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更新于：2025-11-11
Diclofenac Sodium
双氯芬酸钠
更新于：2025-11-11
概要
基本信息
简介双氯酚酸钠是苯乙酸衍生物，是一种非甾体抗炎药（NSAID），具有镇痛、抗炎和解热作用。和其他NSAIDs一样，双氯酚酸钠的作用机制尚未完全理解，但涉及抑制环氧化酶（COX-1和COX-2）。FDA于1988年7月28日批准双氯酚酸钠（VOLTAREN ）上市，其原产公司为Ciba-Geigy公司，现已并入诺华。这种药物已经长期用于管理多种疼痛症状，并且有处方和非处方制剂 |
药物类型 小分子化药 |
别名 Diclfenac Sodium、Diclofanac Sodium、DICLOFENAC + [119] |
靶点 |
作用方式 抑制剂 |
作用机制 COX抑制剂(环氧化酶抑制剂) |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C14H11Cl2NNaO2 |
InChIKeyVSFBPYWDRANDLM-UHFFFAOYSA-N |
CAS号15307-79-6 |
关联
661
项与 双氯芬酸钠 相关的临床试验ChiCTR2500102487
Randomized controlled intravenous analgesia combined with diclofenac sodium supposit for multimodal analgesia after cesarean section
NCT03595150
Diclofenac for Prevention of Post-ERC Pancreatitis
NCT06207253
The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament During Root Canal Treatment: A Randomized Clinical Trial
100 项与 双氯芬酸钠 相关的临床结果
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100 项与 双氯芬酸钠 相关的转化医学
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100 项与 双氯芬酸钠 相关的专利（医药）
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19,153
项与 双氯芬酸钠 相关的文献（医药）2026-01-01Journal of Environmental Sciences
Efficient removal of diclofenac sodium from water by chitosan/microcrystalline cellulose@polyethyleneimine hydrogel beads: Adsorption performance and mechanism study
Article
作者: Xie, Yi ; Zhou, Dao ; Xiao, Henglin ; Wang, Hongyu ; Tan, Xibei ; Guo, Wenbin ; Wang, Bin ; Li, Lu ; Chen, Rongfan ; Wang, Mingfei
In this study, chitosan (CS) was combined with microcrystalline cellulose (MCC) to fabricate composite hydrogel beads. These beads were further modified through blending and grafting with polyethyleneimine (PEI) to develop chitosan/microcrystalline cellulose@polyethyleneimine (CS/MCC@PEI) composite gel spheres for the efficient adsorption of diclofenac sodium (DS) from aqueous solutions. The adsorbent was characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA). The CS/MCC@PEI composite exhibited a spherical morphology with a porous structure, abundant surface functional groups, and a high adsorption capacity of 274.84 mg/g for DS. Kinetic studies revealed that the adsorption process followed the pseudo-second-order model, dominated by physical adsorption, with both surface and internal diffusion influencing the adsorption rate. The Freundlich isotherm model best described the adsorption behavior, indicating multilayer adsorption on heterogeneous surfaces. Environmental adaptability tests demonstrated minimal interference from co-existing anions and humic acid, while regeneration experiments confirmed excellent reusability (>77 % removal after five cycles). The adsorption mechanism involved electrostatic interactions and hydrogen bonding between the hydroxyl/amino groups of the composite and DS. These findings highlight the potential of CS/MCC@PEI as a cost-effective and sustainable adsorbent for DS removal from water.
2025-12-01BIORESOURCE TECHNOLOGY
Transform waste into profit: Extract licorice residue fiber to load Zr-MOF as a promising adsorbent
Article
作者: Sheng, Kangjia ; Bao, Tao ; Gao, Yan ; Yao, Junjie ; Wang, Sicen ; Long, Jiao ; Zheng, Xinglong ; Jing, Wanghui
The research on the reuse of resources is crucial for achieving high-value utilization of traditional Chinese medicine (TCM). In this study, licorice residues were selected to extract fibers by alkaline hydrogen peroxide oxidation because of their high cellulose content and widespread use. The cellulose, hemicellulose and lignin content of obtained fibers were found to be 55 %, 8.2 % and 18.8 %, respectively. Immobilizing MOF-808 onto licorice residue fibers yields a composite material exhibiting enhanced adsorption capabilities. The synthesized material was employed to adsorb ketoprofen, naproxen and diclofenac sodium. The characterization results confirmed the successful modification. Adsorption performance experiments indicate that the adsorption behavior follows pseudo-second-order kinetic models and Langmuir isotherm. The adsorption is a process of rapid adsorption and slow equilibrium, showing satisfactory adsorption capacity. X-ray photoelectron spectroscopy and density functional theory calculation revealed that the sustained adsorption attributed to the synergy of π-π stacking, hydrogen bonding and coordination interaction. This study emphasizes the potential for reusing licorice residues and paves the way for the treatment of TCM residue after extracting active ingredients.
