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更新于：2026-05-07
Pioglitazone Hydrochloride
盐酸吡格列酮
更新于：2026-05-07
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 美国 (1999-07-15), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国)、孤儿药 (欧盟) |
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结构/序列
分子式C19H21ClN2O3S |
InChIKeyGHUUBYQTCDQWRA-UHFFFAOYSA-N |
CAS号112529-15-4 |
关联
579
项与 盐酸吡格列酮 相关的临床试验NCT07053319
Protocol lV: SGLT2 Inhibitors, Pioglitazone and Ketone Production in Type 2 Diabetes Mellitus
To examine whether the empagliflozin-induced stimulation of EGP, lipolysis, and ketone production in T2D individuals can be blocked by pioglitazone (which has direct hepatic and adipose tissue effects).
开始日期2026-07-20 |
NCT07056699
Protocol V: San Antonio Site Sub Study: Can Pioglitazone Block SGLT2 Inhibitor-induced Stimulation of Lipolysis, Ketone Production and Liver Glucose Production in Type I Diabetic Patients
Participants are being asked to be in a research study. Scientists do research to answer important questions which might help change or improve treatment of participants disease in the future.
In patients with Type 1 Diabetes (T1D), Dapagliflozin a Selective Glucose Transporter 2 Inhibitor (SGLT2i) is known to increase production of glucose in the liver, increase breakdown of fats (lipolysis), and increase production of ketones (ketogenesis). Ketones are chemicals produced by the liver when the body breaks down fat for energy instead of glucose. When the level of ketones in the body becomes too high, a condition called ketoacidosis develops. In this study, the study team will investigate whether adding pioglitazone (a medication commonly used to treat type 2 diabetes), can reduce the Dapagliflozin - induced liver glucose production, fat break down (lipolysis) and ketone body production (ketogenesis) in patients with Type 1 Diabetes (T1D).
In patients with Type 1 Diabetes (T1D), Dapagliflozin a Selective Glucose Transporter 2 Inhibitor (SGLT2i) is known to increase production of glucose in the liver, increase breakdown of fats (lipolysis), and increase production of ketones (ketogenesis). Ketones are chemicals produced by the liver when the body breaks down fat for energy instead of glucose. When the level of ketones in the body becomes too high, a condition called ketoacidosis develops. In this study, the study team will investigate whether adding pioglitazone (a medication commonly used to treat type 2 diabetes), can reduce the Dapagliflozin - induced liver glucose production, fat break down (lipolysis) and ketone body production (ketogenesis) in patients with Type 1 Diabetes (T1D).
开始日期2026-07-15 |
ChiCTR2600122952
Efficacy and Safety of Pioglitazone–Metformin and Ganagliflozin proline versus Metformin in Patients with Type 2 Diabetes Mellitus and MAFLD
开始日期2026-05-01 |
申办/合作机构 |
100 项与 盐酸吡格列酮 相关的临床结果
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100 项与 盐酸吡格列酮 相关的转化医学
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100 项与 盐酸吡格列酮 相关的专利（医药）
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5,586
项与 盐酸吡格列酮 相关的文献（医药）2026-08-01·BRAIN BEHAVIOR AND IMMUNITY
IL-4/IL-4Rα signaling activates PPARγ to promote oligodendrocyte differentiation and remyelination
Article
作者: Yu, Feng-Lin ; Yin, Yu-Jing ; Li, Si-Han ; Zou, Ya-Rou ; Zhang, Yuan ; Han, Bing ; Li, Huan ; Zhang, Lin-Jie ; Zhang, Yan ; Du, Ruo-Yan
The restoration of white matter damage is essential for the functional recovery observed in demyelinating diseases such as multiple sclerosis (MS). Interleukin 4 (IL-4), a type II cytokine, has been acknowledged for its protective role in modulating microglia and immune cells, thus suppressing inflammatory processes. Emerging evidence suggests that IL-4 extends beyond its immunomodulatory function, playing a part in memory, neuronal pruning, protection, and neurodegeneration. Here, our study identified the capacity of IL-4 to stimulate myelinogenesis and remyelination in the central nervous system. We observed dynamic changes in IL-4Rα expression during both developmental myelination and remyelination. Intranasal IL-4 administration during a critical postnatal period significantly enhanced myelination. Following demyelination induced by lysophosphatidylcholine, IL-4 was found to augment remyelination and restore motor function. Using genetic knockout experiments in vitro, we further showed that IL-4 binding to IL-4Rα and activating the PPARγ signaling pathway, thereby upregulating GPNMB, a downstream effector that promotes oligodendrocyte differentiation and myelination. These findings reveal a novel protective role for IL-4 in CNS repair, extending beyond its established functions in microglia, macrophages, or neurons. Intranasal IL-4 delivery may represent a promising therapeutic strategy for enhancing white matter integrity in leukodystrophies and MS. Abbreviations: MS, multiple sclerosis; IL-4, Interleukin 4; CNS, central nervous system; OPCs, oligodendrocytes precursor cells; IL-4R, IL-4 receptor; i.n., intranasal; LPC, lysophosphatidylcholine; PVL, periventricular leukomalacia; EAE, experimental autoimmune encephalomyelitis; dpi, days post immunization; dpl, days post lesion; Nkx2.2, NK2 homeobox 2; Olig2, oligodendrocyte transcription factor 2; OLs, oligodendrocytes; SOX10, SRY-Box Transcription Factor 10; PDGFRα, platelet derived growth factor receptor alpha; CNPase, 2',3'-Cyclic Nucleotide 3' Phosphodiesterase; APC, adenomatous polyposis coli; ASPA, aspartoacylase; GFAP, glial fibrillary acidic protein; Iba1, ionized calcium binding adaptor molecule 1; MBP, myelin basic protein; TEM, transmission electron microscopy; CC, corpus callosum; GCC, genu of the corpus callosum; CG, cingulum; CTX, cortex; STR, striatum; EC, external capsule; Pre-OLs, pre-myelinating oligodendrocytes; STAT6, signal transducer and activator of transcription 6; Pio, pioglitazone; T3, triiodothyronine; CNTF, ciliary neurotrophic factor; PPARγ, peroxisome proliferator-activated receptor γ.
