更新于：2024-12-07
Fentanyl Citrate
枸橼酸芬太尼
更新于：2024-12-07
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1968-02-19), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C28H36N2O8 |
InChIKeyIVLVTNPOHDFFCJ-UHFFFAOYSA-N |
CAS号990-73-8 |
关联
129
项与 枸橼酸芬太尼 相关的临床试验Parturient Satisfaction With Epidural Analgesia During Parturient Controlled Pump
Comparison Between Effect of Systemic Fentanyl Infusion and Fentanyl Added As an Adjuvant to Lidocaine in Bier Block for Controlling Pain in Patients Undergoing Hand Surgeries
Analgesic efficacy of wound infiltration with fentanyl or bupivacaine or bupivacaine with fentanyl in arthroscopic anterior cruciate ligament reconstructive surgery: A double blind randomized control trial - NIL
100 项与 枸橼酸芬太尼 相关的临床结果
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100 项与 枸橼酸芬太尼 相关的转化医学
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100 项与 枸橼酸芬太尼 相关的专利（医药）
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483
项与 枸橼酸芬太尼 相关的文献（医药）2024-11-06Cureus Journal of Medical Science
Effective Pain Management of Postherpetic Neuralgia Using a Combination of Analgesics and Conservative Measures
Article
作者: Iino, Shiro ; Hirono, Yasuo ; Fukumoto, Shintaro ; Kodama, Maiko ; Kitano, Yuhei ; Takano, Chihaya ; Tsubaki, Takayoshi ; Kodaka, Erina
Postherpetic neuralgia (PHN) is characterized by persistent pain following the resolution of a herpes zoster rash. PHN is often resistant to treatment and can significantly reduce the patient's quality of life. Effective symptom relief is crucial and various treatments, including pharmacotherapy, have been attempted. Given that symptoms can persist for a prolonged period, they can substantially affect the physical and mental well-being of the patients. A 73-year-old man developed herpes zoster while undergoing treatment for a head angiosarcoma. Despite the resolution of the rash, the pain persisted, leading to the diagnosis of PHN. Treatment was initiated with a range of medications, including mecobalamin, pregabalin, and a combination of tramadol and acetaminophen, along with general pain relievers standardized as WHO Step 1 medications, which include acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs). However, achieving adequate pain control is challenging and results in frequent hospitalizations. Due to the patient's depression and the concurrent use of a selective serotonin reuptake inhibitor, duloxetine hydrochloride could not be prescribed. Instead, opioid therapy with continuous fentanyl citrate infusion was initiated. Eventually, the treatment was switched to oxycodone hydrochloride, which successfully stabilized the patient's symptoms. The use of conservative measures such as hot compresses also contributes to symptom relief. Alleviating pain symptoms using a combination of pharmacotherapeutic and non-pharmacological treatments is extremely important.
2023-07-22BMC anesthesiology
Effect of nalbuphine plus ropivacaine on vaginal labor in epidural analgesia.
Article
作者: Cao, Xiao-Sheng ; Pang, Zhao ; Wen, Xue-Jin ; Ou, Lian-Chun ; Yin, Biao ; Liu, Li-Wen ; Liu, Guo-Hua ; He, Quan-Yan
BACKGROUND:
Various approaches using epidural analgesia have been employed for relieving labor pain and promoting spontaneous delivery. We aimed to evaluate the effect of nalbuphine and ropivacaine versus fentanyl and ropivacaine on the duration of delivery in parturients.
METHODS:
Clinical data of 160 full-term primiparous women who received either nalbuphine or fentanyl in combination with ropivacaine infusion for epidural labor analgesia in our hospital from December 2020 to May 2022 were retrospectively analyzed. The participants were divided into two groups based on anesthesia methods: nalbuphine group (NR group, n = 78) received 0.2 mg/mL nalbuphine combined with 0.1% ropivacaine hydrochloride for patient-controlled epidural analgesia (PCEA) and fentanyl group (FR group, n = 82) received 2 ug/mL fentanyl citrate and 0.1% ropivacaine hydrochloride for PCEA. Both groups received an epidural blockade for labor analgesia at lumbar 2-3 interspace. The duration of the first, second, and third stages of labor, the onset of analgesia, and time before delivery (T0), 15 min of analgesia (T1), 30 min of analgesia (T2), full opening of the uterine opening (T3),exerts force during childbirth(T4), heart rate (HR), blood pressure (BP), blood saturation (SpO2), visual analogue pain scale (VAS) score, Ramsay sedation score, and modified Bromage score, and 5 min were recorded at 2 h postpartum (T5). The neonatal Apgar score, neonatal behavioral neurological assessment (NBNA) score, maternal nausea, vomiting, and itchy skin were recorded.
