A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Clinical Trial and Open-Label Extension Study to Evaluate the Efficacy and Safety of Add-On Therapy With Empagliflozin for Patients With Inadequately Controlled Type 2 DiabetesMellitus in the Combination Treatment With Metformin and Alogliptin

Phase 3 study to assess the Efficacy and Safety of CT-L02-301 in Type 2 Diabetes Patients with Insufficient Glycemic Control with Metformin and Alogliptin Combination Therapy.

开始日期2025-07-18

申办/合作机构

Celltrion, Inc.

CTR20250730

/ CompletedN/A

苯甲酸阿格列汀片（25mg）在中国健康受试者中空腹给药条件下随机、开放、单剂量、两序列、两周期、双交叉生物等效性试验

主要研究目的：按有关生物等效性试验的规定，选择Takeda Pharmaceutical Company Limited为持证商的苯甲酸阿格列汀片（商品名：尼欣那，规格：25mg）为参比制剂，对石家庄四药有限公司生产并提供的受试制剂苯甲酸阿格列汀片（规格：25mg）进行空腹给药人体生物等效性试验，比较受试制剂中药物的吸收速度和吸收程度与参比制剂的差异是否在可接受的范围内，评价两种制剂在空腹给药条件下的生物等效性。次要研究目的：观察健康受试者口服受试制剂苯甲酸阿格列汀片（规格：25mg）和参比制剂苯甲酸阿格列汀片（商品名：尼欣那，规格：25mg）的安全性。

开始日期2025-03-24

申办/合作机构

石家庄四药有限公司

CTR20250729

/ CompletedN/A

苯甲酸阿格列汀片（25mg）在中国健康受试者中餐后给药条件下随机、开放、单剂量、两序列、两周期、双交叉生物等效性试验

主要研究目的：按有关生物等效性试验的规定，选择Takeda Pharmaceutical Company Limited为持证商的苯甲酸阿格列汀片（商品名：尼欣那，规格：25mg）为参比制剂，对石家庄四药有限公司生产并提供的受试制剂苯甲酸阿格列汀片（规格：25mg）进行餐后给药人体生物等效性试验，比较受试制剂中药物的吸收速度和吸收程度与参比制剂的差异是否在可接受的范围内，评价两种制剂在餐后给药条件下的生物等效性。次要研究目的：观察健康受试者口服受试制剂苯甲酸阿格列汀片（规格：25mg）和参比制剂苯甲酸阿格列汀片（商品名：尼欣那，规格：25mg）的安全性。

开始日期2025-03-23

申办/合作机构

石家庄四药有限公司

100 项与苯甲酸阿格列汀相关的临床结果

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100 项与苯甲酸阿格列汀相关的转化医学

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100 项与苯甲酸阿格列汀相关的专利（医药）

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705

项与苯甲酸阿格列汀相关的文献（医药）

2026-01-02·Expert Opinion On Drug Safety

Exploring SGLT-2 inhibitors and sarcopenia in FAERS: a post-marketing surveillance study

Article

作者: Tang, Guowen ; Yuan, Jie ; Ye, Yangli ; Kuai, Zheng ; Zhang, Xiaoyi ; Gao, Lihong

BACKGROUND:

The sodium-dependent glucose transporters 2 inhibitors (SGLT-2i) is associated with body weight loss but the composition of the losing weight remains unclear.

RESEARCH DESIGN AND METHODS:

Disproportionality analyses, including the reporting odds ratio (ROR), the proportional reporting ratio (PRR), the Bayesian confidence propagation neural network (BCPNN), and the multi- item gamma Poisson shrinker (MGPS) algorithms, were employed to quantify the signals of SGLT-2i-associated musculoskeletal and connective tissue disorders AEs.

RESULTS:

The search retrieved a total of 3,206 cases of musculoskeletal and connective tissue disorder-related AEs during the reporting period. This included 1,061 cases for Canagliflozin, 1,052 cases for Dapagliflozin, 1,074 cases for Empagliflozin, and 19 cases for Ertugliflozin. Fifteen preferred terms (PTs) with significant disproportionality were retained. No musculoskeletal and connective tissue system-related AE signals were reported for Ertugliflozin. We identified a risk of muscle necrosis with Canagliflozin use, a risk of sarcopenia with Dapagliflozin use, and a chance of muscle atrophy with Dapagliflozin and Empagliflozin prescriptions. Most cases occurred within the first month after SGLT-2i initiation, and AEs can persist beyond 360 days of use.

CONCLUSIONS:

Our study identified potential new musculoskeletal and connective tissue disorder-related AE signals associated with SGLT-2 inhibitors.

2026-01-01·JOURNAL OF DIABETES AND ITS COMPLICATIONS

Dipeptidyl peptidase-4 inhibitors and diabetic retinopathy in type 2 diabetes: A network meta-analysis of randomized clinical trials

Review

作者: Ortiz-Seller, Amparo ; Real, José Tomás ; Morcillo, Esteban ; Ortiz, José Luis

AIMS:

To update evidence on the relationship between dipeptidyl peptidase-4 (DPP-4) inhibitors and incident diabetic retinopathy (DR) in type 2 diabetes.

METHODS:

We searched Embase, PubMed, Web of Science, and ClinicalTrials.gov (to July 2025) for randomized controlled trials (RCTs) and pooled odds ratios (ORs) with 95 % credible intervals (CrIs) using a Bayesian network meta-analysis. Network meta-regression assessed estimated effect modification; a model-based network meta-analysis (MBNMAdose) evaluated dose-response. Evidence certainty was appraised with Confidence in Network Meta-Analysis (CINeMA).

RESULTS:

Forty-three trials (74,546 participants; 779 DR events) were analyzed. No DPP-4 inhibitor significantly changed the DR risk versus placebo (ORs ranged from 0.31 [omarigliptin] to 2.31 [saxagliptin]; all CrIs crossed 1.0). Rankings suggested omarigliptin as most favorable, alogliptin/linagliptin/sitagliptin intermediate, and saxagliptin/teneligliptin least favorable. Baseline DR incidence moderated treatment effects; other prespecified covariates were not significant. MBNMAdose showed no dose-response relationship for DR.

CONCLUSIONS:

Current randomized evidence indicates class-level neutrality of DPP-4 inhibitors on DR incidence, with no dose-response signal. Choice among gliptins may therefore be guided primarily by glycemic efficacy, safety, and participant characteristics rather than retinal risk.

2025-12-01·Journal of Pharmacy and Bioallied Sciences

Comparative Effect of SGLT2 Inhibitors and GLP-1 Agonists on Glycemic Control in Type 2 Diabetes Mellitus

Article

作者: Podder, Amrit ; Jani, Parth ; Singh, Saumya ; Deshpande, Amit Vasant ; Gupta, Sangeeta ; Rawat, Anurag ; Prakash, Ved

Introduction::

The goal of this study was to find out how SGLT2 inhibitors and GLP-1 receptor agonists help persons with Type 2 Diabetes Mellitus (T2DM) keep their blood sugar levels stable.

Methodology::

There were 120 people in the trial. They were randomly given either empagliflozin, Canagliflozin, Dapagliflozin, Ertugliflozin, Bexagliflozin, Sotagliflozin (an SGLT2 inhibitor) or liraglutide, Sitagliptin, Saxagliptin, Linagliptin, Alogliptin, Vildagliptin (n GLP-1 receptor agonist) to consume for 24 weeks. The major goal was to lower the levels of HbA1c. Some of the secondary outcomes included losing weight, markers of heart health, and adverse events.

Results::

Both treatments brought down HbA1c levels a lot, although GLP-1 agonists brought them down a little bit more. Both groups’ systolic blood pressure and LDL cholesterol levels improved, but the group that took GLP-1 agonists lost more weight. People who took SGLT2 inhibitors didn’t have as many stomach problems, whereas people who took GLP-1 agonists got nauseated and threw up.

Conclusion::

The study showed that both types of medicines do a decent job of keeping blood sugar levels steady. But GLP-1 agonists are better at helping people lose weight and keep their hearts healthy, so they are also a fantastic choice for people who have these problems. It’s crucial to consider what each patient needs and what could go wrong while establishing treatment plans for them.

177

项与苯甲酸阿格列汀相关的新闻（医药）

2026-01-25

·AIDD Pro

【第二百一十一期】AI+药物研发领域一周资讯

前言 AIDD Pro 根据国内外各大网站以及人工智能药物设计主流新闻网站及公众号，从 AIDD会议，重大科研进展、行业动态、最新报告发布等角度，分析挖掘了每周人工智能辅助药物设计领域所发生的、对领域技术发展产生重大推动作用的事件，旨在帮助 AIDD领域研究人员和业内人士及时追踪最新科研动态、洞察前沿热点。如果您觉得符合以上要求的内容我们有遗漏或者更好建议，欢迎后台留言。科研进展2026年1月23日【靶点】ACS Omega | 诺比莱汀通过靶向氧化应激、炎症和凋亡途径改善阿霉素诱导的肾毒性：体内和体外联合研究的见解2026年1月23日【蛋白质 - 配体相互作用】Anal. Chem. | 超越结合亲和力：利用时间分辨荧光共振能量转移对蛋白质 - 配体相互作用进行详细剖析2026年1月22日【虚拟筛选】J. Chem. Inf. Model. | CoDrug：一种基于文本驱动的分子虚拟筛选及多属性优化框架，通过多模态语言模型实现2026年1月22日【深度学习】J. Chem. Inf. Model. | DeepDBPI：基于深度学习模型和转换去噪特征的 DNA 结合蛋白识别器2026年1月21日【分子动力学模拟】ACS Omega | 用于识别新型二肽基肽酶-4 抑制剂的 GPU 加速虚拟筛选和分子动力学模拟2026年1月21日【逻辑门】Anal. Chem. | 一种基于与逻辑门的生物传感器，用于同时检测 SARS-CoV-2 核酸和核衣壳蛋白具体信息，请滑动下方文字 1.【靶点】多柔比星（DOX）作为一种化疗药物虽然效果显著，但会引发严重的肾毒性，从而限制了其临床应用。本研究旨在比较诺贝汀和山柰素对多柔比星诱导的大鼠急性肾损伤（AKI）的肾脏保护作用，同时与参考化合物水飞蓟素进行对比。多柔比星的使用显著增加了肾脏与体重的比率（p = 0.0053），提高了血清丙二醛（MDA）水平（11.49 ± 1.77 纳摩尔/毫升），并降低了血清白蛋白（ALB）水平（10.23 ± 1.84 毫克/毫升）。诺贝汀显著降低了MDA水平至8.12 ± 1.56 纳摩尔/毫升，并将ALB恢复至15.89 ± 1.31 毫克/毫升（p < 0.01），同时下调了CASP3、TNF-α 和 PARP1的表达。组织病理学分析表明，诺贝利丁对肾小管坏死、肾小球萎缩和间质炎症具有显著的防护作用，其损伤评分与假手术组相似。分子对接结果显示，水飞蓟素与诸如CASP3、TNF-α和HO-1 等靶点的结合亲和力最为有利；然而，其较差的药代动力学特性（TPSA = 155.14 Å2）限制了其全身疗效。相比之下，诺贝利丁表现出优越的口服吸收（TPSA < 90 Å2）和双重 CYP 抑制作用，从而在体内表现更佳。NRF2/HO-1 通路适度激活，尽管 mRNA 水平降低，但 HO-1 蛋白水平升高，表明存在转录后调控。总之，诺贝利丁显示出一致的多水平保护特性，对关键的凋亡和炎症标志物有显著调节作用，而所有化合物都提供了相当的生化和组织学益处。这些发现支持进一步开发诺贝利丁作为化疗环境中一种有前景的肾脏保护剂。链接网址：https://pubs.acs.org/doi/10.1021/acsomega.5c07049 DOI：https://doi.org/10.1021/acsomega.5c07049 2.【蛋白质 - 配体相互作用】发现新的 E3 连接酶配体，并对这些配体与连接酶之间关键的二元相互作用进行准确表征，对于合理设计新的 E3 连接酶配体以及扩展蛋白质切割靶向嵌合体具有重要意义。在此，我们开发了一种时间分辨的福斯特共振能量转移（TR-FRET）平台，用于对蛋白质-配体相互作用进行多参数分析，以获取传统基于亲和力的检测方法所无法揭示的先前隐匿的见解。该平台被用于研究从模型系统（HaloTag 和 VHL）到新型 E3 连接酶 CDC20 与 Apcin 的相互作用。通过光致发光衰减的多指数拟合，关键参数（不同的 FRET 子群体、它们的幅度、效率和距离）直接报告了蛋白质结合位点的占有率（或结合配体的分数）以及潜在的结合几何结构或分子定向的变化。热图可视化进一步将复杂的结合数据转化为直观的格式，为药物化学家提供了一个实用且可扩展的工具，以指导针对不同靶蛋白和 E3 连接酶的配体优化。链接网址：https://pubs.acs.org/doi/10.1021/acs.analchem.5c06619 DOI：https://doi.org/10.1021/acs.analchem.5c06619 3.【虚拟筛选】传统的分子筛选方法往往受到高昂的计算成本、漫长的设计周期以及对高质量三维蛋白质结构的强烈依赖的限制，而这些条件并非总是具备或可靠的。为了解决这些问题，我们提出了 CoDrug，这是一种创新的多模态融合框架，它将文本信息与蛋白质和化合物的结构表示相结合。CoDrug 采用了两种互补的融合策略——文本-蛋白质序列融合，其中 SciBERT 对功能描述进行编码，ESM 提取序列级特征；以及文本-化合物结构融合，其中 ChemFormer 对 SMILES 进行编码，SciBERT 处理与化合物相关的文本描述。对各种基准测试的评估表明，CoDrug 的表现与当前最先进的基线相比具有竞争力或更优的效果，尤其是在 3D 结构数据不完整或不可用的情况下。该框架的自然语言接口降低了人工智能辅助药物发现的技术门槛，使化学家能够无需具备专门的计算能力知识就能高效地探索和优化化学空间。通过将语言驱动的假设与结构引导的分子设计相结合，CoDrug 提供了一种可扩展且灵活的范式，用于加速药物发现的早期阶段。链接网址：https://pubs.acs.org/doi/10.1021/acs.jcim.5c02499 DOI：https://doi.org/10.1021/acs.jcim.5c02499 4.【深度学习】动机：DNA 结合蛋白（DBP）在整个生物系统中起着重要作用。随着生物信息学的迅速发展，对高效计算协议的需求日益增加，以预测 DBP。已设计了几种基于序列的计算工具来预测 DBP；然而，仍有研究缺口需要进一步改进。方法：我们开发了一种基于深度学习（DL）的新颖预测器，称为 DeepDBPI，以增强 DBP 预测能力。所提出的 DeepDBPI 模型利用蛋白质序列的进化和图形属性，使用新颖的描述符，即基于协方差相关性的位置特定得分矩阵（CC-PSSM）、基于二进制图谱的（BP-PSSM）、三元组（TRG-PSSM）以及基于图形和统计的特征编码（FEGS）方法。然后，我们应用小波去噪（WD）算法来去除从序列中获得的特征中的噪声。我们将过滤后的特征输入到 ResNet、LSTM、BiLSTM、RNN、BiRNN 和 BiGRU 中。结果：在 5 折交叉验证中，使用基于去噪的 FEGS 编码方法的 DeepDBPI 模型以 Bi-GRU 的形式表现出了最佳的预测性能，通过 ACC、SN、SP 和 MCC 进行评估。我们提出的模型在独立测试中取得了 92.13% 的 ACC、93.07% 的 SN、91.19% 的 SP 和 0.8427 的 MCC。我们认为所开发的生物信息学协议的有效性为药物发现和其他蛋白质组问题提供了见解。所有数据，包括数据集、特征提取技术以及模型，均可在以下网址获取：https://doi.org/10.5281/zenodo.17496063 链接网址：https://pubs.acs.org/doi/10.1021/acs.jcim.5c02637 DOI：https://doi.org/10.1021/acs.jcim.5c02637 5.【分子动力学模拟】抑制二肽基肽酶 4（DPP-4）是治疗 2 型糖尿病（T2DM）的关键策略。然而，目前的抑制剂往往存在不良毒性，这凸显了需要寻找新的、选择性更高且更安全的替代方案。本研究采用了一种综合计算流程，以加快新 DPP-4 抑制剂候选物的识别。为此，将 30，699 个具有生物活性的 PubChem 化合物的 GPU 加速分子对接与分子动力学（MD）模拟以及膜渗透性分析相结合。基于 Uni-Dock 预测的结合评分，提出了一种系统筛选候选物的工作流程。化合物EPZ005687、OSU-03012 和 bemcentinib 在 S1、S2、S1′、S2′和 S2′口袋中的结合亲和力更高，与 FDA 批准的参考药物（如阿格列汀）相比，其内部相互作用也更有利，这是基于 MM-GBSA 计算得出的。结果表明，EPZ005687、OSU-03012 和 bemcentinib 的渗透特性优于阿格列汀。这些高靶标亲和力和增强的细胞渗透性的综合证据强烈表明，这些化合物是即将崭露头角的抗糖尿病药物。这些发现展示了这种综合计算策略的效力，以及对经过严格筛选的公共数据库的利用，对于加快发现更安全、更有效的抗糖尿病治疗方法具有重要意义。链接网址：https://pubs.acs.org/doi/10.1021/acsomega.5c08231 DOI：https://doi.org/10.1021/acsomega.5c08231 6.【逻辑门】核酸和蛋白质被公认为疾病诊断和病原体检测的金标准生物标志物。然而，传统的单一分析检测方法仍容易受到人为操作错误或样本污染导致的假阳性干扰，从而降低了诊断的可靠性，并增加了医疗系统的负担。为解决这一局限性，我们开发了一种一体式恒温扩增与 CRISPR-Cas 合作系统（OIACS），该系统作为一种“AND-logic”逻辑生物传感器，可同时检测 SARS-CoV-2 RNA 和核衣壳蛋白。与仅依赖 CRISPR RNA（crRNA）识别的传统方法不同，OIACS 采用抗体介导的靶标结合并释放阻断剂来实现靶标识别，这为针对不同靶标的设计提供了更大的灵活性。通过等温扩增的链置换技术生成一种通用的 Cas12a 可靶向的 DNA 标记物，从而在双靶标识别时实现信号放大。OIACS 检测法具有实际应用价值，能够可靠地检测出每毫升 5000 个拷贝的具有转录和复制能力的新冠病毒样颗粒，其检测下限被确定为低至 1698 个拷贝/毫升，这凸显了其可靠性和在临床诊断中的潜力。链接网址：https://pubs.acs.org/doi/10.1021/acs.analchem.5c07321 DOI：https://doi.org/10.1021/acs.analchem.5c07321 上下滚动查看更多药企动态2026年1月23日【赛诺菲】赛诺菲全球首创OX40L单抗两项III期研究成功，计划申报上市2026年1月23日【箕星药业】箕星药业完成20亿融资2026年1月22日【复星医药】复星医药拟分拆疫苗子公司赴港上市2026年1月22日【阿斯利康】第 7 项！阿斯利康「度伐利尤单抗」国内获批新适应症2026年1月21日【礼来】礼来替尔泊肽拟纳入突破性疗法，适应症为代谢相关脂肪性肝病2026年1月21日【OpenEvidence】估值120亿美元！AI医疗公司完成2.5亿美元D轮融资各动态具体信息，请滑动下方文字 1.【赛诺菲】 1月23日，赛诺菲宣布Amlitelimab治疗特应性皮炎的两项III期研究（SHORE和COAST 2）达到主要终点。此前，该药物在2025年9月已有一项III期研究达到主要终点。链接网址请戳我 2.【箕星药业】今日（1月23日），箕星药业宣布完成2.87亿美元（约合20亿元人民币）D1轮融资。本轮融资由SR One、TCGX、RA Capital Management、HBM Healthcare Investments等新投资方参与，此次融资将主要用于推进核心产品口服小分子GLP-1受体激动剂CX11的全球临床开发，以及公司运营能力的提升。链接网址请戳我 3.【复星医药】 1月22日，复星医药发布公告，拟分拆其所属子公司复星安特金至香港联交所主板上市。公告指出，复星安特金在香港上市的发行时间及定价尚未确定，建议分拆上市尚需取得复星医药股东批准、完成中证监备案、并获得联交所及其他相关部门批准。建议分拆上市完成后，预计复星安特金仍为复星医药之附属公司，复星安特金的财务状况和盈利能力仍将反映在复星医药合并财务报表数据中。链接网址请戳我 4.【阿斯利康】 1 月 22 日，阿斯利康宣布，英飞凡®（通用名：度伐利尤单抗）已获 NMPA 批准，与卡铂和紫杉醇联合用于错配修复缺陷（dMMR）的原发晚期或复发性子宫内膜癌成人患者的一线治疗，随后以本品单药维持治疗。链接网址请戳我 5.【礼来】 1月21日，CDE官网显示，礼来的GIP/GLP-1双受体激动剂替尔泊肽拟纳入突破性疗法，用于治疗代谢相关脂肪性肝病（MASH）。链接网址请戳我 6.【OpenEvidence】 1月21日，迈阿密，OpenEvidence是美国医生使用最广泛的人工智能平台，宣布完成2.5亿美元D轮融资，对该公司的估值为120亿美元。这使得OpenEvidence成为世界上最有价值的医疗AI公司。链接网址请戳我上下滚动查看更多会议信息 2026年3月19-20日上海恺默信息咨询有限公司举办PMO 2026第三届多肽及代谢&减肥药物峰会 2026年4月9-10日举办AntibodyChina 2026第九届抗体药物与ADC药物深度聚焦峰会 2026年5月21-22日上海求实医药咨询有限公司举办I-RNA 2026 第六届核酸药物产业深度聚焦峰会 2026年7月2-3日智药邦举办2026人工智能与生物医药生态大会各会议具体详情和参会方式，请滑动下方文字 PMO 2026第三届多肽及代谢&减肥药物峰会主办方：上海恺默信息咨询有限公司会议时间：2026年3月19-20日会议地点：上海会议主旨：聚焦关键技术问题、代表性项目与典型企业案例，力求在交流中厘清方向，在争议中捕捉价值，推动产业回归“有效、可实现”的创新逻辑。链接网址请戳我 AntibodyChina 2026第九届抗体药物与ADC药物深度聚焦峰会会议时间：2026年4月9-10日会议地点：上海会议主旨：聚焦从下一代ADC技术革新、双抗机制进化，到TCE开发实践及全球化布局的全链条议题。峰会不仅呈现最新研发与临床进展，也剖析出海策略与产业化实践，助力国内抗体药物产业在全球舞台上实现突破与整合。链接网址请戳我 I-RNA 2026 第六届核酸药物产业深度聚焦峰会主办方：上海求实医药咨询有限公司会议时间：2026年5月21-22日会议地点：苏州会议主旨：聚焦前沿研发与战略布局，深入讨论技术难点、产业机遇与未来趋势，为核酸药物的创新与落地提供全景洞察。链接网址请戳我 2026人工智能与生物医药生态大会主办方：智药邦会议时间：2026年7月2-3日会议地点：上海会议主旨：将以主论坛、分论坛及多个特色生态活动相结合的形式，全景呈现AI在从靶点发现、药物分子设计到临床转化的关键环节中的创新实践，并深入探讨跨国药企AI战略、AI Biotech成长路径、数据与算力基础设施演进，以及监管与资本协同等核心议题。链接网址请戳我上下滚动查看更多版权信息本文内容均由小编收集于公开的各个网络平台，发布的目的仅为了方便大家一站式了解AIDD行业信息，并未对发布源头进行真实性验证。如您发现相关信息有任何版权侵扰或者信息错误，请及时联系AIDD Pro（请添加微信号Cynthia_qin1114）进行删改处理。原创内容未经授权，禁止转载至其他平台。有问题可发邮件至qinxin@stonewise.cn 关注我，更多资讯早知道↓↓↓

