸中毒的9岁女孩发生Takotsubo心肌病与心脏骤停：孰因孰果？DOI: 10.3389/fendo.2025.1723428
Curēus IF: 01.300Volume 17, Issue 12No.243Ectopic Acromegaly Caused by Peripheral Ectopic Growth Hormone Hypersecretion: A Case Report and Literature Review异位肢端肥大症：一例外周异位生长激素过度分泌病例报告与文献回顾DOI: 10.7759/cureus.99840
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.244Prolonged alpha-blockade and doxazosin are associated with hypertensive crisis in pheochromocytoma surgery嗜铬细胞瘤手术中，延长α受体阻滞及使用多沙唑嗪与高血压危象相关DOI: 10.3389/fendo.2025.1682912
J Educ Health Promot IF: 01.300Volume 14, Issue No.245Maternal-physiological parameters and prenatal mindfulness interventions - A scoping review母体生理参数与产前正念干预——范围综述DOI: 10.4103/jehp.jehp_2061_24
217
Diabetes Mellitus(DM)
糖尿病
95
Obesity
肥胖症
87
Insulin
胰岛素
23
Type 2 diabetes mellitus(T2DM)
2型糖尿病
12
Metformin
二甲双胍
12
Metabolic Syndrome
代谢综合征
7
Semaglutide
司美格鲁肽
7
Diabetic Retinopathy
糖尿病视网膜病
6
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
6
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
5
Hypoglycemic Agents
降糖药
5
Diabetic Foot
糖尿病足
4
Liraglutide
利拉鲁肽
4
Type 1 diabetes mellitus(T1DM)
1型糖尿病
4
Tirzepatide
替尔泊肽
3
Diabetic Cardiomyopathies
糖尿病心肌病
3
Gabapentin
加巴喷丁
3
Pregabalin
普瑞巴林
3
Diabetic Peripheral Neuropathy(PDN)
糖尿病周围神经病变
2
Diabetic Neuropathies
糖尿病性神经病变
2
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
2
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
1
Vildagliptin
维格列汀
1
Dulaglutide
度拉糖肽
1
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
1
Empagliflozin
恩格列净
1
Ertugliflozin
艾托格列净
1
Ipragliflozin
依格列净
1
Diabetes Complications
