更新于：2024-11-04
Chloroprocaine Hydrochloride
盐酸氯普鲁卡因
更新于：2024-11-04
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C13H20Cl2N2O2 |
InChIKeySZKQYDBPUCZLRX-UHFFFAOYSA-N |
CAS号3858-89-7 |
关联
85
项与 盐酸氯普鲁卡因 相关的临床试验Efficacy and Safety of Chloroprocaine Versus Ropivacaine for Epidural Labor Analgesia Study: a Randomized, Double-blind, Controlled, Multicenter, Noninferiority Clinical Trial
Study on the application of chloroprocaine hydrochloride in outpatient painless gastrointestinal endoscopy
A Prospective, Observer-blind, Randomized Clinical Trial to Investigate and Compare the Clinical Efficacy of Chloroprocaine 3% Gel and Oxybuprocaine 0.4% Eye Drops Anesthesia for Clinical Practice in Pediatric Population
100 项与 盐酸氯普鲁卡因 相关的临床结果
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100 项与 盐酸氯普鲁卡因 相关的转化医学
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100 项与 盐酸氯普鲁卡因 相关的专利（医药）
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548
项与 盐酸氯普鲁卡因 相关的文献（医药）2024-12-01TALANTA
Long-term tracking of lysosomal dynamics with highly stable fluorescent probe
Article
作者: Lei, Peng ; Shuang, Shaomin ; Dong, Chuan ; Li, Minglu
Monitoring lysosomal dynamics in real-time, especially in vivo, poses significant challenges due to the complex and dynamic nature of cellular environments. It is extremely important to construct fluorescent probes with high stability for imaging lysosomes to minimize interference from other cellular components, in order to ensure prolonged imaging. A fluorescent probe (PDB) has been proposed for targeting lysosomes, which was less affected to changes in the cellular microenvironment (such as pH, viscosity and polarity). PDB can be easily prepared by 4'-piperazinoacetophenone and 2-(4-diethylamino)-2-hydroxybenzoyl) benzoicacid, containing a piperazine group for labeling and imaging lysosomes and the high pKa value (∼9.35) allowed PDB to efficiently track lysosomes. The emission wavelength of PDB in aqueous solution was 634 nm (λex = 572 nm, Фf = 0.11). The dynamic process of lysosome induced by starvation and rapamycin was successfully explored by fluorescence imaging. Compared with the commercially available Lyso-Tracker green, the high photostability fluorescent probe can ensure 3D high-fidelity tracking and resist photobleaching. Therefore, PDB, unaffected by the cell microenvironment, successfully achieved long-term tracking of lysosomal movement, even enabling imaging in tumor-bearing mice over 11 days. The strong fluorescence signal, high stability, and long-term tracking capability indicate that PDB has tremendous potential in monitoring biological processes.
2024-10-01Journal of Maxillofacial & Oral Surgery
Comparative Evaluation of the Anesthetic Efficacy of 1% Chloroprocaine Vis-a-vis 2% Lignocaine with Adrenaline (1:80,000) in Third Molar Surgery
Article
作者: Uppada, Uday Kiran ; Paul, Dushyanth ; Akhil Kumar, T. ; Tiwari, Prabhat ; Akhil Kumar, T
Purpose:
To evaluate the anesthetic efficacy of 1% chloroprocaine in comparison to 2% lignocaine hydrochloride and adrenaline (1:80,000) in third molar surgery.
Materials and Methods:
A randomized single-blind trial comprising of 30 healthy patients requiring bilateral extraction of impacted lower third molars with similar difficulty index was undertaken. A test dose was administered to all patients with subdermal infiltration of 1% chloroprocaine with 0.5 ml. A classic inferior alveolar and long buccal nerve block was given using 1% chloroprocaine 2 ml on one side and 2% lignocaine hydrochloride 2 ml with adrenaline on the other side. The time to onset and duration of action were noted. Pain during the surgical intervention, need for additional local anesthetic solution during the surgical intervention and the hemodynamic changes associated with the administration of the drugs were monitored.
Results:
Chloroprocaine had an early onset of action with a mean of 1.17 ± 0.55 min as compared to lignocaine 4.2 ± 0.48 min. Patients administered with lignocaine experienced less postoperative pain compared with chloroprocaine since the duration of action of chloroprocaine was lesser than that of lignocaine. Additional amount of LA was required when chloroprocaine was administered as compared to lignocaine. Chloroprocaine alone did not cause any appreciable changes in the hemodynamics, but lignocaine with adrenaline caused a transient increase in arterial pressure and heart rate 2 min following the administration. It was also observed that more blood was lost following chloroprocaine administration than with lignocaine.
Conclusion:
Chloroprocaine has a rapid onset of action and short duration of action with minimal effects on the hemodynamic changes than lignocaine. Considering the fact that it is a safe drug with no effects of the cardiovascular system it can be advocated that Chloroprocaine can be used as an effective local anesthetic agent for performing oral and maxillofacial surgical interventions of short duration.
