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更新于：2026-05-08
Azelastine Hydrochloride
盐酸氮卓斯汀
更新于：2026-05-08
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C22H25Cl2N3O |
InChIKeyYEJAJYAHJQIWNU-UHFFFAOYSA-N |
CAS号79307-93-0 |
关联
37
项与 盐酸氮卓斯汀 相关的临床试验CTRI/2023/10/059139
A randomized controlled clinical trial to evaluate the efficacy of Anutaila Nasya and Azelastine Nasal Spray in management of Vataj Pratishyaya. - Nil
NCT06126952
Randomized, Double-blind, Cross-over Clinical Trial to Assess Onset of Action and Efficacy of Azelastine Hydrochloride 0.15% Nasal Spray in the Treatment of Allergen-Induced Allergic Rhinitis Symptoms in an Environmental Exposure Unit in Comparison to Placebo and Mometasone Furoate/Olopatadine Hydrochloride Nasal Spray
NCT05887843
An Open-label, Single-Dose, Three-way Crossover Study to Compare the Pharmacokinetics of Fixed-Dose Combination of Mometasone + Azelastine Nasal Spray to Mometasone and Azelastine Nasal Sprays in Adolescents (12 to 17 Years of Age) and Young Adults (18 to 24 Years of Age) With Seasonal Allergic Rhinitis
100 项与 盐酸氮卓斯汀 相关的临床结果
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100 项与 盐酸氮卓斯汀 相关的转化医学
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100 项与 盐酸氮卓斯汀 相关的专利（医药）
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768
项与 盐酸氮卓斯汀 相关的文献（医药）2026-03-01PEDIATRIC ALLERGY AND IMMUNOLOGY
Azelastine‐fluticasone intranasal therapy: A paradigm shift in pediatric allergic rhinitis management. A point of view of the Italian Society of Pediatric Allergy and Immunology
Review
作者: Tosca, Maria Angela ; Ciprandi, Giorgio ; Marseglia, Gianluigi ; Miraglia del Giudice, Michele ; Indolfi, Cristiana ; Licari, Amelia
Abstract:
Background:
Allergic rhinitis (AR) is one of the most prevalent chronic conditions in children and adolescents, significantly impacting quality of life and scholastic performance. Effective management requires therapeutic approaches that address the complex pathophysiology while ensuring safety and tolerability.
Methods:
This paper reviews the evidence supporting azelastine‐fluticasone combination intranasal therapy in pediatric allergic rhinitis, with a focus on efficacy, safety, and clinical implementation. This paper encompassed clinical trials, guidelines (ARIA), consensus statements (SIAIP Delphi Consensus), and real‐world evidence gathered from Italian primary care pediatricians managing children and adolescents with AR.
Results:
Azelastine‐fluticasone combination therapy demonstrates superior efficacy compared to monotherapy, exhibiting a rapid onset of action (15–30 min) and sustained symptom control. Its dual mechanism effectively addresses both early‐phase (H1‐receptor antagonism) and late‐phase (glucocorticoid anti‐inflammatory effects) allergic responses. Clinical trials conducted in adolescents aged 12–18 years confirm an excellent safety profile, with no significant effects observed on growth or the Hypothalamic–Pituitary–Adrenal (HPA) axis. Emerging evidence further may support its potential utility in younger children aged 6–12 years. The SIAIP Delphi Consensus on AR management, involving 42 pediatricians, achieved over 80% agreement on key management principles, particularly emphasizing the control of type 2 inflammation. Survey data collected from 864 Italian primary care pediatricians, collectively managing 81,231 children, indicates high adherence to ARIA guidelines (exceeding 70%) and a notable increase in the adoption of combination therapy, reaching up to 20% of cases.
Conclusion:
Azelastine‐fluticasone combination intranasal therapy represents a significant paradigm shift in pediatric allergic rhinitis management. It offers superior efficacy, an excellent safety profile, and practical advantages that foster better treatment adherence. This therapeutic approach is well‐aligned with contemporary guidelines and is increasingly being adopted in clinical practice for the management of moderate to severe AR in children and adolescents.
2025-12-01JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
Azelastine attenuates Cisplatin-induced renal and testicular injury: Involvement of Nrf2/SLC7A11-GPX4 and NCOA4-mediated ferroptosis
Article
作者: El Gayar, Amal M ; El-Ela, Salwa R Abo ; Zaghloul, Randa A
AIM:
Renal and testicular toxicities are side effects of the chemotherapeutic agent cisplatin (Cis). The study aims to assess the potential repurpose of Azelastine (Az), an H1-receptor antagonist to alleviate Cis-induced toxicity.
MATERIALS AND METHODS:
Sprague Dawley rats received Az (4 or 6 mg/kg/orally) for ten days and were challenged by a single i.p. injection of Cis (10 mg/kg) on the fifth day. Renal and testicular tissues were investigated using histopathology, immunohistochemistry, qRT-PCR, and ELISA techniques.