2026-06-01·Cancer Epidemiology
Association between pioglitazone use and prostate cancer in patients with type 2 diabetes: A retrospective cohort study
Article
作者: Liao, Kuan-Fu ; Lai, Shih-Wei
OBJECTIVE:
Pioglitazone is commonly prescribed for glycemic control in type 2 diabetes mellitus (T2DM), yet its potential impact on prostate cancer risk remains uncertain. This study aimed to assess the association between pioglitazone use and incident prostate cancer among men with T2DM.
METHODS:
We conducted a retrospective cohort study using data from the TriNetX network. Men with T2DM aged 55-84 years were included. To form the pioglitazone and pioglitazone-naïve groups, men were matched 1:1 based on demographic and clinical characteristics. The primary outcome was the incidence of prostate cancer. Cumulative probability, hazard ratios, and 95% confidence intervals were calculated using the TriNetX "Compare Outcomes" module.
RESULTS:
After matching and applying a 3-month lag exclusion, 19,449 patients in the pioglitazone group and 19,455 patients in the pioglitazone-naïve group were included. During follow-up period, the proportions of men diagnosed with prostate cancer was about 0.566% in the pioglitazone group and 0.329% in the pioglitazone-naïve group. The hazard ratio for prostate cancer was 1.655 in the pioglitazone cohort compared to the pioglitazone-naïve cohort (95% confidence interval: 1.214-2.256).
CONCLUSION:
Pioglitazone use was associated with prostate cancer in men with T2DM aged 55-84 years, highlighting the need for careful risk assessment and further investigation.
2026-06-01·AGEING RESEARCH REVIEWS
Drug repurposing in Alzheimer's disease: Emerging therapeutic strategies and promising candidates
Review
作者: More, Pradip S ; Lohiya, Radheshyam T ; Lade, Swati N ; Umekar, Milind J ; Rangari, Shyam W ; Unidrwade, Diksha S ; Zanwar, Aarti S ; Burle, Sushil S
Alzheimer's disease is a progressive neurodegenerative disorder, and the most common cause of dementia, which causes 60-70 % of cases worldwide, and its prevalence is increasing by more than 55 million people globally, with an expected increase of 139 million cases by 2050. AD is characterized by Amyloid-β plaque deposition, tau hyperphosphorylation, synaptic dysfunction, neuroinflammation, and oxidative stress, which makes the pathophysiology multifactorial and complex in terms of the development of therapeutic treatment. Existing approved therapies, such as cholinesterase enzyme inhibitors and NMDA receptors antagonists, are merely symptomatic, whereas novel anti-amyloid monoclonal antibodies approved recently have low clinical efficacy with safety and cost issues. The low success rates of clinical trials highlight the necessity of alternative approaches. Drug repurposing of drugs has proved to be a promising solution, which uses drugs with know safety profiles to speed up the discovery of therapeutic solutions. These repurposed agents are used targeting diverse pathologic pathways, including amyloid aggregation, tau pathology, neuroinflammation, and synaptic dysfunction, with antidiabetic agents (metformin, GLP-1 receptor agonists) and anti-hypertensives (candesartan), anti-inflammatory ones (NSAIDs, pioglitazone), and neuroprotective ones (minocycline, sildenafil). Notably, mitochondrial dysfunction is becoming a significant early and essential cause of AD development, and mitochondria-targeted therapeutics like SS-31, Mdivi-1, MitoQ, DDQ, and SkQ1 are currently considered promising disease-modifying options. The development of artificial intelligence, multi-omics, and precision medicine also improves drug repurposing plans. Overall possibility to integrate multi-target repurposed therapies with novel technologies is a promising prospect to overcome the available shortcomings and improve clinical outcomes in AD.
