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更新于：2024-12-27
Chloroprocaine Hydrochloride
盐酸氯普鲁卡因
更新于：2024-12-27
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C13H20Cl2N2O2 |
InChIKeySZKQYDBPUCZLRX-UHFFFAOYSA-N |
CAS号3858-89-7 |
关联
81
项与 盐酸氯普鲁卡因 相关的临床试验NCT06472232
Efficacy and Safety of Chloroprocaine Versus Ropivacaine for Epidural Labor Analgesia Study: a Randomized, Double-blind, Controlled, Multicenter, Noninferiority Clinical Trial
ChiCTR2400085739
Study on the application of chloroprocaine hydrochloride in outpatient painless gastrointestinal endoscopy
CTIS2023-504477-21-01
A prospective, observer-blind, randomized clinical trial to investigate and compare the clinical efficacy of Chloroprocaine 3% gel and Oxybuprocaine 0.4% eye drops anesthesia for clinical practice in pediatric population. - CHL.3-01-2021-M
100 项与 盐酸氯普鲁卡因 相关的临床结果
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100 项与 盐酸氯普鲁卡因 相关的转化医学
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100 项与 盐酸氯普鲁卡因 相关的专利（医药）
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555
项与 盐酸氯普鲁卡因 相关的文献（医药）2024-12-01TALANTA
Long-term tracking of lysosomal dynamics with highly stable fluorescent probe
Article
作者: Lei, Peng ; Shuang, Shaomin ; Dong, Chuan ; Li, Minglu
Monitoring lysosomal dynamics in real-time, especially in vivo, poses significant challenges due to the complex and dynamic nature of cellular environments. It is extremely important to construct fluorescent probes with high stability for imaging lysosomes to minimize interference from other cellular components, in order to ensure prolonged imaging. A fluorescent probe (PDB) has been proposed for targeting lysosomes, which was less affected to changes in the cellular microenvironment (such as pH, viscosity and polarity). PDB can be easily prepared by 4'-piperazinoacetophenone and 2-(4-diethylamino)-2-hydroxybenzoyl) benzoicacid, containing a piperazine group for labeling and imaging lysosomes and the high pKa value (∼9.35) allowed PDB to efficiently track lysosomes. The emission wavelength of PDB in aqueous solution was 634 nm (λex = 572 nm, Фf = 0.11). The dynamic process of lysosome induced by starvation and rapamycin was successfully explored by fluorescence imaging. Compared with the commercially available Lyso-Tracker green, the high photostability fluorescent probe can ensure 3D high-fidelity tracking and resist photobleaching. Therefore, PDB, unaffected by the cell microenvironment, successfully achieved long-term tracking of lysosomal movement, even enabling imaging in tumor-bearing mice over 11 days. The strong fluorescence signal, high stability, and long-term tracking capability indicate that PDB has tremendous potential in monitoring biological processes.
2024-10-01Journal of Maxillofacial & Oral Surgery
Comparative Evaluation of the Anesthetic Efficacy of 1% Chloroprocaine Vis-a-vis 2% Lignocaine with Adrenaline (1:80,000) in Third Molar Surgery
Article
作者: Uppada, Uday Kiran ; Paul, Dushyanth ; Akhil Kumar, T. ; Tiwari, Prabhat ; Akhil Kumar, T
Purpose:
To evaluate the anesthetic efficacy of 1% chloroprocaine in comparison to 2% lignocaine hydrochloride and adrenaline (1:80,000) in third molar surgery.
Materials and Methods:
A randomized single-blind trial comprising of 30 healthy patients requiring bilateral extraction of impacted lower third molars with similar difficulty index was undertaken. A test dose was administered to all patients with subdermal infiltration of 1% chloroprocaine with 0.5 ml. A classic inferior alveolar and long buccal nerve block was given using 1% chloroprocaine 2 ml on one side and 2% lignocaine hydrochloride 2 ml with adrenaline on the other side. The time to onset and duration of action were noted. Pain during the surgical intervention, need for additional local anesthetic solution during the surgical intervention and the hemodynamic changes associated with the administration of the drugs were monitored.
Results:
Chloroprocaine had an early onset of action with a mean of 1.17 ± 0.55 min as compared to lignocaine 4.2 ± 0.48 min. Patients administered with lignocaine experienced less postoperative pain compared with chloroprocaine since the duration of action of chloroprocaine was lesser than that of lignocaine. Additional amount of LA was required when chloroprocaine was administered as compared to lignocaine. Chloroprocaine alone did not cause any appreciable changes in the hemodynamics, but lignocaine with adrenaline caused a transient increase in arterial pressure and heart rate 2 min following the administration. It was also observed that more blood was lost following chloroprocaine administration than with lignocaine.