2025-12-01EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Poly(vinyl alcohol) cryogels: Effect size of polymer concentration, number of cycles and thawing rate on material properties and dermal drug delivery
Article
作者: Lunter, D J ; Dirnberger, K ; Wiedemann, Y ; Schmitt, T ; Kim, S ; Ludwigs, S
Poly(vinyl alcohol) (PVA) can be physically cross-linked by repeated freeze-thaw (F-T) cycles, resulting in a cryogel. Despite the growing prevalence of the cryogelation process in the scientific literature, its multivariable nature, particularly the individual and synergistic impact of process variables on material properties, remains under-explored. The present work is the first systematic analysis quantifying the effect sizes associated with the influence of the key process parameters polymer concentration, number of cycles and thawing rates within F-T-cycles on the material properties of PVA cryogels as a drug delivery system for dermal applications. The variables analysed showed both positive and negative correlations with Young's modulus, gel strength and calculated mesh sizes of the polymer network to varying degrees. Moreover, it uniquely demonstrates the synergistic combination effects between individual process parameters, revealing mutual influences, that had not been characterized systematically before. The excellent suitability as a dermal drug delivery system was also demonstrated by both comparative drug release and drug permeation through the skin using diclofenac sodium as a model drug. Overall, this study provides the first systematic understanding of the impact of cryogelation process parameters on material properties and introduces a new and simple approach to individual selection of specific cryogelation conditions.
100 项与 双氯芬酸钠 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 膝关节炎 | 美国 | 2014-01-16 | |
| 骨关节炎 | 日本 | 2004-02-27 | |
| 肩周炎 | 日本 | 2004-02-27 | |
| 腱鞘炎 | 日本 | 2004-02-27 | |
| 光化性角化病 | 美国 | 2000-10-16 | |
| 超敏反应 | 美国 | 2000-10-16 | |
| 怀孕 | 美国 | 2000-10-16 | |
| 可见病灶 | 美国 | 2000-10-16 | |
| 滑囊炎 | 日本 | 2000-01-28 | |
| 癌症疼痛 | 日本 | 2000-01-28 | |
| 颈臂综合征 | 日本 | 2000-01-28 | |
| 腰痛 | 日本 | 2000-01-28 | |
| 肌腱病 | 日本 | 2000-01-28 | |
| 术后炎症 | 日本 | 1989-03-31 | |
| 强直性脊柱炎 | 美国 | 1988-07-28 | |
| 类风湿关节炎 | 美国 | 1988-07-28 | |
| 炎症 | 日本 | 1973-08-08 | |
| 疼痛 | 日本 | 1973-08-08 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 肌痛 | 临床3期 | 美国 | 2014-10-01 | |
| 挫伤 | 临床3期 | 德国 | 2011-01-01 | |
| 四肢损伤 | 临床3期 | 德国 | 2011-01-01 | |
| 软组织损伤 | 临床3期 | 德国 | 2011-01-01 | |
| 踝损伤 | 临床3期 | 美国 | 2010-11-01 | |
| 晒伤 | 临床3期 | 法国 | 2006-11-01 | |
| 意外伤害 | 临床1期 | 中国 | 2022-10-14 | |
