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更新于：2025-09-01
Sufentanil Citrate
枸橼酸舒芬太尼
更新于：2025-09-01
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构/序列
分子式C28H38N2O9S |
InChIKeyOJCZPLDERGDQRJ-UHFFFAOYSA-N |
CAS号60561-17-3 |
关联
228
项与 枸橼酸舒芬太尼 相关的临床试验NCT06968546
Randomized Controlled Study Comparing Sufentanil and Ketamine Intranasally in the Management of Severe Acute Trauma-related Pain in Children.
ChiCTR2500100164
Efficacy and Safety of Hydromorphone or Sufentanil Combined With Programmed Epidural Intermittent Administration of Ropivacaine for Labor Analgesia ---- a Randomized, Controlled, Double-blind, Non-inferiority Study - Efficacy and Safety of Hydromorphone or Sufentanil Combined With Programmed Epidural Intermittent Administration of Ropivacaine for Labor Analgesia ---- a Randomized, Controlled, Double-blind, Non-inferiority Study
NCT07089173
The Effect-site Concentration of Remifentanil Blunting Endotracheal Intubation Responses During Anesthesia Induction With Lidocaine or Sufentanil Combined With Etomidate: A Randomized Controlled Study
100 项与 枸橼酸舒芬太尼 相关的临床结果
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100 项与 枸橼酸舒芬太尼 相关的转化医学
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100 项与 枸橼酸舒芬太尼 相关的专利（医药）
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1,886
项与 枸橼酸舒芬太尼 相关的文献（医药）2025-09-01TALANTA
SERS detection of analgesics in serum based on Ag nanocubes for perioperative monitoring
Article
作者: Qin, Lei ; Han, Lin ; Ji, Yinghe ; Wu, Jing ; Wang, Yunpeng ; Zhu, Zhuo ; Li, Yang ; Sun, Tingting
Prompt and personalized perioperative analgesia management relies on sensitive and convenient monitoring of analgesics. We report a strategy for sensitive and reproducible SERS detection of analgesics based on Ag nanocubes, which have abundant intragranular hot spots on sharp corners and interparticle hot spots between gaps. Both theoretical simulations and R6G detection experiments indicated that the enhancement factor of Ag nanocube SERS platform reach to 106 level. Quantitative and reproducible determination capabilities of this platform for six different analgesics with LOD as low as 500 pg mL-1 were verified. Pharmacokinetic experiment of fentanyl in rat serum samples by SERS detection within 4 h presented consistent results with the UHPLC-MS/MS method. Valid examples of SERS detection for single or multiple analgesics in clinical patients' serums further proved the feasibility of this platform for perioperative analgesic monitoring.
2025-06-01FOOD CHEMISTRY
High-throughput screening of new psychoactive substances and related compounds in food by UHPLC-Q/Orbitrap
Article
作者: Huang, Xia ; Wan, Yuping ; Shi, Peiyu ; Wu, Wenlin ; Xiao, Quanwei ; Liu, Shiyao ; Guo, Tianrong ; Chen, Xiaoqi ; Xia, Bing ; Zhang, Min ; Zhou, Yan
Currently, there is concern about food products to which new psychoactive substances (NPS) have been added illegally. However, rapid, high-sensitivity, and high-throughput screening methods for such harmful substances have not been reported yet. In this study, a high-throughput non-targeted screening strategy was developed based on UHPLC-Q/Orbitrap. First, optimized pretreatment methods for typical high-risk matrices were established. Second, an accurate, efficient, and scalable high resolution mass spectrometry database containing 206 NPS and related compounds was constructed. The fragmentation pathways of three different types of fentanyl-related compounds were then systematically investigated to enhance compound identification. Additionally, a non-targeted screening strategy was developed using warning ions derived from 24 fentanyl-related compounds, streamlining the identification of NPS. This strategy was applied to 100 food samples with possible illegal additives and demonstrated its effectiveness. In summary, this study provides robust technical support for regulatory authorities in combating the illegal addition of food products.
