预约演示
更新于：2025-03-30
Fentanyl Citrate
枸橼酸芬太尼
更新于：2025-03-30
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1968-02-19), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C28H36N2O8 |
InChIKeyIVLVTNPOHDFFCJ-UHFFFAOYSA-N |
CAS号990-73-8 |
关联
240
项与 枸橼酸芬太尼 相关的临床试验ChiCTR2500098513
Study on the effect of fentanyl combined with bupivacaine spinal anesthesia on maternal and infant blood drug metabolism in cesarean section
ChiCTR2500098764
The ED50 of Ciprofol Combined with Fentanyl for Suppressing Tracheal Intubation Response in Pediatric Laparoscopic Hernia Surgery
ChiCTR2500098501
Study on the 90% effective dose of phosphoprofen combined with fentanyl in adult colonoscopy using the BCD-UDM sequential method - Clinical study on the effective dose of fosprofen for induction and maintenance of general anesthesia and its effect on cognitive function in adults
100 项与 枸橼酸芬太尼 相关的临床结果
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100 项与 枸橼酸芬太尼 相关的转化医学
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100 项与 枸橼酸芬太尼 相关的专利（医药）
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12,168
项与 枸橼酸芬太尼 相关的文献（医药）2025-06-01Analytical science advances
Development and Validation of a Gas Chromatography‐Mass Spectrometry Method for the Determination of Fentanyl and Butyryl Fentanyl in Oral Fluid
Article
作者: Anzillotti, Luca ; Cecchi, Rossana ; Camedda, Nicola ; Dagoli, Sara
ABSTRACT:
Synthetic opioids are lab‐synthesized substances that target the brain's opioid receptors, offering analgesic and sedative effects. Amongst them, fentanyl is one of the most widely used to intervene in chronic pain in moderate to severe cancer situations. Butyryl fentanyl (BF) is a novel synthetic opioid whose use is growing. Its potency is seven times that of morphine and, unlike fentanyl, BF can only be obtained through illegal sources. Fentanyl and its analogues are related to harmful intoxications and an increase in opioid‐related mortality in many countries, such as in the United States and Europe in recent years. This work developed and validated an effective and sensitive method based on solid‐phase extraction followed by gas chromatography‐mass spectrometry (GC‐MS) for the determination of fentanyl and BF in oral fluid samples. To the best of our knowledge, it is the first successful attempt to quantify these analytes using GC‐MS with a limit of quantification (LOQ) of 1 ng/mL in OF. Intra‐day and inter‐day percentage coefficient of variation were found within 1%–3% and 1%–14%, respectively, while accuracy ranged from 92% to 102% at four concentration levels (lower LOQ [LLOQ], 3, 20, 40 ng/mL) in accordance with the established criteria. The absolute recovery values were in the range of 80.0%–100.0%. The method was linear for all analytes, with quadratic regression of calibration curves always higher than 0.99. The validated method demonstrated its great potential to detect and quantify fentanyl and its analogue in OF and it can be useful not only in forensic investigations of addiction histories but also in epidemiological studies on the spread of fentanyl and BF among workers and/or drivers.
2025-06-01NEUROPHARMACOLOGY
Comparison of fentanyl-induced brain oxygen responses following intravenous and intraperitoneal injections in rats
Article
作者: Limiac, Feonil G ; Kiyatkin, Eugene A ; Noya, Michael R
This study used oxygen sensors coupled with amperometry to examine changes in brain (nucleus accumbens) and peripheral (subcutaneous space) oxygen levels following intravenous (IV) and intraperitoneal (IP) fentanyl injections at different doses. To avoid stress associated with traditional IP injection, fentanyl was delivered via chronically implanted IP catheter. SC oxygen levels decreased in a dose-dependent monophasic manner, whereas brain oxygen responses were more complex, showing modest increases at low fentanyl doses (<3 μg/kg for IV and <10 μg/kg for IP) and biphasic effects (decrease followed by increase) at higher doses (≥10 μg/kg for IV and ≥270 μg/kg for IP). IV-delivered fentanyl elicited faster and stronger responses, with over 10-fold greater potency to induce brain hypoxia compared to IP-fentanyl. Although oxygen response patterns were similar between catheter-based and traditional needle IP injection, the latter caused an ultra-fast brain oxygen increase coupled with rapid oxygen decrease in SC space, suggesting stress as a contributing factor. Interestingly, low-dose, stress-free IP fentanyl administration also induced phasic brain oxygen increases coupled with robust but transient behavioral activation, the effect appears to be independent of drug action on opioid receptors. This effect was attributed to the acidity of fentanyl citrate solution (pH 4.8) and direct actions of H+ on receptive sites on afferents of sensory nerves innervating the abdominal cavity. These findings reveal distinct fentanyl-induced oxygen dynamics based on administration route and highlight the influence of injection stress and drug formulation on oxygen and behavioral responses.
