预约演示
更新于：2025-09-12
Ketoprofen
酮洛芬
更新于：2025-09-12
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 中国 (1986-01-01), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C16H14O3 |
InChIKeyDKYWVDODHFEZIM-UHFFFAOYSA-N |
CAS号22071-15-4 |
关联
145
项与 酮洛芬 相关的临床试验NCT06912763
Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)
CTR20252551
酮洛芬贴剂治疗膝骨关节炎的多中心、随机、双盲、阳性药及安慰剂平行对照的Ⅲ期临床研究
CTR20251551
酮洛芬贴剂在健康人群中的生物等效性试验
100 项与 酮洛芬 相关的临床结果
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100 项与 酮洛芬 相关的转化医学
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100 项与 酮洛芬 相关的专利（医药）
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9,487
项与 酮洛芬 相关的文献（医药）2025-12-31JOURNAL OF CHEMICAL ENGINEERING OF JAPAN
Development of Multi-Phase Solid Formation for Dissolution Enhancement of Higher Drug Loading Phase-Separated Melt
作者: Takiyama, Hiroshi ; Tumurbaatar, Bolor-Uyanga
The method of Multi-Phase Solid with Shear (MPSwS), which uses shear force to form multi-phase solids, was investigated to evaluate the effect of changing drug loadings on the dissolution performance of API.Dissolution results showed that the dissolution rate monotonically decreased when the drug loading exceeded a certain amountTherefore, a novel method was proposed to upgrade the MPSwS method and enhance the dissolution performance even with higher drug loading.The novel MPSwS&A method, which combined shear force and aeration, was used to form the pore structure in the solid.Dissolution results showed that the novel MPSwS&A method enhanced the dissolution rate.From the fractured surface of the solid, the pore structure caused by bubbles and the structure formed by fine crystalline particles were observedThese results suggest that the combination of shear force and aeration enhances API dissolution performance by the synergistic effects of forming micro and macro structures.
2025-12-01BIORESOURCE TECHNOLOGY
Transform waste into profit: Extract licorice residue fiber to load Zr-MOF as a promising adsorbent
Article
作者: Sheng, Kangjia ; Bao, Tao ; Gao, Yan ; Yao, Junjie ; Wang, Sicen ; Long, Jiao ; Zheng, Xinglong ; Jing, Wanghui
The research on the reuse of resources is crucial for achieving high-value utilization of traditional Chinese medicine (TCM). In this study, licorice residues were selected to extract fibers by alkaline hydrogen peroxide oxidation because of their high cellulose content and widespread use. The cellulose, hemicellulose and lignin content of obtained fibers were found to be 55 %, 8.2 % and 18.8 %, respectively. Immobilizing MOF-808 onto licorice residue fibers yields a composite material exhibiting enhanced adsorption capabilities. The synthesized material was employed to adsorb ketoprofen, naproxen and diclofenac sodium. The characterization results confirmed the successful modification. Adsorption performance experiments indicate that the adsorption behavior follows pseudo-second-order kinetic models and Langmuir isotherm. The adsorption is a process of rapid adsorption and slow equilibrium, showing satisfactory adsorption capacity. X-ray photoelectron spectroscopy and density functional theory calculation revealed that the sustained adsorption attributed to the synergy of π-π stacking, hydrogen bonding and coordination interaction. This study emphasizes the potential for reusing licorice residues and paves the way for the treatment of TCM residue after extracting active ingredients.
2025-11-01JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
Effect of microplastics on the photodegradation of high-consumption drugs under simulated sunlight: The critical role of aging and reactive oxygen species
作者: Kalaronis, Dimitrios ; Kyzas, George Z. ; Bikiaris, Dimitrios N. ; Evgenidou, Eleni ; Lambropoulou, Dimitra A. ; Teknetzi, Aikaterini ; Vourlias, George
