A Phase 1 Study of Fosbretabulin in Combination With Everolimus in Neuroendocrine Tumors (Grades 1-3) That Have Progressed After at Least One Prior Regimen for Metastatic Disease

This is a single center, open label, phase I study involving grade I-III gastroenteropancreatic neuroendocrine tumors, consisting of a dose escalation Part A followed by an expansion cohort Part B. On Part A Patients will be treated with daily oral everolimus. Fosbretabulin will be administered IV either q3 weekly or q weekly based on PO CRM cohort. Part B: Once the investigators have established an MTD in Part A, the investigators will be treating 15 more patients at that dose combination. The primary and secondary objectives of the expansion cohort will be similar to Part A of the study, i.e., to establish a safety profile of the experimental drug combination and to collect and assess efficacy data. Patients will be treated with concurrent everolimus and fosbretabulin for 12 weeks.

开始日期2017-03-06

申办/合作机构

University of Kentucky

NCT01701349 / Withdrawn临床3期

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Fosbretabulin Tromethamine (CA4P) in Combination With Paclitaxel and Carboplatin in Anaplastic Thyroid Carcinoma (FACT2)

This is a multicenter, double-blind, placebo-controlled, randomized study of fosbretabulin given with chemotherapy (paclitaxel and carboplatin) compared to placebo given with chemotherapy (paclitaxel and carboplatin) in subjects with anaplastic thyroid cancer (ATC). The primary objective of the study is to determine overall survival. A maximum of 300 subjects will be recruited from approximately 75 multinational sites of which approximately 35 will be located in the United States.

开始日期2015-03-01

申办/合作机构

Oncotelic Therapeutics, Inc.

NCT02279602 / Completed临床2期

Rollover for Study OX4218s, A P2 Study to Investigate Safety and Activity of Fosbretabulin Tromethamine in the Treatment of Well-Differentiated, Low-to-Intermediate-Grade Unresectable, Recurrent or Metastatic PNET or GI-NET With Elevated Biomarkers

Subjects achieving a clinical response in study OX4218s with a biomarker reduction or symptom response are eligible to enroll in this rollover study to continue once every three weeks fosbretabulin infusions for up to one year.

开始日期2014-12-01

申办/合作机构

Oncotelic Therapeutics, Inc.

100 项与康普瑞丁磷酸二钠相关的临床结果

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100 项与康普瑞丁磷酸二钠相关的转化医学

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100 项与康普瑞丁磷酸二钠相关的专利（医药）

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765

项与康普瑞丁磷酸二钠相关的文献（医药）

2025-01-01·European Journal of Medicinal Chemistry

A novel life for antitumor combretastatins: Recent developments of hybrids, prodrugs, combination therapies, and antibody-drug conjugates

Review

作者: Ammazzalorso, Alessandra ; Amoroso, Rosa ; De Filippis, Barbara ; Fantacuzzi, Marialuigia ; Maccallini, Cristina ; Giampietro, Letizia ; Carradori, Simone

Since their discovery from natural sources, the potent cytotoxic effects of combretastatins were widely studied for the application in antitumor therapy. However, major pharmacokinetic issues as low water solubility and chemical instability of the double bond configuration prevented their use in therapy. A lot of efforts have been directed towards the search of novel strategies, allowing a safer use of combretastatins as anticancer agents. This review analyses the recent landscape in combretastatin research, characterized by the identification of hybrids, prodrugs, and novel combination treatments. Interestingly, the potent cytotoxic agent combretastatin A4 (CA4) was recently proposed as payload in the construction of novel antibody-drug conjugates (ADCs), allowing an efficient targeting of the cytotoxic agent to specific tumors.

2024-08-07·ACS Applied Materials & Interfaces

Peptide-IR820 Conjugate: A Promising Strategy for Efficient Vascular Disruption and Hypoxia Induction in Melanoma

Article

作者: Li, Gongyu ; Zheng, Zhen ; Zhang, Hongxia ; Zhao, Rui ; Jiang, Mengmeng ; Xing, Weiyu

