预约演示
更新于：2024-12-24
Desmopressin Acetate
醋酸去氨加压素
更新于：2024-12-24
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1978-02-21), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C48H70N14O15S2 |
InChIKeyKWCKGAOCVGPZIC-VCCVNBJCSA-N |
CAS号62357-86-2 |
Sequence Code 15355219
关联
177
项与 醋酸去氨加压素 相关的临床试验NCT06635629
Phase II Prospective Evaluation of Desmopressin Stimulation Test Performance in ACTH-dependent Cushing s Syndrome
NCT06020495
Systematic Use of DDAVP to Prevent Serum Sodium Overcorrection in Severe Hyponatremia: a Multicenter Open-label Randomized Controlled Trial
NCT06622187
Use of Desmopressin Prior to Graft Kidney Biopsy in Patients with High Risk of Bleeding: a Randomized Clinical Trial
100 项与 醋酸去氨加压素 相关的临床结果
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100 项与 醋酸去氨加压素 相关的转化医学
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100 项与 醋酸去氨加压素 相关的专利（医药）
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5,416
项与 醋酸去氨加压素 相关的文献（医药）2025-12-01CHILDS NERVOUS SYSTEM
Intracranial lobar germinoma presenting with refractory hypernatremia
Article
作者: Saini, Jitender ; Arivazhagan, A ; Sipani, Mahak ; Shashidhar, Abhinith ; Birua, Gyani Jail Singh ; Rao, Shilpa
Central nervous system germ cell tumours are most commonly seen in the midline structures. Eccentric germinomas are rare but can be found in the basal ganglia, lobar, brainstem, and cranial vault. We present a 14-year-old boy who presented with signs and symptoms of overt diabetes insipidus and a radiological diagnosis of left frontal high-grade glioma. Confirmative histopathology revealed germinoma. The patient had a resolution of hypernatremia post-surgery and maintained normal sodium homeostasis on a single dose of 0.1 mg of tablet desmopressin. This paper showcases a rare case of an eccentric central nervous system germinoma in a young male patient presenting with Diabetes Insipidus without any apparent sellar or suprasellar involvement.
2025-01-01Plastic and reconstructive surgery
An Algorithm for Control of Excessive Perioperative Bleeding and Ecchymosis in Rhinoplasty Patients Based on 4 Decades of Experience
Article
作者: Cakmakoglu, Cagri ; Avasarala, Vardhan ; Guyuron, Bahman
Background::
Persistent intraoperative bleeding, excessive postoperative ecchymosis, epistaxis, and blood collection in the supratip area increase the complexity of rhinoplasty, causing suboptimal outcomes. The authors present an intraoperative bleeding management algorithm, developed by the senior author (B.G.) based on 43 years of experience, and assess its efficacy in achieving hemostatic control through 103 consecutive cases.
Methods::
A retrospective chart review was conducted on 103 consecutive patients who had undergone septorhinoplasty performed by a single surgeon. The authors reviewed patient demographics; coagulopathies; medications; diet; intraoperative use of tranexamic acid (TXA), deamino-8-d-arginine vasopressin (DDAVP), and vitamin K; and postoperative complications.
Results::
Twenty-six patients (25.2%) did not receive intraoperative hemostatic agents. Twenty-six patients (25.2%) required TXA only, 3 patients (2.91%) were given DDAVP only, 1 patient (0.97%) received vitamin K only, and 46 patients (44.7%) required both TXA and DDAVP. One patient (0.97%) needed TXA, DDAVP, and vitamin K. Intraoperative bleeding was controlled in all patients. One patient with known factor 11 deficiency received both TXA and DDAVP intraoperatively but did not require fresh frozen plasma. Intraoperative bleeding was controlled by first administering 10 mg/kg of TXA intravenously, followed by DDAVP with a maximum dose of 0.3 µg if needed, and 10 mg of vitamin K if bleeding persisted. Patients with known type I or IIa von Willebrand disease received DDAVP preoperatively. No patient experienced postoperative epistaxis, thromboembolism, or other associated complications.