临床结果临床1期信使RNA

2026-01-22

·三弟药闻

20260122 中国国家药品监督管理局药品审评中心(CDE)受理信息--化药

1-2 LOU064片受理号：JXHL2600026, JXHL2600025 (两项均为进口化药临床申请) 药品名称：LOU064片企业名称：Novartis Pharma AG; China Novartis Institutes for BioMedical Research Co., Ltd. (诺华公司) 靶点与机制：一种高效、不可逆的BTK共价抑制剂注册与分类：2.4类 (改良型新药-新适应症)3-4 盐酸溴己新口服溶液受理号：CYHS2600256, CYHS2600255 (两项均为国产化药仿制上市申请) 药品名称：盐酸溴己新口服溶液企业名称：石家庄凯达生物工程有限公司; 山东简道制药有限公司靶点与机制：黏液溶解性祛痰药。可分解痰液中酸性糖蛋白的多糖纤维，降低痰液黏稠度，使其易于咳出。适用于慢性支气管炎、哮喘、支气管扩张等有白色黏痰不易咳出的患者。注册与分类：3类 (仿制药)5 碘佛醇注射液受理号：CYHS2600254 (国产化药仿制上市申请) 药品名称：碘佛醇注射液企业名称：福建森福润医药科技有限公司; 扬子江药业集团有限公司靶点与机制：非离子型含碘X射线造影剂。通过静脉注射提高血管和组织的X射线不透性，用于计算机断层扫描（CT）的增强显影，帮助诊断血管、器官和组织的病变。注册与分类：4类 (仿制药)6-7 苯甲酸阿格列汀片受理号：CYHB2600140, CYHB2600139 (两项均为国产化药补充申请) 药品名称：苯甲酸阿格列汀片企业名称：宁波美诺华天康药业有限公司; 宁波美诺华天康药业有限公司靶点与机制：二肽基肽酶-4抑制剂。通过抑制DPP-4酶，减少体内胰高血糖素样肽-1的失活，从而以葡萄糖浓度依赖性方式促进胰岛素分泌、抑制胰高糖素分泌，用于治疗2型糖尿病。注册与分类：4类 (补充申请，针对已上市仿制药)8-9 氯化钾颗粒受理号：CYHB2600138, CYHB2600137 (两项均为国产化药补充申请) 药品名称：氯化钾颗粒企业名称：重庆安诺生生命科技有限公司; 济川药业集团有限公司靶点与机制：电解质补充剂。用于治疗和预防低钾血症，以及洋地黄中毒引起的频发性、多源性早搏或快速性心律失常。注册与分类：3类 (补充申请，针对已上市仿制药)10 泽布替尼胶囊受理号：CXHL2600102 (国产化药新药临床申请) 药品名称：泽布替尼胶囊企业名称：百济神州（苏州）生物科技有限公司靶点与机制：一款高选择性的BTK抑制剂，旨在最大化对BTK靶点的特异性结合注册与分类：2.4类 (改良型新药-新适应症)11 RFUS-1646片受理号：CXHL2600101 (国产化药新药临床申请) 药品名称：RFUS-1646片企业名称：宜昌人福药业有限责任公司靶点与机制：具体靶点与机制未公开注册与分类：1类 (创新药)12-13 NHL35700片受理号：CXHB2600015, CXHB2600014 (两项均为国产化药补充申请) 药品名称：NHL35700片企业名称：上海枢境生物科技有限公司; 江苏恩华药业股份有限公司靶点与机制：靶向多巴胺受体、血清素受体和肾上腺素受体注册与分类：1类 (补充申请，针对在研创新药)14 JKN2306片受理号：CXHB2600013 (国产化药补充申请) 药品名称：JKN2306片企业名称：健康元药业集团股份有限公司; 健康元海滨药业有限公司靶点与机制：适应症为急性疼痛注册与分类：1类 (补充申请，针对在研创新药)15-16 盐酸文拉法辛缓释胶囊受理号：JYHZ2600008, JYHZ2600007 (两项均为进口药品再注册申请) 药品名称：盐酸文拉法辛缓释胶囊企业名称：Upjohn US 2 LLC; Pfizer Ireland Pharmaceuticals Unlimited Company; Viatris Pharmaceuticals Co., Ltd. 靶点与机制：5-羟色胺和去甲肾上腺素再摄取抑制剂。通过抑制中枢神经系统神经元对5-羟色胺和去甲肾上腺素的再摄取，增加这两种神经递质在突触间隙的浓度，从而发挥抗抑郁和抗焦虑作用。缓释剂型可减少血药浓度波动，提高依从性。注册与分类：未标注(进口再注册，药品批件有效期届满后申请延续)17-18 甲磺酸仑伐替尼胶囊受理号：JYHB2600054, JYHB2600053 (两项均为进口化药补充申请) 药品名称：甲磺酸仑伐替尼胶囊企业名称：Eisai Europe Limited; Eisai Co., Ltd. (卫材公司) 靶点与机制：多靶点酪氨酸激酶抑制剂。可抑制血管内皮生长因子受体、成纤维细胞生长因子受体、血小板衍生生长因子受体α、RET和KIT等多个靶点，从而抑制肿瘤血管生成和肿瘤细胞增殖。用于治疗肝细胞癌、甲状腺癌、肾细胞癌等。注册与分类：未标注(进口补充申请，通常涉及生产工艺、质量标准、规格等变更)19 伊曲康唑口服液受理号：JYHB2600052 (进口化药补充申请) 药品名称：伊曲康唑口服液企业名称：Hwang's Pharmaceutical Co., LTD. 靶点与机制：三唑类广谱抗真菌药。通过抑制真菌细胞色素P450依赖的14α-去甲基化酶，干扰麦角固醇的合成，从而破坏真菌细胞膜完整性。口服液剂型适用于口腔、食管等部位的念珠菌感染及系统性真菌感染的序贯治疗。注册与分类：5.2类 (进口化学药品上市申请，指已在境外上市的原研药品申请在中国上市)20-21 沙美特罗替卡松吸入粉雾剂受理号：CYHS2600253 (国产化药仿制上市申请) 药品名称：沙美特罗替卡松吸入粉雾剂企业名称：博瑞制药（苏州）有限公司; 博瑞制药（苏州）有限公司靶点与机制：复方吸入制剂。含沙美特罗（长效β2肾上腺素受体激动剂，长效舒张支气管）和丙酸氟替卡松（吸入性糖皮质激素，强效抗炎）。二者联用可协同控制哮喘和慢性阻塞性肺疾病的症状，是目前主流的控制性药物。注册与分类：4类 (仿制药)22-23 尼莫地平口服溶液受理号：CYHS2600251, CYHS2600250 (两项均为国产化药仿制上市申请) 药品名称：尼莫地平口服溶液企业名称：温岭市创新生物医药科技股份有限公司; 万邦德制药集团有限公司靶点与机制：二氢吡啶类钙通道阻滞剂。选择性作用于脑血管，抑制钙离子进入血管平滑肌细胞，扩张脑血管，改善脑部血流，对缺血性脑损伤有保护作用。用于预防和治疗蛛网膜下腔出血后脑血管痉挛引起的缺血性神经损伤。口服溶液适合吞咽困难患者。注册与分类：3类 (仿制药)24 过氧苯甲酰凝胶受理号：CYHS2600249 (国产化药仿制上市申请) 药品名称：过氧苯甲酰凝胶企业名称：成都市海通药业有限公司; 成都市海通药业有限公司靶点与机制：外用抗菌剂和角质剥脱剂。缓慢释放新生态氧，杀灭痤疮丙酸杆菌；并具有轻度的角质溶解和脱屑作用。用于治疗寻常痤疮。注册与分类：4类 (仿制药)25 富马酸卢帕他定片受理号：CYHS2600248 (国产化药仿制上市申请) 药品名称：富马酸卢帕他定片企业名称：湖北唯森制药有限公司; 湖北唯森制药有限公司靶点与机制：长效、非镇静性抗组胺药。为选择性外周H1组胺受体拮抗剂，同时具有抗血小板活化因子作用。用于缓解成人及12岁以上青少年季节性过敏性鼻炎和慢性特发性荨麻疹的相关症状。注册与分类：4类 (仿制药)26 氟比洛芬钠滴眼液受理号：CYHS2600247 (国产化药仿制上市申请) 药品名称：氟比洛芬钠滴眼液企业名称：江苏福邦药业有限公司; 江苏福邦药业有限公司靶点与机制：非甾体抗炎药。通过抑制环氧化酶，减少前列腺素的合成，从而发挥抗炎、镇痛作用。用于眼科手术前后的抗炎治疗及抑制白内障手术时的瞳孔缩小。注册与分类：4类 (仿制药)27 吸入用布地奈德混悬液受理号：CYHS2600246 (国产化药仿制上市申请) 药品名称：吸入用布地奈德混悬液企业名称：浙江高跖医药科技股份有限公司; 浙江赛默制药有限公司靶点与机制：吸入性糖皮质激素。具有高效局部抗炎作用，能增强内皮细胞、平滑肌细胞和溶酶体膜的稳定性，抑制免疫反应和降低抗体合成，从而减轻气道高反应性和炎症。是哮喘和慢性阻塞性肺疾病控制治疗的基石药物。注册与分类：4类 (仿制药)28 阿达帕林凝胶受理号：CYHS2600245 (国产化药仿制上市申请) 药品名称：阿达帕林凝胶企业名称：江苏迪赛诺制药有限公司; 江苏迪赛诺制药有限公司靶点与机制：第三代维A酸类药物。具有调节毛囊角质形成细胞分化、溶解微粉刺和抗炎作用。用于治疗以粉刺、丘疹和脓疱为主要表现的轻中度寻常痤疮。注册与分类：4类 (仿制药)29 注射用戈舍瑞林微球受理号：CYHB2600136 (国产化药补充申请) 药品名称：注射用戈舍瑞林微球企业名称：山东绿叶制药有限公司; 山东绿叶制药有限公司靶点与机制：促性腺激素释放激素激动剂。持续给药可抑制垂体分泌促黄体生成素和促卵泡素，从而降低卵巢雌激素或睾丸睾酮的生成，达到“药物去势”效果。微球为长效缓释剂型。用于前列腺癌、乳腺癌、子宫内膜异位症等激素依赖性疾病的治疗。注册与分类：2.2类 (补充申请，针对已上市的改良型新药-新剂型)30 钠钾镁钙注射用浓溶液受理号：CYHB2600135 (国产化药补充申请) 药品名称：钠钾镁钙注射用浓溶液企业名称：山东新华制药股份有限公司; 山东华鲁制药有限公司靶点与机制：电解质补充剂。用于补充细胞外液（如手术、外伤、脱水等引起的体液丢失）及作为水溶性药物的稀释溶剂。注册与分类：3类 (补充申请，针对已上市仿制药)31 盐酸小檗碱片受理号：CYHB2600134 (国产化药补充申请) 药品名称：盐酸小檗碱片企业名称：上海葆隆生物科技有限公司; 大连胜光药业集团股份有限公司靶点与机制：异喹啉类生物碱。传统用于肠道感染，如胃肠炎、细菌性痢疾等。现代研究表明其具有降血糖、调血脂、抗心律失常等多种药理活性，但确切机制复杂，涉及AMPK激活、肠道菌群调节等多途径。注册与分类：未标注(补充申请，针对已上市药品)32-33 玻璃酸钠滴眼液受理号：CYHB2600133, CYHB2600132 (两项均为国产化药补充申请) 药品名称：玻璃酸钠滴眼液企业名称：石家庄格瑞药业有限公司; 石家庄格瑞药业有限公司靶点与机制：人工泪液/眼部润滑剂。玻璃酸钠是广泛存在于人体内的天然多糖，具有优异的保水性和粘弹性。作为滴眼液，可稳定泪膜、润滑眼表、缓解干眼症状，并促进角膜上皮损伤的修复。注册与分类：4类 (补充申请，针对已上市仿制药)34 注射用头孢他啶阿维巴坦钠受理号：CYHB2600131 (国产化药补充申请) 药品名称：注射用头孢他啶阿维巴坦钠企业名称：齐鲁制药有限公司; 齐鲁安替制药有限公司; 齐鲁制药有限公司靶点与机制：β-内酰胺类复方抗生素。头孢他啶为第三代头孢菌素，抑制细菌细胞壁合成；阿维巴坦为新型β-内酰胺酶抑制剂，可抑制包括碳青霉烯酶在内的多种Ambler A类、C类和部分D类酶。用于治疗由耐药革兰阴性菌引起的复杂感染。注册与分类：未标注(补充申请，针对已上市药品)35-36 GLR2037片受理号：CXHL2600099, CXHL2600098 (两项均为国产化药新药临床申请) 药品名称：GLR2037片企业名称：甘李药业股份有限公司靶点与机制：具体靶点与机制未公开注册与分类：1类 (创新药)37 SMLT24013片受理号：CXHL2600095 (国产化药新药临床申请) 药品名称：SMLT24013片企业名称：陕西医药控股集团生物制品有限公司靶点与机制：具体靶点与机制未公开注册与分类：2.2类 (改良型新药-新剂型、新给药途径、新复方制剂)38 盐酸左沙丁胺醇异丙托溴铵吸入溶液受理号：CXHL2600094 (国产化药新药临床申请) 药品名称：盐酸左沙丁胺醇异丙托溴铵吸入溶液企业名称：济南景笙科技有限公司靶点与机制：复方支气管扩张剂。含左沙丁胺醇（左旋体，为β2肾上腺素受体激动剂，起效快，松弛支气管平滑肌）和异丙托溴铵（抗胆碱能药物，阻断M受体，降低迷走神经张力，舒张支气管）。二者作用机制互补，协同用于慢性阻塞性肺疾病的治疗。注册与分类：2.1类 (改良型新药-含有已知活性成份的新复方制剂)39-40 KBD104409片受理号：CXHL2600093, CXHL2600092 (两项均为国产化药新药临床申请) 药品名称：KBD104409片企业名称：康百达(四川)生物医药科技有限公司靶点与机制：具体靶点与机制未公开注册与分类：1类 (创新药)41 醋丙甲泼尼龙乳膏受理号：CXHB2600012 (国产化药补充申请) 药品名称：醋丙甲泼尼龙乳膏企业名称：广东华润顺峰药业有限公司; 广东华润顺峰药业有限公司靶点与机制：中效外用糖皮质激素。醋丙甲泼尼龙是甲泼尼龙的酯类衍生物，具有抗炎、抗过敏、抗增生及止痒作用。用于对皮质类固醇治疗有效的非感染性炎症性皮肤病，如湿疹、神经性皮炎、银屑病等。注册与分类：3类 (补充申请，针对已上市仿制药)

