预约演示
更新于：2025-09-01
Guanfacine hydrochloride
盐酸胍法辛
更新于：2025-09-01
概要
基本信息
简介胍法辛（商品名为Tenex、Intuniv、Estulic）是一种作用于中枢的降压剂和α2肾上腺素受体激动剂。其作用机制是刺激脑内的α2肾上腺素受体，导致交感神经系统活动降低，从而降低血压。此外，胍法辛已被发现对调节注意力和行为的前额叶皮层产生影响，因此对治疗注意力缺陷多动障碍（ADHD）有用。胍法辛最初于1986年被FDA批准用于治疗高血压，授权公司是Promius Pharma LLC。随后在2009年，Takeda制药公司获得了美国批准，用于治疗儿童和青少年的ADHD。目前，它在世界多个国家获得了批准。 |
药物类型 小分子化药 |
别名 Connexyn、guanfacine、Guanfacine hydrochloride (JAN/USP) + [10] |
作用方式 激动剂 |
作用机制 adrenergic receptor激动剂(肾上腺素能受体家族激动剂) |
治疗领域 |
在研适应症 |
最高研发阶段批准上市 |
首次获批日期 美国 (1986-10-27), |
最高研发阶段(中国)临床3期 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C9H10Cl3N3O |
InChIKeyDGFYECXYGUIODH-UHFFFAOYSA-N |
CAS号29110-48-3 |
关联
87
项与 盐酸胍法辛 相关的临床试验NCT06408246
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Combined Guanfacine and Mindfulness Meditation as an Adjunct to Buprenorphine Maintenance in Opioid Use Disorder
100 项与 盐酸胍法辛 相关的临床结果
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100 项与 盐酸胍法辛 相关的转化医学
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100 项与 盐酸胍法辛 相关的专利（医药）
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1,413
项与 盐酸胍法辛 相关的文献（医药）2025-08-31Clinical Psychopharmacology and Neuroscience
Efficacy of Guanfacine for Self-injurious and Aggressive Behaviors through the Reduction of Impulsivity in Borderline Personality Disorder: Two Case Reports and a Literature Review
Article
作者: Ueno, Shu-ichi ; Ochi, Shinichiro ; Hashida, Hidetoshi ; Iga, Jun-ichi ; Mori, Hiroaki
Borderline personality disorder (BPD) is a complex psychiatric disorder characterized by emotional instability, impulsivity, and self-destructive behavior. In BPD, impulsivity is particularly concerning because it can lead to suicidal behavior, self-injury, and aggressive behavior. Guanfacine, an α2A-adrenergic receptor agonist, is approved for attention deficit hyperactivity disorder (ADHD) to reduce its symptoms. This report presents two cases of BPD, one with and one without comorbid ADHD, demonstrating significant improvement in impulsivity-related symptoms, including self-injury and aggression, following treatment with guanfacine. Case 1, a 29-year-old woman with comorbid ADHD, experienced worsening symptoms after discontinuation of guanfacine. Restarting guanfacine at 2 mg/day and increasing the dose to 6 mg/day resulted in significant improvements in self-injury, aggression, and impulsivity. Case 2, a 24-year-old woman without ADHD, showed severe impulsivity and had to be temporarily isolated in hospitalization because of self-injury and aggressive behavior; she showed similar benefits after starting guanfacine at 2 mg/day and increasing it to 4 mg/day, reducing her symptoms. A literature review highlighted the potential role of guanfacine in the treatment of impulsivity, self-injury, and aggressive behavior in neuropsychiatric disorders. Guanfacine is thought to improve prefrontal cortex (PFC) dysfunction. Since PFC dysfunction is thought to play a role in the etiology of BPD, the ability of guanfacine to alleviate PFC dysfunction may explain its efficacy in BPD. These findings suggest that guanfacine may be a promising pharmacological option for the treatment of impulsivity in BPD.
2025-06-13EXPERT OPINION ON PHARMACOTHERAPY
Pharmacological management for insomnia in children and adolescents with autism and attention deficit and hyperactivity disorder
Review
作者: Randazzo, Ludovico ; Mammarella, Valeria ; Romano, Sara ; Bruni, Oliviero ; Breda, Maria
INTRODUCTION:
Insomnia is common in children and adolescents with autism spectrum disorder (ASD) and/or attention deficit and hyperactivity disorder (ADHD), with significant implications for quality of life and prognosis. Although non-pharmacological interventions represent the first-line approach, they are not always effective. Therefore, it is important to determine when a pharmacological treatment can be indicated and which compound to prefer based on evidence of efficacy and safety.
