Streptozocin

*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放 截至01月03日15点59分，近期共有 236 本期刊发布了 621 篇文章，其中糖尿病相关的文章共 222 篇，覆盖 28 个领域的内容。中国专家参与发表的文章有 56 篇。今日，影响因子最高的文章刊登在 British Medical Journal (IF: 105.700) 期刊上。 今日头条 Headlines 01 Nature medicine IF: 50.000 共患病的共同与特异性血液生物标志物 Ornago, Alice Margherita, Gregorio, Caterina, Triolo, Federico, Moore, Ann Zenobia, Marengoni, Alessandra, Beridze, Giorgi, etc. 近日，一项发表于《Nature medicine》的研究，通过对大规模老年人群队列的长期追踪与血液分析，揭示了与多种慢性疾病同时发生（即共患病或多病共存）密切相关的关键血液生物标志物。该研究不仅发现了对多种疾病模式具有普遍预测价值的“共同”标志物，还识别了与特定疾病组合相关的“特异性”标志物，为理解老龄化进程中疾病累积的复杂生物学机制提供了新见解。 研究由Alice Margherita Ornago、Caterina Gregorio、Federico Triolo等多位学者合作完成。团队分析了来自瑞典国家老化与护理研究Kungsholmen的2，247名60岁及以上参与者的数据。研究人员检测了参与者血液中54种生物标志物，这些标志物覆盖了炎症、血管功能、代谢及神经退行性变等多个关键生物学过程。 为了全面刻画多病共存，研究采用了三种衡量方式：参与者基线时患有的慢性疾病总数；通过潜在类别分析识别出的、具有相似疾病组合的基线多病模式（例如以心血管和代谢疾病为主的模式）；以及长达15年随访期间新发疾病的积累速度。利用先进的统计模型，研究团队系统评估了基线生物标志物水平与这些多病指标之间的关联。 分析结果揭示了一组核心的生物标志物。具体而言，生长分化因子15、糖化血红蛋白、胱抑素C、瘦素和胰岛素这五种标志物的水平升高，与参与者基线时更高的疾病负担、特定的多病模式以及未来15年内更快的疾病积累速度均存在显著的正向关联。这表明，这些反映细胞应激、糖代谢、肾功能和脂肪代谢等过程的指标，可能是驱动多病共存的“共同通路”。 与此同时，研究还发现了其他一些生物标志物，它们与特定的多病模式存在更强的关联，提示了不同疾病组合背后可能存在独特的生物学路径。此外，在纵向分析中，基线时较高的γ-谷氨酰转移酶水平和较低的血清白蛋白水平，被证明能够独立预测未来更快的疾病积累过程。 为确保研究发现的可信度，研究团队在另一个独立的老年队列——美国巴尔的摩老龄化纵向研究的522名参与者中进行了外部验证。验证结果显示，上述关键生物标志物在预测疾病积累方面具有可比性的准确性，增强了研究结论的普适性。 综合这些发现，研究指出，衰老过程中多病共存的产生并非源于单一的生物学异常，而是多种生理过程失调共同作用的结果，其中既存在跨越不同疾病类型的共享机制，也存在针对特定疾病组合的特异性机制。尤为重要的是，代谢系统的功能紊乱在所有这些关联中占据了核心地位，提示它可能是干预和延缓老年疾病累积的一个关键切入点。这项研究为未来开发针对多病共存的早期预警工具和预防性干预策略奠定了重要的科学基础。 本文由 天纳乾坤 编辑 扫描二维码查看源文 Nature medicine | Ahead of Print. 10.1038/s41591-025-04038-2 02 Nature medicine IF: 50.000 GLP-1药物的广阔前景 Drucker, Daniel J 近日，《自然医学》期刊发表了一篇关于胰高血糖素样肽-1（GLP-1）类药物的综述文章，总结了这类药物当前的应用版图与未来的发展方向。文章指出，以司美格鲁肽、替尔泊肽等为代表的GLP-1类药物，正在全球范围内改变2型糖尿病和肥胖症的临床管理实践，并显著影响着相关的公共卫生策略。 这类药物的影响力已超越传统的降糖与减重领域。大量临床证据表明，它们能够有效降低2型糖尿病和肥胖患者的主要心血管不良事件风险，并已被批准用于降低伴有心血管疾病或多种心血管风险因素患者的心血管事件。此外，其适应症正进一步扩展至外周动脉疾病和阻塞性睡眠呼吸暂停等与代谢密切相关的并发症。 药物研发的步伐正在加快。新一代的GLP-1类药物通过优化分子结构和药代动力学特性，展现了比现有药物更强的减重效能。更令人期待的是，研究人员正在开发“多靶点”分子，例如将GLP-1与胰高血糖素、葡萄糖依赖性促胰岛素多肽等其他肽类激素的功能域相结合。这些新药可能通过多通路协同作用，在控制体重和血糖之外，对脂肪肝、血脂异常等多种代谢紊乱产生更广泛的益处。 GLP-1类药物发挥效益的机制也日益清晰。除了众所周知的通过中枢神经系统抑制食欲、延缓胃排空以降低血糖和体重外，研究发现它们还具有直接的抗炎作用，并能激活心、肾、血管等外周器官的受体，这为解释其心血管和肾脏保护作用提供了新视角。 基于其多效性，科学界正积极探索GLP-1类药物在更广泛疾病领域的应用潜力。目前正在进行的临床前与临床研究，正评估其在神经退行性疾病（如阿尔茨海默病、帕金森病）、物质使用障碍（如酒精成瘾）、代谢相关性脂肪肝病、骨关节炎、甚至1型糖尿病和炎症性肠病中的治疗可能性。这些探索可能在未来数年进一步拓宽此类药物的治疗疆域。 随着适应症的不断扩展和使用人群的急剧增长，对这类药物长期安全性的监测与评估也至关重要。文章同时指出，尽管前景广阔，但不同新分子在具体疾病中的疗效差异、最佳适用人群以及长期使用的未知影响，仍是需要持续研究的关键问题。 本文由 天纳乾坤 编辑 扫描二维码查看源文 Nature medicine | Ahead of Print. 10.1038/s41591-025-04124-5 03 Nature medicine IF: 50.000 通过脂肪组织-微生物组相互作用多组学定义代谢性肥胖 Chakaroun, Rima M, Pradhan, Meenakshi, Björnson, Elias, Arvidsson, Daniel, Fridolfsson, Jonatan, Gummesson, Anders, etc. 近日，一项发表于《自然-医学》（Nature medicine）的研究为理解肥胖的复杂性带来了新视角。由Rima M Chakaroun、Fredrik Bäckhed等学者领导的国际团队，通过大规模多组学分析，定义了一种超越传统身体质量指数（BMI）的新型代谢指标，揭示了脂肪组织功能障碍、全身代谢状态与肠道微生物组之间深刻而双向的对话。 该研究始于一个临床共识：同样高的BMI，个人的代谢健康状态却可能天差地别。为了捕捉这种异质性，研究者对1,408名个体进行了深入的血液代谢组等多组学分析，从中提炼出一个名为“代谢BMI”（metBMI）的新指标。这个指标的核心在于反映与脂肪组织功能障碍相关的全身代谢失调。 为了验证其效力，研究团队在一个独立的466人外部队列中进行了测试。结果显示，metBMI能够解释传统BMI高达52%的变异，并且在预测个体实际脂肪量方面，表现优于其他基于组学的模型。这标志着metBMI并非BMI的简单替代，而是一个能更精确反映“代谢性肥胖”状态的生物学标尺。 更重要的是，metBMI与临床结局紧密相连。研究发现，那些metBMI高于其传统BMI预期水平的人群，面临着显著升高的健康风险：他们罹患非酒精性脂肪肝病、2型糖尿病、出现严重内脏脂肪堆积或脂肪衰减、胰岛素抵抗、高胰岛素血症以及全身炎症状态的风险，比预期高出2至5倍。甚至在干预层面，一项针对75名接受减重手术患者的研究显示，高metBMI的个体术后体重减轻效果比预期平均减少30%。这些发现强烈提示，metBMI是一个强有力的心脏代谢风险分层工具。 研究的另一大亮点在于将代谢特征与肠道微生物组联系起来。这种由metBMI定义的致肥胖代谢特征，与肠道微生物组的多样性降低、菌群生态结构改变及其功能潜力变化显著相关。为了将复杂的科学发现推向潜在临床应用，研究者进一步鉴定出一个由66个血液代谢物组成的简化组合。这个精简组合仍能保留metBMI约38.6%的解释力，并且其中高达90%的代谢物水平与肠道微生物组的构成变化同步波动。 通过先进的统计分析，研究最终描绘出一个核心机制图景：在宿主与肠道微生物之间，存在一个双向的、以特定代谢物为交流媒介的“对话”轴。脂质、氨基酸以及由饮食经微生物代谢产生的化合物（如短链脂肪酸等）在其中扮演了关键信使的角色。这一轴线的失衡，可能驱动或加剧了与脂肪组织相关的全身代谢紊乱。 综上所述，这项研究通过多组学深度解析，定义了一个紧密关联脂肪组织健康、且与肠道微生物组功能交互的代谢特征谱。其所提出的metBMI及相关的代谢物标志物，为在临床实践中更精细地区分不同代谢类型的肥胖个体提供了新工具，也为未来开发针对微生物-宿主代谢轴的新型精准预防与治疗策略奠定了科学基础。 本文由 天纳乾坤 编辑 扫描二维码查看源文 Nature medicine | Ahead of Print. 10.1038/s41591-025-04009-7 中国发表（56） China Int J Biol Macromol IF: 08.500Ahead of Print.No.01Preparation methods, structural characteristics, bioactivities, and structure-activity relationships of polysaccharides from Moutan Cortex: A review牡丹皮多糖的制备方法、结构特征、生物活性及构效关系研究进展DOI: 10.1016/j.ijbiomac.2025.149999 Journal of controlled release IF: 11.500Ahead of Print.No.02Glucose-responsive cascade nanozyme for controlled ROS release and bacterial carbon metabolic reprogramming in infected diabetic wounds用于感染性糖尿病伤口的葡萄糖响应级联纳米酶实现活性氧可控释放与细菌碳代谢重编程DOI: 10.1016/j.jconrel.2025.114590 Journal of ethnopharmacology IF: 05.400Ahead of Print.No.03Mechanism of Astragali radix Combined with Salviae miltiorrhizae Radix et Rhizoma in Alleviating Diabetic Nephropathy: Focus on the AGEs/RAGE/MAPK Signaling Pathway黄芪与丹参配伍改善糖尿病肾病的作用机制：聚焦于AGEs/RAGE/MAPK信号通路DOI: 10.1016/j.jep.2025.121131 Nature metabolism IF: 20.800Ahead of Print.No.04Single-cell perturbations decipher ribosomal stress-surveillance regulators in type 2 diabetes单细胞扰动技术解析2型糖尿病中的核糖体应激监视调节因子DOI: 10.1038/s42255-025-01407-6 Proc Natl Acad Sci U S A IF: 09.100Volume 123, Issue 1No.05L-lactic acid enhances type I interferon immune response and inhibits virus infection by promoting IRF9 L-lactylationL-乳酸通过促进IRF9 L-乳酸化增强I型干扰素免疫反应并抑制病毒感染DOI: 10.1073/pnas.2521070123 PloS one IF: 02.600Volume 21, Issue 1No.06Association of atherogenic index of plasma and triglyceride-glucose index with atrial fibrillation: A retrospective study血浆致动脉粥样硬化指数与甘油三酯-葡萄糖指数和心房颤动的关联：一项回顾性研究DOI: 10.1371/journal.pone.0338958 PloS one IF: 02.600Volume 21, Issue 1No.07A non-invasive urinary diagnostic signature for diabetic kidney disease revealed by machine learning and single-cell analysis基于机器学习和单细胞分析揭示的糖尿病肾病非侵入性尿液诊断标志物DOI: 10.1371/journal.pone.0340096 Natural product research IF: 01.600Ahead of Print.No.08Research progress on triterpenoids in the genus Rubus: a comprehensive review悬钩子属三萜类化合物研究进展：全面综述DOI: 10.1080/14786419.2025.2608702 Journal of natural products IF: 03.600Ahead of Print.No.09Discovery, α-Glucosidase Inhibitory Activity, and Structural Optimization of the Alkaloids from Vanderbylia robiniophila SY636从药用真菌 Vanderbylia robiniophila SY636 中发现具有 α-葡萄糖苷酶抑制活性的生物碱并进行结构优化DOI: 10.1021/acs.jnatprod.5c01304 World journal of clinical cases IF: 01.000Volume 13, Issue 36No.10Influence of obesity on the patient's recovery after laparoscopic surgery肥胖对腹腔镜手术后患者恢复的影响DOI: 10.12998/wjcc.v13.i36.115269 Int J Endocrinol IF: 02.300Volume 2025, Issue No.11Decoding the Nonlinear Association Between Visceral Adiposity Index and All-Cause Mortality: The Mediating Role of White Blood Cells and Neutrophils解码内脏脂肪指数与全因死亡率的非线性关联：白细胞与中性粒细胞的中介作用DOI: 10.1155/ije/3116986 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.12Obstructive sleep apnea is associated with greater MASH and significant fibrosis severity in patients with obesity: A prospective clinicopathological study阻塞性睡眠呼吸暂停与肥胖患者更严重的代谢功能障碍相关脂肪性肝炎和显著纤维化相关：一项前瞻性临床病理学研究DOI: 10.1111/dom.70383 Journal of medicinal chemistry IF: 06.800Ahead of Print.No.13High-Throughput Screening of Natural Products Alleviating Diabetic Nephropathy Using a Peroxynitrite (ONOO(-)) Responsive Fluorescent Probe利用过氧亚硝酸盐响应型荧光探针对缓解糖尿病肾病的天然产物进行高通量筛选DOI: 10.1021/acs.jmedchem.5c03228 