申请上市临床申请引进/卖出

2026-01-13

·CVDAILY

全球糖尿病速递（第013期）｜糖尿病门诊电子病历、糖皮质激素的血糖效应、运动依从性干预措施

*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放截至01月13日15点59分，近期共有 433 本期刊发布了 850 篇文章，其中糖尿病相关的文章共 318 篇，覆盖 37 个领域的内容。中国专家参与发表的文章有 55 篇。今日，影响因子最高的文章刊登在 Signal transduction and targeted therapy (IF: 52.700) 期刊上。今日头条 Headlines 01 Int J Med Inform IF: 04.100 临床医生对电子病历在糖尿病门诊护理中应用的视角：一项定性研究 Wang, Wenyong, Samadbeik, Mahnaz, Puri, Gaurav, McLeod, Donald S A, Lobo, Elton, Duong, Tuan, etc. 近日，一项定性研究深入探讨了临床医生在糖尿病门诊护理中使用电子病历（EMR）的真实体验与看法。该研究由Wenyong Wang等共同完成，旨在填补EMR在特定门诊场景下影响证据的空白。研究在澳大利亚昆士兰州一家大都市糖尿病服务中心开展，采用了焦点小组的形式，共有22名来自不同岗位的临床医生参与，包括医生、护士和专职医疗人员。数据分析结合了“Quintuple Aim”（五重目标）框架和“技术接受模型”，以期全面评估EMR对医疗质量、效率及医护人员体验的多维度影响。研究发现，临床医生对EMR的感受呈现显著的“双面性”。积极的一面是，医生们普遍认为，EMR提高了工作效率，使得获取患者历史信息、检验结果和既往处方变得前所未有的便捷。在安全性方面，系统内置的处方审核与警示功能，被认为有效降低了用药错误的风险。然而，临床医生也提及系统存在导航复杂、界面不够直观、偶发技术故障等问题，影响了使用的流畅度。更为突出的是“警报疲劳”，即系统过多的弹窗和提醒，可能导致重要信息被忽略，反而增加了认知负荷。此外，如何在系统中进行恰当、高效的文档记录，以及如何应对患者因知晓EMR存在而产生的不同期望，都让临床人员感到压力。研究还指出，初期庞杂而缺乏针对性的培训，也加重了医护人员的适应负担。综合这些正反两方面的体验，研究得出结论：在当前糖尿病门诊场景下，EMR确实在提升信息可及性、工作流程效率和医疗安全方面发挥了关键作用。但同时，其现有的设计逻辑和部署方式，也给临床医生的工作体验和幸福感带来了不容忽视的负面影响。研究人员特别指出，像糖尿病这类需要长期、综合数据管理的慢性病，其复杂的护理需求（例如血糖趋势的整合分析）可能尚未被通用型EMR系统完美支持。基于这些发现，研究团队强调，EMR的部署与优化应被视为一项持续的质量改进工程，而非一次性技术安装。他们呼吁，未来的努力方向应包括大力改善系统可用性、提供分角色、场景化的精准培训、确保技术基础设施的稳定可靠，并且必须让一线临床医生深度参与到系统的优化设计中。未来的研究应解决可用性挑战，增强整合，并确保临床医生和患者的观点共同引领数字健康转型。本文由韩玉莲编辑扫描二维码查看源文 Int J Med Inform | Ahead of Print. 10.1016/j.ijmedinf.2026.106275 02 Diabetes, obesity & metabolism IF: 05.700 糖皮质激素在1型糖尿病中应用的系统综述：血糖效应与临床管理策略 Katz, Alexandra, Shulkin, Aidan, Housni, Asmaa, Roy-Fleming, Amélie, Rabasa-Lhoret, Rémi, Yale, Jean-Francois, etc. 近日，一项Alexandra Katz等学者发表的系统综述，深入探讨了糖皮质激素（GCs）在1型糖尿病患者中的应用及其对血糖管理带来的挑战。糖皮质激素是治疗炎症和自身免疫性疾病的常用药物，但其一个众所周知的副作用是诱发高血糖。对于依赖胰岛素治疗的1型糖尿病患者而言，如何在GCs治疗期间调整胰岛素剂量以维持血糖稳定，是一个复杂的临床难题，且目前缺乏清晰的管理建议。这项系统性研究检索了截至2025年8月的多个医学数据库，共纳入了22项相关研究，涉及总计368名成年1型糖尿病患者。分析结果表明，无论采用何种剂型、剂量或给药途径，GCs治疗均与明显的血糖波动和胰岛素需求量上升密切相关。无论是GCs口服或静脉给药，胰岛素需求都需要在基线水平上大幅增加，部分研究中增幅高达70%。研究进一步揭示了不同临床情境下的差异。在妊娠期使用产前糖皮质激素时，通过结构化的皮下或静脉胰岛素输注方案进行管理，效果较为理想。而对于关节内注射等局部给药的GCs，其引起的血糖升高可能延迟出现，但持续时间较长，需要更长时间的严密血糖监测。随着糖尿病管理技术的进步，自动胰岛素输注系统（AID）在此场景下的作用也受到了关注。现有证据提示，AID系统可能有助于减轻GCs引发的血糖升高幅度，但系统仍然需要使用者根据情况进行主动干预和调整。基于现有证据，综述指出，GCs治疗确实会显著扰乱1型糖尿病患者的血糖稳定性。其影响程度和模式取决于药物本身特性、给药方式以及患者个体因素和具体的临床背景。目前，最为切实可行的管理策略是采取主动、个体化的方法，即根据所用GCs的药代动力学特点，预先规划和调整胰岛素剂量，并辅以频繁的血糖监测或连续血糖监测技术的使用。研究者最后强调，为了优化1型糖尿病患者的合并用药管理，未来仍需开展更多研究，以建立基于高质量证据的临床指南，并进一步阐明像AID这样的先进技术在应对GCs相关高血糖中的确切角色和最佳使用方案。本文由韩玉莲编辑扫描二维码查看源文 Diabetes, obesity & metabolism | Ahead of Print. 10.1111/dom.70465 03 Journal of obesity IF: 03.900 促进超重或肥胖人群运动依从性的干预措施有效性：一项系统综述 Rodrigues, Matheus de Sena Anchieta, Atanasio, Lívia de Melo, Dos Santos, Isis Kelly, da Silva, José Carlos Gomes, Cabral, Breno Guilherme de Araujo Tinoco, Dantas, Paulo Moreira Silva, etc. 近日，一项发表在Journal of Obesity上的系统综述研究，为我们理解如何帮助超重或肥胖人群坚持运动提供了新的证据。该研究系统评估了旨在提升该人群运动依从性的各种干预措施，揭示了可能有效的策略，同时也指出了当前研究领域的局限。这项研究由Rodrigues等人完成，他们检索了包括MEDLINE、Embase在内的五大数据库，最终纳入了17项符合标准的随机对照试验。这些研究覆盖了美国、加拿大、澳大利亚、欧洲等多个地区，干预时长从12周到2年不等，旨在探索不同方法对运动坚持情况的影响。分析结果显示，在多种干预形式中，**以小组形式开展的运动项目**以及**由受过培训的专业人员直接监督的干预**，显示出与更高运动依从性相关的积极趋势。这意味着，在集体环境中锻炼或获得专业的现场指导，可能更有利于超重或肥胖个体克服障碍，将运动计划坚持下去。而干预措施是否结合了饮食指导或心理行为策略、运动的频率、每次的时长和强度如何，以及参与者的体重，在这些研究中都未发现它们与运动依从性水平存在稳定的关联。大多数研究存在中度至高度的偏倚风险，这意味着其结果可能受到各种混杂因素或设计缺陷的影响，从而限制了当前证据的可靠性。因此，尽管本综述指出了集体与有监督的干预措施可有效提高超重或肥胖成年人的锻炼依从性，但研究者强调乐未来在该领域进行更严谨、设计更精良的随机对照试验的必要性。未来的研究需要更清晰地描述干预细节，采用更客观、一致的依从性测量方法，并关注如何维持长期的运动参与，尤其是在干预数月之后依从性可能下降的关键时期。本文由韩玉莲编辑扫描二维码查看源文 Journal of obesity | Volume 2025, Issue 10.1155/jobe/4164477 中国发表（55） China J Health Popul Nutr IF: 02.800Ahead of Print.No.01Time-restricted eating in overweight and obese adults: an evidence summary and clinical recommendations限时进食在超重和肥胖成人中的应用：一项证据总结与临床建议DOI: 10.1186/s41043-025-01221-6 BMC musculoskeletal disorders IF: 02.400Ahead of Print.No.02Does metabolically healthy obesity increase the risk of knee and hand osteoarthritis? A population-based cohort study代谢健康型肥胖是否会增加膝与手骨关节炎风险？一项基于人群的队列研究DOI: 10.1186/s12891-026-09495-5 BMC pediatrics IF: 02.000Ahead of Print.No.03Association between dietary folate intake and obesity in children and adolescents: a cross-sectional NHANES study饮食中叶酸摄入量与儿童青少年肥胖的关联：一项横断面NHANES研究DOI: 10.1186/s12887-025-06490-y Appl Microbiol Biotechnol IF: 04.300Ahead of Print.No.04Distinct oral and fecal microbiota composition in preschool children with overweight/obesity: a cross-sectional study学龄前超重/肥胖儿童存在独特的口腔和粪便微生物群组成：一项横断面研究DOI: 10.1007/s00253-025-13685-x International journal of obesity IF: 03.800Ahead of Print.No.05Multidimensional risk impact of obesity on breast cancer incidence, treatment, and prognosis肥胖对乳腺癌发病率、治疗和预后的多维风险影响DOI: 10.1038/s41366-025-02008-9 Cellular signalling IF: 03.700Ahead of Print.No.06Role of CTRP9 in obesity-associated microglial dysregulation: Promoting lipophagy via the PI3K/AKT/FOXO1 signaling pathwayCTRP9在肥胖相关小胶质细胞失调中的作用：通过PI3K/AKT/FOXO1信号通路促进脂自噬DOI: 10.1016/j.cellsig.2026.112358 Acta clinica belgica : IF: 01.100Ahead of Print.No.07A comprehensive review and meta-analysis of relationship between age of onset or duration of type 2 diabetes and mortality involving more than 2.85 million patients涵盖超285万患者的大型综述与荟萃分析：全面评估2型糖尿病发病年龄或病程与死亡率的关系DOI: 10.1080/17843286.2026.2615091 Environmental research IF: 07.700Volume 291, Issue No.08Associations of concomitant exposure to outdoor light at night, air pollution, and greenness with metabolic syndrome: A cohort study in China夜间户外光、空气污染与绿地暴露与代谢综合征的关联性研究：一项中国队列研究DOI: 10.1016/j.envres.2025.123590 Biogerontology IF: 04.100Volume 27, Issue 1No.09FOXO: a key target in regulating aging and age-related diseasesFOXO：调控衰老与年龄相关疾病的关键靶点DOI: 10.1007/s10522-025-10380-2 European journal of pharmacology IF: 04.700Ahead of Print.No.10SIRT1-mediated YAP deacetylation suppresses myocardial hypertrophy in diabetic cardiomyopathySIRT1介导的YAP去乙酰化抑制糖尿病心肌病中的心肌肥大DOI: 10.1016/j.ejphar.2026.178538 BMC Cardiovascular Disorders IF: 02.300Ahead of Print.No.11Association of triglyceride-glucose index with all-cause mortality in critically ill non-diabetic ischemic stroke: a retrospective cohort study based on the MIMIC-IV database甘油三酯-葡萄糖指数与危重非糖尿病缺血性卒中患者全因死亡率的关联：一项基于MIMIC-IV数据库的回顾性队列研究DOI: 10.1186/s12872-025-05458-1 BMC infectious diseases IF: 03.000Ahead of Print.No.12Correlation analysis between the prevalence of hyperuricemia and the triglyceride-glucose index in adult patients with brucellosis成人布鲁氏菌病患者高尿酸血症患病率与甘油三酯-葡萄糖指数的相关性分析DOI: 10.1186/s12879-026-12532-2 Eur J Med Res IF: 03.400Ahead of Print.No.13Modified cardiometabolic index outperforms conventional indices in discriminating relative muscle loss: a cross-sectional analysis of NHANES 2011-2018改良心脏代谢指数在鉴别相对肌肉减少方面优于传统指数：一项基于NHANES 2011-2018的横断面分析DOI: 10.1186/s40001-026-03879-y Community dental health IF: 01.000Ahead of Print.No.14Effect of type 1 diabetes on oral lichen planus mediated by IL-101型糖尿病通过IL-10介导对口腔扁平苔藓的影响DOI: 10.1177/0265539X261416458 Yingyong shengtai xuebaoVolume 37, Issue 1No.15[Effects of γ-aminobutyric acid and chlorinated hemin composite coating on seed germination and seedling growth of Psathyrostachys juncea under drought and salt stresses]γ-氨基丁酸与氯化血红素复合包衣对新麦草种子萌发及幼苗生长在干旱与盐胁迫下的影响DOI: 10.13287/j.1001-9332.202601.011 NeuroImage IF: 04.500Volume 325, Issue No.16Aberrant thalamic GABA-network coupling as a neural signature of insomnia severity in major depressive disorder丘脑GABA-网络耦合异常作为重度抑郁症失眠严重程度的神经特征DOI: 10.1016/j.neuroimage.2025.121639 Current eye research IF: 02.000Ahead of Print.No.17Association Between Pancreatic β-Cell Function and Quantitative OCT Angiography Metrics in Patients with Type 2 Diabetes Without Clinical Diabetic Retinopathy2型糖尿病无临床视网膜病变患者胰腺β细胞功能与定量OCTA指标之间的关联DOI: 10.1080/02713683.2026.2612760 Cell & bioscience IF: 06.200Ahead of Print.No.18Combination of GLP-1 receptor agonist and Akkermansia muciniphila Akk11 reduces adiposity and ameliorates MASLD in T2D miceGLP-1受体激动剂与嗜黏蛋白阿克曼氏菌Akk11联用减轻2型糖尿病小鼠肥胖并改善MASLDDOI: 10.1186/s13578-025-01525-4 Food & function IF: 05.400Volume 17, Issue 1No.19Pro-inflammatory and pro-oxidant diets and CKD risk across cardiovascular-kidney-metabolic syndrome stages: a multi-omics mediation analysis促炎与促氧化饮食在心血管-肾脏-代谢综合征各阶段与慢性肾病风险：一项多组学中介分析DOI: 10.1039/d5fo03952e Food & function IF: 05.400Volume 17, Issue 1No.20Bifidobacterium animalis subsp. lactis Bbm-19 ameliorates insomnia by remodeling the gut microbiota and restoring γ-aminobutyric acid and serotonin signaling动物双歧杆菌乳亚种Bbm-19通过重塑肠道菌群及恢复γ-氨基丁酸与血清素信号改善失眠DOI: 10.1039/d5fo04374c Circulation IF: 38.600Volume 153, Issue 2No.21Letter by Zhao Regarding Article, "Oral Semaglutide and Cardiovascular Outcomes in People With Type 2 Diabetes, According to SGLT2i Use: Prespecified Analyses of the SOUL Randomized Trial"Zhao的来函：关于文章“口服司美格鲁肽与2型糖尿病患者心血管结局：基于SGLT2i使用的SOUL随机试验预设分析”DOI: 10.1161/CIRCULATIONAHA.125.076451 J Asian Nat Prod Res IF: 01.300Ahead of Print.No.22Research on the effects and mechanisms of the Yiqi Huoxue Recipe in improving renal injury in diabetic nephropathy through the HIF-1 pathway基于HIF-1通路探讨益气活血方改善糖尿病肾病肾损伤的作用及机制研究DOI: 10.1080/10286020.2025.2602695 The FASEB journal : IF: 04.200Volume 40, Issue 2No.23C-X-C Motif Chemokine Ligand 3 as a Potential Biomarker for Diagnosis and Prognosis of Diabetic Kidney DiseaseC-X-C基序趋化因子配体3作为糖尿病肾脏病诊断和预后的潜在生物标志物DOI: 10.1096/fj.202502236R GeroScience IF: 05.400Ahead of Print.No.24Life-course body shape trajectories and cerebral oxygen metabolism in community-dwelling older adults社区老年人生命周期体型轨迹与脑氧代谢DOI: 10.1007/s11357-025-02082-x Clin Transl Oncol IF: 02.500Ahead of Print.No.25Single-cell and spatial transcriptomics reveal mTOR-driven cellular fate of spindle cells and immune evasion in classic Kaposi's sarcoma单细胞与空间转录组学揭示经典型卡波西肉瘤中mTOR驱动的纺锤体细胞命运与免疫逃逸DOI: 10.1007/s12094-025-04063-0 Apoptosis IF: 08.100Volume 31, Issue 1No.26Propofol attenuates angiogenesis by activating endoplasmic reticulum stress to suppress TFAP2C-driven VEGFA transcription丙泊酚通过激活内质网应激抑制TFAP2C驱动的VEGFA转录来减弱血管生成DOI: 10.1007/s10495-025-02214-w Cardiovascular Drugs and Therapy IF: 03.100Ahead of Print.No.27Empagliflozin Supplementation in Cardioplegic Solution Improves Donor Heart Preservation by Maintaining Mitochondrial Homeostasis在心脏停搏液中补充恩格列净通过维持线粒体稳态改善供体心脏保存DOI: 10.1007/s10557-026-07834-1 Archives of osteoporosis IF: 02.800Volume 21, Issue 1No.28The contested association between MASLD and osteoporosis: a narrative review of heterogeneous evidence and modifying factorsMASLD与骨质疏松的关联备受争议：一项关于异质性证据与修饰因子的叙述性综述DOI: 10.1007/s11657-025-01639-9 Advanced materials IF: 26.800Ahead of Print.No.29An AI-embedded, Wearable Dual Closed-Loop Insulin Delivery System for Precision Diabetes Management一种用于精准糖尿病管理的AI嵌入式可穿戴双闭环胰岛素输送系统DOI: 10.1002/adma.202514945 Advanced science IF: 14.100Ahead of Print.No.30HMGB2-RAD21 Axis Promotes Fibro/Adipogenic Progenitor Proliferation and Regulates Fat InfiltrationHMGB2-RAD21轴通过促进纤维/脂肪组细胞增殖调控脂肪浸润DOI: 10.1002/advs.202514363 World J Exp MedVolume 15, Issue 3No.31Systematic review and risk factor analysis of post-vitrectomy silicone oil migration to the central nervous system玻璃体切除术后硅油向中枢神经系统迁移的系统性综述和危险因素分析DOI: 10.5493/wjem.v15.i3.106429 Food Science and Biotechnology IF: 03.100Volume 35, Issue 1No.32Synergistic modulation of metabolic disorders by konjac glucomannan and Polygonatum cyrtonema Hua polysaccharides: integrated insights from in vitro digestion, gut microbiota, and hepatic metabolomics魔芋葡甘聚糖与黄精多糖协同调控代谢紊乱：来自体外消化、肠道菌群和肝脏代谢组学的综合见解DOI: 10.1007/s10068-025-02015-6 Food Science and Biotechnology IF: 03.100Volume 35, Issue 1No.33Active ingredients, nutrition values and health-promoting effects of aboveground parts of rhubarb: a review大黄地上部分的活性成分、营养价值与健康促进功效综述DOI: 10.1007/s10068-025-01919-7 Food science & nutrition IF: 03.800Volume 14, Issue 1No.34Nobiletin Ameliorates Skeletal Muscle Performance in D-Galactose-Induced Aging Mice by Boosting Aerobic Metabolism川陈皮素通过促进有氧代谢改善D-半乳糖诱导衰老小鼠的骨骼肌性能DOI: 10.1002/fsn3.71416 Clinical case reports IF: 00.600Volume 14, Issue 1No.35Central Diabetes Insipidus in Suprasellar Germ Cell Tumor Paradoxically Presenting With Oliguria鞍上生殖细胞瘤所致中枢性尿崩症矛盾性表现为少尿DOI: 10.1002/ccr3.71832 Quant Imaging Med Surg IF: 02.300Volume 16, Issue 1No.36A novel computed tomography-based algorithm for the quantitative identification of lumbar spine-localized trabecular bone loss in patients with type 2 diabetes mellitus基于新型计算机断层扫描算法定量识别2型糖尿病患者腰椎局部骨小梁骨丢失DOI: 10.21037/qims-2025-1312 Journal of clinical nursing IF: 03.500Ahead of Print.No.37Comment on 'Dyadic Patterns of Patient and Caregiver Engagement in Type 2 Diabetes Mellitus Care': Innovative Directions Beyond Static Profiles评《Dyadic Patterns of Patient and Caregiver Engagement in Type 2 Diabetes Mellitus Care》：超越静态特征的创新方向DOI: 10.1111/jocn.70208 Analytical methods IF: 02.600Ahead of Print.No.38A highly sensitive LC-MS/MS method for quantification of AB-38b in rat plasma, liver and kidney tissues: application to a pharmacokinetic study用于定量大鼠血浆、肝及肾组织中AB-38b的高灵敏度LC-MS/MS方法：在药代动力学研究中的应用DOI: 10.1039/d5ay01136a World J Exp MedVolume 15, Issue 3No.39PI3K/AKT/GSK3β regulatory axis in bone mesenchymal stem cells initiates diabetic myocardial infarction via miR-142-3p骨髓间充质干细胞通过miR-142-3p调控的PI3K/AKT/GSK3β通路影响糖尿病心肌梗死DOI: 10.5493/wjem.v15.i3.103948 Digital health IF: 03.300Volume 12, Issue No.40Development of an explainable machine learning model for predicting poststroke anxiety: A multicenter study using Shapley Additive Explanations and nomogram visualization基于SHAP和列线图可视化的可解释机器学习模型预测卒中后焦虑：一项多中心研究DOI: 10.1177/20552076251412575 Int J Ophthalmol IF: 01.800Volume 19, Issue 1No.41Contiguous orbital inflammation from paranasal sinus abnormalities in etiology of thyroid-associated ophthalmopathy鼻旁窦异常引起的毗邻性眼眶炎症在甲状腺相关眼病病因学中的作用DOI: 10.18240/ijo.2026.01.13 Chin J Cancer Res IF: 06.300Volume 37, Issue 6No.42Leukemia epidemiology in China: Burden, trends, and determinants in the 21st century中国白血病流行病学：21世纪的疾病负担、趋势与决定因素DOI: 10.21147/j.issn.1000-9604.2025.06.03 J Diabetes Metab Disord IF: 01.600Volume 25, Issue 1No.43Body mass index mediates the association between serum fibroblast growth factor-19 and diabetes体重指数介导血清成纤维细胞生长因子-19与糖尿病之间的关联DOI: 10.1007/s40200-025-01850-y Annals of medicine IF: 04.300Volume 58, Issue 1No.44Letter to the Editor regarding: 'Global epidemiology of diabetes and prediabetes in lean or non-obese patients with NAFLD: a systematic review and meta-analysis'关于瘦型或非肥胖NAFLD患者中糖尿病与前驱糖尿病全球流行病学特征的系统综述和荟萃分析DOI: 10.1080/07853890.2026.2614829 Artif Cells Nanomed Biotechnol IF: 04.500Volume 54, Issue 1No.45Detection of pathogenic novel intronic splicing variants in the KIDINS220 gene causes motor developmental delay在KIDINS220基因中检测到致病性的新型内含子剪接变异导致运动发育迟缓DOI: 10.1080/21691401.2026.2612914 The FASEB journal : IF: 04.200Volume 40, Issue 2No.46Gpx4 Deletion-Mediated Macrophage Ferroptosis Alleviates Obesity-Associated Insulin Resistance巨噬细胞Gpx4缺失介导的铁死亡缓解肥胖相关的胰岛素抵抗DOI: 10.1096/fj.202503596R Int J Ophthalmol IF: 01.800Volume 19, Issue 1No.47Ranibizumab on optic disc perfusion in central retinal vein occlusion雷珠单抗对视网膜中央静脉阻塞患者视盘血流灌注的影响DOI: 10.18240/ijo.2026.01.10 Food science & nutrition IF: 03.800Volume 14, Issue 1No.48Astragalus membranaceus-Salvia miltiorrhiza Decoction Ameliorates Metabolic Syndrome and Gut Microbiota Dysbiosis Induced by High-Fat Diet: A Comparative Study黄芪-丹参煎剂改善高脂饮食诱导的代谢综合征与肠道菌群失调：一项比较研究DOI: 10.1002/fsn3.71436 RC IF: 01.300Volume 26, Issue 12No.49The Relationship Between the C-reactive Protein-Triglyceride Glucose Index and the Risk of Coronary Heart Disease Alongside the Severity of Coronary Artery Stenosis in Older Adults With Different Levels of Glucose Metabolism: A Real-World