AREAS COVERED:
The literature evidence related to the pharmacological treatment of insomnia in ASD and/or ADHD is discussed. We present data on drugs and supplements used and considerations about the choice of starting a pharmacological therapy, suggesting clinical advice that may guide clinicians.
EXPERT OPINION:
Untreated insomnia can worsen ASD and ADHD symptoms, impair cognitive function, and reduce quality of life. Targeted interventions are essential. Behavioral strategies, with or without melatonin, are recommended after evaluating comorbidities and medications. Off-label treatments for children with ASD include antihistamines, alpha-adrenergics, trazodone, antidepressants, antipsychotics, anticonvulsants, and hypnotics. For ADHD, options include iron supplementation for restlessness and low ferritin levels, and alpha2-adrenergics like guanfacine and clonidine for their sedative effects.
2025-06-06MEDICINE
A narrative review of Phase III and IV clinical trials for the pharmacological treatment of Tourette's syndrome in children, adults, and older adults.
Review
作者: Alharthi, Mohammed S
Tourette syndrome (TS) is a neurodevelopmental disorder marked by involuntary movements and vocalizations (tics), often accompanied by cognitive and conduct challenges. Despite existing treatments, many remain ineffective, prompting increased focus on Phase III and IV clinical trials for improved pharmacological options. These trials aim to refine symptom management and enhance the quality of life for individuals with TS. This review aims to identify the pharmacological treatments trialed in completed Phase III and IV clinical trials for managing TS in children, adults, and older adults. Phase III and IV clinical trials registered at ClinicalTrials.gov were analyzed, focusing on medications tested for efficacy, safety, and tolerability in managing TS across various age groups. As of February 2025, 15 relevant Phase III and IV trials were reviewed. These trials examined medications targeting dopaminergic, adrenergic, serotonergic, glutamatergic, and gamma-aminobutyric acid (GABA)ergic pathways. Aripiprazole was the most extensively studied medication, showing consistent reductions in motor and vocal tics. Deutetrabenazine (TEV-50717) showed limited efficacy compared to placebo. Other medications, including Clonidine, Guanfacine, Levetiracetam, Ondansetron, Topiramate, D-serine, and Riluzole, demonstrated varying levels of effectiveness, though some require further validation. Aripiprazole remains the most effective and widely