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更新于：2026-02-27
Doxycycline
多西环素
更新于：2026-02-27
概要
基本信息
简介Doxycycline是一种广谱抗生素，常用于治疗多种细菌感染症，如痤疮、肺炎和腹泻等疾病。它属于四环素类抗生素，通过抑制细菌蛋白质的合成来发挥作用。Doxycycline以口服或注射剂型供应，吸收迅速且耐受性良好。它可能会引起一些副作用，如恶心、呕吐和头晕等。作为研究和开发研究人员，需要注意的是，Doxycycline正在被研究用于治疗其他疾病，例如痛风和自闭症等疾病，但仍需进一步研究来确定其效果。 |
药物类型 小分子化药 |
别名 Doxycycline、Doxycycline (USP)、Doxycycline hydrate + [7] |
作用方式 抑制剂 |
作用机制 30S subunit抑制剂(30S核糖体亚基抑制剂) |
非在研适应症 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1967-12-06), |
最高研发阶段(中国)临床1期 |
特殊审评- |
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结构/序列
分子式C22H26N2O9 |
InChIKeyXQTWDDCIUJNLTR-CVHRZJFOSA-N |
CAS号17086-28-1 |
关联
152
项与 多西环素 相关的临床试验NCT07361926
Sexual Health Access at Retail Pharmacies: Advancing Pharmacy-based Delivery of Primary STI and HIV Prevention for Cisgender Women
This proposed 3-arm randomized study will compare different pharmacy based approaches that include HIV prevention medication (PrEP and PEP), routine STI testing, and preventive antibiotic (doxycycline) for STIs. The study will assess how well these services can be implemented, how acceptable they are to young women, and whether they are cost-effective.
开始日期2026-05-01 |
申办/合作机构 |
NCT06452394
NEODOXy: Targeting Cancer Stem Cells With NEOadjuvant DOXYcycline in Patients With Early Estrogen Receptor Positive / Human Epidermal Growth Factor Receptor 2- Negative Breast Cancer. A Prospective, Multicenter, Single Arm, Open Label Phase II Trial
Despite modern surgical and medical treatments, breast cancer can re-occur and lead 20% of patients to death. During the last 20 years, pre-clinical studies have shown that treatment failures may be due to the presence of a sub-type of cancer cells, the cancer stem cells, which are resistant to chemotherapy and radiotherapy. By chance, doxycycline, an old, inexpensive and safe molecule seems to target effectively these cancer stem cells. This study proposes to check for the clinical efficacy of doxycycline to target the cancer stem cells and improve the response to neoadjuvant chemotherapy in ER+/HER2- breast cancers.
开始日期2025-07-16 |
申办/合作机构- |
NCT06915688
Comparison of Clinical Cure Rate of Doxycycline and Levofloxacin in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
This study will include patients with chronic obstructive pulmonary disease (COPD) who present with an acute exacerbation. Participants will be randomly assigned to receive either doxycycline or levofloxacin for 5 days. The aim is to compare how effective each antibiotic is in improving symptoms after 2 days of treatment.
开始日期2025-04-15 |
申办/合作机构 |
100 项与 多西环素 相关的临床结果
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100 项与 多西环素 相关的转化医学
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100 项与 多西环素 相关的专利（医药）
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20,816
项与 多西环素 相关的文献（医药）2026-12-31·JOURNAL OF DERMATOLOGICAL TREATMENT
From signal to strategy: a disproportionality analysis of dupilumab-associated rosacea in FAERS with a summary of reported clinical cases
Review
作者: Yang, Xuefan ; Ruan, Dandan ; Chen, Xiang ; Li, Sitong ; Lin, Jiacheng ; Qiu, Xinlan ; Li, Jiaqi ; Ju, Qiang ; Mo, Xiaohui
PURPOSE:
Emerging evidence suggests rosacea as a recognizable adverse event during dupilumab therapy. This study aimed to investigate the potential association between dupilumab and rosacea using pharmacovigilance data and to characterize the clinical features of dupilumab-associated rosacea (DAR) through a review of reported cases.
MATERIALS AND METHODS:
We utilized the FDA Adverse Event Reporting System (FAERS) database (2017-2024) to identify disproportionality signals using four methods: Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Information Component (IC), and Empirical Bayesian Geometric Mean (EBGM). To contextualize these findings, we performed a focused narrative review of 8 publications comprising 10 DAR cases with extractable individual data.
RESULTS:
A significant disproportionality signal was identified across all four methods (ROR 3.873; PRR 3.872; IC 1.865 with IC025 1.653; EBGM 3.642), with reports predominantly in adults and females. In the case review, a consistent phenotype emerged: papulopustules on persistent centrofacial erythema with frequent burning; facial predominance with occasional extension to neck, scalp, or upper trunk; frequent Demodex detection by scraping, KOH, or in vivo imaging; and occasional granulomatous histology. Onset ranged from approximately 2 weeks to 21 months, including one post-discontinuation case. Most patients improved with rosacea-directed therapy (topical ivermectin or metronidazole; anti-inflammatory-dose doxycycline). However, dechallenge or rechallenge patterns and the need for dose-interval extension, temporary interruption, or switching biologic (e.g., lebrikizumab, upadacitinib) in a subset support a drug-related pattern at the reporting level.
CONCLUSIONS:
DAR represents a distinct clinical entity from dupilumab-associated head and neck dermatitis, which is eczematous and typically responds to antifungals or calcineurin inhibitors. While disproportionality signals indicate association rather than incidence or causality and are subject to reporting bias, clinicians should be aware of this potential adverse event to ensure appropriate management.
2026-12-31·European Clinical Respiratory Journal
Lung abscess as an adverse effect of Risankizumab
Article
作者: Kazi, Zarif ; Donenfeld, Thai ; Pascal, William ; Jesin, Stuart ; Clements, Kevin ; Lewis, Toni-Ann ; Ghimire, Samir
Background:
Risankizumab is used for prolongated duration by patients, necessitating further research to characterize the infectious risks involved.
Case Presentation:
A 30-year-old man on Risankizumab for psoriasis and alopecia presented with pleuritic chest pain, cough, hemoptysis, fever, and myalgias. Initial computed tomography (CT) scan showed a 4.9 × 7.7 × 6.1 cm irregular cavitary lesion in the medial right lower lobe with thickened walls and surrounding ground-glass opacification. Tuberculosis was ruled out with 3 negative acid-fast bacilli (AFB) samples and 2 negative samples for Mycobacterium tuberculosis and rifampin resistance assay (Xpert MTB/RIF). Empiric antibiotic therapy was initiated, though the patient remained persistently febrile and tachycardic despite reported symptomatic improvement. A repeat CT scan showed compression atelectasis of the right middle and lower lobes, and a large right pleural effusion with multiple air-fluid levels. The patient underwent a video-assisted thoracoscopic surgery (VATS) decortication. Pleural fluid culture grew methicillin-resistant Staphylococcus aureus, and sputum AFB culture from admission grew Mycobacterium avium three weeks after collection. The patient ultimately completed two weeks of oral doxycycline.
Conclusion:
Given the lack of notable risk factors for lung abscess, this case suggests a possible association with Risankizumab, which may have contributed to immunosuppression.
2026-06-01·JOURNAL OF INVERTEBRATE PATHOLOGY
Doxycycline-mediated clearance of Wolbachia is associated with the long-term survival of Diaphorina citri cell lines
Article
作者: Tavares, Clebson S ; Wu, Ke ; Bonning, Bryony C
Diaphorina citri transmits the causal agent of huanglongbing. We previously established three continuous D. citri cell lines, two of which (Dici1 and Dici5) harbor Wolbachia and Diaphorina citri reovirus (DcRV). Here we demonstrate that Wolbachia infection of these cell lines is associated with marked cytopathological effects, including culture collapse. Doxycycline treatment reduced Wolbachia titers and prevented further collapse, while DcRV levels remained unchanged, indicating that Wolbachia does not influence DcRV replication. Prolonged doxycycline treatment nearly eliminated Wolbachia, resulting in increased stability of the Dici1 and Dici5 cell lines. These cell lines with reduced Wolbachia loads represent improved systems for investigating host-microbe interactions.
297
项与 多西环素 相关的新闻（医药）2026-02-26
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中国抗癌协会肿瘤药物临床研究专业委员会, 中国抗癌协会标准建设委员会. 乳腺癌PAM通路抑制剂不良反应管理专家共识(2026版)[J]. 中华肿瘤杂志, 2026, 48(2): 183-195. DOI: 10.3760/cma.j.cn112152-20251110-00558 .
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摘 要
磷脂酰肌醇3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白（PAM）通路是调控细胞增殖、存活和代谢的关键信号网络，在乳腺癌的发生发展中发挥核心作用。PAM通路抑制剂为乳腺癌患者提供了精准治疗的新选择，然而其对正常组织生理功能的广泛抑制，会伴随一系列不良反应的发生。此外，由于不同PAM通路抑制剂作用靶点各异，不良反应谱也存在显著差异。鉴于PAM通路抑制剂不良反应谱的复杂性和管理的特殊性，中国抗癌协会肿瘤药物临床研究专业委员会和中国抗癌协会标准建设委员会共同制定了PAM通路抑制剂不良反应专家共识，系统梳理PAM通路抑制剂相关不良反应的流行病学特征、病理机制与风险因素，为临床医师提供了规范化的预防、监测、评估、管理、干预策略和方案，以期最大程度保障乳腺癌患者的用药安全，提高治疗依从性，最终提升抗肿瘤治疗效果与患者生存质量。
【关键词】乳腺肿瘤；PAM通路；不良反应；专家共识