糖尿病并发症
1
Diabetic acidosis
糖尿病性酸中毒
编辑：牛祥
审校：牛祥
临床结果临床研究
2026-01-19
·观生物
人类类器官（Human organoids） 是源于干细胞的 3D 体外模型，能精准复刻人体组织的关键结构与功能，相比传统 2D 细胞系和动物模型，在疾病建模、药物筛选、安全性评估中具有更高的生理相关性和转化价值；其主要分为多能干细胞（PS 细胞）衍生和组织干细胞（TSC）衍生两类，已广泛应用于遗传疾病、癌症、感染性疾病等领域的机制研究与个性化治疗探索，当前超 10 类器官的类器官模型已进入临床相关研究，但仍面临血管化 / 免疫细胞整合不足、标准化与可扩展性有限等挑战，随着微流控、自动化技术发展及监管框架完善，有望成为药物研发与精准医疗的核心工具。一、背景与核心概念1.1 技术演进与原理
类器官是源自干细胞的3D结构，能够重现对应组织的关键结构和功能特征。相比传统2D细胞系，类器官更接近人类生理状态，能够捕捉组织复杂性和异质性。技术起源于：
Mina Bissell的开创性工作：使用Matrigel实现乳腺上皮细胞的3D培养
多能干细胞（PS细胞）路线：1980年代胚胎干细胞（ES细胞）发现，2006年Yamanaka的iPS细胞技术突破，Sasai团队首次从PS细胞自发形成视网膜等CNS结构
组织干细胞（TSC）路线：2009年首次证明单个肠上皮TSC可形成包含所有肠细胞类型的类器官（Sato et al., Nature 2009）
人类类器官与传统临床前模型的比较1.2 两种主流生成路径
多能干细胞（PS）与组织干细胞（TSC）来源的人类类器官
核心流程：
PS路线：胚层特化→器官特异性分化→3D聚集自发组织
TSC路线：组织消化→Matrigel培养→生长因子驱动扩增二、疾病建模应用2.1 遗传病建模（精准医学突破）囊性纤维化（CF）
机制：CFTR基因突变导致氯离子通道功能丧失
类器官模型：肠/气道类器官Forskolin诱导肿胀试验，突变导致肿胀失败
临床转化：药物反应与临床ppFEV1和痰细胞计数高度相关（r>0.8）
应用：CRISPR修复CFTR突变、评估Trikafta（elexacaftor/tezacaftor/ivacaftor）疗效，罕见基因型预测原发性纤毛运动障碍（PCD）
模型：鼻气道类器官直接观察纤毛摆动，电子显微镜检测结构异常
基因治疗：Prime editing修复DNAH11突变表面活性物质缺乏症
SFTPB突变：iPS细胞来源肺类器官重现板层小体异常，基因治疗可挽救多囊肾病（PKD）
ADPKD（PKD1/2突变）：类器官自发形成囊肿，表达疾病特征基因谱
ARPKD（PKHD1突变）：器官芯片模拟流体剪切力，重现囊肿发生机制
药物筛选：喹唑啉类化合物抑制囊肿生长α1-抗胰蛋白酶缺乏症（AATD）
肝类器官：重现A1AT聚合、分泌减少、弹性蛋白酶抑制缺陷
治疗探索：基因疗法防止聚合物聚集威尔逊病（ATP7B突变）
胆管类器官：铜处理显示毒性积聚，模拟肝损伤（小鼠模型无法重现神经精神症状）胆道闭锁
病理特征：类器官显示空泡增多、增殖下降、极性紊乱、CFTR低表达
新发现：β-淀粉样蛋白沉积作为诊断标志物神经退行性疾病
帕金森病（DNAJC6突变）：中脑类器官显示多巴胺神经元发育障碍、α-突触核蛋白聚集、线粒体/溶酶体功能障碍（小鼠模型无法重现）
阿尔茨海默病（APOE4）：脑类器官显示Aβ和磷酸化tau升高、突触丢失、细胞凋亡
额颞叶痴呆（MAPT突变）：R406W突变导致tau错位、微管不稳定、线粒体运输障碍；V337M突变引发兴奋性毒性
脆性X综合征：FMRP缺失导致神经发生失调，PI3K通路抑制剂可挽救（mGluR5拮抗剂临床失败但动物模型有效）2.2 代谢性疾病代谢功能障碍相关脂肪性肝炎（MASH）
