预约演示
更新于：2026-10-28
Bexagliflozin
贝沙格列净
更新于：2026-10-28
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2023-01-20), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C24H29ClO7 |
InChIKeyBTCRKOKVYTVOLU-SJSRKZJXSA-N |
CAS号1118567-05-7 |
关联
26
项与 贝沙格列净 相关的临床试验NCT07547878
A Pilot Randomized Clinical Trial to Assess Feasibility, Safety, and Efficacy of Rapid, Simultaneous Therapy Initiation in Chronic Kidney Disease and Type 2 Diabetes: RAPID-CKD
The goal of this clinical trial is to learn if starting four kidney disease medicines quickly and together (a rapid treatment approach) is safe and works well in people with type 2 diabetes and chronic kidney disease.
The main questions it aims to answer are:
* Is it safe to start these medicines over a short period of time?
* How often do kidney function changes or high potassium levels occur?
* Does this approach lower protein in the urine (a sign of kidney damage)?
* How many participants are able to stay on all four medicines over 6 months?
Researchers will compare this approach to usual care, where medicines are started one at a time over several months.
Participants will:
Be assigned by chance to either this approach or usual care Start up to four approved kidney medicines over about 8 weeks (rapid treatment approach) or follow standard care Have regular clinic visits and lab tests to check kidney function and potassium levels Be followed for about 6 months
The main questions it aims to answer are:
* Is it safe to start these medicines over a short period of time?
* How often do kidney function changes or high potassium levels occur?
* Does this approach lower protein in the urine (a sign of kidney damage)?
* How many participants are able to stay on all four medicines over 6 months?
Researchers will compare this approach to usual care, where medicines are started one at a time over several months.
Participants will:
Be assigned by chance to either this approach or usual care Start up to four approved kidney medicines over about 8 weeks (rapid treatment approach) or follow standard care Have regular clinic visits and lab tests to check kidney function and potassium levels Be followed for about 6 months
开始日期2026-04-08 |
申办/合作机构 |
NCT06600178
Innovative Therapy to Treat Women With Angina With Nonobstructive Coronary Artery Disease (ANOCA) and Coronary Microvascular Disease
The goal of this clinical trial is to that Sodium-glucose cotransporter 2 inhibitors treatment will improve Coronary Microvascular Disease with anginal symptoms associated with non-obstructive coronary disease in women. The main questions it aims to answer are:
Aim 1: Test the hypothesis that Sodium-glucose cotransporter 2 inhibitors treatment improves coronary microvascular disease in women with no evidence of epicardial obstructive coronary artery disease.
Aim 2: Test the hypothesis that Sodium-glucose cotransporter 2 inhibitors treatment improves angina symptoms and other quality of life measurements associated with the improvement of CFR.
AIM 3: Identify the effect of Sodium-glucose cotransporter 2 inhibition on inflammation pathways and markers of systemic Research will compare Brezavvy to placebo
Participants will:
* Take study drug or placebo for 12 weeks
* Stress Cardiac magnetic resonance imaging
* 12 lead electrocardiograms
* Complete questionnaires
Aim 1: Test the hypothesis that Sodium-glucose cotransporter 2 inhibitors treatment improves coronary microvascular disease in women with no evidence of epicardial obstructive coronary artery disease.
Aim 2: Test the hypothesis that Sodium-glucose cotransporter 2 inhibitors treatment improves angina symptoms and other quality of life measurements associated with the improvement of CFR.
AIM 3: Identify the effect of Sodium-glucose cotransporter 2 inhibition on inflammation pathways and markers of systemic Research will compare Brezavvy to placebo
Participants will:
* Take study drug or placebo for 12 weeks
* Stress Cardiac magnetic resonance imaging
* 12 lead electrocardiograms
* Complete questionnaires
开始日期2025-07-15 |
申办/合作机构 |
NCT05612594
Adipose Dysfunction, Imaging, Physiology, and Outcomes With SGLT2i's for Sleep Apnea: The ADIPOSA Study
The goal of this clinical trial is to test if bexagliflozin lowers the sleep apnea severity in adults who are overweight or obese with moderate to severe obstructive sleep apnea (OSA) compared with a placebo (look-alike substance that contains no active drug).
The main question it aims to answer is:
* If SGLT2i will reduce anatomic and physiologic traits, clinical measures of OSA and sleep deficiency in participants
* If improvement in clinical measures are because of improvement in the anatomic and physiologic traits.
Participants will be placed on either drug or placebo and get routine normal care for 6 months. At the start and end of the study, participants will undergo different clinical measurements to see if the drug makes the sleep apnea better.
The main question it aims to answer is:
* If SGLT2i will reduce anatomic and physiologic traits, clinical measures of OSA and sleep deficiency in participants
* If improvement in clinical measures are because of improvement in the anatomic and physiologic traits.
Participants will be placed on either drug or placebo and get routine normal care for 6 months. At the start and end of the study, participants will undergo different clinical measurements to see if the drug makes the sleep apnea better.
开始日期2024-03-27 |
申办/合作机构  Yale University [+1] |
100 项与 贝沙格列净 相关的临床结果
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100 项与 贝沙格列净 相关的转化医学
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100 项与 贝沙格列净 相关的专利（医药）
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50
项与 贝沙格列净 相关的文献（医药）2026-10-13·CURRENT DIABETES REVIEWS
Gliflozin-Derived SGLT2 Inhibitors: Recent Advances and Future Perspectives in the Management of Type 2 Diabetes
Article
作者: Rout, Sudhansu Sekhar ; Saha, Abhijit ; Prusty, Biswanath
Gliflozin derivatives, a class of Sodium-Glucose Cotransporter (SGLT) inhibitors, have
emerged as effective antidiabetic agents offering notable cardiovascular and renal protection. This
class of compounds inhibits glucose reabsorption in the kidneys, thereby improving overall glycaemic
control. This review provides a comprehensive overview of gliflozin derivatives, emphasizing
their chemical characterization, safety, therapeutic efficacy, pharmacokinetic analysis, and potential
future applications, focusing on clinical trials and new developments released between
2010 and 2026. Gliflozin derivatives slow the progression of chronic kidney disease and reduce
the risk of heart failure. Some preliminary experimental evidence has reported the antibacterial activity
of canagliflozin against MRSA. The Gliflozin derivatives dapagliflozin (IC50 =1.1nM), ertugliflozin
(IC50 =0.9nM), sotagliflozin (IC50 =1.8nM), and bexagliflozin (IC50 =2.3nM), which has
core motif, 1-chloro-2-(4-alkoxy benzyl) benzene as an aglycon unit and a glycon unit bind with
SGLT2 receptor and lowered the HbA1c by 1.2%, 1.7%, 0.41% and 0.80%, respectively. Its selectivity,
pharmacokinetics, and toxicity profiles are also optimal. Recent studies have demonstrated
their involvement in conditions other than diabetes, including obesity, non-alcoholic fatty liver disease,
Cardioprotective, Nephroprotective, Anti-inflammatory, and antihypertensive effects. Gliflozin
derivatives represent a paradigm shift in the management of diabetes and have broad therapeutic
potential. Future studies should emphasize creative structural changes to increase safety
and efficacy.
2026-09-01·JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
Bexagliflozin controls hyperinsulinemia in horses with naturally occurring insulin dysregulation: a placebo-controlled crossover trial
Article
作者: Luethy, Daniela ; Skelton, Georgia ; Stefanovski, Darko ; van Eps, Andrew W. ; Kulp, Jeaneen ; Lowndes, Caitrin R.
Abstract:
Objective:
To evaluate bexagliflozin for insulin control in horses with naturally occurring insulin dysregulation.
Methods:
In a randomized, placebo-controlled crossover study, 10 client-owned Arabian horses with hyperinsulinemia (> 30 μIU/mL) were treated with bexagliflozin (0.03 mg/kg, PO, q 24 h; BEXA03) or placebo control for a 10-day treatment period, crossing over after a 4-day washout. After a further 12-day washout, 8 of the horses were treated with bexagliflozin (0.06 mg/kg, PO, q 24 h; BEXA06) for an additional 7-day treatment period. Oral sugar tests were performed at the beginning of each treatment period (untreated control) and on the final day of each treatment course. Insulin, glucose, triglycerides, and adipokines were compared with mixed-effects linear regression.
Results:
Mean resting, maximal (C
max
), and area under the curve (AUC) insulin were lower after BEXA06 (resting, 17.6 μIU/mL [95% CI, 5.3 to 29.9 μIU/mL]; C
max
, 48.4 μIU/mL [95% CI, 24.0 to 72.8 μIU/mL]; AUC, 4,084.0 μIU/mL*min [95% CI, 1,944.4 to 6,223.5 μIU/mL*min]) compared to placebo control (resting, 53.9 μIU/mL [95% CI, 35.0 to 72.7 μIU/mL]; C
max
, 90.9 μIU/mL [95% CI, 65.0 to 116.9 μIU/mL]; AUC, 9,146.3 μIU/mL*min [95% CI, 6,428.9 to 11,863.7 μIU/mL*min]), but not after BEXA03. Mild hypertriglyceridemia was observed in some horses following treatment with BEXA06 (n = 5), but mean resting triglyceride concentrations were not significantly higher for BEXA06 (49 mg/dL; 95% CI, 30 to 67 mg/dL) compared to the untreated control (32 mg/dL; 95% CI, 26 to 38 mg/dL).
Conclusions:
Bexagliflozin (0.06 mg/kg, PO, q 24 h) controlled insulin with minimal impact on serum triglycerides in Arabian horses with naturally occurring insulin dysregulation.
Clinical Relevance:
Treatment with bexagliflozin was effective for the short-term management of naturally occurring insulin dysregulation in horses.
2026-09-01·JOURNAL OF VETERINARY INTERNAL MEDICINE
Post-marketing safety monitoring of sodium-glucose cotransporter 2 inhibitors for diabetes in cats: a pharmacovigilance study based on the FDA ADAE database
Article
作者: Huang, Yaping ; Cheng, Yu ; Lai, Xiaoheng ; Chen, Maohua
Abstract:
Background:
Bexagliflozin and velagliflozin are currently the only sodium-glucose cotransporter 2 inhibitors approved by the United States Food and Drug Administration (FDA) for treating diabetes in cats. There are limited real-world safety reports on their associated adverse events (AEs).
Hypothesis/Objectives:
To analyze AEs associated with bexagliflozin and velagliflozin using real-world data from the FDA Animal Drug Adverse Events (ADAE) database.
Animals:
None.
Methods:
AE reports submitted for cats receiving bexagliflozin and velagliflozin. Data were obtained from the ADAE database up to the second quarter of 2025. Disproportionality analysis was conducted employing four algorithms: the reporting odds ratio (ROR), proportional reporting ratio, Bayesian confidence propagation neural network, and multi-item gamma Poisson shrinker.
Results:
Of the 34 187 AE reports for cats, 2876 were related to bexagliflozin and 2776 to velagliflozin. AEs associated with bexagliflozin spanned 22 system organ classes (SOCs), with stronger signals observed for weight fluctuation, glucosuria, and diabetic ketoacidosis. Velagliflozin-related AEs occurred in 19 SOCs, with higher RORs for ketonuria, hypochloremia, and acid–base disorders. Bexagliflozin was associated with stronger signals for DKA and ketosis, whereas velagliflozin showed stronger signals for ketonuria and hypochloremia. Velagliflozin-related AEs occurred earlier (median onset: 5 vs. 9 days), resolved more quickly (median duration: 8 vs. 14 days).
Conclusions and clinical importance:
This study provides a comprehensive safety profile of bexagliflozin and velagliflozin for diabetes in cats. These findings support veterinarians in implementing differentiated risk monitoring and individualized therapeutic decisions in the management of diabetes in cats.
117
项与 贝沙格列净 相关的新闻（医药）2026-10-15
*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放
截至10月15日15点59分，近期共有 569 本期刊发布了 1113 篇文章，其中糖尿病相关的文章共 289 篇，覆盖 40 个领域的内容。中国专家参与发表的文章有 72 篇。今日，影响因子最高的文章刊登在 The New England Journal of Medicine (IF: 78.500) 期刊上。
今日头条
Headlines
01 Journal of diabetes research IF: 03.400 韩国家庭共餐与无糖尿病成人糖尿病前期的关联研究
Eun-Ji Jung, Jae Hyeok Lim, Kui Son Choi, Min Jin Ha, Eun-Cheol Park, etc.
糖尿病前期是一种可逆转但常被忽视的疾病状态，是早期干预的关键窗口。家庭共餐行为可能有助于该阶段的疾病管理。本研究旨在探讨韩国家庭共餐行为与成人糖尿病前期患病率之间的关联。
研究分析了2019年至2023年韩国国民健康与营养调查的数据。家庭共餐被定义为每周至少三次与家人共享至少一餐（早餐、午餐或晚餐）。糖尿病前期定义为空腹血糖100-125 mg/dL或糖化血红蛋白（HbA1c）5.7%-6.4%。研究采用性别分层多变量logistic回归分析，并校正了协变量。
研究共纳入16,957名无糖尿病的成人，其中男性6,907名，女性10,050名。糖尿病前期患病率在男性中为49.1%，在女性中为42.3%。参与家庭共餐的男性相比不参与的男性，糖尿病前期风险降低16%（比值比[OR]：0.84，95%置信区间[CI]：0.73-0.97）。而在女性中，这种相关性不显著（OR：0.97，95% CI：0.84-1.11）。在男性中，这种相关性在城市居住、较高家庭收入、较高教育水平、白领职业和已婚状态的社会经济亚组中更为明显。
研究结论指出，定期参与家庭共餐与韩国无糖尿病成年男性较低的糖尿病前期患病率相关。这一发现可能有助于识别可从针对性生活方式干预中获益的人群亚组，以预防糖尿病。
本文由 韩玉莲 编辑
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Journal of diabetes research | Volume 2026, Issue 1
10.1155/jdr/7457214
02 Frontiers in pharmacology IF: 04.800 司美格鲁肽与利拉鲁肽的适应症特异性不良事件特征：一项FAERS比例失衡分析
Samuel A Fisch, Eitan J Neugut, Nicole Cornet, Daniela Quigee, Alfred I Neugut, Daniel E Freedberg, etc.
一项基于FDA不良事件报告系统（FAERS）的比例失衡分析，比较了司美格鲁肽和利拉鲁肽在2型糖尿病和肥胖适应症下的不良事件特征。研究分析了2021年至2025年第三季度的8,213,105份报告，最终纳入33,259份。
结果显示，司美格鲁肽和利拉鲁肽均表现出胃肠道不良事件信号。司美格鲁肽在两种适应症中均显示出胃肠道动力减慢的信号，特别是胃排空受损（2型糖尿病：ROR 8.35，95%CI 1.16-59.97；肥胖：ROR 4.01，95%CI 2.12-7.58）。利拉鲁肽则显示出更严重的胃肠道不良事件信号，包括2型糖尿病中的腹胀（ROR 1.46，95%CI 1.12-1.91）和肥胖中的胰腺炎（ROR 2.90，95%CI 1.91-4.39）。
此外，研究还发现司美格鲁肽与缺血性视神经病变（ROR 4.42，95%CI 1.41-13.87）和自杀意念（ROR 5.98，95%CI 1.24-24.19）等信号相关。与二甲双胍和奥利司他相比，GLP-1RA类药物在胃肠道动力障碍和梗阻性事件方面报告比例更高。
结论指出，司美格鲁肽和利拉鲁肽均与胃肠道动力减慢相关，但司美格鲁肽的胃肠道不良事件报告更多，而利拉鲁肽的胰腺炎和肝损伤报告更多。缺血性视神经病变和自杀意念等信号需谨慎解读，未来需进一步研究因果关系。
本文由 韩玉莲 编辑
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Frontiers in pharmacology | Volume 17, Issue
10.3389/fphar.2026.1936967
03 Frontiers in public health IF: 03.400 归因于肥胖的糖尿病、高血压和心血管疾病的群体负担：一项在Türkiye开展的社区研究
Banu Ersoy Şen, Meltem Yılmaz, Merve Taştan, etc.
肥胖已成为全球公共卫生大流行，其患病率迅速上升，肥胖相关慢性疾病负担日益加重。尽管肥胖患病率高，但诊断率仍然较低，限制了有效的预防和管理。因此，可靠的区域特异性流行病学数据对于指导公共卫生干预和政策制定至关重要。
这项研究旨在调查Türkiye北部Amasya省社区中不同年龄和性别群体的肥胖患病率及其与慢性疾病的关联。研究纳入22,667名成人，其中50.6%为女性，平均年龄46.4±16.1岁。数据收集于2025年6月15日至7月31日期间在实地摊位进行。身高和体重采用标准化程序测量，慢性疾病为自我报告。采用年龄和性别校正的逻辑回归评估肥胖与糖尿病、高血压和心血管疾病的相关性，并进行交互分析，同时计算归因指标。
结果显示，肥胖患病率为29.9%，女性高于男性（35.7% vs. 23.9%）。糖尿病、高血压和心血管疾病的患病率分别为12.1%、16.2%和6.6%，在肥胖个体中显著高于非肥胖个体。校正年龄和性别后，肥胖与糖尿病（aOR=2.88，95% CI 2.65-3.14）、高血压（aOR=2.50，95% CI 2.31-2.70）和心血管疾病（aOR=2.29，95% CI 2.05-2.56）的较高风险相关。肥胖的校正后人群归因分数分别为：糖尿病31.5%、高血压25.8%、心血管疾病26.1%。年龄显著修饰肥胖与所有三种慢性疾病的关联，而未观察到与性别的显著交互作用。
这项基于社区的研究表明，肥胖高度流行，且与糖尿病、高血压和心血管疾病强相关。这些疾病在群体水平上可归因于肥胖的负担巨大，进一步凸显了肥胖作为重大公共卫生问题的重要性。研究结果支持加强基于证据的策略，通过生活方式改变和基于人群的预防方法来促进健康体重。
本文由 韩玉莲 编辑
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Frontiers in public health | Volume 14, Issue
10.3389/fpubh.2026.1963530
04 Frontiers in nutrition IF: 05.100 中国南方儿童肥胖严重程度相关的多维因素：一项横断面研究
Peifeng Zhuang, Bin Lin, Haiqing Li, Jinlu Zheng, Wenlin Tang, Wenbin Ye, etc.
