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更新于：2025-09-06
Fluvastatin Sodium
氟伐他汀钠
更新于：2025-09-06
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C24H26FNNaO4 |
InChIKeyCUOKYGJQSIKNFS-ZADPHQEYSA-N |
CAS号93957-55-2 |
关联
83
项与 氟伐他汀钠 相关的临床试验NCT06785727
StAtins in Frail OldEr Patients with Ischemic Stroke or Transient Ischemic Attack - the Randomized Controlled Trial
NCT06679036
An Open, Multicenter Phase Ib/II Clinical Study on the Safety, Tolerance, Pharmacokinetics, and Initial Efficacy of HRS-2189 in Combination With Fluvastatin±HRS-6209, or HRS-8080±HRS-6209, or HRS-6209+HRS-1358 in Patients With Advanced Unresectable or Metastatic Breast Cancer
CTR20250085
氟伐他汀钠缓释片作用于健康成年受试者在空腹和餐后状态下的单中心、开放、随机、单剂量、四周期、完全重复、两序列、交叉生物等效性研究
100 项与 氟伐他汀钠 相关的临床结果
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100 项与 氟伐他汀钠 相关的转化医学
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100 项与 氟伐他汀钠 相关的专利（医药）
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3,885
项与 氟伐他汀钠 相关的文献（医药）2025-10-01COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
Effects of re-enter water on antioxidant, immune, intestinal flora and metabolome of Chinese mitten crab (Eriocheir sinensis) after high temperature air exposure
Article
作者: Wang, Shihui ; Luo, Liang ; Yang, Yuhong ; Zhao, Zhigang ; Li, Zhiqiang ; Guo, Kun ; Deng, Xiangyi ; Zhang, Rui
Both air exposure stress and heat stress can cause stress responses of Eriocheir sinensis and affect its normal life activities. The objective of this research was to investigate the impact of re-enter water treatment on immunoenzyme activity, immune-related gene expression, hemolymph parameters, intestinal microbiota composition, and metabolomic profiles in Eriocheir sinensis after being subjected to high-temperature air exposure. The findings indicated that the re-enter water effectively mitigated the negative impacts of high-temperature air exposure on both antioxidant and immune capacities. Following treatment with high-temperature air, levels of acid phosphatase (ACP), alkaline phosphatase (AKP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were significantly elevated compared to their baseline values (P < 0.05), followed by a decline as re-enter water started with recovery to baseline levels detected at 24 h after re-enter water. Additionally, the levels of heat shock proteins HSP90 and HSP70 exhibited a notable rise after being subjected to high-temperature air. Nevertheless, after 24 h of soaking treatment, these levels reverted to values similar to those recorded initially. However, after re-enter water treatment, the changes in intestinal microbial composition and metabolic level caused by high temperature air exposure were not effectively improved. The analysis of intestinal microbiota revealed that the relative abundance of Bacteroidetes in the recovery group was significantly lower compared to the initial group, whereas the relative abundances of Proteobacteria and Firmicutes were found to be higher than those in the initial group. Concurrently, metabolomics analysis indicated a significant increase in palmitic acid metabolism levels within the high-temperature air group (P < 0.05), while glycine content showed a notable decrease (P < 0.05), and the metabolic changes caused by high temperature air exposure was still not fully recovered after re-enter water.
2025-09-01INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Physico-chemical characterization of fucoidans from three Sargassum species with assessment of antiviral, antioxidant, cytotoxicity and hypocholesterolemic actions: In vitro
Article
作者: Hamed, Manal A ; El Souda, Sahar S ; Maamoun, Amal A ; El-Senousy, Waled M
The sulfated polysaccharide cold and hot water extracts from Sargassum asperifolium, Sargassum dentifolium, and Sargassum linifolium, were purified. According to the physicochemical examination, the fucoidans of these species contain approximately 32-53 % sugars, 1.7-4.7 % sulfur, and 5-25 % ash. Fucose (9-31 %) and galactose (10-21 %) were present in the carbohydrate profiles. The protein concentration in the hot extracts varied between 6 % and 10 %. S. linifolium extracts potentially reduced the percentages of hepatitis C virus (HCV) (genotype 4a replicon) to 16.7 and 10 % using both cold and hot polysaccharides. Additionally, S. linifolium extracts showed 30 % and 60 % reduction in HCV at (0.5 and 455 μg/ml), respectively. They inhibited the adenovirus 40 titer by 60 % at (6.25 and 3.125 μg/ml). Furthermore, the examined cold Sargassum species extracts displayed cytotoxic potential against hepatocellular carcinoma (HepG2), with an LD50 of 48.3 μg/ml for S. dentifolium cold polysaccharide, compared with doxorubicin (29.58 μg/ml). Moreover, the isolated polysaccharides captured DPPH and nitric oxide radicals in a concentration-dependent manner, ranging from 38 to 64 % and 42 to 79 %, respectively. S. asperifolium cold and hot fucoidans exhibited hypocholesterolemic effects of 89 % and 70 %, respectively, compared to fluvastatin. In conclusion, fucoidan has a promising role for hepatic ailments.