Photothermal therapy (PTT) has emerged as a noninvasive and precise cancer treatment modality known for its high selectivity and lack of drug resistance. However, the clinical translation of many PTT agents is hindered by the limited biodegradability of inorganic nanoparticles and the instability of organic dyes. In this study, a peptide conjugate, IR820-Cys-Trp-Glu-Trp-Thr-Trp-Tyr (IR820-C), was designed to self-assemble into nanoparticles for both potent PTT and vascular disruption in melanoma treatment. When co-assembled with the poorly soluble vascular disrupting agent (VDA) combretastatin A4 (CA4), the resulting nanoparticles (IR820-C@CA4 NPs) accumulate efficiently in tumors, activate systemic antitumor immune responses, and effectively ablate melanoma with a single treatment and near-infrared irradiation, as confirmed by our in vivo experiments. Furthermore, by exploiting the resulting tumor hypoxia, we subsequently administered the hypoxia-activated prodrug tirapazamine (TPZ) to capitalize on the created microenvironment, thereby boosting therapeutic efficacy and antimetastatic potential. This study showcases the potential of short-peptide-based nanocarriers for the design and development of stable and efficient photothermal platforms. The multifaceted therapeutic strategy, which merges photothermal ablation with vascular disruption and hypoxia-activated chemotherapy, holds great promise for advancing the efficacy and scope of cancer treatment modalities.

2024-06-01·Investigational New Drugs

In vitro results with minimal blood toxicity of a combretastatin A4 analogue

Article

作者: Petri, Giuliana ; Lima, Lídia Moreira ; Britos, Tatiane Nassar ; Barreiro, Eliezer J ; Fonseca, Fernando Luiz Affonso ; Ferreira, Fabio Furlan ; Chagas, Camila ; Mansano, Jaqueline Vital ; Schumacher, Maria Lúcia ; Pereira, Edimar Cristiano ; da Silva, Emerson Barbosa ; Haddad, Paula Silvia ; da Costa Aguiar Alves Reis, Beatriz

Cancer is a disease caused by uncontrolled cell growth that is responsible for several deaths worldwide. Breast cancer is the most common type of cancer among women and is the leading cause of death. Chemotherapy is the most commonly used treatment for cancer; however, it often causes various side effects in patients. In this study, we evaluate the antineoplastic activity of a parent compound based on a combretastatin A4 analogue. We test the compound at 0.01 mg mL^- 1, 0.1 mg mL^- 1, 1.0 mg mL^- 1, 10.0 mg mL^- 1, 100.0 mg mL^- 1, and 1,000.0 mg mL^- 1. To assess molecular antineoplastic activity, we conduct in vitro tests to determine the viability of Ehrlich cells and the blood mononuclear fraction. We also analyze the cytotoxic behavior of the compound in the blood and blood smear. The results show that the molecule has a promising antineoplastic effect and crucial anticarcinogenic action. The toxicity of blood cells does not show statistically significant changes.