目前，美国食品药品监督管理局（Food and Drug Administration， FDA）已批准4种磷脂酰肌醇3-激酶（phosphatidylinositol 3-kinase， PI3K）/蛋白激酶B（protein kinase B， Akt）/哺乳动物雷帕霉素靶蛋白（mammalian target of rapamycin， mTOR）信号通路（简称PAM通路）抑制剂用于治疗乳腺癌，包括伊那利塞、阿培利司、卡匹色替及依维莫司，其中伊那利塞、卡匹色替和依维莫司已获我国批准。中国抗癌协会肿瘤药物临床研究专业委员会和中国抗癌协会标准建设委员会组织专家，针对目前已在我国获批上市的3种PAM通路抑制剂需特别关注的不良反应或常见一般不良事件进行讨论并提出管理建议，以供临床医师参考。
推荐意见 1
大多数PAM通路抑制剂的不良反应源于其对PAM通路的广泛抑制，影响正常组织的生理功能。靶点选择（如PI3K、Akt和mTOR）、药物作用机制以及药代动力学特性等因素共同决定了不同的不良反应谱。
推荐意见 2
高血糖是PI3K抑制剂最常见的不良反应，治疗前应检查空腹血糖（fasting plasma glucose, FPG）、餐后2 h血糖（postprandial plasma glucose, PPG）和糖化血红蛋白（hemoglobin A1c， HbA1c）水平，以便充分评估高血糖的发生风险。治疗期间，建议根据各药品说明书定期进行监测。对于已确诊高血糖的患者，应严格按照分级处理，启用降糖药物。在治疗前和治疗期间定期检测肾功能，以指导PAM通路抑制剂剂量调整及降糖药物选择。1级高血糖无需调整剂量；≥2级时，应严格按照各药物说明书进行剂量调整或暂停用药，并及时进行以二甲双胍为基础的抗高血糖药物治疗，必要时联合内分泌科共同制定管理策略。基于血糖控制稳定情况，重新制定后续用药方案。
推荐意见 3
口腔炎常见于mTOR抑制剂，建议治疗前及治疗后第2、4和8周对患者进行临床监测和口腔评估。对于轻度口腔炎，建议指导患者避免使用含酒精和过氧化氢衍生物的药物，并予营养支持。对于重度口腔炎，可使用局部麻醉剂、糖皮质激素、生长因子等或考虑全身用药。1级口腔炎无需调整剂量；2～3级时，应暂停用药并加强口腔护理，必要时请口腔科会诊，待恢复至1级后以相同剂量或降低1个剂量水平恢复治疗；4级时考虑永久停药。
推荐意见 4
皮疹多见于PI3K/Akt抑制剂，其中Akt抑制剂发生率相对更高，需密切监测患者皮肤状态，避免接触刺激性护肤品。1级皮疹无需调整剂量，可局部使用糖皮质激素；2～3级时，应暂停用药并请皮肤科会诊，待恢复至1级后以相同剂量或降低1个剂量水平恢复治疗；4级时永久停药。
推荐意见 5
腹泻在Akt抑制剂中发生率较高，通常发生在治疗早期。治疗前需评估患者的胃肠功能，胃肠功能异常者需谨慎用药。1级腹泻无需调整剂量，可预防性使用止泻药；2～3级时，应暂停用药，待恢复至1级后以相同剂量或降低1个剂量水平恢复治疗；4级时永久停药。腹泻反复发生者，排除感染后可使用洛哌丁胺控制，必要时给予补液和电解质支持治疗。
推荐意见 6
血液学不良反应（以中性粒细胞症为主）是PAM通路抑制剂的不良反应之一，但发生率较低，绝大多数可以在治疗暂停、减量或终止治疗后恢复。治疗前需进行血常规检查，频率为每2周1次；治疗期间每个周期的第1天和第15天监测血常规，有临床指征时增加监测频次。≤2级中性粒细胞减少症，无需调整剂量；若出现3级中性粒细胞减少症伴发热或4级中性粒细胞减少症，需要立刻停药，待恢复至≤2级后可降低1个剂量给药。可考虑使用粒细胞集落刺激因子（granulocyte colony-stimulating factor, G-CSF）治疗，并请血液科会诊制定个体化方案。
推荐意见 7
肝损伤也是PAM通路抑制剂的不良反应之一。使用可能引发肝损伤的药物前需检测转氨酶和胆红素水平，评估基线肝功能。建议前3个月每2周检测1次，随后3个月每1周检测1次，此后每1～3个月检测1次，有临床指征时增加监测频次。1级转氨酶升高无需剂量调整；若出现2～3级转氨酶升高，需暂停用药，直至恢复至≤1级后以相同剂量或降低1个剂量水平恢复治疗；4级时永久停药。
推荐意见 8
发生非感染性肺炎是使用mTOR抑制剂的潜在风险。当患者出现呼吸道症状时，应立即根据临床指征尽早行胸部薄层CT等影像学检查。1级非感染性肺炎无需剂量调整；若发生2～3级非感染性肺炎，需暂停用药，并考虑皮质类固醇治疗，待恢复至≤1级后以降低1个剂量水平恢复治疗，若4周内未恢复则终止治疗；4级时永久停药。
一
PAM通路抑制剂简介与关键研究结果
PAM通路是调控细胞增殖、存活、代谢和蛋白合成的核心信号通路，其中PI3K是位于PAM通路上游源头的重要靶点，由PIK3CA基因驱动激活，可调节Akt/mTOR和多个其他下游信号靶点。PAM通路突变以PIK3CA突变最为常见，并且在乳腺癌各亚型中均有发生，其中激素受体（hormone receptor， HR）阳性、人表皮生长因子受体2（human epidermal growth factor receptor-2， HER-2）阴性乳腺癌PIK3CA突变率最高。PAM通路抑制剂是一种针对PAM信号通路的靶向治疗药物，通过抑制PI3K、Akt或mTOR的活性阻断信号传导，从而抑制肿瘤细胞增殖和存活。
PAM通路抑制剂在乳腺癌治疗领域的研发历经曲折，面临着多靶点抑制、安全性问题等诸多挑战。21世纪初，第1代PI3K抑制剂和mTOR抑制剂因单药疗效低、不良反应严重未能广泛应用，但也取得了零星突破，例如依维莫司用于HR+ HER-2-晚期乳腺癌后线治疗（2012年7月获美国FDA批准，2022年2月获中国批准）。既往关于PAM通路抑制剂的探索，多数为广泛PI3K抑制剂，均无法达到理想的获益-风险平衡，未广泛应用于临床实践，2010年后研究重点由广泛抑制剂转向亚型选择性抑制剂。PI3Kα特异性抑制剂阿培利司治疗显示出一定疗效，但由于安全性问题限制了其广泛应用。Akt抑制剂因疗效不足和耐药问题导致研发屡屡受挫。然而，PAM通路抑制剂的精准研发之路从未止步。历经近40年，卡匹色替2023年11月获美国FDA批准上市，2025年4月在我国获得批准上市。伊那利塞2024年10月获美国FDA批准上市，2025年3月在我国获得批准上市。伊那利塞属于新型PI3Kα抑制剂，具有高选择性抑制PI3Kα与特异性降解PI3Kα突变蛋白的独特双重作用机制。目前，乳腺癌PAM通路靶向治疗药物研发主要聚焦于PI3Kα或下游节点，STX-478、RLY-2608、LOXO-783等10余种PAM通路抑制剂已进入临床试验阶段。截至2025年8月，获批乳腺癌适应证的PAM通路抑制剂见表1，其在晚期乳腺癌中的关键研究数据见表2。
二
PAM通路抑制剂不良反应的发生机制
PAM通路广泛参与正常细胞的代谢、增殖、存活和免疫调节等重要生理过程，PAM通路抑制剂在通过靶向PI3K、Akt或mTOR信号节点抑制肿瘤生长的同时，不可避免地会干扰人体正常生理功能。特异性更高的抑制剂能够更精确地作用于突变的亚型，不良反应谱通常较窄，而泛抑制剂会抑制所有亚型，导致不良反应谱扩大。
1. 高血糖：PI3K/Akt信号通路参与调节多种生理过程，包括葡萄糖代谢、细胞生长、分化、增殖和存活，受到抑制会导致多组织糖代谢紊乱，从而引发高血糖。Akt激酶是体内调控葡萄糖转运的重要分子，通过调控葡萄糖转运蛋白（glucose transporter 4， GLUT4）至细胞膜，影响血糖转运。胰岛素通过PI3K/Akt通路促进GLUT4从囊泡转运至细胞膜，介导骨骼肌、脂肪的葡萄糖摄取。PI3K和Akt抑制剂使GLUT4无法转运至细胞膜，造成脂肪和肌肉细胞中的葡萄糖摄取减少，引起短暂性胰岛素抵抗，肝脏糖原分解增加，导致高血糖和胰腺胰岛素代偿性分泌增加。胰岛素信号转导通路的失调也可能会重新激活PI3K信号转导，从而削弱PI3Kα抑制剂的疗效。血糖升高是PAM通路抑制剂的在靶效应，是药物起效的潜在标志，也是需要管理的信号，可以通过密切监测、剂量调整、生活方式改变以及降糖药物使用来进行综合管理。
2. 口腔炎：口腔黏膜是覆盖整个口腔并延伸至口咽部的特殊黏膜组织，药物的不良反应优先迅速影响口腔黏膜，从而导致口腔炎的发生。mTOR是调控细胞生长、增殖和代谢的关键蛋白。mTOR抑制剂会减少口腔上皮基底层细胞的正常更新和修复，导致黏膜屏障功能受损，从而引发口腔炎。mTOR抑制剂可通过调节免疫细胞的功能，影响口腔黏膜的免疫微环境，参与炎症反应的调控，导致黏膜对微生物或机械刺激的敏感性增加，从而诱发炎症和溃疡。mTOR抑制剂可减少黏膜血管的形成和修复，导致局部缺血和黏膜脆弱性增加，进一步促进溃疡的形成。
3. 皮疹：PI3K/Akt通路在维持表皮角质形成细胞的增殖和分化中起关键作用。PI3K抑制剂会导致角质形成细胞功能异常，表现为表皮增殖受阻、分化障碍及角质层完整性受损，这种屏障功能的破坏使皮肤更易受到外界刺激和微生物侵袭，进而引发皮疹。
4. 腹泻：PAM通路抑制剂相关腹泻的具体发生机制可能与Akt相关肠道上皮细胞完整性受损、电解质分泌和吸收异常、炎症因子的释放及肠上皮细胞增殖和修复障碍相关。Akt是一种丝氨酸-苏氨酸激酶，包括Akt1、Akt2和Akt3亚型，各亚型可通过磷酸化特定底物，对细胞的多种功能进行调节。Akt通过调控紧密连接蛋白的表达和分布，维持肠道上皮细胞的完整性。Akt抑制剂一方面会减少紧密连接蛋白的合成，导致肠道通透性增加，引起渗透性腹泻；另一方面可能影响氯离子、钠离子的分泌和吸收，导致肠腔内水分积聚，引起分泌性腹泻。Akt抑制剂还可以增强核转录因子κB的活性，促进肿瘤坏死因子α、白细胞介素6和白细胞介素1β等炎症因子的释放，引发肠道炎症。此外，Akt通过激活mTOR促进肠上皮细胞增殖和修复，而Akt抑制剂可延缓黏膜损伤的修复，加剧腹泻。
5. 血液学不良反应：PAM抑制剂通过阻断信号传导、阻滞细胞周期，进而抑制肿瘤细胞的增殖与存活。然而，该机制在抑制癌细胞的同时，也会影响正常细胞的更新，因此治疗期间极易引发骨髓抑制，导致血细胞生成减少。此外，Takafumi等的研究表明PI3K/Akt信号通路在血小板生成素诱导的巨核细胞增殖中扮演重要作用，这从另一角度解释了该类药物可能导致血小板减少的原因。
6. 肝损伤：PI3K对于肝细胞的存活至关重要，肝再生是肝损伤或肝部分切除术后的代偿过程，这个过程需要激活PI3K/Akt。相关研究表明，PI3K/Akt通路的抑制显著影响肝部分切除术后的肝脏再生过程。目前，PI3K抑制剂导致肝损伤的具体机制尚不明确，可能通过抑制糖酵解、诱导肝细胞凋亡等途径导致肝损伤。
7. 非感染性肺炎：PAM通路抑制剂引起的非感染性肺炎主要与mTOR抑制剂有关，但具体机制尚不明确。由于mTOR在调节免疫系统中的关键作用，免疫损伤可能是潜在机制之一。相关研究发现mTOR信号通路的抑制因子Rtp801可能引起肺炎。
三
PAM通路抑制剂不良反应的表现、监测、管理和建议
在本共识中，将PAM通路抑制剂不良反应分为常见不良反应和其他不良反应两类。常见不良反应主要为高血糖、口腔炎、皮疹及腹泻，其他不良反应主要为血液学不良反应、肝损伤及非感染性肺炎等。各PAM通路抑制剂不良反应谱不同，具体不良反应应参照药品说明书进行监测管理。参照不良事件通用术语评价标准4.03，目前已获得乳腺癌适应证的PAM通路抑制剂不良反应分级标准见表3。
（一）常见不良反应
1. 高血糖及相关并发症
（1）临床特点：抗肿瘤靶向药物引起的高血糖在症状方面并无特殊，仍具有“三多一少”的典型症状，即多饮、多食、多尿和体重减轻。如血糖过高还可能出现极度口渴、视力模糊、精神错乱、呼吸困难等症状。相较于mTOR/Akt抑制剂，PI3K抑制剂更易引发高血糖，发生时间为用药后7～15 d，通常是可逆的。PAM通路抑制剂导致的高血糖多为1～2级，经及时干预和管理，大部分患者可恢复。
（2）监测管理：接受治疗前，患者须充分了解高血糖症相关症状（如烦渴、多尿、视物模糊、疲倦、体重下降等），并接受相关教育（如同步进行生活方式干预，进行饮食结构及运动方式的调整）。此外，患者须充分了解可能诱发高血糖及相关急性并发症的风险因素（如既往糖尿病或糖尿病前期病史、肥胖、高龄、感染、应激状态、口服类固醇激素治疗等）和发生急性并发症时可能的伴随症状（如明显烦渴多饮、反复恶心呕吐、腹痛、意识障碍甚至昏迷）。需告知患者，出现上述急性并发症症状时应立即就医。
在启动PI3K抑制剂治疗前，明确患者是否存在治疗相关高血糖发生风险的危险因素至关重要。多项临床研究及专家共识指出，使用PI3K抑制剂新发糖尿病的关键危险因素包括高龄（年龄≥45岁）、肥胖（体质指数≥30 kg/m²）、糖尿病前期状态及糖尿病，其他危险因素还包括种族为亚裔或非裔美国人、单核细胞增多、糖尿病家族史、心血管疾病、高血压、多囊卵巢、妊娠糖尿病、高密度脂蛋白胆固醇＜0.9 mmol/L、甘油三酯＞2.82 mmol/L。
建议在PAM通路抑制剂治疗前完善FPG、PPG和HbA1c检查，必要时行葡萄糖耐量试验，以了解患者的基线血糖状况。建议对不同高血糖风险的患者采用不同的频率监测FPG和PPG。对于高风险患者需每天监测，对于中风险患者每周监测2次，对于不符合上述高、中风险标准的患者按照不同药物说明书及临床需要进行监测。对于使用伊那利塞的患者，建议第1周每3 d监测1次，后续3周每周监测1次，后续8周每2周监测1次，然后根据临床特征每4周监测1次。使用卡匹色替治疗后出现高血糖的患者，应至少每周监测2次，在使用抗糖尿病药物治疗期间，应至少每周监测1次，持续2个月，然后每2周监测1次，或按临床需要进行监测。对于使用依维莫司的非糖尿病患者，需每年监测1次。对于使用依维莫司的糖尿病患者，应根据临床需要监测。使用PAM通路抑制剂治疗期间，需每3个月监测1次HbA1c。建议在治疗前和治疗期间定期检测肾功能，以指导PAM通路抑制剂剂量调整及降糖药物选择。
对于存在高血糖风险的患者，既往的探索性研究表明，PI3K抑制剂治疗前予二甲双胍预防性降糖并配合饮食方式改变可降低各级高血糖发生率，但具体临床实践需根据症状和内分泌科建议谨慎预防性用药，并密切监测血糖和血酮体水平。因此，建议对高血糖高风险患者使用PAM通路抑制剂治疗前咨询内分泌科医师，共同评估PAM通路抑制剂的获益及风险。已确诊高血糖的患者，其临床管理严格按照分级处理启用降糖药物。目前，二甲双胍是治疗PAM通路抑制剂相关高血糖的首选药物，可在一定程度上增强胰岛素敏感性，二线或三线可考虑优先选用钠-葡萄糖协同转运蛋白2抑制剂、噻唑烷二酮等药物。在血糖明显升高存在酮症酸中毒风险时，可能需要使用胰岛素，建议血糖得到控制后尝试减量或停用。需要注意，停用PAM通路抑制剂后胰岛素敏感性可能迅速恢复，临床上需要及时减量或停用胰岛素以减少引起低血糖的风险。建议将血糖控制在≤8.9 mmol/L，临床还需根据患者情况制定个体化血糖管理目标，同时也建议医师为患者提供生活方式建议。通常1级高血糖无需调整PAM通路抑制剂剂量；≥2级时，严格按照各药物说明书进行剂量调整并及时进行降糖干预。具体分级处理策略见图1。
2. 口腔炎
（1）临床特点：口腔炎常出现于用药后的2～8周，临床常表现为明显的卵圆形溃疡，小而灰白，周围有红斑环，类似口疮性溃疡。一般情况下，口腔炎可能只引起轻微不适，严重情况下会导致疼痛和进食困难，反复发作会导致营养不良和体重下降。接受依维莫司和伊那利塞治疗的患者口腔炎的总体发生率分别为56%和55.3%，其中≥3级口腔炎的发生率为8%和5.6%，其中伊那利塞因口腔炎所致停药率为0.6%。通常经过积极的预防性治疗以及局部用药，可以有效控制口腔炎的发生。尽管大部分mTOR抑制剂相关口腔炎通过积极干预可以得到有效控制，但其仍会显著影响患者的生活质量与治疗依从性。
（2）监测管理：建议治疗前及治疗后第2、4和8周进行临床监测和口腔评估，利于早期识别治疗相关口腔炎并及时进行干预，患者在治疗期间出现口腔不适或影响进食饮水时应立刻复查。对于轻度口腔炎，指导患者避免使用含有酒精和过氧化氢衍生物的药物，并予营养支持；对于重度口腔炎，可使用局部麻醉剂、糖皮质激素、生长因子等，如用益普舒等黏膜保护剂或相应药物配制的漱口水（配比建议为0.9%氯化钠生理盐水50～100 ml+10 mg地塞米松磷酸钠注射液+0.2 g盐酸利多卡因注射液±抗生素）漱口，或考虑全身用药，包括抗生素、抗真菌药、抗病毒药、止痛药或其他适当的药物。建议患者在治疗期间定期到口腔科进行口腔清洁护理，保持良好口腔卫生习惯，避免进食刺激性食物。1级口腔炎无需调整剂量；2～3级时，应暂停用药并加强口腔护理，必要时请口腔科会诊，待恢复至≤1级后以相同剂量或降低1个剂量水平恢复治疗；4级时考虑永久停药。口腔炎的具体分级处理策略见图2。
3. 皮疹
（1）临床特点：皮疹是最常见的皮肤不良反应，常出现在用药后的1～2周，常表现为皮肤上出现红色或粉红色的扁平丘疹，散在分布或融合成片，伴随红肿、瘙痒等症状，多见于上肢和颈部，严重时可表现为脓疱。接受卡匹色替治疗的患者中，皮疹的总体发生率为38%，≥3级皮疹的发生率为12%，因皮疹所致停药率为7%。接受伊那利塞治疗的患者中，皮疹的总体发生率为26.7%，且未观察到≥3级皮疹的发生。大多数由PAM通路抑制剂引起的皮疹，通过适当的治疗或停止治疗可恢复。
（2）监测管理：应密切监测皮疹状态，建议患者避免强烈阳光照射，使用温和的沐浴皂、洗衣液、润肤剂和防晒霜，避免接触含有酒精、水杨酸等的刺激性产品。皮疹处可外用抗生素软膏，直至皮疹消退，抗生素推荐用硫酸新霉素、克林霉素、甲硝唑等。若伴有瘙痒可应用抗组胺药物，必要时口服抗生素治疗，如多西环素、米诺环素等，或进行局部或全身性皮质类固醇治疗。1级皮疹无需调整剂量，可局部使用糖皮质激素；2～3级时，暂停用药并请皮肤科会诊，待恢复至1级后以相同剂量或降低1个剂量水平恢复治疗；4级时永久停药。皮疹的具体分级处理策略见图3。
4. 腹泻
（1）临床特点：腹泻是使用PAM通路抑制剂常见的不良反应之一，尤其常见于初治患者，多表现为大便次数增多、大便失禁、造瘘口排出物增加等。卡匹色替引起的腹泻通常发生在治疗早期，患者首次出现腹泻的中位时间是8 d，各级腹泻发生率为77%，通常为1～2级，≥3级的发生率较低，临床上较容易处理，因腹泻所致停药率为2%。其他PAM通路抑制剂所致腹泻发生率在30%～60%之间，多数腹泻事件为1～2级，经一定治疗后可缓解恢复。
（2）监测管理：建议尽量避免空腹服用卡匹色替，同时进行饮食调整，避免摄入辛辣刺激的食物和饮料。如果采取上述方式不能缓解，应根据临床评估采取适当的措施，例如减少剂量、暂停用药或终止治疗，并进行止泻治疗。对于复发性腹泻患者，可考虑使用洛哌丁胺进行二级预防。洛哌丁胺是治疗腹泻的首选止泻药，推荐的初始剂量为4 mg，之后每次不成形便后再给予2 mg。对于重度腹泻或重度脱水，应考虑早期开始静脉补液。1级腹泻无需调整剂量，并预防性使用止泻药；2～3级时，应暂停用药，待恢复至≤1级后以相同剂量或降低1个剂量水平恢复治疗；4级时永久停药。腹泻的分级标准及相应的治疗措施见图4。
（二）其他不良反应
1. 血液学不良反应
（1）临床特点：血液学不良反应是PAM通路抑制剂的不良反应之一，常见血液学不良反应包括中性粒细胞减少症、血小板减少症、淋巴细胞减少症等，临床可能出现贫血、出血、发热、咳嗽、咽痛等症状。血液学不良反应发生频率较低，绝大多数可以在减少剂量、暂停用药或终止治疗后恢复。
（2）监测管理：治疗前需进行血常规检查，频率为2周1次。治疗期间每个周期的第1天和第15天监测血常规，有临床指征时增加监测频次。一般在用药初期监测较为频繁，后续根据病情稳定情况适当调整，临床上及时采取对症治疗。对于血液学不良反应，不同PAM通路抑制剂剂量调整方案不同，具体需参考说明书进行调整。以依维莫司为例，若出现≤2级中性粒细胞减少症，无需调整剂量；若出现3级中性粒细胞减少症伴发热或者4级中性粒细胞减少症，需要立刻停药，待恢复至≤2级后，可降低1个剂量水平恢复治疗。G-CSF可应用于中性粒细胞减少症的1级和2级预防，对于未预防性使用G-CSF且伴有并发感染风险因素的患者，可考虑治疗性使用G-CSF，并请血液科会诊制定个体化方案。
2. 肝损伤
（1）临床特点：肝损伤是与PI3K抑制剂相关的常见不良反应，表现为丙氨酸氨基转移酶（alanine transaminase， ALT）和天冬氨酸氨基转移酶（aspartate aminotransferase， AST）升高、胆红素实验室指标升高等。接受伊那利塞和依维莫司治疗的患者中，ALT升高的总体发生率分别为34%和51%，≥3级ALT升高的发生率分别为3.1%和4%。
