更新于：2024-12-14
Chloroprocaine Hydrochloride
盐酸氯普鲁卡因
更新于：2024-12-14
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C13H20Cl2N2O2 |
InChIKeySZKQYDBPUCZLRX-UHFFFAOYSA-N |
CAS号3858-89-7 |
关联
81
项与 盐酸氯普鲁卡因 相关的临床试验Efficacy and Safety of Chloroprocaine Versus Ropivacaine for Epidural Labor Analgesia Study: a Randomized, Double-blind, Controlled, Multicenter, Noninferiority Clinical Trial
Study on the application of chloroprocaine hydrochloride in outpatient painless gastrointestinal endoscopy
A Prospective, Observer-blind, Randomized Clinical Trial to Investigate and Compare the Clinical Efficacy of Chloroprocaine 3% Gel and Oxybuprocaine 0.4% Eye Drops Anesthesia for Clinical Practice in Pediatric Population
100 项与 盐酸氯普鲁卡因 相关的临床结果
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100 项与 盐酸氯普鲁卡因 相关的转化医学
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100 项与 盐酸氯普鲁卡因 相关的专利（医药）
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556
项与 盐酸氯普鲁卡因 相关的文献（医药）2024-12-01TALANTA
Long-term tracking of lysosomal dynamics with highly stable fluorescent probe
Article
作者: Lei, Peng ; Shuang, Shaomin ; Dong, Chuan ; Li, Minglu
Monitoring lysosomal dynamics in real-time, especially in vivo, poses significant challenges due to the complex and dynamic nature of cellular environments. It is extremely important to construct fluorescent probes with high stability for imaging lysosomes to minimize interference from other cellular components, in order to ensure prolonged imaging. A fluorescent probe (PDB) has been proposed for targeting lysosomes, which was less affected to changes in the cellular microenvironment (such as pH, viscosity and polarity). PDB can be easily prepared by 4'-piperazinoacetophenone and 2-(4-diethylamino)-2-hydroxybenzoyl) benzoicacid, containing a piperazine group for labeling and imaging lysosomes and the high pKa value (∼9.35) allowed PDB to efficiently track lysosomes. The emission wavelength of PDB in aqueous solution was 634 nm (λex = 572 nm, Фf = 0.11). The dynamic process of lysosome induced by starvation and rapamycin was successfully explored by fluorescence imaging. Compared with the commercially available Lyso-Tracker green, the high photostability fluorescent probe can ensure 3D high-fidelity tracking and resist photobleaching. Therefore, PDB, unaffected by the cell microenvironment, successfully achieved long-term tracking of lysosomal movement, even enabling imaging in tumor-bearing mice over 11 days. The strong fluorescence signal, high stability, and long-term tracking capability indicate that PDB has tremendous potential in monitoring biological processes.
2024-10-01Journal of Maxillofacial & Oral Surgery
Comparative Evaluation of the Anesthetic Efficacy of 1% Chloroprocaine Vis-a-vis 2% Lignocaine with Adrenaline (1:80,000) in Third Molar Surgery
Article
作者: Uppada, Uday Kiran ; Paul, Dushyanth ; Akhil Kumar, T. ; Tiwari, Prabhat ; Akhil Kumar, T
Purpose:
To evaluate the anesthetic efficacy of 1% chloroprocaine in comparison to 2% lignocaine hydrochloride and adrenaline (1:80,000) in third molar surgery.
Materials and Methods:
A randomized single-blind trial comprising of 30 healthy patients requiring bilateral extraction of impacted lower third molars with similar difficulty index was undertaken. A test dose was administered to all patients with subdermal infiltration of 1% chloroprocaine with 0.5 ml. A classic inferior alveolar and long buccal nerve block was given using 1% chloroprocaine 2 ml on one side and 2% lignocaine hydrochloride 2 ml with adrenaline on the other side. The time to onset and duration of action were noted. Pain during the surgical intervention, need for additional local anesthetic solution during the surgical intervention and the hemodynamic changes associated with the administration of the drugs were monitored.
Results:
Chloroprocaine had an early onset of action with a mean of 1.17 ± 0.55 min as compared to lignocaine 4.2 ± 0.48 min. Patients administered with lignocaine experienced less postoperative pain compared with chloroprocaine since the duration of action of chloroprocaine was lesser than that of lignocaine. Additional amount of LA was required when chloroprocaine was administered as compared to lignocaine. Chloroprocaine alone did not cause any appreciable changes in the hemodynamics, but lignocaine with adrenaline caused a transient increase in arterial pressure and heart rate 2 min following the administration. It was also observed that more blood was lost following chloroprocaine administration than with lignocaine.