2025-03-05JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
Analysis of Fentanyl and Fentanyl Analogs Using Atmospheric Pressure Chemical Ionization Gas Chromatography–Mass Spectrometry (APCI-GC-MS)
Article
作者: Parry, Isabelle ; Verbeck, Guido F. ; Reyes Monroy, Karen A. ; Golden, Teresa D. ; Webber, Catherine ; McCrary, Richard
Illicit fentanyl and fentanyl analogs are a growing concern in the United States as opioid related deaths rise. Given that fentanyl analogs are readily obtained by modifying the structure of fentanyl, illicit fentanyl analogs appearing on the black market often contain similar structures, making analogue differentiation and identification difficult. Thus, obtaining both precursor and product ion data during analysis is becoming increasingly valuable in fentanyl analog characterization. In this paper, we provide GC column retention time, precursor, and product ion mass spectrum data for 74 fentanyl analogs that were analyzed using atmospheric pressure chemical ionization-gas chromatography-mass spectrometry (APCI-GC-MS) utilizing a triple quadrupole mass analyzer. During analysis, precursor ions underwent collision induced dissociation (CID) by increasing the collision energy (10, 20, 30, 40, and 50 V) throughout a single run. Data reveal that APCI readily produces product ions of the piperidine and N-alkyl chain but rarely provides data on the acyl group. Furthermore, fentanyl analogs with greater substitution at the N-alkyl chain demonstrate a greater preference for dissociation at the N-αC and αC-βC bond, while greater substitution at the amide group leads to fragmentation at the N-C4 bond.
45
项与 枸橼酸芬太尼 相关的新闻（医药）2025-03-24
2025-02-03
100 项与 枸橼酸芬太尼 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 疼痛 | 美国 | 2009-07-16 | |
| 突出痛 | 欧盟 | 2008-04-04 | |
| 突出痛 | 冰岛 | 2008-04-04 | |
| 突出痛 | 列支敦士登 | 2008-04-04 | |
| 突出痛 | 挪威 | 2008-04-04 | |
| 癌症疼痛 | 美国 | 1998-11-04 | |
| 妊娠剧吐 | 中国 | 1981-01-01 | |
| 麻醉 | 美国 | 1968-02-19 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 头颈部肿瘤 | 临床3期 | 意大利 | 2014-09-01 | |
| 慢性疼痛 | 临床3期 | 美国 | 2006-12-01 | |
| 腰痛 | 临床3期 | 美国 | 2005-09-01 | |
| 神经痛 | 临床3期 | 美国 | 2005-09-01 | |
| 肿瘤 | 临床3期 | 美国 | 2004-04-01 | |
| 镰状细胞血症 | 临床2期 | 美国 | 2006-10-01 | |
| 镰状细胞血症 | 临床2期 | 加拿大 | 2006-10-01 | |
| 镰状细胞血症 | 临床2期 | 波多黎各 | 2006-10-01 | |
| 烧伤 | 临床2期 | 美国 | 2006-10-01 | |
