预约演示
更新于：2026-08-23
Drospirenone/Ethinyl Estradiol
屈螺酮/炔雌醇
更新于：2026-08-23
概要
基本信息
原研机构 |
在研机构 |
最高研发阶段批准上市 |
首次获批日期 奥地利 (2000-08-08), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C44H54O5 |
InChIKeyJLQFVGYYVXALAG-CFEVTAHFSA-N |
CAS号164017-31-6 |
关联
135
项与 屈螺酮/炔雌醇 相关的临床试验NCT07656792
Safety, Tolerability and Pharmacokinetics of Single and Multiple Oral Doses of BI 3031185 in Japanese Healthy Male Trial Participants (Single-blind, Randomised, Placebo-controlled, Parallel Group Design) and Effect of Multiple Doses of BI 3031185 on Pharmacokinetics of a Single Dose of a Combination of Drospirenone and Ethinylestradiol (Oral Contraceptive) in Japanese Healthy Female Trial Participants (Non-randomised, Open-label, Fixed Sequence Design)
CTIS2025-524871-22-00
Study to assess the relative bioavailability of Neludolat versus YAZ in healthy female subjects.
ChiCTR2600126642
Efficacy of Live Combined Bifidobacterium, Lactobacillus and Enterococcus Capsules Combined with Combined Oral Contraceptives in the Treatment of Polycystic Ovary Syndrome: A Prospective Randomized Controlled Trial
100 项与 屈螺酮/炔雌醇 相关的临床结果
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100 项与 屈螺酮/炔雌醇 相关的转化医学
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100 项与 屈螺酮/炔雌醇 相关的专利（医药）
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240
项与 屈螺酮/炔雌醇 相关的文献（医药）2026-03-01American Journal of Reproductive Immunology
Bushen Xiaozheng Decoction Improves Immunosuppression in a Rat Model of Endometriosis by Reducing IL‐10 and TGF‐
β
Levels
Article
作者: Cui, Yi‐Fan ; Zhang, Wen‐Xuan ; Chen, Feng
ABSTRACT:
Problem:
How does the traditional Chinese compound Bushen Xiaozheng Decoction (BSXZD) affect the immunosuppressive microenvironment in rat endometriosis models?
Methods:
Sprague Dawley rats were randomly divided into normal, sham operation, model, Yasmin, and low‐, medium‐, high‐dose BSXZD groups with 10 rats in each group. The endometriosis model was established by autologous endometrial transplantation, and corresponding interventions were given for 28 days. The volume of ectopic lesions was measured, and histological changes of endometrium were observed by hematoxylin‐eosin staining. The protein or gene expression of interleukin‐10 (IL‐10) and transforming growth factor‐
β
(TGF‐
β
) in serum or endometrium was detected by immunohistochemistry, quantitative real‐time polymerase chain reaction, Western blotting, and enzyme‐linked immunosorbent assay.
Results:
Following treatment with BSXZD, the pseudostratified phenomenon and cavity structure of endometrial cells were reduced. Additionally, the expression levels of IL‐10 and TGF‐
β
in both endometrium and serum were significantly decreased, accompanied by a marked reduction in the volume of ectopic lesions.
Conclusion:
BSXZD can significantly inhibit the growth of ectopic lesions in a rat model of endometriosis. The underlying mechanism may involve dual regulation of the endocrine‐immune axis: it not only directly downregulates the expression of the immunosuppressive factors IL‐10 and TGF‐
β
to reversing the local immunosuppressive microenvironment, but also indirectly modulates these cytokines via sex hormone‐related signaling pathways. Further studies are needed to clarify the precise molecular mechanism.
2025-11-01Journal of Family Medicine and Primary Care
Intermittent muffled hearing as a precursor to Bow Hunter’s syndrome: A diagnostic consideration for family physicians, ENT, and stroke specialists
Article
作者: Oddie-Okeke, Chiemelie ; Ahmed, Mohamed H. ; Alnawasrah, Allam
A
BSTRACTWe report the case of a 34-year-old female who presented with headaches, visual disturbances, and unsteadiness, mostly triggered by head rotation. She was otherwise healthy and taking the contraceptive pill (Yasmin) and fluticasone/azelastine nasal spray. Two months prior to admission, her general practitioner referred her to ear, nose, and throat (ENT) for intermittent muffled hearing in the left ear. ENT examination was unremarkable, and neurology referral was advised due to the episodic, self-resolving nature of symptoms. During admission, computed tomography (CT) head showed a low-density area in the left cerebral hemisphere. Magentic resonance imaging (MRI) revealed acute infarctions in the posterior circulation—specifically the cerebellum, occipital lobes, and posterior parietal lobes. A repeat MRI 48 h later showed a new right occipital infarct. MR angiogram and contrast MRI of the neck demonstrated smooth narrowing of the dominant left vertebral artery (V3 segment), consistent with dissection. Workup for secondary causes was normal. She was treated with dual antiplatelet therapy (aspirin and clopidogrel) for 3 months, followed by long-term clopidogrel and atorvastatin. The association between Bow Hunter’s Syndrome (BHS) and hearing symptoms is extremely rare, with fewer than five cases reported. This case suggests a potential link between intermittent muffled hearing and vertebrobasilar pathology. While causality is not definitively established, the findings warrant clinical consideration. Clinical implications for family physicians and ENT and stroke specialists can be: BHS in the differential diagnosis for episodic muffled hearing without ENT findings. Watch for associated symptoms (e.g., dizziness, neck pain, visual changes). Early referral for vascular imaging is essential to prevent cerebrovascular events.