（2）监测管理：目前尚无在中、重度肝功能不全患者中使用PAM通路抑制剂的经验，临床需谨慎使用。使用依维莫司前需检测转氨酶和胆红素水平，评估基线肝功能。应加强用药后患者肝功能的监测，及时发现肝损害的症状与肝功能指标异常，根据肝损害程度采取对症治疗、药物减量或停药等处理措施。建议前3个月每2周检测1次，随后3个月每1周检测1次，此后每1～3个月检测1次，有临床指征时增加监测频次。在治疗过程中，建议定期进行肝脏及胆道的CT或MRI检查。肝损伤的常规治疗可给予保肝、退黄等药物，急性肝功能衰竭成人患者可选用N-乙酰半胱氨酸，必要时可使用糖皮质激素。对合并乙肝的患者，使用依维莫司有导致乙肝激活的风险，需要定期检测乙肝DNA拷贝数，或预防使用抗乙肝病毒药物。1级ALT升高无需剂量调整；出现2～3级ALT升高时，应暂停用药并给予保肝治疗，恢复至1级后可谨慎减量继续治疗；4级或持续ALT升高时，建议永久停药，并进行活检明确病理类型。
3. 非感染性肺炎
（1）临床特点：非感染性肺炎的常见临床症状为咳嗽、咳痰等呼吸系统症状，部分患者可能出现呼吸困难或发热等症状，并有符合临床指征的影像学表现。非感染性肺炎是一种非靶向不良反应，不能完全避免。依维莫司治疗的患者中，19%发生非感染性肺炎，但并无致死风险，且肺炎的发生与药物疗效相关。大多数患者在停止依维莫司治疗后肺部症状消失，且与未发生依维莫司相关肺炎的患者相比，发生依维莫司相关肺炎患者的生存获益更长。
（2）监测管理：建议在使用PAM通路抑制剂之前询问患者肺部相关病史，患者若有任何呼吸系统症状或发烧等应及时告知医护人员，根据临床指征尽早行胸部薄层CT等检查排除感染。1级非感染性肺炎无需剂量调整；2～3级时，需暂停用药，并考虑皮质类固醇治疗，待恢复至≤1级后降低1个剂量水平恢复治疗，若4周内未恢复则终止治疗；4级时，永久停药，并听取呼吸科专家的建议。
四
药师在PAM通路抑制剂管理中的核心作用
在PAM信号通路抑制剂的使用过程中，药师是确保患者用药持续性与安全性的关键角色。其发挥的主要作用包括：（1）用药前指导：讲解PAM信号通路抑制剂的用法用量、潜在不良反应、生活注意事项等；（2）药物相关问题识别与处理：主动识别不良事件，对不良事件做基本分级对症处理，并为医师提供用药优化建议；（3）定期随访与监测：确认服药情况，监测相关指标，评估疗效，提供心理支持等；（4）协调医疗资源：出现严重不良反应时，建议患者联系主诊医师，协助进行PAM抑制剂剂量调整或申请会诊。
五
PAM通路抑制剂剂量方案与通用调整策略
已批准的PAM通路抑制剂推荐起始剂量以及减量梯度见表4。各PAM通路抑制剂因不良反应进行剂量调整的通用策略如下。
1. 伊那利塞：对于常见非血液学不良反应，1级时无需调整剂量；2～3级时，暂停治疗，直至恢复至1级后以相同剂量水平或降低1个剂量水平恢复治疗；4级时需永久停药。对于血液学不良反应，≤3级时无需调整剂量，4级时需暂停治疗，直至恢复至≤2级后再按照相同剂量水平或降低1个剂量水平恢复治疗。
2. 卡匹色替：对于常见不良反应，1级不良反应无需调整剂量；2～3级时，需暂停治疗直至恢复至1级，若在28 d内恢复至1级则按照相同剂量水平，若超过28 d则降低1个剂量水平恢复治疗；4级时需永久停药。
3. 依维莫司：对于血液学不良反应，例如中性粒细胞减少症，≤2级时无需调整剂量，3～4级时暂停治疗，直至恢复至≤2级后再以相同剂量或减半剂量水平恢复治疗。对于常见非血液学不良反应，1级无需调整剂量；2～3级时，需暂停治疗，直至恢复至1级后再以相同剂量或减半剂量水平恢复治疗；若出现3级不良反应复发或4级不良反应需永久停药。当剂量低于最低可用剂量时，可考虑隔日给药1次，之后再考虑终止治疗。
以上为当前已批准PAM通路抑制剂剂量调整的大致原则，临床实践中请务必遵照各药物的最新版本说明书进行剂量调整。
六
小结
PAM通路抑制剂为乳腺癌治疗提供了重要选择，目前10余种PAM通路抑制剂已进入乳腺癌治疗的临床试验阶段。PAM通路抑制剂总体安全性和耐受性良好，但也存在可以预测的不良反应，需根据药物靶点和患者特征进行个体化管理。具有共性的不良反应，例如高血糖、口腔炎、皮疹和腹泻需特别关注，而血液学不良反应、肝损伤和非感染性肺炎等也不容忽视。通过早期监测、分级干预和多学科协作，可进一步优化治疗安全性。临床医师应熟悉不同PAM通路抑制剂的安全性及其不良反应管理措施，遵循剂量调整原则，以平衡疗效与风险，改善乳腺癌患者的生存质量。
参考文献略。
纸质版期刊订阅：中国邮政网上营业厅（https://11185.cn/）检索“中华肿瘤杂志”在出版前订购；或中华医学期刊网-期刊服务-期刊商城订购过刊。
责任编辑 | 王书亚
审核发布 | 苏在明
终审 | 代小秋
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专家组组长
徐兵河（国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院药物临床试验研究中心）
专家组副组长
殷咏梅（南京医科大学第一附属医院 江苏省人民医院肿瘤科）
专家组成员（按姓氏汉语拼音字母排序）
蔡莉（哈尔滨医科大学附属肿瘤医院乳腺内科）
陈文艳（南昌市人民医院乳腺内科）
陈小松（上海交通大学医学院附属瑞金医院乳腺中心）
陈益定（浙江大学医学院附属第二医院乳腺外科）
崔岱（南京医科大学第一附属医院 江苏省人民医院内分泌科）
傅佩芬（浙江大学医学院附属第一医院乳腺外科）
甘露（重庆医科大学第一附属医院乳腺内科）
耿翠芝（河北医科大学第四医院乳腺中心）
郭雯晖（福建医科大学附属协和医院乳腺外科）
贺飞（国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院药剂科）
洪澍彬（中山大学附属第一医院内分泌科）
李慧慧（山东省肿瘤医院乳腺内科）
李曼（大连医科大学附属第二医院肿瘤内科）
梁艳（南京医科大学第一附属医院 江苏省人民医院肿瘤科）
林吴芬（浙江益药全德堂药房）
刘潇衍（中国医学科学院北京协和医院呼吸内科）
罗婷（四川大学华西医院乳腺疾病中心）
吕铮（吉林大学第一医院肿瘤内科）
马力（河北医科大学第四医院肿瘤内科）
潘跃银（中国科学技术大学附属第一医院肿瘤内科）
史业辉（天津市肿瘤医院乳腺肿瘤内科）
宋彬（山西白求恩医院肿瘤内科）
宋传贵（福建省肿瘤医院乳腺外科）
宋国红（北京大学肿瘤医院乳腺肿瘤内科）
孙涛（辽宁省肿瘤医院乳腺内科）
王佳玉（国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院内科）
王墨培（北京大学第三医院肿瘤内科）
王守满（中南大学湘雅医院乳腺科）
王娴（浙江大学医学院附属邵逸夫医院肿瘤内科）
王晓稼（浙江省肿瘤医院乳腺内科）
王原（河北医科大学第四医院内分泌科）
吴依芬（东莞市人民医院乳腺肿瘤科）
熊慧华（华中科技大学附属同济医院肿瘤科）
徐兵河（国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院药物临床试验研究中心）
闫敏（河南省肿瘤医院乳腺中心）
杨翠翠（北京圆心大药房）
杨谨（西安交通大学第一附属医院肿瘤内科）
易文君（中南大学湘雅二医院乳腺外科）
殷咏梅（南京医科大学第一附属医院 江苏省人民医院肿瘤科）
袁渊（江苏省肿瘤医院肿瘤内科）
曾银朵（中山大学孙逸仙纪念医院乳腺内科）
张化冰（中国医学科学院北京协和医院内分泌科）
赵兵（新疆医科大学附属肿瘤医院肿瘤内科）
赵艳霞（华中科技大学附属协和医院乳腺肿瘤科）
郑红梅（湖北省肿瘤医院乳腺中心）
周嘉强（浙江大学医学院附属邵逸夫医院内分泌科）
周易冬（中国医学科学院北京协和医院乳腺外科）
朱昕雨（江苏省医药有限公司大药房）
执笔人
王佳玉（国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院内科）梁艳（南京医科大学第一附属医院 江苏省人民医院肿瘤科）
（来源：中华肿瘤杂志）
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阅读原文：#乳腺肿瘤# 合集
上市批准临床1期临床结果CSCO会议引进/卖出
2026-02-26
Clinical Infectious Diseases Volume 82 Issue 1
临床传染病学 82卷1期
https://academic.oup.com/cid/issue/
ID Art Through the Ages（穿越时代的传染病学技艺）
1
Peasants' Revolt, 1381
1381年农民起义
Mary Grizzard and Michael Grizzard
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Page i, https://doi.org/10.1093/cid/ciaf692
In the Literature（文献概览）
2
In the Literature
文献概览
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages ii–iii, https://doi.org/10.1093/cid/ciaf631
State-of-the-Art Review（最新技术综述）
3
State-of-the-Art Review: Diagnosis and Management of Acute and Chronic Bacterial Prostatitis
最新技术综述：急性和慢性细菌性前列腺炎的诊断与治疗
Prathit A Kulkarni and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 1–13, https://doi.org/10.1093/cid/ciaf483
Clinical Dilemmas in Infectious Diseases（传染病临床难题）
4
“Insisting on Treatment”
“坚持治疗”
Kevin Andrew Smith and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 14–18, https://doi.org/10.1093/cid/ciaf282
Voices of ID（传染病之声）
5
Martin Arrowsmith and Me
马丁·阿罗史密斯与我
Janet R Gilsdorf
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 19–20, https://doi.org/10.1093/cid/ciaf277
Invited Commentary（特邀述评）
6
The 2025 Centers for Disease Control and Prevention Nonoccupational HIV Postexposure Prophylaxis Guidelines: Updated Regimens and Remaining Questions
2025年美国疾病控制与预防中心非职业性艾滋病毒暴露后预防指南：更新方案及遗留问题
Lao-Tzu Allan-Blitz and Kenneth H Mayer
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 21–24, https://doi.org/10.1093/cid/ciaf567
Antimicrobial Resistance and Stewardship（抗菌药物耐药性与管控）
7
Modeling the Impact and Cost of a Culture-Dependent Molecular Test for Antimicrobial Resistance in Resource-Limited Settings
资源有限环境下，基于培养的分子检测法对抗菌药物耐药性的影响和成本建模
Joshua M Chevalier and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 25–32, https://doi.org/10.1093/cid/ciaf236
8
The Xpert MTB/RIF Cycle Threshold Value Predicts Mycobacterium tuberculosis Transmission to Close Contacts in a Brazilian Prospective Multicenter Cohort
巴西一项前瞻性多中心队列研究中Xpert MTB/RIF循环阈值可预测结核分枝杆菌在密切接触者中的传播
Leandro S Garcia and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 33–41, https://doi.org/10.1093/cid/ciad794
9
Beyond Diagnosis: Xpert Cycle Threshold Values as Predictors of Tuberculosis Transmission
超越诊断：Xpert循环阈值作为结核病传播的预测指标
Lauren Linde and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 42–43, https://doi.org/10.1093/cid/ciad791
10
First Report of Treatment-Emergent Resistance to Cefepime-Zidebactam in Pseudomonas aeruginosa
铜绿假单胞菌在头孢吡肟-齐德巴坦治疗中出现耐药性的首例报告
Ava J Dorazio and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 44–48, https://doi.org/10.1093/cid/ciaf638
Clinical Practice and Policy（临床实践与政策）
11
Sputum and Tongue Swab Molecular Testing for the In-Home Diagnosis of Tuberculosis in Unselected Household Contacts: A Cost and Cost-Effectiveness Analysis
痰液和舌拭子分子检测用于未筛选家庭接触者结核病居家诊断的成本及成本效益分析
Charl Bezuidenhout and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 49–57, https://doi.org/10.1093/cid/ciaf389
12
You’ve Got a Friend in Me: Curbside Questions Infectious Diseases Clinicians Ask Infectious Diseases Pharmacists
我是你的朋友：传染病临床医生向传染病药剂师咨询的即兴问题
Matthew R Davis and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 58–61, https://doi.org/10.1093/cid/ciaf250
13
Home Testing for Contagious Illness: Historical Context and Modern Caveats
传染性疾病居家检测：历史背景与现代注意事项
Abigail Zuger
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 62–66, https://doi.org/10.1093/cid/ciaf623
Fungal Infections（真菌感染）
14
Evaluating the Use of Lower Dose Flucytosine for the Treatment of Cryptococcal Meningitis: A Clinical Trial
评估低剂量氟胞嘧啶治疗隐球菌性脑膜炎的临床试验
Morris K Rutakingirwa and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 67–74, https://doi.org/10.1093/cid/ciaf432
15
Association Between Duration of Candidemia and Clinical and Healthcare Resource Utilization Outcomes Among Hospitalized Adult Patients With Candidemia Who Received Empiric Treatment With an Echinocandin Across United States Hospitals
美国各医院中接受棘白菌素经验性治疗的念珠菌血症成年住院患者中，念珠菌血症持续时间与临床和医疗资源利用结局之间的关联
Thomas P Lodise and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 75–85, https://doi.org/10.1093/cid/ciaf472
16
Aspergillosis-Attributable Mortality in the United States: Analysis of Death Certificate Data
美国隐球菌病导致的死亡率分析：基于死亡证明数据
Thomas J Walsh and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 86–92, https://doi.org/10.1093/cid/ciaf653
HIV/AIDs（人类免疫缺陷病毒/艾滋病）
17
Outcomes of Critical Illness in People With Advanced HIV Disease: 30 Years of Binational Data
晚期艾滋病患者危重症结局：30年的双国数据
Bryan Tan and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 93–99, https://doi.org/10.1093/cid/ciaf362
18
Phase 2 Trial of Long-Acting Cabotegravir and VRC07-523LS for Viral Suppression in Adults With HIV-1: ACTG A5357
长效卡博特韦和VRC07-523LS用于HIV-1感染成人病毒抑制的2期试验：ACTG A5357
Babafemi O Taiwo and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 100–108, https://doi.org/10.1093/cid/ciaf375
19
Therapeutic Drug Monitoring of Long-Acting Cabotegravir and Rilpivirine in a National Cohort of People With HIV-1: First Results From the ANRS-MIE CARLAPOP Study
全国HIV-1感染者队列中长效卡博特韦和利匹韦林的治疗药物监测：ANRS-MIE CARLAPOP研究的首批结果
Nadège Néant and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 109–118, https://doi.org/10.1093/cid/ciaf385
20
Is Therapeutic Drug Monitoring of Long-Acting Cabotegravir and Rilpivirine of Clinical Utility?