Retrospective Clinical StudyC反应蛋白-甘油三酯葡萄糖指数与不同糖代谢水平老年人群冠心病风险及冠状动脉狭窄严重程度的关系：一项真实世界回顾性临床研究DOI: 10.31083/RCM45886 Journal of diabetes research IF: 03.400Volume 2026, Issue No.50Effect of Nordic Walking on Anthropometrics, Glycemia, and Lipid Profile in Adults With Prediabetes or Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials北欧式健走对糖尿病前期或糖尿病患者人体测量学指标、血糖及血脂的影响：随机对照试验的系统综述与Meta分析DOI: 10.1155/jdr/5886930 Transl Androl Urol IF: 01.700Volume 14, Issue 12No.51Associations of different insulin resistance indices with the erectile dysfunction incidence: a cross-sectional analysis of the NHANES 2001-2004不同胰岛素抵抗指数与勃起功能障碍发病率的关联：基于NHANES 2001-2004的横断面分析DOI: 10.21037/tau-2025-665 Transl Androl Urol IF: 01.700Volume 14, Issue 12No.52Exploring the association between the ZJU index and overactive bladder: a cross-sectional study based on NHANES 2011-2018探索ZJU指数与膀胱过度活动症之间的关联：一项基于NHANES 2011-2018的横断面研究DOI: 10.21037/tau-2025-557 Autophagy reportsVolume 5, Issue 1No.53Glycophagy: molecular mechanisms, regulatory signals, and disease associations糖噬：分子机制、调控信号与疾病关联DOI: 10.1080/27694127.2025.2595375 Food science & nutrition IF: 03.800Volume 14, Issue 1No.54Probiotic Supplementation With Bifidobacterium longum Subsp. Longum BL21 Improves Glycemic Control and Modulates Gut Microbiota in Type 2 Diabetes: A Randomized Controlled Trial补充益生菌Bifidobacterium longum subsp. longum BL21改善2型糖尿病患者血糖控制并调节肠道菌群：一项随机对照试验DOI: 10.1002/fsn3.71437 J Gastrointest Oncol IF: 02.000Volume 16, Issue 6No.55Survival outcomes of patients after liver transplantation for patients with hepatocellular carcinoma exceeding the Hangzhou criteria超出Hangzhou标准的肝细胞癌患者肝移植后的生存结局DOI: 10.21037/jgo-2025-aw-864 其他发布内容（260） More Published Articles Int J Biol Macromol IF: 08.500Ahead of Print.No.01Exploring molecular interactions of drugs in different biologically active solvents: A comprehensive review for safe and efficient drug delivery systems探索药物在不同生物活性溶剂中的分子相互作用：安全高效药物递送系统的综合评述DOI: 10.1016/j.ijbiomac.2026.150197 BMC nutrition IF: 02.200Ahead of Print.No.02Vitamin D status and cardiometabolic risk factors among hypertensive and normotensive adults: a hospital-based cross-sectional study in Nepal高血压与血压正常成人的维生素D状况及心脏代谢危险因素：尼泊尔的一项医院横断面研究DOI: 10.1186/s40795-026-01247-x BMC surgery IF: 01.800Ahead of Print.No.03Psoriasis outcomes following metabolic bariatric surgery - a systematic review of the literature代谢减重手术后银屑病转归——文献系统综述DOI: 10.1186/s12893-026-03502-1 Obesity surgery IF: 03.100Ahead of Print.No.04Mortality and Causes of Death After Metabolic Bariatric Surgery in Older Patients老年患者减重手术后的死亡率及死因分析DOI: 10.1007/s11695-026-08487-7 Pharmacological research IF: 10.500Ahead of Print.No.05The Addicted Brain: How Processed Foods Hijack Reward Pathways成瘾的大脑：加工食品如何劫持奖赏通路DOI: 10.1016/j.phrs.2026.108097 BMC medicine IF: 08.300Ahead of Print.No.06SGLT-2 Inhibitor use and liver-related and mortality outcomes in patients with type 2 diabetes and compensated cirrhosis2型糖尿病合并代偿期肝硬化患者使用SGLT-2抑制剂的肝脏相关及死亡率结局DOI: 10.1186/s12916-026-04629-x BMC health services research IF: 03.000Ahead of Print.No.07Facilitating a complex behaviour-change intervention: healthcare professionals' accounts of their journeys to competence and confidence促进一项复杂的行为改变干预：医疗专业人员对其胜任力与信心建立之路的叙述DOI: 10.1186/s12913-025-13676-8 Aging Clin Exp Res IF: 03.400Ahead of Print.No.08Prevalence and predictive factors of cognitive impairment among hospitalized older adults in iran: a cross-sectional study, 2024伊朗住院老年患者认知障碍的患病率及预测因素：一项2024年横断面研究DOI: 10.1007/s40520-025-03299-8 Nature metabolism IF: 20.800Ahead of Print.No.09AMPK at the interface of nutrient sensing, metabolic flux and energy homeostasisAMPK：营养感知、代谢通量与能量稳态的枢纽DOI: 10.1038/s42255-025-01442-3 Nature metabolism IF: 20.800Ahead of Print.No.10Single-cell-resolved transcriptional dynamics of human subcutaneous adipose tissue during lifestyle- and bariatric surgery-induced weight loss人类皮下脂肪组织在生活方式及减重手术诱导体重减轻过程中的单细胞分辨率转录动力学研究DOI: 10.1038/s42255-025-01433-4 Nature communications IF: 15.700Ahead of Print.No.11Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2跨物种证据揭示成人嗜睡症的发育起源与突触黏附分子beat-Ia/CADM2缺失相关DOI: 10.1038/s41467-026-68343-1 Signal Transduct Target Ther IF: 52.700Volume 11, Issue 1No.12MAPK14 converges on key transcriptional machinery to promote vascular smooth muscle cell degeneration in abdominal aortic aneurysmMAPK14通过汇聚关键转录机制促进腹主动脉瘤中血管平滑肌细胞退化DOI: 10.1038/s41392-025-02540-0 Biol Pharm Bull IF: 01.700Volume 49, Issue 1No.13Long-Term Use of Proton Pump Inhibitors Affects Blood Levels of Indoxyl Sulfate in Japanese Patients with Chronic Kidney Disease长期使用质子泵抑制剂影响日本慢性肾脏病患者血液中硫酸吲哚酚水平DOI: 10.1248/bpb.b25-00465 Biol Pharm Bull IF: 01.700Volume 49, Issue 1No.14SMTP-44D Improves High Glucose-Induced Vascular Endothelial DysfunctionSMTP-44D改善高糖诱导的血管内皮功能障碍DOI: 10.1248/bpb.b25-00619 Genes & development IF: 07.700Ahead of Print.No.15Independent control of neurogenesis and dorsoventral patterning by NKX2-2NKX2-2独立控制神经发生与背腹侧模式形成DOI: 10.1101/gad.352886.125 BMJ open IF: 02.300Volume 16, Issue 1No.16Defining chronic ambulatory care sensitive conditions in Malaysia: a collaborative consensus study定义马来西亚慢性门诊诊疗敏感性疾病：一项共识性研究DOI: 10.1136/bmjopen-2025-099891 Physiological reviews IF: 28.700Ahead of Print.No.17Potassium channels in vascular smooth muscle cells血管平滑肌细胞中的钾离子通道DOI: 10.1152/physrev.00017.2025 Preventive medicine IF: 03.200Ahead of Print.No.18An equity audit on intervention effects of a cardiometabolic risk reduction program for women with a history of gestational diabetes in Victoria, Australia澳大利亚维多利亚州妊娠糖尿病史女性心脏代谢风险降低项目干预效果的公平性审计DOI: 10.1016/j.ypmed.2026.108509 Am J Clin Nutr IF: 06.900Ahead of Print.No.19Prediabetes, Diabetes and Folate Status among U.S. Women of Reproductive Age: National Health and Nutrition Examination Survey (NHANES) 2011-March 2020美国育龄女性的前期糖尿病、糖尿病与叶酸状态：全国健康与营养调查(NHANES) 2011年-2020年3月数据DOI: 10.1016/j.ajcnut.2026.101193 Clinical medicine : IF: 03.900Ahead of Print.No.20DIABETES: A MULTISYSTEM DISEASE NEEDING MULTI-DISCIPLINARY CARE糖尿病：一种需要多学科护理的多系统疾病DOI: 10.1016/j.clinme.2026.100554 EJCN IF: 03.900Ahead of Print.No.21Navigating comorbidity: addressing the dual burden of coronary artery disease and diabetes应对共病：管理冠状动脉疾病与糖尿病的双重负担DOI: 10.1093/eurjcn/zvaf238 Am J Physiol Gastrointest Liver Physiol IF: 03.300Ahead of Print.No.22Role of serine/threonine phosphatases 1 and 2A in pancreatic acinar fluid and electrolyte secretion丝氨酸/苏氨酸磷酸酶1和2A在胰腺腺泡液体和电解质分泌中的作用DOI: 10.1152/ajpgi.00304.2025 American journal of perinatology IF: 01.200Ahead of Print.No.23Pregnancy Outcomes in Patients with Type 1 Diabetes Using Continuous Glucose Monitoring使用连续血糖监测的1型糖尿病患者妊娠结局研究DOI: 10.1055/a-2781-7373 Nature reviews. Nephrology IF: 39.800Ahead of Print.No.24Next-generation therapeutics for diabetic kidney disease糖尿病肾病的下一代疗法DOI: 10.1038/s41581-025-01042-0 GeroScience IF: 05.400Ahead of Print.No.25Association between cardiovascular-kidney-metabolic syndrome and risks of 14 age-related health outcomes in primary prevention older population心血管-肾脏-代谢综合征与一级预防老年人群14种年龄相关健康结局风险的关联DOI: 10.1007/s11357-025-02058-x Endocrine journal IF: 02.100Ahead of Print.No.26Pituitary dysfunction in trans-sellar encephalocele: a two-case report and a literature review经蝶鞍脑膨出中的垂体功能障碍：两例报告及文献综述DOI: 10.1507/endocrj.EJ25-0480 BMJ open IF: 02.300Volume 16, Issue 1No.27Challenges in shared decision-making about major lower limb amputation: the PERCEIVE qualitative study关于大截肢共同决策面临的挑战：PERCEIVE定性研究DOI: 10.1136/bmjopen-2025-104407 Nature microbiology IF: 19.400Ahead of Print.No.28Early-life colonization by aromatic-lactate-producing bifidobacteria lowers the risk of allergic sensitization早期生命芳香乳酸产生双歧杆菌定植降低过敏致敏风险DOI: 10.1038/s41564-025-02244-9 BMJ case reports IF: 00.500Volume 19, Issue 1No.29Hypertensive crisis due to secondary aldosteronism from polyarteritis nodosa因结节性多动脉炎继发性醛固酮增多症所致的高血压危象DOI: 10.1136/bcr-2025-269055 BMC pediatrics IF: 02.000Ahead of Print.No.30Association between vitamin D status and insulin resistance in Korean adolescents: differential effects of obesity using non-insulin-based indices韩国青少年维生素D状态与胰岛素抵抗的关联：使用非胰岛素指数评估肥胖的差异效应DOI: 10.1186/s12887-026-06510-5 International journal of obesity IF: 03.800Ahead of Print.No.31Metabolic remodeling and the modulatory role of vitamin D deficiency in African American children and adolescents with obesity非裔美国儿童与青少年肥胖中的代谢重塑及维生素D缺乏的调节作用DOI: 10.1038/s41366-025-02003-0 J Vet Med Sci IF: 01.100Ahead of Print.No.32Hematological, biochemical and hormonal profiles in dogs with obesity-related metabolic disorder犬肥胖相关代谢紊乱的血常规、生化及激素特征分析DOI: 10.1292/jvms.25-0381 Molecular medicine IF: 06.400Ahead of Print.No.33Hepatic loss of AATF attenuates MASH by suppressing AKT-mTORC1 signaling and reprogramming lipid metabolism肝脏缺失AATF通过抑制AKT-mTORC1信号通路与重编程脂质代谢缓解MASHDOI: 10.1186/s10020-025-01417-w Photodiagnosis Photodyn Ther IF: 02.600Ahead of Print.No.34Association of Insulin Therapy with Diabetic Retinopathy in Type 2 Diabetes: A Cross-Sectional Analysis from the Beichen Eye Study胰岛素治疗与2型糖尿病视网膜病变的关联：基于北辰眼研究的横断面分析DOI: 10.1016/j.pdpdt.2026.105345 BMC anesthesiology IF: 02.600Ahead of Print.No.35Anaesthetic management of a pregnant woman with Brugada syndrome undergoing Caesarean section: a case report一例患有布鲁加达综合征的孕妇行剖宫产术的麻醉管理：病例报告DOI: 10.1186/s12871-025-03600-2 BMC psychology IF: 03.000Ahead of Print.No.36Psychological flexibility patterns in patients with type 2 diabetes mellitus and its associations with self-care behavior and medical condition2型糖尿病患者的心理灵活性模式及其与自我护理行为和医疗状况的关联DOI: 10.1186/s40359-025-03930-3 BMC pregnancy and childbirth IF: 02.700Ahead of Print.No.37Is gastroesophageal reflux linked to inflammation-related gestational complications and poor obstetric history?胃食管反流病是否与炎症相关性妊娠并发症及不良产科史有关？DOI: 10.1186/s12884-026-08640-1 Digestive diseases and sciences IF: 02.500Ahead of Print.No.38Impact of Type 2 Diabetes Mellitus on Liver Fibrosis and Hepatic Steatosis in Patients with Primary Biliary Cholangitis: A Longitudinal Study2型糖尿病对原发性胆汁性胆管炎患者肝纤维化和肝脂肪变性的影响：一项纵向研究DOI: 10.1007/s10620-026-09672-5 Clin Microbiol Infect IF: 08.500Ahead of Print.No.39Prevalence and clinical outcomes of RSV, COVID-19, and influenza among older hospitalized adults: The EVERY prospective cohort study老年住院成人中RSV、COVID-19及流感的患病率与临床结局：EVERY前瞻性队列研究DOI: 10.1016/j.cmi.2026.01.002 The Journal of arthroplasty IF: 03.800Ahead of Print.No.40Patients Who Have Metabolic Syndrome Have a Higher Chance of Postoperative Complications After Total Hip Arthroplasty代谢综合征患者在全髋关节置换术后发生并发症的风险更高DOI: 10.1016/j.arth.2026.01.038 CVIR IF: 02.900Ahead of Print.No.41Clinical Outcomes of Balloon-Only Venous Arterialization for Chronic Limb-Threatening Ischemia After Failed or Unfeasible Revascularization单纯球囊静脉动脉化治疗血运重建失败或不可行的慢性肢体威胁性缺血的临床结局DOI: 10.1007/s00270-025-04323-0 PloS one IF: 02.600Volume 21, Issue 1No.42Prevalence, demographic factors, co-morbidities, and treatment types associated with acanthosis nigricans in a large cross-section of 900+ transmasculine patients: Data from a single academic center 2016-2023900余名跨男性患者中黑棘皮病的患病率、人口学因素、合并症及治疗类型关联分析：基于单一学术中心2016-2023年数据DOI: 10.1371/journal.pone.0340907 PloS one IF: 02.600Volume 21, Issue 1No.43ACMTF-R: Supervised multi-omics data integration uncovering shared and distinct outcome-associated variationACMTF-R：基于监督的多组学数据整合，揭示与结果相关的共同及特异性变异DOI: 10.1371/journal.pone.0339650 A&A practice IF: 00.600Volume 19, Issue 12No.44Enhanced Ventilation Strategies in Bariatric Surgery: A Case Report of Flow-Controlled Ventilation in an Extremely Obese Patient Undergoing Robot-Assisted Bariatric Surgery减重手术中增强的通气策略：机器人辅助减重手术中一例极度肥胖患者的流量控制通气病例报告DOI: 10.1213/XAA.0000000000002111 Journal of animal science IF: 02.900Ahead of Print.No.45Overnutrition induced metabolic dysregulation and partially decreased semen quality in young beef bulls营养过剩诱导年轻肉牛代谢失调并部分降低精子质量DOI: 10.1093/jas/skag004 Food & function IF: 05.400Volume 17, Issue 1No.46Hypoglycemic effects under in vitro digestion of brewer's spent yeast β-glucan concentrate added to a rice extrudate酿酒酵母β-葡聚糖浓缩物添加于大米挤压膨化产品后的体外消化降血糖效应DOI: 10.1039/d5fo03588k Diabetes care IF: 16.600Ahead of Print.No.47Impact of Maternal Diabetes in Pregnancy on Newborn IgG Antibody Repertoire and Infection Risk in the First Six Months of Life母体孕期糖尿病对新生儿IgG抗体谱及生命前六个月感染风险的影响DOI: 10.2337/dc25-0990 Hormone research in p?diatrics : IF: 02.700Volume 99, Issue 1No.48Insulin-Induced Copeptin Response in Children and Adolescents to Diagnose Arginine Vasopressin Deficiency胰岛素诱导的和肽素反应在诊断儿童和青少年精氨酸加压素缺乏症中的应用DOI: 10.1159/000541330 Yàowù shípǐn fēnxī IF: 03.000Volume 33, Issue 4No.49Selective sodium-glucose cotransporter two inhibitor empagliflozin ameliorates diabetic cardiomyopathy by activating the AMPK/TFEB signaling pathway选择性钠-葡萄糖协同转运蛋白2抑制剂恩格列净通过激活AMPK/TFEB信号通路改善糖尿病心肌病DOI: 10.38212/2224-6614.3563 Yàowù shípǐn fēnxī IF: 03.000Volume 33, Issue 4No.50Economic evaluation of AI-assisted technologies in healthcare: A systematic review医疗健康领域AI辅助技术的经济学评价：一项系统综述DOI: 10.38212/2224-6614.3570 Brazilian Journal of Nephrology IF: 01.300Volume 48, Issue 2No.51The role of probiotics in modulating the gut microbiota as a potential inhibitor of diabetic kidney disease progression益生菌通过调节肠道菌群作为潜在抑制剂延缓糖尿病肾病进展的机制DOI: 10.1590/2175-8239-JBN-2025-0143en Annals of Internal Medicine IF: 15.200Ahead of Print.No.52Correction: Comparison of an Energy-Reduced Mediterranean Diet and Physical Activity Versus an Ad Libitum Mediterranean Diet in the Prevention of Type 2 Diabetes能量减少地中海饮食与体力活动对比自由摄取地中海饮食预防2型糖尿病的比较DOI: 10.7326/ANNALS-25-04192 Annals of Internal Medicine IF: 15.200Ahead of Print.No.53Predicting Long-Term Risk for Prostate Cancer Mortality Following a Prostate-Specific Antigen Screening Test: Prognostic Model Development and External Validation预测前列腺特异性抗原筛查后前列腺癌死亡的长期风险：预后模型的开发与外部队列验证DOI: 10.7326/ANNALS-25-02036 Natural product research IF: 01.600Ahead of Print.No.54Antitumor and in vivo antioxidant activity of 24-nor-olean-3-one-28-oic acid isolated from the roots of momordica cymbalaria (hook. F.) fenzl ex naudin in Ehrlich ascites carcinoma transplanted mice从Momordica cymbalaria根部分离的24-nor-olean-3-one-28-oic酸在艾氏腹水癌移植小鼠体内的抗肿瘤及体内抗氧化活性DOI: 10.1080/14786419.2026.2615749 ACS chemical neuroscience IF: 03.900Ahead of Print.No.55Synergistic Effect of Mutations in the Amyloidogenic Core of Human Amylin (hAM) Affords a New Potent Inhibitor of hAM Fibrillation: Computational Design and Experimental Validation人类胰淀素（hAM）淀粉样核心突变协同效应产生新型强效hAM纤维化抑制剂：计算设计与实验验证DOI: 10.1021/acschemneuro.5c00433 Neuroepidemiology IF: 04.000Ahead of Print.No.56Incidence, Prevalence, and Treatment Patterns in Chronic Inflammatory Demyelinating Polyneuropathy: Data Analysis of United States Claims慢性炎性脱髓鞘性多发性神经病的发病率、患病率及治疗模式：美国索赔数据分析DOI: 10.1159/000550418 Kidney & Blood Pressure Research IF: 02.100Ahead of Print.No.57Clinical Profile and Outcome of C3-dominant Glomerulonephritis: Retrospective studyC3优势性肾小球肾炎的临床特征与预后：一项回顾性研究DOI: 10.1159/000550422 Hormone research in p?diatrics : IF: 02.700Ahead of Print.No.58Nutrition and healthy lifestyles for children and adolescents with early-stage type 1 diabetes针对早期1型糖尿病儿童和青少年的营养与健康生活方式指导DOI: 10.1159/000550434 Eur J Endocrinol IF: 05.200Ahead of Print.No.59Quality of Life in Patients with Pheochromocytoma and Paraganglioma: Influence of Tumor Type, Genetics and Surgical Resection嗜铬细胞瘤和副神经节瘤患者的生活质量：肿瘤类型、遗传学和手术切除的影响DOI: 10.1093/ejendo/lvag003 Eur J Endocrinol IF: 05.200Ahead of Print.No.60Effects of GLP-1 Receptor Agonists on Copeptin in Euvolemic ParticipantsGLP-1受体激动剂对血容量正常参与者中肽素水平的影响DOI: 10.1093/ejendo/lvag005 J Clin Gastroenterol IF: 02.700Ahead of Print.No.61Metabolic Comorbidities and Hospital