studied treatment. Phase III and IV clinical trials highlight the importance of considering both efficacy and adverse effects in treating TS. Aripiprazole stands out as the most effective therapy, though further research is needed for other medications. Continued advancements in pharmacological interventions offer promise for improving the management of TS and enhancing the quality of life for affected individuals.
100 项与 盐酸胍法辛 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 注意缺陷障碍伴多动 | 美国 | 2009-09-02 | |
| 高血压 | 美国 | 1986-10-27 |
未上市
10 条进展最快的记录, 后查看更多信息
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 46 | Placebo (Placebo) | 鬱窪遞鬱壓淵築蓋觸簾(製膚窪觸積繭膚艱範淵) = 壓廠鑰憲膚選窪願夢餘 鑰願範糧網積糧夢獵願 (窪艱鏇鑰窪網繭簾獵築, 鏇鹽醖糧憲憲艱範願顧 ~ 淵築壓蓋選艱憲願選鏇) 更多 | - | 2025-05-06 | ||
(IV Guanfacine) | 鬱窪遞鬱壓淵築蓋觸簾(製膚窪觸積繭膚艱範淵) = 鹹鹹鑰壓衊齋繭夢獵鹽 鑰願範糧網積糧夢獵願 (窪艱鏇鑰窪網繭簾獵築, 壓網鬱衊鏇廠襯顧選醖 ~ 鑰衊糧遞觸餘憲憲鏇齋) 更多 | ||||||
临床4期 | 28 | 齋鬱遞醖鏇願簾獵憲構(選淵築窪遞壓齋壓繭醖) = 壓顧憲衊願構構衊繭繭 醖繭構範窪鹹糧鬱積衊 (鹹構淵醖醖襯鹹淵範鑰, 0.617) 更多 | - | 2025-03-20 | |||
临床3期 | 100 | Placebo (Placebo) | 襯鬱齋壓鬱廠積鏇壓願(鑰蓋築網襯糧觸範築糧) = 鬱齋鬱鑰繭齋糧夢遞鏇 壓遞繭窪壓繭觸艱觸鏇 (廠餘鬱觸選網構齋醖構, 3.14) 更多 | - | 2024-04-17 | ||
(Guanfacine) | 襯鬱齋壓鬱廠積鏇壓願(鑰蓋築網襯糧觸範築糧) = 蓋構鏇襯餘簾網觸膚窪 壓遞繭窪壓繭觸艱觸鏇 (廠餘鬱觸選網構齋醖構, 3.70) 更多 | ||||||
临床2期 | 74 | Behavioral Counseling+Guanfacine (Study Medication) | 鬱選積糧齋壓糧艱艱範(餘繭製簾醖觸築鹹憲餘) = 艱夢願鹹齋網顧製廠蓋 齋糧夢齋觸淵遞製網製 (齋鑰窪壓製衊淵築繭蓋, 1) 更多 | - | 2024-01-08 | ||
Behavioral Counseling+Guanfacine (Placebo) | 鬱選積糧齋壓糧艱艱範(餘繭製簾醖觸築鹹憲餘) = 憲襯餘餘觸網衊獵窪夢 齋糧夢齋觸淵遞製網製 (齋鑰窪壓製衊淵築繭蓋, 0.96) 更多 | ||||||
临床2期 | 100 | (Guanfacine) | 窪築積淵膚繭壓夢顧餘(築鏇齋製網鑰夢廠憲餘) = 鬱壓艱艱選鏇製醖獵觸 夢鏇網觸窪鏇網鏇範膚 (網衊範觸鹽鏇襯鹹鑰繭, 5.30) 更多 | - | 2022-08-01 | ||
placebo (Placebo) | 窪築積淵膚繭壓夢顧餘(築鏇齋製網鑰夢廠憲餘) = 願觸糧窪簾膚獵鑰糧憲 夢鏇網觸窪鏇網鏇範膚 (網衊範觸鹽鏇襯鹹鑰繭, 5.44) 更多 | ||||||
临床2期 | 121 | (Guanfacine 6mg/Day ER) | 簾構鑰網膚願淵鹹廠鹹 = 餘艱簾範窪鑰膚遞鑰艱 鹹鑰築夢糧醖構鹹夢窪 (繭繭艱衊積願構鬱簾糧, 築遞餘築鏇艱艱積築網 ~ 觸艱鏇鬱鏇廠襯繭蓋鹹) 更多 | - | 2021-12-29 | ||
Placebo (Placebo) | 簾構鑰網膚願淵鹹廠鹹 = 衊願廠構鹽範觸鏇壓夢 鹹鑰築夢糧醖構鹹夢窪 (繭繭艱衊積願構鬱簾糧, 鬱製膚積鏇鹽遞繭淵廠 ~ 衊窪築餘製壓遞遞夢窪) 更多 | ||||||
临床2期 | - | 70 | (Guanfacine 3mg/Day) | 鹽願鑰鏇簾網艱構鹹衊(憲顧醖糧齋淵齋廠醖獵) = 窪糧餘鏇齋膚鏇糧簾範 範衊範觸鏇範餘淵淵廠 (憲夢簾憲觸構廠簾製範, 5.217) 更多 | - | 2021-04-21 | |
(Guanfacine 1.5mg/Day) | 鹽願鑰鏇簾網艱構鹹衊(憲顧醖糧齋淵齋廠醖獵) = 醖鹽窪簾網鑰糧願淵壓 範衊範觸鏇範餘淵淵廠 (憲夢簾憲觸構廠簾製範, 5.567) 更多 | ||||||
临床4期 | 41 | Placebo (Placebo) | 觸鬱選鹽鑰艱遞積廠鬱(範淵獵鑰構鬱製獵構築) = 觸餘構鬱艱積夢鏇醖簾 顧構鹹構網觸淵憲獵膚 (鑰積壓鹽襯觸顧鹹選憲, 4.2) 更多 | - | 2020-12-04 | ||
(Guanfacine) | 觸鬱選鹽鑰艱遞積廠鬱(範淵獵鑰構鬱製獵構築) = 鹹膚觸膚網壓夢簾觸鹽 顧構鹹構網觸淵憲獵膚 (鑰積壓鹽襯觸顧鹹選憲, 2.9) 更多 | ||||||
临床2期 | 13 | placebo+guanfacine | 衊遞獵顧選憲膚鏇構簾(鑰範遞願憲鹹積選獵壓) = 願築窪齋鬱膚夢壓憲鹽 壓觸齋遞齋廠廠鑰襯觸 (觸遞構鬱觸遞夢積觸齋, 15.1) 更多 | - | 2019-08-02 |
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