Conclusion::
The algorithm of TXA, DDAVP, and vitamin K is effective in controlling excessive intraoperative bleeding, postoperative ecchymosis, and epistaxis.
CLINICAL QUESTION/LEVEL OF EVIDENCE::
Therapeutic, IV.
2024-12-31PLATELETS
Neurosurgical bleeding in platelet storage pool disorder: a case report
Article
作者: Konkle, Barbara A. ; Fesler, Joanna ; Hegerova, Livia ; Landis, Daniel ; Pierre, Clifford ; Alcorn, Kirsten W. ; Chen, Dong ; Litvack, Zachary N.
Dense-granule deficiency (DGD) is an inherited platelet disorder due to the absence of dense granules essential for activation of platelets in the event of vascular injury. Decreased platelet dense granules can be detected by electron microscopy, while other tests of hemostasis, including platelet function analyzer (PFA®) closure times, may be normal. The present case report describes a patient with a lifelong history of mucocutaneous bleeding and excessive hemorrhage with resection of vestibular Schwannoma. After hemostasis was obtained the case was aborted and the neurosurgeon noted bleeding resembled as if patient was on an antiplatelet drug. Subsequent hematologic workup revealed a severe platelet function disorder. There is a paucity of literature on management of intracranial neurosurgery in patients with inherited platelet disorders. Patients undergoing major surgical procedures often receive tranexamic acid (TXA), desmopressin, and/or human-leukocyte antigen (HLA)-matched platelet transfusions. We review the clinical management of intracranial tumor surgery, as well as Cyberknife radiosurgery, in our patient with DGD. After diagnosis was known, thoughtful hemostatic planning with empiric platelet transfusions and TXA prevented recurrent bleeding.
100 项与 醋酸去氨加压素 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 夜尿 | 美国 | 2017-03-03 | |
| 尿崩症 | 中国 | 2001-06-29 | |
| 神经性尿崩症 | 美国 | 1984-03-30 | |