RESULTS:
Az (6 mg/kg) attenuated Cis-induced nephrotoxicity by reversing the elevation of serum creatinine, BUN, and urinary total protein [38.5 %, 32.3 % and 60 % (p < 0.0001)], and the decline of urinary creatinine and CrCl by 2.15- and 2.8-fold (p < 0.0001 and p < 0.01, respectively). Az (6 mg/kg) induced a significant decrease in both renal and testicular levels of MDA, tissue iron (70.9 %, 51 %, 44.5 % and 33.6 %, respectively, p < 0.0001) and TFR (27.6 %, p < 0.05 and 39 %, p < 0.0001, respectively). Moreover, Az up-regulated renal and testicular Nrf2 and GPX4 (6.9-, 15.6-, 3.9- and 4.8-fold, respectively, p < 0.0001). Both renal and testicular GSH and SLC7A11 were enhanced by Az (2.7-, 2.1-, 4.5-fold, p < 0.0001, and 3.4-fold, p < 0.01, respectively). Finally, Az induced a decrease of renal and testicular NCOA4 and FTH1 gene expressions (53.4 %, 48.6 %, 51.5 % and 41.3 %, respectively, p < 0.0001). Interestingly, Az enhanced the protein levels of NCOA4, but reduced FTH1 (44.5 %, p < 0.0001, 41 %, p < 0.001 and 1.29- and 1.33-fold p < 0.01, respectively) CONCLUSION: Az mitigates Cis-induced nephrotoxicity and testicular injury by inhibiting ferroptosis.
2025-11-01Journal of Family Medicine and Primary Care
Intermittent muffled hearing as a precursor to Bow Hunter’s syndrome: A diagnostic consideration for family physicians, ENT, and stroke specialists
Article
作者: Oddie-Okeke, Chiemelie ; Ahmed, Mohamed H. ; Alnawasrah, Allam
A
BSTRACTWe report the case of a 34-year-old female who presented with headaches, visual disturbances, and unsteadiness, mostly triggered by head rotation. She was otherwise healthy and taking the contraceptive pill (Yasmin) and fluticasone/azelastine nasal spray. Two months prior to admission, her general practitioner referred her to ear, nose, and throat (ENT) for intermittent muffled hearing in the left ear. ENT examination was unremarkable, and neurology referral was advised due to the episodic, self-resolving nature of symptoms. During admission, computed tomography (CT) head showed a low-density area in the left cerebral hemisphere. Magentic resonance imaging (MRI) revealed acute infarctions in the posterior circulation—specifically the cerebellum, occipital lobes, and posterior parietal lobes. A repeat MRI 48 h later showed a new right occipital infarct. MR angiogram and contrast MRI of the neck demonstrated smooth narrowing of the dominant left vertebral artery (V3 segment), consistent with dissection. Workup for secondary causes was normal. She was treated with dual antiplatelet therapy (aspirin and clopidogrel) for 3 months, followed by long-term clopidogrel and atorvastatin. The association between Bow Hunter’s Syndrome (BHS) and hearing symptoms is extremely rare, with fewer than five cases reported. This case suggests a potential link between intermittent muffled hearing and vertebrobasilar pathology. While causality is not definitively established, the findings warrant clinical consideration. Clinical implications for family physicians and ENT and stroke specialists can be: BHS in the differential diagnosis for episodic muffled hearing without ENT findings. Watch for associated symptoms (e.g., dizziness, neck pain, visual changes). Early referral for vascular imaging is essential to prevent cerebrovascular events.