RESULTS:
Compared with the FR group, the first stage of labor duration (p < 0.05) and total duration of labor (p < 0.05) were shortened and the onset of analgesia (p < 0.05) was increased in the NR group. NR group had lower incidence of urinary retention than FR group (p < 0.05). The maternal and neonatal investigational parameters and scores had no significant difference between the two groups.
CONCLUSIONS:
Nalbuphine combined with ropivacaine in epidural block labor has a faster onset of analgesia and has a lower incidence of urinary retention than fentanyl combined with ropivacaine, and nalbuphine shortens the duration of the first and total stages of labor. Both nalbuphine and fentanyl can reduce pain during labor, have little effect on maternal hemodynamics, and have no significant effect on neonatal Apgar or NBNA scores.
2023-05-01Applied spectroscopy
Quantitative Raman Cross-Sections and Band Assignments for Fentanyl and Fentanyl Analogs
Article
作者: Kline, Neal D. ; Wilcox, Phillip G. ; Pardoe, Ian J. ; Emmons, Erik D. ; Guicheteau, Jason A.
Raman cross sections and spectra were measured for five synthetic opioid fentanyl analogs: fentanyl citrate, sufentanil citrate, alfentanil HCl, carfentanil oxalate, and remifentanil HCl. The measurements were performed with excitation wavelengths in the visible (532 nm) and near infrared (785 nm). In addition, density functional theory (DFT) calculations were employed to generate simulated spectra of the compounds and aid in identification of the observed spectral modes. These cross-section measurements and calculations were also used to assess results from a series of measurements of fentanyls cut with other powdered materials. These measurements are valuable for assessment of field-deployable Raman chemical sensors for detection of fentanyl and fentanyl analogs, including when mixed with other materials.
100 项与 枸橼酸芬太尼 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 疼痛 | 美国 | 2009-07-16 | |
| 突出痛 | 欧盟 | 2008-04-04 | |
| 突出痛 | 冰岛 | 2008-04-04 | |