Int J Mol Med IF: 05.800Volume 57, Issue 3No.14Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)铁死亡在认知障碍中的作用与机制：从分子通路到治疗靶点DOI: 10.3892/ijmm.2025.5725 Int J Mol Med IF: 05.800Volume 57, Issue 3No.15The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)GPR124‑Wnt‑PPARγ调控轴：在慢性炎症性疾病中的分子机制与治疗意义（综述）DOI: 10.3892/ijmm.2025.5724 World journal of diabetes IF: 04.600Volume 16, Issue 12No.16Long-term and short-term exposure to outdoor air pollution and its association with glycolipid metabolic disorders长期与短期暴露于室外空气污染及其与糖脂代谢紊乱的关联研究DOI: 10.4239/wjd.v16.i12.110028 World journal of diabetes IF: 04.600Volume 16, Issue 12No.17Methylation status of leptin gene promoter in relatively lean Chinese adults with prediabetes and type 2 diabetes mellitus相对消瘦的中国成人糖尿病前期和2型糖尿病患者的瘦素基因启动子甲基化状态DOI: 10.4239/wjd.v16.i12.112789 World journal of diabetes IF: 04.600Volume 16, Issue 12No.18Identification of novel therapeutic targets for diabetic neuropathy through integrated proteomics and transcriptomics approaches通过整合蛋白质组学与转录组学方法识别糖尿病神经病变的新型治疗靶点DOI: 10.4239/wjd.v16.i12.111963 World journal of diabetes IF: 04.600Volume 16, Issue 12No.19Zhejiang University index predicts metabolic dysfunction-associated steatotic liver disease in type 2 diabetes mellitus patients浙江大学指数预测2型糖尿病患者发生代谢功能障碍相关脂肪性肝病DOI: 10.4239/wjd.v16.i12.114565 World journal of diabetes IF: 04.600Volume 16, Issue 12No.20Effect of fish scale ointment on diabetic foot ulcer by inducing ferroptosis via the nuclear factor E2-related factor 2 pathway鱼鳞膏通过核因子E2相关因子2通路诱导铁死亡对糖尿病足溃疡的作用DOI: 10.4239/wjd.v16.i12.111789 Patient preference and adherence IF: 02.000Volume 19, Issue No.21A Mediation Model of Medication Literacy and Adherence in Type 2 Diabetes During Hospital-Home Transition医院-家庭过渡期2型糖尿病患者用药素养与服药依从性的中介作用模型研究DOI: 10.2147/PPA.S556814 Frontiers in medicine IF: 03.000Volume 12, Issue No.22A machine learning-based predictive model for stem cell therapy outcomes in plastic surgery基于机器学习的整形外科干细胞治疗结局预测模型DOI: 10.3389/fmed.2025.1683758 FCVM IF: 02.900Volume 12, Issue No.23Mechanism and treatment of Sirtuin family in vascular calcificationSirtuin家族在血管钙化中的作用机制与治疗展望DOI: 10.3389/fcvm.2025.1732281 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.24Configurational paths to promoting physical activity among older adults with type 2 diabetes in China: an fsQCA study based on the multi-theory model促进中国老年2型糖尿病患者体力活动的组态路径：一项基于多理论模型的fsQCA研究DOI: 10.3389/fendo.2025.1673625 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.25Correction: Comparative analysis of the therapeutic effect of antibiotic bone cement on Wagner grade 3 or 4 diabetic foot ulcer in heel and non-heel areas: a retrospective cohort studyWagner 3级或4级糖尿病足溃疡在足跟区与非足跟区应用抗生素骨水泥疗效比较分析的修正：一项回顾性队列研究DOI: 10.3389/fendo.2025.1762804 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.26Inulin and Lycium barbarum polysaccharides mitigate the diabetic inflammatory response by modulating bile acid metabolism to enhance regulatory T cell (Treg) activation in a rat model of diabetes菊粉与枸杞多糖通过调节胆汁酸代谢增强调节性T细胞活化，从而减轻糖尿病大鼠的炎症反应DOI: 10.3389/fendo.2025.1705635 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.27Efficacy and safety of sacubitril/valsartan combined with dapagliflozin in non-diabetic patients with advanced chronic kidney disease沙库巴曲缬沙坦联合达格列净在非糖尿病晚期慢性肾脏病患者中的有效性和安全性DOI: 10.3389/fendo.2025.1681260 Front Mol Biosci IF: 04.000Volume 12, Issue No.28Asparagine-related biomarkers and regulatory mechanisms in type 2 diabetes mellitus天冬酰胺相关生物标志物及其在2型糖尿病中的调控机制DOI: 10.3389/fmolb.2025.1733878 Frontiers in microbiology IF: 04.500Volume 16, Issue No.29Bile acid-microbiota interactions in cardiometabolic diseases: mechanisms and emerging therapeutic approaches胆汁酸-微生物群相互作用在心脏代谢疾病中的机制及新兴治疗方法DOI: 10.3389/fmicb.2025.1689026 World journal of nephrologyVolume 14, Issue 4No.30Gut microbiota-derived trimethylamine N-oxide exacerbates diabetic nephropathy by promoting renal fibrosis肠道菌群代谢物氧化三甲胺通过促进肾脏纤维化加剧糖尿病肾病DOI: 10.5527/wjn.v14.i4.112066 World J Gastroenterol IF: 05.400Volume 31, Issue 47No.31Feasibility and safety of enhanced recovery after surgery in elderly patients with gastric cancer加速康复外科在老年胃癌患者中的可行性与安全性研究DOI: 10.3748/wjg.v31.i47.113331 World J Gastroenterol IF: 05.400Volume 31, Issue 47No.32Artificial intelligence applications for managing metabolic dysfunction-associated steatotic liver disease: Current status and future prospects人工智能应用管理代谢功能障碍相关脂肪性肝病：现状与未来展望DOI: 10.3748/wjg.v31.i47.111900 Frontiers in neurology IF: 02.800Volume 16, Issue No.33Admission monocyte-to-albumin ratio predicts 3-month functional outcomes after acute ischemic stroke: a retrospective cohort study入院单核细胞-白蛋白比值预测急性缺血性卒中患者3个月功能结局：一项回顾性队列研究DOI: 10.3389/fneur.2025.1705544 Front Cell Infect Microbiol IF: 04.800Volume 15, Issue No.34The impact of diabetes mellitus on biomarkers for the diagnosis of periprosthetic joint infection糖尿病对假体周围感染诊断生物标志物的影响DOI: 10.3389/fcimb.2025.1720431 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.35Association between free triiodothyronine and diabetic retinopathy: insights from a longitudinal cohort study and Mendelian randomization游离三碘甲状腺原氨酸与糖尿病视网膜病变的关联：一项纵向队列研究和孟德尔随机化的启示DOI: 10.3389/fendo.2025.1677122 World J Gastroenterol IF: 05.400Volume 31, Issue 48No.36Serum uric acid-to-high-density lipoprotein cholesterol ratio and cardiovascular risk in Asian patients with metabolic dysfunction-associated steatotic liver disease亚洲代谢功能障碍相关脂肪性肝病患者血清尿酸与高密度脂蛋白胆固醇比值和心血管风险DOI: 10.3748/wjg.v31.i48.112972 World journal of hepatology IF: 02.500Volume 17, Issue 12No.37Integrated serum metabolomics reveal molecular mechanism of Xietu Hemu prescription on metabolic dysfunction-associated steatotic liver disease-related obesity整合血清代谢组学揭示泄浊和木方对代谢功能障碍相关脂肪性肝病相关肥胖的分子机制DOI: 10.4254/wjh.v17.i12.113660 World J Gastroenterol IF: 05.400Volume 31, Issue 46No.38Epidemiology of metabolic dysfunction-associated steatotic liver disease/metabolic dysfunction-associated steatohepatitis and associated cardiometabolic factors in adults in China (2013-2023): A systematic review and meta-analysis中国成人代谢功能障碍相关脂肪性肝病/代谢功能障碍相关脂肪性肝炎的流行病学及其相关心脏代谢因素（2013-2023）：一项系统评价与荟萃分析DOI: 10.3748/wjg.v31.i46.113608 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.39Levothyroxine dose prediction post-thyroidectomy for differentiated thyroid carcinoma分化型甲状腺癌甲状腺全切术后左甲状腺素剂量预测DOI: 10.3389/fendo.2025.1727681 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.40Construction and evaluation of STZ-induced diabetes and diabetic kidney disease models in C57BL/6J mice在C57BL/6J小鼠中构建与评估STZ诱导的糖尿病及糖尿病肾病模型DOI: 10.3389/fendo.2025.1711035 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.41Specificity of endothelial cells in endothelial dysfunction of diabetic kidney disease and their crosstalk with neighboring cells: an updated review糖尿病肾病内皮功能障碍中内皮细胞的特异性及其与邻近细胞的交流：一篇更新综述DOI: 10.3389/fendo.2025.1742296 Frontiers in immunology IF: 05.900Volume 16, Issue No.42Integrated bioinformatics and machine learning reveal pan-apoptosis and immune infiltration signatures in diabetic nephropathy整合生物信息学与机器学习揭示糖尿病肾病中的泛凋亡及免疫浸润特征DOI: 10.3389/fimmu.2025.1659065 Cardiology in the Young IF: 00.900Ahead of Print.No.43Ventricular arrhythmia and Noonan syndrome with leucine