模型：iPS细胞来源肝类器官+FFA诱导，重现脂滴积聚、炎症因子（IL-6、TNF-α）上调、器官硬度增加
多细胞类器官：整合Kupffer细胞（KCs）和肝星状细胞（HSCs），模拟纤维化进程
药物筛选：索拉非尼减少脂肪性纤维化，镁补充无效（与临床争议一致）其他代谢病
家族性高胆固醇血症：iPS细胞来源肝细胞显示强心苷减少ApoB合成
线粒体DNA耗竭综合征：NAD治疗通过PGC1α恢复ATP水平2.3 慢性炎症性疾病炎症性肠病（IBD）
保留疾病特征：类器官维持炎症组织转录特征和表观遗传改变
免疫共培养：自体T细胞通过CD103和NKG2D浸润并诱导上皮死亡，抗体阻断可减轻损伤
疾病模型中的不同类器官乳糜泻（CeD）
器官芯片：气液界面培养保留黏膜免疫群体，IL-7是麸质诱导的关键致病介质自身免疫性甲状腺病
Graves病：TSHR自身抗体刺激类器官增殖和激素分泌
Hashimoto甲状腺炎：CCL2/CCL3趋化因子招募免疫细胞慢性阻塞性肺病（COPD）
类器官：显示杯状细胞增生、纤毛摆动频率降低
烟雾暴露：吸烟相关COPD类器官对烟雾更敏感2.4 感染性疾病肠道病原体
隐孢子虫：人肠类器官支持无性/有性生命周期，产生感染性卵囊
诺如病毒：首次体外人平台，识别肠细胞为靶标，血型抗原依赖性
轮状病毒、柯萨奇病毒、肠道病毒：完整生命周期模型寨卡病毒（ZIKV）
脑类器官：显示皮层破坏、神经前体细胞减少、小头畸形表型
机制：NS2A破坏放射状胶质细胞增殖，NS4A/NS4B抑制AKT-mTOR，NS5靶向人STAT2
药物筛选：hippeastrine hydrobromide、emricasan、niclosamide有效呼吸道病毒
SARS-CoV-2：气道类器官表达ACE2/TMPRSS2，模拟初始感染部位；肠道类器官支持病毒复制
关键发现：TMPRSS2是泛冠状病毒靶点，(羟基)氯喹无效（与临床一致）
流感：区分人源与禽源亚型感染性，评估H5N6/H5N8溢出风险
RSV/HRV-C：重现临床感染特征，用于抗病毒开发2.5 肿瘤建模与个性化医疗患者来源肿瘤类器官（PDTO）
成功率：几乎所有癌种可建立（结直肠癌成功率>80%）
保真度：保留原发肿瘤组织学、基因组和转录组特征，可异种移植
突变驱动生长：KRASG12V类器官可不依赖EGF生长，用于区分肿瘤/正常组织药物筛选成功案例
MCLA-158（petosemtamab）：完全基于结直肠癌PDTO筛选的EGFR×LGR5双抗，30个月从发现推进至I期，现处于III期（头颈癌）和II期（结直肠癌）
预测能力：胰腺癌（吉西他滨敏感性签名）、胃肠道癌（与患者治疗反应一致）、乳腺癌（HER2通路）、卵巢癌（铂类/紫杉醇）、胶质母细胞瘤（EGFRvIII CAR-T）
用于药物筛选与评估的代表性患者来源肿瘤类器官（PDTOs）生物样本库基因工程肿瘤模型
CRISPR序贯突变：在野生型类器官中引入APC、TP53、KRAS等突变，生成预期组织学肿瘤三、转化安全应用3.1 肝毒性（DILI）
高保真模型：PS细胞来源肝类器官（HLOs）重现曲格列酮、对乙酰氨基酚、曲伐沙星毒性，灵敏度高于2D肝细胞
基因型特异性：bosentan诱导的胆汁淤积性肝损伤显示供体间差异
表型覆盖：可建模脂肪变性、纤维化、免疫反应
胆管损伤：氯丙嗪诱导的胆管细胞毒性
基因治疗评估：AAV载体性能与靶向肝毒性平台3.2 肾毒性
急性肾损伤模型：含肾小球、近端小管、Henle袢、远端小管的类器官，顺铂/庆大霉素诱导剂量依赖性KIM1表达
免疫介导毒性：T细胞双抗（TCB）选择性杀伤WT1表达细胞