儿童肥胖已成为全球重大公共卫生挑战。2020年全球约有3890万（5.7%）5岁以下儿童受其影响，对儿童身体、心理及代谢健康产生长期影响。然而，关于饮食、行为、家庭及社会经济等多维度可改变因素与儿童肥胖严重程度之间分级关联的证据仍然有限，尤其是在中国东南部地区。
为此，研究人员在中国福建省开展了一项横断面研究，纳入680名学龄儿童（344名男孩和336名女孩，年龄6~16岁）。研究收集了围产期因素、家族体重状况、父母教育水平、膳食摄入、体力活动及睡眠行为等数据，并依据中国国家标准将肥胖严重程度分为四个有序组别，采用有序logistic回归模型估计关联。
研究结果显示，出生体重和婴儿喂养方式与肥胖严重程度无显著关联。母亲照护与女孩较低的肥胖风险相关。家族聚集性显著：父亲肥胖（OR 1.93，95% CI 1.20-3.06）和兄弟姐妹肥胖（OR 2.26，95% CI 1.16-4.29）与儿童肥胖风险显著正相关。父母教育水平越低，儿童肥胖严重程度越高。
在饮食行为方面，早餐频率随肥胖严重程度增加而逐渐下降。午餐和晚餐中，禽肉、海鲜、蔬菜、水果和豆类的摄入量在各组间显著减少。午餐禽肉摄入与较低肥胖风险显著相关（OR 0.558，95% CI 0.354-0.878）。烧烤、冷饮和膨化食品与肥胖风险增加相关（OR 1.763，95% CI 1.096-2.836）。相比之下，坚果（OR 0.477，95% CI 0.282-0.807）和饼干（OR 0.483，95% CI 0.322-0.723）与较低风险显著相关。
在体力活动方面，球类运动（OR 0.457，95% CI 0.227-0.918）和步行（OR 0.368，95% CI 0.180-0.751）与较低肥胖风险显著相关。较晚的就寝时间和较短的睡眠时长与肥胖严重程度相关。
研究结论指出，儿童肥胖严重程度与多种因素相关，包括家族体重状况、父母教育水平、膳食多样性、零食模式、体力活动及睡眠行为。这些发现可为以家庭为中心的多层面儿童肥胖预防策略提供参考。
本文由 韩玉莲 编辑
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Frontiers in nutrition | Volume 13, Issue
10.3389/fnut.2026.1942160
中国发表（72）
China
Journal of chromatography IF: 02.800Volume 1284, Issue No.01Integration multidimensional assessment, bioactivities and chemometrics to study the effect of different drying methods on Trichosanthis Fructus polysaccharides整合多维评估、生物活性和化学计量学方法研究不同干燥方式对瓜蒌多糖的影响DOI: 10.1016/j.jchromb.2026.125318
Trends Endocrinol Metab IF: 12.600Ahead of Print.No.02Hyocholic acid: a primary bile acid regulating lifespan immunometabolism猪胆酸：一种调节寿命免疫代谢的初级胆汁酸DOI: 10.1016/j.tem.2026.09.016
Zhonghua Wei Zhong Bing Ji Jiu Yi XueVolume 38, Issue 9No.03[Correlation between glycemic variability coefficient and sepsis-induced coagulopathy and analysis of risk factors]血糖变异系数与脓毒症诱导凝血病的相关性及危险因素分析DOI: 10.3760/cma.j.cn121430-20260331-00150
Journal of Advanced Research IF: 13.000Ahead of Print.No.04Identifying overlooked factors associated with multidrug-resistant tuberculosis: an ecological study across 201 countries and regions, 1990-2021识别与多重耐药结核病相关的被忽视因素：一项覆盖201个国家和地区、1990-2021年的生态学研究DOI: 10.1016/j.jare.2026.10.028
European journal of pharmacology IF: 04.700Ahead of Print.No.05Effects of Sitagliptin Combined with GTS-21 on Improving Glycemic Control and Diabetic Nephropathy by Anti-Apoptosis in Leprdb/db Mice西格列汀联合GTS-21通过抗凋亡改善Leprdb/db小鼠血糖控制和糖尿病肾病的作用DOI: 10.1016/j.ejphar.2026.179426
Environmental research IF: 07.700Ahead of Print.No.06Association between organophosphate esters and incident type 2 diabetes risk: modification by genetic risk and lifestyle有机磷酸酯与2型糖尿病发病风险的关联：遗传风险与生活方式的修饰作用DOI: 10.1016/j.envres.2026.125923
Diabetes Res Clin Pract IF: 07.400Ahead of Print.No.07Effectiveness of technology-enabled teleophthalmology and emerging retinal imaging techniques for diabetic retinopathy screening: a systematic review and meta-analysis技术赋能的远程眼科和新兴视网膜成像技术在糖尿病视网膜病变筛查中的有效性：系统综述和荟萃分析DOI: 10.1016/j.diabres.2026.113610
Diabetes Res Clin Pract IF: 07.400Ahead of Print.No.08Dapagliflozin and 54-week kidney function in kidney transplant recipients with post-transplant diabetes mellitus: a randomized controlled trial达格列净与肾移植受者移植后糖尿病54周肾功能：一项随机对照试验DOI: 10.1016/j.diabres.2026.113605
Journal of ethnopharmacology IF: 05.400Ahead of Print.No.09Discovery of the mechanism of Huangqi Guizhi Wuwu Decoction in the treatment of Diabetic Peripheral Neuropathy with Qi Deficiency and Blood Stasis based on the dynamic metabolic trajectory analysis基于动态代谢轨迹分析发现黄芪桂枝五物汤治疗气虚血瘀型糖尿病周围神经病变的作用机制DOI: 10.1016/j.jep.2026.122422
Journal of ethnopharmacology IF: 05.400Ahead of Print.No.10Agriophyllum squarrosum oligosaccharides ameliorate inflammation and lipid accumulation in T2DM-induced MASLD via miR-155-regulated PPARγ signaling pathways沙蓬寡糖通过miR-155调控的PPARγ信号通路改善T2DM诱导的MASLD中的炎症和脂质积累DOI: 10.1016/j.jep.2026.122462
Patient education and counseling IF: 03.100Ahead of Print.No.11Exploring doctor-patient communication in glaucoma care: A systematic review探索青光眼诊疗中的医患沟通：一项系统性综述DOI: 10.1016/j.pec.2026.110333
Clinics IF: 02.400Ahead of Print.No.12Earlier onset of type 2 diabetes mellitus as a risk factor for Irvine-Gass syndrome早发2型糖尿病是Irvine-Gass综合征的风险因素DOI: 10.1016/j.clinsp.2026.101204
Comput Med Imaging Graph IF: 04.900Ahead of Print.No.13De-Seg: Advancing OCTA segmentation with multi-scale feature fusion and edge refinementDe-Seg：通过多尺度特征融合和边缘细化推进OCTA分割DOI: 10.1016/j.compmedimag.2026.102825
Comput Biol Chem IF: 03.100Ahead of Print.No.14Integrated expression profiling and structure-based drug discovery identify EGFR as a druggable target and Tripterygium wilfordii phytochemicals as potential therapeutics for autosomal dominant polycystic kidney disease整合表达谱分析与基于结构的药物发现确定EGFR为可成药靶点及雷公藤植物化学物作为常染色体显性多囊肾病的潜在治疗药物DOI: 10.1016/j.compbiolchem.2026.109477
J Biol Chem IF: 03.900Ahead of Print.No.15An m7G tRNA-derived fragment mediated thermogenic activation of brown adipose tissue through post-transcriptional repression of Uqcr10m7G tRNA衍生片段通过转录后抑制Uqcr10介导棕色脂肪组织的产热激活DOI: 10.1016/j.jbc.2026.113640
JHEP reports IF: 07.500Ahead of Print.No.16Spleen stiffness to rule out high-risk varices in advanced chronic liver disease: an individual patient data meta-analysis脾脏硬度用于排除晚期慢性肝病高危静脉曲张：一项个体患者数据荟萃分析DOI: 10.1016/j.jhepr.2026.102066
Current neuropharmacology IF: 05.300Ahead of Print.No.17From Clinical Manifestations to Neural Mechanisms: A Systematic Review of Neurobehavioral Consequences of Pregabalin Misuse and Abuse从临床表现到神经机制：普瑞巴林误用和滥用的神经行为后果的系统综述DOI: 10.2174/011570159X512277260929095531
Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.18Cross-sectional associations of insulin resistance surrogate indices with cognitive disorders and cognitive performance in UK Biobank英国生物样本库中胰岛素抵抗替代指标与认知障碍及认知表现的横断面关联DOI: 10.1177/13872877261494125
Frontiers in nutrition IF: 05.100Volume 13, Issue No.19Correction: Enteral nutrition-related hyperglycemia in critical illness: cascade conceptual model and implications for precision nursing-a systematic review更正：危重症患者肠内营养相关高血糖：级联概念模型及精准护理的意义——一项系统综述DOI: 10.3389/fnut.2026.2000172
Science translational medicine IF: 14.600Volume 18, Issue 871No.20Metabolomic aging and mortality clocks based on ensemble learning identify systemic aging risk across the human life span in 18,476 individuals基于集成学习的代谢组衰老和死亡时钟在18,476名个体中识别人类全生命周期的系统性衰老风险DOI: 10.1126/scitranslmed.adz4815
PloS one IF: 02.600Volume 21, Issue 10No.21Association between the hemoglobin albumin lymphocyte and platelet score and chronic kidney disease: Insights from patient data and animal models血红蛋白、白蛋白、淋巴细胞和血小板评分与慢性肾脏病的关联：来自患者数据和动物模型的见解DOI: 10.1371/journal.pone.0353085
Sleep & breathing IF: 02.000Volume 30, Issue 6No.22Nonlinear age-related differences in clinical profiles of obstructive sleep apnea: a cross-sectional study of 1,508 Chinese patients阻塞性睡眠呼吸暂停临床特征的年龄相关非线性差异：一项针对1508名中国患者的横断面研究DOI: 10.1007/s11325-026-03836-3
Diabetologia IF: 10.200Ahead of Print.No.23Glucose controls metallothionein 1 gene expression in pancreatic islets via a mechanism involving cellular metabolism, granular zinc and the zinc transporter ZnT8 in rat and mouse葡萄糖通过涉及细胞代谢、颗粒锌和锌转运体ZnT8的机制调控大鼠和小鼠胰岛中金属硫蛋白1基因表达DOI: 10.1007/s00125-026-06900-5
Invest Ophthalmol Vis Sci IF: 04.700Volume 67, Issue 12No.24Targeting Endoplasmic Reticulum Stress With Exogenous GDNF Promotes Diabetic Corneal Epithelial and Neural Repair via PI3K/AKT Signaling外源性GDNF通过PI3K/AKT信号通路靶向内质网应激促进糖尿病角膜上皮和神经修复DOI: 10.1167/iovs.67.12.24
Transl Vis Sci Technol IF: 02.600Volume 15, Issue 10No.25FFA-SegGPT: A Two-Stage Cross-Modal AI System to Optimize the Clinical Workflow of Diabetic Retinopathy FFA InterpretationFFA-SegGPT：一种两阶段跨模态人工智能系统，优化糖尿病视网膜病变FFA解读的临床工作流程DOI: 10.1167/tvst.15.10.16
Autism : IF: 05.600Ahead of Print.No.26Disparities in Social Determinants of Health and Health Outcomes Among Autistic Individuals Without Intellectual Disability in Middle-to-Late Adulthood无智力障碍自闭症个体中晚年的健康社会决定因素与健康结局差异DOI: 10.1177/13623613261489847
Burns and trauma IF: 09.600Volume 14, Issue No.27Hydrogel microneedles for chronic wound microenvironment remodeling: from drug delivery to intelligent treatment用于慢性伤口微环境重塑的水凝胶微针：从药物递送到智能治疗DOI: 10.1093/burnst/tkag051
Int J Gen Med IF: 02.000Volume 19, Issue No.28Exploring the Relationship Between Femoral Neck Torsion Angle and Anteversion Angle Through Three-Dimensional Reconstruction in a Fixed Coordinate System通过固定坐标系三维重建探索股骨颈扭转角与前倾角的关系DOI: 10.2147/IJGM.S633691
Int J Gen Med IF: 02.000Volume 19, Issue No.29Recent Advances in the Diagnosis and Management of Gestational Diabetes Mellitus: A Narrative Review妊娠期糖尿病诊断与管理的最新进展：叙述性综述DOI: 10.2147/IJGM.S644149
Diabetes IF: 07.500Ahead of Print.No.30Skeletal Muscle DPT Ameliorates Obesity and Metabolic Dysfunction via the PERK/eIF2α/ATF4-GDF15 Axis骨骼肌DPT通过PERK/eIF2α/ATF4-GDF15轴改善肥胖和代谢功能障碍DOI: 10.2337/db26-0082
Adipocyte IF: 03.100Volume 15, Issue 1No.31The pro-obesity role of G3BP1 through altering adipogenic differentiation in mice via the PI3K/AKT pathwayG3BP1通过PI3K/AKT通路改变小鼠脂肪生成分化促进肥胖的作用DOI: 10.1080/21623945.2026.2743441
Current cancer drug targets IF: 03.500Ahead of Print.No.32Single-Cell Transcriptomics Identifies Fibroblast-Associated Transcriptional Patterns and Candidate Therapeutic Targets in the Comorbidity of Non-Small Cell Lung Cancer and Obesity单细胞转录组学识别非小细胞肺癌与肥胖共病中的成纤维细胞相关转录模式及候选治疗靶点DOI: 10.2174/0115680096497180260909094944
J Pediatr Gastroenterol Nutr IF: 02.600Ahead of Print.No.33The relationship between gut microbiota-friendly diet and the prevalence and severity of asthma in children肠道微生物群友好饮食与儿童哮喘患病率及严重程度的关系DOI: 10.1002/jpn3.70605
Advanced healthcare materials IF: 09.600Ahead of Print.No.34A Bioinspired Nanomedicine for Thermo-Catalytic Reprogramming of Obese Fat一种用于肥胖脂肪热催化重编程的仿生纳米药物DOI: 10.1002/adhm.71832
Frontiers in nutrition IF: 05.100Volume 13, Issue No.35Obesity and thyroid cancer: mechanisms and clinical implications肥胖与甲状腺癌：机制与临床意义DOI: 10.3389/fnut.2026.1887761
Food science & nutrition IF: 03.800Volume 14, Issue 10No.36Maternal Diglyceride Diet Attenuates Selected Metabolic Effects of Maternal High-Fat Feeding in Offspring via Energy Metabolism and Microbiota Modulation母体甘油二酯饮食通过能量代谢和微生物群调节减轻母体高脂喂养对子代的代谢影响DOI: 10.1002/fsn3.72427
Int J Endocrinol IF: 02.300Volume 2026, Issue No.37Link Between the Cardiometabolic Index and Stroke Risk Across Different Glucose Metabolic Status in Chinese Middle-Aged and Older Adults: A Longitudinal Cohort Study中国中老年人群心脏代谢指数与卒中风险的关联：不同糖代谢状态下的纵向队列研究DOI: 10.1155/ije/6169486
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.38Associations Between Multidimensional Obesity Indices and Diabetic Peripheral Neuropathy and Comparison of Their Discriminative Performance多维肥胖指标与糖尿病周围神经病变的关联及其判别性能比较DOI: 10.2147/DMSO.S634272
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.39Corneal endothelial changes in type 2 diabetes mellitus: a systematic review and meta-analysis with subgroup comparisons by diabetic retinopathy status and disease duration2型糖尿病的角膜内皮变化：按糖尿病视网膜病变状态和病程进行亚组比较的系统综述与荟萃分析DOI: 10.3389/fendo.2026.1982467
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.40Prevalence and risk factors of postmenopausal osteoporosis: a systematic review and meta-analysis based on multivariate logistic regression绝经后骨质疏松症的患病率及危险因素：基于多因素logistic回归的系统评价与meta分析DOI: 10.3389/fendo.2026.1950298
Frontiers in immunology IF: 05.900Volume 17, Issue No.41Diet, hormones, and breast cancer: biomarker-guided assessment of risk and prognosis饮食、激素与乳腺癌：生物标志物引导的风险与预后评估DOI: 10.3389/fimmu.2026.1946846
FCVM IF: 02.900Volume 13, Issue No.42Association between insulin resistance-related indices and cardiovascular disease in patients with atopic dermatitis: mutual validation using real-world and NHANES data胰岛素抵抗相关指数与特应性皮炎患者心血管疾病之间的关联：基于真实世界与NHANES数据的相互验证DOI: 10.3389/fcvm.2026.1903179
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.43Acute glycemic responses to meal-associated alcoholic beverages and ethanol in adults with type 2 diabetes: a systematic review2型糖尿病成人餐时饮用酒精饮料和乙醇的急性血糖反应：一项系统综述DOI: 10.3389/fendo.2026.1967515
Iran J Pharm Res IF: 01.800Volume 25, Issue 1No.44Yishen Xiaoke Formula Delays Renal Fibrosis in Rats with Diabetic Nephropathy by Suppressing the Transforming Growth Factor-Beta 1/Notch Signalling Pathway益肾消渴方通过抑制转化生长因子-β1/Notch信号通路延缓糖尿病肾病大鼠肾脏纤维化DOI: 10.5812/ijpr-171242
Frontiers in fungal biologyVolume 7, Issue No.45Case report: Fatal hematogenous gastrosplenic mucormycosis in an immunocompetent adult following sigmoid perforation, septic shock, and short-term stress glucocorticoids病例报告：免疫健全成人继发于乙状结肠穿孔、脓毒性休克及短期应激性糖皮质激素后的致死性血源性胃脾毛霉病DOI: 10.3389/ffunb.2026.1940494