379
项与 盐酸吡格列酮 相关的新闻（医药）2026-05-02
[图片]礼来（Eli Lilly and Company）介绍及公司主要历史变迁美国礼来公司（Eli Lilly and Company）是一家全球性的以研发为基础的医药公司，总部位于美国印地安那州印第安纳波利斯市，致力于为全人类提供以药物为基础的创新医疗保健方案。礼来公司于1876年5月10日，由Colonel Eli Lilly 创建，并最终以他的姓名命名。迄今已有近150年的历史。 公司的业务覆盖糖尿病、肿瘤、神经科学、心血管疾病等多个领域。 1923年，礼来推出了Iletin（动物来源的胰岛素），是世界上第一个动物胰岛素，用于当时尚无有效治疗手段的糖尿病。1928年，礼来推出了一种肝脏提取物产品，用于治疗恶性贫血，这是一种危及生命的血液疾病，几十年来一直是作为标准治疗方法。19世纪40年代，礼来发现了大量制备青霉素G的方法并实现青霉素G的大量生产。1955年，礼来在全球首次生产和销售索尔克脊髓灰质炎疫苗。1958年 强效抗生素万古霉素诞生，至今仍是严重院内感染患者的最后一道防线。1961年，礼来推出长春碱Velban (vinblastine），是从马达加斯加长春花植物的生物碱中提取的肿瘤药物，用来治疗多种癌症。1982年 ，礼来推出了Humulin（rDNA衍生的人胰岛素），为全球首个采用重组DNA技术的人胰岛素。1986年，礼来在比利时推出Prozac（盐酸氟西汀），用于治疗抑郁症。1996年，礼来推出Zyprexa（奥氮平）用于治疗精神分裂症。同年，推出Gemzar（盐酸吉西他滨），用于治疗胰腺癌和非小细胞肺癌。2004年，礼来推出Cymbalta（盐酸度洛西汀），用于治疗抑郁症。2007年1月29日，礼来收购了ICOS Corporation的全部股权，获得Cialis（他达拉非）的全部权利。2007年第2季度，收购了Hypnion, Inc. ，专注于睡眠障碍类产品研发的神经科学公司，同年收购了动物健康领域的制药公司Ivy Animal Health, Inc. 。2008年11月24日，礼来收购了ImClone Systems Inc. ，专注于癌症疗法研究。在收购前，已就Erbitux与ImClone达成多个合作协议。2008年10月1日，自Monsanto Company处收购了奶牛补充剂Posilac。2008年8月20日，收购了SGX Pharmaceuticals, Inc.，获得了其结构发现药物平台。2010年12月20日，收购了Avid全部股份，为一家主要专注于开发正电子发射（PET）扫描成像中的分子放射性药物示踪剂的公司。2010年7月20日，收购了Alnara，专注于开发代谢疾病的蛋白疗法。2010年5月28日，辉瑞收购Wyeth, Inc.时剥离了多个动物健康管线的欧洲市场权利，礼来对其进行了收购。2011年7月7日，礼来收购了Janssen的动物健康业务。2012年2月17日，礼来收购了ChemGen Corporation，专注于增强家禽、蛋、肉生产效率的饲料酶产品开发商业化的公司。 2015年1月1日，礼来收购了Novartis AH，诺华的兽用、宠物、农场和鱼类相关产品研发、生产和销售的子公司以及相关资产。2014年4月30日，礼来公司收购了德国私人控股的罗曼动物保健公司（Lohmann Animal Health），以加强其动物疫苗业务。 2017年1月3日，收购了Boehringer Ingelheim Vetmedica, Inc.的美国猫、犬和狂犬病疫苗组合以及包括用于治疗博德特拉氏菌、莱姆病、狂犬病和细小病毒等的疫苗，以及几个管线资产。2018年9月24日，礼来的动物健康业务Elanco完成IPO分拆上市。2019年2月15日，礼来公司以约80亿美元的现金收购已在纳斯达克上市的生物医药公司Loxo Oncology，这一举措旨在强化其肿瘤产品线，并收获Loxo Oncology公司管线中有一系列颇具市场潜力的药物。2019年10月，向亿腾医药出售希可劳（头孢克洛）和稳可信（万古霉素）在中国大陆市场的权利以及位于苏州的希可劳生产工厂。2020年1月10日，礼来宣布收购Dermira，获得其lebrikizumab等免疫管线。也获得了Qbrexza (glycopyrronium) 等产品。2021年1月，收购了Prevail，获得了其用于退行性疾病的AAV-9基因疗法管线。2022年12月，礼来收购了Akouos，获得了其听力损伤及其他内耳疾病的基因疗法管线。2023年7月，将奥氮平相关资产，包括Zeprexa出售给Cheplapharm Arzneimittel GmbH (Cheplapharm)。