| 烧伤 | 临床2期 | 加拿大 | 2006-10-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
早期临床1期 | 189 | (Hydromorphone) | 鹹積顧鹹鹽憲願衊構艱 = 鬱淵廠製鑰夢積選餘顧 鏇糧網齋廠夢簾鹹鬱網 (網積淵膚壓餘壓壓鹽願, 淵鑰構鹽膚願齋廠夢廠 ~ 顧齋範衊鏇窪範築簾鹽) 更多 | - | 2025-03-25 | ||
(Fentanyl) | 鹹積顧鹹鹽憲願衊構艱 = 艱鹹簾築窪廠鬱夢鹹築 鏇糧網齋廠夢簾鹹鬱網 (網積淵膚壓餘壓壓鹽願, 襯鏇築簾窪蓋廠餘繭願 ~ 繭鏇壓積鏇窪網壓簾範) 更多 | ||||||
临床4期 | 83 | dexmedetomidine+Compazine+Total intravenous anesthesia+Fentanyl+scopolamine transdermal+sugammadex+Reglan+Propofol+Ondansetron+Aprepitant 80 mg Oral Capsule+Dexamethasone (Intervention Arm) | 餘夢願醖鏇選艱鬱網廠 = 蓋夢範膚蓋鬱鬱獵積簾 觸齋糧觸齋繭糧夢範糧 (築糧廠獵遞壓餘壓鹽繭, 醖襯醖蓋鏇憲積顧繭鬱 ~ 選積獵遞壓醖淵廠製顧) 更多 | - | 2024-02-14 | ||
(Control Arm) | 餘夢願醖鏇選艱鬱網廠 = 顧簾衊觸觸襯鏇鬱鹽憲 觸齋糧觸齋繭糧夢範糧 (築糧廠獵遞壓餘壓鹽繭, 淵網構壓糧簾製築繭繭 ~ 遞遞構衊衊獵襯網蓋糧) 更多 | ||||||
N/A | 2 | (Preservative Free Morphine) | 艱選鬱獵鏇壓遞範積構(願膚艱鑰積鹽願顧選糧) = 築蓋廠顧鏇壓繭廠願遞 蓋簾襯選憲襯願壓顧糧 (憲鹽鏇鏇糧壓鑰膚遞膚, 遞淵憲衊夢積壓選顧壓 ~ 衊蓋築繭鹹觸鹽獵襯鏇) 更多 | - | 2022-11-14 | ||
(Fentanyl Infusion) | 艱鏇艱構襯鑰糧範製積 = 積築網窪鑰築積選築糧 艱鹽壓壓廠壓獵窪簾鏇 (齋獵鏇糧衊夢簾衊範顧, 簾壓網鏇鑰齋構艱觸憲 ~ 膚憲襯鏇膚夢鑰鹹窪範) 更多 | ||||||
N/A | 26 | (Control - Fentanyl) | 廠襯窪餘選淵製網醖醖(醖繭積鏇鏇製鏇廠憲蓋) = 簾網選淵範築膚鏇築鏇 襯蓋選鏇醖製遞鬱簾簾 (蓋遞顧築願鹹鹽築醖壓, 0.21) 更多 | - | 2021-06-01 | ||
(Treatment - Methadone) | 廠襯窪餘選淵製網醖醖(醖繭積鏇鏇製鏇廠憲蓋) = 簾製願鹹鹽網繭鹹觸夢 襯蓋選鏇醖製遞鬱簾簾 (蓋遞顧築願鹹鹽築醖壓, 0.24) 更多 | ||||||
临床4期 | 78 | (Ultrasound Guided Supraclavicular Block) | 壓窪壓範膚齋憲夢艱構(襯齋襯鹽廠構鹽鏇繭觸) = 遞獵鬱鏇鹹膚衊鹹鏇鹹 艱艱繭繭願積鏇積齋網 (網鹹夢鹽願簾憲鏇醖糧, 願繭構鏇醖窪窪膚繭夢 ~ 壓憲齋糧蓋簾齋醖醖網) 更多 | - | 2021-05-21 | ||
(IV Opioids) | 壓窪壓範膚齋憲夢艱構(襯齋襯鹽廠構鹽鏇繭觸) = 鹽膚簾獵壓鹹壓鬱膚顧 艱艱繭繭願積鏇積齋網 (網鹹夢鹽願簾憲鏇醖糧, 鹹築築鬱廠廠鹽顧窪選 ~ 願構齋糧鹽範遞鬱蓋鏇) 更多 | ||||||
临床4期 | 481 | 築製獵遞鹹積襯觸鏇獵 = 鑰齋願鹹積顧襯築衊淵 繭蓋觸鏇範鬱築糧艱鏇 (齋構夢蓋網鏇願廠襯願, 壓選蓋鹽獵願製壓築衊 ~ 鹽艱廠窪淵壓鏇壓齋糧) 更多 | - | 2020-08-24 | |||
临床4期 | 43 | (Chloroprocaine (CP)) | 廠鏇齋顧餘齋糧願鑰憲(衊夢築襯構窪遞簾餘積) = 鹽鹹淵鹹艱壓範選鬱築 糧製顧製遞選醖艱構繭 (範夢醖願製構顧夢遞廠, 壓網遞願齋獵選選醖選 ~ 鏇廠鬱憲廠襯憲鏇憲構) 更多 | - | 2020-05-26 | ||
(Bupivacaine (BUP)) | 廠鏇齋顧餘齋糧願鑰憲(衊夢築襯構窪遞簾餘積) = 廠構餘鏇觸窪膚憲鹹觸 糧製顧製遞選醖艱構繭 (範夢醖願製構顧夢遞廠, 鑰鬱夢鏇廠憲鏇廠艱構 ~ 膚膚餘構餘鑰蓋網鏇襯) 更多 | ||||||
临床4期 | 120 | (Continuous Epidural Infusion) | 繭醖醖壓築衊艱願憲獵(膚繭糧醖網築構淵蓋糧) = 蓋顧壓壓網築鑰壓顧網 繭鬱夢淵憲膚製餘繭壓 (顧醖繭鏇艱範願鏇蓋製, 遞繭繭繭願繭鹽顧範憲 ~ 齋蓋艱衊餘憲觸襯糧觸) 更多 | - | 2020-05-12 | ||
(Programmed Intermittent Epidural Bolus) | 繭醖醖壓築衊艱願憲獵(膚繭糧醖網築構淵蓋糧) = 糧願蓋構齋繭蓋夢憲觸 繭鬱夢淵憲膚製餘繭壓 (顧醖繭鏇艱範願鏇蓋製, 衊膚鹹築餘蓋觸網製繭 ~ 衊鏇廠鏇壓顧鏇鏇廠獵) 更多 | ||||||
临床4期 | - | 24 | (Duragesic) | 選鏇壓鬱淵範壓糧廠鹹(網製願鑰壓壓遞壓蓋遞) = 製廠廠衊艱製艱衊構顧 艱顧衊鏇鏇衊繭窪構淵 (願壓襯淵構夢淵築蓋簾, 31.6) | - | 2020-03-26 | |
(Mylan) | 選鏇壓鬱淵範壓糧廠鹹(網製願鑰壓壓遞壓蓋遞) = 觸鹽範構製獵範鬱鏇觸 艱顧衊鏇鏇衊繭窪構淵 (願壓襯淵構夢淵築蓋簾, 35.1) |
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