项与康普瑞丁磷酸二钠相关的新闻（医药）

2024-11-06

·GlobeNewswire-Health Care

ONCOTELIC CLINICAL PRESENTATIONS AT SITC 2024

AGOURA HILLS, Calif., Nov. 06, 2024 (GLOBE NEWSWIRE) -- Oncotelic Therapeutics, Inc (OTCQB:OTLC) announced today its presentation at SITC 2024. Dr. Cynthia Lee, VP of R&D will be presenting Sapu Bio pipeline of TGFB2 therapeutics. For additional information please go to: https://www.sitcancer.org/home. Dr. Lee has been leading our R&D programs for the past several years including the buildout of our GMP facility in San Diego. The presentations are: Abstract Number 198: TGFB2 mRNA levels prognostically interact with Interferon-alpha receptor activation of IRF9 and IFI27, and makers for tumor-associated macrophages impacting overall survival in PDAC. Authors Sanjive Qazi, Cynthia Lee, Vuong Trieu Abstract Number 218: Evaluating the prognostic impact of Transforming growth factor beta 2 mRNA levels, in conjunction with Interferon-gamma receptor activation of IRF5 and expression of CD276/B7-H3 in low-grade gliomas. Authors Sanjive Qazi, Anthony Maida, Vuong Trieu Abstract Number 1444: Meta-analysis comparing the incidence of serious adverse events, overall survival, and progression-free survival in PDAC patients harboring unresectable tumors treated with mFOLFIRINOX or FOLFIRINOX. Authors Vuong Trieu, Sanjive Qazi, Seymour Fein, Anthony Maida, Tenshang Joh About Oncotelic Oncotelic has rare pediatric designation for Diffuse Intrinsic Pontine Glioma (“DIPG” through OT-101) through its 45% joint venture, GMP Biotechnology Limited, melanoma (through CA4P), and Acute Myeloid Leukemia (through OXi 4503). Oncotelic acquired PointR Data Inc. in November 2019 to build an AI driven biotechnology company. Further, Oncotelic acquired AL-101, during the 4th quarter of 2021, for the intranasal delivery of apomorphine. We intend to develop AL-101 for the treatment of Parkinson Disease, erectile dysfunction, female sexual disorder and hypoactive sexual desire disorder. All these ailments have a very large population suffering from them and there is a need for treatments for each. Oncotelic’s first in class TGFB2 therapeutic to treat pancreatic cancer and glioblastoma is being developed through its JV – Sapu Bio. Oncotelic's Cautionary Note on Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical facts, included in this communication regarding strategy, future operations, future financial position, prospects, plans and objectives of management are forward-looking statements. Words such as "may", "expect", "anticipate" "hope", "vision", "optimism", "design", "exciting", "promising", "will", "conviction", "estimate," "intend," "believe", "quest for a cure of cancer", "innovation-driven", "paradigm-shift", "high scientific merit", "impact potential" and similar expressions are intended to identify forward-looking statements. Forward looking statements contained in this press release include, but are not limited to, statements about future plans related to the operations of the JV, taking the JV into an initial public offering or the success thereof, the progress, timing of clinical development, scope and success of future clinical trials, the reporting of clinical data for the Company’s product candidates and the potential use of the Company's product candidates to treat various cancer indications as well as obtaining required regulatory approval to conduct clinical trials and upon granting of approval by the regulatory agencies, the successful marketing of the products; building and the success of our nanoparticle platform and the related success of launching the platform, the development of the Company’s AI suite including but not limited to AI Chatbots, the public access to the Company’s AI suite, the success of the development of the AI suite or any other AI technologies and whether if any or portion thereof the Company’s AI suite or technologies will be commercialized and launched for sale. Each of these forward-looking statements involves risks and uncertainties, and actual results may differ materially from these forward-looking statements or may not occur at all. Many factors may cause differences between current expectations and actual results, including unexpected safety or efficacy data observed during preclinical or clinical studies, clinical trial site activation or enrollment rates that are lower than expected, changes in expected or existing competition, changes in the regulatory environment, failure of collaborators to support or advance collaborations or product candidates and unexpected litigation or other disputes, taking the Company or its affiliates through initial public offerings. These risks are not exhaustive, the company faces known and unknown risks, including the risk factors described in the Company's Annual Report on Form 10-K/A filed with the SEC on April 19, 2023 and in the company's other periodic filings. Forward-looking statements are based on expectations and assumptions as of the date of this press release. Except as required by law, the company does not assume any obligation to update forward-looking statements contained herein to reflect any change in expectations, whether because of new information, future events, or otherwise. Contact Information: For Oncotelic Therapeutics, Inc.:Investor Relationsir@oncotelic.com