zipperlike transcription regulator 1 mutations: expanding the phenotype with a case report and review of the literature室性心律失常与亮氨酸拉链样转录调节因子1基因突变相关的努南综合征：通过病例报告和文献综述扩展表型谱DOI: 10.1017/S1047951125110330 World journal of diabetes IF: 04.600Volume 16, Issue 12No.44Liraglutide alleviates diabetic cardiomyopathy in streptozotocin-induced diabetic rats by enhancing mitophagy mediated by the AMPK-Parkin signaling pathway利拉鲁肽通过增强AMPK-Parkin信号通路介导的线粒体自噬减轻链脲佐菌素诱导的糖尿病大鼠的糖尿病心肌病DOI: 10.4239/wjd.v16.i12.112423 World journal of diabetes IF: 04.600Volume 16, Issue 12No.45Oral Akkermansia muciniphila may ameliorates immune dysregulation in a murine model of streptozotocin-induced type 1 diabetes口服Akkermansia muciniphila可能改善链脲佐菌素诱导的1型糖尿病小鼠模型的免疫失调DOI: 10.4239/wjd.v16.i12.111771 World journal of diabetes IF: 04.600Volume 16, Issue 12No.46Clinical and genetic characteristics of young-onset diabetes with concurrent mitochondrial m.3243A>G and CEL gene mutations: A case report青年起病型糖尿病并发线粒体m.3243A>G与CEL基因突变的临床与遗传学特征：一例病例报告DOI: 10.4239/wjd.v16.i12.113238 World journal of diabetes IF: 04.600Volume 16, Issue 12No.47Electroacupuncture in glycemic control: Transitioning from clinical controversies to potential basic research电针控糖：从临床争议到基础研究的潜力转化DOI: 10.4239/wjd.v16.i12.112580 World journal of diabetes IF: 04.600Volume 16, Issue 12No.48From fatty liver indices to the Zhejiang University index: Re-shaping risk stratification of metabolic liver disease in diabetes从脂肪肝指数到浙江大学指数：重塑糖尿病代谢性肝病的风险分层DOI: 10.4239/wjd.v16.i12.115435 World journal of diabetes IF: 04.600Volume 16, Issue 12No.49Immune activation induced by dysregulated lipid metabolism in the pathogenesis of type 2 diabetes免疫代谢耦合：2型糖尿病发病新机制DOI: 10.4239/wjd.v16.i12.114395 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.50Mitochondrial bioenergetics dysfunction in T2DM: linking oxidative stress to insulin resistance2型糖尿病中线粒体生物能量功能障碍：连接氧化应激与胰岛素抵抗DOI: 10.3389/fendo.2025.1674477 World J Gastrointest Oncol IF: 02.500Volume 17, Issue 12No.51Prognostic significance of preoperative C-reactive protein-triglyceride-glucose index in long-term outcomes after radical gastrectomy for gastric cancer术前C反应蛋白-甘油三酯-葡萄糖指数对胃癌根治术后长期预后的意义DOI: 10.4251/wjgo.v17.i12.113976 World J Clin Oncol IF: 03.200Volume 16, Issue 12No.52Metabolic syndrome and colorectal cancer: Mechanisms, epidemiological evidence, and clinical implications代谢综合征与结直肠癌：机制、流行病学证据及临床意义DOI: 10.5306/wjco.v16.i12.112639 Hepatic medicine IF: 01.800Volume 17, Issue No.53Literature Review on the Regulatory Effects of Hydrogen Sulfide in Non-Alcoholic Fatty Liver Disease (NAFLD)硫化氢在非酒精性脂肪性肝病中的调控作用研究综述DOI: 10.2147/HMER.S574921 World J Gastroenterol IF: 05.400Volume 31, Issue 47No.54Tumor necrosis factor-α promotes abnormal glucose metabolism after acute pancreatitis by inducing islet β-cell apoptosis via Bax/Bcl-2/caspase-3 signaling pathway肿瘤坏死因子-α经由Bax/Bcl-2/Caspase-3信号通路诱导胰岛β细胞凋亡从而促使急性胰腺炎后血糖异常DOI: 10.3748/wjg.v31.i47.113205 Drug Des Devel Ther IF: 05.100Volume 19, Issue No.55Xenin-Derived Peptides: Multifaceted Regulators and Therapeutic Innovations in Metabolic Diseases肠抑胃肽衍生肽：代谢疾病中的多面调控者与治疗新策略DOI: 10.2147/DDDT.S565077 Am J Case Rep IF: 01.000Volume 27, Issue No.56Multidisciplinary Management and Anesthesia Considerations for Diabetic Ketoacidosis With Hypertriglyceridemic Acute Pancreatitis in Pregnancy: A Case Report妊娠期糖尿病酮症酸中毒合并高甘油三酯血症性急性胰腺炎的多学科管理与麻醉考量：病例报告DOI: 10.12659/AJCR.949837 其他发布内容（163） More Published Articles J Stroke Cerebrovasc Dis IF: 01.800Ahead of Print.No.01Association between cumulative changes of the triglyceride glucose index and incidence of Cardio-cerebral vascular diseases in a population with cardiovascular-kidney-metabolic syndrome stage 0–3: a nationwide prospective cohort study累积甘油三酯-葡萄糖指数变化与心血管-肾脏-代谢综合征0-3期人群心脑血管疾病发病率的关联：一项全国性前瞻性队列研究DOI: 10.1016/j.jstrokecerebrovasdis.2026.108540 Cleve Clin J Med IF: 04.100Volume 93, Issue 1No.02A young woman with Kallmann syndrome and acute neurologic symptoms一例Kallmann综合征合并急性神经系统症状的年轻女性DOI: 10.3949/ccjm.93a.25010 Immunology letters IF: 02.800Ahead of Print.No.03LCK at the Crossroad of Immunodeficiency and Autoimmunity: Mechanisms and Therapeutic OpportunitiesLCK在免疫缺陷与自身免疫的十字路口：机制与治疗机遇DOI: 10.1016/j.imlet.2025.107126 Complement Ther Med IF: 03.500Ahead of Print.No.04The health effects of diaphragmatic breathing: a systematic review膈肌呼吸的健康效应：一项系统综述DOI: 10.1016/j.ctim.2025.103317 Experimental neurology IF: 04.200Ahead of Print.No.05Demethyleneberberine attenuates combined cognitive and metabolic dysfunctions in an insulin-resistance-induced Alzheimer's disease rat model: Synthesis, in-silico and in-vivo insights去甲基小檗碱改善胰岛素抵抗诱导的阿尔茨海默病大鼠模型的认知与代谢联合功能障碍：合成、计算机模拟与体内研究DOI: 10.1016/j.expneurol.2025.115634 Canadian journal of diabetes IF: 02.600Ahead of Print.No.06DIABETES RISK IS INCREASED IN FIRST NATIONS AND NON-FIRST NATIONS OFFSPRING OF DIABETIC MOTHERS AND WORSENED FOR THOSE LARGE FOR GESTATIONAL AGE: Results from the DIP: ORRIIGENSS Project原住民与非原住民后代的糖尿病风险在糖尿病母亲所生后代中均升高，并于大于胎龄儿中进一步加剧：来自DIP: ORRIIGENSS项目的结果DOI: 10.1016/j.jcjd.2025.12.012 J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.07Approach to the Patient Considering Thyroid Hormone Deprescribing针对考虑甲状腺激素减药患者的处理方法DOI: 10.1210/clinem/dgaf697 In vivo IF: 01.800Volume 40, Issue 1No.08The Impact of Metabolic Comorbidities (Diabetes, Hypertension) on the Severity and Progression of Oropharyngeal Infections代谢合并症（糖尿病、高血压）对口咽感染严重程度及进展的影响DOI: 10.21873/invivo.14228 Endocrine practice IF: 04.600Ahead of Print.No.09Adolescents with type 1 diabetes using dapagliflozin as an adjunct-to-insulin: Perspectives on experiences of clinical trial participation青少年1型糖尿病患者使用达格列净作为胰岛素辅助治疗的视角：基于临床试验参与经历的探讨DOI: 10.1016/j.eprac.2025.12.019 Journal of dairy science IF: 04.400Ahead of Print.No.10Associations of individual nutrient and non-nutrient factors on endocrine and metabolic parameters in neonatal calves fed colostrum from their own dams饲喂自身母牛初乳的新生犊牛：单一营养素与非营养素因素对其内分泌与代谢参数的相关性研究DOI: 10.3168/jds.2025-27341 In vivo IF: 01.800Volume 40, Issue 1No.11Anti-inflammatory Pathways of Novel Anti-diabetic Therapies. A Literature Review新型抗糖尿病疗法的抗炎途径：一篇文献综述DOI: 10.21873/invivo.14224 Gut : IF: 25.800Ahead of Print.No.12Simvastatin in the prevention of recurrent pancreatitis: a triple-blinded randomised clinical trial (the SIMBA trial)辛伐他汀预防复发性胰腺炎：一项三盲随机临床试验（SIMBA试验）DOI: 10.1136/gutjnl-2025-337154 In vivo IF: 01.800Volume 40, Issue 1No.13Sodium-Glucose Cotransporter 2 Inhibitors and Reduced Fibromyalgia Risk in Patients With Diabetes: A Target Trial Emulation Study钠-葡萄糖协同转运蛋白2抑制剂与糖尿病患者纤维肌痛风险降低：一项靶向试验模拟研究DOI: 10.21873/invivo.14229 Nature Cardiovascular Research IF: 10.800Ahead of Print.No.14Loss of function of the obesity-associated gene MC4R reduces cardiovascular risk and increases lipid clearance肥胖相关基因MC4R功能丧失降低心血管风险并增加脂质清除DOI: 10.1038/s44161-025-00764-5 Cleve Clin J Med IF: 04.100Volume 93, Issue 1No.15Update on antiobesity pharmacotherapy in adults: Current and emerging options成人抗肥胖药物治疗的最新进展：现有及新兴选择DOI: 10.3949/ccjm.93a.24112 British Medical Journal IF: 105.700Volume 392, Issue No.16Pill version of obesity jab is approved in US, with UK decision pending肥胖注射剂口服版在美国获批，英国决定待定DOI: 10.1136/bmj.s2 In vivo IF: 