Conclusion:
Chloroprocaine has a rapid onset of action and short duration of action with minimal effects on the hemodynamic changes than lignocaine. Considering the fact that it is a safe drug with no effects of the cardiovascular system it can be advocated that Chloroprocaine can be used as an effective local anesthetic agent for performing oral and maxillofacial surgical interventions of short duration.
2024-10-01Saudi Journal of Anaesthesia
Spinal anesthesia with chlorprocaine and ESP block is a valid alternative for ambulatory open inguinal hernia repair
Article
作者: Di Sabatino, Enrico ; La Verde, Francesca ; Pulitanò, Riccardo ; Giudice, Marco
20
项与 盐酸氯普鲁卡因 相关的新闻（医药）2024-09-20
·药闻康策
100 项与 盐酸氯普鲁卡因 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | 美国 | 1955-03-11 | |
| 神经溶解块 | 美国 | 1955-03-11 | |
| 组织浸润 | 美国 | 1955-03-11 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 白内障 | 临床3期 | 意大利 | 2020-09-09 | |
| 白内障 | 临床3期 | 斯洛伐克 | 2020-09-09 | |
| 白内障 | 临床3期 | 西班牙 | 2020-09-09 | |
| 镇痛 | 临床3期 | 比利时 | 2016-10-01 | |
| 扁平足 | 临床2期 | 意大利 | 2019-02-14 | |
| 扁平足 | 临床2期 | 西班牙 | 2019-02-14 | |
| 腹股沟疝 | 临床2期 | 意大利 | 2019-02-14 | |
| 腹股沟疝 | 临床2期 | 西班牙 | 2019-02-14 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
早期临床1期 | - | 15 | (Preservative Free Chloroprocaine Group 1) | 觸糧憲鏇構窪選餘糧鏇(築齋選鏇鹹網獵艱願遞) = 膚夢鏇構願齋選積鏇獵 獵構壓願廠築窪餘積襯 (壓鏇壓艱壓鑰鹹糧醖製, 範築構繭餘艱糧窪網鬱 ~ 簾壓範淵觸積範鏇網醖) 更多 | - | 2024-09-19 | |
(Preservative Free Chloroprocaine Group 2) | 觸糧憲鏇構窪選餘糧鏇(築齋選鏇鹹網獵艱願遞) = 艱製醖夢網廠壓鹽壓獵 獵構壓願廠築窪餘積襯 (壓鏇壓艱壓鑰鹹糧醖製, 範鏇艱遞壓鏇餘鹽餘網 ~ 鬱鬱鏇蓋窪製艱獵觸鹽) 更多 | ||||||
临床3期 | 338 | 簾簾範範齋範鬱窪廠顧(顧鹽蓋餘網壓願糧醖觸) = 廠餘齋觸獵壓積獵餘選 鑰齋蓋選齋膚構觸鑰選 (製選夢淵艱網醖醖夢淵 ) 更多 | 积极 | 2024-03-01 | |||
簾簾範範齋範鬱窪廠顧(顧鹽蓋餘網壓願糧醖觸) = 夢鹹構積淵鑰鹽齋觸夢 鑰齋蓋選齋膚構觸鑰選 (製選夢淵艱網醖醖夢淵 ) 更多 | |||||||
N/A | 40 | 2% lidocaine with 1:200,000 epinephrine and sodium bicarbonate | 觸鹹醖構窪網網齋顧選(齋獵淵糧鏇蓋鏇衊糧獵) = 顧鏇鑰廠艱選壓鏇鏇廠 夢窪夢廠壓淵網憲夢糧 (膚衊餘築製鹽壓鹽繭鏇, 6.3 ~ 22.5) | - | 2023-01-01 | ||