并购信使RNA

2024-10-28

·GlobeNewswire-Health Care

ONCOTELIC PUBLISHED ITS FOURTH PUBLICATION ON TGFB2 THERAPEUTICS

AGOURA HILLS, Calif., Oct. 28, 2024 (GLOBE NEWSWIRE) -- Oncotelic Therapeutics, Inc (OTCQB:OTLC) announced today its fourth publication of its TGFB2 series. Clinical data demonstrated that pancreatic cancer patients with high expression levels of either TGFB2, IRF9, or IFI27 showed improvement of median overall survival from 16-20 months to 72 months for patients with low levels of expression for both TGFB2 and either IRF9 or IFI27 validating that knockdown of IRF9 and IFI27 as therapeutic targets for TGFB2 therapeutics. https://www.mdpi.com/3003472 The publications of this series are available at Pubmed as follow: 1) TGFB2 mRNA Levels Prognostically Interact with Interferon-Alpha Receptor Activation of IRF9 and IFI27, and an Immune Checkpoint LGALS9 to Impact Overall Survival in Pancreatic Ductal Adenocarcinoma. Qazi S, Trieu V. Int J Mol Sci. 2024 Oct 18;25(20):11221. doi: 10.3390/ijms252011221. PMID: 39457004 2) Transforming Growth Factor Beta 2 (TGFB2) mRNA Levels, in Conjunction with Interferon-Gamma Receptor Activation of Interferon Regulatory Factor 5 (IRF5) and Expression of CD276/B7-H3, Are Therapeutically Targetable Negative Prognostic Markers in Low-Grade Gliomas. Trieu V, Maida AE, Qazi S. Cancers (Basel). 2024 Mar 19;16(6):1202. doi: 10.3390/cancers16061202. PMID: 38539537 Free PMC article. 3) Transforming Growth Factor Beta 2 (TGFB2) and Interferon Gamma Receptor 2 (IFNGR2) mRNA Levels in the Brainstem Tumor Microenvironment (TME) Significantly Impact Overall Survival in Pediatric DMG Patients. Qazi S, Talebi Z, Trieu V. Biomedicines. 2024 Jan 15;12(1):191. doi: 10.3390/biomedicines12010191. PMID: 38255296 Free PMC article. 4) High Intra-Tumor Transforming Growth Factor Beta 2 Level as a Predictor of Poor Treatment Outcomes in Pediatric Diffuse Intrinsic Pontine Glioma. Uckun FM, Qazi S, Trieu V. Cancers (Basel). 2023 Mar 9;15(6):1676. doi: 10.3390/cancers15061676. PMID: 36980562 Free PMC article. Additional information on our current phase 3 can be found at: https://www.youtube.com/watch?v=5KqdbySDRKE About Oncotelic Oncotelic (f/k/a Mateon Therapeutics, Inc.), was formed in the State of New York in 1988 as OXiGENE, Inc., was reincorporated in the State of Delaware in 1992, and changed its name to Mateon Therapeutics, Inc. in 2016, and Oncotelic Therapeutics, Inc. in November 2020. Oncotelic is seeking to leverage its deep expertise in oncology drug development to improve treatment outcomes and survival of cancer patients with a special emphasis on rare pediatric cancers. Oncotelic has rare pediatric designation for Diffuse Intrinsic Pontine Glioma (“DIPG” through OT-101) through its 45% joint venture, GMP Biotechnology Limited, melanoma (through CA4P), and Acute Myeloid Leukemia (through OXi 4503). Oncotelic acquired PointR Data Inc. in November 2019 to build an AI driven biotechnology company. Further, Oncotelic acquired AL-101, during the 4th quarter of 2021, for the intranasal delivery of apomorphine. We intend to develop AL-101 for the treatment of Parkinson Disease, erectile dysfunction, female sexual disorder and hypoactive sexual desire disorder. All these ailments have a very large population suffering from them and there is a need for treatments for each. For more information on AL-101, refer to our Annual Report on Form 10-K/A filed with the SEC on April 19, 2023. Oncotelic's Cautionary Note on Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical facts, included in this communication regarding strategy, future operations, future financial position, prospects, plans and objectives of management are forward-looking statements. Words such as "may", "expect", "anticipate" "hope", "vision", "optimism", "design", "exciting", "promising", "will", "conviction", "estimate," "intend," "believe", "quest for a cure of cancer", "innovation-driven", "paradigm-shift", "high scientific merit", "impact potential" and similar expressions are intended to identify forward-looking statements. Forward looking statements contained in this press release include, but are not limited to, statements about future plans related to the operations of the JV, taking the JV into an initial public offering or the success thereof, the progress, timing of clinical development, scope and success of future clinical trials, the reporting of clinical data for the Company’s product candidates and the potential use of the Company's product candidates to treat various cancer indications as well as obtaining required regulatory approval to conduct clinical trials and upon granting of approval by the regulatory agencies, the successful marketing of the products; building and the success of our nanoparticle platform and the related success of launching the platform, the development of the Company’s AI suite including but not limited to AI Chatbots, the public access to the Company’s AI suite, the success of the development of the AI suite or any other AI technologies and whether if any or portion thereof the Company’s AI suite or technologies will be commercialized and launched for sale. Each of these forward-looking statements involves risks and uncertainties, and actual results may differ materially from these forward-looking statements or may not occur at all. Many factors may cause differences between current expectations and actual results, including unexpected safety or efficacy data observed during preclinical or clinical studies, clinical trial site activation or enrollment rates that are lower than expected, changes in expected or existing competition, changes in the regulatory environment, failure of collaborators to support or advance collaborations or product candidates and unexpected litigation or other disputes, taking the Company or its affiliates through initial public offerings. These risks are not exhaustive, the company faces known and unknown risks, including the risk factors described in the Company's Annual Report on Form 10-K/A filed with the SEC on April 19, 2023 and in the company's other periodic filings. Forward-looking statements are based on expectations and assumptions as of the date of this press release. Except as required by law, the company does not assume any obligation to update forward-looking statements contained herein to reflect any change in expectations, whether because of new information, future events, or otherwise. Contact Information: For Oncotelic Therapeutics, Inc.:Investor Relationsir@oncotelic.com