01.800Volume 40, Issue 1No.17Dysregulation of ERAD and Stress Response Proteins by V493F FTO Over-expression: A Proteomic PerspectiveV493F FTO蛋白过度表达对ERAD和应激反应蛋白的调节失衡：一项蛋白质组学视角的研究DOI: 10.21873/invivo.14188 In vivo IF: 01.800Volume 40, Issue 1No.18Effects of a Sodium-Glucose Cotransporter 2 Inhibitor Dapagliflozin on Pancreas in Obese Diabetic Mice达格列净对肥胖糖尿病小鼠胰腺的影响DOI: 10.21873/invivo.14227 In vivo IF: 01.800Volume 40, Issue 1No.19Pterostilbene Attenuates High Fat Diet-induced Obesity and Hepatic Dysfunction in Rats: A Functional Evaluation Based on Taiwan's Health Food Assessment Criteria紫檀芪通过台湾健康食品评估标准验证能减轻高脂饮食诱导的大鼠肥胖和肝功能障碍DOI: 10.21873/invivo.14225 Preventive medicine IF: 03.200Ahead of Print.No.20Association between adolescent overweight and adult mortality risk: A systematic review青少年超重与成人死亡风险的关联：一项系统综述DOI: 10.1016/j.ypmed.2025.108492 Journal of nutrition IF: 03.800Ahead of Print.No.21JN-2025-1710R1 Maximizing the Value of Pre-clinical and Translational Animal Research Models Via Next Generation Standardized Reference Diets: A White Paper from the Laboratory Animal Nutrition Taskforce for an Education and Research Network (LANTERN)通过下一代标准化参考饮食最大化临床前和转化动物研究模型的价值：来自教育与研究网络实验室动物营养特别工作组（LANTERN）的白皮书DOI: 10.1016/j.tjnut.2025.101309 Journal of nutrition IF: 03.800Ahead of Print.No.22Invited: Longitudinal assessment of diets with varying carbohydrate-to-fat ratios and fiber supplementation on immunometabolic markers, liver function, and gut microbiome特邀文章：对含不同碳水化合物-脂肪比例及补充纤维的饮食进行纵向评估——关于免疫代谢标志物、肝功能及肠道微生物组的研究DOI: 10.1016/j.tjnut.2025.101285 The spine journal IF: 04.700Ahead of Print.No.23GLP-1 Receptor Agonist Use and Perioperative Outcomes After ACDF: A Propensity-Matched Cohort StudyGLP-1受体激动剂的使用与颈椎前路间盘切除融合术围术期结局：一项倾向性匹配的队列研究DOI: 10.1016/j.spinee.2025.12.019 Survey of ophthalmology IF: 05.900Ahead of Print.No.24Glucagon-like peptide-1 receptor agonists: What ophthalmologists need to know胰高血糖素样肽-1受体激动剂：眼科医生须知DOI: 10.1016/j.survophthal.2025.12.007 The Journal of arthroplasty IF: 03.800Ahead of Print.No.25Body Mass Index of 45 is a Safe Cut-Off for Cementless Total Knee Arthroplasty体质量指数45是无骨水泥全膝关节置换术的安全界限DOI: 10.1016/j.arth.2025.12.038 Environmental research IF: 07.700Ahead of Print.No.26Social-ecological correlates of children's outdoor playtime and their interaction with gender: a national longitudinal study儿童户外游戏时间的社会生态学相关因素及其与性别的交互作用：一项全国性纵向研究DOI: 10.1016/j.envres.2025.123625 Am J Clin Nutr IF: 06.900Ahead of Print.No.27Impact of maternal diet on microbiota and health during pregnancy: a systematic review and correlational meta-analysis孕期母亲饮食对微生物群与健康的影响：一项系统综述与相关荟萃分析DOI: 10.1016/j.ajcnut.2025.101175 Cleve Clin J Med IF: 04.100Volume 93, Issue 1No.28Atrial fibrillation in patients with obesity: How can we optimize management?肥胖患者的心房颤动：如何优化管理DOI: 10.3949/ccjm.93a.25032 In vivo IF: 01.800Volume 40, Issue 1No.29Anti-Inflammatory and Anti-apoptotic Effects of Phosphodiesterase Inhibitors Against Streptozocin-induced Diabetic Nephropathy磷酸二酯酶抑制剂对链脲佐菌素诱导的糖尿病肾病的抗炎及抗凋亡作用DOI: 10.21873/invivo.14226 In vivo IF: 01.800Volume 40, Issue 1No.30Hyperglycemia in Critically Ill Patients: Current Approaches and Management Strategies危重患者高血糖：当前方法与处理策略DOI: 10.21873/invivo.14223 ACS applied bio materials IF: 04.700Ahead of Print.No.31Synthesis of pH-Sensitive Nanocomposite Hydrogel Based on Poly(acrylic Acid) and Chitosan-Modified Multiwalled Carbon Nanotubes for Targeted and Controlled Release of Metformin基于聚丙烯酸和壳聚糖修饰多壁碳纳米管的pH敏感纳米复合水凝胶用于二甲双胍靶向控释的合成研究DOI: 10.1021/acsabm.5c01713 Diseases of the colon & rectum IF: 03.700Ahead of Print.No.32Surgical Approach Impacts Textbook Outcomes in Patients with Obesity Undergoing Colectomy for Right-Sided Colon Cancers手术方式影响肥胖患者右半结肠癌切除术的教科书结果DOI: 10.1097/DCR.0000000000004055 Blood transfusion IF: 02.300Ahead of Print.No.33Donor health beyond donation: cardiovascular risk factors in blood donor populations. A cross-sectional study献血者健康不止于献血：献血人群心血管危险因素的横断面研究DOI: 10.2450/BloodTransfus.1191 Kidney360 IF: 03.000Ahead of Print.No.34A Western Diet High in Phosphate Primes the Development of the CKD-Mineral Bone Disorder in an Alport Syndrome Model高磷西方饮食在Alport综合征模型中诱发慢性肾脏病-矿物质和骨异常DOI: 10.34067/KID.0000001065 Pain physician IF: 02.500Volume 28, Issue S7No.35Lumbar Medial Branch Radiofrequency Ablation: Technical Suggestions Based on Emerging Ex-Vivo Evidence腰椎内侧支射频消融：基于新兴离体证据的技术建议https://pubmed.ncbi.nlm.nih.gov/41481871 Curr Opin Anaesthesiol IF: 02.100Ahead of Print.No.36Suzetrigine, a selective NaV1.8 inhibitor in acute and chronic pain: mechanistic insights, clinical outcomes, and future perspectives选择性NaV1.8抑制剂Suzetrigine在急慢性疼痛中的应用：机制解析、临床结果与未来展望DOI: 10.1097/ACO.0000000000001599 PloS one IF: 02.600Volume 21, Issue 1No.37Mathematical modeling of glucose regulation and sleep resting heart rate to predict risk of metabolic dysregulation in cancer survivors基于血糖调节与睡眠静息心率的数学建模预测癌症幸存者代谢失调风险DOI: 10.1371/journal.pone.0339461 PloS one IF: 02.600Volume 21, Issue 1No.38FKG-MM: A multi-modal fuzzy knowledge graph with data integration in healthcareFKG-MM：医疗健康领域一种集成数据的多模态模糊知识图谱DOI: 10.1371/journal.pone.0339864 Circulation Research IF: 16.200Volume 138, Issue 1No.39Unraveling Cardiovascular Development and Function: Insights From Single-Cell Omics揭示心血管发育与功能：来自单细胞组学的见解DOI: 10.1161/CIRCRESAHA.125.325793 PloS one IF: 02.600Volume 21, Issue 1No.40Predictive effects of diabetes-related risk factors for falls in community-dwelling people with diabetic peripheral neuropathy based on a logistic regression model基于逻辑回归模型的糖尿病周围神经病变社区患者跌倒相关风险因素预测效应研究DOI: 10.1371/journal.pone.0340262 PLOS global public health IF: 02.500Volume 6, Issue 1No.41Metabolic and inflammatory axes of insulin resistance in normoglycemic adults with high HIV burden高HIV负担血糖正常成人中胰岛素抵抗的代谢与炎症轴DOI: 10.1371/journal.pgph.0005589 PloS one IF: 02.600Volume 21, Issue 1No.42Gene regulatory networks involved in activation of Notch signaling by AGEs in the pathogenesis of diabetic kidney diseaseAGEs激活Notch信号在糖尿病肾病发病机制中的基因调控网络DOI: 10.1371/journal.pone.0335768 PloS one IF: 02.600Volume 21, Issue 1No.43Impaired estimated glomerular filtration rate and associated factors among adult patients living with HIV at Asella Referral and Teaching Hospital, Ethiopia: A cross-sectional study埃塞俄比亚Asella转诊与教学医院成年HIV患者估算肾小球滤过率受损情况及相关因素：一项横断面研究DOI: 10.1371/journal.pone.0330238 The journal of physiology IF: 04.400Ahead of Print.No.44Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation2型糖尿病心脏重塑：病理生理学机制与多尺度计算建模和模拟的机遇DOI: 10.1113/JP287140 Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.45Soda consumption and risk of dementia: The Northern Manhattan study苏打水消费与痴呆风险：Northern Manhattan研究DOI: 10.1177/13872877251411414 Proc Natl Acad Sci U S A IF: 09.100Volume 123, Issue 1No.46Identifying direct risk factors in UK Biobank via simultaneous Bayesian-frequentist model-averaged hypothesis testing using Doublethink利用Doublethink同步贝叶斯-频率派模型平均假设检验识别英国生物样本库中的直接风险因素DOI: 10.1073/pnas.2514138122 Proc Natl Acad Sci U S A IF: 09.100Volume 123, Issue 1No.47Dietary folic acid prevents peripheral neuropathy in mouse models of neural tube defects and type 2 diabetes膳食叶酸可预防神经管缺陷和2型糖尿病小鼠模型中的外周神经病变DOI: 10.1073/pnas.2528095123 Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.48A Randomized Clinical Trial of Kidney Autologous Cell Therapy in Diabetic Kidney Disease糖尿病肾病自体肾细胞疗法的随机临床试验DOI: 10.2215/CJN.0000000969 Kidney360 IF: 03.000Ahead of Print.No.49The Renal miRNA Expression Profile of Pkd1RC/RC Mice Changes Longitudinally with the Progression of the DiseasePkd1RC/RC小鼠肾脏miRNA表达谱随疾病进展呈纵向变化DOI: 10.34067/KID.0000001108 Current opinion in ophthalmology IF: 02.600Ahead of Print.No.50Systemic medications and their impact on age-related macular degeneration development and progression: a review of current evidence系统性药物与年龄相关性黄斑变性发生发展的影响：当前证据综述DOI: 10.1097/ICU.0000000000001198 PloS one IF: 02.600Volume 21, Issue 1No.51Economic evaluation of insulin glargine compared with human insulin for youth with type 1 diabetes in Tanzania and Bangladesh坦桑尼亚和孟加拉国青少年1型糖尿病患者使用胰岛素格列净与人胰岛素的经济学评价比较DOI: 10.1371/journal.pone.0333652 JAMA IF: 55.000Ahead of Print.No.52Some Diabetes Drugs May Slow Frailty Progression in Older Adults部分糖尿病药物或可延缓老年人衰弱进展DOI: 10.1001/jama.2025.23007 JAMA oncology IF: 20.100Ahead of Print.No.53Thyroid Nodule Molecular Classifiers-Reclaiming Deliberation in an Era of AutomationThyroid Nodule Molecular Classifiers——在自动化时代重申审慎决策DOI: 10.1001/jamaoncol.2025.5606 Am J Physiol Renal Physiol IF: 03.400Ahead of Print.No.54Rapid Podocyte Loss in Murine Models Triggers the Formation of Podocyte-Parietal Epithelial Cell Intercellular Bridges鼠类模型中快速足细胞丢失触发足细胞-壁层上皮细胞间桥形成DOI: 10.1152/ajprenal.00292.2025 Mayo Clinic proceedings IF: 06.700Ahead of Print.No.55Mayo Clinic Proceedings and Evolution of Diabetes Management: A Century of Companionship《Mayo Clinic学报》与糖尿病管理演进：百年相伴同行DOI: 10.1016/j.mayocp.2025.11.007 The journal of physiology IF: 04.400Ahead of Print.No.56Longitudinal sex differences in cerebrovascular ageing in older adults: results from the brain in motion study老年人脑血管老化的纵向性别差异：来自大脑运动研究的结果DOI: 10.1113/JP289708 Metallomics : IF: 02.900Ahead of Print.No.57Correlative imaging reveals metal dyshomeostasis and altered zinc coordination environments in a pre-clinical Type 2 diabetes model相关成像技术揭示临床前2型糖尿病模型中的金属稳态失调与锌配位环境改变DOI: 10.1093/mtomcs/mfaf043 Diabetic medicine IF: 03.400Ahead of Print.No.58From narratives to numbers and back: Assessing the psychosocial aspects of diabetes in the era of high technology with emerging qualitative and quantitative methodologies从叙事到数据再回归：运用新兴定性与定量方法评估高科技时代的糖尿病社会心理方面DOI: 10.1111/dme.70206 Journal of glaucoma IF: 01.800Ahead of Print.No.59Reduced Optic Nerve Head Blood Flow Correlates with an Impaired Post-illumination Pupil Response in Glaucoma: The LIGHT Study视盘血流减少与青光眼患者的瞳孔光后反应受损相关：LIGHT研究DOI: 10.1097/IJG.0000000000002672 J Clin Invest IF: 13.600Volume 136, Issue 1No.60Preventing graft re-JAK-tion: safer transplant conditioning enables murine islet allograft tolerance and diabetes reversal预防移植物再“激”反应：更安全的移植预处理方案使小鼠胰岛同种异体移植物耐受与糖尿病逆转成为可能DOI: 10.1172/JCI201105 J Clin Invest IF: 13.600Volume 136, Issue 1No.61Selective disruption of RORγt-CBFβ interaction by IMU-935 prevents RORγt-dependent Th17 autoimmunity but not thymocyte developmentIMU-935选择性破坏RORγt-CBFβ相互作用，抑制RORγt依赖性Th17自身免疫而不影响胸腺细胞发育DOI: 10.1172/JCI185942 J Clin Invest IF: 13.600Volume 136, Issue 1No.62The role of suPAR and related proteins in kidney, heart diseases, and diabetessuPAR及其相关蛋白在肾脏病、心脏病和糖尿病中的作用DOI: 10.1172/JCI197141 J Clin Invest IF: 13.600Volume 136, Issue 1No.63JNK3 regulates β cell responses to incretins in human islets and mouse modelsJNK3调控人类胰岛和小鼠模型中β细胞对肠促胰岛素的应答DOI: 10.1172/JCI185707 The annals of pharmacotherapy IF: 02.300Ahead of Print.No.64Transdermal "Natural GLP-1" Dietary Supplements Violate Law and Place Patients at Risk“天然GLP-1”经皮膳食补充剂既违法又置患者于风险之中DOI: 10.1177/10600280251407145 Cell Physiol Biochem IF: 02.000Volume 59, Issue 6No.653-Acetyl-11-Keto-Beta-Boswellic Acid Inhibits Adipogenesis by Suppressing Autophagy and Inducing AMPK Phosphorylation in 3T3-L1 Cells3-乙酰基-11-酮基-β-乳香酸通过抑制自噬和诱导AMPK磷酸化来抑制3T3-L1细胞的脂肪生成DOI: 10.33594/000000830 Pediatric annals IF: 01.000Volume 55, Issue 1No.66GLP-1 Receptor Agonists in Pediatric Obesity Care: Promise, Pitfalls, and Practical Realities儿科肥胖症管理中GLP-1受体激动剂的应用：前景、挑战与临床现实DOI: 10.3928/19382359-20251125-01 J Clin Invest IF: 13.600Volume 136, Issue 1No.67Mechanisms and clinical implications of gut-brain interactions肠道-大脑相互作用的机制与临床意义DOI: 10.1172/JCI196346 Heart & Lung IF: 02.600Volume 77, Issue No.68Associations of modifiable lifestyle behaviors with cardiovascular–kidney–metabolic syndrome across risk categories: Findings from a U.S. national survey可改变的生活方式行为与心血管-肾脏-代谢综合征跨风险类别的关联：一项美国全国性调查结果DOI: 10.1016/j.hrtlng.2025.102712 Frontiers in genetics IF: 02.800Volume 16, Issue No.69Expanding the spectrum of NUS1-related progressive myoclonic epilepsy: a novel variant and exploratory use of metformin拓展NUS1相关进行性肌阵挛癫痫谱系：一个新变异及二甲双胍的探索性应用DOI: 10.3389/fgene.2025.1665623 Niger Postgrad Med J IF: 00.800Volume 33, Issue 1No.70Prevalence and Determinants of Gestational Diabetes Mellitus at a Tertiary Health Facility in Lagos, Nigeria拉各斯一家三级医疗机构妊娠期糖尿病的患病率及影响因素DOI: 10.4103/npmj.npmj_117_25 Sleep Science IF: 01.800Volume 18, Issue 4No.71Autonomic Cardiovascular Assessment in Obstructive Sleep Apnea Using Beat-to-Beat Blood Pressure: A Pilot Study使用逐搏血压进行阻塞性睡眠呼吸暂停的心血管自主神经评估：一项初步研究DOI: 10.1055/s-0045-1811200 Curēus IF: 01.300Volume 17, Issue 12No.72Unilateral Proptosis Mimicking an Eye Tumour: A Case Report单侧眼球突出误诊为眼肿瘤：病例报告DOI: 10.7759/cureus.98229 J Abdom Wall SurgVolume 4, Issue No.73Simultaneous Abdominal Wall Reconstruction and Panniculectomy in High-Risk Complex Patients: A Retrospective Cohort Study高风险复杂患者中腹壁重建与腹壁整形术同期实施的回顾性队列研究DOI: 10.3389/jaws.2025.15456 Frontiers in public health IF: 03.400Volume 13, Issue No.74Association between ultra-processed food intake, diet quality, and cardiovascular risk factors among adolescents in Antioquia, Colombia哥伦比亚安蒂奥基亚省青少年超加工食品摄入、饮食质量与心血管风险因素之间的关联研究DOI: 10.3389/fpubh.2025.1710967 Frontiers in public health IF: 03.400Volume 13, Issue No.75Cardiovascular risk factors across job roles and work shifts in a Brazilian Military Police cohort: a cross-sectional study巴西军事警察队列中不同工作岗位与工作班次的心血管风险因素：一项横断面研究DOI: 10.3389/fpubh.2025.1716547 Frontiers in public health IF: 03.400Volume 13, Issue No.76Experiences of recent weight-management attempts: insights from a web-based cross-sectional study近期体重管理尝试的体验：一项基于网络横断面研究的洞见DOI: 10.3389/fpubh.2025.1709949 JSLS IF: 01.800Volume 29, Issue 4No.77Prospective Evaluation of Conventional and Novel Factors Influencing Gastric Wall Thickness in Bariatric Surgery Patients减重手术患者胃壁厚度影响因素的前瞻性评估：常规与新型因子的作用DOI: 10.4293/JSLS.2025.00106 World J Gastrointest Endosc IF: 01.800Volume 17, Issue 12No.78Quality of life, dumping symptoms, and weight bias internalization after endoscopic bariatric revisional therapies内镜减重修正治疗后患者的生活质量、倾倒综合征症状及体重偏见内化DOI: 10.4253/wjge.v17.i12.113467 World journal of nephrologyVolume 14, Issue 4No.79Obesity and pediatric renal transplant: An unholy alliance肥胖与儿童肾移植：一种不良的联盟DOI: 10.5527/wjn.v14.i4.106428 World J Gastrointest Surg IF: 01.700Volume 17, Issue 12No.80Effect of resected gastric volume on weight loss after sleeve gastrectomy: A retrospective clinical study切除胃体积对袖状胃切除术后体重减轻的影响：一项回顾性临床研究DOI: 10.4240/wjgs.v17.i12.113571 