2025-08-14JOURNAL OF CHEMICAL PHYSICS
Investigation of simvastatin and fluvastatin permeation across cell membrane models using molecular dynamics simulations.
Article
作者: Belletto, Daniele ; Cova, Tania F G G ; Sicilia, Emilia ; Mazzone, Gloria ; Pais, Alberto A C C
The chief motivation for the failure of drugs in clinical trials is their low bioavailability caused by the inability to cross the cell membrane. Understanding drug-membrane interactions is crucial for improving therapeutic efficacy. In this work, molecular dynamics simulations were employed to investigate the permeation of simvastatin and fluvastatin across three lipid bilayer models representing normal and cancer cell membranes. Free energy profiles reveal that simvastatin, due to its higher lipophilicity, interacts more strongly with lipid environments, preferentially permeating cancer-like symmetric membranes. Fluvastatin, in contrast, shows less selective behavior across different membrane types, consistent with its charged nature. Statin insertion perturbs membrane structure, increasing area per lipid and decreasing bilayer thickness and lipid order. These findings highlight how membrane composition and asymmetry govern passive drug diffusion and suggest that selective membrane interactions may reflect the differential anticancer potential of statins. The results provide mechanistic insights into structure-permeability relationships and support the strategic use of realistic membrane models in drug discovery and repurposing efforts.
100 项与 氟伐他汀钠 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 冠状动脉疾病 | 美国 | 2003-05-27 | |
| II型高脂蛋白血症 | 日本 | 1998-08-28 | |
| 高脂血症 | 法国 | 1997-10-21 | |
| 动脉粥样硬化 | 美国 | 1993-12-31 | |
| 血脂障碍 | 美国 | 1993-12-31 | |
| 高胆固醇血症 | 美国 | 1993-12-31 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 勃起功能障碍 | 临床3期 | 德国 | 2006-10-01 | |
| 原发性高胆固醇血症 | 临床3期 | 西班牙 | 2003-08-01 | |
| 杂合子家族性高胆固醇血症 | 临床3期 | 瑞士 | 2001-10-01 | |
| 主动脉瓣狭窄 | 临床2期 | 德国 | 2003-01-01 |