2023年6月，将Baqsimi出售给Amphastar Pharmaceuticals, Inc. 。2023年12月，完成收购POINT Biopharma Global Inc.，获得了其放射性药物发现、开发和生产平台。礼来2025年主要动态财务业绩方面：2025年礼来实现营业收入651.79亿美元，相比去年增长45%。主要得益于Zepbound和Mounjaro（替尔泊肽）的销售增长。礼来的总营业收入里，美国业务收入434.81亿美元，占全部业务收入的67%。[图片]礼来主要产品化合物专利预计到期时间如下表所示：[图片]国际审批方面：礼来于2025年官方网站披露的产品审批进度情况总结如下表，包括：Omvoh用于克罗恩病及溃疡性结肠炎、Jaypirca用于淋巴细胞白血病及小淋巴细胞淋巴瘤、Injuriyo用于乳腺癌、Kisunla用于阿尔茨海默症、Amyvid用于脑成像，评估淀粉样斑块密度，具体如下：[图片]合作授权方面：礼来在2025年披露的合作授权方面的交易包括与普渡大学扩展长期合作项目的合作。[图片]收并购方面：礼来在2025年披露的收并购交易包括：收购Scorpion Therapeutics, Inc.的PI3Kα抑制剂项目、收购SiteOne Therapeutics, Inc.，获得钠通道小分子抑制剂项目、收购Verve Therapeutics, Inc.获得靶向PCSK9基因编辑药物管线，收购Adverum Biotechnologies, Inc.获得玻璃体内基因治疗管线，具体如下：[图片]礼来总体营业收入情况礼来于2000年至2025年期间的主要收入包括人用药产品收入以及动物健康产品收入等。人用药产品收入包括药品销售收入以及合作授权收入等，动物健康产品收入主要为生产销售动物用药品疫苗等的收入。在2010年以来，礼来多次从其他大型国际药企收购其动物产品业务，以扩大其动物健康业务的销售收入。2015年，礼来的动物健康业务销售收入占了总营业收入的16%。在2018年，礼来完成了其动物健康业务的分拆上市。自此，礼来的动物健康部门从其业务中剥离出来独立运营。礼来自1876年成立以来至今，已有近150年历史。这期间有很多伟大的发明，包括胰岛素、青霉素G的批量生产、长春碱、度洛西汀、奥氮平、氟西汀等。2000年至2025年期间，2011年以前，由于创新药品的销售收入的逐年增加，礼来总营业收入稳步上升。2011年以来，由于市场竞争现有药品的销售收入迅速下降等因素，导致总营业收入下滑。直至2014年以后，新品的成功推出，收购扩展动物健康部门并实现成功剥离后，销售收入又回到了稳步上升阶段。2025年礼来实现总营业收入约651.79亿美元。[图片]礼来药品分类销售收入情况根据礼来每年披露的各药品销售收入情况，按照药品性质分类的销售收入数据如下图，礼来年报上没有披露的品种的销售收入统一归入其他类。2024年及以前礼来有披露数据的品种的销售收入之和占人用药品及其他收入的88%~96%，但2025年披露的品种数据骤然减少，披露的品种销售收入之和只占了总营业收入的82%。在整个研究期间，礼来药品销售收入2013年以前主要以神经类和糖尿病类为主，神经类是礼来的第一大品类，糖尿病、肿瘤和内分泌品类次之，生殖系统药物他达拉非在2002年推出以后，销售收入逐年增长，也贡献了很重要的部分。2013年以后，神经类药物由于市场竞争销售收入迅速下降，糖尿病品种由于度拉糖肽、恩格列净等新品的推出，销售收入逐年稳步上升成为礼来的第一大品类，近年来替尔泊肽的推出使得礼来糖尿病品类又一次实现销售收入的迅速跃升。2023年Zepound（替尔泊肽）减肥适应症的获批使得内分泌品类销售收入大幅增长。肿瘤类为礼来的第三大品类，免疫品类自2016年开始也逐年增长，成为礼来的第四大品类。[图片]礼来披露的各药品销售收入情况根据每年礼来年报披露的主要药品销售收入情况整理的单品变迁情况见下图。在研究期间前期，Zeprexa（奥氮平，再普乐）、Humulin（人胰岛素，优泌林）以及Fluoxetine（氟西汀，百优解）为主要品种。2004年推出Cymbalta（度洛西汀，欣百达）以及Alimta（培美曲塞，力比泰），2002年推出Cialis（他达拉非，希爱力），以及1996年就推出的Humalog（赖脯胰岛素，优泌乐）是研究期间中期主要发力的品种。研究阶段后半段，2014年推出的Trulicity（度拉糖肽，度易达）销售收入逐年迅速增长，直到2025年，2022年推出Mounjaro（替尔泊肽，穆峰达）、2024年新获批减肥适应症的Zepbound（替尔泊肽）、2017年推出的Verzenio（阿贝西利，唯择）、Trulicity，以及、Taltz（依奇珠单抗，拓咨）和2014年推出的Jardiance（恩格列净，欧唐静）是礼来的主要品种，这6个品种销售收入之和占礼来总营业收入的82.08%。