预约演示
更新于：2026-01-28
Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Alafenamide Fumarate
恩曲他滨/盐酸利匹韦林/富马酸磷丙替诺福韦
更新于：2026-01-28
概要
基本信息
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2016-03-01), |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C22H19ClN6 |
InChIKeyKZVVGZKAVZUACK-BJILWQEISA-N |
CAS号700361-47-3 |
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关联
6
项与 恩曲他滨/盐酸利匹韦林/富马酸磷丙替诺福韦 相关的临床试验PACTR202209528604242
Safety and Pharmacokinetics of TAF-FTC Pre-Exposure Prophylaxis in Kenyan Cisgender women- of TDF-FTC Pre-exposure Prophylaxis in Kenyan Cisgender women.
CTR20220535
恩曲他滨利匹韦林丙酚替诺褔韦片的人体生物等效性研究
NCT03092206
Changes in Insulin Sensitivity in Healthy Volunteers Taking Tenofovir Alafenamide (TAF)-Containing Antiretroviral Medication: The TAF-IR Study
100 项与 恩曲他滨/盐酸利匹韦林/富马酸磷丙替诺福韦 相关的临床结果
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100 项与 恩曲他滨/盐酸利匹韦林/富马酸磷丙替诺福韦 相关的转化医学
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100 项与 恩曲他滨/盐酸利匹韦林/富马酸磷丙替诺福韦 相关的专利（医药）
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4
项与 恩曲他滨/盐酸利匹韦林/富马酸磷丙替诺福韦 相关的文献（医药）2024-01-01Clinical Laboratory
Rapid Detection of Entamoeba histolytica Using FilmArray Gastrointestinal Panel: Enhancing Early Treatment and Outcomes
Letter
作者: Tseng, Yu-Wei ; Chen, Si-Yu ; Er, Tze-Kiong ; Lin, Yu-Ta ; Chou, Yung-Che
BACKGROUND:
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal amebiasis and can cause severe complications. It is prevalent in tropical and subtropical regions and is a significant health concern in developing countries. Traditional diagnostic methods often delay the diagnosis, leading to prolonged patient suffering and increased risk of complications.
METHODS:
We report the case of a 59-year-old HIV-positive man on Odefsey, who presented with a week-long history of abdominal pain and diarrhea. Initial stool analysis suggested bacterial colitis, and empirical treatment with levofloxacin was initiated. However, the patient's condition worsened, resulting in hospitalization. Laboratory findings included elevated white blood cell count and high-sensitivity C-reactive protein, with low plasma sodium and potassium levels. Stool bacterial cultures were negative for common pathogens.
RESULTS:
Rapid diagnosis was achieved using the FilmArray GI Panel, which detected E. histolytica within an hour. Subsequent stool microscopy suggested the presence of E. histolytica/E. dispar cysts. Prompt antiamoebic therapy with metronidazole and paromomycin resulted in significant clinical improvement. The case was reported to the Centers for Disease Control (CDC) as a Category II notifiable disease.
CONCLUSIONS:
This case underscores the critical role of the FilmArray GI Panel in the rapid detection of E. his-tolytica, facilitating timely and effective treatment. Early diagnosis using advanced molecular diagnostics significantly improves patient outcomes and should be incorporated into routine clinical practice for managing gastrointestinal infections.
2022-12-01AIDS (London, England)
Estimated changes in price discounts for tenofovir-inclusive HIV treatments following introduction of tenofovir alafenamide
Article
作者: Sean Dickson ; Inmaculada Hernandez ; Nico Gabriel
We estimated list and net prices for tenofovir disoproxil fumarate (TDF) products Truvada, Complera, and Stribild, and their tenofovir alafenamide (TAF) versions Descovy, Odefsey, and Genvoya. Gilead offered discounts for Descovy that resulted into lower net prices compared to Truvada. This strategy encouraged patients switching from Truvada to Descovy before the availability of generic Truvada. Conversely, Gilead offered lower discounts for Odefsey and Genvoya, which resulted into higher net prices compared to Complera and Stribild.
2016-11-01Biochemical pharmacology2区 · 医学
Tenofovir alafenamide (TAF) as the successor of tenofovir disoproxil fumarate (TDF)
2区 · 医学
Review
作者: De Clercq, Erik
Tenofovir alafenamide (TAF) can be considered a new prodrug of tenofovir (TFV), as successor of tenofovir disoproxil fumarate (TDF). It is in vivo as potent against human immunodeficiency virus (HIV) at a 30-fold lower dose (10mg) than TDF (300mg). TAF has been approved in November 2015 (in the US and EU), as a single-tablet regimen (STR) containing 150mg elvitegravir (E), 150mg cobicistat (C), 200mg emtricitabine [(-)FTC] (F) and 10mg TAF, marketed as Genvoya®, on 01 March 2016 in the US as an STR containing 25mg rilpivirine (R), 200mg F and 25mg TAF, marketed as Odefsey®, and on 4 April 2016 in the US, as an STR containing 200mg F and 25mg TAF, marketed as Descovy®, for the treatment of HIV infections. STR combinations containing TAF and emtricitabine could be paired with a range of third agents, for example, darunavir and cobicistat. TAF has a much lower risk of kidney toxicity or bone density changes than TDF, and also offers long-term potential in the pre-exposure prophylaxis (PrEP) of HIV infections. TAF is specifically accumulated in lymphatic tissue, and in the liver, and hence also holds great potential for the treatment of hepatitis B virus (HBV) infections. Akin to TDF, TAF is converted intracellularly to TFV. Its active diphosphate metabolite (TFVpp) is targeted at the RNA-dependent DNA polymerase (reverse transcriptase) of either HIV or HBV.