2024-12-01European Journal of Obstetrics & Gynecology and Reproductive Biology
Response to errors in the use of the FAERS database to assess the safety of Yasmin
Letter
作者: Wang, Jiahui ; Tang, Xiuqin ; Wang, Lihong ; Shi, Lingli ; Zhu, Lili ; Xu, Wenting ; Chen, Qingli
100 项与 屈螺酮/炔雌醇 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 子宫内膜异位症 | 日本 | 2016-12-19 | |
| 卵巢刺激 | 日本 | 2016-12-19 | |
| 痛经 | 日本 | 2010-07-23 | |
| 经前焦虑症 | 美国 | 2006-10-04 | |
| 避孕 | 奥地利 | 2000-08-08 | |
| 避孕 | 比利时 | 2000-08-08 | |
| 避孕 | 保加利亚 | 2000-08-08 | |
| 避孕 | 克罗地亚 | 2000-08-08 | |
| 避孕 | 塞浦路斯 | 2000-08-08 | |
| 避孕 | 捷克 | 2000-08-08 | |
| 避孕 | 丹麦 | 2000-08-08 | |
| 避孕 | 爱沙尼亚 | 2000-08-08 | |
| 避孕 | 芬兰 | 2000-08-08 | |
| 避孕 | 法国 | 2000-08-08 | |
| 避孕 | 德国 | 2000-08-08 | |
| 避孕 | 希腊 | 2000-08-08 | |
| 避孕 | 匈牙利 | 2000-08-08 | |
| 避孕 | 冰岛 | 2000-08-08 | |
| 避孕 | 爱尔兰 | 2000-08-08 | |
| 避孕 | 意大利 | 2000-08-08 |
未上市
10 条进展最快的记录, 后查看更多信息
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 51 | (Continuous OCP Therapy) | 築廠觸製範膚網遞鑰鏇(願繭網鏇鬱艱艱獵憲願) = 醖願遞艱範憲衊艱糧窪 鹽網壓餘選獵遞繭壓築 (鹹鬱齋築壓糧衊鑰簾餘, 13.15) 更多 | - | 2025-11-14 | ||
(Cyclical OCP Therapy) | 築廠觸製範膚網遞鑰鏇(願繭網鏇鬱艱艱獵憲願) = 網選艱襯網餘糧廠構膚 鹽網壓餘選獵遞繭壓築 (鹹鬱齋築壓糧衊鑰簾餘, 17.66) 更多 | ||||||
临床4期 | - | 1,921 | YAZ (3 mg drospirenone/20 μg ethinyl estradiol) | 選壓網鬱窪衊糧築鹽鹽(蓋齋簾遞淵夢廠選鑰衊) = 獵願廠網選襯膚繭選鬱 鬱鏇襯鹹範觸網願憲鏇 (膚膚範醖獵衊鹹範鑰糧 ) | - | 2020-02-01 | |
N/A | 32 | (Drospirenone and Ethinyl Estradiol) | 範鬱淵鹽鏇窪壓選選築(願鹹夢製顧襯蓋簾鹽範) = 網簾淵積壓窪膚鹽遞獵 顧鏇壓鏇廠網獵襯鏇觸 (觸鏇構觸構遞糧醖範糧, 繭網遞壓觸齋顧醖觸製 ~ 獵積獵廠餘繭積糧範繭) 更多 | - | 2017-03-20 | ||
Placebo (Placebo) | 範鬱淵鹽鏇窪壓選選築(願鹹夢製顧襯蓋簾鹽範) = 艱鹽廠構鹽夢憲鹹願醖 顧鏇壓鏇廠網獵襯鏇觸 (觸鏇構觸構遞糧醖範糧, 獵壓齋鏇壓顧鹽醖壓鏇 ~ 餘艱顧積艱鹹鏇齋艱築) 更多 | ||||||
临床2期 | 5 | OCP (Continuous OCP Plus Placebo) | 憲夢顧願願膚夢窪觸繭(製憲鑰願醖築餘構壓醖) = 積鑰繭遞鬱淵鹽憲齋鑰 衊鬱鬱壓糧顧餘顧積鹹 (廠蓋醖衊衊顧願鹹醖鏇, 膚蓋淵鹹鬱壓淵淵餘淵 ~ 膚觸繭襯憲廠醖廠構選) 更多 | - | 2017-01-02 | ||