[图片]礼来2025年药品销售收入情况根据2025年披露的各药品销售收入数据，将各药品分类，未披露销售收入数据的药品全部归入其他类。礼来2025年实现总营业收入651.79亿美元，包括糖尿病、内分泌、肿瘤、免疫以及其他品类。其中，糖尿病药物销售收入306.72亿美元，占总营业收入的47%。内分泌类药物（主要为Zepbound）实现销售收入135.42亿美元，占总营业收入的21%。抗肿瘤药物销售收入57.23亿美元，占总营业收入的9%。礼来2025年各品种销售收入如表。Mounjaro（替尔泊肽）为第一大品种，销售收入229.65亿美元，占总营业收入的35.23%。替尔泊肽的减肥适应症产品Zepbound销售收入135.42亿美元，占总营业收入的20.78%。总体来看，替尔泊肽中销售收入365.07亿美元，占总营业收入的56.01%。肿瘤类品种Verzenio为第三大品种，销售收入57.23亿美元，占总营业收入的8.78%。Trulicity为第四大品种，销售收入42.76亿美元，占总营业收入的6.56%。前六大品种中，除了Zepbound，Taltz和Verzenio，其余均为糖尿病品种。[图片][图片]披露的糖尿病类产品销售收入情况根据每年礼来披露的糖尿病类产品销售收入情况整理的各单品销售收入变迁情况见下图。[图片][图片]根据每年礼来披露的各品种销售收入情况整理，礼来于2000年至2025年的财报上披露有销售数据的糖尿病类药物有10个品种，2025年销售收入约为约306.72亿美元，占礼来总营业收入的47%。礼来糖尿病类品种包括：Mounjaro（替尔泊肽，穆峰达）、Trulicity（度拉糖肽，度易达）、Jardiance（恩格列净，欧糖静）、Humalog（赖脯胰岛素，优泌乐）、Humulin（人胰岛素，优泌林）、Basaglar（甘精胰岛素，优泌安）、Baqsimi（胰高血糖素）、Trajenta（利格列汀，欧唐宁）、Actos（吡格列酮，艾可拓）以及Byetta（艾塞那肽，百泌达）。礼来的胰岛素类产品包括Humulin（人胰岛素，优泌林）、Humalog（赖脯胰岛素，优泌乐）以及Basaglar（甘精胰岛素，优泌安），Humulin是礼来非常具有突破性的品种，全球首次采用重组DNA技术生产的人胰岛素，1982年获批，在本次的研究期间里，销售收入变动比较缓慢，2014年销售收入最高，约14.00亿美元。Humalog（赖脯胰岛素，优泌乐）是经过改进的短时胰岛素，1996年获批，2018年达峰值销售额约29.97亿美元。Basaglar（甘精胰岛素，优泌安）为赛诺菲的甘精胰岛素的生物类似物，为长效胰岛素，2014年获批，2020年峰值销售额约11.24亿美元。礼来的很多糖尿病品种是和勃林格殷格翰合作的，因此报表里的一些销售收入为联合销售中归属于礼来的销售收入，不能代表该品种的全球全部销售收入。礼来的较早推出的糖尿病老药包括：Actos（吡格列酮，艾可拓），1999年获批，为胰岛素增敏剂，激活PPAR-γ，调节糖脂代谢，研究期间销售收入约2~5亿美元。Byetta（艾塞那肽，百泌达），为肠促胰岛素分泌激素类似物，增强胰岛素分泌，2005年获批。Trajenta（利格列汀，欧唐宁）为二肽基肽酶（DPP-4）抑制剂，2011年获批，2019年峰值销售额约5.91亿美元。礼来近年来推出的品种包括：Trucility（度拉糖肽，度易达），为长效胰高血糖素样肽-1（GLP-1）受体激动剂，2014年获批，获批后销售收入迅速增长，2022年峰值销售额约74.40亿美元。Jardiance（恩格列净，欧唐静）为钠葡萄糖共转运体2（SGLT2）抑制剂，减少肾脏的葡萄糖重吸收，2014年获批，销售收入一直处于上升阶段，2025年销售收入约34.31亿美元。Baqsimi（胰高血糖素）为胰高血糖素鼻用粉雾剂，可迅速纠正低血糖，用于糖尿病患者的严重低血糖症状，2019年获批，2023年在礼来持有权利阶段销售收入约6.78亿美元，2023年6月将其出售给Amphastar Pharmaceuticals。Mounjaro（替尔泊肽，穆峰达）是最近推出的又一成功产品，为GIP受体和GLP-1受体激动剂，用于2型糖尿病的血糖控制，替尔泊肽在美国等地还以Zepbound的商品名获批用于减重，销量迅速增长。用于糖尿病适应症的Mounjaro于2022年获批，2023年销售收入迅速增至约51.63亿美元，2024年销售收入增至115.40亿美元，增长率超过了100%。2025年销售收入增至229.65亿美元，增长仍然超过了100%。综合来看，礼来的糖尿病品类主要包括老药、胰岛素产品以及近年推出的新药。老药的权利很多已被出售。胰岛素产品销售收入也进入下降阶段。