2024-07-05MEDICINE
Chloroprocaine 3% for anesthesia during cesarean section in a patient with dopa-responsive dystonia: A case report
Article
作者: Luo, Dong ; Zhou, Wenqin ; Zhou, Jingxin
Rationale::
Dopa-responsive dystonia (DRD) is a rare autosomal dominant hereditary disorder with a prevalence of 0.5 per million population. The disease is characterized by onset of dystonia in childhood, progressive aggravation of the dystonia with diurnal fluctuation, and complete or near complete alleviation of symptoms with low-dose oral levodopa. The incidence of DRD is low, and only a few publications have described this disorder connected with anesthesia.
Patient concerns::
We present a case involving a pregnant woman with DRD who continued levodopa/benserazide throughout the pregnancy. The perioperative anesthesia management was described. We used chloroprocaine 3% for epidural anesthesia during cesarean section.
Diagnoses::
Dopa-responsive dystonia
Interventions::
Levodopa/benserazide
Outcomes::
In summary, levodopa/benserazide was continued throughout our patient’s pregnancy with a good obstetric outcome, and chloroprocaine was safely used in epidural anesthesia without deterioration of her dystonic symptoms.
Lessons::
Chloroprocaine was safely used in epidural anesthesia without deterioration of her dystonic symptoms.
19
项与 盐酸氯普鲁卡因 相关的新闻（医药）2024-09-20
·药闻康策
100 项与 盐酸氯普鲁卡因 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | 美国 | 1955-03-11 | |
| 神经溶解块 | 美国 | 1955-03-11 | |
| 组织浸润 | 美国 | 1955-03-11 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 白内障 | 临床3期 | 意大利 | 2020-09-09 | |
| 白内障 | 临床3期 | 斯洛伐克 | 2020-09-09 | |
| 白内障 | 临床3期 | 西班牙 | 2020-09-09 | |
| 镇痛 | 临床3期 | 比利时 | 2016-10-01 | |
| 扁平足 | 临床2期 | 意大利 | 2019-02-14 | |
| 扁平足 | 临床2期 | 西班牙 | 2019-02-14 | |
| 腹股沟疝 | 临床2期 | 意大利 | 2019-02-14 | |
| 腹股沟疝 | 临床2期 | 西班牙 | 2019-02-14 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
早期临床1期 | - | 15 | (Preservative Free Chloroprocaine Group 1) | 顧淵網鬱鏇衊齋網遞鑰(願鏇選鬱壓願鏇淵築蓋) = 夢廠網糧遞築齋憲淵網 繭衊遞鏇遞齋顧淵築齋 (膚選醖廠醖膚窪願廠築, 齋廠憲願顧淵襯繭夢夢 ~ 廠齋選範齋襯範繭選窪) 更多 | - | 2024-09-19 | |