Frontiers in immunology IF: 05.900Volume 17, Issue No.46X-linked hyper IgM syndrome with a novel CD40-ligand gene mutation suffered from infection of Talaromyces marneffeiX连锁高IgM综合征伴新型CD40配体基因突变患者感染马尔尼菲篮状菌DOI: 10.3389/fimmu.2026.1875082
Frontiers in medicine IF: 03.000Volume 13, Issue No.47Night-to-night sleep variability and all-cause and cardiovascular mortality: a prospective cohort study with a complementary in vitro circadian-disruption experiment夜间睡眠变异性与全因及心血管死亡：一项前瞻性队列研究及补充性体外昼夜节律紊乱实验DOI: 10.3389/fmed.2026.1917205
Frontiers in medicine IF: 03.000Volume 13, Issue No.48Development and validation of a novel metabolic-inflammatory health-related nomogram for predicting in-hospital mortality in older patients with type 2 diabetes mellitus combined with cardiovascular disease新型代谢-炎症健康相关列线图的开发与验证：用于预测老年2型糖尿病合并心血管疾病患者的院内死亡率DOI: 10.3389/fmed.2026.1914467
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.49CFTR variant-associated hereditary pancreatitis complicated by diabetes mellitus: a case report and literature reviewCFTR变异相关遗传性胰腺炎合并糖尿病：一例病例报告及文献综述DOI: 10.3389/fendo.2026.1907178
AME case reports IF: 00.700Volume 10, Issue No.50Classical Hodgkin lymphoma as a second malignancy in a patient with cervical squamous cell carcinoma following chemoradiotherapy: a case report宫颈鳞状细胞癌患者放化疗后发生经典霍奇金淋巴瘤作为第二恶性肿瘤：一例病例报告DOI: 10.21037/acr-2026-0174
Curēus IF: 01.300Volume 18, Issue 9No.51Association Between Left Atrial Volume Index (LAVI) and Glycemic Control (HbA1c) in Patients With Atrial Fibrillation and Type 2 Diabetes Mellitus左心房容积指数与血糖控制在心房颤动合并2型糖尿病患者中的关联DOI: 10.7759/cureus.116179
Frontiers in microbiology IF: 04.500Volume 17, Issue No.52A compartment-resolved framework for microbial sulfur-reactive sulfur signaling in diabetic cardiomyopathy: from gut metabolism to cardiac sulfur responses糖尿病心肌病中微生物硫-反应性硫信号传导的区室解析框架：从肠道代谢到心脏硫响应DOI: 10.3389/fmicb.2026.1966245
J Diabetes Metab Disord IF: 01.600Volume 25, Issue 2No.53The pharmacotherapy for pediatric obesity: insights and challenges from adult weight-loss medications儿童肥胖的药物治疗：来自成人减肥药物的启示与挑战DOI: 10.1007/s40200-026-02110-3
J Diabetes Metab Disord IF: 01.600Volume 25, Issue 2No.54Modulating inflammatory cytokines through acupuncture: Evidence from a systematic review通过针灸调节炎症细胞因子：来自系统综述的证据DOI: 10.1007/s40200-026-02098-w
Frontiers in medicine IF: 03.000Volume 13, Issue No.55Respiratory event duration reveals novel phenotypes beyond the apnea-hypopnea index in obstructive sleep apnea呼吸事件持续时间揭示阻塞性睡眠呼吸暂停中超越呼吸暂停低通气指数的新型表型DOI: 10.3389/fmed.2026.1960647
Frontiers in public health IF: 03.400Volume 14, Issue No.56The associations between dynapenic obesity and cognitive disorder in older hypertension patients: a multicenter cross-sectional study老年高血压患者肌少性肥胖与认知障碍的关联：一项多中心横断面研究DOI: 10.3389/fpubh.2026.1893791
Frontiers in nutrition IF: 05.100Volume 13, Issue No.57Multidimensional factors associated with childhood obesity severity in southern China: a cross-sectional study中国南方儿童肥胖严重程度相关的多维因素：一项横断面研究DOI: 10.3389/fnut.2026.1942160
Acta diabetologica IF: 02.900Ahead of Print.No.58Aldosterone–mineralocorticoid receptor signaling and residual cardiorenal risk in type 2 diabetes醛固酮-盐皮质激素受体信号与2型糖尿病残余心肾风险DOI: 10.1007/s00592-026-02811-4
J Transl Med IF: 07.500Volume 24, Issue 1No.59NRF2 activation attenuates obesity-induced adipose inflammation by suppressing STING signaling, with depot-specific regulationNRF2激活通过抑制STING信号减轻肥胖诱导的脂肪炎症，并具有脂肪库特异性调控DOI: 10.1186/s12967-026-08887-4
J Cell Mol Med IF: 04.200Volume 30, Issue 20No.60Application of Panax notoginseng Saponins in Skin Wound Repair: Mechanisms and Research Progress三七总皂苷在皮肤创面修复中的应用：机制与研究进展DOI: 10.1111/jcmm.71381
CCI IF: 01.900Ahead of Print.No.61The Impact of Dual Antiplatelet Therapy on Bleeding and Thrombotic Risks in Diabetic Patients Following Coronary Stent Implantation: A Prospective Study双联抗血小板治疗对冠状动脉支架植入术后糖尿病患者出血与血栓风险的影响：一项前瞻性研究DOI: 10.1002/ccd.70940
European journal of pain IF: 03.400Volume 30, Issue 9No.62Veratramine Alleviates Neuropathic Pain in Male Rats With Chronic Constriction Injury and Inhibits the PI3K/Akt Pathway藜芦胺缓解慢性压迫性损伤雄性大鼠的神经病理性疼痛并抑制PI3K/Akt通路DOI: 10.1002/ejp.70383
J Ocul Pharmacol Ther IF: 02.100Ahead of Print.No.63Ocular Distribution and Metabolite Profiling of Vorolanib in Rats and Its In Vitro Metabolism Using Human Recombinant Enzymes伏罗尼布在大鼠眼部分布及代谢物谱及其利用人重组酶的体外代谢研究DOI: 10.1177/10807683261496831
Biomed Environ Sci IF: 04.100Volume 39, Issue 9No.64Associations of the Triglyceride-glucose Index and Its Obesity-related Indices with Microvascular Complications among Individuals with Type 2 Diabetes: A Prospective Cohort Study甘油三酯-葡萄糖指数及其肥胖相关指数与2型糖尿病患者微血管并发症的关联：一项前瞻性队列研究DOI: 10.3967/bes2026.098
Biomed Environ Sci IF: 04.100Volume 39, Issue 9No.65Dietary Live Microbe Intake and Sarcopenia in Shanghai上海地区膳食活性微生物摄入与肌肉减少症的关联研究DOI: 10.3967/bes2026.095
Biomed Environ Sci IF: 04.100Volume 39, Issue 9No.66A Nationwide Cross-Sectional Study of Chronic Urticaria in Chinese Adults with Cardiometabolic Diseases: Epidemiology, Risk Factors, and Effect on Disease Management中国成人慢性荨麻疹合并心血管代谢疾病的全国横断面研究：流行病学、危险因素及对疾病管理的影响DOI: 10.3967/bes2026.084
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.67Transition-Specific Associations of Cardiometabolic Biomarker Burden With Cardio-Renal-Metabolic Multimorbidity Progression: A Multistate Cohort Study心血管代谢生物标志物负担与心血管-肾脏-代谢多病进展的转变特异性关联：一项多状态队列研究DOI: 10.1111/dom.71427
Advanced healthcare materials IF: 09.600Ahead of Print.No.68Immune‑Friendly Skin Interface Remodeling: Chiral Hydrogels for Diabetic Non-Healing Wound Therapy免疫友好型皮肤界面重塑：手性水凝胶用于糖尿病非愈合性创面治疗DOI: 10.1002/adhm.71842
Nature communications IF: 15.700Volume 17, Issue 1No.69PKM2 AP: a micropeptide inhibits vascular calcification via molecular glue-mediated ubiquitination of PKM2PKM2 AP：一种通过分子胶介导的PKM2泛素化抑制血管钙化的微肽DOI: 10.1038/s41467-026-77693-9
Signal Transduct Target Ther IF: 52.700Volume 11, Issue 1No.70Rhein-induced free fatty acid generation cooperates with silver ions for biofilm-infected diabetic wound healing大黄酸诱导游离脂肪酸生成与银离子协同促进生物膜感染的糖尿病伤口愈合DOI: 10.1038/s41392-026-02869-0
Clinical pharmacokinetics IF: 04.000Ahead of Print.No.71Efsubaglutide Alfa: A Comprehensive Pharmacological Review依苏帕格鲁肽α：综合药理学综述DOI: 10.1007/s40262-026-01713-6
Journal of molecular histology IF: 02.200Volume 57, Issue 6No.72Liraglutide ameliorates obese type 2 diabetes by regulating macrophage cholesterol metabolism and H3K27ac modification to promote M2 polarization and adipocyte thermogenic activation利拉鲁肽通过调控巨噬细胞胆固醇代谢和H3K27ac修饰促进M2极化和脂肪细胞产热激活改善肥胖型2型糖尿病DOI: 10.1007/s10735-026-10993-y
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Gynecologic oncology IF: 04.100Ahead of Print.No.02Effects of adjunctive metformin on recurrence-free survival and reproductive outcomes following progestin-based fertility-sparing treatment for endometrial neoplasia: Results from the FELICIA trial, a prospective, randomized, phase IIb trial with blinded central adjudicationDOI: 10.1016/j.ygyno.2026.10.004
The journal of neuroscience : IF: 04.000Volume 46, Issue 41No.03Corticotropin-Releasing Hormone Differentially Modulates GABA and Non-GABA Nucleus Tractus Solitarii Neurons促肾上腺皮质激素释放激素对孤束核GABA与非GABA神经元发挥差异性调控作用DOI: 10.1523/JNEUROSCI.0525-26.2026
Pain medicine case reportsVolume 10, Issue 7No.04Peripheral Nerve Stimulator Implant for Superior Cluneal Neuralgia in Patients with Peripheral Neuropathy: A Case Series周围神经刺激器植入治疗周围神经病患者的上臀神经痛：病例系列https://pubmed.ncbi.nlm.nih.gov/42874086
J Biol Chem IF: 03.900Ahead of Print.No.05ERK-mediated phosphorylation modulates the autolytic processing of the cysteine protease CAPN3ERK介导的磷酸化调节半胱氨酸蛋白酶CAPN3的自溶加工DOI: 10.1016/j.jbc.2026.113638
Biochem Biophys Res Commun IF: 02.200Ahead of Print.No.06Efonidipine inhibiting CYP4A attenuates palmitate-induced hepatocyte lipotoxicity依福地平抑制CYP4A减轻棕榈酸诱导的肝细胞脂毒性DOI: 10.1016/j.bbrc.2026.154723
Res Social Adm Pharm IF: 02.800Ahead of Print.No.07Pharmacists and Ramadan: From education to practice - A mixed methods systematic review药师与斋月：从教育到实践——一项混合方法系统综述DOI: 10.1016/j.sapharm.2026.10.150
Transplantation proceedings IF: 00.800Ahead of Print.No.08Profound Tacrolimus-Induced Catatonic Encephalopathy in a Kidney Transplant Recipient With Mitochondrial Myopathy: A Cautionary Case of Reversible Neurotoxicity线粒体肌病肾移植受者中他克莫司诱导的严重紧张症性脑病：一例可逆性神经毒性的警示病例DOI: 10.1016/j.transproceed.2026.09.022
Diabetic medicine IF: 03.400Ahead of Print.No.09The DePICtion study: Implementing a diabetes classification tool in UK primary care-A qualitative study with primary care staff and patientsDePICtion研究：在英国初级保健中实施糖尿病分类工具——一项针对初级保健工作人员和患者的定性研究DOI: 10.1111/dme.70493
J Atheroscler Thromb IF: 02.800Ahead of Print.No.10Associations of Albuminuria and eGFR with Stiffness Parameter β in Type 2 Diabetes2型糖尿病患者白蛋白尿与估算肾小球滤过率同僵硬度参数β的关联DOI: 10.5551/jat.66371
Endocrine journal IF: 02.100Ahead of Print.No.11Metreleptin improves glucose metabolism and hepatic steatosis in a patient with Werner syndrome and partial lipodystrophy: a case report with review of literature美曲普汀改善Werner综合征合并部分性脂肪萎缩患者的糖代谢和肝脂肪变性：一例病例报告及文献综述DOI: 10.1507/endocrj.EJ26-0235
Diabetic medicine IF: 03.400Ahead of Print.No.12Capability, opportunity and motivation to support adults with type 1 diabetes experiencing fear of hypoglycaemia: A survey of Australian diabetes healthcare professionals支持经历低血糖恐惧的成人1型糖尿病患者的能力、机会和动机：一项针对澳大利亚糖尿病医疗专业人员的调查DOI: 10.1111/dme.70496
Internal medicine IF: 01.100Ahead of Print.No.13Ampullary Neuroendocrine Carcinoma Presenting with Clinically Confirmed Endogenous Hyperinsulinemic Hypoglycemia以临床确诊的内源性高胰岛素性低血糖为表现的壶腹部神经内分泌癌DOI: 10.2169/internalmedicine.7605-26
Diabetic medicine IF: 03.400Ahead of Print.No.14The impact of frailty on glycaemic control in older adults with type 1 diabetes mellitus: An observational study衰弱对老年1型糖尿病患者血糖控制的影响：一项观察性研究DOI: 10.1111/dme.70498
Diabetic medicine IF: 03.400Ahead of Print.No.15Estimating the long-term cost-effectiveness of a free online Diabetes Self-Management Education and Support service in England: Healthy living for people with type 2 diabetes, using a matched cohort study design基于匹配队列研究设计评估英格兰免费在线糖尿病自我管理教育与支持服务的长期成本效果：针对2型糖尿病患者的健康生活项目DOI: 10.1111/dme.70490
BMJ case reports IF: 00.500Volume 19, Issue 10No.16Diabetic ketoacidosis in a patient with renal cell carcinoma on immune checkpoint inhibitor接受免疫检查点抑制剂治疗的肾细胞癌患者发生糖尿病酮症酸中毒DOI: 10.1136/bcr-2025-268141
Enfermeri?a cli?nicaAhead of Print.No.17The role of nurses in shared decision-making in primary care: Qualitative study护士在初级保健共享决策中的作用：定性研究DOI: 10.1016/j.enfcle.2026.502562
Journal of Advanced Research IF: 13.000Ahead of Print.No.18Association between dental pulp necroptosis-related signaling and elodont incisor growth retardation in hyperglycemic rats高血糖大鼠牙髓坏死性凋亡相关信号与持续生长切牙生长迟缓的关联DOI: 10.1016/j.jare.2026.10.027
Appetite IF: 03.800Ahead of Print.No.19Neuroimaging Insights into the Effects of Non-Nutritive Sweeteners on Appetite Regulation: A Systematic Review非营养性甜味剂对食欲调节影响的神经影像学见解：一项系统综述DOI: 10.1016/j.appet.2026.108803
Brain, behavior, and immunity IF: 07.600Ahead of Print.No.20Early post-sepsis innate behavioral changes in aged mice occur independently of detectable neuroinflammation老年小鼠脓毒症后早期先天行为改变独立于可检测的神经炎症DOI: 10.1016/j.bbi.2026.107062
Toxicol Appl Pharmacol IF: 03.400Ahead of Print.No.21High Normal dietary casein attenuates bisphenol A-induced multiorgan toxicity in rats: Preservation of renal integrity, glucose homeostasis, and immune surveillance via modulation of oxidative stress, inflammation, and apoptosis高正常膳食酪蛋白减轻双酚A诱导的大鼠多器官毒性：通过调节氧化应激、炎症和凋亡保护肾脏完整性、葡萄糖稳态和免疫监视DOI: 10.1016/j.taap.2026.118085
Annals of Vascular Surgery IF: 01.600Ahead of Print.No.22"Not so minor" - Digital Amputation as a precursor to Major Amputation and Mortality in an Irish tertiary vascular centre“并非小问题”——趾截肢作为爱尔兰三级血管中心大截肢和死亡的前兆DOI: 10.1016/j.avsg.2026.09.058
Annals of Vascular Surgery IF: 01.600Ahead of Print.No.23THE CLINICAL PROFILE OF RUPTURE: A 19-YEAR CASE-CONTROL STUDY OF ABDOMINAL AORTIC ANEURYSMS破裂的临床特征：一项为期19年的腹主动脉瘤病例对照研究DOI: 10.1016/j.avsg.2026.09.070
Complement Ther Med IF: 03.500Ahead of Print.No.24Pilot, Feasibility, and Acceptability Evaluation of a Mindfulness-Based Intervention with Diabetes Education in Adolescents with Type 1 Diabetes基于正念的干预联合糖尿病教育在1型糖尿病青少年中的试点、可行性和可接受性评估DOI: 10.1016/j.ctim.2026.103451