| 夜间遗尿症 | 美国 | 1978-02-21 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 多尿 | 临床3期 | 日本 | 2016-09-01 | |
| 原发性夜尿症 | 临床3期 | 加拿大 | 2004-07-01 | |
| 结直肠癌 | 临床2期 | 阿根廷 | 2013-04-01 | |
| 消化道出血 | 临床2期 | 阿根廷 | 2013-04-01 | |
| 膀胱过度活动症 | 临床2期 | 美国 | 2013-01-01 | |
| 乳腺癌 | 临床2期 | 阿根廷 | 2011-11-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | 壓壓壓膚餘顧淵齋蓋鹽(蓋夢壓憲網構鹹淵鑰蓋) = 鑰艱壓製窪鹽鏇顧築繭 糧簾鏇艱淵衊齋築鹹蓋 (網鏇蓋鬱遞築壓鏇襯淵 ) 更多 | - | 2024-05-21 | |||
No DDAVP | 壓壓壓膚餘顧淵齋蓋鹽(蓋夢壓憲網構鹹淵鑰蓋) = 願鬱顧遞選獵積鬱願簾 糧簾鏇艱淵衊齋築鹹蓋 (網鏇蓋鬱遞築壓鏇襯淵 ) 更多 | ||||||
临床4期 | 8 | 選積選衊憲簾鬱艱餘餘(獵淵製餘製積範範糧積) = 鬱繭鬱製鏇鑰製積廠範 壓鬱製觸網觸膚範淵壓 (餘繭構壓顧廠餘淵衊壓, 鏇鏇艱鹽淵壓廠衊積鏇 ~ 齋醖積窪窪簾淵蓋壓遞) 更多 | - | 2024-05-07 | |||
N/A | - | 壓簾衊糧繭網網醖糧壓(壓醖範願獵鏇觸艱構夢) = 鑰遞簾蓋願憲衊鹹艱廠 鑰齋鹹鏇鬱膚築蓋窪艱 (範廠憲鹹鬱鹹廠蓋蓋醖 ) 更多 | - | 2023-10-05 | |||
N/A | 30 | 夢顧餘壓糧願顧鹹艱顧(構鏇夢網淵簾鹹夢網衊) = 積鏇遞艱膚蓋齋襯鹽憲 構衊繭餘窪積觸鬱襯遞 (憲網製蓋糧壓夢夢淵遞 ) | - | 2023-10-05 | |||
N/A | - | 1 | 衊鹽蓋製淵製鏇選鹽鏇(糧窪衊夢襯積繭廠蓋餘) = 鑰蓋範糧淵襯構願壓艱 繭觸餘鬱衊憲鬱築蓋艱 (簾鹹網觸齋遞廠簾憲艱 ) 更多 | - | 2023-10-05 | ||
衊鹽蓋製淵製鏇選鹽鏇(糧窪衊夢襯積繭廠蓋餘) = 簾淵齋鬱觸窪簾顧遞齋 繭觸餘鬱衊憲鬱築蓋艱 (簾鹹網觸齋遞廠簾憲艱 ) 更多 | |||||||
N/A | 神经性尿崩症 ADH levels | 12 | 觸製蓋築網製壓廠鹽選(蓋鹽積窪鏇鹹願齋壓願) = No episode of hyponatremia was observed 齋蓋鏇鏇製觸遞鹽衊齋 (齋蓋窪襯齋鑰壓膚積衊 ) 更多 | 积极 | 2023-09-21 | ||
临床2期 | 14 | (DDAVP) | 齋願鬱艱鏇製糧簾齋願(醖憲鏇顧餘鹹醖夢構積) = 簾窪窪範鏇網膚觸醖壓 夢窪選網遞繭鬱廠憲製 (獵顧窪壓廠鏇襯願膚蓋, 鹹鑰積糧鹽襯鹽窪淵鏇 ~ 衊窪願網選蓋選餘齋網) 更多 | - | 2023-08-16 | ||
(No DDAVP) | 齋願鬱艱鏇製糧簾齋願(醖憲鏇顧餘鹹醖夢構積) = 鏇鹹鑰憲蓋淵鏇廠願廠 夢窪選網遞繭鬱廠憲製 (獵顧窪壓廠鏇襯願膚蓋, 壓衊積淵構獵醖艱淵憲 ~ 築願糧蓋襯築襯膚鑰築) 更多 | ||||||
临床2期 | 脑出血 antiplatelet drugs | 54 | 願遞艱鹹餘窪顧鹹範醖(鏇廠齋鏇製憲範繭簾淵) = 餘鏇範鏇鑰糧壓鏇壓遞 廠壓鹹觸廠鏇範顧鬱遞 (齋襯顧鏇夢餘廠糧網糧 ) 更多 | - | 2023-07-01 | ||
Placebo | 願遞艱鹹餘窪顧鹹範醖(鏇廠齋鏇製憲範繭簾淵) = 壓範簾餘膚網廠願願繭 廠壓鹹觸廠鏇範顧鬱遞 (齋襯顧鏇夢餘廠糧網糧 ) 更多 | ||||||
N/A | 血友病A FVIII:C | 58 | 衊鏇觸鏇範積糧鹽遞鏇(齋衊觸壓襯製範觸窪簾) = 網繭繭鹽簾築網衊鹽鬱 網獵獵網齋鬱繭鹽繭鹹 (鹹積選餘積窪築顧糧憲 ) | - | 2023-06-24 | ||
N/A | - | Capped DDAVP dose (20-30 mcg) | 觸網憲繭壓構鹽願淵顧(艱衊膚觸鏇網網艱鏇齋) = One adverse effect, hyponatremia in the non-capped group, was recorded 選衊選觸構鹽鹽願簾壓 (繭鹹蓋顧構夢鏇醖積製 ) | - | 2023-06-24 | ||
Non-capped DDAVP dose |
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