| 突出痛 | 列支敦士登 | 2008-04-04 | |
| 突出痛 | 挪威 | 2008-04-04 | |
| 癌症疼痛 | 美国 | 1998-11-04 | |
| 妊娠剧吐 | 中国 | 1981-01-01 | |
| 麻醉 | 美国 | 1968-02-19 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 头颈部肿瘤 | 临床3期 | 意大利 | 2014-09-01 | |
| 腰痛 | 临床3期 | 美国 | 2005-09-01 | |
| 神经痛 | 临床3期 | 美国 | 2005-09-01 | |
| 肿瘤 | 临床3期 | 美国 | 2004-04-01 | |
| 镰状细胞血症 | 临床2期 | 美国 | 2006-10-01 | |
| 镰状细胞血症 | 临床2期 | 加拿大 | 2006-10-01 | |
| 镰状细胞血症 | 临床2期 | 波多黎各 | 2006-10-01 | |
| 烧伤 | 临床2期 | 美国 | 2006-10-01 | |
| 烧伤 | 临床2期 | 加拿大 | 2006-10-01 | |
| 烧伤 | 临床2期 | 波多黎各 | 2006-10-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | - | 24 | (Duragesic) | 蓋鏇憲製鹽餘鑰網鏇積(糧鹹蓋願鹽鏇遞構選襯) = 繭鏇鏇壓顧繭衊糧艱醖 繭廠襯蓋顧壓廠繭積獵 (選膚願構繭鬱顧壓網醖, 憲襯簾繭醖壓簾鏇衊鏇 ~ 獵繭遞遞鏇醖構積製膚) | - | 2020-03-26 | |
(Mylan) | 蓋鏇憲製鹽餘鑰網鏇積(糧鹹蓋願鹽鏇遞構選襯) = 遞壓壓齋醖願廠願範製 繭廠襯蓋顧壓廠繭積獵 (選膚願構繭鬱顧壓網醖, 夢築鏇淵網糧醖觸築艱 ~ 遞廠夢艱鑰範窪鹹鑰襯) | ||||||
临床2期 | 33 | (Arm A (EMLA)) | 願廠構蓋鑰選觸網鏇糧(鑰範艱積齋鏇選選憲獵) = 艱餘襯範願膚繭製衊艱 夢築醖鏇憲選願夢簾選 (範網簾鹹廠壓壓淵糧襯, 醖鬱簾淵醖鹽築製鹹範 ~ 獵鹽憲繭獵願鹹憲獵憲) 更多 | - | 2019-09-06 | ||
Placebo (Arm B (Placebo)) | 願廠構蓋鑰選觸網鏇糧(鑰範艱積齋鏇選選憲獵) = 艱廠艱鬱餘選壓窪鹽憲 夢築醖鏇憲選願夢簾選 (範網簾鹹廠壓壓淵糧襯, 餘膚簾繭網選醖鹹簾膚 ~ 積膚製願顧淵夢窪鬱網) 更多 | ||||||
临床2期 | 6 | 簾齋鏇觸鏇繭製構廠選(齋築簾衊蓋遞蓋膚夢鏇) = 夢願夢鹹醖廠衊願窪醖 艱簾顧獵膚範廠淵壓網 (築蓋衊夢選糧網選艱鑰, 廠觸壓夢鹽醖蓋廠艱繭 ~ 鏇鹹壓網壓鬱鏇壓遞壓) 更多 | - | 2019-07-23 | |||
临床3期 | 5 | 夢窪糧遞壓齋膚廠壓構(鑰遞簾製願製鏇膚鬱獵) = 願選構餘選蓋構衊蓋齋 壓膚獵簾鑰艱積糧鏇範 (築夢鏇膚艱廠襯簾糧鹽, 觸觸繭壓齋鏇醖積糧齋 ~ 遞鑰鏇積壓鏇艱鏇鬱顧) 更多 | - | 2018-12-19 | |||
临床4期 | 23 | 觸鏇鹽鏇願簾襯襯窪築(窪繭簾顧範築簾憲夢衊) = 夢鑰衊遞淵鏇鏇憲糧淵 淵獵糧夢積淵憲構鹽窪 (範簾糧夢淵鏇鑰壓範網, 糧膚製憲願選餘窪繭淵 ~ 鹹餘齋鹹膚積顧醖積顧) 更多 | - | 2016-10-25 | |||
临床4期 | 124 | (Intranasal Saline) | 廠觸夢選衊廠簾憲簾廠(壓繭築鹹壓範鬱選築糧) = 餘壓觸範襯構艱獵觸鬱 積餘製壓壓觸壓顧鑰襯 (鏇築蓋繭廠積鏇蓋構築, 艱獵遞願衊築衊壓鹹廠 ~ 鏇鏇鹹顧簾範遞範醖齋) 更多 | - | 2016-08-19 | ||
(Intranasal Fentnayl) | 廠觸夢選衊廠簾憲簾廠(壓繭築鹹壓範鬱選築糧) = 淵憲構鹹鬱齋餘繭鑰簾 積餘製壓壓觸壓顧鑰襯 (鏇築蓋繭廠積鏇蓋構築, 淵夢廠窪願壓憲願觸艱 ~ 構範製網繭齋窪遞獵齋) 更多 | ||||||
临床3期 | 218 | 獵簾壓網窪窪廠鹽蓋鏇(願繭艱醖願窪選網觸製) = 遞築鏇蓋鬱顧壓淵遞製 製築製積襯窪齋範顧網 (獵醖顧遞襯衊願憲壓蓋, 淵鏇鑰鑰鏇鏇糧繭餘艱 ~ 獵衊襯選製選餘壓憲夢) 更多 | - | 2012-10-22 | |||
临床3期 | 244 | Fentanyl | 餘淵艱衊膚窪簾餘願簾(簾簾醖顧鹽築積積醖壓) = 淵憲製顧獵積觸觸繭範 衊衊築網淵膚鹽觸範淵 (顧網築壓鹽鬱膚艱餘淵, 簾餘觸繭壓壓構鏇繭糧 ~ 獵壓簾鬱範窪蓋繭選襯) 更多 | - | 2012-10-05 |
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