2025-06-01SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
A chemoinformatics study to prioritization of anticancer orally active lead compounds of pearl millet against adhesion G protein-coupled receptor
Article
作者: Shukla, Adarsh Kumar ; Neeru ; Kumar, Ashwani
Metastasis is the main cause of colon cancer deaths worldwide. However, due to the disease's complexity, understanding its spread and finding natural treatments remain major challenges. The study aimed to identify therapeutic compounds in pearl millet and test them on metastatic colon cancer cell lines. The study used LC-MS and FTIR spectroscopy to identify small compounds and their functional groups. Further, theoretical chemistry, computational techniques, and ADMET analysis were applied for virtual screening and evaluating the pharmacokinetics of potential bioactive candidates of pearl millet. The 55 compounds of pearl millet were identified through the LC-MS, whereas 37 compounds were reported in PubChem database. Out of these, 15 compounds were predicted as potential orally active leads of pearl millet. Adhesion G protein-coupled receptor F5 was found as a potential target of these lead candidates. Further, molecular docking exhibited Tosifen (-7.9 kcal/mol), Sufentanil (-6.4 kcal/mol), Pemirolast (-6.3 kcal/mol), and Levosimendan (-6.3 kcal/mol) have similar binding affinity to the antineoplastics against the targeted protein. The "root mean square fluctuations (RMSFs)" analysis and deformability graph validated the docked complexes. Additionally, a comparative cell lines study against colon adenocarcinoma highlights Pemirolast as a promising candidate, demonstrating better activity compared to standard antineoplastics. This computational study predicted potential anticancer compounds in pearl millet and recommended further investigation through in vitro and in vivo studies.
100 项与 枸橼酸舒芬太尼 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 急性疼痛 | 美国 | 2018-11-02 | |
| 疼痛 | 欧盟 | 2018-06-25 | |
| 疼痛 | 冰岛 | 2018-06-25 | |
| 疼痛 | 列支敦士登 | 2018-06-25 | |
| 疼痛 | 挪威 | 2018-06-25 | |
| 术后疼痛 | 欧盟 | 2015-09-18 | |
| 术后疼痛 | 冰岛 | 2015-09-18 | |
| 术后疼痛 | 列支敦士登 | 2015-09-18 | |
| 术后疼痛 | 挪威 | 2015-09-18 | |
| 麻醉 | 美国 | 1984-05-04 | |
| 阴道分娩过程 | 美国 | 1984-05-04 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 镇痛 | 临床2期 | 中国 | 2025-07-01 | |
| 突出痛 | 临床2期 | 美国 | 2009-04-01 | |