Outcomes in Patients With Inflammatory Bowel Disease: A Nationwide Analysis炎症性肠病患者的代谢合并症与住院结局：一项全国性分析DOI: 10.1097/MCG.0000000000002333 Am J Gastroenterol IF: 07.600Ahead of Print.No.62Postimaging Colorectal Cancer After Computed Tomography Colonography: A Danish Nationwide StudyCT结肠成像检查后的影像后结直肠癌：一项丹麦全国性研究DOI: 10.14309/ajg.0000000000003849 Diabetes care IF: 16.600Ahead of Print.No.63Empagliflozin in HNF1A-MODY (MODY3)-a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial恩格列净在HNF1A-MODY（MODY3）中的疗效——一项随机、双盲、安慰剂对照、交叉试验DOI: 10.2337/dc25-2572 Neurology IF: 08.500Volume 106, Issue 3No.64Development of a Prognostic Model for Poststroke Dementia Using Multiple International Cohorts: A STROKOG Collaboration Study利用多国队列开发卒中后痴呆预后模型：一项STROKOG合作研究DOI: 10.1212/WNL.0000000000214574 Diabetes IF: 07.500Ahead of Print.No.65Amino Acid Sensing by the α-Cell Mitochondrial Phosphoenolpyruvate Cycle Regulates Intracellular Ca2+ Levels Without Affecting Glucagon Secretionα细胞线粒体磷酸烯醇丙酮酸循环通过感知氨基酸调节细胞内钙离子水平而不影响胰高血糖素分泌DOI: 10.2337/db25-0510 La Clinica terapeuticaVolume 177, Issue 1No.66Intelligent Monitoring of Health Conditions in Patients with Diabetes in the Context of Healthcare Digitalization医疗数字化背景下糖尿病患者的智能健康监测DOI: 10.7417/CT.2026.1981 JAMA Internal Medicine IF: 23.300Ahead of Print.No.67High-Dose vs Standard-Dose Influenza Vaccine in Older Adults With Diabetes: A Secondary Analysis of the DANFLU-2 Randomized Clinical Trial高剂量与标准剂量流感疫苗在老年糖尿病患者中的比较：DANFLU-2随机临床试验的二次分析DOI: 10.1001/jamainternmed.2025.7286 JAMA Neurology IF: 21.300Ahead of Print.No.68Maternal Pregnancy Outcomes and Offspring Risk of Adult-Onset Multiple Sclerosis母亲妊娠结局与子代成人发病型多发性硬化症风险DOI: 10.1001/jamaneurol.2025.5255 Journal of behavioral medicine IF: 02.900Ahead of Print.No.69Diabetes Distress and Glycemic Stability: The Mediating Role of Experiential Avoidance and Disordered Eating in Type 1 Diabetes糖尿病相关心理压力与血糖稳定性：经验性回避与饮食失调在1型糖尿病中的中介作用DOI: 10.1007/s10865-025-00623-5 Cell biochemistry and biophysics IF: 02.500Ahead of Print.No.70Fisetin-loaded Nanoemulsion and Fecal Microbiome Extract Enhance In Vitro Inhibition of Non-Small Cell Lung Cancer Progression负载漆黄素的纳米乳剂与粪便微生物组提取物协同提升体外实验中对非小细胞肺癌进展的抑制效果DOI: 10.1007/s12013-025-01981-2 Pituitary IF: 03.400Volume 29, Issue 1No.71The impact of growth hormone (GH) on immunosenescence: exploring the role of B and T cells生长激素对免疫衰老的影响：探索B细胞和T细胞的作用DOI: 10.1007/s11102-025-01632-y Osteoporosis international IF: 05.400Ahead of Print.No.72Non-metastatic breast cancer patients discontinuing aromatase inhibitor on denosumab: what next?停用芳香化酶抑制剂并正在使用地舒单抗的非转移性乳腺癌患者：后续如何治疗？DOI: 10.1007/s00198-025-07798-2 Osteoporosis international IF: 05.400Ahead of Print.No.73Post-fracture care and predictors of anti-osteoporotic treatment in Switzerland: a nationwide health claims analysis瑞士骨折后护理及抗骨质疏松治疗预测因素：一项全国性健康索赔数据分析DOI: 10.1007/s00198-025-07832-3 J Asian Nat Prod Res IF: 01.300Ahead of Print.No.74Methyl jasmonate protects liver and pancreas tissues of adult diabetic rats from STZ-induced oxidative stress damage茉莉酸甲酯保护成年糖尿病大鼠的肝脏和胰腺组织免受STZ诱导的氧化应激损伤DOI: 10.1080/10286020.2025.2611910 Endocrine-related cancer IF: 04.600Ahead of Print.No.75Prevalence and Clinical Characteristics of Lynch Syndrome-associated Adrenocortical Carcinoma林奇综合征相关肾上腺皮质癌的患病率与临床特征DOI: 10.1530/ERC-25-0389 Aging cell IF: 07.100Volume 25, Issue 2No.76Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage雷帕霉素通过增强对DNA损伤的抵抗力，在衰老的人类免疫系统中发挥其延缓衰老的作用DOI: 10.1111/acel.70364 Clinical toxicology IF: 03.300Ahead of Print.No.77A retrospective study of centipede bites in Guadeloupe, West Indies: epidemiology, medical and surgical management法属瓜德罗普岛蜈蚣咬伤回顾性研究：流行病学特征及内外科处理DOI: 10.1080/15563650.2025.2591338 Organic & biomolecular chemistry IF: 02.700Ahead of Print.No.78C(3)-H alkenylation of quinoxalin-2(1H)-ones with Hantzsch esters and in silico studies利用Hantzsch酯对喹喔啉-2(1H)-酮进行C(3)-H烯基化反应及计算机模拟研究DOI: 10.1039/d5ob01795e Journal of molecular histology IF: 02.200Volume 57, Issue 1No.79Combined effects of chronic high glucose and fluoride exposure on kidney cells: exploratory in vitro and in vivo study慢性高糖与氟化物暴露对肾脏细胞的联合效应：一项探索性的体外与体内研究DOI: 10.1007/s10735-025-10670-6 Archives of osteoporosis IF: 02.800Volume 21, Issue 1No.80Utility of diffusion tensor imaging for assessing bone quality in type 2 diabetes: correlation with bone turnover biomarkers扩散张量成像评估2型糖尿病骨质量的效用：与骨转换生物标志物的相关性DOI: 10.1007/s11657-025-01643-z La Clinica terapeuticaVolume 177, Issue 1No.81Determinants of Non-Adherence to the Mediterranean Diet Among Healthcare Workers: A cross-sectional study医护人员不坚持地中海饮食的决定因素：一项横断面研究DOI: 10.7417/CT.2026.1985 European journal of nutrition IF: 04.300Volume 65, Issue 1No.82Can vegetables intake pattern mediate the relationship between fast-food and cognitive performance in adolescents? The Cogni-Action project蔬菜摄入模式在快餐与青少年认知表现关系中的中介作用：Cogni-Action项目DOI: 10.1007/s00394-025-03884-7 Journal of endocrinology IF: 03.900Ahead of Print.No.83Fat's All, Folks: Culturing and Manipulating Peri-Prostatic Adipocytes to Probe Impacts on Prostate Cancer Biology脂肪的奥秘：培养与操纵前列腺周围脂肪细胞以探究其对前列腺癌生物学的影响DOI: 10.1530/JOE-25-0256 European Journal of Immunology IF: 03.700Volume 56, Issue 1No.84The Increased Secretion of Lactate Observed in Obesity and Aging Leads to the Generation of Pathogenic B Cells肥胖和衰老中观察到的乳酸分泌增加导致致病性B细胞的产生DOI: 10.1002/eji.70120 Chronobiology international IF: 01.700Ahead of Print.No.85Light matters: Investigating the influence of natural and artificial light on BMI and key mediators光线的重要性：调查自然光与人工光对BMI及其关键中介因素的影响DOI: 10.1080/07420528.2025.2606281 Cutaneous and ocular toxicology IF: 01.300Ahead of Print.No.86Alternative models for evaluation of ocular toxicological effects of environmental chemicals and pharmaceuticals: a review评估环境化学品与药物眼毒性效应的替代模型：一篇综述DOI: 10.1080/15569527.2025.2607700 Abdominal radiology IF: 02.200Ahead of Print.No.87AI for screening in healthcare: promise and challenges人工智能在医疗筛查中的应用：前景与挑战DOI: 10.1007/s00261-025-05370-4 North Carolina medical journalVolume 86, Issue 3No.88Barriers to Care in Hispanic American Patients with Diabetic Retinopathy西班牙裔美国糖尿病视网膜病变患者面临的护理障碍DOI: 10.18043/001c.143309 J Gerontol B Psychol Sci Soc Sci IF: 03.200Volume 81, Issue 2No.89Heterogeneity in Asian Americans' mortality trends, 2000-2022亚裔美国人死亡率趋势的异质性：2000-2022年DOI: 10.1093/geronb/gbaf248 Current microbiology IF: 02.600Volume 83, Issue 2No.90Green Synthesis and Bioactivity Evaluation of Silver Nanoparticles from Stevia rebaudiana and the Endophyte Aspergillus versicolor利用甜叶菊及其内生真菌泡盛曲霉绿色合成银纳米颗粒及其生物活性评估DOI: 10.1007/s00284-025-04712-1 JAMA Network Open IF: 09.700Volume 9, Issue 1No.91Volunteering and Metabolic Syndrome and Diabetes in Black Adolescents From Low-Income Families志愿服务与低收入家庭黑人青少年的代谢综合征和糖尿病DOI: 10.1001/jamanetworkopen.2025.53419 Minerva anestesiologica IF: 02.800Ahead of Print.No.92Pregabalin versus dexmedetomidine for postoperative delirium in cardiac surgery: a pragmatic step forward?普瑞巴林与右美托咪定用于心脏手术后谵妄：一项务实的进步？DOI: 10.23736/S0375-9393.25.19648-X Expert Rev Pharmacoecon Outcomes Res IF: 01.500Ahead of Print.No.93Real-world healthcare resource utilization and medical costs in patients with overweight or obesity and multimorbidity treated with semaglutide in the United States美国超重或肥胖合并多重共病患者使用司美格鲁肽的真实世界医疗资源利用与医疗成本分析DOI: 10.1080/14737167.2025.2610206 Neurological sciences IF: 02.400Volume 47, Issue 1No.94The effect of GLP-1 receptor agonists on cognition in nondiabetic patients with mild cognitive impairment or alzheimer's disease: a meta-analysis of randomized controlled trialsGLP-1受体激动剂对非糖尿病轻度认知障碍或阿尔茨海默病患者认知功能影响的荟萃分析DOI: 10.1007/s10072-025-08602-z Tremor Other Hyperkinet Mov (N Y) IF: 02.100Volume 16, Issue No.95Proceedings of the 12(th) International Meeting on Neuroacanthocytosis, Cohen Syndrome, and Other VPS13-Related Disorders第12届神经棘红细胞增多症、Cohen综合征及其他VPS13相关疾病国际会议纪要DOI: 10.5334/tohm.1124 Drugs - real world outcomes IF: 01.900Ahead of Print.No.96Trends in Adverse Event Reports of Dipeptidyl Peptidase-4 Inhibitor-Associated Pemphigoid in Japan日本二肽基肽酶-4抑制剂相关性天疱疮不良事件报告趋势DOI: 10.1007/s40801-025-00535-5 J Cardiovasc Med IF: 02.000Ahead of Print.No.97Hypokinetic nondilated cardiomyopathy: clinical characteristics, prognosis, and therapy response compared to dilated cardiomyopathy相比扩张型心肌病，非扩张性低动力性心肌病的临床特征、预后和治疗反应DOI: 10.2459/JCM.0000000000001813 La Clinica terapeuticaVolume 177, Issue 1No.98Metabolic and Hormonal Impact of Subclinical Hypothyroidism in Women with Polycystic Ovary Syndrome: A Cross-Sectional Study from South India印度南部多囊卵巢综合征女性中亚临床甲状腺功能减退症的代谢与激素影响：一项横断面研究DOI: 10.7417/CT.2026.1983 Am J Physiol Cell Physiol IF: 04.700Ahead of Print.No.99Ablation of Tumor-Derived IGFBP-3 Attenuates Cancer-Associated Skeletal Muscle Wasting in Murine Pancreatic Cancer敲除肿瘤来源的IGFBP-3可减轻小鼠胰腺癌相关的骨骼肌消耗DOI: 10.1152/ajpcell.00421.2025 Diabetes IF: 07.500Ahead of Print.No.100GLP-1, Pancreatic β-Cells, and Insulin Secretion: What We Know and Where We Need to GoGLP-1、胰腺β细胞与胰岛素分泌：已知与待探索DOI: 10.2337/db25-0695 Diabetes IF: 07.500Ahead of Print.No.101Identifying Insulin Autoantibodies With Differential Risk in Type 1 Diabetes With a Novel Bridging ELISA利用新型桥接酶联免疫吸附法鉴定具有不同风险的1型糖尿病胰岛素自身抗体DOI: 10.2337/db25-0696 Pituitary IF: 03.400Volume 29, Issue 1No.102Comparison of oral versus intravenous glucose exposure on plasma growth hormone levels: a crossover study in healthy volunteers口服与静脉葡萄糖暴露对血浆生长激素水平的比较：一项健康志愿者的交叉研究DOI: 10.1007/s11102-025-01633-x Molecular neurobiology IF: 04.300Volume 63, Issue 1No.103Valacyclovir Mitigates Amyloid Plaque Deposition, P-Tau Aggregation, and Neuroinflammation in Streptozotocin induced Alzheimer's Disease Rat Model伐昔洛韦减轻链脲佐菌素诱导的阿尔茨海默病大鼠模型中的淀粉样斑块沉积、p-Tau聚集及神经炎症DOI: 10.1007/s12035-025-05652-4 Nutrition reviews IF: 04.900Ahead of Print.No.104The Effects of Probiotic Supplementation on Bisphenol A Toxicity: A Systematic Literature Review益生菌补充对双酚A毒性的影响：一项系统文献综述DOI: 10.1093/nutrit/nuaf272 Adv Clin Exp Med IF: 01.900Ahead of Print.No.105Simple, low-cost in vitro protocol for differentiating mesenchymal stem cells into cardiomyocyte-like cells将间充质干细胞分化为心肌细胞样细胞的简单、低成本体外方案DOI: 10.17219/acem/204112 J Am Nutr Assoc IF: 02.600Ahead of Print.No.106Effects of Brassica juncea Seed Extract on Diabetes-Related Gene Expression Profiling of Pancreatic β-Cells in a Rat Model: Relevance to Environmental and Health Safety芥菜籽提取物对大鼠模型胰腺β细胞糖尿病相关基因表达谱的影响：与环境和健康安全的相关性DOI: 10.1080/27697061.2025.2596999 Zh Nevrol Psikhiatr Im S S KorsakovaVolume 125, Issue 12No.107[Relationship of glycemic, metabolic, immuno-inflammatory, and psychopathological parameters in patients with depressive disorder: a retrospective analysis]抑郁障碍患者血糖、代谢、免疫炎症及精神病理参数的相关性：一项回顾性分析DOI: 10.17116/jnevro2025125121223 Biologie aujourd'huiVolume 219, Issue 3-4No.108[Popular myths vs. physiological realities: The rehabilitation of lactate]流行误解 vs. 生理现实：乳酸的平反DOI: 10.1051/jbio/2025010 Am J Med Qual IF: 01.300Ahead of Print.No.109Determining Causes of Insulin-Induced Hypoglycemia Using an Electronic-Based Trigger使用电子触发器确定胰岛素诱导低血糖的原因DOI: 10.1097/JMQ.0000000000000280 World J Exp MedVolume 15, Issue 3No.110Clinical significance of differential plasma proteins levels in the diagnosis of epithelial ovarian cancer差异血浆蛋白水平在上皮性卵巢癌诊断中的临床意义DOI: 10.5493/wjem.v15.i3.107711 FASEB bioAdvances IF: 02.000Volume 8, Issue 1No.111The Gut Microbiota-Insulin Resistance Axis: Mechanisms, Clinical Implications, and Therapeutic Potential肠道菌群-胰岛素抵抗轴：机制、临床意义与治疗潜力DOI: 10.1096/fba.2025-00218 Translational sports medicineVolume 2026, Issue No.112Associations Between Handgrip Strength and Markers of Insulin Resistance and Inflammation in Childhood and Adolescence: A Systematic Review With Meta-Analysis儿童青少年握力与胰岛素抵抗及炎症标志物关联性：系统综述与荟萃分析DOI: 10.1155/tsm2/1091342 Diabetes spectrumVolume 38, Issue 5No.113Racial Disparities in the Use of Automated Insulin Delivery Systems in Youth With Type 1 Diabetes青少年1型糖尿病患者中自动胰岛素输送系统使用的种族差异DOI: 10.2337/ds25-0023 Diabetes spectrumVolume 38, Issue 5No.114Observations of Glucagon-Prescribing Patterns for High-Risk People With Diabetes Within a Federally Qualified Health Center在一家联邦合格医疗中心内对高风险糖尿病患者胰高血糖素处方模式的观察DOI: 10.2337/ds25-0044 Diabetes spectrumVolume 38, Issue 5No.115Factors Considered Important by Diabetes Providers Before Recommending Automated Insulin Delivery Systems: Observations From the T1D Exchange Quality Improvement Collaborative糖尿病提供者在推荐自动胰岛素输送系统前考虑的重要因素：来自T1D Exchange质量改进协作组的观察DOI: 10.2337/ds25-0009 Case reports in nephrologyVolume 2026, Issue No.116A Case of Post-Transplantation Lymphoproliferative Disorder Following Kidney Transplantation肾移植后移植后淋巴组织增生性疾病一例DOI: 10.1155/crin/5917161 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.117The spectrum of exogenous insulin requirement in people living with type 1 diabetes: A cross-sectional analysis1型糖尿病患者外源性胰岛素需求谱：一项横断面分析DOI: 10.1111/dom.70467 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.118Long-acting insulin analogues and the risk of diabetic nephropathy among patients with type 2 diabetes: A population-based cohort study长效胰岛素类似物与2型糖尿病患者糖尿病肾病风险：一项基于人群的队列研究DOI: 10.1111/dom.70397 Development IF: 03.600Ahead of Print.No.119Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the C. elegans germ line前滞育期饥饿快速且可逆地降低秀丽隐杆线虫生殖系的微环境增殖信号DOI: 10.1242/dev.204972 JCRPE IF: 01.500Ahead of Print.No.120The Relationship Between HbA1c and GMI and Glucose Metrics in Children and Adolescents with Type 1 Diabetes Using AID儿童与青少年1型糖尿病患者使用自动化胰岛素输注系统时HbA1c、GMI与血糖指标间的关系DOI: 10.4274/jcrpe.galenos.2025.2025-10-11 Journal of materials chemistry IF: 05.700Ahead of Print.No.121Surfactin-inspired arginine- and lysine-rich peptides inhibit human insulin aggregation and prevent amyloid-induced cytotoxicity受表面活性素启发的富含精氨酸与赖氨酸多肽抑制人胰岛素聚集并防止淀粉样蛋白诱导的细胞毒性DOI: 10.1039/d5tb01952d Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 1No.122Serum Uric Acid as a Mediator of Insulin Resistance: Molecular Mechanisms and Metabolic Pathways血清尿酸：胰岛素抵抗的潜在介导者及其分子机制与代谢通路DOI: 10.1002/edm2.70163 Nursing standardAhead of Print.No.123Recognising, managing and reducing the risk of hypoglycaemia in adults with diabetes成人糖尿病患者低血糖风险的识别、管理与降低DOI: 10.7748/ns.2026.e12574 J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.124Insulin Receptor Family Autoantibodies in Patients with Type B insulin ResistanceB型胰岛素抵抗患者的胰岛素受体家族自身抗体DOI: 10.1210/clinem/dgaf692 Ther Adv Psychopharmacol IF: 04.000Volume 16, Issue No.125A description of antipsychotic prescribing patterns on the inpatient behavioral health setting: a multicenter cross-sectional analysis住院行为健康环境中抗精神病药物处方模式的描述：一项多中心横断面分析DOI: 10.1177/20451253251394296 World J Exp MedVolume 15, Issue 3No.126Effect of propolis and honey in hyperglycemia-induced kidney and liver injuries, proteinuria, and oxidant and antioxidant parameters蜂胶与蜂蜜对高血糖所致肾肝损伤、蛋白尿及氧化与抗氧化参数的影响DOI: 10.5493/wjem.v15.i3.99330 World J Exp MedVolume 15, Issue 3No.127Relationship of diabetes mellitus with prognostic factors in breast cancer糖尿病与乳腺癌预后因素的关系DOI: 10.5493/wjem.v15.i3.108318 Int J Endocrinol IF: 02.300Volume 2026, Issue No.128Correction to "Astaxanthin Modulates Inflammation in Type 2 Diabetes via Regulation of microRNAs, Lysophosphatidylcholine, and α-Hydroxybutyrate"《虾青素通过调控微小RNA、溶血磷脂酰胆碱和α-羟基丁酸调节2型糖尿病炎症》一文更正DOI: 10.1155/ije/9845896 Ther Adv Endocrinol Metab IF: 04.600Volume 17, Issue No.129Accuracy and feasibility of real-time continuous glucose monitoring in early postoperative intensive care after liver transplantation肝移植术后早期重症监护中实时连续血糖监测的准确性与可行性DOI: 10.1177/20420188251405372 Curēus IF: 01.300Volume 17, Issue 12No.130Shewanella algae as a Rare Cause of Bullous Cellulitis and Sepsis: The First Reported Case in