长效卡博特韦和利匹韦林的治疗药物监测是否具有临床实用性？
Catia Marzolini
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 119–121, https://doi.org/10.1093/cid/ciaf386
21
Efficacy and Safety of Dual Therapy With Dolutegravir/Lamivudine in Treatment-naive Persons With CD4 Counts <200/mm3: 48-Week Results of the DOLCE Study
多替拉韦/拉米夫定双药治疗在CD4计数<200/mm³的初治患者中的疗效和安全性：DOLCE研究48周结果
Maria Ines Figueroa and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 122–131, https://doi.org/10.1093/cid/ciaf415
22
DOLCE: Sweet Success for Dolutegravir/Lamivudine?
DOLCE研究：多替拉韦/拉米夫定双药治疗是否取得完美成功？
Laura J Waters
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 132–133, https://doi.org/10.1093/cid/ciaf416
Infection Control and Hospital Epidemiology（感染控制与医院流行病学）
23
Real-Time Genomic Surveillance for Enhanced Healthcare Outbreak Detection and Control: Clinical and Economic Impact
实时基因组监测用于加强医疗保健机构疫情检测与控制：临床与经济影响
Alexander J Sundermann and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 134–141, https://doi.org/10.1093/cid/ciaf216
24
Patient Perspectives Regarding Different Contact Precaution Policies for Methicillin-resistant Staphylococcus aureus Across Two Hospitals: Patients Are in Favor of Contact Precautions
两家医院患者对耐甲氧西林金黄色葡萄球菌不同接触预防政策的态度：患者支持接触预防措施
Nicholas F Angelino and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 142–144, https://doi.org/10.1093/cid/ciaf330
Photo Quiz（影像问答）
25
The Clue That Wriggled into View
蜿蜒入目的线索
Nitin Gupta and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 145–147, https://doi.org/10.1093/cid/ciaf427
Infection Control and Hospital Epidemiology（感染控制与医院流行病学）
26
Comparing Generative Artificial Intelligence vs Experts for Detection of Catheter-Associated Urinary Tract Infection
比较生成式人工智能与专家在导管相关尿路感染检测中的应用
Shatha Alshanqeeti and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 148–150, https://doi.org/10.1093/cid/ciaf486
Sexually Transmitted Infections（性传播感染）
27
Viability of Chlamydia trachomatis in Different Anatomical Sites—a Systematic Review and Meta-analysis
不同解剖部位沙眼衣原体的存活能力——系统综述和荟萃分析
Arthur Wong and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 151–158, https://doi.org/10.1093/cid/ciae401
Photo Quiz（影像问答）
28
A 46-Year-Old With Persistent Altered Mental Status and Respiratory Failure
一例46岁患者持续出现意识状态改变伴呼吸衰竭
Ann F Yang and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 159–161, https://doi.org/10.1093/cid/ciaf439
Sexually Transmitted Infections（性传播感染）
29
Mpox in People With HIV: Predictors of Diagnosis, Outcomes, and Vaccine Effectiveness in a Multisite Cohort
HIV感染者中的猴痘：多站点队列中诊断、预后和疫苗有效性的预测因素
Michalina Montaño and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 162–172, https://doi.org/10.1093/cid/ciae464
30
Development and Evaluation of a Novel Algorithm to Identify Doxycycline Postexposure Prophylaxis Users at a Large Healthcare System in the Bronx, New York
开发和评估一种新型算法，用于识别纽约布朗克斯区一家大型医疗系统中多西环素暴露后预防用药者
Caroline E Mullis and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 173–176, https://doi.org/10.1093/cid/ciaf109
31
Evidence-Informed Provision of Doxycycline Postexposure Prophylaxis for Prevention of Bacterial Sexually Transmitted Infections
为预防细菌性性传播感染提供基于证据的多西环素暴露后预防用药
Julia C Dombrowski and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 177–184, https://doi.org/10.1093/cid/ciae527
Bacterial Infections（细菌性感染）
32
Long-term Mortality Trends Among Individuals With Tuberculosis: A Retrospective Cohort Study of Individuals Diagnosed With Tuberculosis in Brazil
巴西结核病患者的长期死亡率趋势：一项针对巴西结核病诊断患者的回顾性队列研究
Sun Kim and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e1–e8, https://doi.org/10.1093/cid/ciaf206
33
Clinical and Microbiological Characteristics of Meningococcal Eye Infections: Retrospective National Surveillance in England, 2010–2022
脑膜炎球菌眼部感染的临床和微生物学特征：2010 - 2022年英格兰全国回顾性监测
Stephen A Clark and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e9–e16, https://doi.org/10.1093/cid/ciaf274
34
Does Piperacillin-Tazobactam Increase Mortality Risk Compared With Cefepime? Collider Bias and the Importance of Assumptions in Instrumental Variable Analyses
与头孢吡肟相比，哌拉西林-他唑巴坦是否会增加死亡率风险？工具变量分析中的混杂偏倚和假设的重要性
Fergus Hamilton and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e17–e23, https://doi.org/10.1093/cid/ciaf317
COVID-19 / SARS COV-2（新冠肺炎/严重急性呼吸综合征冠状病毒2型）
35
Efficacy and Safety of Obeldesivir in High-Risk Nonhospitalized Patients With COVID-19 (BIRCH): A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study
奥贝德西韦在高危非住院COVID-19患者（BIRCH研究）中的疗效和安全性：一项3期、随机、双盲、安慰剂对照研究
Anca Streinu-Cercel and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e24–e32, https://doi.org/10.1093/cid/ciaf406
36
Retreatment With Nirmatrelvir/Ritonavir Following Return of COVID-19 Symptoms and SARS-CoV-2 Positivity
COVID-19症状复发且SARS-CoV-2检测呈阳性后使用奈玛特韦/利托那韦重新治疗
Wuyan Zhang and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e33–e40, https://doi.org/10.1093/cid/ciaf548
Emerging Infections(新兴感染)
37
“I Didn’t Know Him Before the Pandemic… Now He's on My Speed Dial”: Strengthening Collaboration Between Infectious Diseases Physicians and State and Local Public Health for Future Public Health Emergencies
“疫情前我并不认识他……现在他已是我的快速拨号对象”：加强传染病医生与州和地方公共卫生部门在未来突发公共卫生事件中的合作
Diana Valencia and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e41–e46, https://doi.org/10.1093/cid/ciaf179
38
Identification of and Response to Influenza A(H5) in Off-the-Shelf Raw Milk—Santa Clara County, California, November–December 2024
2024年11 - 12月加利福尼亚州圣克拉拉县在现成生牛奶中检出甲型流感（H5）病毒及应对措施
Alessandra Løchen and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e47–e48, https://doi.org/10.1093/cid/ciaf420
39
The Indispensable Value of Small-Molecule Antivirals in Epidemic and Pandemic Preparedness
小分子抗病毒药物在流行病和大流行病防范中的不可或缺价值
Ruxandra Draghia-Akli and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e49–e55, https://doi.org/10.1093/cid/ciaf476
HIV/AIDs（人类免疫缺陷病毒/艾滋病）
40
Increasing HIV Testing During Gonorrhea and Chlamydia Evaluations in Urgent Care and Emergency Departments: A Large Health System Initiative
在紧急护理和急诊科进行淋病和衣原体检测时增加HIV检测：一项大型医疗系统倡议
Allan M Seibert and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e56–e67, https://doi.org/10.1093/cid/ciaf434
41
Clinical Predictors and Incidence of Kaposi Sarcoma Among Males With HIV in the Treat-All Era in the United States and Canada
美国和加拿大“全员治疗”时代男性HIV感染者卡波西肉瘤的临床预测因素和发病率
Sally B Coburn and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e68–e77, https://doi.org/10.1093/cid/ciaf446
42
Integrase Strand Transfer Inhibitors for Treatment-experienced Young Adults With Perinatal HIV in the US: Immunologic, Virologic, and Anthropometric Outcomes
美国接受过治疗的围产期感染HIV的年轻成人使用整合酶链转移抑制剂的免疫学、病毒学和人体测量学结果
Kunjal Patel and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e78–e88, https://doi.org/10.1093/cid/ciaf538
43
Win Ratio Aligns With and Enhances Interpretation of REPRIEVE's Primary Findings
Win比值与REPRIEVE研究的主要发现一致并增强了其解释性
Emma Davies Smith and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e89–e92, https://doi.org/10.1093/cid/ciaf477
44
The Critical Importance of Clinical Use Case to Inform Point-of-Care Technology Development: A Case Study of HIV Nucleic Acid Assays in the United States
临床应用案例对于指导即时检测技术开发的重要性：以美国HIV核酸检测为例
Yukari C Manabe and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e93–e99, https://doi.org/10.1093/cid/ciaf510
Mycobacterial Infections（分枝杆菌感染）
45
Body Mass Index and Incident Tuberculosis in Close Tuberculosis Contacts
结核密切接触者中体重指数与新发结核病的关系
María B Arriaga and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e100–e109, https://doi.org/10.1093/cid/ciaf475
46
The Role of Youths in Within-Household Tuberculosis Transmission: A Household Contact Cohort Study
青年在家庭内结核病传播中的作用：一项家庭接触队列研究
Meredith B Brooks and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e110–e118, https://doi.org/10.1093/cid/ciaf490
47
Cost-effectiveness of Targeted Next-Generation Sequencing for Tuberculosis Drug-resistance Testing as an Alternative to the Standard of Care in South Africa
南非以靶向下一代测序作为结核病耐药检测标准护理方案的替代方案的成本效益分析
Alexandra de Nooy and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e119–e125, https://doi.org/10.1093/cid/ciaf495
48
Xpert MTB/RIF Cycle Threshold as a Marker of Tuberculosis (TB) Disease Severity: Implications for TB Treatment Stratification
Xpert MTB/RIF循环阈值作为结核病（TB）疾病严重程度的标志物：对结核病治疗分层的启示
Daniel J Grint and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e126–e134, https://doi.org/10.1093/cid/ciaf527
49
The Role of β-Lactam Antibiotics in Treating Mycobacterium abscessus: From Laboratory Insights to Clinical Applications and the Case for Clinical Trials
β-内酰胺类抗生素在治疗脓肿分枝杆菌中的作用：从实验室见解到临床应用及开展临床试验的必要性
Khalid M Dousa and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e135–e145, https://doi.org/10.1093/cid/ciaf547
Pediatric and Maternal Infectious Diseases（儿科与孕产妇传染病）
50
Efficacy, Immunogenicity, and Safety of an Investigational Maternal Respiratory Syncytial Virus Prefusion F Protein–Based Vaccine
一种研究性孕产妇呼吸道合胞病毒融合前F蛋白疫苗的疗效、免疫原性和安全性
Peyman Banooni and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e146–e155, https://doi.org/10.1093/cid/ciaf033
51
Hepatotoxicity Among People With HIV and Receiving Isoniazid Preventive Therapy in Pregnancy and Postpartum: The Role of Antiretroviral Regimen and Pharmacogenetics
HIV感染者在孕期和产后接受异烟肼预防性治疗时的肝毒性：抗逆转录病毒治疗方案和药物基因组学的作用
Grace Montepiedra and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e156–e164, https://doi.org/10.1093/cid/ciaf198
52
Transplacental Transfer of Lumefantrine, Mefloquine, and Piperaquine: A Comparison of Concentrations in Mothers, Neonates, and Cord Blood
青蒿素、甲氟喹和哌喹的胎盘转运：母亲、新生儿和脐带血中浓度的比较
Makoto Saito and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e165–e173, https://doi.org/10.1093/cid/ciaf552
53
Why Did the Antimalarial Drug Cross the Placenta?