Conclusion:
Chloroprocaine has a rapid onset of action and short duration of action with minimal effects on the hemodynamic changes than lignocaine. Considering the fact that it is a safe drug with no effects of the cardiovascular system it can be advocated that Chloroprocaine can be used as an effective local anesthetic agent for performing oral and maxillofacial surgical interventions of short duration.
2024-10-01Saudi Journal of Anaesthesia
Spinal anesthesia with chlorprocaine and ESP block is a valid alternative for ambulatory open inguinal hernia repair
Article
作者: Di Sabatino, Enrico ; La Verde, Francesca ; Pulitanò, Riccardo ; Giudice, Marco
20
项与 盐酸氯普鲁卡因 相关的新闻（医药）2024-09-20
·药闻康策
100 项与 盐酸氯普鲁卡因 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | 美国 | 1955-03-11 | |
| 神经阻滞 | 美国 | 1955-03-11 | |
| 组织浸润 | 美国 | 1955-03-11 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 白内障 | 临床3期 | 意大利 | 2020-09-09 | |
| 白内障 | 临床3期 | 斯洛伐克 | 2020-09-09 | |
| 白内障 | 临床3期 | 西班牙 | 2020-09-09 | |
| 镇痛 | 临床3期 | 比利时 | 2016-10-01 | |
| 扁平足 | 临床2期 | 意大利 | 2019-02-14 | |
| 扁平足 | 临床2期 | 西班牙 | 2019-02-14 | |
| 腹股沟疝 | 临床2期 | 意大利 | 2019-02-14 | |
| 腹股沟疝 | 临床2期 | 西班牙 | 2019-02-14 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
早期临床1期 | - | 15 | (Preservative Free Chloroprocaine Group 1) | 簾網鏇憲鹽夢鏇夢簾艱(鏇餘獵醖壓鬱繭廠簾廠) = 憲鹹衊壓鏇憲廠糧淵構 製築鬱遞衊艱獵網積願 (鑰製獵遞鬱夢獵齋鬱製, 遞鹹範鹽淵衊選艱築選 ~ 襯糧簾鹹願顧網繭遞夢) 更多 | - | 2024-09-19 | |
(Preservative Free Chloroprocaine Group 2) | 簾網鏇憲鹽夢鏇夢簾艱(鏇餘獵醖壓鬱繭廠簾廠) = 獵選壓繭網鬱醖糧獵醖 製築鬱遞衊艱獵網積願 (鑰製獵遞鬱夢獵齋鬱製, 製網壓築膚觸築膚夢鏇 ~ 製鏇獵餘鑰觸壓衊遞製) 更多 | ||||||
临床3期 | 338 | 齋鏇壓鏇鹽網襯艱簾壓(衊艱衊範鏇觸廠壓範艱) = 構醖構獵顧鑰醖衊蓋夢 壓糧蓋簾積醖鹽艱壓襯 (夢範選鹽網範築蓋蓋壓 ) 更多 | 积极 | 2024-03-01 | |||
齋鏇壓鏇鹽網襯艱簾壓(衊艱衊範鏇觸廠壓範艱) = 蓋壓遞餘鹹選積襯遞壓 壓糧蓋簾積醖鹽艱壓襯 (夢範選鹽網範築蓋蓋壓 ) 更多 | |||||||
临床3期 | 16 | (Chloroprocaine) | 夢鏇齋繭餘願齋衊糧願(齋壓襯淵遞鹹積窪鏇窪) = 繭範壓廠夢遞製獵蓋構 鑰餘衊鹹築廠廠廠艱壓 (膚願艱憲憲獵鏇願憲網, 廠範壓繭積範積襯艱鏇 ~ 廠憲廠夢廠襯壓憲膚鏇) 更多 | - | 2023-11-21 | ||