在新药中，Trucility由于面临专利悬崖，销售收入进入了迅速下滑阶段，但Jardiance和Mounjaro的销售收入仍处于迅速增长阶段，且Mounjaro为礼来在市场上的爆款，销售收入迅猛增长，2024年和2025年销售收入增长率均超过了100%，未来还有很大的增长潜力，相信能够很好地抵销Trucility带来的销售收入下降冲击。在Mounjaro的带动下，糖尿病品类2025年销售收入实现了整体27%的增长。披露的肿瘤/免疫药品销售收入情况根据每年礼来披露的各品种销售收入情况整理的肿瘤/免疫类药物各单品销售收入变迁情况见下图。[图片][图片]根据每年礼来披露的各品种销售收入情况整理，礼来肿瘤类药物有6个品种，2025年销售收入约57.23亿美元，占礼来总营业收入的9%。免疫类品种3个，2025年销售收入约35.63亿美元，占2025年总营业收入的5%。礼来的肿瘤类品种包括：Verzenio（阿贝西利，唯择）、Cyramza（雷莫西尤单抗，希冉择）、Erbitux（西妥昔单抗，爱必妥）、Tyvyt（信迪利单抗，达伯舒）、Alimta（培美曲塞，力比泰）以及Gemzar（吉西他滨，健择）。注意，对于一些合作的品种，这里的收入仅为属于礼来的收入，而不是该品种的全部的全球销售收入。肿瘤品种里，较早的老药包括：Gemzar（吉西他滨，健择），主要通过其代谢产物抑制核苷酸还原酶的活性，用于非小细胞肺癌、胰腺癌、乳腺癌等，1996年获批，2008年达峰值销售额约17.20亿美元。Alimta（培美曲塞，力比泰），抑制胸苷酸合成酶、二氢叶酸还原酶及甘氨酰胺核苷酸甲酰转移酶等，用于非小细胞肺癌、恶性胸膜间皮瘤等，2004年获批，2014年达峰值销售额约27.92亿美元。Erbitux（西妥昔单抗，爱必妥）为靶向EGFR单抗，用于转移性结直肠癌，头颈癌等，2004年获批，研究期间里，2016年最高销售额约6.87亿美元。近年来推出的肿瘤品种包括：Cyramza（雷莫西尤单抗，希冉择），为VEGFR2拮抗剂，用于胃或胃食管结合部腺瘤，肝细胞癌等，2014年获批，2021年达峰值销售额约10.33亿美元。Verzenio（阿贝西利，唯择）为周期依赖性激酶4和6的抑制剂，用于乳腺癌，2017年获批，销售收入迅速增长，2025年销售额约57.23亿美元，销售收入处于迅速增长阶段。Tyvyt（信迪利单抗，达伯舒）为与中国信达合作的品种，为PD-1单抗，用于霍奇金淋巴瘤、非小细胞肺癌、肝细胞癌等，2018年获批，2024年礼来收入约5.26亿美元。综上可见，礼来肿瘤品类中，Cyramza销售收入由于专利临近到期等原因，销售收入在2024年又略微的下降，老品种销售收入下降区间也已接近尾声。新品种Verzenio销售收入近年来有迅速的增长，距离专利悬崖还有比较长的时间，未来还有很大的增长潜力。免疫类品种包括：Taltz（依奇珠单抗，拓咨）、Olumiant（巴瑞替尼，艾乐明）以及Xigris（drotrecogin α）。其中，最早推出的品种为Xigris，为重组人活化蛋白C，用于成年人严重败血症伴多器官衰竭，2002年欧盟获批，但很快就全球退市了，是一款不成功的品种。Taltz（依奇珠单抗，拓咨）为IL-17A单抗，用于中重度斑块型银屑病，2016年获批，上市后销售收入迅速增长，2025年销售收入约35.63亿美元。Olumiant（巴瑞替尼，艾乐明）为JAK1和2抑制剂，用于中重度活动性类风湿关节炎，2017年获批，2021年峰值销售额约11.15亿美元。综上可见，礼来的免疫品类中，Taltz和Olumiant均为2016年以后获批品种，距离专利悬崖还有一段时间，Taltz销售收入近年来也有迅速增长，Olumiant虽然近年销售收入有所反复。免疫品类未来也有一定的增长潜力。披露的神经/内分泌药品销售收入情况根据每年礼来披露的各品种销售收入情况整理的神经/内分泌类药物各单品销售收入变迁情况见下图。[图片][图片]根据每年礼来披露的各品种销售收入情况整理，礼来神经类药物包括7个品种，2025年未披露销售收入。内分泌类有4个品种，2025年有披露的销售收入约135.42亿美元，占全部营业收入的21%。礼来神经类品种包括：Emgality（加卡奈珠单抗，恩加乐）、 Zyprexa（奥氮平，再普乐）、 Cymbalta（度洛西汀，欣百达）、Strattera（托莫西汀，择思达）、Effient（普拉格雷）、Fluoxetine（Prozac/Sarafem，氟西汀，百优解）以及Symbyax（奥氮平/氟西汀）。神经类品种在研究期间的早期为礼来的主要品类，但后续由于市场竞争，销售收入迅速下降，2023年7月，礼来将奥氮平相关资产，包括Zeprexa出售给Cheplapharm Arzneimittel GmbH (Cheplapharm)。