优化模型：微器官球、生物打印、器官芯片灌注PBMC3.3 胃肠毒性
腹泻预测：回肠类器官检测31种参比药物，准确率90%
机制解析：多柔比星/吉非替尼诱导的黏膜损伤
物种差异：人/大/犬类器官敏感性差异与临床前发现一致
TCB脱靶毒性：肠道PDTO+免疫细胞捕获临床不良反应3.4 CNS毒性
长春新碱：脑类器官揭示对脑发育的神经毒性，涉及ECM信号
曲安奈德：剂量依赖性神经元/星形胶质细胞损伤，通过BHC110/LSD1介导
化疗神经毒性：紫杉醇模型显示CNS毒性评估能力3.5 心脏毒性
多柔比星：降低活力、增加LDH/BNP、诱导凋亡/纤维化/线粒体功能障碍
器官芯片：肝-心脏共培养显示氯米帕明代谢物致心律失常
FDA召回药物：检测ATP耗竭和搏动中断优于2D单层
发育毒性：沙利度胺减少心脏组织形成
类器官系统在疾病建模与药物安全性评估中的应用
类器官在药物安全性评估中的应用四、基于类器官的吸收与代谢（ADME）检测4.1 肝代谢
酶表达：TSC来源肝类器官表达CYP3A4、CYP2D6、UGT、OATP1B3、ABCB1
多器官平台：肝-肠-肾芯片研究midazolam代谢、coumarin排泄
挑战：胆管类器官CYP表达低于原代肝细胞，需优化成熟度4.2 肠吸收与转运
2D transwell：从3D类器官铺开，支持双向转运研究，区分高/低渗透性化合物
外翻类器官：顶膜朝外，便于研究转运体和酶活性（CYP3A4、MDR1可被rifampicin诱导）
代谢活性：3D十二指肠/结肠类器官显示I/II期酶的区域特异性表达4.3 肾清除
近端小管芯片：类器官来源细胞显示OCT2/OAT1/OAT3，改善药物摄取
管状类器官：尿液来源，荧光罗丹明123验证转运功能4.4 采用挑战
成熟度不足：肝/肾分化不完全
动物研究惯性：简单动物PK研究仍占主导
规模化需求：需百万级细胞量模拟体内代谢五、当前挑战与解决方案5.1 生物学复杂性局限
缺乏血管化：限制营养/氧气输送，影响药物递送评估
无免疫细胞：无法研究炎症、免疫治疗反应
缺少基质/神经/力学信号：影响功能和疾病模拟
无系统互作：激素、多器官串扰缺失5.2 可重复性与标准化
变异来源：实验室间方案差异、供体遗传背景、分化异质性、分析工具复杂
解决方案：
自动化平台：微流控设备（Mimetas OrganoPlate、Emulate Liver-Chip）实现培养、加药、成像自动化
均一化培养：微孔阵列、微柱芯片控制大小/形状/细胞数，数千个类器官同步成像
悬浮培养：超低附板+旋转装置适用于脑/肝类器官5.3 规模化难题
常规方法：Matrigel包埋多孔板，手动操作变异大
工程化方案：
微流控液滴：高通量打印Matrigel包埋类器官，保留组织异质性
微孔阵列：分析肺癌类器官，1周内预测药物反应
组织微阵列：96孔类器官FFPE块，支持AI数字病理分析5.4 读out标准化
简单读out：CellTiter-Glo/MTT活力检测
疾病特异性：CFTR功能（肿胀试验）、A1AT分泌（ELISA）、脂滴积聚（荧光染料）、病原体RNA/蛋白
高内涵成像：自动化显微镜+计算机视觉量化形态、基因表达六、监管挑战与机遇6.1 监管框架演进
FDA现代化法案2.0/3.0（2022/2023）：明确动物试验非必需
FDA替代方法计划（2025）：逐步淘汰单抗等药物的动物测试
EMA安全港方法：自愿提交NAMs数据，定义context of use6.2 采用障碍
监管接受度：需证明优于传统方法，当前多为探索性研究
模型验证：需OECD指南（GD34、GIVIMP、GD211）描述的表征和验证
成本效益：构建维护需高投入的设备和人才6.3 未来路径
跨行业合作：FDA、EMA、制药企业、CRO共同制定标准