Lithuania希瓦氏藻作为大疱性蜂窝织炎和脓毒症的罕见病因：立陶宛首例报告病例DOI: 10.7759/cureus.98958 Curēus IF: 01.300Volume 17, Issue 12No.131A Rare Case of Parathyroid Carcinoma Initially Misdiagnosed as a Parathyroid Adenoma一例最初被误诊为甲状旁腺腺瘤的罕见甲状旁腺癌病例DOI: 10.7759/cureus.98794 Curēus IF: 01.300Volume 17, Issue 12No.132Impact of Long-Term Glucocorticoid Therapy on the Response to Biologic Agents in Rheumatoid Arthritis: A Prospective Observational Study长期糖皮质激素治疗对类风湿关节炎生物制剂疗效的影响：一项前瞻性观察研究DOI: 10.7759/cureus.98824 Curēus IF: 01.300Volume 17, Issue 12No.133Functional Magnetic Resonance Imaging (fMRI) and Music Therapy for Concussion: A Case Report功能性磁共振成像与音乐疗法治疗脑震荡：一例病例报告DOI: 10.7759/cureus.98823 Curēus IF: 01.300Volume 17, Issue 12No.134Neutrophil-to-Lymphocyte Ratio Correlation With the Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery (SYNTAX) Score in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome中性粒细胞与淋巴细胞比值与非ST段抬高型急性冠状动脉综合征患者SYNTAX评分的相关性DOI: 10.7759/cureus.98890 Curēus IF: 01.300Volume 17, Issue 12No.135Outcomes of Free Flap Surgery in Head and Neck Cancer Patients With Chronic Kidney Disease: A Single-Institution Retrospective Study of 61 Cases慢性肾脏病头颈癌患者游离皮瓣手术结局：61例单中心回顾性研究DOI: 10.7759/cureus.98897 Curēus IF: 01.300Volume 17, Issue 12No.136Atypical Presentation of Chronic Left Anterior Descending Occlusion: Heart Failure Without Angina as the Initial Manifestation慢性左前降支闭塞的不典型表现：心力衰竭作为首发症状而无心绞痛DOI: 10.7759/cureus.98903 Curēus IF: 01.300Volume 17, Issue 12No.137Late-Onset NR0B1-Related Adrenal Hypoplasia Congenita Presenting With Primary Adrenal Insufficiency and Pubertal Delay表现为原发性肾上腺皮质功能减退症和青春期延迟的迟发性NR0B1相关性先天性肾上腺发育不全DOI: 10.7759/cureus.98859 Indian J Radiol ImagingVolume 36, Issue 1No.138Spectrum of Typical and Atypical Imaging Findings and Pathological Features in Diabetic Mastopathy糖尿病性乳腺病的典型与非典型影像学表现及病理特征的谱系分析DOI: 10.1055/s-0045-1808258 J Curr Glaucoma PractVolume 19, Issue 4No.139The Influence of Hemodialysis on Ocular Pressure Dynamics: An Observational Study on IOP and OPP Changes血液透析对眼压动态的影响：一项关于IOP和OPP变化的观察性研究DOI: 10.5005/jp-journals-10078-1497 J Curr Glaucoma PractVolume 19, Issue 4No.140Glaucoma Risk Reduction as a Secondary Benefit of Glucagon-like Peptide-1 Receptor Agonists: A Review of Emerging Evidence胰高血糖素样肽-1受体激动剂降低青光眼风险作为次要获益：新兴证据综述DOI: 10.5005/jp-journals-10078-1501 Am J Lifestyle Med IF: 01.300Ahead of Print.No.141Lifestyle Interventions for Major Depressive Disorder (MDD): An Expert Consensus Statement From the American College of Lifestyle Medicine生活方式干预治疗重性抑郁障碍（MDD）：来自美国生活方式医学会的专家共识声明DOI: 10.1177/15598276251408353 F1000ResearchVolume 13, Issue No.142Molecular Characterization of Dermatophyte species from rural tertiary care hospital: A Study Protocol农村三级医院皮肤癣菌的分子特征研究：一项研究方案DOI: 10.12688/f1000research.141657.4 J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.143A Study to Asses Effects of Diabetes Mellitus on Treatment Outcome of Tuberculosis Patients一项评估糖尿病对结核病患者治疗结局影响的研究DOI: 10.4103/jpbs.jpbs_1425_25 J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.144Correlation of Candida Species and Carriage in Uncontrolled and Controlled Diabetics on Various Oral Hypoglycemic Drug Regimen不同口服降糖药方案下控制与非控制糖尿病患者口腔念珠菌定植及其菌种相关性研究DOI: 10.4103/jpbs.jpbs_1372_25 J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.145Awareness, Perception, and Knowledge about Oral Microbiota among College of Dentistry Students in Gulf Medical University/United Arab Emirates阿拉伯联合酋长国海湾医科大学牙科学院学生对口腔微生物群的认知、理解及知识现状DOI: 10.4103/jpbs.jpbs_1161_25 J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.146Comparison of Extraction Socket Healing in Patients with Type 2 Diabetes on Oral Hypoglycemics Versus Nondiabetic-Original Research口服降糖药治疗的2型糖尿病患者与非糖尿病患者拔牙创愈合情况比较DOI: 10.4103/jpbs.jpbs_1240_25 J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.147Periodontal Status of Medically Compromised Patients Visiting Teaching Hospitals in Riyadh City: A Retrospective Study利雅得市教学医院就诊的全身性疾病患者的牙周状况：一项回顾性研究DOI: 10.4103/jpbs.jpbs_1269_25 J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.148Association Between Serum Vitamin D Levels and Glycemic Status in Prediabetic Adults糖尿病前期成人血清维生素D水平与血糖状态之间的关联DOI: 10.4103/jpbs.jpbs_1112_25 Ther Adv Drug Saf IF: 03.400Volume 17, Issue No.149Safety and risk management in clinical trials for chronic wounds with tissue regenerative products使用组织再生产品的慢性伤口临床试验中的安全性与风险管理DOI: 10.1177/20420986251385861 JBMR plus IF: 02.400Volume 10, Issue 2No.150Denosumab as a treatment for pediatric hypercalcemia-a multicenter experienceDenosumab作为儿童高钙血症的治疗：一项多中心经验DOI: 10.1093/jbmrpl/ziaf171 J Educ Teach Emerg MedVolume 10, Issue 5No.151Managing Conflict Case: Admission of a Patient with Decompensated Schizophrenia, Hypertension, and Diabetes冲突管理案例：一例失代偿性精神分裂症、高血压和糖尿病患者入院争议的化解DOI: 10.21980/J8.52341 J Pharm Bioallied Sci IF: 00.700Volume 17, Issue 4No.152Spectrum of Deep Neck Space Abscesses: A Case Series Experience in a Tertiary Health Care Centre深颈部间隙脓肿类型谱：一家三级医疗中心的病例系列经验DOI: 10.4103/jpbs.jpbs_1490_25 Int J Biol Sci IF: 10.000Volume 22, Issue 2No.153Impact of rare JAK/STAT germline mutations on vaccination-induced innate immune responses in a Tyrolian population罕见JAK/STAT种系突变对蒂罗尔人群疫苗接种诱导先天免疫应答的影响DOI: 10.7150/ijbs.124098 Plastic surgery IF: 00.600Ahead of Print.No.154Treatment of Critical Hand Ischemia Due to Mycotic Aneurysm of Radial and Ulnar Arteries: A Case Report桡动脉与尺动脉真菌性动脉瘤所致危重手部缺血的治疗：病例报告DOI: 10.1177/22925503251411863 Journal of diabetes research IF: 03.400Volume 2026, Issue No.155Association Between Sodium-Glucose Cotransporter-2 Inhibitors and Sepsis Risk in Patients With Type 2 Diabetes Mellitus钠-葡萄糖协同转运蛋白2抑制剂与2型糖尿病患者脓毒症风险的相关性研究DOI: 10.1155/jdr/1437417 Curēus IF: 01.300Volume 17, Issue 12No.156Lifestyle Behavioral Self-Care Practices and Their Determinants Among Type 2 Diabetes Patients Attending a Non-communicable Disease Clinic in Agra District: A Cross-Sectional Study印度阿格拉地区非传染性疾病诊所2型糖尿病患者的生活方式行为自我护理实践及其决定因素：一项横断面研究DOI: 10.7759/cureus.98857 Avicenna J Med BiotechnolVolume 17, Issue 3No.157Ameliorating Potential of Quercetin and Curcumin on Glucose-6-Phosphate Dehydrogenase Expression via miRNAs in Rats with Type 2 Diabetes Mellitus槲皮素与姜黄素通过miRNAs改善2型糖尿病大鼠葡萄糖-6-磷酸脱氢酶表达的潜力DOI: 10.18502/ajmb.v17i3.19280 J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.158Evaluation of Hematological Changes in Type 2 Diabetes Mellitus and Their Correlation with Glycemic Control评估2型糖尿病患者的血液学变化及其与血糖控制的相关性DOI: 10.4103/jpbs.jpbs_1111_25 J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.159A Cross-sectional Study of Awareness about Diabetes Mellitus and its Complications among Indian Patients with Type 2 Diabetes Mellitus印度2型糖尿病患者对糖尿病及其并发症认知度的横断面研究DOI: 10.4103/jpbs.jpbs_1417_25 J Diabetes Metab Disord IF: 01.600Volume 25, Issue 1No.160Genetic susceptibility to type 2 diabetes: Insights from a comprehensive meta-analysis of FABP2 polymorphisms2型糖尿病的遗传易感性：基于FABP2基因多态性的全面荟萃分析启示DOI: 10.1007/s40200-025-01847-7 J Diabetes Metab Disord IF: 01.600Volume 25, Issue 1No.161GLP-1 receptor agonists in kidney transplant recipients with type 2 diabetes mellitus: a systematic review and meta-analysis on mortality and major adverse kidney eventsGLP-1受体激动剂在合并2型糖尿病的肾移植受者中的应用：一项关于死亡率和主要不良肾脏事件的系统综述与荟萃分析DOI: 10.1007/s40200-025-01801-7 Aging cell IF: 07.100Volume 25, Issue 2No.162Frequently Reported Blood Biomarkers in Sarcopenia Clinical Trials: A Systematic Review and Meta-Analysis肌肉减少症临床试验中常报告的血源性生物标志物：一项系统综述与荟萃分析DOI: 10.1111/acel.70361 Curēus IF: 01.300Volume 18, Issue 1No.163Sight Unseen: Glucagon-Like Peptide-1 (GLP-1) Agonism Therapy and Nonarteritic Anterior Ischemic Optic Neuropathy视而不见：胰高血糖素样肽-1（GLP-1）激动剂治疗与非动脉炎性前部缺血性视神经病变DOI: 10.7759/cureus.100953 NPJ biomedical innovationsVolume 3, Issue 1No.164Decoding wound healing: cellular insights and technological advances解码伤口愈合：细胞见解与技术进展DOI: 10.1038/s44385-025-00046-6 Curēus IF: 01.300Volume 17, Issue 12No.165Panhypopituitarism Secondary to a Central Nervous System Germinoma继发于中枢神经系统生殖细胞瘤的全垂体功能减退症DOI: 10.7759/cureus.98887 Scientifica IF: 03.100Volume 2025, Issue No.166Characterization of Unsaponifiable Matter in Unripe Pistacia atlantica Fruits: Evaluation of Antioxidant Activity and α-Amylase Inhibitory Effect未成熟大西洋黄连木果实中不皂化物的表征：抗氧化活性与α-淀粉酶抑制效应评估DOI: 10.1155/sci5/8016775 NAR molecular medicineVolume 3, Issue 1No.167Combination of vemurafenib, pleconaril, and AG7404 attenuates enterovirus replication in vitro and in vivo维莫非尼、普莱康纳利与AG7404三联疗法在体外和体内抑制肠道病毒复制DOI: 10.1093/narmme/ugaf046 J Gastrointest Oncol IF: 02.000Volume 16, Issue 6No.168Hypercalcemia in metastatic pancreatic neuroendocrine tumor: a case report of ectopic 1,25 hydroxyvitamin D production by tumor cells and tumor-associated macrophages转移性胰腺神经内分泌肿瘤致高钙血症一例：肿瘤细胞与肿瘤相关巨噬细胞的1,25二羟基维生素D异位生成DOI: 10.21037/jgo-2025-616 Curēus IF: 01.300Volume 18, Issue 1No.169Comparative Effectiveness of Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors Versus Glucagon-Like Peptide-1 (GLP-1) Agonists on Cardiovascular and Renal Outcomes in Type 2 Diabetes: A Systematic Review and Network Meta-Analysis钠-葡萄糖协同转运蛋白2抑制剂与胰高血糖素样肽-1受体激动剂对2型糖尿病患者心血管及肾脏结局的疗效比较：一项系统综述与网络荟萃分析DOI: 10.7759/cureus.100927 Dermatol Res Pract IF: 01.900Volume 2026, Issue No.170Prurigo Pigmentosa Following Bariatric Surgery: A Comprehensive Clinicopathological Review减重手术后发生的色素性痒疹：一项综合临床病理学回顾DOI: 10.1155/drp/1993385 Diabetes spectrumVolume 38, Issue 5No.171Population Screening for Type 1 Diabetes in Pediatrics via Well-Child Visits: Barriers and Facilitators to Implementation通过儿童健康体检进行儿科1型糖尿病普遍筛查：实施障碍与促进因素DOI: 10.2337/ds25-0036 Diabetes spectrumVolume 38, Issue 5No.172Psychological Impact of Type 1 Diabetes: A Focus on Disordered Eating Behavior in Female Adolescents1型糖尿病的心理影响：聚焦女性青少年的饮食失调行为DOI: 10.2337/ds25-0001 Pediatric allergy and immunology IF: 04.500Volume 37, Issue 1No.173Food protein-induced enterocolitis syndrome in children: A swiss prospective multicenter study儿童食物蛋白诱导性肠炎综合征：一项瑞士前瞻性多中心研究DOI: 10.1111/pai.70279 Int J Ophthalmol IF: 01.800Volume 19, Issue 1No.174Intraocular inflammation after intravitreal injection of faricimab-a case series including one case of bilateral choroidal involvement玻璃体内注射法瑞西单抗后的眼内炎症——包含一例双侧脉络膜受累的病例系列DOI: 10.18240/ijo.2026.01.23 Int J Ophthalmol IF: 01.800Volume 19, Issue 1No.175Management of coexisting cataract and diabetic macular edema: a comparative study of dexamethasone implant versus anti-VEGF agents injections合并白内障与糖尿病性黄斑水肿的治疗：地塞米松植入剂对比抗VEGF药物注射的比较研究DOI: 10.18240/ijo.2026.01.07 Malaysian family physicianVolume 20, Issue No.176A scoping review of digital health applications for managing noncommunicable diseases in primary care post-pandemic: Lessons from the Western Pacific Region大流行后初级保健中非传染性疾病管理的数字健康应用范围综述：来自西太平洋地区的经验DOI: 10.51866/rv.919 Circulation reports IF: 01.100Volume 8, Issue 1No.177Pulse Rate Variability and All-Cause Mortality Risk in the General Japanese Population脉率变异性与日本一般人群全因死亡风险DOI: 10.1253/circrep.CR-25-0193 Plast Reconstr Surg Glob Open IF: 01.800Volume 14, Issue 1No.178Perineal Verrucous Carcinoma Associated With Hypercalcemia: First Clinical Report of Parathyroid Hormone-Related Protein-producing Tumor与高钙血症相关的会阴部疣状癌：甲状旁腺激素相关蛋白产生性肿瘤的临床报告DOI: 10.1097/GOX.0000000000007395 Health science reports IF: 02.100Volume 9, Issue 1No.179The Role of Health-Related Factors in the Prevalence and Severity of COVID-19: A Retrospective Cohort Study Based on Sabzevar Persian Cohort Data健康相关因素在COVID-19患病率和严重程度中的作用：基于Sabzevar波斯队列数据的回顾性队列研究DOI: 10.1002/hsr2.71709 Expert opinion on drug delivery IF: 05.400Ahead of Print.No.180Application of iron oxide nanoparticles in liver drug delivery: insights into biodegradation and toxicity at cellular, tissue, and organ levels铁氧化物纳米颗粒在肝脏药物递送中的应用：从细胞、组织到器官层面的生物降解与毒性见解DOI: 10.1080/17425247.2026.2613932 RC IF: 01.300Volume 26, Issue 12No.181The Beneficial Effects of Glucagon-Like Peptide-1 Agonists on Blood Pressure: A Comprehensive Review胰高血糖素样肽-1受体激动剂对血压的有益影响：全面综述DOI: 10.31083/RCM45204 Korean J Community NutrVolume 28, Issue 6No.182[Process evaluation of a mobile healthcare program among employees with overweight and obesity: a 12-week intervention study investigating the role of engagement]超重和肥胖员工移动健康计划的过程评估：一项探讨参与度作用的12周干预研究DOI: 10.5720/kjcn.2023.28.6.466 Obesity science & practice IF: 01.900Volume 12, Issue 1No.183A Cross-Sectional Study Investigating the Relationship Between the FTO Gene Polymorphism in Relation to Obesity Traits and Vitamin D Status in AdolescenceFTO基因多态性与青少年肥胖特征及维生素D状态关系的横断面研究DOI: 10.1002/osp4.70112 Korean J Community NutrVolume 28, Issue 2No.184Changes in dietary habits and chronic diseases before and after COVID-19 by regions using data from the 2018-2020 Korea Community Health Survey and Consumer Behavior Survey for Foods: a cross-sectional study基于韩国社区健康调查与食品消费行为调查数据：COVID-19前后不同地区饮食习惯与慢性疾病的变化DOI: 10.5720/kjcn.2023.28.2.124 Korean J Community NutrVolume 28, Issue 2No.185Effectiveness of a mobile health intervention on weight loss and dietary behavior changes among employees with overweight and obesity: a 12-week intervention study investigating the role of engagement移动健康干预对超重肥胖员工体重减轻及饮食行为改变的效果：一项为期12周的干预研究探究参与度作用DOI: 10.5720/kjcn.2023.28.2.141 World J Exp MedVolume 15, Issue 3No.186Glucagon-like peptide and its receptor agonists for the treatment of rheumatic diseases胰高血糖素样肽-1及其受体激动剂用于治疗风湿性疾病DOI: 10.5493/wjem.v15.i3.107020 World J Exp MedVolume 15, Issue 3No.187Potential role of nanopharmacology in reducing neuroinflammation associated with hypertension and metabolic disorders纳米药理学在减轻高血压与代谢紊乱相关神经炎症中的潜在作用DOI: 10.5493/wjem.v15.i3.106743 Int J Nephrol IF: 01.400Volume 2026, Issue No.188Chronic Kidney Disease and Superimposed Acute Kidney Injury: Greater Impact of Acute Insults on Outcomes慢性肾脏病与并发急性肾损伤：急性打击对结局影响更甚DOI: 10.1155/ijne/1353892 Food Science and Biotechnology IF: 03.100Volume 35, Issue 1No.189Anti-obesity effect of Bifidobacterium adolescentis SPM2022, isolated from Korean adult来自韩国成人的青春双歧杆菌SPM2022的抗肥胖效应DOI: 10.1007/s10068-025-02013-8 JB & JS open access IF: 03.800Volume 11, Issue 1No.190Weight and Infantile Blount Disease: Insights from a Rural Ghanaian Cohort体重与婴儿布朗特病：来自加纳农村队列的启示DOI: 10.2106/JBJS.OA.25.00310 Curēus IF: 01.300Volume 17, Issue 12No.191Measuring Adipocytokines in Young Patients With Type 2 Diabetes Presenting to a Tertiary Care Centre in Upper Assam, India测量印度上阿萨姆地区三级医疗中心就诊的年轻2型糖尿病患者的脂肪细胞因子DOI: 10.7759/cureus.98779 Curēus IF: 01.300Volume 17, Issue 12No.192Severe Small-Bowel Obstruction in a High-Risk Patient on Long-Term Tirzepatide Therapy: A Case Report长期替尔泊肽治疗的高风险患者发生严重小肠梗阻：病例报告DOI: 10.7759/cureus.98935 Curēus IF: 01.300Volume 17, Issue 12No.193Revisiting Jenkins' Rule: Evidence-Based Insights on the Suture-to-Wound Length Ratio and Wound Dehiscence重温Jenkins规则：关于缝线长度与伤口长度比例及伤口裂开的循证见解DOI: 10.7759/cureus.98942 Curēus IF: 01.300Volume 17, Issue 12No.194Ulcer Perforation on Excluded Stomach Following Gastric Bypass Surgery: A Case Report of Atypical Presentation Without Pneumoperitoneum胃旁路术后胃囊袋溃疡穿孔：一例无气腹不典型表现病例报告DOI: 10.7759/cureus.98785 Curēus IF: 01.300Volume 17, Issue 12No.195Pregnancy After Bariatric Surgery: Hepatobiliary Implications, Maternal Outcomes, and Clinical Considerations减重手术后妊娠：肝胆影响、母体结局与临床考量DOI: 10.7759/cureus.98939 Curēus IF: 01.300Volume 17, Issue 12No.196Common Risk Factors Associated With Chronic Kidney Disease in Sudan: A Pilot Study苏丹慢性肾脏病常见相关危险因素：一项初步研究DOI: 10.7759/cureus.98780 Curēus IF: 01.300Volume 17, Issue 12No.197Early-Onset Type 2 Diabetes: A Comprehensive Review From Adolescence to Adulthood早发性2型糖尿病：从青少年到成年的全面综述DOI: 10.7759/cureus.98896 Curēus IF: 01.300Volume 17, Issue 12No.198Non-dysraphic Thoracic Spinal Lipoma in an Obese Adult