神经类品种有很多经典老药，包括：氟西汀，1987年获批，用于抑郁症、强迫症等；Zyprexa（奥氮平，再普乐），1996年获批，用于精神分裂症等，2010年峰值销售额达50.26亿美元；Strattera（托莫西汀，择思达）于2002年获批，用于注意缺陷多动障碍，2016年峰值销售额约8.55亿美元；Symbyax（奥氮平/氟西汀），2003年获批，用于双向情感障碍等；Cymbalta（度洛西汀，欣百达）于2004年获批，用于抑郁症焦虑症等，2013年峰值销售额达约50.84亿美元；Effient（普拉格雷）为血小板P2Y12抑制剂，用于动脉粥样硬化等，2009年获批，2016年峰值销售额约5.35亿美元；Emgality（加卡奈珠单抗，恩加乐）为2018年获批的新药，为CGRP抑制剂，用于偏头痛，2024年销售收入约8.70亿美元，销售收入仍在上升区间。综上可见，礼来的神经品类中，老药已由于销售收入进入下降末期或者对外出售基本退潮。内分泌类品种包括：Forteo/Forsteo（特立帕肽，复泰奥）、Zepbound（替尔泊肽）、Evista（雷洛昔芬，易维特）以及Humatrope（生长激素）。Humatrope（生长激素）为1986年获批的激素类产品，用于生长激素缺乏症，研究期间销售收入约3亿~5亿美元；Evista（雷洛昔芬，易维特）为1997年推出的老药，为选择性雌激素受体调节剂，用于绝经后妇女的骨质疏松症，2007年峰值销售额约10.91亿美元；Forteo/Forsteo（特立帕肽，复泰奥）为人内源甲状旁腺激素活性片段，也用于绝经后妇女的骨质疏松症，2002年获批，2017年峰值销售额约17.49亿美元。Zepbound（替尔泊肽）为2023年推出的减重药，替尔泊肽2022年曾以商品名Mounjaro获批用于2型糖尿病血糖控制。Zepbound为新适应症开发，Zepbound一上市就受到市场追捧，2024年就实现了销售收入约49.26亿美元，2025年实现销售收入135.42亿美元，相比2024年销售收入增长将近175%。总体来看，内分泌品类也是由于销售收入进入下降末期或者对外出售基本退潮，只有替尔泊肽的减重适应症药物Zepbound处于爆发式增长阶段，基于目前生活条件改善后，减重需求的爆发，相信Zepbound未来仍有很大的增长潜力。披露的其他药品销售收入情况根据每年礼来披露的各品种销售收入情况整理的其他类药物各单品销售收入变迁情况见下图。[图片][图片]根据每年礼来披露的各品种销售收入情况整理，礼来生殖系统类药物包括1个品种。抗病毒类品种1个。血液类品种1个。抗菌药类品种3个。添加剂类品种1个。消化系统类品种1个。礼来的生殖系统药物为Cialis（他达拉非，希爱力），为PDE5选择性抑制剂，用于男功能障碍。2002年获批，2016年峰值销售额约24.72亿美元。抗病毒类品种包括新冠类紧急用药（bamlanivimab/etesevimab），通过结合SARS-CoV-2刺突蛋白，阻止病毒侵入宿主细胞，主要在新冠期间紧急用于治疗轻中度新冠病毒感染，2021年销售额约22.39亿美元。目前并未获得正式批准。血液类品种为ReoPro（阿昔单抗），主要用于抗血栓形成，为GP IIb/IIIa拮抗剂，防止血小板聚集，1994年获批。研究期间销售收入约2亿~4.5亿美元。抗菌药类品种包括：Ceclor（头孢克洛，希刻劳）、Vancocin（万古霉素，稳可信）、Keflex（头孢氨苄）等品种，Keflex于1971年获批，Ceclor于1979年获批，Vanncocin于1986年获批。头孢氨苄和希刻劳均为头孢菌素类品种。万古霉素为糖肽类抗生素。Monensin（莫能菌素）为反刍动物饲料添加剂，控制瘤胃中挥发性脂肪酸比例，减少蛋白质降解，降低饲料干物质消耗，改善营养物质利用率，提高动物能量利用率。Axid（尼扎替丁）为消化系统药物，用于食道炎、十二指肠溃疡等，为强效H2受体拮抗药，阻断胃酸形成，1988年获批。综上，礼来的这些其他类药物，除新冠类药物为近年开发出来的以外，其余均为老药。已经淡出礼来主要药品之列。礼来2025年各单品销售收入增长情况礼来2025年各药品销售收入增长情况如表。礼来2025年总营业收入相比2024年增长了201.36亿美元（增长44.70%）。主要归因于替尔泊肽（Mounjaro，Zepbound）的销售增长，其中用于糖尿病适应症的Mounjaro2025年实现销售收入229.65亿美元，相比2024年增长114.25亿美元（增长率99.00%）。用于减重适应症的Zepbound2025年销售收入135.42亿美元，相比2024年增长86.16亿美元（增长率174.93%）。