Frontiers in nutrition IF: 05.100Volume 12, Issue No.81Hedonic hunger and eating behavior after low-carbohydrate versus low-fat diets in females with lipedema and obesity脂肪水肿合并肥胖女性中，低碳水化合物与低脂饮食对享乐性饥饿及进食行为的影响DOI: 10.3389/fnut.2025.1716592 Revista de salud publicaVolume 27, Issue 3No.82[Anthropometric identification of excess adiposity in Argentine adults according to the new concepts of obesity]阿根廷成年人体测量识别脂肪含量过多：基于肥胖新概念的探讨DOI: 10.15446/rsap.V27n3.119461 World journal of hepatology IF: 02.500Volume 17, Issue 12No.83Microplastics in metabolic dysfunction-associated steatotic liver disease: An emerging threat to liver health代谢功能障碍相关脂肪性肝病中的微塑料：对肝脏健康的新兴威胁DOI: 10.4254/wjh.v17.i12.111198 Curēus IF: 01.300Volume 17, Issue 11No.84Patient Perceptions of Orthopedic Surgeon-Led Nutrition Discussions Regarding Arthroplasty Care: A Single-Center Retrospective Study患者对骨科医生主导的关节置换术营养讨论的看法：一项单中心回顾性研究DOI: 10.7759/cureus.98116 Curēus IF: 01.300Volume 17, Issue 11No.85The Impact of Regular Physical Activity on Children's Health Parameters: A Critical Literature Analysis of Metabolism, the Musculoskeletal System, Respiratory System Diseases, and Neuropsychiatry规律体力活动对儿童健康参数的影响：基于代谢、肌肉骨骼系统、呼吸系统疾病及神经精神病学的批判性文献分析DOI: 10.7759/cureus.98198 Niger Postgrad Med J IF: 00.800Volume 33, Issue 1No.86Sex-specific Anthropometric Variations and the Influence of Central Obesity on Thyroid Hormone Regulation: A Cross-sectional Study性别特异性人体测量学差异与中心性肥胖对甲状腺激素调节的影响：一项横断面研究DOI: 10.4103/npmj.npmj_375_25 Niger Postgrad Med J IF: 00.800Volume 33, Issue 1No.87The Clinical Patterns and Disease Severity of Knee Osteoarthritis in Duhok/Kurdistan Region, Iraq伊拉克库尔德斯坦地区杜胡克市膝骨关节炎的临床模式与疾病严重程度DOI: 10.4103/npmj.npmj_345_25 World journal of hepatology IF: 02.500Volume 17, Issue 12No.88Steatotic liver disease in patients with chronic hepatitis C慢性丙型肝炎患者的脂肪性肝病DOI: 10.4254/wjh.v17.i12.113639 Veterinary pathology IF: 01.700Ahead of Print.No.89Spontaneous and experimentally induced lesions in NOD-scid gamma and other NOD-derived mouse strainsNOD-scid gamma及其他NOD衍生小鼠品系的自发性和实验性病变DOI: 10.1177/03009858251403172 Sci Diabetes Self Manag Care IF: 02.200Ahead of Print.No.90Continuous Glucose Monitor Use and Diabetes Self-Management Behaviors in Adults Managed in Specialty Clinic: Qualitative Descriptive Study专科诊所管理的成人患者使用持续葡萄糖监测系统与其糖尿病自我管理行为：一项定性描述性研究DOI: 10.1177/26350106251405751 The FASEB journal : IF: 04.200Volume 40, Issue 1No.91Differential Activation of p53-Lamin A/C and p16-Rb-Mediated Senescence Pathways in Trophoblasts From Pregnancies Complicated by Type A2 Gestational Diabetes Mellitus在A2型妊娠期糖尿病并发症妊娠中，滋养细胞p53-Lamin A/C和p16-Rb介导的衰老通路差异激活DOI: 10.1096/fj.202503771RR Sci Diabetes Self Manag Care IF: 02.200Ahead of Print.No.92The Diabetes Education Arena: Results of the 2025 ADCES National Practice Survey of Diabetes Care and Education Specialists糖尿病教育领域：2025年ADCES糖尿病护理与教育专家全国实践调查结果DOI: 10.1177/26350106251401514 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.93Precision nutrition in weight loss and neuroendocrine control of people with obesity: The study protocol of a factorial randomised controlled trial (GenON Programme)精准营养在肥胖人群减重与神经内分泌调控中的作用：一项析因随机对照试验的研究方案（GenON Programme）DOI: 10.1111/dom.70414 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.94Age disparities in SGLT2 inhibitor prescription among people with type 2 diabetes: The role of frailty and sex2型糖尿病患者中SGLT2抑制剂处方的年龄差异：虚弱与性别的作用DOI: 10.1111/dom.70421 Health science reports IF: 02.100Volume 9, Issue 1No.95A Scoping Review of Noncommunicable Disease Programs Evaluation: Bridging Gaps and Improving Frameworks in Primary Healthcare非传染性疾病项目评估的范围综述：弥合初级卫生保健中的差距与改进框架DOI: 10.1002/hsr2.71444 World journal of diabetes IF: 04.600Volume 16, Issue 12No.96Serum C-reactive protein and C-reactive protein derived markers in diabetic microvascular complications血清C反应蛋白及其衍生标志物在糖尿病微血管并发症中的作用DOI: 10.4239/wjd.v16.i12.113237 World journal of diabetes IF: 04.600Volume 16, Issue 12No.97Glycemic control and determinants among type 2 diabetes mellitus in a regional hospital in South West Region, Cameroon喀麦隆西南大区一家地区医院2型糖尿病患者的血糖控制情况及影响因素DOI: 10.4239/wjd.v16.i12.109233 World journal of diabetes IF: 04.600Volume 16, Issue 12No.98Perirenal fat and alcohol consumption contribute to marginal bone loss after dental implant surgery in type 2 diabetes肾周脂肪与酒精消费影响2型糖尿病患者种植牙术后边缘骨丢失DOI: 10.4239/wjd.v16.i12.114003 World journal of diabetes IF: 04.600Volume 16, Issue 12No.99Longitudinal assessment of pancreatic exocrine dysfunction in type 1 diabetes1型糖尿病患者胰腺外分泌功能障碍的纵向评估DOI: 10.4239/wjd.v16.i12.112799 World journal of diabetes IF: 04.600Volume 16, Issue 12No.100Glycemic control, weight-loss effects, and safety of cotadutide in individuals with type 2 diabetes: A systematic review and meta-analysis双受体激动剂Cotadutide用于2型糖尿病的血糖控制、减重效果及安全性：一项系统评价和荟萃分析DOI: 10.4239/wjd.v16.i12.112830 Sleep Science IF: 01.800Volume 18, Issue 4No.101Substance Use, Poor Sleep, and Gestational Diabetes: Concerns in Adolescent Pregnancy物质使用、睡眠不良与妊娠期糖尿病：青少年妊娠中的关切DOI: 10.1055/s-0045-1809992 World journal of orthopedics IF: 02.300Volume 16, Issue 12No.102Intertwined roles of microRNA-155 and metformin in osteoarthritis: Novel potential diagnostic, prognostic, and therapeutic modulatorsMicroRNA-155与二甲双胍在骨关节炎中的交织作用：新型潜在的诊断、预后及治疗调节剂DOI: 10.5312/wjo.v16.i12.110992 Am J Lifestyle Med IF: 01.300Ahead of Print.No.103Improving Health Outcomes for Oklahomans: A Mixed-Methods Evaluation of a Lifestyle Medicine Intervention Program改善俄克拉荷马州居民健康结局：一项生活方式医学干预项目的混合方法评估DOI: 10.1177/15598276251413547 Curēus IF: 01.300Volume 17, Issue 12No.104Eosinophilic Granulomatosis With Polyangiitis Presenting as Mononeuritis Multiplex in a Diabetic Patient: Diagnostic and Therapeutic Challenges嗜酸性肉芽肿性多血管炎在糖尿病患者中表现为多发性单神经炎：诊断与治疗挑战DOI: 10.7759/cureus.98219 J Clin Exp Hepatol IF: 03.200Volume 16, Issue 1No.105Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Facts and Hopes代谢功能障碍相关脂肪性肝病（MASLD）的管理：事实与展望DOI: 10.1016/j.jceh.2025.103411 F1000ResearchVolume 14, Issue No.106Case Report: Gastro-bronchial fistula complicating a sleeve gastrectomy: from a glimmer of hope to a plight病例报告：袖状胃切除术的罕见并发症——胃支气管瘘：从一线希望到治疗困境DOI: 10.12688/f1000research.169504.2 F1000ResearchVolume 14, Issue No.107Salivary microbiome and periodontopathogen/denitrifying bacteria associated with gingivitis and periodontitis in people with type 2-diabetes2型糖尿病患者唾液微生物组中与牙龈炎和牙周炎相关的牙周病原菌及反硝化细菌研究DOI: 10.12688/f1000research.161731.3 Qatar medical journalVolume 2025, Issue 4No.108Understanding empyema in Qatar: Microbiological profiles, clinical outcomes, and targeted treatment through a retrospective analysis理解卡塔尔的脓胸：通过回顾性分析解读微生物谱、临床结局及靶向治疗DOI: 10.5339/qmj.2025.110 JHEP reports IF: 07.500Volume 8, Issue 1No.109Interleukin-18 binding protein deficiency results in gut microbiota dysbiosis and aggravated diet-induced MASH in mice白介素-18结合蛋白缺乏导致肠道菌群失调并加剧饮食诱导的小鼠MASHDOI: 10.1016/j.jhepr.2025.101629 World J Gastrointest Oncol IF: 02.500Volume 17, Issue 12No.110Clinical significance of citrullinated glial fibrillary acidic protein in predicting outcomes in hepatocellular carcinoma瓜氨酸化胶质纤维酸性蛋白预测肝细胞癌临床结局的临床意义DOI: 10.4251/wjgo.v17.i12.110877 Revista de salud publicaVolume 27, Issue 1No.111[Frequency