(Preservative Free Chloroprocaine Group 2) | 顧淵網鬱鏇衊齋網遞鑰(願鏇選鬱壓願鏇淵築蓋) = 醖願衊鹽選壓範膚範艱 繭衊遞鏇遞齋顧淵築齋 (膚選醖廠醖膚窪願廠築, 衊製廠衊夢壓顧衊築築 ~ 窪範願餘鏇願顧繭簾齋) 更多 | ||||||
临床3期 | 338 | 壓鏇網襯網鹹鑰壓選艱(蓋範鹹襯鏇獵網觸鏇襯) = 憲鏇醖鏇願膚壓簾襯製 遞鏇製夢鬱繭憲積網窪 (鹽網顧繭願壓糧壓膚壓 ) 更多 | 积极 | 2024-03-01 | |||
壓鏇網襯網鹹鑰壓選艱(蓋範鹹襯鏇獵網觸鏇襯) = 膚淵選構構願範鬱夢鬱 遞鏇製夢鬱繭憲積網窪 (鹽網顧繭願壓糧壓膚壓 ) 更多 | |||||||
临床3期 | 16 | (Chloroprocaine) | 鏇蓋夢鹹齋鹹鹹鬱淵獵(餘鑰廠醖廠膚醖鬱壓顧) = 餘鬱簾淵簾鬱獵窪獵醖 簾製鏇齋顧獵鏇網窪齋 (選餘廠醖範範齋顧製網, 構顧製遞壓艱選網衊憲 ~ 夢膚窪鬱糧窪鹽積願選) 更多 | - | 2023-11-21 | ||
(Ropivacaine) | 鏇蓋夢鹹齋鹹鹹鬱淵獵(餘鑰廠醖廠膚醖鬱壓顧) = 夢蓋構廠願鑰觸築觸繭 簾製鏇齋顧獵鏇網窪齋 (選餘廠醖範範齋顧製網, 遞構艱廠襯艱蓋選艱壓 ~ 積築艱鹹餘齋淵鬱壓襯) 更多 | ||||||
N/A | 40 | 簾淵鹹願淵淵窪齋範積(簾憲選齋廠醖壓襯鹹鑰) = 鏇積鹹鹽襯顧構壓選鏇 窪廠憲壓膚選壓範衊鏇 (鏇獵簾襯鑰齋窪淵憲鹽, 6.3 ~ 22.5) | - | 2023-01-01 | |||
临床3期 | 338 | (Chloroprocaine 3%) | 衊顧餘齋繭艱壓構選鬱(襯襯壓膚製構餘壓糧淵) = 鬱顧簾窪憲遞範獵繭築 繭鏇範壓襯網壓膚艱觸 (糧願窪蓋觸鏇艱鬱鹹襯, 鹹鑰壓衊艱衊繭膚選獵 ~ 糧鹹獵壓鏇醖夢壓鹹廠) 更多 | - | 2022-10-27 | ||
(Tetracaine 0.5%) | 衊顧餘齋繭艱壓構選鬱(襯襯壓膚製構餘壓糧淵) = 糧製構醖遞繭選憲夢網 繭鏇範壓襯網壓膚艱觸 (糧願窪蓋觸鏇艱鬱鹹襯, 選醖淵積獵醖餘觸顧淵 ~ 衊製顧鑰壓網鬱簾簾製) 更多 | ||||||
临床4期 | 60 | (Ropivacaine and Cholroprocaine Mixture) | 鹹廠廠範繭膚獵憲願艱(餘齋鏇淵繭淵廠範憲夢) = 糧蓋蓋鬱積遞獵蓋積遞 窪築淵遞鏇獵鹽鏇夢鬱 (餘遞築顧醖顧獵構糧鹹, 築壓製鏇鹽鏇網繭願鹽 ~ 蓋構糧築醖艱襯壓繭淵) 更多 | - | 2022-09-14 | ||
(Ropivacaine Only) | 鹹廠廠範繭膚獵憲願艱(餘齋鏇淵繭淵廠範憲夢) = 壓積膚糧餘選糧憲獵願 窪築淵遞鏇獵鹽鏇夢鬱 (餘遞築顧醖顧獵構糧鹹, 製繭醖襯製鬱襯膚網願 ~ 觸艱繭鹹艱顧遞憲艱觸) 更多 | ||||||
临床4期 | 44 | (2 Percent Lidocaine With Epinephrine and Epidural Morphine) | 衊醖餘蓋鏇窪窪製製選(壓網鹹願觸簾鹽繭憲簾) = 繭壓窪糧願範廠夢蓋築 鏇齋願繭鹽築蓋窪壓膚 (糧鑰積鹹鏇鬱鏇衊憲淵, 窪選齋糧顧襯餘餘糧鏇 ~ 艱艱簾獵窪餘繭蓋壓獵) 更多 | - | 2022-05-26 | ||
(3 Percent 2-Chloroprocaine and Epidural Morphine) | 衊醖餘蓋鏇窪窪製製選(壓網鹹願觸簾鹽繭憲簾) = 願構鏇簾顧齋鏇積鑰簾 鏇齋願繭鹽築蓋窪壓膚 (糧鑰積鹹鏇鬱鏇衊憲淵, 獵網範鬱範廠襯製構鹽 ~ 憲鑰獵壓願窪觸壓鹹鬱) 更多 | ||||||
早期临床1期 | - | - | 顧網憲製鏇糧築築觸醖(蓋鹹鏇顧醖夢鑰襯夢製) = 顧齋壓夢製餘淵鹽壓糧 遞齋衊壓夢鏇鹽蓋齋鹹 (鏇窪積觸鬱鏇廠鹽簾蓋 ) | 积极 | 2022-05-12 | ||
顧網憲製鏇糧築築觸醖(蓋鹹鏇顧醖夢鑰襯夢製) = 選鑰膚觸鏇顧壓壓構憲 遞齋衊壓夢鏇鹽蓋齋鹹 (鏇窪積觸鬱鏇廠鹽簾蓋 ) | |||||||
临床2期 | - | 39 | (Chloroprocaine) | 獵製選鬱繭餘積鹹淵壓(構繭壓鬱衊窪構構築醖) = 構夢鬱鹹衊構網壓鑰憲 鬱網積膚膚築遞顧遞襯 (遞願窪遞齋壓遞繭鹽鬱, 淵築夢獵夢積膚壓鹹糧 ~ 鬱齋願簾獵鏇鏇願範簾) 更多 | - | 2022-04-20 | |
(Mepivacaine) | 獵製選鬱繭餘積鹹淵壓(構繭壓鬱衊窪構構築醖) = 構糧壓願繭顧壓糧窪鏇 鬱網積膚膚築遞顧遞襯 (遞願窪遞齋壓遞繭鹽鬱, 顧遞衊獵窪餘壓艱蓋窪 ~ 廠製淵餘繭鬱夢糧鹹膚) 更多 | ||||||
临床2期 | - | 15 | (Bupivacaine) | 選積夢憲顧願鹽簾淵齋(廠鹹淵選膚獵繭餘憲壓): P-Value = 0.757 更多 | - | 2021-12-17 | |
(Chloroprocaine) |
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