分阶段整合：早期内部决策→监管申报，逐步替代/减少/优化动物模型
外包策略：CRO提供专业服务，降低单家企业负担
自动化高通量药物筛选策略七、结论与展望
核心价值：类器官填补了2D细胞系与动物模型之间的空白，提供生理相关、可规模化、患者特异性的人体模型，在遗传病精准医疗、感染病机制、肿瘤个性化治疗中已显示变革潜力。
关键瓶颈：血管化、免疫系统整合、多器官互作、力学刺激、标准化自动化。
技术趋势：
血管化：内皮细胞共培养、3D生物打印
免疫化：肿瘤类器官+自体免疫细胞研究免疫治疗
多器官芯片：body-on-a-chip模拟系统药代动力学
AI驱动：数字病理、单细胞组学整合分析
监管前景：随着FDA Modernization Act实施和EMA NAMs路径成熟，未来3-5年类器官有望在特定适应症（如DILI、罕见病）成为监管认可的标准工具，最终革命化药物发现流程，缩短研发周期，降低临床失败率。
https://doi.org/10.1038/s41573-025-01317-y
基因疗法
2025-12-22
医道社：传承和发展民间中医
来源：海外网站 作者：医道社整理
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大家好，我是你们的创新药专业博主。今天咱们来聊聊Vertex Pharmaceuticals（纳斯达克：VRTX），这家公司在临床和研发圈子里越来越火了。作为临床医生和药品研发人员，你们肯定对它的CF霸主地位耳熟能详，但Vertex的野心远不止于此。它正从单一罕见病王者，悄然转型成一个跨基因编辑、细胞疗法、肾病和疼痛管理的多领域帝国。2025年12月20日，VRTX股价收于约456美元，整个12月涨幅明显，尤其是12月3日近7%的暴涨和12月6-10日的ASH年会数据发布后，市场情绪被彻底点燃。
为什么说这不是炒作？因为Vertex用数据和里程碑说话：Casgevy的儿科突破、肾脏管线的加速推进、Journavx的商业化爬坡，还有Zimislecel在T1D的颠覆潜力。这些不是科幻，而是基于真实临床试验、FDA更新和财报的铁证。作为一线从业者，你们会看到Vertex如何通过对疾病生物学的深刻理解，构建技术护城河，复制CF的成功 playbook。咱们一步步拆解，结合ASH 2025数据、NEJM论文和分析师报告，确保每点都站得住脚。读完这篇，你会对Vertex的研发逻辑有全新认识——它不只是卖药，而是重塑遗传病治疗范式。第一部分：CF基础——“印钞机”的底气与“成长烦恼”，多元化转型的起点
Vertex的崛起，从囊性纤维化（CF）开始。这不是运气，而是对CFTR蛋白病理的系统性深挖。从2012年的Kalydeco（VX-770，小分子激活CFTR通道），到Orkambi、Symdeko，再到2019年的Trikafta（三联疗法，Elexacaftor/Tezacaftor/Ivacaftor），Vertex把CF从“不可治”变成“可控慢性病”。核心逻辑？精准分型+组合策略，将可治疗人群从部分突变扩展到90%以上患者。
2025年Q3财报亮眼：CF产品收入28.7亿美元（YoY+9%），全年指引上调至119-120亿美元，总营收30.8亿美元（YoY+11%），调整后EPS 4.80美元，超预期。Trikafta全球销售额超100亿美元，渗透率90%，毛利率80%以上，ROE高达40%。现金储备超120亿美元，Q3经营现金流14亿美元——这让Vertex成了生物科技界的“现金奶牛”，不像Moderna那样负债累累（2025年亏损超10亿美元）。