of some diseases that affect men's health of Andes, Antioquia]影响哥伦比亚安第斯市男性健康的部分疾病频率DOI: 10.15446/rsap.V27n1.114072 Frontiers in public health IF: 03.400Volume 13, Issue No.112The hidden health equity crisis: readability assessment of online information regarding periodontitis-diabetes relationship隐匿的健康公平危机：牙周炎-糖尿病关系在线信息的可读性评估DOI: 10.3389/fpubh.2025.1710193 Frontiers in public health IF: 03.400Volume 13, Issue No.113Navigating adulthood with juvenile-onset type 1 diabetes: a scoping review on education, employment and quality of life跨越成人期：青少年发病1型糖尿病对教育、就业及生活质量影响的范围综述DOI: 10.3389/fpubh.2025.1707581 Journal of Orthopaedics IF: 01.500Volume 70, Issue No.114Factors associated with in-hospital death within 30 days after shoulder arthroplasty: a retrospective analysis肩关节置换术后30天内发生院内死亡的相关因素：一项回顾性分析DOI: 10.1016/j.jor.2025.11.028 Metabolism open IF: 02.700Volume 29, Issue No.115Machine learning-based binary classification of elevated HbA1c (≥6.5 %) for risk assessment基于机器学习的二分类预测糖化血红蛋白升高风险DOI: 10.1016/j.metop.2025.100428 NIHR open researchVolume 5, Issue No.116My Diabetes & Me: study protocol for a randomised controlled trial to test the clinical and cost-effectiveness of a diabetes self-management education programme for adults with intellectual disabilities我的糖尿病与我：一项评估针对智力残疾成人糖尿病自我管理教育方案临床与成本效益的随机对照试验研究方案DOI: 10.3310/nihropenres.13964.1 World J Gastrointest PathophysiolVolume 16, Issue 4No.117Gastric motility and its association with adiposity and metabolic health in a cohort of Sri Lankan office workers斯里兰卡办公室工作者队列中胃动力及其与肥胖程度和代谢健康的关联DOI: 10.4291/wjgp.v16.i4.112536 Int J Endocrinol IF: 02.300Volume 2025, Issue No.118Gestational Diabetes Is Associated With Abnormalities in Glucose Excursion in Early Pregnancy妊娠期糖尿病与孕早期血糖波动异常相关DOI: 10.1155/ije/9922593 World journal of nephrologyVolume 14, Issue 4No.119Non-traditional cardiovascular risk factors after kidney transplantation肾移植术后非传统心血管风险因素DOI: 10.5527/wjn.v14.i4.110896 World journal of nephrologyVolume 14, Issue 4No.120Kidney transplant outcomes in obese pediatric patients肥胖儿童患者的肾移植结果DOI: 10.5527/wjn.v14.i4.106536 World journal of nephrologyVolume 14, Issue 4No.121Dialysis Symptom Index: Patient-reported outcome measures study of dialysis patients in low resource settings in India透析症状指数：印度资源匮乏地区透析患者患者报告结局指标研究DOI: 10.5527/wjn.v14.i4.111639 World journal of nephrologyVolume 14, Issue 4No.122Predictive value of biomarkers for tubulointerstitial and glomerular interactions in diabetic nephropathy生物标志物对糖尿病肾病中肾小管间质与肾小球相互作用的预测价值DOI: 10.5527/wjn.v14.i4.103649 World journal of nephrologyVolume 14, Issue 4No.123Dietary management of patients with type 2 diabetes and chronic kidney disease: A comprehensive literature review2型糖尿病与慢性肾脏病患者的饮食管理：一项综合文献回顾DOI: 10.5527/wjn.v14.i4.109875 World journal of nephrologyVolume 14, Issue 4No.124Relationship between vitamin D and post-transplant diabetes mellitus in kidney transplant recipients肾移植受者中维生素D与移植后糖尿病的关系DOI: 10.5527/wjn.v14.i4.113300 World journal of nephrologyVolume 14, Issue 4No.125Sodium-glucose cotransporter-2 inhibitors beyond glycemic control: Their role in acute kidney injury recovery钠-葡萄糖协同转运蛋白2抑制剂超越血糖控制：其在急性肾损伤恢复中的作用DOI: 10.5527/wjn.v14.i4.112302 World journal of nephrologyVolume 14, Issue 4No.126Updates in the management of intradialytic hypotension: Emerging strategies and innovations透析中低血压管理进展：新兴策略与创新DOI: 10.5527/wjn.v14.i4.109168 World J Gastroenterol IF: 05.400Volume 31, Issue 47No.127Sex-based differences in hepatitis delta virus infection: Insights from the Italian PITER hepatitis delta virus cohort基于性别的丁型肝炎病毒感染差异：来自意大利PITER丁型肝炎病毒队列的见解DOI: 10.3748/wjg.v31.i47.111637 World journal of clinical cases IF: 01.000Volume 13, Issue 35No.128Predictors of intensive care unit admission rates in patients with acute cholangitis急性胆管炎患者入住重症监护室率的预测因素DOI: 10.12998/wjcc.v13.i35.115090 Frontiers in nutrition IF: 05.100Volume 12, Issue No.129Targeting gut microbiota with short-chain fructo-oligosaccharides prebiotic fibers to support metabolic health in overweight prediabetic adults: a randomized, double-blinded, placebo-controlled study靶向肠道菌群：短链低聚果糖（scFOS）益生元纤维支持超重糖尿病前期成人代谢健康的随机、双盲、安慰剂对照研究DOI: 10.3389/fnut.2025.1718169 World Journal of Cardiology IF: 02.800Volume 17, Issue 12No.130Complex interrelationship and therapeutic advances in diabetic patients with atrial fibrillation糖尿病合并心房颤动患者的复杂相互关系与治疗进展DOI: 10.4330/wjc.v17.i12.114575 Health science reports IF: 02.100Volume 9, Issue 1No.131Predictors of 12-Month MACE Among Diabetic, Prediabetic, and Normoglycemic Patients Undergoing Elective Percutaneous Coronary Intervention: 10 Years' Experience From Tehran Heart Center接受择期经皮冠状动脉介入治疗的糖尿病、糖尿病前期及血糖正常患者12个月主要不良心脏事件的预测因素：来自德黑兰心脏中心的10年经验DOI: 10.1002/hsr2.71369 World J Gastrointest Surg IF: 01.700Volume 17, Issue 12No.132Impact of statin therapy on postoperative outcomes following colorectal cancer surgery: A systematic review他汀类药物对结直肠癌手术术后结局影响的系统综述DOI: 10.4240/wjgs.v17.i12.112841 Int J Mol Med IF: 05.800Volume 57, Issue 2No.133miR‑205: A dual regulator of angiogenesis in health and disease (Review)miR-205：健康与疾病中血管生成的双重调节因子（综述）DOI: 10.3892/ijmm.2025.5722 World journal of diabetes IF: 04.600Volume 16, Issue 12No.134Association of ICAM-1 Gene Polymorphisms with Diabetic Retinopathy in T2DM Patients from Northern India: Case-control and meta-analysis印度北部2型糖尿病患者ICAM-1基因多态性与糖尿病视网膜病变的关联：病例对照研究及荟萃分析DOI: 10.4239/wjd.v16.i12.110770 World journal of nephrologyVolume 14, Issue 4No.135Predictors of non-diabetic kidney disease in diabetics: A Saudi Arabian perspective糖尿病患者非糖尿病性肾病的预测因素：沙特阿拉伯视角DOI: 10.5527/wjn.v14.i4.111613 Niger Postgrad Med J IF: 00.800Volume 33, Issue 1No.136Prevalence and Predictors of Rapid Estimated Glomerular Filtration Rate Decline in Patients with Non-albuminuric Diabetic Kidney Disease: A Single-centre Retrospective Cohort Study非白蛋白尿性糖尿病肾病患者中快速估计肾小球滤过率下降的患病率与预测因素：一项单中心回顾性队列研究DOI: 10.4103/npmj.npmj_341_25 World journal of nephrologyVolume 14, Issue 4No.137Baseline predictors of in-hospital mortality among patients with chronic kidney disease admitted to the emergency department基线预测因子对慢性肾脏病患者急诊入院后院内死亡率的影响DOI: 10.5527/wjn.v14.i4.109382 World J Gastroenterol IF: 05.400Volume 31, Issue 48No.138Gut microbiota: An overlooked target in dyslipidemia management肠道菌群：血脂异常管理中一个被忽视的靶点DOI: 10.3748/wjg.v31.i48.113178 World journal of diabetes IF: 04.600Volume 16, Issue 12No.139Beyond the left ventricle: Right ventricular dysfunction as a critical determinant in type 1 diabetes-related cardiomyopathy超越左心室：右心室功能障碍是1型糖尿病相关心肌病的关键决定因素DOI: 10.4239/wjd.v16.i12.114485 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.140The importance of treatment sequencing with SGLT2 inhibitors and GLP-1 receptor agonists combination for kidney function preservation in type 2 diabetes对于合并使用SGLT2抑制剂和GLP-1受体激动剂的2型糖尿病患者，治疗顺序对肾功能保护的重要性DOI: 10.1111/dom.70445 World journal of diabetes IF: 04.600Volume 16, Issue 12No.141Effect of glucagon-like peptide-1 receptor agonists on gastric mucosal visibility during upper endoscopy in Asian patients with diabetesGLP-1受体激动剂对亚洲糖尿病患者上消化道内镜检查中胃黏膜可见度的影响DOI: 10.4239/wjd.v16.i12.112694 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.142Comparative safety of glucose-lowering medications