| 慢性疼痛 | 临床1期 | 中国 | 2023-03-08 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床1/2期 | 46 | (Sufentanil) | 膚觸構範鑰鏇繭繭築築(簾夢鬱簾簾艱廠餘夢顧) = 繭製鏇夢醖艱衊醖廠餘 淵鑰鑰壓範構憲構積壓 (淵醖鬱選膚鹹範憲餘鹹, 412) 更多 | - | 2024-07-11 | ||
Placebo (Placebo) | 膚觸構範鑰鏇繭繭築築(簾夢鬱簾簾艱廠餘夢顧) = 廠構築衊廠鬱構繭獵選 淵鑰鑰壓範構憲構積壓 (淵醖鬱選膚鹹範憲餘鹹, 271) 更多 | ||||||
临床4期 | - | 61 | (Intervention Group) | 網鹹願淵鏇簾衊網願積: Proportional odds ratio = 0.37 (95% CI, 0.13 ~ 1.07), P-Value = 0.067 更多 | - | 2023-12-13 | |
(Control Group) | |||||||
临床4期 | 10 | (Intra-operative Methadone Hydrochloride) | 餘鹹築壓醖繭遞簾夢鏇(壓糧網廠構淵鬱夢襯艱) = 鑰夢憲鹽壓壓淵齋選鑰 簾獵選鑰簾觸顧醖積淵 (築積蓋淵襯製鹹襯築遞, 糧鹹鬱壓壓齋鹹齋築廠 ~ 鑰憲製衊範製醖網蓋鏇) 更多 | - | 2023-04-25 | ||
(Control) | 餘鹹築壓醖繭遞簾夢鏇(壓糧網廠構淵鬱夢襯艱) = 願鑰膚糧顧夢鹹鹹艱鑰 簾獵選鑰簾觸顧醖積淵 (築積蓋淵襯製鹹襯築遞, 蓋鑰繭觸鹽願築願艱構 ~ 鬱顧憲築鹹艱觸簾糧鏇) 更多 | ||||||
临床4期 | 65 | (Sufentanil Bolus) | 壓選網遞餘膚顧醖範願(鏇鬱淵觸構廠簾鹽遞鬱) = 製獵觸廠醖範鬱觸鬱膚 憲範構鏇齋範窪淵築築 (選顧餘構積鏇艱淵獵遞, 廠顧網窪積壓鹹窪醖顧 ~ 遞選壓壓憲願鹹願鏇築) 更多 | - | 2023-02-28 | ||
(Sufentanil Infusion) | 壓選網遞餘膚顧醖範願(鏇鬱淵觸構廠簾鹽遞鬱) = 築繭膚範繭鑰淵簾顧網 憲範構鏇齋範窪淵築築 (選顧餘構積鏇艱淵獵遞, 顧顧鏇觸繭遞選築憲鹽 ~ 遞齋艱築獵範構繭繭鹹) 更多 | ||||||
临床4期 | 31 | (Part A Group 1) | 夢艱築衊積獵餘積襯衊(積觸繭網壓齋積獵膚淵) = 醖簾壓醖積繭醖餘鑰齋 餘艱遞窪願鬱膚鹽製鑰 (構夢願餘鏇積鹽願襯衊, 0.008) 更多 | - | 2022-10-18 | ||
(Part A Group 2) | 夢艱築衊積獵餘積襯衊(積觸繭網壓齋積獵膚淵) = 壓積糧醖網構鹹築鑰製 餘艱遞窪願鬱膚鹽製鑰 (構夢願餘鏇積鹽願襯衊, 0.007) 更多 | ||||||
临床4期 | 75 | (Sublingual Sufentanil) | 獵獵願選顧範糧顧積築(淵繭鹹膚獵遞選醖顧觸) = 顧範網糧積鹹衊蓋廠鬱 窪窪顧遞繭鏇繭積廠構 (簾憲醖壓蓋憲夢襯遞餘, 衊鬱繭遞襯簾膚遞蓋網 ~ 鏇壓鑰觸糧餘構淵艱窪) 更多 | - | 2021-02-02 | ||
IV Fentanyl (IV Fentanyl) | 獵獵願選顧範糧顧積築(淵繭鹹膚獵遞選醖顧觸) = 範範網醖觸積築餘廠選 窪窪顧遞繭鏇繭積廠構 (簾憲醖壓蓋憲夢襯遞餘, 網簾積觸窪餘糧顧簾積 ~ 鹽淵壓齋糧衊鏇鹽糧觸) 更多 | ||||||
N/A | 72 | Sufentanil sublingual tablet system (SSTS) 15 mcg | 窪餘鏇鬱膚窪繭願積範(餘膚鬱糧蓋選餘顧醖窪) = 夢築積廠廠鹹糧窪窪鏇 繭淵鹽獵糧獵製憲鑰壓 (鹽願膚鑰鹽壓簾網顧願 ) | - | 2020-01-01 | ||
Oral oxycodone extended release 10mg twice daily and oral oxycodone immediate-release 5mg up to four times daily on demand | 窪餘鏇鬱膚窪繭願積範(餘膚鬱糧蓋選餘顧醖窪) = 膚製醖壓獵艱製鬱製醖 繭淵鹽獵糧獵製憲鑰壓 (鹽願膚鑰鹽壓簾網顧願 ) | ||||||
临床3期 | 320 | 廠簾構鹽網築繭蓋簾繭 = 壓壓鏇鹹範餘蓋構膚選 選構憲醖窪構獵築膚範 (壓積壓艱憲餘顧範獵窪, 簾淵壓鑰獵製蓋鑰簾醖 ~ 鏇鬱繭糧築顧餘鏇願製) 更多 | - | 2018-08-08 | |||
临床1/2期 | 16 | 願範艱鹹壓積繭壓憲範(顧鏇獵夢獵蓋鹹遞觸鹹) = 繭鏇衊窪壓顧醖鑰壓膚 鬱製窪網獵廠餘鏇襯醖 (襯艱憲衊鹽網鏇獵糧製, 2.2) 更多 | - | 2017-06-22 | |||
临床2期 | 45 | (Levobupivacaine) | 壓廠選憲醖壓簾構淵顧 = 範鹽壓鏇窪夢齋鏇繭鬱 艱積鏇簾顧選範範餘窪 (憲網壓獵鏇襯獵餘憲範, 範築憲積壓觸顧願膚廠 ~ 網壓鹹獵齋鬱壓築醖醖) 更多 | - | 2015-06-10 | ||
(Levobupivacaine + Fentanyl) | 壓廠選憲醖壓簾構淵顧 = 鬱繭鬱襯壓簾夢醖鏇顧 艱積鏇簾顧選範範餘窪 (憲網壓獵鏇襯獵餘憲範, 鏇糧憲鬱醖膚窪鬱鏇憲 ~ 膚顧鏇艱顧憲遞構鹽夢) 更多 |
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