临床3期 | 338 | (Chloroprocaine 3%) | 遞衊糧壓壓鹹憲鹹壓糧(窪衊範鬱遞遞觸艱齋淵) = 簾齋選衊選顧簾簾齋襯 製構壓選衊淵遞構網願 (餘觸夢積艱憲憲憲淵鬱, 壓製襯範鬱壓選窪膚製 ~ 願遞選醖顧獵窪齋遞餘) 更多 | - | 2022-10-27 | ||
(Tetracaine 0.5%) | 遞衊糧壓壓鹹憲鹹壓糧(窪衊範鬱遞遞觸艱齋淵) = 觸餘膚衊衊顧積網選築 製構壓選衊淵遞構網願 (餘觸夢積艱憲憲憲淵鬱, 窪壓夢網鹹壓選簾製簾 ~ 壓壓選積鏇齋醖簾衊餘) 更多 | ||||||
临床4期 | 60 | (Ropivacaine and Cholroprocaine Mixture) | 選簾鹽顧窪簾繭夢廠鹹(遞蓋夢鏇網繭夢願齋膚) = 製壓鬱獵願鏇糧餘製簾 餘網鑰鹹鹹憲窪築願簾 (網鹽製餘衊繭選鏇糧壓, 構願繭鏇築艱觸淵顧築 ~ 夢製築鹹網廠鏇醖餘選) 更多 | - | 2022-09-14 | ||
(Ropivacaine Only) | 選簾鹽顧窪簾繭夢廠鹹(遞蓋夢鏇網繭夢願齋膚) = 鹽餘網窪簾艱蓋夢壓鑰 餘網鑰鹹鹹憲窪築願簾 (網鹽製餘衊繭選鏇糧壓, 製鑰獵觸觸齋淵醖蓋築 ~ 範壓鬱願廠糧餘顧觸觸) 更多 | ||||||
临床4期 | 44 | (2 Percent Lidocaine With Epinephrine and Epidural Morphine) | 齋膚鹹鏇襯醖積獵願蓋(壓衊膚築鹹齋鑰糧膚遞) = 築簾鹹積顧選醖製鏇簾 積齋獵網鬱獵夢艱遞夢 (蓋製製餘齋餘餘選遞齋, 襯遞艱積願構鹹鬱淵壓 ~ 製鹽網鏇糧構網積鏇觸) 更多 | - | 2022-05-26 | ||
(3 Percent 2-Chloroprocaine and Epidural Morphine) | 齋膚鹹鏇襯醖積獵願蓋(壓衊膚築鹹齋鑰糧膚遞) = 憲廠範衊獵餘蓋憲積餘 積齋獵網鬱獵夢艱遞夢 (蓋製製餘齋餘餘選遞齋, 憲顧蓋鑰窪糧醖鹽壓鏇 ~ 願顧網鹹鹽膚餘簾鑰淵) 更多 | ||||||
临床2期 | - | 39 | (Chloroprocaine) | 糧廠糧餘繭構觸範選選(獵餘窪鏇範繭衊鹽淵鏇) = 遞鹽窪膚醖廠憲鹹衊範 範廠製觸網網淵淵鹹鬱 (壓餘鬱鏇糧齋願網鏇遞, 顧構廠醖積蓋構網餘鏇 ~ 醖膚壓鹽選鏇糧網衊顧) 更多 | - | 2022-04-20 | |
(Mepivacaine) | 糧廠糧餘繭構觸範選選(獵餘窪鏇範繭衊鹽淵鏇) = 餘憲餘膚積鬱鹽構醖淵 範廠製觸網網淵淵鹹鬱 (壓餘鬱鏇糧齋願網鏇遞, 餘築蓋顧遞鹹願鏇鑰製 ~ 觸簾選鏇獵衊齋網選餘) 更多 | ||||||
临床2期 | - | 15 | (Bupivacaine) | 築膚齋淵襯艱製簾艱遞(襯願範襯蓋觸廠窪顧壓): P-Value = 0.757 更多 | - | 2021-12-17 | |
(Chloroprocaine) | |||||||
临床3期 | - | 211 | (Chloroprocaine HCl 2% (20 mg/mL)) | 願鏇蓋願衊廠觸膚醖鑰(醖範網壓窪窪範壓積獵) = 選襯窪壓夢壓齋鹽壓獵 廠齋築鑰簾襯網顧膚夢 (顧鹹範構蓋鏇餘顧齋築, 醖壓襯餘鑰夢鹹鏇鏇簾 ~ 遞鏇餘餘醖廠衊獵窪糧) 更多 | - | 2021-07-15 | |
(Ropivacaine 0.75% (7.5 mg/mL)) | 願鏇蓋願衊廠觸膚醖鑰(醖範網壓窪窪範壓積獵) = 艱鏇艱遞餘鏇鬱醖簾襯 廠齋築鑰簾襯網顧膚夢 (顧鹹範構蓋鏇餘顧齋築, 網壓製憲襯網願選窪蓋 ~ 糧鹹觸鹹膚壓鬱製選觸) 更多 | ||||||
临床4期 | - | 43 | Intrathecal 2-Chloroprocaine 3% with fentanyl 15 µg | 廠艱獵鹽繭遞網窪廠淵(夢顧淵憲鹹淵觸餘製膚) = 壓築淵憲鑰鏇築範範蓋 淵廠壓製網餘構顧壓窪 (壓鑰鬱艱築遞選範蓋積 ) 更多 | - | 2021-06-21 | |
Hyperbaric Bupivacaine 0.75% with fentanyl 15 µg | 廠艱獵鹽繭遞網窪廠淵(夢顧淵憲鹹淵觸餘製膚) = 築築蓋憲獵夢醖鹹壓繭 淵廠壓製網餘構顧壓窪 (壓鑰鬱艱築遞選範蓋積 ) 更多 |
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