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更新于：2025-12-09
Terbinafine Hydrochloride
盐酸特比萘芬
更新于：2025-12-09
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 美国 (1992-12-30), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C21H26ClN |
InChIKeyBWMISRWJRUSYEX-SZKNIZGXSA-N |
CAS号78628-80-5 |
关联
85
项与 盐酸特比萘芬 相关的临床试验CTRI/2025/10/096590
A Randomized, Parallel Group, Open Label, Active Controlled Clinical Study To Evaluate The Safety And Efficacy Of A Unani Formulation (Topical) Compared With Terbinafine (Topical) In The Management Of Quba (Tinea Corporis And Tinea Cruris) - NIL
ChiCTR2500113562
ED95 of Tegafur-5-Fluorouracil and Rimaclazol for respiratory depression during painless gastroscopy
NCT07152327
Effectiveness of Terbinafine Hydrochloride in the Treatment of Otomycosis: Basic and Clinical Evaluation
100 项与 盐酸特比萘芬 相关的临床结果
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100 项与 盐酸特比萘芬 相关的转化医学
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100 项与 盐酸特比萘芬 相关的专利（医药）
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2,003
项与 盐酸特比萘芬 相关的文献（医药）2025-12-31JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Hidden targets in dermatology:
In vitro
and
In silico
inhibitory effects of common 23 dermatologic drugs on human carbonic anhydrase isoenzymes I and II
Article
作者: Uslu, Harun ; Çıkrıkcı, Kübra ; Can, İlkay ; Gençer, Nahit
In this study, we have aimed to determine the in vitro and in silico effects of 23 frequently used dermatologic drugs on human carbonic anhydrase I (hCA I) and II (hCA II). The inhibitory effects of the drugs on hCA I and hCA II were determined by esterase methods. The most potent inhibitors were isotretinoin for hCA I (Ki= 5.75 µM) and valaciclovir for hCA II (Ki= 5.74 µM). Ketotifen (Ki= 6.98 µM), pantoprazole (Ki= 7.16 µM) and acyclovir (Ki= 7.31 µM) were also potent inhibitors for hCA I. Isotretinoin (Ki= 6.54 µM), brivudine (Ki= 7.44 µM) and fluconazole (Ki= 7.91 µM) were also potent inhibitors for hCA II. Terbinafine hydrochloride was a weak CA inhibitor for both of these isoenzymes (Ki= 20.58 µM for hCA I and 20.32 µM for hCA I). Therefore, the drug, having a weak CA inhibitory activity, may be preferred primarily in patients with a skin disease compared to the other drugs due to important physiological functions of CAs. Molecular docking studies have shown that acitretin and isotretinoin, in particular, will inhibit hCA I at lower concentrations and have higher docking scores. For hCA II, it was shown that Isotretinoin and Ketotifen would inhibit at lower concentrations and have higher placement scores.
2025-12-06JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
Comparison of permeability of topical Cream drug through polymer synthetic membranes of different structures using Franz Cell diffusion test
作者: Güleli, Müge ; Torlak, Cihan ; Kurşun Baysak, Fatma ; Kızılok, Şevki ; Çalışkan, Cem ; Kartop, Remziye Azra
In this study, in-vitro release experiments were performed using a Franz Diffusion Cell system for Terbinafine Hydrochloride, which is used in the treatment of various fungal infections in the skin caused by many susceptible dermatophytes.In order to evaluate TH transdermally, it was aimed to compare the permeability between polymeric membranes synthesized with polyvinyl alc. and chitosan mixtures and com. membranes.In the transdermal drug delivery system calculations, the Fick Diffusion Law was modified and the obtained data were compared.The study was evaluated according to the USP <1724> topical drug products in semisolid form - performance tests.A new high-performance liquid chromatog. method was validated for the assay of TH released into the receptor medium in accordance with the ICH guideline.According to the results obtained during the validation process, the limit of detection value was calculated as 0.005 μg/mL and the limit of quantification value was 0.013 μg/mL.Since polymer-based synthetic membranes provide permeability according to mol. size, properties and the ideal environment for measuring and analyzing the diffusion rate of a compound, in experiments conducted using membranes of different structures, the permeability profiles of selected polymer synthetic membranes were statistically evaluated.It has been noted that the hydroxyl groups in PVA and the hydrophilic CS-g-PNDMAAm graft copolymer act at varying rates to enhance or reduce the permeability across the membrane by promoting its diffusion.NaY zeolite has been shown to function as an adsorbent against the medication, lessening the impact of hydrophilic PVA without supplying permeability.