抗疟药为何要穿过胎盘？
Stephen J Rogerson and Holger W Unger
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e174–e175, https://doi.org/10.1093/cid/ciaf553
Viral Infections（病毒性传染病）
54
Kinetics and Predictors of Hepatitis B Surface Antigen Loss After Commencing Hepatitis B Virus (HBV)–Active Antiretroviral Therapy in the Setting of HIV and Chronic HBV Coinfection
HIV和慢性乙型肝炎病毒（HBV）共感染患者开始使用HBV活性抗逆转录病毒治疗后乙型肝炎表面抗原消失的动力学和预测因素
Jennifer Audsley and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e176–e184, https://doi.org/10.1093/cid/ciaf281
55
Secondary Pneumococcal Disease in Veterans With Viral Respiratory Infections
患有病毒性呼吸道感染退伍军人的继发性肺炎球菌病
Lauren A Powers and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e185–e190, https://doi.org/10.1093/cid/ciaf285
Correspondence（读者来信）
56
Unveiling Latent Risk Patterns in Antimicrobial-Resistant Bacteremia: A Deeper Look at Pathogen-Specific Mortality
揭示抗菌药物耐药性菌血症中的潜在风险模式：深入探究病原体特异性死亡率
Yuan-Ti Lee and Shiuan-Chih Chen
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Page e191, https://doi.org/10.1093/cid/ciaf493
57
Resistance to Antibiotics With High Empiric Treatment Relevance Explains Attributable Mortality Across 110 Pathogen-antibiotic Combinations
对经验性治疗具有高度相关性的抗生素耐药性可解释110种病原体 - 抗生素组合的归因死亡率
Kevin A Brown and Nick Daneman
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e191–e192, https://doi.org/10.1093/cid/ciaf494
58
Culture Clash: Dual-Pathogen Endocarditis and the Metagenomic Next-Generation Sequencing Studies We Need
文化冲突：双病原体心内膜炎以及我们所需的宏基因组下一代测序研究
Carl Boodman and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e193–e195, https://doi.org/10.1093/cid/ciaf518
59
Metagenomic Next-Generation Sequencing and Cardiovascular Infections: Promise and Pitfalls of Polymicrobial Detection
宏基因组下一代测序与心血管感染：多微生物检测的前景与陷阱
Sarwat Khalil and M Rizwan Sohail
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Page e196, https://doi.org/10.1093/cid/ciaf519
60
It Is Time to Go Beyond the Association Between Colistin and Meropenem for Invasive Carbapenem-Resistant Acinetobacter baumannii Infections
是时候超越多粘菌素和美罗培南联合治疗侵袭性碳青霉烯耐药鲍曼不动杆菌感染了
Alberto Enrico Maraolo and Giancarlo Ceccarelli
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e197–e198, https://doi.org/10.1093/cid/ciaf533
61
Actually, It May be Time to Return to Colistin and Meropenem in Some Patients Infected With Carbapenem-resistant Acinetobacter baumannii (CRAB)
实际上，对于某些感染碳青霉烯耐药鲍曼不动杆菌（CRAB）的患者，或许是时候重新使用多粘菌素和美罗培南了
Jason M Pogue and Keith S Kaye
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e198–e199, https://doi.org/10.1093/cid/ciaf534
62
COVID-19 and Bacterial Pneumonia: Protective Effect or Diagnostic Bias?
COVID-19和细菌性肺炎：保护作用还是诊断偏差？
Duygu Aydın and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Page e200, https://doi.org/10.1093/cid/ciaf539
63
Secondary Pneumococcal Disease in Veterans With Viral Respiratory Infections: A Follow Up
患有病毒性呼吸道感染退伍军人的继发性肺炎球菌病：后续研究
John C Hu and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e200–e201, https://doi.org/10.1093/cid/ciaf540
64
Long-Acting Cabotegravir/Rilpivirine in Viremic People With HIV: Bumpy Road to Perfection
长效卡博特韦/利匹韦林用于病毒载量阳性的HIV感染者：通往完美的坎坷之路
Beatrice Barda and Marco Bongiovanni
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e201–e202, https://doi.org/10.1093/cid/ciaf482
65
Beyond the Sequence: Operationalizing Whole-Genome Sequencing for Real-time Infection Control in Low- and Middle-Income-Country Healthcare Settings Healthcare Settings
超越序列：在中低收入国家医疗环境中实际应用全基因组测序进行实时感染控制
Schawanya Kaewpitoon Rattanapitoon and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e202–e203, https://doi.org/10.1093/cid/ciaf535
66
Reassessing Adherence Trajectories in Multidrug-Resistant Tuberculosis: Recovery Advantage and Hidden Biases
重新评估耐多药结核病的依从性轨迹：康复优势和隐藏偏差
Shiuan-Chih Chen and Chun-Chieh Chen
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e203–e204, https://doi.org/10.1093/cid/ciaf536
67
Metagenomic Sequencing of Blood Culture Broth for Diagnosing Fastidious Endocarditis
血培养肉汤宏基因组测序用于诊断苛养性心内膜炎
Po-Hsiu Huang and others
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e204–e205, https://doi.org/10.1093/cid/ciaf554
Corrections（更正）
68
Correction to: Secondary Pneumococcal Disease in Veterans With Viral Respiratory Infections
《患有病毒性呼吸道感染退伍军人的继发性肺炎球菌病》更正
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Page e206, https://doi.org/10.1093/cid/ciaf572
69
Correction to: Treatment Outcomes With an Oral Short Course Regimen for Rifampicin-resistant Tuberculosis in a High HIV Prevalence, Programmatic Setting in South Africa
《南非高HIV流行率、项目化环境中口服短程利福平耐药结核病治疗方案的治疗结果》更正
Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Page e207, https://doi.org/10.1093/cid/ciaf711
Clinical Infectious Diseases Volume 82 Issue Supplement_1
临床传染病学 82卷 增刊1期
https://academic.oup.com/cid/issue/82/Supplement_1
SUPPLEMENT（增刊）
Laboratory and Point-of-care Testing to Detect Chlamydia trachomatis and Neisseria gonorrhoeae: Review of the Available Evidence
实验室及即时检测技术用于检测沙眼衣原体和淋病奈瑟菌：现有证据综述
SUPPLEMENT ARTICLES（增刊论著）
1
Evidence Review for Centers for Disease Control and Prevention Guidance Development on the Detection of Chlamydia trachomatis and Neisseria gonorrhoeae
美国疾病控制与预防中心沙眼衣原体和淋病奈瑟菌检测指南制定证据综述
Amanda C Smith and Ellen N Kersh
Clinical Infectious Diseases, Volume 82, Issue Supplement_1, 15 February 2026, Pages S1–S5, https://doi.org/10.1093/cid/ciaf665
2
Narrative Review of Chlamydia trachomatis Culture, Viability Testing, and Sequencing Methods
沙眼衣原体培养、活性检测及测序方法的叙述性综述
Alana K Sterkel and others
Clinical Infectious Diseases, Volume 82, Issue Supplement_1, 15 February 2026, Pages S6–S12, https://doi.org/10.1093/cid/ciaf697
3
Culture and Identification of Neisseria gonorrhoeae: A Narrative Review of Current Laboratory Methods
淋病奈瑟菌培养与鉴定：当前实验室方法叙述性综述
Olusegun O Soge and others
Clinical Infectious Diseases, Volume 82, Issue Supplement_1, 15 February 2026, Pages S13–S18, https://doi.org/10.1093/cid/ciaf698
4
Review of the Performance of Laboratory-Based Molecular Diagnostics for Chlamydia trachomatis and Neisseria gonorrhoeae
实验室分子诊断技术检测沙眼衣原体和淋病奈瑟菌的性能综述
Megan Crumpler and others
Clinical Infectious Diseases, Volume 82, Issue Supplement_1, 15 February 2026, Pages S19–S35, https://doi.org/10.1093/cid/ciaf696
5
Review of Methods for Detecting Antimicrobial Resistance of Neisseria gonorrhoeae
淋病奈瑟菌抗菌药物耐药性检测方法综述
Kara K Mitchell and others
Clinical Infectious Diseases, Volume 82, Issue Supplement_1, 15 February 2026, Pages S36–S42, https://doi.org/10.1093/cid/ciaf706
6
Point-of-care Tests for Chlamydia trachomatis and Neisseria gonorrhoeae: Review of the Literature
沙眼衣原体和淋病奈瑟菌即时检测技术文献综述
Yukari C Manabe and others
Clinical Infectious Diseases, Volume 82, Issue Supplement_1, 15 February 2026, Pages S43–S51, https://doi.org/10.1093/cid/ciaf699
Clinical Infectious Diseases Volume 82 Issue 2
临床传染病学 82卷 2期
https://academic.oup.com/cid/issue/
ID Art Through the Ages（穿越时代的传染病技艺）
1
Interior of the Old Jersey Prison Ship in the Revolutionary War
美国革命战争中老泽西监狱船的内部景象
Mary Grizzard and Michael Grizzard
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Page i, https://doi.org/10.1093/cid/ciaf693
In the Literature（本期精选）
2
In the Literature
本期精选
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages ii–v, https://doi.org/10.1093/cid/ciag011
IDSA 2025 Collections Editorial（美国传染病学会2025年专题合集社论）
3
2025 Content Collections from the IDSA Journals
IDSA期刊2025年内容合集
Roger Bedimo and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 185–186, https://doi.org/10.1093/cid/ciag041
State-of-the-Art Review（前沿综述）
4
State-of-the-Art Review: Chagas Disease—an Enduring Challenge
前沿综述：恰加斯病——一个持续存在的挑战
Nelson Iván Agudelo Higuita and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 187–205, https://doi.org/10.1093/cid/ciaf654
IDSA Features（美国传染病学会特色内容）
5
Policy Recommendations to Support Equitable Access to Long-Acting Injectables for HIV Prevention and Treatment: A Policy Paper of the Infectious Diseases Society of America and the HIV Medicine Association
支持公平获取用于艾滋病毒预防和治疗的长效注射剂的政策建议：美国传染病学会与艾滋病毒医学协会的政策文件
Julia L Marcus and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 206–211, https://doi.org/10.1093/cid/ciae648
Voices of ID（传染病之声）
6
A “Terminal Infection”
“绝症感染”
Jennifer Furin
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 212–214, https://doi.org/10.1093/cid/ciaf332
Invited Commentary（特邀评论）
7
A Rapid Test to Differentiate Viral From Bacterial Infections: Searching for the Holy Grail
区分病毒与细菌感染的快速检测：寻找“圣杯”
Lao-Tzu Allan-Blitz and Jeffrey D Klausner
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 215–218, https://doi.org/10.1093/cid/ciaf585
Bacterial Infections（细菌感染）
8
Nonoperative Versus Neurosurgical Treatment of Brain Abscess: An Emulated Trial Nested Within a Nationwide, Population-Based Cohort
脑脓肿的非手术治疗与神经外科治疗：一项基于全国人群队列的模拟试验
Emilie Marie Eriksen and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 219–227, https://doi.org/10.1093/cid/ciaf304
9
What Is the Impact of Anti-Enterococcal Empirical Therapy on Survival of Patients With Enterococcal Bloodstream Infections?
抗肠球菌经验性治疗对肠球菌血流感染患者生存率的影响是什么？
Linda Bussini and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 228–237, https://doi.org/10.1093/cid/ciaf323
10
Adjunctive Fosfomycin for the Treatment of Staphylococcus aureus Bacteremia: A Pooled Post Hoc Analysis of Individual Participant Data From 2 Randomized Trials
辅助使用磷霉素治疗金黄色葡萄球菌菌血症：两项随机试验个体参与者数据的汇总事后分析
Francesc Escrihuela-Vidal and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 238–245, https://doi.org/10.1093/cid/ciaf387
HIV/AIDs（人类免疫缺陷病毒/艾滋病）
11
Kinetics of Non-nucleoside Reverse Transcriptase Inhibitor Resistance-associated Mutations in HIV-1 Proviral Cellular Reservoirs in Non-nucleoside Reverse Transcriptase Inhibitor-experienced Persons
在接受过非核苷类逆转录酶抑制剂治疗的HIV-1感染者中，非核苷类逆转录酶抑制剂耐药相关突变在HIV-1前病毒细胞储存库中的动力学
Thomas Drumel and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 246–251, https://doi.org/10.1093/cid/ciaf430
12
Impact of Different Integrase Strand Transfer Inhibitors on Body Mass Index Among People With HIV Who Newly Started Antiretroviral Therapy in Shenzhen, China: A Real-World Data Analysis
中国深圳新开始抗逆转录病毒治疗的HIV感染者使用不同整合酶链转移抑制剂对体重指数的影响：一项现实数据分析
Lukun Zhang and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 252–261, https://doi.org/10.1093/cid/ciaf466
13
Consequences of Stopping Antiretroviral Treatment in a Persistently Seronegative Individual with HIV-1
HIV-1持续血清阴性个体停止抗逆转录病毒治疗的后果
Marc Wirden and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 262–264, https://doi.org/10.1093/cid/ciaf422
14
Approaches to the Management of Virologic Failure on Dolutegravir-Based Antiretroviral Therapy in the 50 Countries With the Highest Adult HIV Prevalence
在成人HIV患病率最高的50个国家中，多替拉韦为基础的抗逆转录病毒治疗出现病毒学失败的治疗方法
Cameron T Nutt and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 265–273, https://doi.org/10.1093/cid/ciaf444
Mycobacterial Infections（结核分枝杆菌感染）
15
Retrospective Cohort Analysis for Identification of Discordant Rifampicin-resistant Xpert MTB/RIF Assay Results in South Kivu, Eastern Democratic Republic of the Congo, a High Burden Tuberculosis Setting
刚果民主共和国东部南基伍这一结核病高负荷地区，识别利福平耐药不一致的Xpert MTB/RIF检测结果的回顾性队列分析
Bertin C Bisimwa and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 274–281, https://doi.org/10.1093/cid/ciaf451
16
Prevention of Tuberculosis in Patients Treated With Biological Therapies: 20 Years' Experience in a Specialized Tuberculosis Clinic in a Low-prevalence Country
生物疗法治疗患者中结核病的预防：某低流行国家一个专科结核病诊所20年的经验
Sandra Pérez-Recio and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 282–290, https://doi.org/10.1093/cid/ciaf491
17
Reducing Household Tuberculosis Transmission: A Pilot Cluster-Randomized Controlled Trial
减少家庭内结核病传播：一项试点整群随机对照试验
Cinthya Ruiz-Tagle and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 291–298, https://doi.org/10.1093/cid/ciaf526
18
(Un)masking Tuberculosis
（揭开）结核病的“面具”
Joseph N Burzynski and Neil W Schluger
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 299–300, https://doi.org/10.1093/cid/ciaf528
19
Estimating the Accuracy and Additionality of TB-LAM to Diagnose TB in Children Without HIV (AccuLAM)
评估TB-LAM在无HIV儿童中诊断结核病的准确性和额外价值（AccuLAM）
Lucía CarratalàCastro and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 301–303, https://doi.org/10.1093/cid/ciaf525
Sexually Transmitted Infections（性传播感染）
20
Potential Impact of Doxycycline Post-exposure Prophylaxis Prescribing Strategies on Incidence of Bacterial Sexually Transmitted Infections
多西环素暴露后预防用药策略对细菌性性传播感染发病率的影响
Michael W Traeger and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 304–311, https://doi.org/10.1093/cid/ciad488