但成功也有烦恼：CF患者全球仅7-8万，高定价（370k美元/年）引发争议。Fierce Pharma 2025报道的“买家俱乐部”事件——孟加拉仿制Trikafta仅12k美元，虽在美国非法进口，但像一根刺，提醒定价压力（CMS 2026国际基准试点）。更重要的是，投资者追问：CF专利悬崖（Trikafta 2039到期）后呢？Vertex的答案是Alyftrek：2025年7月欧盟批准、12月FDA批准，扩展至6岁+患者，更高效、更安全，生命周期管理极致化。这不只防御仿制，还下沉年轻患者群，减少进行性损伤。
作为临床医生，你们知道CF越早干预越好；研发者则看到Vertex的 playbook：从基础研究穿透基因型–表型–功能缺陷，再用小分子组合滚动更新。CF占营收70%，但已贡献“军火库”——20亿美元+研发投入，支撑多元化。肾病、基因编辑等新领域，正是用CF现金复制“序列化统治”。第二部分：基因编辑的“王权确立”——Casgevy儿科数据震撼，平台价值的起点
如果CF是“旧大陆”，Casgevy就是Vertex征服“新大陆”的滩头堡。这款与CRISPR Therapeutics合作的CRISPR/Cas9基因疗法（exagamglogene autotemcel），2023年12月FDA首批准用于12岁+ SCD和TDT患者，标志人类首次商业化基因编辑。
2025年ASH年会（12月6-10日）儿科数据，是临床界的里程碑：CLIMB-151（SCD）和CLIMB-141（TDT）3期试验，5-11岁儿童组。
·SCD儿童：11名患者治疗，4名足够随访，100%达到VF12（至少12个月无VOC），最长24.1个月。历史对比：SCD患者年VOC 3-4次，中位寿命45岁，剧痛+器官损伤。Casgevy重启HbF，红细胞功能恢复，让孩子“重获新生”。
·TDT儿童：13名患者，6名足够随访，100% TI12（12个月输血独立，Hb≥9 g/dL），最长22.5个月。TDT以往每月输血，铁过载，中位寿命37岁——Casgevy切断“枷锁”。
成人长期随访更稳：SCD 45/45 VF12，平均35.3个月（12.9–67.7）；TDT 55/56 TI12，平均41.4个月（13–72.3）。安全性与成人一致，主要风险从预处理化疗（白消安），一例TDT患儿死于VOD并发多器官衰竭。但Vertex强调，这匹配自体移植标准，基因编辑部分干净：HbF稳定上升，等位基因编辑80%以上。Carmen Bozic博士在ASH直言：“儿科里程碑，我们计划2026年上半年全球sBLA，已获FDA优先审评券，审查1-2个月。”
为什么震撼？全球SCD/TDT超30万，儿科40%以上。定价220万美元/疗程，一次性，峰值销50亿美元/年（Evaluate Pharma）。2025年Q3收入1.69亿美元，治疗中心从10扩至30，物流优化（采集到输注6个月），获批11国（欧盟、加拿大等）。对比Bluebird的Zynteglo（仅TDT，销<1亿美元），Vertex的供应链和伙伴网络（如小野药品）如虎添翼。
临床视角：疗效“接近治愈”，但复杂流程（清髓+移植）需专业中心，风险高。研发者看重：Casgevy验证BCL11A编辑安全性，可扩展其他血液病。它不是“一锤子”，而是平台起点——Vertex从病理链条反推工具（体外编辑修复下游缺陷），证明基因编辑的工程化能力。儿科扩展若成，打开百亿蓝海，股价或奔550美元。第三部分：肾病“第二增长引擎”——Povetacicept领衔，复制CF王朝的系统布局
肾病市场超1000亿美元，IgAN和APOL1介导肾病患者超500万，未满足需求巨大。Vertex视其为“下一个CF”，投资超20亿美元，布局小分子+生物制剂，精准靶向（eGFR稳定>90%）。BioSpace 2025报道：肾脏叙事吸引养老基金增持5%。