2025-11-02Expert Opinion On Drug Safety
Drug-induced erectile dysfunction: a real-world pharmacovigilance study using the FDA adverse event reporting system database
Article
作者: Zhang, Rui ; Li, Dongxuan ; Du, Qian ; Zhu, Jun ; Wang, Yalan ; Dai, Liyang ; Liu, Songqing ; Wu, Fan ; Zhang, Tongyan
BACKGROUND:
The comprehensive quantitative and comparative risk data of drug-induced erectile dysfunction (ED) are still lacking, and this study aims to supplement this information.
RESEARCH DESIGN AND METHODS:
We reviewed all the ED reports in the FDA Adverse Event Reporting System (FAERS) database from 2004 to 2023 and summarized a potential ED culprit-drug list and its corresponding reporting frequency. The reporting odds ratio (ROR) method was used to conduct disproportionality analysis.
RESULTS:
A total of 20,098 ED reports were retrieved from the FAERS database, which recorded 734 different ED culprit-drugs, involving 74 drug classes. Finasteride was the drug with the highest reporting frequency, and urologicals was the drug class with the highest reporting frequency. In disproportionality analysis, 209 drugs with positive signals showed a close relationship with ED occurrence, among which finasteride was the drug with the highest signal strength. Among 209 drugs with positive signals, 27 were compound preparations, and the risk level of compound preparations was usually higher than their single active ingredient.
CONCLUSIONS:
Our study integrated quantitative and comparative ED risk data of 734 drugs by using the FAERS database, which can provide reference information for regulators, medical personnel, and others involved in drug management and use.
100 项与 盐酸特比萘芬 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 甲癣 | 澳大利亚 | 2003-12-22 | |
| 体癣 | 澳大利亚 | 2003-12-22 | |
| 股癣 | 澳大利亚 | 2003-12-22 | |
| 足癣 | 美国 | 1999-03-09 | |
| 皮肤真菌病 | 中国 | 1997-01-01 | |
| 皮肤念珠菌病 | 日本 | 1993-07-02 | |
| 真菌病 | 日本 | 1993-07-02 | |
| 癣 | 日本 | 1993-07-02 | |
| 花斑癣 | 日本 | 1993-07-02 | |
| 头癣 | 美国 | 1992-12-30 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 红斑 | 临床1期 | 美国 | 2017-10-15 | |
| 粘膜念珠菌病 | 临床阶段不明 | 美国 | 2001-08-31 | |
| 口腔念珠菌病 | 临床阶段不明 | 美国 | 2001-08-31 | |
| HIV感染 | 临床阶段不明 | 美国 | 2001-08-31 |
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临床3期 | 384 | 願餘鏇齋鏇艱淵淵膚艱(積艱壓醖遞構網築衊積) = 艱鏇網築顧簾艱遞淵鹽 構鹽廠觸構遞願鹹艱積 (獵廠鏇繭齋範製網淵築 ) 更多 | 不佳 | 2025-01-10 | |||
临床1期 | 20 | 膚選觸夢襯鑰範獵網夢(願範範襯衊淵醖顧範鏇) = Adverse events (five patients), such as headache (n = 3), seasonal allergy (n = 1), and neck pain (n = 1), were considered unrelated to MOB015B; no application site reactions or study discontinuations due to an adverse event were observed. 蓋鹽鏇艱鹽鹹鹽遞選憲 (觸鑰艱築廠範醖繭襯醖 ) | 积极 | 2024-08-19 | |||
临床3期 | - | 鬱夢遞艱憲願夢壓築鹽(顧簾窪襯鏇網網積網願) = 襯膚網鏇築鬱鏇鹹鑰鬱 範願鬱顧築網餘顧衊構 (齋鑰糧鑰窪範鑰壓衊鹽 ) 更多 | 非优 | 2021-07-01 | |||
vehicle | 鬱夢遞艱憲願夢壓築鹽(顧簾窪襯鏇網網積網願) = 觸窪窪襯鏇網鹽網壓蓋 範願鬱顧築網餘顧衊構 (齋鑰糧鑰窪範鑰壓衊鹽 ) 更多 | ||||||
临床3期 | 452 | 鏇顧壓壓遞齋獵鑰衊糧(網鑰襯顧壓壓鹽鬱鬱觸) = 鏇膚衊鏇範糧壓膚製顧 願艱選壓觸鬱鏇餘襯憲 (築觸獵製構壓選製願醖 ) 更多 | 非劣 | 2020-06-25 | |||
鏇顧壓壓遞齋獵鑰衊糧(網鑰襯顧壓壓鹽鬱鬱觸) = 淵獵淵繭廠鏇範餘衊廠 願艱選壓觸鬱鏇餘襯憲 (築觸獵製構壓選製願醖 ) 更多 |
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