Woman: A Case Report一例肥胖成年女性的非脊柱闭合不全性胸椎脂肪瘤病例报告DOI: 10.7759/cureus.98832 Avicenna J Med BiotechnolVolume 17, Issue 3No.199The Quality and Quantity of Nanoparticles Extracted from Human Adipose Tissue Derived-Mesenchymal Stem Cells从人脂肪组织来源间充质干细胞提取的纳米颗粒质量与数量研究DOI: 10.18502/ajmb.v17i3.19277 Food science & nutrition IF: 03.800Volume 14, Issue 1No.200Fermented Rice Bran: A Promising Therapeutic Agent Against High-Fat Diet-Induced Metabolic Disorders发酵米糠：一种对抗高脂饮食诱导代谢紊乱的有前景的治疗剂DOI: 10.1002/fsn3.71439 Food science & nutrition IF: 03.800Volume 14, Issue 1No.201Effects of Non-Soy Legumes on Body Weight and Body Composition: A Systematic Review and Meta-Analysis of Randomized Controlled Trials非大豆类豆科植物对体重及身体成分的影响：一项随机对照试验的系统综述与荟萃分析DOI: 10.1002/fsn3.71365 J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.202Prevalence of Nonalcoholic Fatty Liver Disease in Obese Patients and its Association with Insulin Resistance Markers肥胖患者中非酒精性脂肪肝病的患病率及其与胰岛素抵抗标志物的关联DOI: 10.4103/jpbs.jpbs_1456_25 J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.203Assessing Knowledge, Attitude, Practices (KAP), Lifestyle Diseases, and Psychological Well-Being among Commercial Vehicle Drivers in Central India印度中部商用车司机的知识、态度、行为、生活方式疾病及心理福祉评估DOI: 10.4103/jpbs.jpbs_1275_25 Frontiers in nutrition IF: 05.100Volume 12, Issue No.204South Asia-specific adaptation of Mediterranean diet principles: a mixed-methods review for practical and sustainable dietary habits南亚特定地中海饮食原则适配：一项关于实用与可持续饮食习惯的混合方法综述DOI: 10.3389/fnut.2025.1719686 Korean J Community NutrVolume 28, Issue 1No.205Nutritional status and dietary behavior of North Korean adolescent refugees based on Nutrition Quotient for Korean adolescents: a preliminary study基于韩国青少年营养商数的朝鲜青少年难民营养状况与饮食行为初步研究DOI: 10.5720/kjcn.2023.28.1.1 DEN open IF: 01.500Volume 6, Issue 1No.206Efficacy and Safety of a Revised Gastric Peroral Endoscopic Myo-Neurotomy Procedure for Bariatric Endoscopy in a Porcine Model改良胃经口内镜下肌神经切断术用于减重内镜治疗在猪模型中的有效性与安全性研究DOI: 10.1002/deo2.70230 BioMed research international IF: 02.300Volume 2026, Issue No.207Hypertension and Its Determinants Among White-Collar Workers: A Cross-Sectional Study Focusing on Lifestyle Risk Factors and Health Literacy白领工作者的高血压及其相关因素：一项聚焦生活方式风险因素与健康素养的横断面研究DOI: 10.1155/bmri/3545756 Npj biological timing and sleepVolume 3, Issue 1No.208Dual roles of circadian clock proteins in development and adult homeostasis昼夜节律蛋白在发育与成年稳态中的双重作用DOI: 10.1038/s44323-025-00061-1 Case reports in surgery IF: 00.500Volume 2026, Issue No.209Preoperative Glucagon-Like Peptide-1 Receptor Agonist Treatment to Allow Safe Laparoscopic Left Pancreatectomy in Extreme Obesity: The First Report术前胰高血糖素样肽-1受体激动剂治疗以允许在极端肥胖患者中安全实施腹腔镜左半胰腺切除术：病例报告DOI: 10.1155/cris/9201182 RSC medicinal chemistry IF: 03.600Ahead of Print.No.210Mitochondria-targeting symmetric diiminoguanidines: potent and selective anticancer agents against pancreatic tumors靶向线粒体的对称二亚氨基胍：强效且选择性的抗胰腺肿瘤药物DOI: 10.1039/d5md00808e Case reports in endocrinology IF: 00.900Volume 2026, Issue No.211Adrenal Crisis Induced by Zoledronic Acid in Two Patients With Hypopituitarism: A Case Report and Literature Review唑来膦酸诱发两名垂体功能减退患者肾上腺危象：病例报告与文献回顾DOI: 10.1155/crie/8854575 Pak J Med Sci IF: 01.700Volume 41, Issue 13PINS-NNO SupplNo.212Determinants of poor prognosis after surgery for glioblastoma: A retrospective analysis of predictors of morbidity and mortality in a low-middle income country胶质母细胞瘤术后预后不良的决定因素：基于低收入国家一项回顾性分析的发病率和死亡率预测指标DOI: 10.12669/pjms.41.13(PINS-NNOS).13364 F1000ResearchVolume 14, Issue No.213Global, regional and national estimates of coexisting forms of malnutrition among the neonates, infants and young children - A secondary data analysis of Demographic & Health Surveys (DHS) from 2006 to 2024新生儿、婴幼儿及低龄儿童中共患型营养不良的全球、区域及国家评估——基于2006年至2024年人口与健康调查（DHS）的二次数据分析DOI: 10.12688/f1000research.172154.1 Korean J Community NutrVolume 28, Issue 3No.214Mercury exposure is associated with obesity: a systematic review and meta-analysis汞暴露与肥胖相关：一项系统综述和Meta分析DOI: 10.5720/kjcn.2023.28.3.192 Nutrition and metabolic insights IF: 02.200Volume 19, Issue No.215Circulating Branched-Chain Amino Acids are Associated with Higher Odds of Obesity: Findings from the FiLWHEL Study循环支链氨基酸与较高的肥胖风险相关：FiLWHEL研究的结果DOI: 10.1177/11786388251395146 Nutrition and metabolic insights IF: 02.200Volume 19, Issue No.216Targeting CD44-Hyaluronic Acid Signalling in Obesity Treatment: Insights from Small Molecules and Nanobioconjugates靶向CD44-透明质酸信号通路治疗肥胖：基于小分子与纳米生物偶联物的见解DOI: 10.1177/11786388251408961 Hepatology communications IF: 04.600Volume 10, Issue 2No.217Name MASLD/MASH - and act on it命名MASLD/MASH并采取行动DOI: 10.1097/HC9.0000000000000897 Cancer medicine IF: 03.100Volume 15, Issue 1No.218Risk of Type II Diabetes Mellitus Among B-Cell Non-Hodgkin's Lymphoma SurvivorsB细胞非霍奇金淋巴瘤幸存者罹患2型糖尿病的风险DOI: 10.1002/cam4.71367 Endocrinology IF: 03.300Ahead of Print.No.219Targeting mineralocorticoid receptors to treat metabolic diseases via the adipocyte靶向盐皮质激素受体通过脂肪细胞治疗代谢性疾病DOI: 10.1210/endocr/bqag004 International wound journal IF: 02.500Volume 23internationalwoundjournal, Issue 1, Page e70808-e70813No.220A Novel Murine Model for Studying Impaired Wound Healing in Diabetes用于研究糖尿病受损伤口愈合的新型小鼠模型DOI: 10.1111/iwj.70826 Journal of cosmetic dermatology IF: 02.500Volume 25, Issue 1No.221Rising Public Interest in Weight Loss Medications and Growing Awareness of Their Aesthetic Sequelae: An Infodemiologic Google Trends Analysis and Clinical Diagnostic Patterning减肥药公众关注度上升及其美容后遗症认知增强：一项基于谷歌趋势的信息流行病学分析与临床诊断模式研究DOI: 10.1111/jocd.70670 MITAT : IF: 02.000Ahead of Print.No.222vNOTES versus laparoscopic chromopertubation for tubal factor and unexplained infertility: a comparative studyvNOTES与腹腔镜通染术治疗输卵管因素和不明原因不孕症的比较研究DOI: 10.1080/13645706.2026.2613118 The journal of sexual medicine IF: 03.300Volume 23, Issue 2No.223Health disparities among LGBTQ+ adults aged 33-35 in northern Finland: findings from the NFBC1986 cohort芬兰北部33-35岁LGBTQ+成人的健康差异：来自NFBC1986队列的研究发现DOI: 10.1093/jsxmed/qdaf366 Prim Health Care Res Dev IF: 01.700Volume 27, Issue No.224Developing a Weight Management and Metabolic Health Program to support patient-centred, effective, and efficient treatment for veterans with overweight or obesity: protocol for a quality improvement programme开发体重管理与代谢健康项目以支持超重或肥胖退伍军人的以患者为中心、有效且高效的治疗：一项质量改进项目方案DOI: 10.1017/S1463423625100650 Am J Case Rep IF: 01.000Volume 27, Issue No.225Long-Term Outcome of Isolated Duodenal Transit Bipartition as Initial Metabolic Surgery: A 19-Year Follow-Up Case Report孤立十二指肠转位分流术作为初始代谢手术的长期结局：一项19年随访病例报告DOI: 10.12659/AJCR.950650 J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.226GH Response to Glucagon in Transition: Role of BMI and Etiology in Childhood-Onset GH Deficiency胰高血糖素刺激试验中GH反应在过渡期的评估：儿童期发病GH缺乏症中BMI与病因的作用DOI: 10.1210/clinem/dgaf674 Clinical endoscopy IF: 02.300Ahead of Print.No.227Impact of body mass index on the outcomes of endoscopic retrograde cholangiopancreatography: a systematic review and network meta-analysis体重指数对内镜下逆行胰胆管造影术预后的影响：一项系统评价与网络荟萃分析DOI: 10.5946/ce.2025.255 Obesity reviews IF: 07.400Ahead of Print.No.228Body Mass Index as a Prognostic Factor in Traumatic Brain Injury: Insights from a Real-World Cohort身体质量指数作为创伤性脑损伤的预后因素：来自真实世界队列的见解DOI: 10.1111/obr.70069 Case reports in ophthalmology IF: 00.600Volume 17, Issue 1No.229Successful Cataract Surgery in a Patient with a Port Delivery System Implant for Diabetic Macular Edema糖尿病黄斑水肿患者成功进行带眼内注射港植入物的白内障手术DOI: 10.1159/000548644 Int J Ophthalmol IF: 01.800Volume 19, Issue 1No.230Therapeutic approaches to diabetic macular edema assessed using optical coherence tomography and optical coherence tomography angiography使用光学相干断层扫描与光学相干断层扫描血管成像评估糖尿病黄斑水肿的治疗方法DOI: 10.18240/ijo.2026.01.20 J Curr Glaucoma PractVolume 19, Issue 4No.231Neovascularization of the Iris/Angle in Primary Angle Closure Glaucoma: A Distinct Entity!原发性闭角型青光眼中的虹膜/房角新生血管：一个独立的疾病实体！DOI: 10.5005/jp-journals-10078-1499 Taiwan journal of ophthalmology IF: 01.200Volume 15, Issue 4No.232Comment on optical coherence tomography and contrast sensitivity in early diabetic retinopathy评光学相干断层扫描与对比敏感度在早期糖尿病视网膜病变中的应用DOI: 10.4103/tjo.TJO-D-24-00127 Taiwan journal of ophthalmology IF: 01.200Volume 15, Issue 4No.233Effectiveness of aflibercept, ranibizumab, and Ozurdex for treating diabetic macular edema showing a suboptimal response: A comparative observational study阿柏西普、雷珠单抗与Ozurdex治疗贝伐珠单抗反应不佳的糖尿病黄斑水肿的疗效比较：一项观察性研究DOI: 10.4103/tjo.TJO-D-24-00122 Taiwan journal of ophthalmology IF: 01.200Volume 15, Issue 4No.234Clinical profile and associated risk factors of diabetic retinopathy at a tertiary eye center in Brunei Darussalam文莱达鲁萨兰国某三级眼科中心糖尿病视网膜病变的临床特征及相关危险因素DOI: 10.4103/tjo.TJO-D-24-00167 Taiwan journal of ophthalmology IF: 01.200Volume 15, Issue 4No.235Author's response to letter of editor for "Optical coherence tomography and contrast sensitivity in early diabetic retinopathy"作者对《糖尿病早期视网膜病变的光学相干断层扫描和对比敏感度》一文编辑来信的回复DOI: 10.4103/tjo.TJO-D-24-00128 PeerJ IF: 02.400Volume 14, Issue No.236An improved tortuosity measurement method combining curvature-based, breadth-first search and Euclidean distance for retinal image analysis结合基于曲率、广度优先搜索和欧氏距离的改进视网膜图像血管迂曲度测量方法DOI: 10.7717/peerj.20561 Digital health IF: 03.300Volume 12, Issue No.237Diabetic retinopathy detection and grading system using deep learning approach基于深度学习方法的糖尿病视网膜病变检测与分级系统DOI: 10.1177/20552076251410982 Quant Imaging Med Surg IF: 02.300Volume 16, Issue 1No.238Automated method for quantitative analysis of iris fluorescein angiography based on machine learning基于机器学习的虹膜荧光血管造影定量分析自动方法DOI: 10.21037/qims-2025-480 Malaysian family physicianVolume 20, Issue No.239Prevalence of postpartum glucose intolerance and its association with physical activity levels among women with prior gestational diabetes mellitus attending public primary care clinics in Penang: A cross-sectional study槟城妊娠期糖尿病史女性产后糖耐量异常患病率及其与体力活动水平的相关性：一项横断面研究DOI: 10.51866/oa.880 RC IF: 01.300Volume 26, Issue 12No.240Contemporary Percutaneous Coronary Intervention in Diabetic Patients当代糖尿病患者经皮冠状动脉介入治疗DOI: 10.31083/RCM44861 Circulation reports IF: 01.100Volume 8, Issue 1No.241Transient High-Glucose Exposure and Erk Signaling瞬时高糖暴露与Erk信号通路DOI: 10.1253/circrep.CR-25-0206 Curēus IF: 01.300Volume 17, Issue 12No.242Cardiac Arrest Secondary to Hypercapnia in an Obese Patient: A Case of Unresponsiveness With Preserved Awareness一例肥胖患者高碳酸血症继发心脏骤停：无反应状态伴意识保留的病例DOI: 10.7759/cureus.98800 World J Exp MedVolume 15, Issue 3No.243Triple probiotic combination effect on metabolic, oxidative stress, and inflammatory parameters in diabetic population: Systematic review and meta-analysis三重益生菌组合对糖尿病人群代谢、氧化应激及炎症参数的影响：系统综述与荟萃分析DOI: 10.5493/wjem.v15.i3.108467 Curēus IF: 01.300Volume 17, Issue 12No.244Prevalence and Predictors of Metabolic Syndrome in Women with Polycystic Ovarian Syndrome: A Cross-Sectional Study多囊卵巢综合征女性代谢综合征患病率及预测因素：一项横断面研究DOI: 10.7759/cureus.98869 JGH open : IF: 01.500Volume 10, Issue 1No.245Dietary Characteristics Associated With High Defecation Frequency and Constipation in Japanese Adults: A Cross-Sectional Study日本成年人中与高排便频率及便秘相关的饮食特征：一项横断面研究DOI: 10.1002/jgh3.70334 The Neurohospitalist IF: 00.900Ahead of Print.No.246Is Insulin Resistance Associated With Clinical Outcomes after Endovascular Treatment for Acute Stroke?胰岛素抵抗与急性卒中血管内治疗后临床结局相关DOI: 10.1177/19418744261416216 JCRPE IF: 01.500Ahead of Print.No.247The Potential Role of LRG1 in Hepatosteatosis and Insulin Resistance in Obese ChildrenLRG1在肥胖儿童肝脂肪变性与胰岛素抵抗中的潜在作用DOI: 10.4274/jcrpe.galenos.2026.2025-11-5 RC IF: 01.300Volume 26, Issue 12No.248Metabolic Remodeling and Mitochondrial Stress in Atrial Fibrillation: Mechanisms and Translational Targets心房颤动中的代谢重构与线粒体应激：机制与转化靶点DOI: 10.31083/RCM44688 Malaysian family physicianVolume 20, Issue No.249Vitamin B12 deficiency in metformin-treated community-dwelling older adults with diabetes: A cross-sectional multicentre study in Perak吡格列酮治疗的社区居住老年糖尿病患者维生素B12缺乏：马来西亚霹雳州的一项横断面多中心研究DOI: 10.51866/oa.718 HRB open researchVolume 8, Issue No.250Navigating Complexities In Randomized Trials: Insights From The EMERGE Trial Amidst Pandemic And Cybersecurity Threat在疫情与网络安全威胁中驾驭随机试验的复杂局面：来自EMERGE试验的启示DOI: 10.12688/hrbopenres.14233.1 J Gastrointest Oncol IF: 02.000Volume 16, Issue 6No.251Metformin reshapes the tumor microenvironment and enhances prognosis in invasive pancreatic ductal adenocarcinoma with diabetes mellitus二甲双胍重塑肿瘤微环境并改善伴糖尿病侵袭性胰腺导管腺癌的预后DOI: 10.21037/jgo-2025-457 RC IF: 01.300Volume 26, Issue 12No.252Left Atrial Reservoir Strain in Cardiovascular and Systemic Disease: Advances and Clinical Applications From Physiology to Practice左心房储器应变在心血管及系统性疾病中的应用：从生理学到临床实践的进展DOI: 10.31083/RCM46198 Curēus IF: 01.300Volume 17, Issue 12No.253Assessment of Prevalence and Risk Factors of Diabetes Distress Among Patients With Type 2 Diabetes Mellitus in an Urban Area of Chengalpattu District, India: A Cross-Sectional Study印度钦格尔普图地区城市2型糖尿病患者糖尿病困扰患病率及风险因素评估：一项横断面研究DOI: 10.7759/cureus.98974 J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.254Comparative Effect of SGLT2 Inhibitors and GLP-1 Agonists on Glycemic Control in Type 2 Diabetes MellitusSGLT2抑制剂与GLP-1激动剂对2型糖尿病患者血糖控制的比较效果DOI: 10.4103/jpbs.jpbs_1334_25 OTO open : IF: 01.500Volume 10, Issue 1No.255Thyroid Cancer Risk in Patients With Type 2 Diabetes Taking Glucagon-Like Peptide 1 Receptor Agonists使用胰高血糖素样肽-1受体激动剂的2型糖尿病患者甲状腺癌风险DOI: 10.1002/oto2.70188 Curēus IF: 01.300Volume 17, Issue 12No.256From Years of Pain to a Name: Fibromyalgia Uncovered从漫长疼痛到病名揭秘：纤维肌痛的诊断之旅DOI: 10.7759/cureus.98981 Health science reports IF: 02.100Volume 9, Issue 1No.257Weight-Reduction and Safety Profile of Once-Weekly Non-Comparable Biotherapeutic Subcutaneous Semaglutide Among People With Obesity: A Real-World Retrospective Study非可比生物治疗性皮下注射司美格鲁肽在肥胖人群中的减重效果与安全性特征：一项真实世界回顾性研究DOI: 10.1002/hsr2.71745 Curēus IF: 01.300Volume 17, Issue 12No.258Efficacy and Safety of Tirzepatide and Semaglutide for Obesity Management: A Real-World Comparison替尔泊肽与司美格鲁肽治疗肥胖的有效性和安全性：一项真实世界比较DOI: 10.7759/cureus.98858 Curēus IF: 01.300Volume 17, Issue 12No.259Blurring Fact and Fiction: A Complex Case of Recurrent Emergency Presentations, Polypharmacy, and Psychiatric Conflict事实与虚构的界限模糊：一例反复急诊、多重用药及精神科冲突的复杂病例DOI: 10.7759/cureus.98979 Alzheimer's & dementia IF: 06.800Volume 12, Issue 1No.260Baseline characteristics from evoke and evoke+: Two phase 3 randomized placebo-controlled trials of semaglutide in participants with early-stage symptomatic Alzheimer's diseaseevoke 与 evoke+ 试验的基线特征：两项在早期症状性阿尔茨海默病参与者中评估司美格鲁肽的3期随机安慰剂对照研究DOI: 10.1002/trc2.70200 194 Diabetes Mellitus(DM) 糖尿病 100 Obesity 肥胖症 67 Insulin 胰岛素 30 Type 2 diabetes mellitus(T2DM) 2型糖尿病 19 Diabetic Retinopathy 糖尿病视网膜病 16 Metabolic Syndrome 代谢综合征 13 Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA) 胰高血糖素样肽-1受体激动剂 9 Metformin 二甲双胍 7 Semaglutide 司美格鲁肽 5 Diabetic acidosis 糖尿病性酸中毒 5 Diabetic Kidney Disease(DKD) 糖尿病肾脏病 4 Diabetic Foot 糖尿病足 4 Empagliflozin 恩格列净 4 Gestational Diabetes Mellitus(GDM) 妊娠糖尿病 4 Hypoglycemic Agents 降糖药 3 Dipeptidyl-Peptidase IV Inhibitors(DPP-4i) 二肽基肽酶-4抑制剂 3 Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i) 钠-葡萄糖协同转运蛋白2抑制剂 3 Diabetic Cardiomyopathies 糖尿病心肌病 3 gamma-Aminobutyric Acid(GABA) γ-氨基丁酸 3 Liraglutide 利拉鲁肽 2 Pregabalin 普瑞巴林 2 Canagliflozin 卡格列净 2 Tirzepatide 替尔泊肽 2 Vildagliptin 维格列汀 2 Sitagliptin 西他列汀 2 Linagliptin 利格列汀 1 Alogliptin 阿格列汀 1 Dulaglutide 度拉糖肽 1 Exenatide 艾塞那肽 1 Saxagliptin 沙格列汀 1 Teneligliptin 替格列汀 1 Bexagliflozin 贝沙格列净 1 Ertugliflozin 艾托格列净 1 Sotagliflozin 索格列净 1 Diabetes Complications 糖尿病并发症 1 Dapagliflozin 达格列净 1 Diabetic Peripheral Neuropathy(PDN) 糖尿病周围神经病变编辑：韩玉莲审校：韩玉莲