21
Filling in the Gaps: Updates on Doxycycline Prophylaxis for Bacterial Sexually Transmitted Infections
填补空白：多西环素预防细菌性性传播感染的最新进展
Aniruddha Hazra and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 312–320, https://doi.org/10.1093/cid/ciae062
22
Reported Neurologic Manifestations Among Persons With Syphilis by Stage of Infection—12 States, 2019–2022
2019-2022年12个州按感染阶段划分的梅毒患者报告的神经系统表现
Sarah B Wondmeneh and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 321–325, https://doi.org/10.1093/cid/ciaf015
Viral Infections（病毒性感染）
23
Investigating the Role of Cytomegalovirus as a Cause of Stillbirths and Child Deaths in Low- and Middle-Income Countries Through Postmortem Minimally Invasive Tissue Sampling
通过死后微创组织采样，调查巨细胞病毒在低收入和中等收入国家死胎和儿童死亡原因中的作用
Sithembiso Velaphi and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 326–336, https://doi.org/10.1093/cid/ciaf098
Photo Quiz（影像问答）
24
Bursting at the Seams
“撑破”
Maxwell Olenski and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 337–340, https://doi.org/10.1093/cid/ciaf488
Viral Infections（病毒性感染）
25
Clinical and Epidemiological Investigation of Vaccine-Derived Poliovirus Type 2 Outbreak in Pakistan During 2019–2021
2019-2021年巴基斯坦2型疫苗衍生脊髓灰质炎病毒疫情的临床和流行病学调查
Nayab Mehmood and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 341–351, https://doi.org/10.1093/cid/ciaf151
26
Inactivated Polio Vaccine Must Be an Essential Part of Polio Eradication
灭活脊髓灰质炎疫苗必须是根除脊髓灰质炎的重要组成部分
Konstantin Chumakov and Stanley A Plotkin
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 352–353, https://doi.org/10.1093/cid/ciaf215
Photo Quiz（影像问答）
27
Intracranial Lesion in a Patient With Chronic Myeloid Leukemia
慢性髓性白血病患者颅内病变
Mohammed Shakeel Sillat and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 354–357, https://doi.org/10.1093/cid/ciaf441
Viral Infections（病毒性感染）
28
Respiratory Syncytial Virus Co-Detection With Other Respiratory Viruses Is Not Significantly Associated With Worse Clinical Outcomes Among Children Aged <2 Years: New Vaccine Surveillance Network, 2016–2020
在<2岁的婴幼儿中，呼吸道合胞病毒与其他呼吸道病毒共同检测与临床预后恶化无显著关联：2016-2020年新疫苗监测网络数据
Justin Z Amarin and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 358–365, https://doi.org/10.1093/cid/ciaf194
29
Transfer of Herpes Simplex Virus Type 1 (HSV-1) Specific T Cells in a Pediatric Patient Post-HSCT With Severe, Acyclovir-resistant HSV-1 Infection
一例异基因造血干细胞移植后严重、阿昔洛韦耐药的单纯疱疹病毒1型（HSV-1）感染患儿的HSV-1特异性T细胞的输注
Astrid Wintering and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 366–369, https://doi.org/10.1093/cid/ciaf125
Clinical Trials（临床实验）
30
Interferon-α Nasal Spray Prophylaxis Reduces COVID-19 in Cancer Patients: A Randomized, Double-Blinded, Placebo-Controlled Trial
干扰素-α鼻喷雾剂预防可降低癌症患者新冠病毒感染率：一项随机、双盲、安慰剂对照试验
Michelle K Yong and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e208–e216, https://doi.org/10.1093/cid/ciaf409
31
A Phase 3, Randomized Trial Investigating the Safety, Tolerability, and Immunogenicity of V116, an Adult-Specific Pneumococcal Conjugate Vaccine, in Pneumococcal Vaccine-Naïve Adults 18–64 Years of Age at Increased Risk of Pneumococcal Disease, STRIDE-8
一项3期随机试验，调查V116（一种成人特异性肺炎球菌结合疫苗）在未接种过肺炎球菌疫苗且患肺炎球菌疾病风险增加的18-64岁年龄段成人中的安全性、耐受性和免疫原性，STRIDE-8试验
Paul T Scott and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e217–e226, https://doi.org/10.1093/cid/ciaf604
32
Effect of Direct-from-blood Bacterial Testing on Antibiotics Administration in Adults Presenting With Acute Infection: A Randomized Trial
直接从血液进行细菌检测对急性感染成年患者抗生素给药的影响：一项随机试验
David C Gaston and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e227–e235, https://doi.org/10.1093/cid/ciaf677
33
The Tantalizing Pursuit for a Perfect Diagnostic Test: Balancing Innovation With Stewardship
对完美诊断检测的诱人追求：平衡创新与管理
K C Coffey and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e236–e238, https://doi.org/10.1093/cid/ciaf674
Global Health and Neglected Tropical Diseases（全球健康与被忽视的热带病）
34
Diagnostic Accuracy of Tuberculosis Screening Tests in a Prospective Multinational Cohort: Chest Radiography With Computer-Aided Detection, Xpert Tuberculosis Host Response, and C-Reactive Protein
在一项前瞻性多国队列研究中，结核病筛查试验的诊断准确性：计算机辅助检测的胸部X光片、Xpert结核宿主反应检测和C反应蛋白
Rebecca Crowder and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e239–e247, https://doi.org/10.1093/cid/ciae549
HIV/AIDs（人类免疫缺陷病毒/艾滋病）
35
Risk Assessment in a Global CVD Prevention Cohort of People With HIV by PCE, PREVENT, and SCORE2
通过PCE、PREVENT和SCORE2对全球心血管疾病预防队列中艾滋病毒感染者进行风险评估
Steven K Grinspoon and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e248–e257, https://doi.org/10.1093/cid/ciaf542
36
REPRIEVE Analysis of New Cardiovascular Risk Calculators in HIV: Underpredicting Risk Means Preventing Fewer Heart Attacks
HIV新心血管风险计算器的REPRIEVE分析：低估风险意味着预防的心脏病发作更少
Matthew S Durstenfeld
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e258–e261, https://doi.org/10.1093/cid/ciaf543
37
Comparable Inflammatory and Metabolic Outcomes After Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide Versus Continuing Dolutegravir/Lamivudine in Virologically Suppressed Adults With HIV (INSTINCT/GESIDA10918 Study)
在病毒学抑制的HIV感染成人中，转换为比克替拉韦/恩曲他滨/丙酚替诺福韦与继续使用多替拉韦/拉米夫定后的炎症和代谢结局相当（INSTINCT/GESIDA10918研究）
Sergio Serrano-Villar and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e262–e274, https://doi.org/10.1093/cid/ciaf565
38
Tenofovir Alafenamide and Body Weight: Have We Finally Tipped the Scale?
丙酚替诺福韦与体重：我们最终是否打破了平衡？
John R Koethe
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e275–e277, https://doi.org/10.1093/cid/ciaf566
39
Long-Term Clinical, Immunologic, and Viral Reservoir Outcomes in Children Treated With VRC01LS and 10-1074 Monoclonal Antibodies in the Tatelo Study
在Tatelo研究中，接受VRC01LS和10-1074单克隆抗体治疗的儿童的长期临床、免疫学和病毒储存库结局
Gbolahan Ajibola and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e278–e285, https://doi.org/10.1093/cid/ciaf568
40
Trends in Persons Prescribed HIV Postexposure Prophylaxis in the United States, 2015–2023
2015-2023年美国开具HIV暴露后预防处方的患者趋势
John N Le and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e286–e295, https://doi.org/10.1093/cid/ciaf581
Immunocompromised Hosts（免疫功能低下宿主）
41
Epidemiology, Risk Factors, and Outcomes of Neutropenic Enterocolitis in Onco-Hematological Patients According to Chemotherapy Regimen
根据化疗方案分析肿瘤血液学患者中性粒细胞减少性肠结肠炎的流行病学、危险因素和预后
Anne-Sophie Brunel and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e296–e307, https://doi.org/10.1093/cid/ciaf134
42
An Analysis of Cytomegalovirus-Specific Cell-Mediated Immunity in a Phase 3, Randomized, Placebo-Controlled Trial of Letermovir Prophylaxis in Cytomegalovirus-Seropositive Recipients of an Allogeneic Hematopoietic Cell Transplant
在一项3期随机、安慰剂对照试验中，分析来特莫韦预防对巨细胞病毒血清阳性异基因造血细胞移植受者巨细胞病毒特异性细胞介导免疫的影响
Genovefa A Papanicolaou and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e308–e315, https://doi.org/10.1093/cid/ciaf646
43
Cytomegalovirus (CMV)-Specific Cell-Mediated Immunity for Prediction of Postprophylaxis CMV Disease in a Phase 3 Trial of Letermovir Versus Valganciclovir Prophylaxis in Donor CMV-Seropositive/Recipient CMV-Seronegative Kidney Transplant Recipients
在供体巨细胞病毒血清阳性/受体巨细胞病毒血清阴性的肾移植受者中，来特莫韦与缬更昔洛韦预防的3期试验中，巨细胞病毒（CMV）特异性细胞介导免疫对预防后CMV疾病的预测作用
Ajit P Limaye and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e316–e324, https://doi.org/10.1093/cid/ciaf632
44
The Role of Cytomegalovirus-Specific Cellular Immunity in Transplant Recipients with Letermovir Prophylaxis: To be Determined
来特莫韦预防移植受者中巨细胞病毒特异性细胞免疫的作用：有待确定
Yoichiro Natori and Martina Sester
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e325–e327, https://doi.org/10.1093/cid/ciaf633
45
IL12RB1 Deficiency Appearing in North America: Expanding the Clinical Phenotypes
北美出现的IL12RB1缺陷：拓展临床表型
Chen Wang and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e328–e331, https://doi.org/10.1093/cid/ciaf637
Vaccines（疫苗）
46
A Phase IV, Open-label, Single-Arm, Multicentric Clinical Trial for Evaluation of Human Papillomavirus 9vHPV Vaccine Immunogenicity in Men Who Have Sex With Men With HIV: GeSIDA Study 10 017
一项评估人乳头瘤病毒9vHPV疫苗在感染HIV的男男性行为者中免疫原性的IV期、开放标签、单臂、多中心临床试验：GeSIDA 10 017研究
Raquel Ron and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e332–e342, https://doi.org/10.1093/cid/ciaf435
47
Immunogenicity and Safety of the COVID-19 Messenger RNA Vaccine Coadministered With Influenza and 23-valent Pneumococcal Polysaccharide Vaccines
与流感疫苗和23价肺炎球菌多糖疫苗同时接种的COVID-19信使核糖核酸疫苗的免疫原性和安全性
Omid Rezahosseini and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e343–e351, https://doi.org/10.1093/cid/ciaf455
48
Intestinal Mucosal Immune Responses to Novel Oral Poliovirus Vaccine Type 2 in Healthy Newborns
健康新生儿对新型2型口服脊髓灰质炎疫苗的肠道黏膜免疫反应
Audrey Godin and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e352–e360, https://doi.org/10.1093/cid/ciaf484
49
Estimated Vaccine Effectiveness for Respiratory Syncytial Virus–Related Acute Respiratory Illness in Older Adults: Findings From the First Postlicensure Season
老年人呼吸道合胞病毒相关急性呼吸道疾病的估计疫苗有效性：首个上市后季节的研究结果
Sara Y Tartof and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e361–e370, https://doi.org/10.1093/cid/ciaf496
Sexually Transmitted Infections（性传播感染）
50
Systematic Review and Meta-analysis of the Association Between Mycoplasma genitalium and Pelvic Inflammatory Disease (PID)
生殖支原体与盆腔炎性疾病（PID）关联的系统综述和荟萃分析
Kay Htaik and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e371–e379, https://doi.org/10.1093/cid/ciae295
51
Sexually Transmitted Infection (STI)/HIV Testing, STIs, and HIV Pre-exposure Prophylaxis Use Among Men Who Have Sex With Men and Men Who Have Sex With Men and Women in the United States, 2019–2022
2019-2022年美国男男性行为者以及男男性行为者和女性性行为者中性传播感染（STI）/HIV检测、性传播感染和HIV暴露前预防用药情况
Guoyu Tao and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e380–e386, https://doi.org/10.1093/cid/ciae314
52
Cabotegravir Maintains Protective Efficacy in the Setting of Bacterial Sexually Transmitted Infections: A Secondary Analysis of HPTN 083
卡博特韦在细菌性性传播感染情况下维持保护效力：HPTN 083的二次分析
Meredith E Clement and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e387–e395, https://doi.org/10.1093/cid/ciae572
Viral Infections（病毒性感染）
53
Comprehensive Analysis of Cardiovascular Events and Risk Factors in Patients Hospitalized With Respiratory Syncytial Virus
对因呼吸道合胞病毒感染住院患者的心血管事件和危险因素的综合分析
Paulina Sudnik and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e396–e403, https://doi.org/10.1093/cid/ciaf310
54
In Critical Condition: The Urgent Need to Support Mpox Therapeutic and Diagnostic Pipelines
处于危急状况：迫切需要支持猴痘治疗和诊断管线
Carmen Perez Casas and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e404–e408, https://doi.org/10.1093/cid/ciaf529
Correspondence（读者来信）
55
Caution in Interpreting INSTIs and Weight in Observational Studies
在观察性研究中解读整合酶抑制剂与体重关系时需谨慎
Esteban Martínez
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Page e409, https://doi.org/10.1093/cid/ciaf569
56
Weight Trajectories With Integrase Inhibitors: Unaddressed Insights and Limitations in a Chinese Cohort
整合酶抑制剂与体重变化轨迹：中国队列中未解决的见解和局限性
Yuan-Ti Lee and Shiuan-Chih Chen
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e409–e410, https://doi.org/10.1093/cid/ciaf570
57
Real-World Evidence as a Complement to Randomized Trials in Interpreting Weight Gain on Modern INSTI Regimens
现实证据作为随机试验的补充，用于解读现代整合酶抑制剂方案导致的体重增加
Xinsheng Wu and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e410–e411, https://doi.org/10.1093/cid/ciaf571
58
C-reactive Protein in TB Meningitis: Signal, Surrogate, or Saboteur?
结核性脑膜炎中的C反应蛋白：信号、替代指标还是破坏因素？
Patrick K Moonan and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e411–e412, https://doi.org/10.1093/cid/ciaf575
59
C-Reactive Protein in Tuberculous Meningitis: A Viable Biomarker for Individualized Care
结核性脑膜炎中的C反应蛋白：个体化护理的可行生物标志物
Lillian Tugume and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e412–e413, https://doi.org/10.1093/cid/ciaf576
60
The Win Ratio Should Be Complemented by Other Win Statistics to Provide a Comprehensive Picture of Relative and Absolute Treatment Effects: The Case Study of the REPRIEVE Trial
胜利比率应与其他胜利统计数据相结合，以全面呈现相对和绝对治疗效果：REPRIEVE试验案例研究
Melissa J Hardy and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e413–e414, https://doi.org/10.1093/cid/ciaf587
61
Small Effects, Big Impact: Multiple Win Measures Aid Interpretation, But Do Not Forget the Bigger Picture
效应虽小，影响重大：多种胜利衡量指标有助于解读，但不要忘记整体情况
Emma Davies Smith and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e414–e416, https://doi.org/10.1093/cid/ciaf588
62
Does Oral Antibiotic Switching Therapy Show Similar Efficacy to Intravenous Administration for Treating Infective Endocarditis?