并购临床3期

2024-10-23

·GlobeNewswire-Health Care

ONCOTELIC PRESENTATION AT PRECISION IN DRUG DISCOVERY & PRECLINICAL SUMMIT SAN DIEGO 2024

AGOURA HILLS, Calif., Oct. 23, 2024 (GLOBE NEWSWIRE) -- Oncotelic Therapeutics, Inc (OTCQB:OTLC) announced today its presentation at Precision in Drug Discovery & Preclinical Summit. Dr. Wen-Han Chang, Nanomedicine Sr. Manager, and Dr. Tara Zand, Research Scientist, presented Sapu Bio pipeline of TGFB2 therapeutics. For additional information please go to: https://events.precision-globe.com/single-event/precision-drug-discovery-preclinical-summit-san-diego##. Dr. Chang and Dr. Zand are experienced nanomedicine and precision drug development dedicated to finding the cure for pancreatic and brain cancers. https://www.linkedin.com/in/wen-han-chang-106002139/ https://www.linkedin.com/in/tara-zand-phd-512042b5/ https://www.linkedin.com/posts/precision-evolution-global-inc_pddpsummit-sandiego-precisionevolutionglobal-activity-7253106596543619072-IqP5/ About Oncotelic Oncotelic (f/k/a Mateon Therapeutics, Inc.), was formed in the State of New York in 1988 as OXiGENE, Inc., was reincorporated in the State of Delaware in 1992, and changed its name to Mateon Therapeutics, Inc. in 2016, and Oncotelic Therapeutics, Inc. in November 2020. Oncotelic is seeking to leverage its deep expertise in oncology drug development to improve treatment outcomes and survival of cancer patients with a special emphasis on rare pediatric cancers. Oncotelic has rare pediatric designation for Diffuse Intrinsic Pontine Glioma (“DIPG” through OT-101) through its 45% joint venture, GMP Biotechnology Limited, melanoma (through CA4P), and Acute Myeloid Leukemia (through OXi 4503). Oncotelic acquired PointR Data Inc. in November 2019 to build an AI driven biotechnology company. Further, Oncotelic acquired AL-101, during the 4th quarter of 2021, for the intranasal delivery of apomorphine. We intend to develop AL-101 for the treatment of Parkinson Disease, erectile dysfunction, female sexual disorder and hypoactive sexual desire disorder. All these ailments have a very large population suffering from them and there is a need for treatments for each. For more information on AL-101, refer to our Annual Report on Form 10-K/A filed with the SEC on April 19, 2023. Oncotelic's Cautionary Note on Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical facts, included in this communication regarding strategy, future operations, future financial position, prospects, plans and objectives of management are forward-looking statements. Words such as "may", "expect", "anticipate" "hope", "vision", "optimism", "design", "exciting", "promising", "will", "conviction", "estimate," "intend," "believe", "quest for a cure of cancer", "innovation-driven", "paradigm-shift", "high scientific merit", "impact potential" and similar expressions are intended to identify forward-looking statements. Forward looking statements contained in this press release include, but are not limited to, statements about future plans related to the operations of the JV, taking the JV into an initial public offering or the success thereof, the progress, timing of clinical development, scope and success of future clinical trials, the reporting of clinical data for the Company’s product candidates and the potential use of the Company's product candidates to treat various cancer indications as well as obtaining required regulatory approval to conduct clinical trials and upon granting of approval by the regulatory agencies, the successful marketing of the products; building and the success of our nanoparticle platform and the related success of launching the platform, the development of the Company’s AI suite including but not limited to AI Chatbots, the public access to the Company’s AI suite, the success of the development of the AI suite or any other AI technologies and whether if any or portion thereof the Company’s AI suite or technologies will be commercialized and launched for sale. Each of these forward-looking statements involves risks and uncertainties, and actual results may differ materially from these forward-looking statements or may not occur at all. Many factors may cause differences between current expectations and actual results, including unexpected safety or efficacy data observed during preclinical or clinical studies, clinical trial site activation or enrollment rates that are lower than expected, changes in expected or existing competition, changes in the regulatory environment, failure of collaborators to support or advance collaborations or product candidates and unexpected litigation or other disputes, taking the Company or its affiliates through initial public offerings. These risks are not exhaustive, the company faces known and unknown risks, including the risk factors described in the Company's Annual Report on Form 10-K/A filed with the SEC on April 19, 2023 and in the company's other periodic filings. Forward-looking statements are based on expectations and assumptions as of the date of this press release. Except as required by law, the company does not assume any obligation to update forward-looking statements contained herein to reflect any change in expectations, whether because of new information, future events, or otherwise. Contact Information: For Oncotelic Therapeutics, Inc.:Investor Relationsir@oncotelic.com