Diabetes Res Clin Pract IF: 07.400Ahead of Print.No.25Effects of diagnostic thresholds for gestational diabetes on perinatal mental health: Data from the GEMS randomised clinical trial妊娠糖尿病诊断阈值对围产期心理健康的影响：来自GEMS随机临床试验的数据DOI: 10.1016/j.diabres.2026.113590
Photodiagnosis Photodyn Ther IF: 02.600Ahead of Print.No.26Epivascular Glia and Macular Pigment Changes after Faricimab or Aflibercept during the Loading Phase in Diabetic Macular Edema: A Prospective Non-randomized Pilot Study糖尿病性黄斑水肿负荷期使用Faricimab或Aflibercept后血管周围胶质细胞和黃斑色素变化：一项前瞻性非随机初步研究DOI: 10.1016/j.pdpdt.2026.105687
Cornea IF: 02.100Ahead of Print.No.27The Effects of Age on the Presence of Atypical Corneal Nerve Formations年龄对非典型角膜神经结构存在的影响DOI: 10.1097/ICO.0000000000004341
Journal of tissue viability IF: 02.800Ahead of Print.No.28Findings on the efficacy of sonic debridement in chronic wound management - a case series声波清创在慢性伤口管理中的有效性研究——病例系列DOI: 10.1016/j.jtv.2026.101064
Rev Argent Microbiol IF: 02.100Ahead of Print.No.29Antimicrobial resistance and antibiotic therapy in patients with urinary tract infections and asymptomatic bacteriuria: A Peruvian perspective尿路感染与无症状性菌尿患者的抗菌药物耐药性及抗生素治疗：秘鲁视角DOI: 10.1016/j.ram.2026.100760
Clin Neurol Neurosurg IF: 01.600Ahead of Print.No.30Differentiating pituitary metastasis from hypophysitis: A two-center study using conventional MRI and clinical features鉴别垂体转移瘤与垂体炎：基于常规MRI和临床特征的双中心研究DOI: 10.1016/j.clineuro.2026.109662
Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.31Evaluation of a local healthy moderate carbohydrate (LHMC) diet and structured exercise for diabetes remission in early type 2 diabetes mellitus: A nutrition intervention study from India评估本地健康中等碳水化合物饮食与结构化运动对早期2型糖尿病缓解的作用：一项来自印度的营养干预研究DOI: 10.1016/j.dsx.2026.103487
J Pharmacol Exp Ther IF: 03.800Ahead of Print.No.32Sirtuin 1-microRNA regulatory networks in liver diseases: Mechanistic convergence, cellular senescence, and translational implications肝脏疾病中的Sirtuin 1-微小RNA调控网络：机制汇聚、细胞衰老及转化意义DOI: 10.1016/j.jpet.2026.105031
Injury IF: 02.000Ahead of Print.No.33Association of neighborhood social vulnerability with reoperation after operative treatment of proximal humerus fractures社区社会脆弱性与肱骨近端骨折手术治疗后再手术的关联DOI: 10.1016/j.injury.2026.113769
J Plast Reconstr Aesthet Surg IF: 02.400Ahead of Print.No.34GLP-1 receptor agonist use and postoperative complications after body contouring surgery following massive weight loss减重手术后身体塑形手术中GLP-1受体激动剂使用与术后并发症的关系DOI: 10.1016/j.bjps.2026.09.040
Clin Transl Sci IF: 02.800Volume 19, Issue 10No.35Analysis of Virologic and Clinical Predictors for Hospitalization, Supported by Machine Learning, in a Phase 3 Molnupiravir COVID-19 Treatment Trial在3期molnupiravir COVID-19治疗试验中，通过机器学习支持分析住院的病毒学和临床预测因素DOI: 10.1111/cts.70720
Journal of chromatography IF: 02.800Ahead of Print.No.36Development and validation of qualitative methods for the detection of GLP-1 receptor agonists in serum and dried blood spots by LC-HRMS/MS for doping control purposes用于兴奋剂检测的血清和干血斑中GLP-1受体激动剂的LC-HRMS/MS定性方法的开发与验证DOI: 10.1016/j.jchromb.2026.125326
J Matern Fetal Neonatal Med IF: 01.600Volume 39, Issue 1No.37Characterizing vaginal misoprostol induction in individuals with and without severe obesity严重肥胖与非严重肥胖个体阴道米索前列醇引产的特征分析DOI: 10.1080/14767058.2026.2744004
Surg Obes Relat Dis IF: 03.800Ahead of Print.No.38Clinical outcomes in solid organ transplant recipients undergoing Roux-en-Y gastric bypass surgery: a propensity score-matched study实体器官移植受者接受Roux-en-Y胃旁路手术的临床结局：一项倾向性评分匹配研究DOI: 10.1016/j.soard.2026.09.015
Internal medicine IF: 01.100Ahead of Print.No.39Changes in Gait Speed During a 12-Month Multidisciplinary Obesity Management Program Including Semaglutide: A Real-World Observational Study in Japanese Adults With Musculoskeletal Disorders包含司美格鲁肽的12个月多学科肥胖管理项目期间步速变化：一项针对患有肌肉骨骼疾病的日本成人的真实世界观察性研究DOI: 10.2169/internalmedicine.8145-26
J Obes Metab Syndr IF: 07.900Ahead of Print.No.40Perspectives on Community-Based Pediatric Obesity Prevention and Management Programs in South Korea: A Qualitative Interview Study of School and Local Public Health Center Providers韩国社区儿童肥胖预防与管理项目的视角：对学校和地方公共卫生中心提供者的定性访谈研究DOI: 10.7570/jomes25099
Journal of neuroendocrinology IF: 04.100Volume 38, Issue 10No.41Changes in leptin and melanocortin peptides in cerebrospinal fluid after diet versus bariatric surgery饮食与减重手术后脑脊液中瘦素和黑皮质素肽的变化DOI: 10.1111/jne.70292
Journal of applied gerontology : IF: 02.000Ahead of Print.No.42Beyond BMI: The Role of Abdominal Obesity in Hypertension Risk Among Adults Aged 45 Years and Older in India超越体重指数：腹型肥胖在印度45岁及以上成年人高血压风险中的作用DOI: 10.1177/07334648261497261
Canadian journal of diabetes IF: 02.600Ahead of Print.No.43The Causal Role of Adiponectin in Type 2 Diabetes across Ages and Sexes - An Observational and Mendelian Randomization Study脂联素在2型糖尿病中的因果作用：跨年龄和性别的观察性与孟德尔随机化研究DOI: 10.1016/j.jcjd.2026.09.010
Fish & shellfish immunology IF: 03.900Ahead of Print.No.44A c-Jun N-terminal kinase (JNK) homolog from Macrobrachium rosenbergii participates in immune defense against Aeromonas hydrophila罗氏沼虾c-Jun N末端激酶（JNK）同源物参与抗嗜水气单胞菌的免疫防御DOI: 10.1016/j.fsi.2026.111771
Diabetes Res Clin Pract IF: 07.400Ahead of Print.No.45Capturing human-machine interplay in automated insulin delivery systems through day-to-day variability of the automated correction index (ACI-V%)通过自动校正指数日间变异性（ACI-V%）捕捉自动胰岛素输送系统中的人机交互DOI: 10.1016/j.diabres.2026.113613
Reproductive toxicology IF: 02.800Ahead of Print.No.46Glycerol supplementation attenuates testicular inflammation and miRNA dysregulation in obese rats甘油补充减轻肥胖大鼠的睾丸炎症和微小RNA失调DOI: 10.1016/j.reprotox.2026.109380
Archives of medical research IF: 03.400Ahead of Print.No.47Sex-Specific Neurobehavioral Programming in Offspring by a Maternal High-Fat, Plant-Based Diet: A Central Role of the Hippocampus母体高脂植物性饮食对子代神经行为编程的性别特异性影响：海马的核心作用DOI: 10.1016/j.arcmed.2026.103530
Heart, Lung and Circulation IF: 02.200Ahead of Print.No.48Lipoprotein(a) Reporting by Australian Chemical Pathology Laboratories澳大利亚化学病理实验室的脂蛋白(a)检测报告实践DOI: 10.1016/j.hlc.2026.05.016
The Lancet Psychiatry IF: 24.800Volume 13, Issue 11, Page 905-974, e14No.49Change in HbA1c and weight after initiation of antipsychotic treatment in people with severe mental illness in England: an individual-level interrupted time-series analysis英格兰严重精神疾病患者启动抗精神病药物治疗后糖化血红蛋白和体重的变化：个体水平中断时间序列分析DOI: 10.1016/S2215-0366(26)00274-9
The Lancet Psychiatry IF: 24.800Volume 13, Issue 11, Page 905-974, e14No.50GLP-1 receptor agonist initiation and risk of psychiatric hospitalisation and emergency department presentation in adults with schizophrenia and type 2 diabetes in the USA: an observational cohort study using electronic health records dataGLP-1受体激动剂起始治疗与精神分裂症合并2型糖尿病成人患者精神科住院及急诊就诊风险：基于电子健康记录数据的观察性队列研究DOI: 10.1016/S2215-0366(26)00276-2
The Lancet Psychiatry IF: 24.800Volume 13, Issue 11, Page 905-974, e14No.51Preventing predictable harm in severe mental illness预防严重精神疾病中可预测的伤害DOI: 10.1016/S2215-0366(26)00301-9
EJPC IF: 07.500Ahead of Print.No.52Outcomes in patients with diabetes, atherosclerotic cardiovascular disease, and heart failure treated with tirzepatide or dulaglutide: SURPASS-CVOT analysis合并糖尿病、动脉粥样硬化性心血管疾病和心力衰竭患者接受替尔泊肽或度拉糖肽治疗的结果：SURPASS-CVOT分析DOI: 10.1093/eurjpc/zwag452
Cardiovascular Diabetology IF: 10.600Ahead of Print.No.53Event-anchored piecewise trajectories of the triglyceride-glucose index before and after incident cardiovascular disease: a propensity score-matched longitudinal study from the English Longitudinal Study of Ageing甘油三酯-葡萄糖指数在心血管疾病发病前后的以事件为锚点的分段轨迹：来自英国老龄化纵向研究的倾向评分匹配纵向研究DOI: 10.1186/s12933-026-03387-7
JAMA surgery IF: 14.900Ahead of Print.No.54Bariatric Surgery Is Preventive Medicine减重手术是预防医学DOI: 10.1001/jamasurg.2026.4778
NEJM IF: 78.500Ahead of Print.No.55Continuous Glucose Monitoring in Non–Insulin-Treated Type 2 Diabetes非胰岛素治疗的2型糖尿病中的持续葡萄糖监测DOI: 10.1056/NEJMoa2608571
NEJM IF: 78.500Volume 395, Issue 15No.56Adult Attention Deficit–Hyperactivity Disorder成人注意缺陷多动障碍DOI: 10.1056/NEJMcp2516040
NEJM IF: 78.500Volume 395, Issue 15No.57Setmelanotide for the Treatment of Acquired Hypothalamic ObesitySetmelanotide用于治疗获得性下丘脑性肥胖DOI: 10.1056/NEJMc2610994
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.58Identifying a high-risk CKM syndrome phenotype: association of albuminuria with subclinical hemodynamic alterations via portable noninvasive cardiometer识别高风险心血管-肾脏-代谢综合征表型：白蛋白尿与便携式无创心排量监测仪检测的亚临床血流动力学改变的关联DOI: 10.3389/fendo.2026.1966139
Journal of opioid managementVolume 22, Issue 5No.59Comparison of long-term outcomes between opioid-free and opioid-based anesthesia in head and neck cancer surgeries: A pilot study头颈癌手术中无阿片类麻醉与阿片类麻醉长期结局的比较：一项初步研究DOI: 10.5055/jom.0996
JAMA psychiatry IF: 17.100Ahead of Print.No.60Patient-Reported Changes in Alcohol Use Following Glucagon-Like Peptide-1 Receptor Agonist Initiation胰高血糖素样肽-1受体激动剂启用后患者报告的酒精使用变化DOI: 10.1001/jamapsychiatry.2026.3242
Aesthetic surgery journal / IF: 03.900Ahead of Print.No.61Glucagon-Like Peptide-1 Receptor Agonist-Associated Facial Changes: A Comprehensive Review of Pathophysiology, Clinical Manifestations, Risk Factors, Prevention, and Management胰高血糖素样肽-1受体激动剂相关的面部变化：病理生理学、临床表现、危险因素、预防和管理的综合综述DOI: 10.1093/asj/sjag230
PRiMERVolume 10, Issue No.62Glycemic Outcomes Associated With GLP-1 Receptor Agonist Shortages in Type 2 Diabetes2型糖尿病患者中GLP-1受体激动剂短缺相关的血糖结局DOI: 10.22454/PRiMER.2026.826203
Med J Islam Repub IranVolume 40, Issue No.63Mechanisms of Vestibular System Damage in Diabetes Mellitus: Implications for Benign Paroxysmal Positional Vertigo Pathogenesis and Recurrence糖尿病中前庭系统损伤的机制：对良性阵发性位置性眩晕发病机制和复发的影响DOI: 10.47176/mjiri.40.75
Plant signaling & behavior IF: 03.600Volume 21, Issue 1No.64γ-aminobutyric acid is associated with calcium, reactive oxygen species, and nitric oxide responses and enhanced cadmium tolerance in Salvadora persicaγ-氨基丁酸与钙、活性氧和一氧化氮响应相关并增强Salvadora persica的镉耐受性DOI: 10.1080/15592324.2026.2748062
AME case reports IF: 00.700Volume 10, Issue No.65Thyroid storm revealing suspected evolving autoimmune polyglandular syndrome type 2 with steroid-limited assessment of autoimmune adrenal insufficiency: a case report甲状腺危象揭示疑似进展性自身免疫性多腺体综合征2型伴类固醇限制性自身免疫性肾上腺功能不全评估：一例病例报告DOI: 10.21037/acr-2026-0181
Clinical science IF: 07.700Ahead of Print.No.66Deletion of Nephrocystin-4 Exacerbates Kidney and Cardiac Function in Mice Cardiorenal Syndrome Model via the Interaction with Itch E3 ligaseNephrocystin-4缺失通过与其Itch E3连接酶的相互作用加重小鼠心肾综合征模型中的肾脏和心脏功能DOI: 10.1042/CS20262448
J Mol Neurosci IF: 02.700Volume 76, Issue 4No.67"Morphological, Functional, and Molecular Progression of Blood-Brain Barrier Dysfunction in Alzheimer's Disease"阿尔茨海默病中血脑屏障功能障碍的形态学、功能与分子进展DOI: 10.1007/s12031-026-02610-0
Current pharmaceutical design IF: 02.800Ahead of Print.No.68Emerging Therapeutic Strategies for Graves' Disease: Current Advances and Future PerspectivesGraves病的新兴治疗策略：当前进展与未来展望DOI: 10.2174/0113816128537581261007065942
Brain : IF: 11.700Ahead of Print.No.69Biallelic variants in PIKFYVE cause a hypomyelinating leukodystrophy with endolysosomal dysfunctionPIKFYVE双等位基因变异导致伴内溶酶体功能障碍的低髓鞘性脑白质营养不良DOI: 10.1093/brain/awag355
ACS Pharmacol Transl Sci IF: 03.700Volume 9, Issue 10No.70A Human Glucoregulatory Model for the Rational Design and Evaluation of Diabetes Therapeutics用于糖尿病治疗药物理性设计与评估的人类血糖调控模型DOI: 10.1021/acsptsci.6c00356
ACS Pharmacol Transl Sci IF: 03.700Volume 9, Issue 10No.71Hepatic Overexpression of a Novel Soluble Endogenous Transforming Growth Factor β Type II Receptor-Immunoglobulin G1 Fc Fusion Protein (TβRII-SE/Fc) Attenuates Early Stage Metabolic Dysfunction-Associated Steatotic Liver Disease in Rats肝脏过表达新型可溶性内源性转化生长因子β II型受体-免疫球蛋白G1 Fc融合蛋白（TβRII-SE/Fc）减轻大鼠早期代谢功能障碍相关脂肪性肝病DOI: 10.1021/acsptsci.6c00410
ACS Pharmacol Transl Sci IF: 03.700Volume 9, Issue 10No.72Diabetes-Associated Cognitive Dysfunction: Pathophysiology, Molecular Mechanisms, and Emerging Therapeutic Strategies糖尿病相关认知功能障碍：病理生理学、分子机制与新兴治疗策略DOI: 10.1021/acsptsci.6c00440
Clin Exp Dermatol IF: 02.800Ahead of Print.No.73Prescribed insulin use in type II diabetes mellitus and skin cancer risk: A systematic review 32型糖尿病中处方胰岛素使用与皮肤癌风险：一项系统综述3DOI: 10.1093/ced/llag444
Cancer reports IF: 01.900Volume 9, Issue 10No.74Periprocedural Wound Complication Risks in Cancer Pain Patients Following Targeted Cancer Therapy: A Retrospective Analysis癌症疼痛患者接受靶向癌症治疗后的围手术期伤口并发症风险：一项回顾性分析DOI: 10.1002/cnr2.70664