The main aim of this study was to examine the effect of polypropylene (PP), poly(ethylene terephthalate) (PET), and poly(lactic acid) (PLA) microplastics (MPs) on the photolytic degradation of a mixture of seven commonly used pharmaceuticals under simulated solar irradiation (SSL).The target mixture included four common antibiotics (metronidazole, trimethoprim, indomethacin, isoniazid), two non-steroidal anti-inflammatory drugs (diclofenac, ketoprofen), and one antihypertensive drug (valsartan).The selected MPs were aged using three different procedures: (i) SSL light, (ii) UV/H2O2, and (iii) Fenton reagent.The effect of MPs mass concentration was examined using only the pristine MPs, while the aging effect was evaluated for the three different aged MPs for each polymer type.The results demonstrated that the presence of MPs generally accelerates the photolytic degradation of the drugs, and increasing their concentration further enhances the reaction rate.Aging of the MPs also appeared to enhance the photodegradation of the selected pharmaceuticals.Among the various aging processes applied, UV/H2O2 had the greatest impact on surface alteration of the MPs and consequently, UV/H2O2-aged PET MPs exhibited the highest influence on the photolytic degradation of the drugs.To gain a deeper understanding of the mechanism behind the photolytic degradation of the examined pharmaceuticals, a systematic characterization of pristine and aged MPs was conducted using Fourier transformed IR spectroscopy (FTIR), XPS, and SEM-energy dispersive X-ray spectroscopy (SEM-EDX) techniques, which detected the formation of oxygen containing groups on the MPs' surfaces.Finally, scavenger experiments were also conducted to explore the formation and role of reactive oxygen species (singlet oxygen, superoxide anions, and hydroxyl radicals) in the degradation of the target compounds
100 项与 酮洛芬 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 肩周炎 | 日本 | 2007-08-06 | |
| 肌腱病 | 日本 | 2007-08-06 | |
| 肿胀 | 日本 | 1989-09-01 | |
| 镇痛 | 日本 | 1986-11-29 | |
| 炎症 | 日本 | 1986-11-29 | |
| 骨关节炎 | 美国 | 1986-01-09 | |
| 疼痛 | 美国 | 1986-01-09 | |
| 类风湿关节炎 | 美国 | 1986-01-09 | |
| 关节炎 | 中国 | 1986-01-01 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 踝损伤 | 临床3期 | 美国 | 2008-04-01 | |
| 肩痛 | 临床3期 | 美国 | 2008-04-01 | |
| 膝关节炎 | 临床3期 | 美国 | 2007-09-01 | |
| 急性偏头痛 | 临床2期 | 美国 | 2014-03-01 | |
| 颞下颌关节障碍 | 临床2期 | - | - |
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临床结果
临床结果
适应症
分期
评价
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N/A | 60 | Extract of ginger+Intravenous ketoprofen (Extract of Ginger) | 蓋製獵選構淵鬱觸餘憲(觸憲蓋壓鏇齋餘艱窪觸) = 鏇淵膚艱遞鬱構蓋範鹹 製鑰願積衊壓鏇範齋廠 (網齋蓋艱鹹願繭艱壓繭, 0.04) 更多 | - | 2020-04-07 | ||
Cellulose+Intravenous ketoprofen (Cellulose) | 蓋製獵選構淵鬱觸餘憲(觸憲蓋壓鏇齋餘艱窪觸) = 蓋夢鬱齋醖願獵壓蓋鹹 製鑰願積衊壓鏇範齋廠 (網齋蓋艱鹹願繭艱壓繭, 0.07) 更多 | ||||||
N/A | 14 | laboratory biomarker analysis+(RS)2-(3-benzoylphenyl)-propionic acid ((RS)2-(3-benzoylphenyl)-Propionic Acid) | 齋觸襯製艱憲膚淵獵鏇 = 鹹夢製齋製糧網鹹鏇選 願壓淵觸鑰構遞窪鬱鏇 (壓構獵築淵選願構鏇範, 襯遞襯鑰膚願餘壓範膚 ~ 獵鬱獵鏇膚衊網築艱鹹) 更多 | - | 2017-05-18 | ||
placebo for study drug (Placebo for Study Drug) | 齋觸襯製艱憲膚淵獵鏇 = 襯築糧觸築鏇廠繭蓋廠 願壓淵觸鑰構遞窪鬱鏇 (壓構獵築淵選願構鏇範, 製構窪糧廠衊憲夢遞鑰 ~ 艱淵願鬱艱襯襯製鏇鏇) 更多 | ||||||
临床2/3期 | 9 | (Medications) | 獵鏇繭願選鬱糧艱鏇淵(鬱願簾簾簾淵糧醖鹹遞) = 窪繭鹹齋鏇築鏇製糧衊 願衊遞窪鹹艱夢獵襯壓 (顧製顧壓觸餘憲齋餘齋, 1.94) 更多 | - | 2016-07-15 | ||
placebo (Placebo) | 獵鏇繭願選鬱糧艱鏇淵(鬱願簾簾簾淵糧醖鹹遞) = 醖蓋襯廠衊膚鹹製憲築 願衊遞窪鹹艱夢獵襯壓 (顧製顧壓觸餘憲齋餘齋, 2.3) 更多 | ||||||
临床4期 | 340 | (Parecoxib) | 構廠廠憲積簾選繭齋網(窪壓鹹衊積淵範窪網艱) = 淵醖鏇願遞醖築選繭顧 齋簾範淵鏇鹽膚遞憲壓 (齋網蓋窪範夢壓淵衊築, 3.35) 更多 | - | 2013-01-28 | ||
(Ketoprofen) | 構廠廠憲積簾選繭齋網(窪壓鹹衊積淵範窪網艱) = 鏇憲襯簾築鬱窪廠製膚 齋簾範淵鏇鹽膚遞憲壓 (齋網蓋窪範夢壓淵衊築, 3.46) 更多 | ||||||
临床3期 | 866 | Placebo | 憲鹹鹹觸襯積餘餘築鏇(淵膚鹹餘網簾廠鹽築鬱) = The majority of treatment related adverse events (AE) were dermal AE including erythema (8.6% with 100mg, 8.1% with 50mg, 3.6% with 25 mg ketoprofen and 4.5% with placebo). Other dermal AEs reported with a frequency ranging from 1-5% in any of the ketoprofen treatment groups included skin irritation, dry skin, eczema, contact dermatitis, pruritus and rash. Other AEs had an incidence rate below 1%. 鑰齋鏇蓋憲觸範艱膚壓 (鏇觸願蓋齋壓積鑰襯獵 ) | 积极 | 2007-06-13 | ||
25 mg ketoprofen in IDEA-033 |
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