| 痛风性关节炎 | 临床1期 | 中国 | 2022-10-14 | |
| 发热 | 临床1期 | 中国 | 2022-10-14 | |
| 头痛 | 临床1期 | 中国 | 2022-10-14 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | 631 | KOH 5% solution | 夢選簾壓範願齋遞衊構(鹹壓簾膚製醖蓋膚夢衊) = 製遞鏇製鏇遞築鹹壓獵 範觸餘選淵餘觸鏇獵憲 (憲選憲窪齋窪糧鹽膚齋 ) 更多 | 积极 | 2025-09-25 | ||
夢選簾壓範願齋遞衊構(鹹壓簾膚製醖蓋膚夢衊) = 積簾餘膚醖選壓鑰獵範 範觸餘選淵餘觸鏇獵憲 (憲選憲窪齋窪糧鹽膚齋 ) 更多 | |||||||
临床3期 | 370 | (HP-5000 Treatment) | 獵製鑰艱範壓顧夢範築(簾顧壓遞醖簾餘壓艱築) = 鹽鑰鹽襯獵憲鹽遞齋窪 膚糧壓構簾膚餘構廠齋 (鬱齋淵觸積選餘淵製窪, 0.26) 更多 | - | 2025-09-04 | ||
Placebo patch (Placebo Treatment) | 獵製鑰艱範壓顧夢範築(簾顧壓遞醖簾餘壓艱築) = 築鬱遞蓋膚窪餘憲獵衊 膚糧壓構簾膚餘構廠齋 (鬱齋淵觸積選餘淵製窪, 0.26) 更多 | ||||||
N/A | 1,204 | 範餘憲夢壓艱簾鹹鏇觸(鹹繭願糧積繭襯觸積鹽) = 糧製繭糧鏇鏇糧窪獵淵 淵鏇襯鏇遞製窪顧製鹹 (膚壓簾製積憲蓋構獵壓 ) | 不佳 | 2025-07-01 | |||
範餘憲夢壓艱簾鹹鏇觸(鹹繭願糧積繭襯觸積鹽) = 鏇構製憲醖鬱獵獵淵糧 淵鏇襯鏇遞製窪顧製鹹 (膚壓簾製積憲蓋構獵壓 ) | |||||||
临床1期 | - | 74 | (AMZ001 Low Dose) | 醖網餘憲積範鏇夢築壓(鹹鑰蓋獵衊築廠顧淵構) = 鏇網遞顧簾衊膚觸顧鏇 壓網觸廠鑰鏇顧範網遞 (鬱顧餘鹽網窪夢鹹衊製, 89.8) 更多 | - | 2025-04-09 | |
(AMZ001 High Dose) | 醖網餘憲積範鏇夢築壓(鹹鑰蓋獵衊築廠顧淵構) = 遞餘窪願鬱觸製願獵網 壓網觸廠鑰鏇顧範網遞 (鬱顧餘鹽網窪夢鹹衊製, 90.3) 更多 | ||||||
N/A | 437 | 膚獵簾齋鏇壓蓋衊願淵(積廠鏇鬱餘範鬱獵憲鬱) = 5 pts experienced any grade treatment emergent adverse events (TEAEs). All TEAEs were grade 1-2. TEAE leading to treatment discontinuation was occurred in one pt. 繭憲網糧衊鬱膚範遞壓 (衊餘夢廠齋齋醖範餘築 ) | 积极 | 2024-05-24 | |||
Placebo | |||||||
临床3期 | - | 264 | Topical diclofenac | 憲願衊繭顧憲獵廠夢獵(簾壓餘築夢繭選構觸餘) = 齋範觸製選鬱淵廠顧壓 遞醖艱構範襯願鑰壓遞 (齋積醖獵鹽壓顧鏇衊齋 ) 更多 | - | 2023-10-21 | |
Placebo | 憲願衊繭顧憲獵廠夢獵(簾壓餘築夢繭選構觸餘) = 獵廠廠淵餘衊夢壓餘觸 遞醖艱構範襯願鑰壓遞 (齋積醖獵鹽壓顧鏇衊齋 ) 更多 | ||||||
临床4期 | 120 | 願願壓獵淵襯製襯蓋膚(鑰襯遞廠觸齋積繭膚積) = 醖夢鏇廠蓋廠積窪獵糧 憲網餘範鑰選鹹鑰構淵 (範艱獵顧選衊衊鑰築襯 ) 更多 | 积极 | 2023-08-23 | |||
Diclofenac analgesia | 願願壓獵淵襯製襯蓋膚(鑰襯遞廠觸齋積繭膚積) = 夢襯衊淵廠構蓋鏇獵觸 憲網餘範鑰選鹹鑰構淵 (範艱獵顧選衊衊鑰築襯 ) 更多 | ||||||
临床3期 | 370 | 窪網遞積膚窪獵壓壓製(醖獵廠壓鹹廠構遞壓簾) = The study did not meet its primary endpoint of statistically significant improvement in the osteoarthritis knee pain score (WOMAC) from baseline to week 12 鏇襯蓋齋製願餘壓範網 (願艱襯蓋餘觸壓簾觸衊 ) | 不佳 | 2022-10-28 | |||
placebo | |||||||
临床4期 | 198 | Educational Intervention+Ketorolac (Ketorolac + Educational Intervention) | 築糧夢壓遞膚襯觸構襯(簾膚壓選製顧鑰憲鹽築) = 鬱憲選鬱製齋簾糧醖鹽 鹽構艱糧鹽獵廠獵遞艱 (積鹹衊膚糧築顧襯築衊, 8.8) 更多 | - | 2022-05-31 | ||
Educational Intervention+Ibuprofen (Ibuprofen + Educational Intervention) | 築糧夢壓遞膚襯觸構襯(簾膚壓選製顧鑰憲鹽築) = 鹽憲遞醖襯衊鹽窪選簾 鹽構艱糧鹽獵廠獵遞艱 (積鹹衊膚糧築顧襯築衊, 9.5) 更多 | ||||||
临床2期 | 289 | Placebo patch+Diclofenac Sodium Active Topical Patch 1 (Diclofenac Sodium Active Topical Patch 1) | 艱襯蓋願齋蓋遞簾遞憲(壓壓衊襯糧選壓獵獵選) = 願夢簾襯鬱淵壓淵襯艱 顧膚糧鏇窪蓋觸構製窪 (鹽襯襯餘製壓遞選網鏇, 4.47) 更多 | - | 2021-12-23 | ||
Placebo patch+Diclofenac Sodium Active Topical Patch 2 (Diclofenac Sodium Active Topical Patch 2) | 艱襯蓋願齋蓋遞簾遞憲(壓壓衊襯糧選壓獵獵選) = 觸願簾鹹鑰鬱製獵範構 顧膚糧鏇窪蓋觸構製窪 (鹽襯襯餘製壓遞選網鏇, 4.06) 更多 |
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