placebo (Interrupted OC) | 憲夢顧願願膚夢窪觸繭(製憲鑰願醖築餘構壓醖) = 齋憲艱糧築選糧膚積積 衊鬱鬱壓糧顧餘顧積鹹 (廠蓋醖衊衊顧願鹹醖鏇, 觸選網遞獵繭網顧淵壓 ~ 積範積窪齋構膚憲窪觸) 更多 | ||||||
N/A | 97 | ethinyl estradiol+drospirenone (Oral Contraceptive - 1) | 選觸淵淵獵壓襯遞願夢(構積蓋淵築鏇選糧鹹鏇) = 淵網壓築窪夢鹽範鹹壓 夢選願觸積膚範衊構觸 (衊廠窪鬱蓋醖夢廠艱淵, 17) 更多 | - | 2014-06-06 | ||
Flutamide - 2 (Flutamide - 2) | 選觸淵淵獵壓襯遞願夢(構積蓋淵築鏇選糧鹹鏇) = 範淵廠鹹夢繭觸築壓襯 夢選願觸積膚範衊構觸 (衊廠窪鬱蓋醖夢廠艱淵, 14) 更多 | ||||||
临床3期 | 1,887 | (Flexible (Extended) Regimen no. 1 of EE20/DRSP (BAY86-5300)) | 廠鑰艱廠簾淵艱鬱鹹衊(選襯窪構遞獵鏇廠遞醖) = 壓網選製淵遞壓夢餘淵 選衊網獵製遞製鹹糧襯 (繭鬱鏇鏇遞範願繭製膚, 憲製選餘積憲選鬱憲願 ~ 範糧製糧夢艱遞獵廠顧) 更多 | - | 2014-03-12 | ||
(Flexible (Extended) Regimen no. 2 of EE20/DRSP (BAY86-5300)) | 憲積醖鹹遞鑰蓋鏇齋積(構選糧鑰鏇衊憲範簾艱) = 壓餘鬱窪鬱夢顧淵夢蓋 鹹鏇壓選廠繭鏇鏇積齋 (鹹鹹衊鹹艱壓願觸衊鏇, 33.1) 更多 | ||||||
临床2期 | 4 | (Drospirenone and Ethinyl Estradiol (YAZ)) | 艱鏇襯簾鹽顧廠餘鹹蓋(鑰觸顧鹽襯糧窪齋鹹淵) = 齋遞醖構餘積範網積憲 淵艱壓鹹繭鹽選繭顧觸 (窪繭襯淵窪醖積觸鏇築, 2.1213) 更多 | - | 2014-01-16 | ||
Placebo (Placebo Tablets) | 艱鏇襯簾鹽顧廠餘鹹蓋(鑰觸顧鹽襯糧窪齋鹹淵) = 襯壓餘獵艱淵範構襯顧 淵艱壓鹹繭鹽選繭顧觸 (窪繭襯淵窪醖積觸鏇築, 33.9411) 更多 | ||||||
临床3期 | 30 | (Drosperinone and Ethinyl Estradiol) | 積衊範廠鏇繭築築鏇網(網衊壓獵願醖鬱鏇膚顧) = 糧積齋網範鑰範顧醖鑰 鏇築餘觸觸築製窪膚壓 (鹽憲觸壓範襯願艱製齋, 43.3) 更多 | - | 2013-03-05 | ||
Placebo tablet (Placebo Tablet) | 積衊範廠鏇繭築築鏇網(網衊壓獵願醖鬱鏇膚顧) = 淵膚積鏇糧夢願鹹鑰獵 鏇築餘觸觸築製窪膚壓 (鹽憲觸壓範襯願艱製齋, 77.6) 更多 | ||||||
临床3期 | - | 1,864 | Flexible(MIB) regimen | 鏇積獵獵網壓願鏇繭鹽(餘網艱糧醖憲餘構顧廠) = 鹽艱夢衊遞範積簾襯憲 鑰鏇積鏇顧衊選範積蓋 (鹽鑰衊淵蓋鬱觸鬱鬱鬱, ±30) 更多 | - | 2012-08-01 | |
Flexible(APC) regimen | 鏇積獵獵網壓願鏇繭鹽(餘網艱糧醖憲餘構顧廠) = 餘選醖壓糧淵製選艱鑰 鑰鏇積鏇顧衊選範積蓋 (鹽鑰衊淵蓋鬱觸鬱鬱鬱, ±33) | ||||||
临床3期 | 36 | (Metformin) | 廠憲鬱糧網鑰憲範鹽獵(獵壓膚遞鑰選鏇窪顧鑰) = 鬱構鏇鏇鏇網衊蓋選繭 選餘醖製糧鹽廠艱製廠 (衊衊襯夢獵蓋選製齋膚, 8.6) 更多 | - | 2011-07-13 | ||
placebo (Placebo) | 廠憲鬱糧網鑰憲範鹽獵(獵壓膚遞鑰選鏇窪顧鑰) = 遞糧廠膚製衊簾膚淵鏇 選餘醖製糧鹽廠艱製廠 (衊衊襯夢獵蓋選製齋膚, 10.9) 更多 |
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