口服抗生素转换疗法治疗感染性心内膜炎的疗效是否与静脉给药相似？
Jun Suzuki and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e416–e417, https://doi.org/10.1093/cid/ciaf598
63
Toward a Wider Use of Oral Antibiotic Switch in Infective Endocarditis
朝着更广泛地使用感染性心内膜炎口服抗生素转换疗法迈进
Romane Pouy and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e417–e418, https://doi.org/10.1093/cid/ciaf599
64
Operationalizing Sepsis Definitions With Artificial Intelligence: Toward Smarter Antibiotic Use
利用人工智能实现败血症定义的落地应用：迈向更明智的抗生素使用
James S Ford and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e418–e419, https://doi.org/10.1093/cid/ciaf601
65
Balancing Innovation in Artificial Intelligence With Practical Sepsis Definitions
平衡人工智能创新与实用的败血症定义
Chanu Rhee and Michael Klompas
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e419–e420, https://doi.org/10.1093/cid/ciaf602
66
Precision Prevention of Tuberculosis in Biologic Therapy: Lessons Beyond Screening Strategies
生物疗法中结核病的精准预防：筛查策略之外的启示
Shiuan-Chih Chen and Yuan-Ti Lee
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e420–e421, https://doi.org/10.1093/cid/ciaf559
67
Recalibrating COVID-19 Booster Policy: Lessons From Hybrid Immunity and Global Equity Gaps
重新调整COVID-19加强针政策：从混合免疫和全球公平差距中吸取教训
Nathkapach K Rattanapitoon and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e421–e422, https://doi.org/10.1093/cid/ciaf605
2026-02-26
Clinical Infectious Diseases Volume 82 Issue 2
临床传染病学 82卷 2期
https://academic.oup.com/cid/issue/
ID Art Through the Ages（穿越时代的传染病技艺）
1
Interior of the Old Jersey Prison Ship in the Revolutionary War
美国革命战争中老泽西监狱船的内部景象
Mary Grizzard and Michael Grizzard
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Page i, https://doi.org/10.1093/cid/ciaf693
In the Literature（本期精选）
2
In the Literature
本期精选
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages ii–v, https://doi.org/10.1093/cid/ciag011
IDSA 2025 Collections Editorial（美国传染病学会2025年专题合集社论）
3
2025 Content Collections from the IDSA Journals
IDSA期刊2025年内容合集
Roger Bedimo and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 185–186, https://doi.org/10.1093/cid/ciag041
State-of-the-Art Review（前沿综述）
4
State-of-the-Art Review: Chagas Disease—an Enduring Challenge
前沿综述：恰加斯病——一个持续存在的挑战
Nelson Iván Agudelo Higuita and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 187–205, https://doi.org/10.1093/cid/ciaf654
IDSA Features（美国传染病学会特色内容）
5
Policy Recommendations to Support Equitable Access to Long-Acting Injectables for HIV Prevention and Treatment: A Policy Paper of the Infectious Diseases Society of America and the HIV Medicine Association
支持公平获取用于艾滋病毒预防和治疗的长效注射剂的政策建议：美国传染病学会与艾滋病毒医学协会的政策文件
Julia L Marcus and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 206–211, https://doi.org/10.1093/cid/ciae648
Voices of ID（传染病之声）
6
A “Terminal Infection”
“绝症感染”
Jennifer Furin
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 212–214, https://doi.org/10.1093/cid/ciaf332
Invited Commentary（特邀评论）
7
A Rapid Test to Differentiate Viral From Bacterial Infections: Searching for the Holy Grail
区分病毒与细菌感染的快速检测：寻找“圣杯”
Lao-Tzu Allan-Blitz and Jeffrey D Klausner
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 215–218, https://doi.org/10.1093/cid/ciaf585
Bacterial Infections（细菌感染）
8
Nonoperative Versus Neurosurgical Treatment of Brain Abscess: An Emulated Trial Nested Within a Nationwide, Population-Based Cohort
脑脓肿的非手术治疗与神经外科治疗：一项基于全国人群队列的模拟试验
Emilie Marie Eriksen and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 219–227, https://doi.org/10.1093/cid/ciaf304
9
What Is the Impact of Anti-Enterococcal Empirical Therapy on Survival of Patients With Enterococcal Bloodstream Infections?
抗肠球菌经验性治疗对肠球菌血流感染患者生存率的影响是什么？
Linda Bussini and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 228–237, https://doi.org/10.1093/cid/ciaf323
10
Adjunctive Fosfomycin for the Treatment of Staphylococcus aureus Bacteremia: A Pooled Post Hoc Analysis of Individual Participant Data From 2 Randomized Trials
辅助使用磷霉素治疗金黄色葡萄球菌菌血症：两项随机试验个体参与者数据的汇总事后分析
Francesc Escrihuela-Vidal and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 238–245, https://doi.org/10.1093/cid/ciaf387
HIV/AIDs（人类免疫缺陷病毒/艾滋病）
11
Kinetics of Non-nucleoside Reverse Transcriptase Inhibitor Resistance-associated Mutations in HIV-1 Proviral Cellular Reservoirs in Non-nucleoside Reverse Transcriptase Inhibitor-experienced Persons
在接受过非核苷类逆转录酶抑制剂治疗的HIV-1感染者中，非核苷类逆转录酶抑制剂耐药相关突变在HIV-1前病毒细胞储存库中的动力学
Thomas Drumel and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 246–251, https://doi.org/10.1093/cid/ciaf430
12
Impact of Different Integrase Strand Transfer Inhibitors on Body Mass Index Among People With HIV Who Newly Started Antiretroviral Therapy in Shenzhen, China: A Real-World Data Analysis
中国深圳新开始抗逆转录病毒治疗的HIV感染者使用不同整合酶链转移抑制剂对体重指数的影响：一项现实数据分析
Lukun Zhang and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 252–261, https://doi.org/10.1093/cid/ciaf466
13
Consequences of Stopping Antiretroviral Treatment in a Persistently Seronegative Individual with HIV-1
HIV-1持续血清阴性个体停止抗逆转录病毒治疗的后果
Marc Wirden and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 262–264, https://doi.org/10.1093/cid/ciaf422
14
Approaches to the Management of Virologic Failure on Dolutegravir-Based Antiretroviral Therapy in the 50 Countries With the Highest Adult HIV Prevalence
在成人HIV患病率最高的50个国家中，多替拉韦为基础的抗逆转录病毒治疗出现病毒学失败的治疗方法
Cameron T Nutt and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 265–273, https://doi.org/10.1093/cid/ciaf444
Mycobacterial Infections（结核分枝杆菌感染）
15
Retrospective Cohort Analysis for Identification of Discordant Rifampicin-resistant Xpert MTB/RIF Assay Results in South Kivu, Eastern Democratic Republic of the Congo, a High Burden Tuberculosis Setting
刚果民主共和国东部南基伍这一结核病高负荷地区，识别利福平耐药不一致的Xpert MTB/RIF检测结果的回顾性队列分析
Bertin C Bisimwa and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 274–281, https://doi.org/10.1093/cid/ciaf451
16
Prevention of Tuberculosis in Patients Treated With Biological Therapies: 20 Years' Experience in a Specialized Tuberculosis Clinic in a Low-prevalence Country
生物疗法治疗患者中结核病的预防：某低流行国家一个专科结核病诊所20年的经验
Sandra Pérez-Recio and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 282–290, https://doi.org/10.1093/cid/ciaf491
17
Reducing Household Tuberculosis Transmission: A Pilot Cluster-Randomized Controlled Trial
减少家庭内结核病传播：一项试点整群随机对照试验
Cinthya Ruiz-Tagle and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 291–298, https://doi.org/10.1093/cid/ciaf526
18
(Un)masking Tuberculosis
（揭开）结核病的“面具”
Joseph N Burzynski and Neil W Schluger
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 299–300, https://doi.org/10.1093/cid/ciaf528
19
Estimating the Accuracy and Additionality of TB-LAM to Diagnose TB in Children Without HIV (AccuLAM)
评估TB-LAM在无HIV儿童中诊断结核病的准确性和额外价值（AccuLAM）
Lucía CarratalàCastro and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 301–303, https://doi.org/10.1093/cid/ciaf525
Sexually Transmitted Infections（性传播感染）
20
Potential Impact of Doxycycline Post-exposure Prophylaxis Prescribing Strategies on Incidence of Bacterial Sexually Transmitted Infections
多西环素暴露后预防用药策略对细菌性性传播感染发病率的影响
Michael W Traeger and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 304–311, https://doi.org/10.1093/cid/ciad488
21
Filling in the Gaps: Updates on Doxycycline Prophylaxis for Bacterial Sexually Transmitted Infections
填补空白：多西环素预防细菌性性传播感染的最新进展
Aniruddha Hazra and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 312–320, https://doi.org/10.1093/cid/ciae062
22
Reported Neurologic Manifestations Among Persons With Syphilis by Stage of Infection—12 States, 2019–2022
2019-2022年12个州按感染阶段划分的梅毒患者报告的神经系统表现
Sarah B Wondmeneh and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 321–325, https://doi.org/10.1093/cid/ciaf015
Viral Infections（病毒性感染）
23
Investigating the Role of Cytomegalovirus as a Cause of Stillbirths and Child Deaths in Low- and Middle-Income Countries Through Postmortem Minimally Invasive Tissue Sampling
通过死后微创组织采样，调查巨细胞病毒在低收入和中等收入国家死胎和儿童死亡原因中的作用
Sithembiso Velaphi and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 326–336, https://doi.org/10.1093/cid/ciaf098
Photo Quiz（影像问答）
24
Bursting at the Seams
“撑破”
Maxwell Olenski and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 337–340, https://doi.org/10.1093/cid/ciaf488
Viral Infections（病毒性感染）
25
Clinical and Epidemiological Investigation of Vaccine-Derived Poliovirus Type 2 Outbreak in Pakistan During 2019–2021
2019-2021年巴基斯坦2型疫苗衍生脊髓灰质炎病毒疫情的临床和流行病学调查
Nayab Mehmood and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 341–351, https://doi.org/10.1093/cid/ciaf151
26
Inactivated Polio Vaccine Must Be an Essential Part of Polio Eradication
灭活脊髓灰质炎疫苗必须是根除脊髓灰质炎的重要组成部分
Konstantin Chumakov and Stanley A Plotkin
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 352–353, https://doi.org/10.1093/cid/ciaf215
Photo Quiz（影像问答）
27
Intracranial Lesion in a Patient With Chronic Myeloid Leukemia
慢性髓性白血病患者颅内病变
Mohammed Shakeel Sillat and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 354–357, https://doi.org/10.1093/cid/ciaf441
Viral Infections（病毒性感染）
28
Respiratory Syncytial Virus Co-Detection With Other Respiratory Viruses Is Not Significantly Associated With Worse Clinical Outcomes Among Children Aged <2 Years: New Vaccine Surveillance Network, 2016–2020
在<2岁的婴幼儿中，呼吸道合胞病毒与其他呼吸道病毒共同检测与临床预后恶化无显著关联：2016-2020年新疫苗监测网络数据
Justin Z Amarin and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 358–365, https://doi.org/10.1093/cid/ciaf194
29
Transfer of Herpes Simplex Virus Type 1 (HSV-1) Specific T Cells in a Pediatric Patient Post-HSCT With Severe, Acyclovir-resistant HSV-1 Infection
一例异基因造血干细胞移植后严重、阿昔洛韦耐药的单纯疱疹病毒1型（HSV-1）感染患儿的HSV-1特异性T细胞的输注
Astrid Wintering and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages 366–369, https://doi.org/10.1093/cid/ciaf125
Clinical Trials（临床实验）
30
Interferon-α Nasal Spray Prophylaxis Reduces COVID-19 in Cancer Patients: A Randomized, Double-Blinded, Placebo-Controlled Trial
干扰素-α鼻喷雾剂预防可降低癌症患者新冠病毒感染率：一项随机、双盲、安慰剂对照试验
Michelle K Yong and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e208–e216, https://doi.org/10.1093/cid/ciaf409
31
A Phase 3, Randomized Trial Investigating the Safety, Tolerability, and Immunogenicity of V116, an Adult-Specific Pneumococcal Conjugate Vaccine, in Pneumococcal Vaccine-Naïve Adults 18–64 Years of Age at Increased Risk of Pneumococcal Disease, STRIDE-8
一项3期随机试验，调查V116（一种成人特异性肺炎球菌结合疫苗）在未接种过肺炎球菌疫苗且患肺炎球菌疾病风险增加的18-64岁年龄段成人中的安全性、耐受性和免疫原性，STRIDE-8试验
Paul T Scott and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e217–e226, https://doi.org/10.1093/cid/ciaf604
32
Effect of Direct-from-blood Bacterial Testing on Antibiotics Administration in Adults Presenting With Acute Infection: A Randomized Trial
直接从血液进行细菌检测对急性感染成年患者抗生素给药的影响：一项随机试验
David C Gaston and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e227–e235, https://doi.org/10.1093/cid/ciaf677
33
The Tantalizing Pursuit for a Perfect Diagnostic Test: Balancing Innovation With Stewardship
对完美诊断检测的诱人追求：平衡创新与管理
K C Coffey and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e236–e238, https://doi.org/10.1093/cid/ciaf674
Global Health and Neglected Tropical Diseases（全球健康与被忽视的热带病）
34
Diagnostic Accuracy of Tuberculosis Screening Tests in a Prospective Multinational Cohort: Chest Radiography With Computer-Aided Detection, Xpert Tuberculosis Host Response, and C-Reactive Protein
在一项前瞻性多国队列研究中，结核病筛查试验的诊断准确性：计算机辅助检测的胸部X光片、Xpert结核宿主反应检测和C反应蛋白
Rebecca Crowder and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e239–e247, https://doi.org/10.1093/cid/ciae549
HIV/AIDs（人类免疫缺陷病毒/艾滋病）
35
Risk Assessment in a Global CVD Prevention Cohort of People With HIV by PCE, PREVENT, and SCORE2
通过PCE、PREVENT和SCORE2对全球心血管疾病预防队列中艾滋病毒感染者进行风险评估
Steven K Grinspoon and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e248–e257, https://doi.org/10.1093/cid/ciaf542
36
REPRIEVE Analysis of New Cardiovascular Risk Calculators in HIV: Underpredicting Risk Means Preventing Fewer Heart Attacks
HIV新心血管风险计算器的REPRIEVE分析：低估风险意味着预防的心脏病发作更少
Matthew S Durstenfeld
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e258–e261, https://doi.org/10.1093/cid/ciaf543
37
Comparable Inflammatory and Metabolic Outcomes After Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide Versus Continuing Dolutegravir/Lamivudine in Virologically Suppressed Adults With HIV (INSTINCT/GESIDA10918 Study)
在病毒学抑制的HIV感染成人中，转换为比克替拉韦/恩曲他滨/丙酚替诺福韦与继续使用多替拉韦/拉米夫定后的炎症和代谢结局相当（INSTINCT/GESIDA10918研究）
Sergio Serrano-Villar and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e262–e274, https://doi.org/10.1093/cid/ciaf565
38
Tenofovir Alafenamide and Body Weight: Have We Finally Tipped the Scale?