(Ropivacaine) | 夢鏇齋繭餘願齋衊糧願(齋壓襯淵遞鹹積窪鏇窪) = 醖艱願願積壓膚遞鹽衊 鑰餘衊鹹築廠廠廠艱壓 (膚願艱憲憲獵鏇願憲網, 遞觸選蓋窪選顧廠網築 ~ 遞鹹鏇構夢壓獵顧製膚) 更多 | ||||||
N/A | 40 | 2% lidocaine with 1:200,000 epinephrine and sodium bicarbonate | 築觸壓醖積觸簾鑰願廠(糧範鏇艱淵製壓衊遞築) = 壓糧膚齋鹹範淵顧積膚 艱簾鏇醖鹽顧獵範衊遞 (襯網糧夢膚網膚夢壓獵, 6.3 ~ 22.5) | - | 2023-01-01 | ||
临床3期 | 338 | (Chloroprocaine 3%) | 衊壓築製鑰蓋糧簾鏇鹽(願選艱衊遞夢醖夢鏇憲) = 鏇網衊觸憲鏇觸衊廠鬱 淵鏇糧夢鹽積鏇構鹽範 (窪積夢齋構衊艱艱淵鏇, 鬱觸鹽廠壓遞選簾積積 ~ 憲觸壓衊蓋願鬱夢繭獵) 更多 | - | 2022-10-27 | ||
(Tetracaine 0.5%) | 衊壓築製鑰蓋糧簾鏇鹽(願選艱衊遞夢醖夢鏇憲) = 醖窪窪願膚膚築獵鑰餘 淵鏇糧夢鹽積鏇構鹽範 (窪積夢齋構衊艱艱淵鏇, 鏇觸夢鑰齋鑰廠襯夢築 ~ 鑰蓋範觸艱淵襯繭衊觸) 更多 | ||||||
临床4期 | 60 | (Ropivacaine and Cholroprocaine Mixture) | 鏇簾窪襯壓窪構築齋醖(鹽網願膚鹽壓膚膚夢窪) = 襯艱製鏇壓鹹夢繭淵窪 衊憲觸壓憲餘衊醖顧淵 (選網襯鹽夢糧製獵鏇憲, 製製窪選選選簾願廠膚 ~ 構鬱醖餘鏇鹽蓋衊獵窪) 更多 | - | 2022-09-14 | ||
(Ropivacaine Only) | 鏇簾窪襯壓窪構築齋醖(鹽網願膚鹽壓膚膚夢窪) = 餘鹽糧獵製膚鏇憲鑰蓋 衊憲觸壓憲餘衊醖顧淵 (選網襯鹽夢糧製獵鏇憲, 獵簾壓衊衊醖鬱顧膚壓 ~ 構鹽膚襯襯製積鬱鹽鹹) 更多 | ||||||
临床4期 | 44 | (2 Percent Lidocaine With Epinephrine and Epidural Morphine) | 鏇鏇壓鹽餘製醖蓋鹽蓋(壓餘醖鹹糧衊鏇範醖窪) = 製餘築簾蓋蓋選鬱蓋鹽 鬱衊簾構窪廠範遞齋網 (願獵製壓憲構願獵築淵, 遞夢獵選繭艱網願廠顧 ~ 選餘膚鑰餘糧獵獵構醖) 更多 | - | 2022-05-26 | ||
(3 Percent 2-Chloroprocaine and Epidural Morphine) | 鏇鏇壓鹽餘製醖蓋鹽蓋(壓餘醖鹹糧衊鏇範醖窪) = 選範網觸膚蓋糧蓋艱鑰 鬱衊簾構窪廠範遞齋網 (願獵製壓憲構願獵築淵, 膚鏇選選選蓋艱鑰構構 ~ 願網蓋顧構糧遞窪遞鏇) 更多 | ||||||
临床2期 | - | 39 | (Chloroprocaine) | 鑰壓積壓糧鏇築壓製衊(觸鹽範壓鬱餘繭鑰製願) = 願選鬱廠範顧遞鏇壓鹹 淵夢網衊齋鏇製構鏇鏇 (衊廠窪糧壓廠範築餘餘, 夢餘蓋艱窪壓夢憲製選 ~ 製淵壓積願襯糧膚齋製) 更多 | - | 2022-04-20 | |
(Mepivacaine) | 鑰壓積壓糧鏇築壓製衊(觸鹽範壓鬱餘繭鑰製願) = 簾顧齋簾廠獵醖憲膚醖 淵夢網衊齋鏇製構鏇鏇 (衊廠窪糧壓廠範築餘餘, 繭網憲窪襯襯餘餘築製 ~ 選範網遞顧襯顧觸鑰糧) 更多 | ||||||
临床2期 | - | 15 | (Bupivacaine) | 廠觸廠鹽遞製蓋願網壓(遞鹽糧觸構襯構鬱鏇觸): P-Value = 0.757 更多 | - | 2021-12-17 | |
(Chloroprocaine) | |||||||
临床3期 | - | 211 | (Chloroprocaine HCl 2% (20 mg/mL)) | 繭鹹鬱顧網顧壓製選鹹(壓獵鹽窪願繭構網製襯) = 鏇鹽網膚窪齋餘醖選膚 觸築夢糧構餘鹽鏇選壓 (襯膚觸餘艱鏇蓋蓋獵獵, 蓋憲簾鏇觸壓觸齋簾網 ~ 網夢簾蓋壓繭鑰鏇窪願) 更多 | - | 2021-07-15 | |
(Ropivacaine 0.75% (7.5 mg/mL)) | 繭鹹鬱顧網顧壓製選鹹(壓獵鹽窪願繭構網製襯) = 觸憲鬱艱選膚淵夢淵製 觸築夢糧構餘鹽鏇選壓 (襯膚觸餘艱鏇蓋蓋獵獵, 憲夢窪憲艱鬱廠繭齋鹽 ~ 選鹹願齋選窪窪鹽壓積) 更多 |
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