100 项与 盐酸氮卓斯汀 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 呼吸道感染 | 美国 | 2021-06-17 | |
| 常年性变应性鼻炎 | 澳大利亚 | 2004-07-21 | |
| 变应性结膜炎 | 美国 | 2000-05-22 | |
| 季节性过敏性鼻炎 | 美国 | 1996-11-01 | |
| 血管舒缩性鼻炎 | 美国 | 1996-11-01 | |
| 皮炎 | 日本 | 1990-08-30 | |
| 湿疹 | 日本 | 1990-08-30 | |
| 痒疹 | 日本 | 1990-08-30 | |
| 瘙痒 | 日本 | 1990-08-30 | |
| 荨麻疹 | 日本 | 1990-08-30 | |
| 哮喘 | 日本 | 1986-04-30 | |
| 过敏性鼻炎 | 日本 | 1986-04-30 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 常年性鼻炎 | 临床3期 | 美国 | 2007-01-01 | |
| 慢性鼻炎 | 临床3期 | 美国 | 2006-07-01 | |
| 普通感冒 | 临床3期 | 美国 | 2006-07-01 |
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临床结果
临床结果
适应症
分期
评价
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N/A | 90 | 夢鏇艱選淵願顧廠獵選(願齋鹹顧壓繭壓遞網餘) = 餘顧夢獵積憲鬱艱範壓 範襯艱顧齋壓積簾觸構 (選衊蓋構獵遞鹹範鹹襯 ) 更多 | 积极 | 2024-09-07 | |||
Placebo | 夢鏇艱選淵願顧廠獵選(願齋鹹顧壓繭壓遞網餘) = 顧積觸築鬱衊觸餘選積 範襯艱顧齋壓積簾觸構 (選衊蓋構獵遞鹹範鹹襯 ) 更多 | ||||||
临床3期 | 110 | Azelastine HCl 0.15% nasal spray | 壓鏇窪鏇齋憲憲醖憲蓋(繭衊鑰選糧淵遞觸顧憲) = 遞鹹鹹鹹築醖壓網鬱壓 夢遞鬱廠餘鹹醖鬱廠廠 (願網憲觸窪鬱餘鹽鬱繭 ) | 积极 | 2024-07-01 | ||
N/A | 常年性变应性鼻炎 维持 | 87 | Fluticasone propionate/azelastine (FP/Aze 50/137 μg each nostril twice daily) | 憲選網遞淵鹽鹽齋糧蓋(鏇積糧積網鑰獵選製鹹): mean difference = 1.26 (95% CI, 0.59 ~ 1.93), P-Value = <0.001 | 积极 | 2024-02-23 | |
临床3期 | 581 | 鹹鬱構齋鏇願築顧繭蓋(廠簾選築糧簾蓋蓋餘積) = 鑰遞糧願鏇顧壓衊齋簾 鏇簾鏇範顧顧範襯簾鑰 (鏇糧範範鑰簾餘廠鏇衊, 3.99) | 积极 | 2023-10-18 | |||
鹹鬱構齋鏇願築顧繭蓋(廠簾選築糧簾蓋蓋餘積) = 顧鹹積鹽積製網簾艱窪 鏇簾鏇範顧顧範襯簾鑰 (鏇糧範範鑰簾餘廠鏇衊, 4.26) | |||||||
临床3期 | 900 | 鏇鹽夢淵壓糧餘蓋築衊(觸鏇齋鹽淵繭繭廠繭鏇): P-Value = 0.0007 更多 | - | 2023-09-01 | |||
Fluticasone propionate nasal spray | |||||||
Pubmed 人工标引  | 临床4期 | 111 | 餘襯遞醖壓製膚簾衊築(艱淵鹹齋淵獵鑰窪鬱網) = 獵顧衊顧顧構齋憲餘鏇 顧膚鬱築遞築鹽顧醖夢 (齋構鹹夢獵淵願艱齋衊, 2.19) 更多 | 积极 | 2022-07-04 | ||
餘襯遞醖壓製膚簾衊築(艱淵鹹齋淵獵鑰窪鬱網) = 簾憲壓製範淵膚簾網製 顧膚鬱築遞築鹽顧醖夢 (齋構鹹夢獵淵願艱齋衊, 8.46) 更多 | |||||||
临床3期 | 348 | 鹹衊構齋願獵艱構鹽鹹(鹽繭餘鬱選淵糧鹽壓壓) = 衊簾蓋選顧齋觸壓廠願 艱醖獵構淵鏇餘壓遞衊 (顧淵鑰齋範窪餘廠窪選, 5.154) 更多 | - | 2015-06-29 | |||
(Dymista Vehicle) | 鹹衊構齋願獵艱構鹽鹹(鹽繭餘鬱選淵糧鹽壓壓) = 鹹網遞網膚遞鹹選襯繭 艱醖獵構淵鏇餘壓遞衊 (顧淵鑰齋範窪餘廠窪選, 4.731) 更多 | ||||||
临床4期 | 191 | (Astepro 0.15% Nasal Spray) | 襯衊積餘願夢鏇醖夢築 = 襯齋衊淵鏇構範觸蓋網 網鑰製襯襯壓鏇衊鏇繭 (簾顧願製選窪醖範淵襯, 願餘顧鑰齋鏇廠範鑰餘 ~ 醖構鏇夢鬱壓繭憲糧蓋) 更多 | - | 2015-06-29 | ||
(Astepro 0.1% Nasal Spray) | 襯衊積餘願夢鏇醖夢築 = 憲襯顧獵鹹廠鏇選壓鏇 網鑰製襯襯壓鏇衊鏇繭 (簾顧願製選窪醖範淵襯, 顧選築範淵鏇鏇製壓淵 ~ 膚鑰築淵鹹積膚積鬱積) 更多 | ||||||
临床3期 | 489 | (MP03-36 (0.15% Solution)) | 齋窪憲齋鏇構憲襯膚構(遞觸鬱憲衊襯廠鹽鏇窪) = 衊壓鏇願網鑰鏇壓積鏇 鏇夢願膚鹽醖鹽願艱齋 (構糧築鬱觸願鑰鏇夢窪, 4.03) 更多 | - | 2012-06-11 | ||
(MP03-33 (0.10% Solution)) | 齋窪憲齋鏇構憲襯膚構(遞觸鬱憲衊襯廠鹽鏇窪) = 糧糧鹹廠繭獵餘製襯構 鏇夢願膚鹽醖鹽願艱齋 (構糧築鬱觸願鑰鏇夢窪, 4.37) 更多 | ||||||
临床4期 | 102 | 繭夢糧鑰鹽膚觸窪齋醖 = 淵構構壓獵壓獵鬱獵艱 網網積鬱壓網顧鹽膚繭 (獵獵餘廠襯簾襯餘憲願, 鑰願淵顧築蓋積蓋製願 ~ 淵廠製蓋鏇憲壓鹽襯膚) 更多 | - | 2010-02-02 |
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