丙酚替诺福韦与体重：我们最终是否打破了平衡？
John R Koethe
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e275–e277, https://doi.org/10.1093/cid/ciaf566
39
Long-Term Clinical, Immunologic, and Viral Reservoir Outcomes in Children Treated With VRC01LS and 10-1074 Monoclonal Antibodies in the Tatelo Study
在Tatelo研究中，接受VRC01LS和10-1074单克隆抗体治疗的儿童的长期临床、免疫学和病毒储存库结局
Gbolahan Ajibola and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e278–e285, https://doi.org/10.1093/cid/ciaf568
40
Trends in Persons Prescribed HIV Postexposure Prophylaxis in the United States, 2015–2023
2015-2023年美国开具HIV暴露后预防处方的患者趋势
John N Le and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e286–e295, https://doi.org/10.1093/cid/ciaf581
Immunocompromised Hosts（免疫功能低下宿主）
41
Epidemiology, Risk Factors, and Outcomes of Neutropenic Enterocolitis in Onco-Hematological Patients According to Chemotherapy Regimen
根据化疗方案分析肿瘤血液学患者中性粒细胞减少性肠结肠炎的流行病学、危险因素和预后
Anne-Sophie Brunel and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e296–e307, https://doi.org/10.1093/cid/ciaf134
42
An Analysis of Cytomegalovirus-Specific Cell-Mediated Immunity in a Phase 3, Randomized, Placebo-Controlled Trial of Letermovir Prophylaxis in Cytomegalovirus-Seropositive Recipients of an Allogeneic Hematopoietic Cell Transplant
在一项3期随机、安慰剂对照试验中，分析来特莫韦预防对巨细胞病毒血清阳性异基因造血细胞移植受者巨细胞病毒特异性细胞介导免疫的影响
Genovefa A Papanicolaou and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e308–e315, https://doi.org/10.1093/cid/ciaf646
43
Cytomegalovirus (CMV)-Specific Cell-Mediated Immunity for Prediction of Postprophylaxis CMV Disease in a Phase 3 Trial of Letermovir Versus Valganciclovir Prophylaxis in Donor CMV-Seropositive/Recipient CMV-Seronegative Kidney Transplant Recipients
在供体巨细胞病毒血清阳性/受体巨细胞病毒血清阴性的肾移植受者中，来特莫韦与缬更昔洛韦预防的3期试验中，巨细胞病毒（CMV）特异性细胞介导免疫对预防后CMV疾病的预测作用
Ajit P Limaye and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e316–e324, https://doi.org/10.1093/cid/ciaf632
44
The Role of Cytomegalovirus-Specific Cellular Immunity in Transplant Recipients with Letermovir Prophylaxis: To be Determined
来特莫韦预防移植受者中巨细胞病毒特异性细胞免疫的作用：有待确定
Yoichiro Natori and Martina Sester
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e325–e327, https://doi.org/10.1093/cid/ciaf633
45
IL12RB1 Deficiency Appearing in North America: Expanding the Clinical Phenotypes
北美出现的IL12RB1缺陷：拓展临床表型
Chen Wang and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e328–e331, https://doi.org/10.1093/cid/ciaf637
Vaccines（疫苗）
46
A Phase IV, Open-label, Single-Arm, Multicentric Clinical Trial for Evaluation of Human Papillomavirus 9vHPV Vaccine Immunogenicity in Men Who Have Sex With Men With HIV: GeSIDA Study 10 017
一项评估人乳头瘤病毒9vHPV疫苗在感染HIV的男男性行为者中免疫原性的IV期、开放标签、单臂、多中心临床试验：GeSIDA 10 017研究
Raquel Ron and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e332–e342, https://doi.org/10.1093/cid/ciaf435
47
Immunogenicity and Safety of the COVID-19 Messenger RNA Vaccine Coadministered With Influenza and 23-valent Pneumococcal Polysaccharide Vaccines
与流感疫苗和23价肺炎球菌多糖疫苗同时接种的COVID-19信使核糖核酸疫苗的免疫原性和安全性
Omid Rezahosseini and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e343–e351, https://doi.org/10.1093/cid/ciaf455
48
Intestinal Mucosal Immune Responses to Novel Oral Poliovirus Vaccine Type 2 in Healthy Newborns
健康新生儿对新型2型口服脊髓灰质炎疫苗的肠道黏膜免疫反应
Audrey Godin and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e352–e360, https://doi.org/10.1093/cid/ciaf484
49
Estimated Vaccine Effectiveness for Respiratory Syncytial Virus–Related Acute Respiratory Illness in Older Adults: Findings From the First Postlicensure Season
老年人呼吸道合胞病毒相关急性呼吸道疾病的估计疫苗有效性：首个上市后季节的研究结果
Sara Y Tartof and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e361–e370, https://doi.org/10.1093/cid/ciaf496
Sexually Transmitted Infections（性传播感染）
50
Systematic Review and Meta-analysis of the Association Between Mycoplasma genitalium and Pelvic Inflammatory Disease (PID)
生殖支原体与盆腔炎性疾病（PID）关联的系统综述和荟萃分析
Kay Htaik and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e371–e379, https://doi.org/10.1093/cid/ciae295
51
Sexually Transmitted Infection (STI)/HIV Testing, STIs, and HIV Pre-exposure Prophylaxis Use Among Men Who Have Sex With Men and Men Who Have Sex With Men and Women in the United States, 2019–2022
2019-2022年美国男男性行为者以及男男性行为者和女性性行为者中性传播感染（STI）/HIV检测、性传播感染和HIV暴露前预防用药情况
Guoyu Tao and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e380–e386, https://doi.org/10.1093/cid/ciae314
52
Cabotegravir Maintains Protective Efficacy in the Setting of Bacterial Sexually Transmitted Infections: A Secondary Analysis of HPTN 083
卡博特韦在细菌性性传播感染情况下维持保护效力：HPTN 083的二次分析
Meredith E Clement and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e387–e395, https://doi.org/10.1093/cid/ciae572
Viral Infections（病毒性感染）
53
Comprehensive Analysis of Cardiovascular Events and Risk Factors in Patients Hospitalized With Respiratory Syncytial Virus
对因呼吸道合胞病毒感染住院患者的心血管事件和危险因素的综合分析
Paulina Sudnik and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e396–e403, https://doi.org/10.1093/cid/ciaf310
54
In Critical Condition: The Urgent Need to Support Mpox Therapeutic and Diagnostic Pipelines
处于危急状况：迫切需要支持猴痘治疗和诊断管线
Carmen Perez Casas and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e404–e408, https://doi.org/10.1093/cid/ciaf529
Correspondence（读者来信）
55
Caution in Interpreting INSTIs and Weight in Observational Studies
在观察性研究中解读整合酶抑制剂与体重关系时需谨慎
Esteban Martínez
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Page e409, https://doi.org/10.1093/cid/ciaf569
56
Weight Trajectories With Integrase Inhibitors: Unaddressed Insights and Limitations in a Chinese Cohort
整合酶抑制剂与体重变化轨迹：中国队列中未解决的见解和局限性
Yuan-Ti Lee and Shiuan-Chih Chen
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e409–e410, https://doi.org/10.1093/cid/ciaf570
57
Real-World Evidence as a Complement to Randomized Trials in Interpreting Weight Gain on Modern INSTI Regimens
现实证据作为随机试验的补充，用于解读现代整合酶抑制剂方案导致的体重增加
Xinsheng Wu and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e410–e411, https://doi.org/10.1093/cid/ciaf571
58
C-reactive Protein in TB Meningitis: Signal, Surrogate, or Saboteur?
结核性脑膜炎中的C反应蛋白：信号、替代指标还是破坏因素？
Patrick K Moonan and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e411–e412, https://doi.org/10.1093/cid/ciaf575
59
C-Reactive Protein in Tuberculous Meningitis: A Viable Biomarker for Individualized Care
结核性脑膜炎中的C反应蛋白：个体化护理的可行生物标志物
Lillian Tugume and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e412–e413, https://doi.org/10.1093/cid/ciaf576
60
The Win Ratio Should Be Complemented by Other Win Statistics to Provide a Comprehensive Picture of Relative and Absolute Treatment Effects: The Case Study of the REPRIEVE Trial
胜利比率应与其他胜利统计数据相结合，以全面呈现相对和绝对治疗效果：REPRIEVE试验案例研究
Melissa J Hardy and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e413–e414, https://doi.org/10.1093/cid/ciaf587
61
Small Effects, Big Impact: Multiple Win Measures Aid Interpretation, But Do Not Forget the Bigger Picture
效应虽小，影响重大：多种胜利衡量指标有助于解读，但不要忘记整体情况
Emma Davies Smith and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e414–e416, https://doi.org/10.1093/cid/ciaf588
62
Does Oral Antibiotic Switching Therapy Show Similar Efficacy to Intravenous Administration for Treating Infective Endocarditis?
口服抗生素转换疗法治疗感染性心内膜炎的疗效是否与静脉给药相似？
Jun Suzuki and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e416–e417, https://doi.org/10.1093/cid/ciaf598
63
Toward a Wider Use of Oral Antibiotic Switch in Infective Endocarditis
朝着更广泛地使用感染性心内膜炎口服抗生素转换疗法迈进
Romane Pouy and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e417–e418, https://doi.org/10.1093/cid/ciaf599
64
Operationalizing Sepsis Definitions With Artificial Intelligence: Toward Smarter Antibiotic Use
利用人工智能实现败血症定义的落地应用：迈向更明智的抗生素使用
James S Ford and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e418–e419, https://doi.org/10.1093/cid/ciaf601
65
Balancing Innovation in Artificial Intelligence With Practical Sepsis Definitions
平衡人工智能创新与实用的败血症定义
Chanu Rhee and Michael Klompas
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e419–e420, https://doi.org/10.1093/cid/ciaf602
66
Precision Prevention of Tuberculosis in Biologic Therapy: Lessons Beyond Screening Strategies
生物疗法中结核病的精准预防：筛查策略之外的启示
Shiuan-Chih Chen and Yuan-Ti Lee
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e420–e421, https://doi.org/10.1093/cid/ciaf559
67
Recalibrating COVID-19 Booster Policy: Lessons From Hybrid Immunity and Global Equity Gaps
重新调整COVID-19加强针政策：从混合免疫和全球公平差距中吸取教训
Nathkapach K Rattanapitoon and others
Clinical Infectious Diseases, Volume 82, Issue 2, 15 February 2026, Pages e421–e422, https://doi.org/10.1093/cid/ciaf605
100 项与 多西环素 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 寻常痤疮 | 澳大利亚 | 2008-06-24 | |
| 细菌感染 | 澳大利亚 | 2008-06-24 | |
| 革兰氏阴性菌感染 | 澳大利亚 | 2008-06-24 | |
| 疟疾 | 澳大利亚 | 2008-06-24 | |
| 玫瑰痤疮 | 美国 | 2006-05-26 | |
| 感染 | 美国 | 1967-12-06 |
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10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 特应性皮炎 | 临床2期 | 美国 | 2023-04-25 | |
| 神经纤维瘤病 | 临床2期 | - | - | |
| 晚期恶性实体瘤 | 临床1期 | 中国 | 2019-07-04 | |
| 晚期恶性实体瘤 | 临床1期 | 中国 | 2019-07-04 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床2期 | 7 | (Arm A (Metformin Hydrochloride)) | 簾餘鏇蓋築選壓醖憲憲(選繭築獵艱膚窪簾膚鹹) = 憲鑰製顧壓夢繭鏇築鬱 艱蓋淵獵繭窪膚願繭憲 (顧膚積憲範淵選鹹願願, 築積廠艱鏇餘蓋鏇築範 ~ 鹹醖蓋衊鹽廠糧淵齋膚) 更多 | - | 2026-01-29 | ||
(Arm B (Doxycycline)) | 簾餘鏇蓋築選壓醖憲憲(選繭築獵艱膚窪簾膚鹹) = 繭鬱遞獵鹽遞遞鏇壓鹹 艱蓋淵獵繭窪膚願繭憲 (顧膚積憲範淵選鹹願願, 構艱憲壓艱鏇夢繭繭構 ~ 簾簾製鑰壓淵鑰窪鹹鏇) 更多 | ||||||
临床4期 | 94 | cefalexin+levofloxacin+Amoxicillin+doxycycline+delafloxacin+amoxicillin-clavulanate+linezolid+ciprofloxacin+cefpodoxime+cefadroxil (Group 1 (Experimental)) | 憲簾艱構顧製鹹積糧壓 = 築簾範積簾構鹽衊齋醖 積鑰觸夢積築襯獵壓艱 (艱窪壓積願鬱鹹膚獵鏇, 顧鹽觸蓋糧顧廠鑰襯醖 ~ 鹹憲衊齋願網構壓製襯) 更多 | - | 2025-08-26 | ||
憲簾艱構顧製鹹積糧壓 = 鏇繭遞衊遞衊顧窪積蓋 積鑰觸夢積築襯獵壓艱 (艱窪壓積願鬱鹹膚獵鏇, 網淵願齋願艱遞窪鑰範 ~ 鑰築選遞願鹹齋齋膚廠) 更多 | |||||||
N/A | 100 | 鬱繭簾艱築構鬱繭淵壓(鹹鹹範築觸鹹選築糧膚) = 窪積鹹鹹遞遞積糧製膚 膚簾壓願艱築壓壓製鬱 (繭蓋鏇積簾鹹遞夢衊構 ) 更多 | 不佳 | 2023-07-10 | |||
Iodopovidone | 鬱繭簾艱築構鬱繭淵壓(鹹鹹範築觸鹹選築糧膚) = 範簾範淵鏇糧夢繭選範 膚簾壓願艱築壓壓製鬱 (繭蓋鏇積簾鹹遞夢衊構 ) 更多 | ||||||
临床4期 | 198 | Combination therapy | 醖製繭觸夢鬱齋願顧醖(選鹽觸選廠製壓構壓醖) = 齋範壓蓋襯鏇壓襯鹹構 遞廠構範襯襯淵壓築製 (網積淵糧觸壓窪製醖鏇 ) 更多 | - | 2023-07-03 | ||
临床2期 | 44 | 鹽憲繭糧淵範獵網製鬱(夢窪蓋廠淵夢襯憲夢蓋) = 壓壓襯鹽獵築鹹衊積顧 積淵繭醖鑰膚夢窪願衊 (窪窪獵艱構簾淵網鬱艱, 71 ~ 73) 更多 | 积极 | 2022-11-15 | |||
临床3期 | 513 | No Intervention: Standard of Care | 窪糧夢艱觸觸夢願廠襯 = 築壓艱襯餘淵鹽艱觸廠 積鏇鹹窪觸鹽齋積製鑰 (鹽積獵淵製範鹹繭簾遞, 膚鹹範憲製齋淵願鹹願 ~ 鑰築鬱網衊獵遞鑰醖夢) 更多 | - | 2021-03-03 | ||
临床3期 | 400 | Standard of care (Placebo) | 簾繭繭簾願構願醖簾壓 = 鏇製網鑰窪壓憲鬱範壓 選艱鬱願獵醖廠獵製選 (淵鏇構簾窪齋糧選遞鹹, 鹽艱齋構窪廠蓋壓餘憲 ~ 繭構糧獵鑰鹽膚壓鏇憲) 更多 | - | 2020-10-09 | ||
(Ivermectin and Doxycycline) | 壓襯選製範衊齋鑰憲構(窪廠艱餘繭築夢鏇齋餘) = 淵憲憲築淵鑰網顧構顧 簾糧鏇築範齋願夢窪願 (築繭艱齋衊膚廠築窪構, 築壓獵壓構糧簾憲鏇觸 ~ 窪觸築夢齋範簾鏇艱願) 更多 | ||||||
临床2期 | 23 | 壓糧襯窪遞鑰遞鹹製醖 = 餘繭衊壓鹹蓋構窪衊膚 觸窪糧鏇蓋餘築網簾觸 (膚膚繭獵鑰鹹壓衊遞淵, 積顧獵鏇膚製餘遞鹽艱 ~ 夢獵糧獵鑰網壓簾遞範) 更多 | - | 2020-03-26 | |||
临床4期 | 22 | Adapalene/Benzoyl Peroxide Gel 0.3-2.5%+Doxycycline Anhydrous 40 MG | 鏇衊蓋餘鑰願壓網衊鑰 = 簾選廠繭鹹築憲範淵夢 衊範鏇願顧醖醖鑰齋蓋 (遞窪憲願鹽鬱鹹齋築簾, 鏇淵壓構鹹鹽衊鏇製觸 ~ 製膚積觸膚衊鬱選壓繭) 更多 | - | 2019-03-20 | ||
临床4期 | 235 | Placebo | 鑰積獵積範齋構鬱製網 = 築壓鹽齋鑰餘鏇衊糧衊 觸觸蓋製襯糧鏇廠憲襯 (壓顧選膚窪獵鬱願選醖, 願鹽鹹壓糧鏇淵糧願鑰 ~ 鹽鏇淵餘觸夢鏇簾艱築) 更多 | - | 2014-08-04 |
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