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100 项与康普瑞丁磷酸二钠相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	康普瑞丁磷酸二钠	-	DB12577

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
甲状腺未分化癌	临床1期	英国	Oncotelic Therapeutics, Inc.	2007-08-01
甲状腺未分化癌	临床1期	以色列	Oncotelic Therapeutics, Inc.	2007-08-01
甲状腺未分化癌	临床1期	美国	Oncotelic Therapeutics, Inc.	2007-08-01
甲状腺未分化癌	临床1期	意大利	Oncotelic Therapeutics, Inc.	2007-08-01
甲状腺未分化癌	临床1期	俄罗斯	Oncotelic Therapeutics, Inc.	2007-08-01
卵巢癌	临床1期	-	Azanta A/S	-
晚期恶性实体瘤	临床前	美国	Oncotelic Therapeutics, Inc.	2005-03-01
脉络膜新生血管	临床前	-	Oncotelic Therapeutics, Inc.	2005-03-01
输卵管癌	药物发现	-	Azanta A/S	-
卵巢癌	药物发现	-	Azanta A/S	-

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临床结果

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02055690 (PAZOFOS, Pubmed \| Obstet Gynecol Surv) 人工标引	临床2期	复发性卵巢癌	21	Pazopanib+Fosbretabulin	(淵襯壓選膚積製艱膚簾) = 願襯艱艱選遞糧繭憲糧網壓構積醖範蓋製壓繭 (憲齋鹽淵衊觸壓範簾網, 4.1 ~ NE)	积极	2020-03-01
				Pazopanib	(淵襯壓選膚積製艱膚簾) = 觸繭憲艱衊淵廠壓膚獵網壓構積醖範蓋製壓繭 (憲齋鹽淵衊觸壓範簾網, 1.0 ~ 8.1)
EUCTR2013-005471-40-GB (ESMO2018)	临床2期	复发性卵巢癌	-	Fosbretabulin 54mg/m2 + Pazopanib 600mg/day	憲齋鹹窪願願襯築齋憲(獵範窪衊餘艱壓鹽鏇鹹) = Four patients who received F+P (2 in P1b and 2 in RP2) developed acute hypertension plus reversible secondary cardiac toxicity. The occurrence of cardiac toxicity resulted in premature discontinuation of the trial. 衊衊膚積繭糧夢積艱鏇 (選願鏇廠積餘鬱憲餘簾 ) 更多	积极	2018-10-20
				Pazopanib 800mg/day
NCT02279602 (OX4219 \| OX4219s, Corporate Publications) 人工标引	临床2期	神经内分泌肿瘤 \| 胃肠道肿瘤	7	Disodium combretastatin A-4 3-O-Phosphate	(淵齋觸觸範鹽夢鏇遞獵) = anemia, abdominal pain, fatigue, hypertension, and ALT and AST increases 鬱選襯網顧築艱獵憲築 (繭製遞憲齋網鹽範獵簾 ) 更多	积极	2017-01-20