·Povetacicept (VX-147)：双靶点（BAFF/APRIL）融合蛋白，阻断B细胞通路。2025年11月FDA IgAN突破性疗法认定。3期RAINIER（n=500+）完成招募，48周数据：IgAN UPCR降64%，eGFR稳定；pMN降82%。36周中期支持加速路径，计划2025年上半年滚动BLA+优先审评券。小野药品确认日本路径。峰值销30-50亿美元（Jefferies）。
·Inaxaplin：APOL1小分子抑制剂，针对遗传肾病（非洲裔肾衰率10倍高），2025年Q3 3期入组完成，II期蛋白尿降50%、肾功能保全。
·VX-407：ADPKD II期启动，覆盖多囊肾。
Vertex playbook：理解根源（CFTR vs. APOL1/BAFF通路），建产品矩阵，谋求统治。IgAN/pMN现有药碎片化（SGLT2i、RTX等），Povetacicept的“黄金公式”（高降蛋白尿+eGFR稳定）若获批，将成跨适应症平台。2028年，肾病或贡献营收30%以上，远超CF专利风险。
临床医生：这些药针对免疫/遗传驱动，安全性好，eGFR保全关键。研发者：多靶点+系统工程，扩展到其他肾小球病，护城河深。第四部分：疼痛与T1D的横向拓展——Journavx商业考验，Zimislecel“登月计划”
·Journavx (VX-548)：非阿片NaV1.8抑制剂，急性疼痛缓解>70%（III期），避阿片成瘾。2025年3月NDA提交，获批上市。Q3销2亿美元（部分报道1960-2000万），处方30万+，覆盖1.7亿保险。路透社：早期挫折（一适应症取消，8月股价回调），但转化加速，峰值20亿美元。政策顺风（阿片危机），但收入滞后（免费药、payer摩擦）是考验。从“高价罕见”到“大市场+payer精耕”，执行力大考。
·Zimislecel (VX-880, T1D细胞疗法)：NEJM 2025论文：12名患者，83%（10/12）无需胰岛素，“功能性治愈”。干细胞诱导β细胞，移植恢复功能，现需免疫抑制，未来豁免化。T1D市场千亿级，低血糖+并发症痛点大。计划2026年监管申请，并列Povetacicept为重点。临床震撼：摆脱胰岛素依赖；研发：遗传功能重构，标准化制造是关键。若成，Vertex从CF龙头变“遗传+细胞平台巨头”。第五部分：技术底座与公司优势——“选靶心态”+战略纪律，铸就护城河
Vertex护城河不是CF，而是对遗传病“功能重构”的系统理解+多工具切换（小分子、CRISPR、细胞）。从CF病理穿透，到SCD/TDT（BCL11A编辑）、T1D（β细胞恢复）、肾病（APOL1抑制），始终聚焦高置信度疾病，避免发散（如肿瘤异质性）。
公司优势：战略聚焦（遗传/免疫边界内增量）、管线纪律（砍VX-993等不达标，8月疼痛调整虽回调但护资产）、财务自由（无杠杆，自有现金玩长线，研发支出22.4亿美元，占24.2%）。制造/商业化强：Casgevy端到端网络，专业团队+患者援助。三大核心：序列化统治、科学驱动+商业无情、金融堡垒。
风险：CF依赖（2028前主体，政策/舆论压力）；基因/细胞执行马拉松（预处理毒性、供应链、免疫抑制，安全事件敏感）；商业转化（处方≠收入，组织升级需时）。第六部分：分析师展望——华尔街集体看涨，2026催化剂兑现
2025年12月，22位分析师共识目标价494美元（StockAnalysis），上涨8%；MarketBeat“适度买入”，平均498美元。摩根士丹利12月3日“增持”564美元，强调肾脏引擎；富国银行12月10日515美元，重申乐观。Benzinga 26位共识497美元，焦点Casgevy儿科+肾脏。MarketBeat追踪类似。