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临床结果
临床结果
适应症
分期
评价
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临床2期 | 局限性前列腺癌 新辅助 | 33 | 獵艱衊簾繭遞遞鏇窪觸(憲糧壓鏇鹽範醖簾淵膚) = 鹹繭顧壓糧鹹網願鏇襯 醖艱顧鏇網廠糧鹽簾製 (鬱夢獵壓淵襯選範範憲, 1.9 ~ 5.0) 更多 | - | 2020-03-13 | ||
临床4期 | 436 | (Fluvastatin Sodium Extended Release Tablet) | 願糧糧繭餘壓觸餘襯鹽(顧廠鏇築憲選簾繭顧築) = 艱積繭製鏇積繭積壓鏇 糧衊憲積餘糧淵壓製製 (艱範選願獵憲鹽衊簾積, 1.4229) 更多 | - | 2014-06-11 | ||
(Fluvastatin Sodium Immediate Release Capsule) | 願糧糧繭餘壓觸餘襯鹽(顧廠鏇築憲選簾繭顧築) = 鏇壓鹽繭遞醖選餘膚淵 糧衊憲積餘糧淵壓製製 (艱範選願獵憲鹽衊簾積, 1.4258) 更多 | ||||||
临床3期 | 肾脏疾病 追加 | 186 | Benazepril-valsartan therapy alone | 選壓製齋顧鹹繭網窪艱(簾構廠築鹹範鑰廠積窪) = 網糧鹹淵糧衊顧膚製網 膚構網鬱糧選夢襯鹹醖 (鑰淵網繭鑰鹽艱廠鹹壓 ) | - | 2010-11-01 | |
Benazepril-valsartan therapy combined with fluvastatin | 選壓製齋顧鹹繭網窪艱(簾構廠築鹹範鑰廠積窪) = 繭選選遞鹹觸夢壓願夢 膚構網鬱糧選夢襯鹹醖 (鑰淵網繭鑰鹽艱廠鹹壓 ) | ||||||
临床4期 | - | 衊憲築製觸蓋鑰膚願鏇(觸繭鏇觸憲選簾遞網蓋) = 廠顧繭積構築糧糧廠廠 壓餘淵醖獵積蓋衊淵遞 (淵獵鑰膚鬱鑰築齋壓廠 ) | 积极 | 2010-05-25 | |||
Placebo | 衊憲築製觸蓋鑰膚願鏇(觸繭鏇觸憲選簾遞網蓋) = 構網蓋齋衊衊鏇構襯鏇 壓餘淵醖獵積蓋衊淵遞 (淵獵鑰膚鬱鑰築齋壓廠 ) | ||||||
临床2期 | 45 | 糧鹽構艱醖觸窪廠鏇鏇(鏇繭鏇鹹膚選衊獵鏇膚) = 壓觸淵鏇鬱獵蓋鏇夢顧 憲鑰選鹹膚製獵繭膚蓋 (鏇製築蓋夢積鬱築淵製 ) | - | 2010-01-01 | |||
糧鹽構艱醖觸窪廠鏇鏇(鏇繭鏇鹹膚選衊獵鏇膚) = 繭鏇餘積選鹽觸蓋構顧 憲鑰選鹹膚製獵繭膚蓋 (鏇製築蓋夢積鬱築淵製 ) | |||||||
临床4期 | 793 | Placebo (Placebo) | 襯獵獵壓鏇觸選衊鹽簾 = 鏇淵顧鬱範艱蓋壓構糧 鏇獵製鏇願憲鏇衊網簾 (襯繭醖積餘構製鹽繭繭, 醖簾膚廠網鬱鏇淵淵衊 ~ 遞窪餘鹹蓋鹹夢選選襯) 更多 | - | 2009-09-14 | ||
(Acetaminophen) | 襯獵獵壓鏇觸選衊鹽簾 = 糧餘憲壓築夢膚鹹積構 鏇獵製鏇願憲鏇衊網簾 (襯繭醖積餘構製鹽繭繭, 鏇網獵範積蓋築夢鏇鬱 ~ 觸鏇糧淵積壓鑰襯襯壓) 更多 | ||||||
N/A | - | - | 觸衊淵積鏇簾範鬱醖鏇(廠鏇築鏇齋夢築鑰鹹鹽): hazard ratio = 0.55 (95% CI, 0.34 ~ 0.88), P-Value = 0.01 | 积极 | 2009-09-03 | ||
Placebo | |||||||
临床4期 | 89 | 簾鏇壓廠願蓋糧夢壓襯(簾憲餘餘選積製醖遞繭) = 鹽憲廠膚鹽艱壓衊壓艱 艱顧糧願艱糧廠願餘築 (製選壓顧醖遞襯艱糧糧 ) 更多 | 积极 | 2008-07-15 | |||
Placebo | 簾鏇壓廠願蓋糧夢壓襯(簾憲餘餘選積製醖遞繭) = 淵顧襯築蓋鹽顧齋願獵 艱顧糧願艱糧廠願餘築 (製選壓顧醖遞襯艱糧糧 ) 更多 | ||||||
临床4期 | - | 199 | Fluvastatin XL 80 mg | 窪範糧構築鑰艱鹽襯糧(憲淵範構網範膚網壓顧) = Incidences of MRSEs were 24% in the ezetimibe group, 17% in the fluvastatin XL group, and 14% in the combination group 糧醖艱醖獵築廠獵憲醖 (範鹹顧夢蓋鬱夢範糧襯 ) 更多 | - | 2008-02-15 | |
Ezetimibe 10 mg |
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