J Clin Invest IF: 13.600Ahead of Print.No.75Manganese availability determines hepatic insulin sensitivity by enhancing Akt activity锰的可利用性通过增强Akt活性决定肝脏胰岛素敏感性DOI: 10.1172/JCI200951
J Clin Invest IF: 13.600Ahead of Print.No.76SGLT1/2 inhibitor sotagliflozin, but not SGLT2-selective inhibitor empagliflozin, attenuates platelet activation and thrombosisSGLT1/2抑制剂索格列净而非SGLT2选择性抑制剂恩格列净可减弱血小板活化和血栓形成DOI: 10.1172/JCI201899
Salud pública de México IF: 03.100Volume 68, Issue 5 (sept-oct)No.77[Not Available]2025年Ensanut视觉健康模块的方法学设计与范围DOI: 10.21149/18641
JIC IF: 01.400Ahead of Print.No.78Chronic total occlusion percutaneous coronary interventions in dialysis patients透析患者的慢性完全闭塞经皮冠状动脉介入治疗DOI: 10.25270/jic/26.00260
Diabetes care IF: 16.600Ahead of Print.No.79Erratum. Sodium-Glucose Cotransporter 2 Inhibitor Use and Risk of Liver-Related Events in Patients With Type 2 Diabetes: A Meta-analysis of Observational Cohort Studies. Diabetes Care 2025;48:1042-1052勘误。钠-葡萄糖协同转运蛋白2抑制剂使用与2型糖尿病患者肝脏相关事件风险：观察性队列研究的Meta分析。Diabetes Care 2025;48:1042-1052DOI: 10.2337/dc27-er01
Wounds IF: 01.100Volume 38, Issue 9No.80Prospective evaluation of the clinical effectiveness of an innovative catalytic wound care technology创新催化伤口护理技术临床有效性的前瞻性评估DOI: 10.25270/wnds/25122
PLOS pathogens IF: 04.900Ahead of Print.No.81Intranasal HSV‑1 infection drives region‑specific interferon‑dominant microglial remodeling鼻内HSV-1感染驱动区域特异性干扰素主导的小胶质细胞重塑DOI: 10.1371/journal.ppat.1014684
PloS one IF: 02.600Volume 21, Issue 10No.82Subnational spatial co-distribution of tuberculosis and diabetes mellitus across Ghana's 16 regions following administrative reorganisation: An ecological analysis行政重组后加纳16个地区结核病与糖尿病的次国家级空间共分布：一项生态学分析DOI: 10.1371/journal.pone.0354405
PloS one IF: 02.600Volume 21, Issue 10No.83Low diet quality increases the genetic risk of high blood cholesterol levels in Asian Indian adults [CURES - 165]低饮食质量增加亚洲印度成年人高血胆固醇水平的遗传风险 [CURES - 165]DOI: 10.1371/journal.pone.0357182
Gerontology : IF: 03.000Ahead of Print.No.84Local RAGE Inhibition Attenuates Early Diabetic Retinal Pathology in Streptozotocin-Induced Rats局部RAGE抑制减轻链脲佐菌素诱导大鼠的早期糖尿病视网膜病变DOI: 10.1159/ger/acxag008
J Biomol Struct Dyn IF: 02.400Ahead of Print.No.85Structure-dynamics analysis of insulin receptor modulation by plant-derived ligands suggests a potential regulatory role for Asn711植物来源配体调控胰岛素受体的结构动力学分析提示Asn711的潜在调控作用DOI: 10.1080/07391102.2026.2741934
Diabetes care IF: 16.600Ahead of Print.No.86Contemporary Sex-Specific Mortality Risk in Type 1 Diabetes During the Era of Advanced Therapeutic Care当代先进治疗护理时代1型糖尿病的性别特异性死亡风险DOI: 10.2337/dc26-1472
Journal of periodontology IF: 03.800Ahead of Print.No.87Association between xerostomia and peri-implant health: A retrospective cohort study口干症与种植体周围健康之间的关联：一项回顾性队列研究DOI: 10.1002/jper.70192
GeroScience IF: 05.400Ahead of Print.No.88Plasma biomarkers of neurodegeneration and physical performance in older adults老年人神经退行性变的血浆生物标志物与身体表现DOI: 10.1007/s11357-026-02570-8
Clin Rev Allergy Immunol IF: 11.300Volume 69, Issue 1No.89Single-cell Transcriptomics in Autoimmune Diseases: Mechanistic Insights, Cross-disease Convergence, and Translational Challenges in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Type 1 Diabetes, and Multiple Sclerosis自身免疫性疾病中的单细胞转录组学：类风湿关节炎、系统性红斑狼疮、1型糖尿病和多发性硬化中的机制见解、跨疾病趋同及转化挑战DOI: 10.1007/s12016-026-09211-0
J Cardiovasc Surg (Torino) IF: 01.500Ahead of Print.No.90Bailout stenting strategy in complex femoropopliteal lesions: mid-term outcomes with drug-eluting versus bare-metal stents复杂股腘动脉病变的补救性支架策略：药物洗脱支架与裸金属支架的中期结局DOI: 10.23736/S0021-9509.26.13592-7
JACC: Cardiovascular Imaging IF: 15.200Ahead of Print.No.91Bending the Curve: Revealing Population Risk With Quantitative Atherosclerotic Plaque扭转曲线：利用定量动脉粥样硬化斑块揭示人群风险DOI: 10.1016/j.jcmg.2026.09.002
Invest Ophthalmol Vis Sci IF: 04.700Volume 67, Issue 12No.92Neuroprotective and Anti-Inflammatory Effects of SOCS1 Mimetic Peptides in Mouse Diabetic RetinopathySOCS1模拟肽在小鼠糖尿病视网膜病变中的神经保护与抗炎作用DOI: 10.1167/iovs.67.12.21
J Diabetes Sci Technol IF: 03.700Ahead of Print.No.93Redistributing Insulin Pumps for Patients Facing Access Barriers为面临获取障碍的患者重新分配胰岛素泵DOI: 10.1177/19322968261493576
J Diabetes Sci Technol IF: 03.700Ahead of Print.No.94Effectiveness of Continuous Glucose Monitoring in Non-Intensively Managed Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials持续葡萄糖监测在非强化管理的2型糖尿病中的有效性：随机对照试验的系统评价与荟萃分析DOI: 10.1177/19322968261489265
J Diabetes Sci Technol IF: 03.700Ahead of Print.No.95From Clinician-Based Risk Score to Diabetes Complications: Validating the Glycemia Risk Index with the Virtual Diabetes Control and Complications Trial Continuous Glucose Monitoring Data从临床医生风险评分到糖尿病并发症：利用虚拟糖尿病控制与并发症试验的连续葡萄糖监测数据验证血糖风险指数DOI: 10.1177/19322968261489629
J Acquir Immune Defic Syndr IF: 02.900Ahead of Print.No.96Cross-sectional Comparison of the PREVENT and Pooled Cohort Equations for 10-Year Atherosclerotic Cardiovascular Risk Estimates in a U.S. Cohort of Black and Latina Transgender Women with HIVPREVENT与汇总队列方程在美国黑人及拉丁裔跨性别女性HIV感染者中10年动脉粥样硬化性心血管风险估计的横断面比较DOI: 10.1097/QAI.0000000000003985
J Diabetes Sci Technol IF: 03.700Ahead of Print.No.97Performance of a 15-Day Continuous Glucose Monitoring System in Children and Adolescents With Diabetes15天连续血糖监测系统在儿童和青少年糖尿病患者中的性能表现DOI: 10.1177/19322968261493981
Blood Pressure IF: 02.300Ahead of Print.No.98Epidemiology of Uncontrolled and Treatment‑Resistant Hypertension: A Registry‑Based Observational Study未控制高血压与难治性高血压的流行病学：一项基于注册的观察性研究DOI: 10.1080/08037051.2026.2749134
Curr Comput Aided Drug Des IF: 01.600Ahead of Print.No.99In silico and Network Pharmacology Identification of Acacia senegal Phytochemicals as Potential α-Amylase Inhibitors计算机模拟与网络药理学鉴定Acacia senegal植物化学物质作为潜在α-淀粉酶抑制剂DOI: 10.2174/0115734099489718260910060820
Current diabetes reviews IF: 01.900Ahead of Print.No.100Chronotherapeutic and Circadian Rhythm-Based Strategies in Diabetes Management: A Critical Opinion Based on Evidences糖尿病管理中的时间治疗与昼夜节律策略：基于证据的批判性观点DOI: 10.2174/0115733998495346261007070830
Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 6No.101Real-World Metabolic Improvements in Women With and Without Polyendocrine Metabolic Syndrome via a Multidisciplinary Telehealth Care Platform通过多学科远程医疗平台，患有多内分泌代谢综合征与不患该综合征的女性在真实世界中均获得代谢改善DOI: 10.1002/edm2.70332
Nanoscale IF: 05.100Ahead of Print.No.102Fibroblast-derived exosomes in wound healing and regenerative medicine: mechanisms, therapeutic potential, and clinical perspectives成纤维细胞来源外泌体在伤口愈合与再生医学中的机制、治疗潜力及临床前景DOI: 10.1039/d6nr01426g
Geriatr Gerontol Int IF: 02.500Volume 26, Issue 10No.103Comparison of Metabolic Dysfunction-Associated Steatotic Liver Disease Between Individuals With Werner Syndrome and Those With Insulin-Resistant Type 2 Diabetes: Hepatic Steatosis and Fibrosis IndicesWerner综合征患者与胰岛素抵抗型2型糖尿病患者代谢功能障碍相关脂肪性肝病的比较：肝脏脂肪变性和纤维化指标DOI: 10.1111/ggi.70866
Epidemiology and infection IF: 02.200Volume 154, Issue No.104Burden of RSV hospital disease and its comorbidities in adults in Spain (2016-2023)西班牙成人呼吸道合胞病毒住院疾病负担及其合并症（2016-2023年）DOI: 10.1017/S0950268826102076
Endocr Metab Immune Disord Drug Targets IF: 02.000Ahead of Print.No.105Study of Krüppel-like Factor 14 rs4731702 Polymorphism in Type 2 Diabetes MellitusKrüppel样因子14 rs4731702基因多态性与2型糖尿病的研究DOI: 10.2174/0118715303406864260803042753
Current organic synthesis IF: 02.500Ahead of Print.No.106L-Arginine Schiff Bases for Diabetic Wound Healing via Nitric Oxide Synthase Inhibition: Synthesis, In Vitro Activity, and In Silico InsightsL-精氨酸席夫碱通过抑制一氧化氮合酶促进糖尿病伤口愈合：合成、体外活性及计算机模拟研究DOI: 10.2174/0115701794490198260909153846
Phys Chem Chem Phys IF: 02.900Ahead of Print.No.107Delineating the structural distortions in hIAPP protofibrils by rationally designed hexapeptides using computer simulations利用计算机模拟解析理性设计的六肽对hIAPP原纤维的结构破坏作用DOI: 10.1039/d6cp01811d
Diabetes Technol Ther IF: 06.300Ahead of Print.No.108Efficacy and Safety of the MiniMed™ Vivera™ Algorithm: Results from a First-in-Human Feasibility TrialMiniMed™ Vivera™算法的有效性与安全性：首次人体可行性试验结果DOI: 10.1177/15209156261496632
Canadian liver journal IF: 01.200Volume 9, Issue 3No.109Cardiometabolic comorbidity and health outcomes of persons with metabolic dysfunction-associated steatotic liver disease (MASLD) in Ontario, Canada加拿大安大略省代谢功能障碍相关脂肪性肝病患者的代谢相关合并症与健康结局DOI: 10.3138/canlivj-2026-0020
Curēus IF: 01.300Volume 18, Issue 9No.110Recurrent Pericarditis With Cardiac Tamponade in a Patient With Systemic Lupus Erythematosus: A Case Report系统性红斑狼疮患者复发性心包炎伴心脏压塞：一例病例报告DOI: 10.7759/cureus.116182
Respir Med Case Rep IF: 00.800Volume 64, Issue No.111Early-onset severe voriconazole-induced liver injury with progressive cholestasis in pulmonary aspergillosis: A case report肺曲霉病患者中伏立康唑诱导的早发性严重肝损伤伴进行性胆汁淤积：一例病例报告DOI: 10.1016/j.rmcr.2026.102522
Curēus IF: 01.300Volume 18, Issue 9No.112Triple Renal Pathology in a Patient With Myeloperoxidase-Associated Vasculitis, Diabetic Nephropathy, and Immunoglobulin A Nephropathy: A Case Report一例髓过氧化物酶相关性血管炎、糖尿病肾病与免疫球蛋白A肾病三重肾脏病理的病例报告DOI: 10.7759/cureus.116188
Current opinion in endocrine and metabolic researchVolume 33, Issue No.113The Evolving Genomic Landscape of Pediatric Papillary Thyroid Cancer儿童甲状腺乳头状癌基因组景观的演变DOI: 10.1016/j.coemr.2023.100483
Drug Des Devel Ther IF: 05.100Volume 20, Issue No.114Oral Obesity Medicines in the Era of Cardiovascular-Kidney-Metabolic Syndrome (CKM): Beyond Weight Loss Toward Disease Modification心血管-肾脏-代谢综合征时代的口服减重药物：超越减重，迈向疾病修饰DOI: 10.2147/DDDT.S637685
Ethnicity & health IF: 02.000Ahead of Print.No.115The association between body mass index and perioperative outcomes by ethnicity and socioeconomic status: a systematic review of systematic reviews体重指数与围手术期结局的关联：基于种族和社会经济地位的系统综述再综述DOI: 10.1080/13557858.2026.2733954
Annals of plastic surgery IF: 01.600Ahead of Print.No.116Impact of Postbariatric Body Contouring Procedures on Patient Body Weight and Metabolism减重术后身体塑形手术对患者体重和代谢的影响DOI: 10.1097/SAP.0000000000004928
Clin Exp Rheumatol IF: 03.300Ahead of Print.No.117Phenotype-based risk stratification for deep vein thrombosis in Behçet's disease: a global 10-year longitudinal study基于表型的白塞病深静脉血栓风险分层：一项全球10年纵向研究DOI: 10.55563/clinexprheumatol/ir8mqc
JAMA surgery IF: 14.900Ahead of Print.No.118Bariatric Surgery and Risk of Obesity-Related Cancer by Age and Sex减重手术与肥胖相关癌症风险：年龄和性别的影响DOI: 10.1001/jamasurg.2026.4798
Curr Allergy Asthma Rep IF: 04.600Volume 26, Issue 1No.119Obesity-Related Asthma: Structure and Inflammation肥胖相关哮喘：结构与炎症DOI: 10.1007/s11882-026-01302-4
Brain imaging and behavior IF: 02.400Volume 20, Issue 5No.120The role of neighborhood socioeconomic environment in the association between glycemic control and the developing brain社区社会经济环境在血糖控制与大脑发育关联中的作用DOI: 10.1007/s11682-026-01211-0
Sleep & breathing IF: 02.000Volume 30, Issue 6No.121A dynamic triad: why weight trajectory matters in pediatric obesity, sleep apnea, and metabolic risk动态三联征：为何体重轨迹在儿童肥胖、睡眠呼吸暂停与代谢风险中至关重要DOI: 10.1007/s11325-026-03838-1
Acta diabetologica IF: 02.900Ahead of Print.No.122GLP-1 receptor agonists and hair loss: adverse effect, epiphenomenon, or therapeutic paradox?GLP-1受体激动剂与脱发：不良反应、伴随现象还是治疗悖论？DOI: 10.1007/s00592-026-02812-3
Acta diabetologica IF: 02.900Ahead of Print.No.123Risk of recurrent acute pancreatitis with GLP-1 receptor agonists after prior pancreatitis: a systematic review既往胰腺炎后使用GLP-1受体激动剂复发性急性胰腺炎的风险：一项系统评价DOI: 10.1007/s00592-026-02809-y
Acta diabetologica IF: 02.900Ahead of Print.No.124Gestational diabetes mellitus in Italian diabetes clinics: clinical characteristics, screening practices and management from the amd annals registry意大利糖尿病诊所中的妊娠期糖尿病：来自AMD Annals注册中心的临床特征、筛查实践与管理DOI: 10.1007/s00592-026-02816-z
Journal of dental research IF: 05.900Ahead of Print.No.125GLP-1 Receptor Agonists in Dentistry: Promise, Pitfalls, and Evidence GapsGLP-1受体激动剂在牙科中的应用：前景、隐患与证据空白DOI: 10.1177/00220345261488338
Small IF: 12.100Ahead of Print.No.126Fenestrated Microneedle Biosensor for Continuous In Vivo Lactate Monitoring in Interstitial Fluid用于连续体内间质液乳酸监测的开窗微针生物传感器DOI: 10.1002/smll.76250
Expert Opin Pharmacother IF: 02.700Ahead of Print.No.127Obesity: oral therapy for those afraid of needles肥胖症：针对恐针患者的口服治疗DOI: 10.1080/14656566.2026.2749645
Current diabetes reviews IF: 01.900Ahead of Print.No.128Gliflozin-Derived SGLT2 Inhibitors: Recent Advances and Future Perspectives in the Management of Type 2 Diabetes格列净衍生的SGLT2抑制剂：2型糖尿病管理的最新进展与未来展望DOI: 10.2174/0115733998505609261006104914