100 项与苯甲酸阿格列汀相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D06553	苯甲酸阿格列汀	A10BH04	DB06203

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
2型糖尿病	日本	Takeda Pharmaceutical Co., Ltd.	2010-04-06
2型糖尿病	日本	Teijin Pharma Ltd.	2010-04-06

未上市

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
急性冠状动脉综合征	临床3期	美国	Takeda Pharmaceutical Co., Ltd.	2009-09-01
急性冠状动脉综合征	临床3期	日本	Takeda Pharmaceutical Co., Ltd.	2009-09-01
急性冠状动脉综合征	临床3期	阿根廷	Takeda Pharmaceutical Co., Ltd.	2009-09-01
急性冠状动脉综合征	临床3期	澳大利亚	Takeda Pharmaceutical Co., Ltd.	2009-09-01
急性冠状动脉综合征	临床3期	奥地利	Takeda Pharmaceutical Co., Ltd.	2009-09-01
急性冠状动脉综合征	临床3期	比利时	Takeda Pharmaceutical Co., Ltd.	2009-09-01
急性冠状动脉综合征	临床3期	巴西	Takeda Pharmaceutical Co., Ltd.	2009-09-01
急性冠状动脉综合征	临床3期	保加利亚	Takeda Pharmaceutical Co., Ltd.	2009-09-01
急性冠状动脉综合征	临床3期	加拿大	Takeda Pharmaceutical Co., Ltd.	2009-09-01
急性冠状动脉综合征	临床3期	智利	Takeda Pharmaceutical Co., Ltd.	2009-09-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02856113 (2015-000208-25, Pubmed \| Diabetes Ther)	临床3期	2型糖尿病	152	Alogliptin 25 mg QD	構蓋廠醖艱襯淵膚簾構(構窪顧淵構淵繭積餘選) = 鹹艱繭構齋淵壓襯艱鑰憲憲齋衊構蓋憲選鬱構 (齋衊襯醖壓繭構遞齋築, -0.63 ~ 0.83)	不佳	2025-03-04
1340-P (ADA2024)	N/A	糖尿病	-	SGLT2i	糧鑰鬱蓋鑰網齋廠鏇構(襯觸淵壓夢壓糧鹽衊夢) = 艱醖製網艱夢願廠積淵壓構鏇淵獵顧窪鹽網鹹 (築艱網網鹽築糧壓鏇廠, 16.6 ~ 19.7)	积极	2024-06-14
				DPP4i	糧鑰鬱蓋鑰網齋廠鏇構(襯觸淵壓夢壓糧鹽衊夢) = 願願鹽夢夢壓膚繭製簾壓構鏇淵獵顧窪鹽網鹹 (築艱網網鹽築糧壓鏇廠, 19.1 ~ 21.4)
NCT05782192 (Pubmed)	临床3期	2型糖尿病	-	Fotagliptin	淵糧窪鹽鬱餘願衊構顧(觸廠顧糧淵鬱壓願網齋) = 築衊艱襯遞鏇構選窪範鑰衊憲膚鑰襯醖鹹繭鏇 (鹹糧衊積蓋網艱簾觸憲 ) 更多	积极	2023-10-09
				Alogliptin	淵糧窪鹽鬱餘願衊構顧(觸廠顧糧淵鬱壓願網齋) = 衊構齋選鹹觸鏇觸淵積鑰衊憲膚鑰襯醖鹹繭鏇 (鹹糧衊積蓋網艱簾觸憲 ) 更多
NCT02856113 (2015-000208-25, CTgov)	临床3期	2型糖尿病	152	Placebo (Placebo)	網製糧網艱簾選醖蓋醖(遞壓繭壓顧簾窪積觸觸) = 衊願範簾淵齋夢蓋觸鹽築遞顧鏇襯築遞製積網 (簾餘襯憲壓艱築鏇齋範, 0.2809) 更多	-	2022-10-19
				Alogliptin Benzoate (Alogliptin 25 mg)	網製糧網艱簾選醖蓋醖(遞壓繭壓顧簾窪積觸觸) = 襯積淵壓鏇獵願壓網醖築遞顧鏇襯築遞製積網 (簾餘襯憲壓艱築鏇齋範, 0.2879) 更多
NCT03794336 (ACADEMIC, Pubmed \| Diabetes Obes Metab) 人工标引	临床4期	2型糖尿病 \| 冠状动脉疾病	1,088	aspirin+alogliptin	蓋鏇積構憲鹹鏇鏇壓醖(鏇顧憲鹹淵遞鏇艱廠鏇) = 製齋憲鏇憲憲繭夢壓遞鏇繭簾顧繭艱壓選選製 (膚餘廠齋構鹹艱願艱網, 0.4) 更多	积极	2022-02-03
				aspirin+acarbose	蓋鏇積構憲鹹鏇鏇壓醖(鏇顧憲鹹淵遞鏇艱廠鏇) = 憲糧繭觸鏇鏇鹽膚廠鬱鏇繭簾顧繭艱壓選選製 (膚餘廠齋構鹹艱願艱網, 0.5) 更多
NCT03794336 (EASD2021)	临床4期	2型糖尿病 \| 心血管疾病 \| 冠状动脉疾病	-	Alogliptin 25 mg q.d.	製願簾觸願遞夢範積網(鬱憲齋範顧鹹齋獵願鹹) = Significantly lesser GI adverse events were observed with alogliptin than acarbose (8.9% vs 33.6%, P <0.0001) 觸顧齋艱夢廠製醖構艱 (鏇積觸願鏇憲淵鹽願繭 ) 更多	积极	2021-09-29
				Acarbose 100 mg t.i.d.
NCT03231709 (TRINITY, Pubmed \| Curr Med Res Opin)	临床4期	2型糖尿病	-	Trelagliptin	憲簾鏇築艱衊廠簾鏇壓(築構鹽範繭窪鑰衊繭艱) = 願糧廠鬱夢廠繭壓膚繭選夢醖鬱憲簾獵網遞膚 (襯鏇製顧窪鹽獵餘襯構 )	-	2019-12-02
				Alogliptin	憲簾鏇築艱衊廠簾鏇壓(築構鹽範繭窪鑰衊繭艱) = 衊顧憲齋構構壓醖積淵選夢醖鬱憲簾獵網遞膚 (襯鏇製顧窪鹽獵餘襯構 )
NCT03501277 (CTgov)	临床1期	-	72	alogliptin+pioglitazone+SYR-322-4833 BL (Regimen A)	鹹窪餘蓋範鹹襯製選壓(襯餘鹹獵願積鹽淵構壓) = 鏇壓淵選獵廠齋壓顧範繭鬱鬱獵範鑰選觸觸糧 (蓋獵襯窪製鬱鹽襯淵願, 42.87) 更多	-	2019-08-08
				Alogliptin+pioglitazone (Regimen B)	鹹窪餘蓋範鹹襯製選壓(襯餘鹹獵願積鹽淵構壓) = 鹹鹽醖獵淵製網獵鹽願繭鬱鬱獵範鑰選觸觸糧 (蓋獵襯窪製鬱鹽襯淵願, 44.71) 更多
NCT03231709 (TRINITY, CTgov)	临床4期	2型糖尿病	60	Trelagliptin+Alogliptin (Trelagliptin 100 mg + Alogliptin 25 mg)	鹽憲齋醖顧遞廠壓膚鏇 = 製鹹繭獵鏇蓋鹹願遞艱鬱鑰鏇觸繭鬱構夢夢夢 (願餘憲鹽鬱構糧網網選, 範艱蓋選廠範鬱鹽願憲 ~ 膚鏇網顧網艱鏇顧範築) 更多	-	2019-05-10
				Trelagliptin+Alogliptin (Alogliptin 25 mg + Trelagliptin 100 mg)	鹽憲齋醖顧遞廠壓膚鏇 = 製憲簾顧獵範醖衊廠淵鬱鑰鏇觸繭鬱構夢夢夢 (願餘憲鹽鬱構糧網網選, 構夢鏇獵網鹹鬱蓋簾艱 ~ 築襯淵鹽廠願簾醖鏇鏇) 更多
NCT02771093 (TRACK, CTgov)	临床4期	2型糖尿病	27	Trelagliptin (Trelagliptin 100 mg)	構積淵壓醖築願觸衊膚(觸繭壓艱繭夢製鹽製繭) = 壓構選選襯壓窪衊範願膚糧鏇衊夢繭糧願觸簾 (鬱淵膚範壓簾鑰蓋齋蓋, 鹹繭鏇襯遞鹹鹽鑰憲鏇 ~ 憲淵範選膚鬱襯觸觸獵) 更多	-	2018-12-10
				Alogliptin (Alogliptin 25 mg)	構積淵壓醖築願觸衊膚(觸繭壓艱繭夢製鹽製繭) = 蓋衊糧餘鬱鑰範壓簾艱膚糧鏇衊夢繭糧願觸簾 (鬱淵膚範壓簾鑰蓋齋蓋, 範衊憲鏇繭築製鏇齋觸 ~ 獵衊衊壓顧構製餘廠憲) 更多