on depression in adults with type 2 diabetes2型糖尿病成人患者中降糖药物对抑郁症影响的比较安全性研究DOI: 10.1111/dom.70415 World journal of diabetes IF: 04.600Volume 16, Issue 12No.143Impact of diabetes mellitus on mortality and atrial fibrillation in hypertrophic cardiomyopathy: A systematic review and meta-analysis糖尿病对肥厚型心肌病患者死亡率和心房颤动的影响：一项系统评价和荟萃分析DOI: 10.4239/wjd.v16.i12.110494 World journal of nephrologyVolume 14, Issue 4No.144Risk factors for developing acute kidney injury after heart transplant: A systematic review and meta-analysis心脏移植后发生急性肾损伤的风险因素：一项系统综述和荟萃分析DOI: 10.5527/wjn.v14.i4.110791 World journal of nephrologyVolume 14, Issue 4No.145Cardio-kidney-metabolic protective effects of semaglutide across the spectrum of chronic kidney disease司美格鲁肽在慢性肾脏病谱系中的心脏-肾脏-代谢保护作用DOI: 10.5527/wjn.v14.i4.109457 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.146Performance of continuous glucose monitoring systems (CGMs) during commercial flights in T1DM: A within-subject comparative pilot study1型糖尿病患者商业飞行期间连续血糖监测系统性能：一项个体内比较先导研究DOI: 10.1111/dom.70418 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.147Challenges in glycaemic control among women with type 1 diabetes and the role of MiniMed 780G system: A narrative review1型糖尿病女性面临的血糖控制挑战及MiniMed 780G系统的作用DOI: 10.1111/dom.70377 World journal of diabetes IF: 04.600Volume 16, Issue 12No.148Rheb1 signaling and the fate of pancreatic β cells: Toward a new frontier in diabetes therapyRheb1信号通路与胰腺β细胞的命运：通往糖尿病治疗的新前沿DOI: 10.4239/wjd.v16.i12.108609 World journal of diabetes IF: 04.600Volume 16, Issue 12No.149Addressing the dual challenge: Managing smoking cessation in patients with diabetes应对双重挑战：糖尿病患者的戒烟管理DOI: 10.4239/wjd.v16.i12.105241 Curēus IF: 01.300Volume 17, Issue 12No.150Mediterranean Diet as a Management Strategy for Gestational Diabetes Mellitus: A Narrative Review of the Literature地中海饮食作为妊娠期糖尿病管理策略：文献叙述性综述DOI: 10.7759/cureus.98254 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.151Elevated serum chromogranin A levels are independently associated with metabolic and inflammatory disturbances in polycystic ovary syndrome血清嗜铬粒蛋白A水平升高与多囊卵巢综合征的代谢和炎症紊乱独立相关DOI: 10.3389/fendo.2025.1682910 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.152Recent advances in incretin-based therapy for the treatment of cognitive impairment associated to the type 2 diabetes mellitus: preclinical and clinical studies - a narrative review肠促胰素疗法治疗2型糖尿病相关认知障碍的最新进展：临床前及临床研究综述DOI: 10.3389/fendo.2025.1696419 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.153The perfect storm: unraveling the interplay of genetic predisposition and viral triggers in type 1 diabetes pathogenesis完美风暴：剖析遗传易感性与病毒触发因素在1型糖尿病发病机制中的相互作用DOI: 10.3389/fendo.2025.1734431 Qatar medical journalVolume 2025, Issue 4No.154Health literacy levels and predictors among type 2 diabetes patients in Qatar: An analytical cross-sectional study卡塔尔2型糖尿病患者的健康素养水平及其影响因素：一项分析性横断面研究DOI: 10.5339/qmj.2025.104 World Journal of Cardiology IF: 02.800Volume 17, Issue 12No.155Pentadecanoic acid (C15:0) and cardiovascular disease: A narrative review十五烷酸（C15:0）与心血管疾病：一项叙述性综述DOI: 10.4330/wjc.v17.i12.110861 World J Gastrointest PathophysiolVolume 16, Issue 4No.156Metabolic changes after hepatectomy: Implications for perioperative management and long-term outcomes肝切除术后代谢变化：对围手术期管理与长期结局的启示DOI: 10.4291/wjgp.v16.i4.109860 World J Gastrointest PathophysiolVolume 16, Issue 4No.157Pathophysiology of depression and anxiety in metabolic dysfunction-associated steatotic liver disease代谢功能障碍相关脂肪性肝病中抑郁和焦虑的病理生理学DOI: 10.4291/wjgp.v16.i4.111029 World J Gastrointest PathophysiolVolume 16, Issue 4No.158Gluten's silent strike: Unmasking its impact on liver health麸质的沉默打击：揭示其对肝脏健康的影响DOI: 10.4291/wjgp.v16.i4.111957 World journal of hepatology IF: 02.500Volume 17, Issue 12No.159Interplay between intestinal permeability and metabolic dysfunction-associated steatotic liver disease: Could there be a role for extra virgin olive oil consumption?肠道通透性与代谢功能障碍相关脂肪性肝病之间的相互作用：特级初榨橄榄油消费是否扮演角色？DOI: 10.4254/wjh.v17.i12.110076 Curēus IF: 01.300Volume 17, Issue 11No.160Ancient Schwannoma of the Submandibular Gland in a Patient With Acromegaly: A Case Report肢端肥大症患者颌下腺陈旧性神经鞘瘤：病例报告DOI: 10.7759/cureus.98167 Curēus IF: 01.300Volume 17, Issue 11No.161The Thyroid Twist: How GLP-1 Agonists Are Influencing Autoimmune Thyroid Care甲状腺诊疗新视角：GLP-1激动剂如何影响自身免疫性甲状腺疾病管理DOI: 10.7759/cureus.98153 Endocrinology and metabolism IF: 04.200Volume 40, Issue 6No.162SGLT2 Inhibitors as Systemic Metabolic Modulators: Linking Glucose Excretion to Liver Function RestorationSGLT2抑制剂作为系统性代谢调节剂：连接葡萄糖排泄与肝功能恢复DOI: 10.3803/EnM.2025.2786 Adv Exp Med BiolVolume 1490, Issue No.163The Role of Epigenetics in Preeclampsia表观遗传学在子痫前期中的作用DOI: 10.1007/978-3-032-03402-1_40 158 Diabetes Mellitus(DM) 糖尿病 73 Obesity 肥胖症 48 Insulin 胰岛素 26 Type 2 diabetes mellitus(T2DM) 2型糖尿病 12 Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA) 胰高血糖素样肽-1受体激动剂 12 Diabetic Kidney Disease(DKD) 糖尿病肾脏病 10 Metabolic Syndrome 代谢综合征 8 Diabetic Retinopathy 糖尿病视网膜病 6 Gestational Diabetes Mellitus(GDM) 妊娠糖尿病 5 Hypoglycemic Agents 降糖药 5 Metformin 二甲双胍 4 Semaglutide 司美格鲁肽 3 Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i) 钠-葡萄糖协同转运蛋白2抑制剂 3 Dapagliflozin 达格列净 3 Diabetic acidosis 糖尿病性酸中毒 2 Diabetic Cardiomyopathies 糖尿病心肌病 2 Diabetic Foot 糖尿病足 2 Diabetic Neuropathies 糖尿病性神经病变 2 Liraglutide 利拉鲁肽 2 Tirzepatide 替尔泊肽 2 Dipeptidyl-Peptidase IV Inhibitors(DPP-4i) 二肽基肽酶-4抑制剂 1 Gastrointestinal lipase inhibitor 胃肠道脂肪酶抑制剂 1 Orlistat 奥利司他 1 Type 1 diabetes mellitus(T1DM) 1型糖尿病 1 Exenatide 艾塞那肽 1 Empagliflozin 恩格列净 1 Sotagliflozin 索格列净 1 Canagliflozin 卡格列净 编辑：天纳乾坤 审校：天纳乾坤

2024年4月30日，海军军医大学第二附属医院（上海长征医院）殷浩教授团队联合中国科学院分子细胞科学卓越创新中心程新教授团队，在国际知名学术期刊《细胞发现》（Cell Discovery，IF：33.5）在线发表了题为“Treating a type 2 diabetic patient with impaired pancreatic islet function by personalized endoderm stem cell-derived islet tissue”的研究成果。这是国际上首次利用诱导多能干细胞（iPS细胞/iPSC）来源的自体再生胰岛移植，成功治愈胰岛功能严重受损糖尿病的病例报道。上海长征医院器官移植中心主任殷浩教授表示，相关科研团队历经十余年研究，利用患者血液PBMC重编程为自体iPSC细胞，并使用国际首创技术使之转变为“种子细胞”即内胚层干细胞（Endoderm stem cell, EnSC），最终实现在体外再造胰岛组织（E-islet）。研究团队建立了GMP条件下的体外定向分化体系，以患者自体EnSCs为种子，经过两个关键中间步骤，制备了在形态、内分泌细胞组成及比例、纯度、基因表达、体内外功能等方面与成体胰岛相近的再生胰岛组织E-islets，并利用免疫缺损SCID-beige小鼠模型、Streptozocin诱导的小鼠/食蟹猴糖尿病模型以及人源化小鼠模型分别评估了E-islet的体内存活、成瘤风险、体内功能及免疫原。T2D患者自体E-islet移植临床前研究结果在临床前研究的基础上，海军军医大学上海长征医院临床团队成功将120万胰岛当量（IEQ）的E-islets以经皮肝门静脉介入输注方式移植到患者肝脏内，定期观察安全性及有效性相关指标。该项技术的首例受益者59岁，有25年2型糖尿病病史，并发展为终末期糖尿病肾病（尿毒症），2017年6月出现终末期糖尿病肾病并接受肾移植。但由于其胰岛功能近乎衰竭，每天需要多次注射胰岛素，未来存在极大的糖尿病严重并发症风险。2021年7月19日，由于对低血糖的担忧以及考虑血糖控制不佳对供体肾脏长期生存的不利影响，该患者在上海长征医院接受了自体再生胰岛移植治疗，从术后第11周开始完全脱离外源胰岛素，其他降糖药（拜糖平、二甲双胍）术后逐步减量，并在第48周和56周实现脱离。最后，患者术后空腹C肽水平较术前增加了2倍；MMTT实验揭示餐后胰岛素及C肽分泌较术前均显著增加，提示胰岛功能恢复；肾脏功能等随访指标均处于正常范围，也提示该疗法可避免糖尿病并发症的进展。 T2D患者自体E-islet移植临床研究结果长征医院透露，除了首例严重2型糖尿病患者，上述联合团队也成功开展并治愈了多例脆性1型糖尿病患者。殷浩表示，未来团队将聚焦干细胞来源再生胰岛组织的相关研究，进一步开发无需免疫抑制的“通用型”再生胰岛组织，从而为广大长期依赖胰岛素注射的糖尿病患者提供新的治愈疗法。撰文 | 梅斯医学综合整理编辑 | 阿拉斯加宝● 震撼！科室绩效分配全凭主任一人做主，分配不公导致医生都快跑光了！科主任不干活，却分走一半奖金！科主任权力咋那么大？好事还是坏事？● 热议！医生抱怨：明明下了夜班、周末在休息，可只要开会、培训，你就得去，不去罚绩效！我们不多的休息时间为何总是被医院占用？● 教训！医院为患者做CT检查，没给穿防护服，立案处罚！近期发生多起！罚款4千！医生困惑：不穿竟然违法？咋回事？好像都没穿过……版权说明：梅斯医学（MedSci）是国内领先的医学科研与学术服务平台，致力于医疗质量的改进，为临床实践提供智慧、精准的决策支持，让医生与患者受益。欢迎个人转发至朋友圈，谢绝媒体或机构未经授权以任何形式转载至其他平台。点击下方「阅读原文」 立刻下载梅斯医学APP！