Current drug delivery IF: 03.000Ahead of Print.No.129Pharmacological and Therapeutic Roles of Wild Pistachio and Its Nanoformulations in Endocrine, Metabolic, and Other Diseases: A Comprehensive Review野生开心果及其纳米制剂在内分泌、代谢及其他疾病中的药理与治疗作用：一项综合性综述DOI: 10.2174/0115672018452820261006095941
Strabismus IF: 00.800Ahead of Print.No.130Potocki-Shaffer syndrome associated with Brown syndrome: expansion of the ocular phenotype in a child with an 11p11.2-p11.12 deletionPotocki-Shaffer综合征合并Brown综合征：一例11p11.2-p11.12缺失患儿眼部表型的扩展DOI: 10.1080/09273972.2026.2746025
J Pediatr Gastroenterol Nutr IF: 02.600Ahead of Print.No.131Chronic conditions associated with paediatric onset inflammatory bowel diseases: A population-based study与儿童期起病炎症性肠病相关的慢性疾病：一项基于人群的研究DOI: 10.1002/jpn3.70609
Health Care Women Int IF: 00.900Ahead of Print.No.132Effects of 6- versus 12-week supervised multimodal exercise on health outcomes and adherence in women with obesity: A pilot study6周与12周监督下多模式运动对肥胖女性健康结局和依从性的影响：一项初步研究DOI: 10.1080/07399332.2026.2743908
J Pediatr Endocrinol Metab IF: 01.000Ahead of Print.No.133Fatty liver and adipokines: converging pathways linking insulin resistance to early atherosclerosis in obese children and adolescents脂肪肝与脂肪因子：肥胖儿童和青少年中连接胰岛素抵抗与早期动脉粥样硬化的汇聚通路DOI: 10.1515/jpem-2026-0302
J Clin Pharmacol IF: 02.300Volume 66, Issue 10No.134Mechanistic Prediction of Maternal, Fetal, and Amniotic Fluid Betamethasone Concentrations to Support Dosing Optimization in Pregnancy母体、胎儿及羊水中倍他米松浓度的机制性预测以支持妊娠期给药优化DOI: 10.1002/jcph.70308
J Clin Med Res IF: 02.000Volume 18, Issue 9No.135Common Carotid Artery Extra-Media Thickness as a Marker of Perivascular Obesity and Cardiometabolic Risk in Individuals Without Cardiovascular Disease颈总动脉外膜厚度作为无心血管疾病个体血管周围肥胖和心脏代谢风险的标志物DOI: 10.14740/jocmr6657
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.136Diabetes Mellitus in Patients with Schizophrenia: A Systematic Review and Meta-Analysis of Prevalence of Types and Risk Factors精神分裂症患者的糖尿病：类型患病率与风险因素的系统综述与荟萃分析DOI: 10.2147/DMSO.S650265
Canadian liver journal IF: 01.200Volume 9, Issue 3No.137Metabolic dysfunction-associated steatotic liver disease assessment and management: Clinical practice guidance from the Canadian Association for the Study of the Liver代谢功能障碍相关脂肪性肝病的评估与管理：加拿大肝病研究学会临床实践指南DOI: 10.3138/canlivj-2026-9-3-guidelines
Frontiers in toxicology IF: 04.600Volume 8, Issue No.138Mapping DEHP-induced metabolic dysregulation through multi-omics and systems biology: an adverse outcome pathway network approach通过多组学和系统生物学解析DEHP诱导的代谢失调：有害结局路径网络方法DOI: 10.3389/ftox.2026.1930835
Aesthet Surg J Open Forum IF: 01.900Volume 8, Issue No.139The Impact of Glucagon-Like Peptide-1 Receptor Agonist-Induced Nutritional Deficiencies on Skin Health: A Narrative Review With a Proposed Framework for the Aesthetic Practitioner胰高血糖素样肽-1受体激动剂诱导的营养缺乏对皮肤健康的影响：叙述性综述及为美容从业者提出的框架DOI: 10.1093/asjof/ojag169
Journal of the Endocrine Society IF: 03.100Volume 10, Issue 11No.140Potential links between PCOS/PMOS and Alzheimer disease and related dementias多囊卵巢综合征/多内分泌代谢性卵巢综合征与阿尔茨海默病及相关痴呆的潜在关联DOI: 10.1210/jendso/bvag206
Hepatobiliary Surg Nutr IF: 07.800Volume 15, Issue 5No.141Body mass index and ampulla of Vater cancer incidence and survival: a cohort study of 1.7 million Norwegians体重指数与Vater壶腹癌发病率和生存率：一项170万挪威人的队列研究DOI: 10.21037/hbsn-2024-636
Hepatobiliary Surg Nutr IF: 07.800Volume 15, Issue 5No.142Normal weight, hidden risk: adiposity is a better determinant of liver cancer than body mass index正常体重，隐藏风险：脂肪堆积比体重指数更能决定肝癌风险DOI: 10.21037/hbsn-2026-0411
BMFH IF: 02.900Volume 45, Issue 4No.143Bifidobacterium adolescentis protects the intestinal barrier from obesity-related inflammatory stimuli in association with the nuclear translocation of nuclear factor kappa B青春双歧杆菌通过核因子κB核转位保护肠道屏障免受肥胖相关炎症刺激DOI: 10.12938/bmfh.2026-022
Acta gastroenterológica latinoamericanaVolume 56, Issue 3No.144Glucagon-Like Peptide-1 Receptor Agonist and Gastrointestinal Adverse Effects: A Comprehensive Review胰高血糖素样肽-1受体激动剂与胃肠道不良反应：综合综述DOI: 10.52787/agl.v56i3.690
Int J Womens Health IF: 02.600Volume 18, Issue No.145Burden, Trends, and Future Projections of Polycystic Ovary Syndrome in the Gulf Cooperation Council Countries, 1990-2023, with Projections to 2050: A Global Burden of Disease Study海湾合作委员会国家多囊卵巢综合征的疾病负担、趋势及未来预测（1990-2023年，并预测至2050年）：一项全球疾病负担研究DOI: 10.2147/IJWH.S644317
Przegl?d Menopauzalny IF: 01.700Volume 25, Issue 2No.146Associations between body composition, physical activity, and life satisfaction in perimenopausal women aged 40-50 years: a cross-sectional study40-50岁围绝经期女性体重指数、体力活动与生活满意度的关联：一项横断面研究DOI: 10.5114/pm.2026.163868
BMJ Global Health IF: 06.100Volume 11, Issue 10No.147Estimating the potential health impact of taxing sugar-sweetened drinks in Thailand: a modelling study估算泰国对含糖饮料征税的潜在健康影响：一项建模研究DOI: 10.1136/bmjgh-2025-021625
Nature IF: 48.500Ahead of Print.No.148Artificial intelligence-enabled clinical phenotyping of human brown fat - Nature人工智能赋能的人类棕色脂肪临床表型分析DOI: 10.1038/s41586-026-11162-7
Frontiers in medicine IF: 03.000Volume 13, Issue No.149Cross-modal fusion of OCT and OCT angiography enface for improved diagnostics of diabetic retinopathyOCT与OCTA enface的跨模态融合提升糖尿病视网膜病变诊断效能DOI: 10.3389/fmed.2026.1900570
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.150Investigating the effect of diet-induced prediabetes on the HPA-axis, sympathetic nervous system and endogenous opioids in male Sprague-Dawley rats探究饮食诱导的糖尿病前期对雄性Sprague-Dawley大鼠HPA轴、交感神经系统及内源性阿片系统的影响DOI: 10.3389/fendo.2026.1925577
Frontiers in nephrologyVolume 6, Issue No.151SGLT2 inhibitors as a strategy for volume management in peritoneal dialysis: a case series钠-葡萄糖协同转运蛋白2抑制剂作为腹膜透析容量管理策略：病例系列DOI: 10.3389/fneph.2026.1942462
FCVM IF: 02.900Volume 13, Issue No.152Cardiovascular outcomes of oral incretin-based drugs in type 2 diabetes: a GRADE-assessed meta-analysis of 67,679 patients口服肠促胰素类药物在2型糖尿病中的心血管结局：一项纳入67,679例患者的GRADE评估荟萃分析DOI: 10.3389/fcvm.2026.1884895
Med J Islam Repub IranVolume 40, Issue No.153Latent Class Analysis for Clustering Iranian Individuals Based on Cardiovascular Risk Factors基于心血管危险因素对伊朗个体进行聚类分析的潜在类别分析DOI: 10.47176/mjiri.40.88
3 biotech IF: 02.900Volume 16, Issue 11No.154Machine learning-driven discovery of TGFBR1 inhibitors from Mangifera indica for Atorvastatin-based antidiabetic therapy机器学习驱动的芒果中TGFBR1抑制剂发现及其用于基于阿托伐他汀的降糖治疗DOI: 10.1007/s13205-026-05088-0
JCEM case reportsVolume 4, Issue 11No.155Aortic coarctation and McArdle disease in histiocytosis-lymphadenopathy plus syndrome: expanding the SLC29A3 spectrum组织细胞增生症-淋巴结病附加综合征中的主动脉缩窄与McArdle病：扩展SLC29A3谱系DOI: 10.1210/jcemcr/luag289
JCEM case reportsVolume 4, Issue 11No.156Hypoinsulinemic hypoglycemia with hemihypertrophy in a Filipino infant: management in a resource-limited setting一例菲律宾婴儿低胰岛素性低血糖伴偏身肥大：资源有限环境下的管理DOI: 10.1210/jcemcr/luag231
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.157Commentary: Pembrolizumab-induced type-1 diabetes mellitus: clinical characteristics, therapeutic strategies, and prognosis from a retrospective analysis of 43 published cases评论：帕博利珠单抗诱导的1型糖尿病——基于43例已发表病例回顾性分析的临床特征、治疗策略与预后DOI: 10.3389/fendo.2026.1986405
Frontiers in nutrition IF: 05.100Volume 13, Issue No.158Comparative accuracy of automated carbohydrate estimation using NutriDish and ChatGPT-5 against dietitian-derived reference valuesNutriDish与ChatGPT-5自动估算碳水化合物的准确性比较：以营养师推导的参考值为基准DOI: 10.3389/fnut.2026.1927840
Med J Islam Repub IranVolume 40, Issue No.159Introducing Prostaglandin Endoperoxide Synthase-2 as a Remarkable Player in the Development of Gastroesophageal Reflux Disease前列腺素内过氧化物合酶-2在胃食管反流病发展中的重要作用DOI: 10.47176/mjiri.40.78
Indian journal of orthopaedics IF: 01.100Volume 60, Issue 10No.160Predictors of Non-union in Subtrochanteric Femur Fractures: A Multivariate Logistic Regression Analysis股骨转子下骨折不愈合的预测因素：多因素Logistic回归分析DOI: 10.1007/s43465-026-01882-3
Curēus IF: 01.300Volume 18, Issue 9No.161Predictive Factors for Diabetes Insipidus and Syndrome of Inappropriate Secretion of Antidiuretic Hormone After Transsphenoidal Surgery for Pituitary Adenoma垂体腺瘤经蝶手术后尿崩症与抗利尿激素不适当分泌综合征的预测因素DOI: 10.7759/cureus.116176
Med J Islam Repub IranVolume 40, Issue No.162Diabetes Status and the Association Between a Coronary Artery Disease Polygenic Risk Score and Incident Coronary Artery Disease in an Iranian Prospective Cohort糖尿病状态与伊朗前瞻性队列中冠状动脉疾病多基因风险评分及新发冠状动脉疾病之间的关联DOI: 10.47176/mjiri.40.89
AME case reports IF: 00.700Volume 10, Issue No.163Where did the iron go?-a case report of a patient with severe iron deficiency anemia despite parenteral and oral iron supplementation due to semaglutide application铁去哪儿了？——一例因应用司美格鲁肽导致尽管接受肠外和口服铁补充仍出现严重缺铁性贫血患者的病例报告DOI: 10.21037/acr-2026-0027
Indian journal of orthopaedics IF: 01.100Volume 60, Issue 10No.164Occurrence and Determinants of Periprosthetic Fractures of the Femur During Intraoperative and Post-operative Period in Patients Undergoing Hip Arthroplasty: A Prospective Cohort Study髋关节置换术患者术中及术后股骨假体周围骨折的发生率及决定因素：一项前瞻性队列研究DOI: 10.1007/s43465-026-01808-z
JCEM case reportsVolume 4, Issue 11No.165Primary adrenal small cell neuroendocrine carcinoma in a patient with sarcoidosis and synchronous colon adenocarcinoma结节病合并同步升结肠腺癌患者中原发性肾上腺小细胞神经内分泌癌一例DOI: 10.1210/jcemcr/luag313
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.166The CKM-GDM multi-organ precision model: reframing gestational diabetes as an early cardiovascular-kidney-metabolic event in Southeast AsiaCKM-GDM多器官精准模型：将妊娠期糖尿病重新定义为东南亚地区早期心血管-肾脏-代谢事件DOI: 10.3389/fendo.2026.1949130
FCVM IF: 02.900Volume 13, Issue No.167Effect of rosuvastatin and ezetimibe therapy on LDL-cholesterol reduction and non-invasive arterial injury markers in children with heterozygous familial hypercholesterolemia: a prospective, open-label, randomized study瑞舒伐他汀与依折麦布治疗对杂合子家族性高胆固醇血症儿童低密度脂蛋白胆固醇降低及无创动脉损伤标志物的影响：一项前瞻性、开放标签、随机研究DOI: 10.3389/fcvm.2026.1933757
Indian journal of orthopaedics IF: 01.100Volume 60, Issue 10No.168Body Mass Index-Related Changes in Tibial Morphology: Considerations for Intramedullary Nailing体重指数相关的胫骨形态变化：髓内钉置入的考量DOI: 10.1007/s43465-026-01921-z
Int J Hypertens IF: 01.700Volume 2026, Issue No.169From Adiposity to Diastolic Dysfunction: The Integrated Role of Epicardial Fat, Autonomic Dysregulation, and Morning Blood Pressure Surge in Obesity从肥胖到舒张功能障碍：心外膜脂肪、自主神经失调与晨峰血压在肥胖中的整合作用DOI: 10.1155/ijhy/8528281
J Diabetes Metab Disord IF: 01.600Volume 25, Issue 2No.170The hepato-thyroid axis in male obesity: unraveling inter-organ crosstalk through non-invasive biomarkers男性肥胖中的肝-甲状腺轴：通过无创生物标志物揭示器官间串扰DOI: 10.1007/s40200-026-02107-y
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.171The role of sitagliptin in modifying metabolic, hormonal and clinical parameters in polycystic ovarian syndrome patients: a randomized controlled trial西格列汀对多囊卵巢综合征患者代谢、激素及临床指标的影响：一项随机对照试验DOI: 10.3389/fphar.2026.1822226
AME case reports IF: 00.700Volume 10, Issue No.172Urogenital abscess with a complex etiology: a case report复杂病因的泌尿生殖系统脓肿：一例病例报告DOI: 10.21037/acr-2026-0132
Frontiers in Nuclear MedicineVolume 6, Issue No.173Absolute stress myocardial blood flow is reduced in patients with prior cardiac disease despite normal perfusion and ejection fraction on rubidium-82 PET: an Arabian Gulf cohort阿拉伯湾队列研究：既往心脏病患者尽管灌注和射血分数正常，但绝对负荷心肌血流量降低：一项铷-82 PET研究DOI: 10.3389/fnume.2026.1957482
N Am Spine Soc J IF: 02.500Volume 28, Issue No.174GLP-1 receptor agonists in elective spine surgery: a systematic review of fusion outcomes, perioperative safety, and procedure-specific risk胰高血糖素样肽-1受体激动剂在择期脊柱手术中的应用：融合结局、围手术期安全性和手术特异性风险的系统综述DOI: 10.1016/j.xnsj.2026.100942
DEN open IF: 01.500Volume 7, Issue 1No.175Evaluating a Modified American Society of Anesthesiologists Physical Status-Based Sedation Management System for Pancreatobiliary Endoscopy: A Prospective Feasibility Study评估基于改良美国麻醉医师协会体能状态分级的胰胆内镜镇静管理系统：一项前瞻性可行性研究DOI: 10.1002/deo2.70445
Afr J Reprod Health IF: 01.000Volume 30, Issue 19No.176Maternal risk factors for hypertension in pregnancy: A quantitative study on the role of demographics, obesity, and healthcare compliance妊娠期高血压的母体风险因素：关于人口统计学、肥胖和医疗依从性作用的定量研究DOI: 10.29063/ajrh2026/v30i19.7