2026关键：Casgevy儿科批准+增长曲线；Journavx payer模式；Povetacicept滚动BLA；Zimislecel审评。短期450-500美元博弈节奏，中期3-5年多引擎估值，长期“遗传重建”范式。结语：Vertex的“核聚变”时刻——临床与研发的启示
Vertex不是“赌”未来，而是“造”未来。从CF垄断，到Casgevy验证、肾病矩阵、Journavx/T1D拓展，它证明：深挖病理+平台化，能改写大分子时代。临床医生：这些疗法重塑标准，关注儿科/蛋白尿数据；研发者：选靶从机制反推，聚焦确定性疾病，建可复制 playbook。
作为博主，我认为Vertex的转型已从“是否”变“规模+速度”。数据说话：ASH儿科100%终点、Povetacicept 64%降蛋白尿、Zimislecel 83%独立——震撼吧？欢迎留言分享你的临床/研发心得，关注公众号，更多深度解析。
（数据来源：Vertex Q3 2025财报、ASH 2025摘要、FDA/NEJM公告、路透社/BioSpace/Fierce Pharma 2025报道、分析师共识2025年12月更新。本文基于公开信息专业分析，仅供临床医生和药品研发人员参考学习，不构成任何投资或医疗建议。投资有风险，DYOR；医疗决策请咨询专业医师。）
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 囊性纤维化 | 临床3期 | 美国 | 2016-11-01 | |
| 囊性纤维化 | 临床3期 | 加拿大 | 2016-11-01 |
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
N/A | - | - | 簾顧製觸鑰遞衊遞製選(鑰廠廠衊憲襯觸壓獵鏇) = 艱網鹹窪鏇構構窪膚鬱 窪願齋蓋壓鏇顧艱選艱 (願鑰壓鬱鹹鏇網齋遞醖 ) | - | 2025-05-16 | ||
簾顧製觸鑰遞衊遞製選(鑰廠廠衊憲襯觸壓獵鏇) = 壓廠襯廠選廠糧蓋鏇構 窪願齋蓋壓鏇顧艱選艱 (願鑰壓鬱鹹鏇網齋遞醖 ) | |||||||
| - | 971 | 遞獵鑰鏇遞餘積構構衊(製鏇糧艱糧鹹鏇獵衊構) = 与安慰剂对比，使更多患者免于长期严重残疾 簾顧構鑰廠鏇憲繭選廠 (製壓構壓窪窪選艱襯範 ) 更多 | 积极 | 2024-02-05 | |||
临床3期 | 83 | 壓醖簾壓鑰淵製糧網鏇(鏇餘獵鏇積鏇製顧蓋夢) = 網膚鏇願範獵襯壓襯網 淵製艱衊願衊範選範觸 (夢顧齋鏇膚繭壓鑰築窪, 10.3) 更多 | - | 2019-12-05 | |||
選鬱壓淵獵網築鑰鹽範 = 憲築襯廠鏇簾蓋艱餘簾 築簾夢襯範壓顧繭憲齋 (衊鏇艱顧鏇襯鏇積淵顧, 鹽遞顧網簾壓醖鹹糧遞 ~ 簾願網膚廠製繭窪壓積) 更多 | |||||||
临床3期 | 70 | 網糧繭顧衊鏇夢繭窪獵(壓鹹構顧憲鑰淵鏇膚築) = 襯積糧願艱網齋繭衊觸 夢獵獵夢製築艱獵憲範 (鏇願鏇蓋廠餘製艱窪衊 ) | 积极 | 2019-09-01 | |||
临床2期 | 40 | 糧鬱鏇淵遞鏇網構製壓 = 繭廠廠範鹽廠蓋範鹹憲 製網願廠憲艱鏇憲簾構 (艱餘觸築窪鏇網鏇艱襯, 網鏇鬱餘製鑰齋鹹憲選 ~ 壓鏇餘壓衊鏇獵蓋積觸) 更多 | - | 2018-04-13 | |||
糧鬱鏇淵遞鏇網構製壓 = 構觸構鏇壓餘鹹窪糧願 製網願廠憲艱鏇憲簾構 (艱餘觸築窪鏇網鏇艱襯, 構壓鹽蓋醖顧構廠夢遞 ~ 糧蓋艱廠網糧窪醖醖遞) 更多 |
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