NCT00653939 (FALCON, CTgov)	临床2期	鳞状非小细胞肺癌	63	carboplatin+Paclitaxel+Bevacizumab (Arm 1: Chemotherapy+Bevacizumab)	鏇窪網顧糧餘鬱衊遞網(餘簾築壓醖鑰願獵遞膚) = 艱憲獵糧醖齋構艱餘製顧鑰壓蓋獵構築鹽選鏇 (齋簾糧網鹹遞鬱衊築願, 鹹淵醖蓋製夢窪積襯網 ~ 構築範憲窪構獵構願選) 更多	-	2015-02-09
				carboplatin+Paclitaxel+Bevacizumab+Fosbretabulin (Arm 2: Active Comparator+Fosbretabulin)	鏇窪網顧糧餘鬱衊遞網(餘簾築壓醖鑰願獵遞膚) = 願廠憲夢遞夢鑰鏇積醖顧鑰壓蓋獵構築鹽選鏇 (齋簾糧網鹹遞鬱衊築願, 蓋齋鹹艱簾範簾膚廠壓 ~ 淵餘廠膚願鏇顧遞繭蓋) 更多
NCT00507429 (FACT, CTgov)	临床2/3期	甲状腺未分化癌	80	Carboplatin+Paclitaxel+CA4P (Arm 1, Active: CA4P + Carboplatin + Paclitaxel)	鬱襯築鹹簾積鬱鹽餘醖(衊選鏇糧積膚醖鏇餘齋) = 窪觸壓艱築簾齋膚憲積鹽壓觸構夢襯憲鏇憲願 (鬱觸蓋願襯壓鑰簾蓋製, 鬱製構餘餘鏇積簾製艱 ~ 襯獵鑰淵夢願襯襯夢鹹) 更多	-	2014-06-09
				Carboplatin+Paclitaxel (Arm 2, Comparator: Carboplatin + Paclitaxel)	鬱襯築鹹簾積鬱鹽餘醖(衊選鏇糧積膚醖鏇餘齋) = 蓋顧簾壓憲鹹醖齋廠餘鹽壓觸構夢襯憲鏇憲願 (鬱觸蓋願襯壓鑰簾蓋製, 夢繭襯構鏇餘淵廠選膚 ~ 淵鹹繭膚壓鏇顧廠簾廠) 更多
FALCON (ASCO2011)	临床2期	非小细胞肺癌	63	CA4P + carboplatin + paclitaxel + bevacizumab	(觸繭夢鬱選齋艱壓網鏇) = more common on the CA4P Arm 襯鬱鑰繭餘夢淵遞鏇餘 (蓋窪網願鑰蓋衊壓窪夢 ) 更多	-	2011-05-20
				carboplatin + paclitaxel + bevacizumab
FACT (ASCO2011)	临床2/3期	BRAF V600E 突变阳性甲状腺未分化癌	80	CA4P + Carboplatin + Paclitaxel	(糧憲選窪構構簾願選顧) = 壓襯範繭廠齋襯鑰遞鏇範繭範鏇糧膚遞淵築餘 (構鏇選衊餘鏇鬱衊淵齋 ) 更多	积极	2011-05-20
				Carboplatin + Paclitaxel	(糧憲選窪構構簾願選顧) = 衊膚繭壓糧選鹹鹽衊鬱範繭範鏇糧膚遞淵築餘 (構鏇選衊餘鏇鬱衊淵齋 ) 更多
FALCON (ASCO2010)	临床2期	非小细胞肺癌	50	CA4PP + C + P + B	(繭構製遞蓋遞襯製憲鑰) = 襯壓蓋鹹簾製製獵廠夢壓壓窪遞淵衊壓蓋餘醖 (製膚築繭淵蓋鹹糧壓繭 ) 更多	积极	2010-05-20
				C + P + B	(繭構製遞蓋遞襯製憲鑰) = 淵衊齋餘觸獵鹽夢鬱繭壓壓窪遞淵衊壓蓋餘醖 (製膚築繭淵蓋鹹糧壓繭 ) 更多
NCT00060242 (Pubmed \| Thyroid)	临床2期	甲状腺未分化癌	26	Fosbretabulin 45 mg/m(2)	糧鏇餘醖憲顧願獵衊選(餘鏇鑰蓋網齋簾齋範簾) = 鬱構醖鑰齋齋築襯願觸製餘積遞糧廠鹹鬱築鏇 (窪繭遞築遞鏇艱積壓艱 ) 更多	-	2009-03-01
NCT00003698 (Pubmed \| J Urol)	临床1期	实体瘤	-	Combretastatin A4 phosphate	(憲構衊淵憲範艱憲壓膚) = 製窪齋鑰蓋獵簾齋簾齋製淵壓憲製願蓋醖膚繭 (淵醖壓選壓膚鑰選壓淵 )	-	2003-08-01