Frontiers in immunology IF: 05.900Volume 17, Issue No.177Saccharomyces boulardii reduces food intake and attenuates weight gain in diet-induced obese mice: links to gut microbial, metabolic, and immune remodeling布拉氏酵母菌减少饮食诱导肥胖小鼠的进食量并减轻体重增长：与肠道微生物、代谢及免疫重塑的关联DOI: 10.3389/fimmu.2026.1925200
Hypertension Research IF: 04.600Ahead of Print.No.178Pre-pregnancy BMI and hypertensive disorders of pregnancy in Japan: population burden and simulated BMI reduction scenarios for preconception and interpregnancy care日本孕前体重指数与妊娠期高血压疾病：人群负担及孕前和孕期保健中模拟体重指数降低情景DOI: 10.1038/s41440-026-02847-7
Arthritis & rheumatology IF: 10.900Ahead of Print.No.179Higher risk of Long COVID among patients with autoimmune rheumatic diseases and immunomodulatory therapy: a retrospective cohort analysis of national US data自身免疫性风湿病患者和免疫调节治疗中Long COVID风险更高：一项基于美国国家数据的回顾性队列分析DOI: 10.1002/art.70361
Nutrition journal IF: 03.800Volume 25, Issue 1No.180Intake of ultra-processed foods in Sweden and its association with diet quality and weight status: cross-sectional analyses from three national dietary surveys瑞典超加工食品摄入及其与膳食质量和体重状况的关联：来自三项全国膳食调查的横断面分析DOI: 10.1186/s12937-026-01408-5
Dermatology and therapy IF: 04.200Ahead of Print.No.181Obesity and Early Biologic Failure in Psoriasis: An Italian Multicentre Retrospective Cohort Study肥胖与银屑病早期生物制剂治疗失败：一项意大利多中心回顾性队列研究DOI: 10.1007/s13555-026-01956-y
J Gen Intern Med IF: 04.200Ahead of Print.No.182Self-Reported Obesity Medicine Competence, Knowledge, and Attitudes Among US Medical Students: An Eight-School Pre- vs. Post-Intervention Study美国医学生自我报告的肥胖医学能力、知识和态度：一项八所学校干预前后研究DOI: 10.1007/s11606-026-10913-6
Eur Arch Psychiatry Clin Neurosci IF: 03.700Ahead of Print.No.183Testing whether prolactin and glucose associations differ by sex检验催乳素与血糖的关联是否存在性别差异DOI: 10.1007/s00406-026-02406-8
Communications biology IF: 05.100Volume 9, Issue 1No.184KCNQ1 disruption alters human neuronal development through mitochondrial and insulin signalling pathwaysKCNQ1缺失通过线粒体和胰岛素信号通路改变人类神经元发育DOI: 10.1038/s42003-026-11111-0
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.185Reappraising the Role of GH/IGF-I Axis and β-Cell Failure: Insights From Two Genetic Syndromes重新评估GH/IGF-I轴与β细胞衰竭的作用：来自两种遗传综合征的启示DOI: 10.1111/dom.71386
Proteomics IF: 03.900Ahead of Print.No.186Meet the Editorial Team. An Interview With Prof David Greening, Associate Editor, Proteomics, Baker Heart and Diabetes Institute, Melbourne, Australia认识编辑团队：专访澳大利亚墨尔本贝克心脏与糖尿病研究所蛋白质组学副主编David Greening教授DOI: 10.1002/pmic.70191
Crit Rev Ther Drug Carrier Syst IF: 02.500Volume 43, Issue 3No.187Stimuli-Responsive Wound Management: A Focus on Innovative pH-Driven Healing Systems刺激响应性伤口管理：聚焦创新的pH驱动愈合系统DOI: 10.1615/CritRevTherDrugCarrierSyst.2026058031
Nepal J Ophthalmol IF: 00.200Volume 17, Issue 34No.188Corneal Endothelial Morphology in Type II Diabetic versus Non-Diabetic Individuals using Specular Microscopy使用镜面显微镜比较II型糖尿病患者与非糖尿病个体的角膜内皮形态DOI: 10.3126/nepjoph.v17i34.74598
Arthroscopy : IF: 05.400Ahead of Print.No.189Arthroscopic Bankart Repair Is Associated With Lower 90-Day Emergency Department Use Than Open Repair, With Smoking, Medicaid Insurance, and Depression as Additional Independent Predictors关节镜Bankart修复术相比开放修复术与更低的90天急诊使用相关，吸烟、Medicaid保险和抑郁是额外的独立预测因素DOI: 10.1002/arj.70639
Nepal J Ophthalmol IF: 00.200Volume 18, Issue 35No.190Severity of Primary Open Angle Glaucoma at First Presentation and Associated Factors in Tertiary Hospital三级医院中原发性开角型青光眼首次就诊时的严重程度及相关因素DOI: 10.3126/nepjoph.v18i35.82846
Egyptian Journal of ImmunologyVolume 33, Issue 4No.191Impact of probiotic supplementation on serum klotho levels and inflammatory status in patients with diabetic kidney disease补充益生菌对糖尿病肾病患者血清klotho水平及炎症状态的影响DOI: 10.55133/eji.330404
IUBMB life IF: 03.200Volume 78, Issue 10No.192The Receptor for Advanced Glycation End Products: Regulation and Implications in Metabolic Diseases晚期糖基化终产物受体：在代谢性疾病中的调控与意义DOI: 10.1002/iub.70137
Can J Public Health IF: 02.600Ahead of Print.No.193Self-reported impact of the sugar-sweetened beverage tax on consumer attitudes among adults in Newfoundland and Labrador: A comparison with other Canadian provinces in 2021 and 2022含糖饮料税对Newfoundland and Labrador成年人消费者态度自我报告影响的比较研究：2021年和2022年与加拿大其他省份的对比DOI: 10.17269/s41997-026-01259-x
European journal of pediatrics IF: 02.600Volume 185, Issue 11No.194Exercise management in pediatric type 1 diabetes: a multicenter study of healthcare professionals' perspectives儿童1型糖尿病的运动管理：一项关于医疗保健专业人员观点的多中心研究DOI: 10.1007/s00431-026-07472-7
Prostate Cancer Prostatic Dis IF: 05.800Ahead of Print.No.195Fracture risk and fracture risk factor assessment among men at prostate cancer diagnosis前列腺癌诊断时男性的骨折风险及骨折风险因素评估DOI: 10.1038/s41391-026-01151-2
J Gen Intern Med IF: 04.200Ahead of Print.No.196Representation of the LGBTQIA+ Patient Community in Cardiovascular Disease Clinical GuidelinesLGBTQIA+患者群体在心血管疾病临床指南中的代表性DOI: 10.1007/s11606-026-10857-x
Nepal J Ophthalmol IF: 00.200Volume 17, Issue 34No.197Real-world Outcomes and Predictors of Vision Loss after Panretinal Photocoagulation for Diabetic Retinopathy: Five-year Follow-up全视网膜光凝治疗糖尿病视网膜病变后的真实世界结局与视力丧失预测因素：五年随访DOI: 10.3126/nepjoph.v17i34.86992
Nepal J Ophthalmol IF: 00.200Volume 17, Issue 34No.198Awareness, Knowledge, and Practice on Retinal Diseases at High-altitude of Nepal尼泊尔高海拔地区视网膜疾病的意识、知识与实践DOI: 10.3126/nepjoph.v17i34.68246
Epidemiology and infection IF: 02.200Volume 154, Issue No.199Presence of post-COVID-19 condition in six ethnic groups in Amsterdam, the Netherlands: a retrospectively reconstructed time interval approach荷兰阿姆斯特丹六个族裔群体中COVID-19后状况的存在情况：一项回顾性重建时间间隔方法研究DOI: 10.1017/S095026882610199X
Biomed Environ Sci IF: 04.100Volume 39, Issue 9No.200Long-term National Trends in the Prevalence of Type 2 Diabetes Mellitus and the Association with Social Determinants of Health in Korean Adults, 2007-20242007-2024年韩国成人2型糖尿病患病率的长期全国趋势及其与社会健康决定因素的关联DOI: 10.3967/bes2026.090
Toxicol Mech Methods IF: 02.700Ahead of Print.No.201Molecular Toxicological Mechanisms of Pharmaceutical Nitrosamines: DNA Damage, Metabolic Activation, Carcinogenesis, and Advanced Analytical Detection Strategies药物亚硝胺的分子毒理学机制：DNA损伤、代谢活化、致癌作用及先进分析检测策略DOI: 10.1080/15376516.2026.2749670
BMC pharmacology & toxicology IF: 02.700Volume 27, Issue 1No.202Correction to: In vitro comparative quality evaluation of different brands of metformin hydrochloride tablets available in Mekelle City, Tigray Regional State, Ethiopia更正：埃塞俄比亚提格雷州默克莱市市售不同品牌盐酸二甲双胍片的体外质量比较评价DOI: 10.1186/s40360-026-01202-3
Nepal J Ophthalmol IF: 00.200Volume 17, Issue 34No.203Evaluation of Optical Coherence Tomography Angiography Parameters following Intravitreal Ranibizumab Biosimilar in Diabetic Macular Oedema玻璃体腔注射雷珠单抗生物类似药治疗糖尿病性黄斑水肿后光学相干断层扫描血管成像参数的评估DOI: 10.3126/nepjoph.v17i34.69532
Nepal J Ophthalmol IF: 00.200Volume 18, Issue 35No.204Retinal Nerve Fibre Layer and Ganglion Cell Complex Thickness in Diabetes Mellitus without Diabetic Retinopathy无糖尿病视网膜病变的糖尿病患者视网膜神经纤维层和神经节细胞复合体厚度研究DOI: 10.3126/nepjoph.v18i35.75209
Nepal J Ophthalmol IF: 00.200Volume 18, Issue 35No.205Visual Outcomes of Ranibizumab Versus Bevacizumab in Diabetic Retinopathy: An Analytical Study雷珠单抗与贝伐珠单抗治疗糖尿病视网膜病变的视觉结局：一项分析性研究DOI: 10.3126/nepjoph.v18i35.82606
J Long Term Eff Med ImplantsVolume 36, Issue 2No.206Influence of Metabolic Syndrome on Peri-Implant Tissue Health and Disease: A Comparative Evaluation of Clinical, Radiographic, and Red Complex Microbiological Parameters代谢综合征对种植体周围组织健康与疾病的影响：临床、影像学和红色复合体微生物学参数的比较评估DOI: 10.1615/JLongTermEffMedImplants.2025061104
J Microbiol Biotechnol IF: 03.100Volume 36, Issue No.207Isolation and Characterization of Levilactobacillus brevis FBL-3 from Godeulppaegi Kimchi and Screening of Medium Components for γ-Aminobutyric Acid Production从Godeulppaegi Kimchi中分离鉴定Levilactobacillus brevis FBL-3及产γ-氨基丁酸培养基组分筛选DOI: 10.4014/jmb.2608.08011
BMC endocrine disorders IF: 03.300Volume 26, Issue 1No.208Levothyroxine dose requirements, oral bioavailability and gut microbiome enterotype dynamics during the early post-bariatric period: a single-centre, prospective, cohort study减重手术后早期左甲状腺素剂量需求、口服生物利用度及肠道微生物组肠型动态：一项单中心、前瞻性、队列研究DOI: 10.1186/s12902-026-02599-y
J Long Term Eff Med ImplantsVolume 36, Issue 2No.209Harnessing the Therapeutic Potential of Locally Delivered 1% Metformin Gel for Modulation of Clinical and Inflammatory Parameters in Peri-Implantitis Disease: A Prospective Clinical Evaluation利用局部递送1%二甲双胍凝胶调节种植体周围炎临床和炎症参数的治疗潜力：一项前瞻性临床评估DOI: 10.1615/JLongTermEffMedImplants.2025062172
Chemistry & biodiversity IF: 02.500Volume 23, Issue 10No.210Bioactive Compounds and Antidiabetic Properties of Launaea mucronata Hydroethanolic Extract: Phytochemical and Pharmacological InsightsLaunaea mucronata 氢乙醇提取物的生物活性化合物与抗糖尿病特性：植物化学与药理学见解DOI: 10.1002/cbdv.71780
Acta neuropsychiatrica IF: 02.500Volume 38, Issue No.211Effects of glucagon-like peptide-1 (GLP-1) mono-agonists on reward processing in animal models: a systematic review胰高血糖素样肽-1（GLP-1）单激动剂对动物模型奖赏加工的影响：一项系统综述DOI: 10.1017/neu.2026.10097
Alzheimer's & dementia IF: 11.100Volume 22, Issue 10No.212Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue死后脑组织中鞘脂和神经酰胺与tau病理的关联在不同种族群体中存在差异DOI: 10.1002/alz.71690
Expert Opin Pharmacother IF: 02.700Ahead of Print.No.213Pharmacotherapy for MASLD/MASH: approved therapies, drug repurposing, and emerging mechanism-based candidatesMASLD/MASH的药物治疗：已获批疗法、药物重定位及新兴机制候选药物DOI: 10.1080/14656566.2026.2749643
J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.214Iopanoic Acid in Severe Thyrotoxicosis: Rediscovering an Effective Therapy碘番酸在严重甲状腺毒症中的应用：重新发现一种有效疗法DOI: 10.1210/clinem/dgag421
204
Diabetes Mellitus(DM)
糖尿病
95
Obesity
肥胖症
54
Insulin
胰岛素
29
Type 2 diabetes mellitus(T2DM)
2型糖尿病
16
Semaglutide
司美格鲁肽
15
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
12
Diabetic Retinopathy
糖尿病视网膜病
9
Metformin
二甲双胍
7
Tirzepatide
替尔泊肽
7
Metabolic Syndrome
代谢综合征
5
Liraglutide
利拉鲁肽
4
Type 1 diabetes mellitus(T1DM)
1型糖尿病
4
Hypoglycemic Agents
降糖药
4
Diabetic Foot
糖尿病足
4
Diabetes Complications
糖尿病并发症
3
Diabetic acidosis
糖尿病性酸中毒
3
Sotagliflozin
索格列净
3
Dapagliflozin
达格列净
3
Pregabalin
普瑞巴林
3
Diabetic Peripheral Neuropathy(PDN)
糖尿病周围神经病变
3
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
3
Dulaglutide
度拉糖肽
3
gamma-Aminobutyric Acid(GABA)
γ-氨基丁酸
2
Exenatide
艾塞那肽
2
Gastrointestinal lipase inhibitor
胃肠道脂肪酶抑制剂
2
Orlistat
奥利司他
2
Empagliflozin
恩格列净
2
Sitagliptin
西他列汀
1
Diabetic Cardiomyopathies
糖尿病心肌病
1
Ertugliflozin
艾托格列净
1
Bexagliflozin
贝沙格列净
1
Canagliflozin
卡格列净
1
Alzheimer Disease and Diabetes Mellitus
阿尔茨海默病与糖尿病
1
Mazdutide
玛仕度肽
1
Orforglipron
奥氟格列隆
1
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
1
Diabetic Neuropathies
糖尿病性神经病变
1
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
1
Lixisenatide
利司那肽
1
Gabapentin
加巴喷丁
编辑：韩玉莲
审校：韩玉莲
临床结果
2026-08-27
·科学网
钠-葡萄糖协同转运蛋白2（SGLT2）研究报告
一、摘要
钠-葡萄糖协同转运蛋白2（SGLT2）是由SLC5A2基因编码的肾脏特异性主动转运蛋白，依托钠离子电化学梯度介导葡萄糖逆浓度梯度转运，承担人体肾脏80%~90%的滤过葡萄糖重吸收功能，是维持机体糖代谢稳态的核心分子。区别于胰岛素依赖的GLUT葡萄糖转运蛋白，SGLT2的转运功能不直接消耗ATP，凭借独特的钠糖协同转运机制，成为代谢性疾病诊疗的关键靶点。本报告系统阐述SGLT2的分子结构、生理功能、病理机制，全面解析SGLT2抑制剂（列净类药物）的研发历程、作用机制、临床应用及安全风险，同时梳理该靶点及靶向药物的前沿研究与发展趋势，为其在代谢、心肾疾病等领域的基础研究与临床转化提供理论支撑。
二、SGLT2分子基础与生理特征
2.1 基因与蛋白结构特征
人源SGLT2由16号染色体短臂的SLC5A2基因编码，基因全长约7kb，包含14个外显子，部分编码区域与反向链基因序列重叠，具备独特的基因结构特征。SGLT2与同家族SGLT1同源性仅59%，二者功能特性差异显著：SGLT2为低亲和力、高转运容量转运体，适配肾脏大批量糖重吸收生理需求；SGLT1为高亲和力、低转运容量转运体，主要负责肠道糖吸收及肾脏残余糖重吸收。
SGLT2蛋白由672个氨基酸残基组成，分子量约75kDa，属于SLC5家族跨膜蛋白，核心结构由10个保守跨膜α-螺旋构成，搭配4个辅助跨膜螺旋形成稳定空间骨架。蛋白功能区域可分为三大核心模块：一是中央葡萄糖结合域，依靠6个关键氨基酸残基与葡萄糖羟基形成氢键，结合芳香族氨基酸实现底物特异性固定；二是钠离子结合域，通过保守位点结合Na⁺，依托钠糖协同耦合机制激活转运功能；三是双门控转运通道，通过内外门构象交替开合，实现葡萄糖单向跨膜转运，杜绝底物反流。此外，蛋白N250位点的N-糖基化修饰是维持蛋白正确折叠、细胞膜定位及转运活性的关键，修饰缺失会直接导致蛋白功能失活。
2.2 转运作用机制
SGLT2的转运能量完全依赖基底侧膜Na⁺-K⁺-ATP酶构建的跨膜钠梯度，该酶持续消耗ATP将胞内Na⁺泵出，维持胞外高钠、胞内低钠的电化学势能，为葡萄糖逆浓度转运提供动力，整体转运过程分为四步循环。第一，构象准备，蛋白处于外向开放状态，Na⁺优先结合保守位点，诱导通道构象微调，适配葡萄糖结合空间；第二，底物结合，钠离子协同葡萄糖精准结合核心功能域，通过疏水作用与氢键固定底物；第三，构象闭锁，底物结合触发蛋白整体构象变化，外门关闭、内门预开放，隔离底物阻断反流；第四，底物释放与重置，胞内微环境降低底物亲和力，Na⁺与葡萄糖同步释放至胞质，蛋白恢复初始构象，开启新一轮转运。SGLT2严格遵循1:1的钠糖转运化学计量比，保障转运过程高效、稳定、无泄漏。
2.3 组织分布与生理功能
SGLT2表达具有高度组织特异性，生理状态下主要高表达于肾脏皮质近端小管S1、S2段，是肾脏糖重吸收的核心功能位点。人体每日肾小球滤过葡萄糖约180g，其中80%~90%由SGLT2在近端小管前段重吸收回血液，剩余10%~20%滤液葡萄糖由S3段的SGLT1代偿重吸收，双重转运体系保障正常人尿液无葡萄糖流失。葡萄糖进入肾小管上皮细胞后，通过基底侧GLUT2转运蛋白顺浓度梯度扩散入血，完成糖循环；协同转运的钠离子则经Na⁺-K⁺-ATP酶泵入肾间质，参与机体水钠代谢调节。
肾脏外SGLT2仅存在微量低水平表达，且多数无完整功能活性。小肠、肝脏、脑组织中可检测到SGLT2 mRNA，但蛋白表达量极低，无显著糖转运功能，仅可能参与局部代谢稳态微调；心脏、脂肪等组织几乎无功能性SGLT2蛋白表达。该特异性分布特征，决定了SGLT2靶向干预的肾脏针对性，大幅降低了脱靶干预的生理风险。同时，SGLT2介导的钠糖转运是肾脏管球反馈机制的重要上游信号，直接参与肾小球滤过率的动态调控，维系肾脏血流动力学稳态。
三、SGLT2异常与相关疾病的病理关联
3.1 家族性肾性糖尿