100 项与 恩曲他滨/盐酸利匹韦林/富马酸磷丙替诺福韦 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| HIV感染 | 美国 | 2016-03-01 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 丙型肝炎 | 临床3期 | 美国 | 2016-04-01 | |
| HIV血清阳性 | 临床3期 | 美国 | 2015-01-26 | |
| HIV血清阳性 | 临床3期 | 比利时 | 2015-01-26 | |
| HIV血清阳性 | 临床3期 | 加拿大 | 2015-01-26 | |
| HIV血清阳性 | 临床3期 | 法国 | 2015-01-26 | |
| HIV血清阳性 | 临床3期 | 德国 | 2015-01-26 | |
| HIV血清阳性 | 临床3期 | 意大利 | 2015-01-26 | |
| HIV血清阳性 | 临床3期 | 荷兰 | 2015-01-26 | |
| HIV血清阳性 | 临床3期 | 西班牙 | 2015-01-26 | |
| HIV血清阳性 | 临床3期 | 瑞典 | 2015-01-26 |
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临床结果
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适应症
分期
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临床3期 | 150 | 築窪構範簾願製鬱廠蓋 = 糧醖選艱網鹽壓構築艱 範遞選獵鹹鹹觸鏇鬱壓 (顧範夢衊艱淵選壓築襯, 鬱顧齋遞積廠構築糧糧 ~ 範窪鏇壓鏇窪憲製醖製) 更多 | - | 2018-10-09 | |||
築窪構範簾願製鬱廠蓋 = 憲艱憲廠鬱選鑰製鬱夢 範遞選獵鹹鹹觸鏇鬱壓 (顧範夢衊艱淵選壓築襯, 餘齋鬱構鑰築遞壓夢廠 ~ 顧網築獵鑰網網齋醖築) 更多 | |||||||
临床3期 | 632 | FTC/RPV/TDF Placebo+FTC/RPV/TAF (FTC/RPV/TAF) | 壓鑰範壓壓艱糧製蓋簾 = 餘壓築餘鏇鑰衊蓋鏇鹽 夢簾願顧鏇襯製願夢壓 (膚鹹築夢獵選築獵糧願, 鹽鹽蓋廠構獵夢衊選襯 ~ 蓋醖網選衊製廠鏇蓋網) 更多 | - | 2017-12-08 | ||
FTC/RPV/TAF Placebo+FTC/RPV/TDF (FTC/RPV/TDF) | 壓鑰範壓壓艱糧製蓋簾 = 願憲鏇糧廠鬱壓願觸簾 夢簾願顧鏇襯製願夢壓 (膚鹹築夢獵選築獵糧願, 艱淵願獵鏇窪鬱膚膚鹽 ~ 憲襯襯醖鑰餘觸遞構憲) 更多 | ||||||
临床3期 | 881 | EFV/FTC/TDF Placebo+FTC/RPV/TAF (FTC/RPV/TAF) | 餘鹹簾夢範淵顧鬱觸鑰 = 製壓蓋餘製鹽鬱遞襯獵 醖網鑰鏇廠顧鹹鬱鏇築 (構網餘選觸鬱製鹹憲獵, 廠選窪餘餘簾繭窪衊獵 ~ 積顧獵窪選願構衊糧網) 更多 | - | 2017-10-19 | ||
餘鹹簾夢範淵顧鬱觸鑰 = 網鑰衊艱鏇鬱構鹽夢窪 醖網鑰鏇廠顧鹹鬱鏇築 (構網餘選觸鬱製鹹憲獵, 顧鬱鏇積蓋齋膚範遞廠 ~ 遞選襯獵壓齋積夢選構) 更多 | |||||||
N/A | - | 1,505 | 製壓築鬱壓鬱衊網鑰鹹(衊製製艱膚膚衊範鏇鬱) = 鹹簾衊顧遞選網獵蓋選 鹹積觸夢願遞糧構簾鹹 (醖製獵顧簾淵膚衊壓衊 ) 更多 | - | 2017-01-01 | ||
製壓築鬱壓鬱衊網鑰鹹(衊製製艱膚膚衊範鏇鬱) = 齋艱鏇簾襯憲遞積醖繭 鹹積觸夢願遞糧構簾鹹 (醖製獵顧簾淵膚衊壓衊 ) 更多 |
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