家族性肾性糖尿（FRG）是SLC5A2基因功能缺失突变引发的单基因遗传性小管疾病，也是首个被证实与SGLT2功能异常直接相关的人类疾病。SLC5A2基因纯合或复合杂合突变，会导致SGLT2蛋白膜定位异常、转运功能丧失，近端小管前段糖重吸收功能大幅衰减，造成血糖正常状态下持续性尿糖排泄。
该病临床预后良好，多数患者无明显不适症状，仅尿检提示尿糖阳性，得益于下游SGLT1的代偿重吸收功能，可避免大量能量流失与电解质紊乱。少数患者可出现多尿、轻微脱水或泌尿系统感染，无严重脏器损伤。SGLT2基因敲除动物模型与患者表型高度一致，肾脏糖重吸收能力下降90%，尿糖显著升高但血糖稳定，直接印证了SGLT2的核心生理功能。
3.2 2型糖尿病及糖尿病肾病
2型糖尿病（T2DM）病理状态下，长期高血糖会通过多重信号通路上调肾小管上皮细胞SGLT2的表达与活性，形成“高血糖→SGLT2亢进→糖重吸收增加→血糖进一步升高”的恶性循环，是糖尿病患者血糖难以管控的重要肾性机制。外周组织胰岛素抵抗导致葡萄糖利用障碍，叠加肾脏糖重吸收亢进，持续加剧机体糖代谢紊乱。
SGLT2异常激活是糖尿病肾病（DKD）启动与进展的核心始动因素，契合肾脏病变“小管假说”核心机制。SGLT2介导的钠糖重吸收增加，使流经致密斑的钠离子浓度下降，抑制肾脏保护性管球反馈，引发入球小动脉扩张、出球小动脉收缩，造成肾小球高滤过、高灌注状态。长期血流动力学异常会损伤肾小球滤过屏障，诱发微量白蛋白尿，逐步进展为显性蛋白尿。同时，高糖环境联合SGLT2亢进会激活氧化应激、晚期糖基化终末产物堆积及肾间质炎症纤维化通路，导致肾小球硬化、肾小管萎缩，最终进展为终末期肾病。此外，SGLT2介导的钠重吸收亢进会引发水钠潴留、血压升高，加重糖尿病大血管与微血管并发症。
3.3 心力衰竭与心血管疾病
SGLT2功能异常通过血流动力学与神经内分泌双重途径参与心力衰竭进展。一方面，SGLT2介导的钠水重吸收增加，提升机体循环容量负荷，增大心脏前后负荷与心室壁张力，长期诱发心肌病理性肥厚、心室重构；另一方面，SGLT2亢进会间接激活RAAS系统与交感神经系统，加剧神经激素紊乱，促进心肌纤维化、心肌细胞凋亡，加速心功能衰退。
该病理机制可脱离糖尿病独立存在，这也解释了SGLT2抑制剂对合并或不合并糖尿病的心衰患者均有保护作用的临床现象。同时，SGLT2异常引发的水钠潴留、血压升高、脂质代谢紊乱，会加速动脉粥样硬化进程，提升冠心病、高血压性心脏病等心血管疾病的发病风险。
3.4 其他潜在关联疾病
近年研究发现，SGLT2功能紊乱与多种代谢及慢性疾病存在潜在关联。在非酒精性脂肪性肝病中，肝脏微量表达的SGLT2异常激活会加重肝细胞糖异生与脂质沉积，激活肝脏慢性炎症，推动脂肪肝向脂肪性肝炎、肝硬化进展。在肿瘤领域，肿瘤细胞依赖糖酵解供能，SGLT2表达上调可提升肿瘤细胞葡萄糖摄取效率，助力肿瘤增殖、侵袭与转移，多项基础研究证实SGLT2抑制剂可抑制多种肿瘤细胞生长。此外，SGLT2介导的水钠代谢异常还参与肝硬化腹水、难治性高血压、睡眠呼吸暂停综合征等疾病的病理进程，相关机制仍在进一步验证中。
四、SGLT2抑制剂（列净类药物）研究与临床应用
4.1 药物研发历程
SGLT2抑制剂研发历经百年迭代，是从天然先导化合物到临床靶向药物的经典转化案例。19世纪末，研究者从苹果树根皮分离得到天然抑制剂根皮苷，可同时抑制SGLT1与SGLT2，具备降糖排糖效果，但因选择性差、易水解、生物利用度低，无法直接临床应用。上世纪90年代，通过结构改造将根皮苷O-糖苷键替换为稳定性更强的C-糖苷键，解决了代谢稳定性缺陷，奠定了合成类抑制剂的研发基础。2013年，首个SGLT2抑制剂卡格列净获FDA批准上市，随后达格列净、恩格列净、艾托格列净及国产恒格列净、贝沙格列净等陆续获批，实现药物迭代升级，新型药物在靶点选择性、安全性、药代动力学特性上持续优化。
4.2 核心作用机制
SGLT2抑制剂具备不依赖胰岛素的独特降糖机制，通过靶向结合肾脏近端小管SGLT2蛋白，将其固定于外向开放构象，阻断钠糖协同转运功能，减少肾小管葡萄糖重吸收，增加尿糖排泄，实现血糖调控。该机制完全独立于胰岛素分泌与胰岛素敏感性，可用于胰岛素抵抗、胰岛素分泌绝对不足的糖尿病患者。常规治疗剂量下，药物可降低肾脏40%~50%的糖重吸收能力，有效降糖且低血糖风险极低，当血糖低于肾糖阈时，药物排糖效应自动减弱，保障血糖稳态。
除降糖作用外，药物具备多重器官保护机制。肾脏保护层面，通过减少钠离子重吸收、激活管球反馈，收缩肾小球入球小动脉、优化肾内血流动力学，缓解肾小球高滤过状态，减轻肾脏氧化炎症损伤，延缓肾病进展。心脏保护层面，通过渗透性利尿排钠排水，降低循环容量负荷，减轻心脏前后负荷；同时抑制RAAS系统与交感神经过度激活，逆转心肌重构、抑制心肌纤维化，降低心衰住院与死亡风险。代谢保护层面，通过尿糖排泄形成适度热量负平衡，降低体重与内脏脂肪堆积，下调血尿酸、血脂水平，改善全身代谢紊乱。
4.3 临床应用适应症
随着临床证据不断完善，SGLT2抑制剂适应症已从单纯降糖拓展为多器官保护，成为代谢、心肾疾病的基础治疗药物。在2型糖尿病诊疗中，国内外指南均将其列为合并心血管疾病、心衰、慢性肾病患者的首选药物，无需局限于糖化血红蛋白水平，无合并症患者也可作为二甲双胍联用优选方案。在心力衰竭领域，无论患者是否合并糖尿病、无论射血分数高低，SGLT2抑制剂均可作为基础用药，降低心血管死亡与心衰再入院风险。在慢性肾脏病领域，可延缓肾功能衰退、减少蛋白尿，降低终末期肾病发生风险，适用于eGFR≥20ml·min⁻¹·1.73m⁻²的肾病患者。此外，药物在肝硬化腹水、非酒精性脂肪性肝病、肿瘤辅助治疗等领域的应用，已进入临床研究阶段，具备广阔拓展空间。
4.4 不良反应与安全管理
SGLT2抑制剂整体安全性良好，不良反应多为类别相关性，程度轻微且可防控。最常见的不良反应为泌尿生殖系统感染，尿糖升高营造细菌真菌易感环境，易引发尿道炎、外阴阴道炎，女性高发，通过多饮水、注意卫生、及时抗感染治疗可快速痊愈。其次为容量不足相关反应，药物利尿排钠效应可能引发轻度体位性低血压、脱水，多见于高龄、低血压、联用大剂量利尿剂患者，通过初始剂量滴定、动态监测容量状态可有效规避。
罕见严重不良反应包括正常血糖型酮症酸中毒、急性肾损伤、会阴部坏死性筋膜炎、下肢血管病变风险升高，发生率极低，多与感染、禁食、应激、基础血管病变等诱因相关。临床安全管理需严格把控禁忌症，重度肾功能不全、药物过敏、妊娠哺乳期患者严禁使用；治疗初期动态监测肾功能、电解质、血糖、酮体指标；对感染、手术、禁食等高风险患者及时调整用药，同时做好患者健康宣教，降低感染与脱水风险。不同药物安全性存在细微差异，国产贝沙格列净泌尿感染风险更低，恩格列净肾损伤防护优势更显著，可根据患者情况个体化选药。
五、前沿研究与发展趋势
5.1 联合治疗方案优化
基于机制互补性，SGLT2抑制剂与多种临床药物存在显著协同治疗效应，联合方案已成为临床研究热点与主流治疗趋势。与GLP-1受体激动剂联用，可同时实现控糖、减重、心肾三重保护，兼顾代谢负荷调控与血流动力学改善，是糖尿病合并心肾并发症的最优联合方案。与盐皮质激素受体拮抗剂联用，可协同抑制肾脏炎症纤维化、减少蛋白尿，双重延缓慢性肾病进展。与ARNI类药物联用，可全方位降低心脏前后负荷、抑制心肌重构，大幅提升难治性心力衰竭治疗效果。各类联合方案经大规模临床研究验证，疗效确切且不良反应无叠加，已纳入多项权威诊疗指南。
5.2 新适应症临床探索
当前SGLT2抑制剂新适应症探索聚焦三大核心领域。一是代谢功能障碍相关脂肪性肝病，多项临床研究证实药物可降低肝脏脂质沉积、减轻肝炎症损伤、改善肝功能，真实世界研究显示其可降低肝硬化、肝癌发生风险，有望成为新型肝病治疗药物。二是肝硬化难治性腹水，药物独特的排钠利尿效应可改善传统利尿剂抵抗，减少腹水蓄积、降低腹水相关死亡率，弥补了临床治疗短板。三是肿瘤辅助治疗，基础研究证实其可阻断肿瘤细胞葡萄糖能量供应，抑制肿瘤增殖转移，在肝癌、胰腺癌、肺癌等肿瘤中展现出潜在治疗价值，尤其适用于合并糖尿病的肿瘤患者。目前各类新适应症仍处于多中心临床研究阶段，待大规模证据落地后将进一步拓展药物临床价值。
5.3 新型靶向药物研发
为弥补现有药物短板，新一代SGLT靶向药物研发持续推进，主要分为两大方向。一是SGLT1/2双重抑制剂，在保留SGLT2高选择性抑制的基础上，适度阻断SGLT1介导的糖重吸收，进一步提升降糖排糖效率，同时通过结构优化规避肠道不良反应，目前多款候选药物处于临床前及Ⅰ期研究阶段。二是非糖苷类新型SGLT2抑制剂，采用全新药物骨架结构，摆脱传统糖苷键结合模式，具备更高靶点选择性、更优代谢稳定性，可降低脱靶风险与不良反应发生率，为精准靶向治疗提供新选择。
5.4 精准治疗体系构建
SGLT2抑制剂临床疗效存在显著个体差异，精准治疗成为未来核心发展方向。当前研究致力于挖掘疗效与风险相关生物标志物，包括尿SGLT2蛋白表达水平、SLC5A2基因多态性、基线血糖与肾功能指标、炎症及代谢标志物等。通过治疗前生物标志物检测，可精准筛选药物高获益人群、预判不良反应风险，实现个体化用药，规避无效治疗与高风险用药。未来随着检测技术与大数据体系的完善，基于患者基因、代谢、临床特征的SGLT2抑制剂精准治疗模式将逐步落地，大幅提升临床诊疗效率。
六、结论
SGLT2作为肾脏特异性钠糖协同转运蛋白，凭借独特的分子结构与转运机制，成为维系人体糖代谢稳态的核心靶点，其功能异常直接诱发肾性糖尿、糖尿病、糖尿病肾病等多种疾病，间接参与心血管、肝脏、肿瘤等多系统疾病的病理进展。SGLT2抑制剂突破了传统降糖药物的胰岛素依赖机制，通过肾脏排糖实现血糖调控，更兼具心、肾、代谢多器官保护效应，凭借确切的临床获益、良好的安全性，成为当代代谢心血管领域的里程碑式药物。
当前SGLT2靶点研究与药物临床转化已取得突破性进展，但新适应症验证、新型药物研发、精准治疗落地等方面仍存在探索空间。未来，随着基础研究的不断深入与临床证据的持续积累，SGLT2靶向治疗体系将更加完善，联合治疗方案持续优化、新型药物不断迭代、精准诊疗逐步普及，将进一步拓展该靶点的临床应用边界，为代谢性疾病、心肾疾病及多种疑难慢性疾病的治疗提供全新思路与方案，造福更多临床患者。
2026-08-22
·医药专利
1新药定义为含中国首次上市的活性成分，含原研在国外已批准在申报进中国的化药5.1类和生物药3.1类，不含非原研仿制或进口的化药3类、生物药2类
60 安弗利奇塔单抗注射液/益赛那®（2026.8.20）成人痛风性关节炎急性发作
2026年8月20日，国家药品监督管理局批准三生国健药业（上海）股份有限公司申报的1类生物创新药安弗利奇塔单抗注射液（皮下注射）（商品名：益赛那®）上市，用于对非甾体类抗炎药（NSAIDs）和/或秋水仙碱禁忌、不耐受或缺乏疗效，以及不适合反复使用类固醇激素的成人痛风性关节炎急性发作。
这是国产第二款获批的IL-1β单抗（继金赛药业伏欣奇拜单抗之后），也是三生国健2026年获批的第二款1类生物创新药（继2月益赛拓®之后）。该药也是上海市今年第5款获批上市的国产1类创新药。
安弗利奇塔单抗注射液（Anflekitug，SSGJ-613）｜商品名：益赛那®靶点：IL-1β | 机制：IgG1型人源化抗IL-1β单克隆抗体，阻断IL-1β介导的炎症通路企业：三生国健药业（上海）股份有限公司 | 注册分类：治疗用生物制品1类（国产创新）获批日期：2026年8月20日｜给药方式：皮下注射差异化：国产第二款IL-1β单抗，6小时快速镇痛，单次给药降低复发风险77%一、药品基本信息
项目
内容
药品名称
安弗利奇塔单抗注射液（益赛那®）
研发代号
SSGJ-613
注册分类
治疗用生物制品1类（国产创新）
靶点/机制
IL-1β——IgG1型人源化抗IL-1β单克隆抗体，阻断IL-1β介导的炎症通路
适应症
对NSAIDs和/或秋水仙碱禁忌、不耐受或缺乏疗效，以及不适合反复使用类固醇激素的成人痛风性关节炎急性发作
企业
三生国健药业（上海）股份有限公司
获批日期
2026年8月20日
给药方式
皮下注射二、痛风急性发作：4270万患者的"难言之痛"
痛风是我国高发的代谢性慢性病，成人患病率约3.2%，患者总数约4270万。急性发作时关节红肿剧痛，疼痛剧烈，被患者称为"生命中最痛的体验"。
传统一线治疗以NSAIDs、秋水仙碱、糖皮质激素为主。但三类药物均有明确的使用局限：
NSAIDs——合并慢性肾病（CKD）、消化道溃疡或出血史、心血管疾病患者慎用或禁用。中国痛风患者中约50%合并CKD或肾功能不全，CKD 3期以上（eGFR<60）患者NSAIDs风险显著增加。约20-30%的急性痛风患者存在NSAIDs禁忌或不耐受。
秋水仙碱——CKD 3期以上患者需减量，透析患者禁用。胃肠道不良反应（恶心、呕吐、腹泻）随剂量增加而增加，部分患者因不耐受停药。
糖皮质激素——反复使用可能导致血糖升高、血压升高、骨质疏松等代谢问题，不适合需要长期管理的高频发作患者。
益赛那®的获批适应症精准定位这一"难治"人群——对传统治疗方案禁忌、不耐受或缺乏疗效的患者。按4270万痛风患者中约20-30%存在传统治疗禁忌或不耐受估算，潜在适用人群约850-1280万人。三、作用机制：IL-1β是痛风炎症的关键启动因子
IL-1β是痛风急性发作炎症通路的关键启动因子。尿酸盐结晶沉积激活NLRP3炎症小体，释放大量IL-1β，驱动中性粒细胞浸润和炎症级联反应。安弗利奇塔单抗作为IgG1型人源化抗IL-1β单克隆抗体，高效精准锁定IL-1β的致病核心表位，阻断炎症信号传导。
SSGJ-613具有全新的可变区序列，与目前已上市的同靶点产品Canakinumab和Gevokizumab具有完全不同的结合表位。
临床数据显示，益赛那®可实现6小时快速缓解疼痛，单次给药降低复发风险77%，兼顾短期止痛与长期预防复发，安全性良好。这为传统治疗不耐受的患者提供了"快、防、护"一体化的精准抗炎方案。
II期临床研究（邹和建教授牵头，全国23家中心，发表于Int J Rheum Dis）纳入90例对NSAIDs/秋水仙碱禁忌或不耐受的急性痛风患者，对比SSGJ-613 200mg/300mg单次皮下注射与复方倍他米松肌注。72h疼痛降幅三组相当（-45.8mm vs -40.4mm vs -48.2mm，非劣效），6h起效。但12周新发痛风发作比例差异显著：200mg组仅16.7%，300mg组14.3%，而激素组高达51.6%（P<0.01）。中位首次复发时间：单抗组均未达到，激素组仅61天。200mg为III期优选剂量。
图2 7天VAS疼痛评分变化曲线
图3 首次发作时间生存曲线
图4 12周新发发作占比柱状图
III期确证性研究（NCT06169891）共纳入505例患者，48周周期，24周主要分析证实SSGJ-613在缓解急性疼痛方面与复方倍他米松相当，预防复发显著更优，安全性良好，无新发安全信号。四、竞争格局：IL-1β单抗赛道国产双雄并立
益赛那®是国产第二款获批的IL-1β单抗。首款为金赛药业的伏欣奇拜单抗，两者共同填补了国产IL-1β靶向药物在痛风领域的空白，形成"国产双雄"格局。
全球范围内，诺华的卡那奴单抗（2009年获批）为全球首款IL-1β单抗，虽开展过中国临床研究，但始终未在中国申报上市；Gevokizumab也曾在中国启动III期临床，后续未推进商业化。因此，国内IL-1β单抗市场将由伏欣奇拜单抗和安弗利奇塔单抗这两款国产药物主导。
近年来，国内痛风创新药从"降尿酸"和"抗炎"两个方向加速布局：
药物
企业
靶点
适应症
中国获批
鲁兹诺雷
恒瑞
URAT1
痛风伴高尿酸血症
2026（第27款）
伏欣奇拜单抗
金赛药业
IL-1β
痛风急性发作
2026（国产首款）益赛那®三生国健IL-1β痛风急性发作2026.8.20（国产第二款）
从恒瑞的URAT1抑制剂（降尿酸，控制源头）到金赛/三生国健的IL-1β单抗（抗炎镇痛，控制急性发作），国产痛风创新药正在形成"降尿酸+抗炎"的双线产品矩阵，覆盖痛风全病程管理。五、三生国健：自免管线加速兑现
益赛那®是三生国健2026年获批的第二款1类生物创新药。2026年2月，益赛拓®（安沐奇塔单抗，IL-17A）获批用于银屑病。两款新药均为自免领域，标志着三生国健在自免赛道的布局正在加速兑现。
三生国健2026年上半年营收8.66亿元，同比增长34.84%；归母净利润3.71亿元，同比增长95.10%。在已上市产品（益赛普、健尼哌等）稳定贡献现金流的同时，创新管线正在成为新的增长极。六、总结
• 创新机制——国产第二款IL-1β单抗，精准靶向痛风急性发作炎症通路关键启动因子
• 临床价值——6小时快速镇痛，单次给药降低复发风险77%，填补传统方案不耐受人群的治疗空白
• 适用人群——约850-1280万对传统抗炎药禁忌/不耐受的痛风患者，相当于4270万患者中的20-30%
• 三生国健里程碑——2026年第二款1类生物创新药，自免管线加速兑现
• 市场竞争——与恒瑞鲁兹诺雷（降尿酸）形成"降尿酸+抗炎"的国产痛风创新药矩阵
一句话总结：益赛那®是国产第二款IL-1β单抗，与金赛伏欣奇拜单抗形成"国产双雄"，为4270万中国痛风患者中约20-30%传统治疗不耐受的人群提供了精准抗炎新选择。三生国健在自免领域的布局，正在从"大单品益赛普"走向"多产品矩阵"。
2026中国获批新药链接
59.恒瑞立康可泮获批，国产第3款CFB的"头对头"底气，2026年中国第59款新药
58.天境生物CD38单抗菲泽妥单抗获批，2026年中国第58款新药
57.药捷安康胆管癌新药替恩戈替尼获批，2026年中国第57款新药
56.济川1.1类中药新药小儿通便颗粒获批，2026年中国第56款新药
55.华海瑞西奇拜单抗获批，2026年中国第55款新药
54.恒瑞舒地胰岛素获批，2026年中国第54款新药
53.西湖制药伊司特韦获批新冠，2026年中国第53款新药
52.九典椒七止痛凝胶贴膏获批，2026年中国第52款新药
51.海思科口服CFB抑制剂思普可泮片获批，2026年中国第51款新药
50.武田睡病新药OX2R激动剂奥普雷顿获批，2026年中国第50款新药
49.武田阿帕达酶α/辛奈达酶α获批，全球首个重组ADAMTS13，2026年中国第49款新药
48.通化金马阿尔茨海默病新药安维吖啶获批，2026年中国第48款新药
47.全球首个EGFR×HER3双抗ADC获批，2026年中国第47款新药
46.99万实体瘤CAR-T舒瑞基奥仑赛获批，2026年中国第46款新药
45.智翔金泰狂犬病双抗斯乐韦米单抗获批，2026年中国第45款新药
44.普莱医药抗菌肽培来加南喷雾剂获批，2026年中国第44款新药
43.礼来乳腺癌口服SERD依仑司群获批，2026年中国第43款新药
42.第一三共AML新药奎扎替尼获批，2026年中国第42款新药
41.康方银屑病新药古莫奇单抗获批，2026年中国第41款新药
40.默沙东婴儿长效RSV预防单抗克莱罗韦获批，2026年中国第40款新药
39.二代肺癌靶向新药康特替尼获批，2026年中国第39款新药
38.武汉朗来兰诺可泮获批，2026年中国第38款新药
37.从6类变1类新药，枣仁宁心滴丸获批，2026年中国第37款新药
36.舒泰神血友病新药波米泰酶α获批，2026年中国第36款新药
35.大冢斯贝利单抗获批，全球首个IgA肾病生物制剂，2026年中国第35款新药
34.安瑞曲替尼胶囊获批，国产第二代TRK抑制剂，不限瘤种精准靶向，2026年中国第34款新药
33.洛布替尼片获批，全球首个第四代BTK抑制剂，破解耐药难题，2026年中国第33款新药
32.塔拉妥单抗获批，全球首款DLL3/CD3双抗，改写小细胞肺癌后线治疗，2026年中国第32款新药
31.纳地美定获批，止痛不再"痛上加便秘"，2026年中国第31款新药
30.磷奈匹坦帕洛诺司琼获批化疗止吐迎来"双重锁"武器，2026年中国第30款新药
29.石药/康宁杰瑞HER2双抗胃癌新药安尼妥单抗上市，2026年中国第29款新药
28.诺思兰德基因治疗下肢缺血新药塞多明基上市，2026年中国第28款新药
27.恒瑞痛风新药鲁兹诺雷上市，2026年中国第27款新药
26.强生重症肌无力新药尼卡利单抗，2026年中国第26款新药
25 扬子江失眠新药法赞雷生，2026年中国第25款新药
24 宁波鞍石安达艾替尼获批用于肺癌，2026年中国第24款新药
23 杭州邦顺贝泽昔替获批用于骨髓纤维化，2026年中国第23款新药
22 阿斯利康曲麦利尤单抗获批，肝癌OS延长超11个月，2026年中国第22款新药
21地非法林获批，2026年中国第22款新药，齐鲁抢仿失策
20GSK ADC 玛贝兰妥单抗获批，2026年中国第20款新药
19拜耳塞伐艾替尼获批，2026年中国第19款新药
18.润都研发28年，心肌缺血诊断新药去甲乌药碱获批，2026年中国第18款新药，张雪峰事件引诊断价值讨论
17.GSK 半年一针哮喘新药德莫奇单抗上市，2026年中国上市的第17款新药
16.阿斯利康特泽利尤单抗上市，2026年中国上市的第16款新药
15.三生长效EPO罗赛促红素α上市，2026年中国上市的第15款新药
14.济民可信非小细胞肺癌新药索西美雷塞上市，2026年中国上市的第14款新药
13.正大天晴骨髓纤维化新药罗伐昔替尼片上市，2026年中国上市的第13款新药
12.三生银屑病新药安沐奇塔单抗上市，2026年中国上市的第12款新药
11.礼来溃疡性结肠炎新药米吉珠单抗上市，2026年中国上市的第11款新药
10.溃疡性结肠炎新药艾曲莫德上市，2026年中国上市的第10款新药
9.T2DM新药贝沙格列净上市，2026年中国上市的第9款新药
8.罕见病HoFH用洛美他派6个月审批上市，2026年中国上市的第8款新药
7.第11款 GLP-1R 先为达降糖药埃诺格鲁肽获批上市，2026年中国上市的第7款新药
6.安科生物销售的进口长效隆培生长激素获批上市，2026年中国上市的第6款新药
5.华辉安健FIC定肝新药立贝韦塔单抗获批上市，2026年中国上市的第5款新药
4.东阳光糖尿病新药奥洛格列净上市，2026年中国上市的第4款新药
3.新型铁载体超级抗生素，盐野义新药头孢德罗上市，2026年中国上市的第3款新药
2.FCS罕见病小核酸药物，赛诺菲新药普乐司兰上市，2026年中国上市的第2款新药
1.FIC惹争议，恒瑞新药瑞拉芙普α上市，2026年中国上市的第1款新药
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上市批准临床3期
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研发状态
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10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 2型糖尿病 | 美国 | 2023-01-20 |
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10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 原发性高血压 | 临床3期 | 美国 | 2017-10-18 |
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临床结果
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分期
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床3期 | 317 | Brenzavvy+Metformin | 遞願顧遞繭壓築築鏇醖(鹽觸鑰觸憲蓋廠艱廠鑰) = 顧網築衊築鹹願簾夢鹽 壓願糧觸鑰艱網醖選鑰 (糧製範衊積顧願簾鏇蓋 ) 更多 | 积极 | 2023-08-04 | ||
placebo+Metformin | 遞願顧遞繭壓築築鏇醖(鹽觸鑰觸憲蓋廠艱廠鑰) = 遞壓製選壓齋淵窪鑰鏇 壓願糧觸鑰艱網醖選鑰 (糧製範衊積顧願簾鏇蓋 ) 更多 | ||||||
临床3期 | 1,701 | Placebo | 淵遞艱範鹽窪顧網範築(憲淵顧壓網願壓餘衊繭) = 製觸艱膚襯窪願齋願遞 鬱網築觸顧網艱選構範 (鹽廠餘願顧構衊選襯獵, 0.04) 更多 | 积极 | 2023-01-20 | ||
淵遞艱範鹽窪顧網範築(憲淵顧壓網願壓餘衊繭) = 廠膚蓋齋醖壓膚廠鹹顧 鬱網築觸顧網艱選構範 (鹽廠餘願顧構衊選襯獵, 0.03) 更多 | |||||||
临床3期 | 426 | BRENZAVVY+Metformin | 廠糧憲鹹窪壓網築鑰糧(觸淵築製鹽鑰廠願糧鏇) = 衊選齋顧願壓糧簾繭鑰 淵構鹹蓋積壓範艱膚襯 (遞製夢糧醖夢壓鑰鬱淵, 0.1) 更多 | 积极 | 2023-01-20 | ||
Glimepiride+Metformin | 廠糧憲鹹窪壓網築鑰糧(觸淵築製鹽鑰廠願糧鏇) = 積廠構網繭糧憲繭遞簾 淵構鹹蓋積壓範艱膚襯 (遞製夢糧醖夢壓鑰鬱淵, 0.1) 更多 | ||||||
临床3期 | 312 | Placebo | 衊壓壓醖糧鏇淵憲夢願(選膚窪願構廠鏇築壓觸) = 艱膚壓鏇構鹹範廠願淵 鏇鑰範廠蓋鑰鹹襯製衊 (廠積糧築壓選壓窪壓艱, 0.1) 更多 | 积极 | 2023-01-20 | ||
衊壓壓醖糧鏇淵憲夢願(選膚窪願構廠鏇築壓觸) = 壓網鬱鹽糧艱構製觸繭 鏇鑰範廠蓋鑰鹹襯製衊 (廠積糧築壓選壓窪壓艱, 0.1) 更多 | |||||||
临床3期 | 207 | 網壓觸鹹構範餘顧顧艱(淵膚製蓋願鹽餘鑰膚顧) = 醖鬱憲醖糧艱衊製鑰鑰 鏇廠糧窪製醖觸襯願願 (壓淵夢構簾艱窪齋壓齋, 0.1) 更多 | 积极 | 2023-01-20 | |||
Placebo | 網壓觸鹹構範餘顧顧艱(淵膚製蓋願鹽餘鑰膚顧) = 蓋繭選鹹鏇觸願憲顧淵 鏇廠糧窪製醖觸襯願願 (壓淵夢構簾艱窪齋壓齋, 0.1) 更多 | ||||||
临床3期 | 317 | BRENZAVVY+ Metformin | 積鏇觸膚鑰醖簾願製廠(醖觸簾鹽選糧壓願鏇淵) = 鬱選餘淵範糧糧衊選鏇 窪廠製鬱艱醖壓積鬱餘 (選範鏇鬱鹹繭蓋膚蓋築, 0.1) 更多 | 积极 | 2023-01-20 | ||
Placebo+ Metformin | 積鏇觸膚鑰醖簾願製廠(醖觸簾鹽選糧壓願鏇淵) = 願鹽簾選鬱蓋鹹淵製壓 窪廠製鬱艱醖壓積鬱餘 (選範鏇鬱鹹繭蓋膚蓋築, 0.1) 更多 | ||||||
临床3期 | 384 | BRENZAVVY+Metformin | 艱夢糧糧齋製選鬱繭憲(艱築製膚艱憲膚選窪遞) = 範齋構襯選積簾淵構餘 選遞觸醖醖襯壓顧鑰夢 (窪繭構廠範構蓋鑰憲蓋, 0.1) 更多 | 积极 | 2023-01-20 | ||
Sitagliptin+Metformin | 艱夢糧糧齋製選鬱繭憲(艱築製膚艱憲膚選窪遞) = 襯鬱糧壓鬱繭廠衊鬱積 選遞觸醖醖襯壓顧鑰夢 (窪繭構廠範構蓋鑰憲蓋, 0.1) 更多 | ||||||
临床2/3期 | 673 | (Bexagliflozin Tablets, 20 mg) | 夢糧觸構獵願窪簾構夢(艱觸製網艱鬱糧齋構淵) = 獵遞網鑰鹽製構糧齋鬱 衊膚窪鏇鹽壓構構鬱襯 (廠餘憲餘醖廠鹽鑰鹹衊, 0.642) 更多 | - | 2021-09-21 | ||
Placebo (Placebo Tablets) | 夢糧觸構獵願窪簾構夢(艱觸製網艱鬱糧齋構淵) = 夢積壓壓蓋鹽鑰窪艱遞 衊膚窪鏇鹽壓構構鬱襯 (廠餘憲餘醖廠鹽鑰鹹衊, 0.622) 更多 | ||||||
临床1期 | 54 | (Group 1: Bexagliflozin Alone) | 醖夢顧鬱願憲構顧衊選(鏇構積夢衊鹽構襯蓋壓) = 顧糧膚鹽壓餘壓範壓夢 鹹構淵膚構廠壓憲憲簾 (鹹餘鏇簾築鹽網構艱製, 43.7) 更多 | - | 2021-07-22 | ||
(Group 1: Metformin Alone) | 膚獵膚觸艱襯獵範窪蓋(遞積壓顧餘膚製餘繭網) = 範鬱餘淵鹹積簾範構廠 築鏇齋齋簾壓壓壓鬱願 (繭獵範顧膚獵壓艱艱鑰, 27.2) 更多 | ||||||
临床1期 | 20 | (Digoxin Alone) | 憲蓋鏇鹹鏇積積窪膚襯(蓋願網窪夢齋憲鑰鑰鹽) = 網衊鏇鑰鑰夢廠製蓋顧 憲願獵鹹淵獵襯膚獵鹽 (網構積獵獵選遞製願鬱, 28.8) 更多 | - | 2021-07-16 | ||
(Digoxin With Bexagliflozin) | 憲蓋鏇鹹鏇積積窪膚襯(蓋願網窪夢齋憲鑰鑰鹽) = 襯網齋餘鹽窪壓衊鹽選 憲願獵鹹淵獵襯膚獵鹽 (網構積獵獵選遞製願鬱, 40.9) 更多 |
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