除替尔泊肽以外，Verzenio于2025年销售收入的增长也很显著。Verzenio增长了4.16亿美元（+7.85%），Taltz增长了3.03亿美元（+9.28%）。Trulicity于2025年销售收入的下降比较明显，Trulicity下降9.78亿美元（-18.61%），主要由于市场竞争的影响，以及临近专利悬崖。总体来看，礼来替尔泊肽等增长品种的潜力还很大，未来将还会保持增长态势，近期应该可以应对Trulicity等品种销售收入下降的冲击。礼来2025年披露销售收入的品种突然相比2024年有很大的减少因此，其余品种2025年销售收入的变动无法获知。[图片]总结礼来自1876年成立，至今有近150年的历史。曾推出重组人胰岛素、青霉素G、氟西汀、奥氮平、度洛西汀、万古霉素、长春碱等经典药物。在2000年至2025年的研究期间，前期礼来主要以神经类药物为主要品类，包括氟西汀（Prozac）、奥氮平（Zyprexa）、度洛西汀（Cymbalta）等主要产品。糖尿病、肿瘤和内分泌品类次之，糖尿病主要以Humulin（人胰岛素，优泌林） 、Humalog（赖脯胰岛素，优泌乐）为主。肿瘤产品主要为2004年推出的Alimta（培美曲塞，力比泰）。生殖系统药物Cialis（他达拉非，希爱力）在2002年推出以后，销售收入逐年增长，也贡献了很重要的部分。2013年以后，神经类药物由于市场竞争销售收入迅速下降，糖尿病品种由于Trulicity（度拉糖肽，度易达） 、 Jardiance（恩格列净，欧唐静）等新品的推出，销售收入逐年稳步上升成为礼来的第一大品类， 肿瘤类为礼来的第二大品类， 包括2017年推出的Verzenio（阿贝西利，唯择）等主要品种。免疫品类自2016年开始也逐年增长，包括Taltz（依奇珠单抗，拓咨）等主要品种，成为礼来的第三大品类。截至目前，礼来新推出的爆品替尔泊肽，为礼来2025年贡献了超过200亿美元的销售收入增长，替尔泊肽的糖尿病品种Mounjaro和减重品种Zepbound于2025年实现销售收入超过365亿美元，未来还有很大的增长潜力。礼来糖尿病品种是销售收入的主力，2025年糖尿病品种的销售收入占了总营业收入的47%。肿瘤类品种Verzenio（阿贝西利，唯择）和免疫类品种Taltz（依奇珠单抗，拓咨）上市后的销售收入增长也表现不俗。Trulicity（度拉糖肽）2025年的销售收入有了显著下降，主要由于市场竞争因素。Jardiance（恩格列净，欧唐静）销售收入略有一定的增长。可见，礼来目前的产品组合里，替尔泊肽继推出减重适应症后，糖尿病适应症和减重适应症均有了爆发式的销售收入增长，同时也有几个处于增长阶段的产品，未来仍有一段时间的增长预期。虽然Trulicity逐渐进入下行阶段，但近年来其他品种的增长应该可以很好地抵御其销售收入的下降。礼来主要药品全球销售收入数据整理（2000年至2025年）详见：礼来（EliLillyandCompany)主要药品全球销售收入数据整理（2000年至2025）本文的可编辑图表可在知识星球（阿司匹林投研）内下载，可关注公众号（乙酰水杨酸投研）加入知识星球
2026-05-01
·百度百家
体检报告上＂脂肪肝＂三个字，大概是当代成年人最熟悉的健康警报之一。全球超过30%的成年人受此影响，在中国，这个数字可能逼近3亿。我们习惯性地把它和＂喝酒＂＂肥胖＂画等号，觉得少吃两顿、多跑两步就能解决。但现实是，代谢相关脂肪性肝病（MAFLD）早已不是简单的＂ lifestyle issue ＂，它正悄无声息地成为肝硬化、肝癌的重要推手，而我们对其的认知和干预，很大程度上仍停留在经验主义的模糊地带。
从＂脂肪肝＂到MAFLD，改名不只是换标签
2020年，国际共识将沿用多年的＂非酒精性脂肪性肝病（NAFLD）＂正式更名为＂代谢相关脂肪性肝病（MAFLD）＂。
这一字之差，背后是诊断逻辑的彻底重构。过去，NAFLD是个＂排除性诊断＂——先排除酒精、病毒、药物等其他原因，剩下的才算。这种逻辑下，一个酗酒合并代谢紊乱的患者，反而可能被排除在外。MAFLD则反其道而行：代谢异常才是核心门槛，超重、胰岛素抵抗、血脂异常等成为诊断的必要条件。
改名的意义在于，它迫使临床和科研回归疾病的代谢本质。复旦大学附属中山医院的研究团队指出，这一转变将推动诊疗标准从＂模糊的经验判断＂转向＂明确的代谢表型识别＂，为后续精准干预奠定基础。
经验时代的三把＂钝刀＂，为何越来越力不从心
在MAFLD的临床管理中，我们长期依赖三把＂钝刀＂：生活方式干预、保肝药物、以及对高危人群的模糊筛查。
生活方式干预当然重要。减重7%-10%被证实能显著改善肝脏脂肪变和炎症。但问题是，＂管住嘴、迈开腿＂对相当一部分患者效果有限，尤其是已经出现纤维化的人群。更现实的是，临床中真正能做到并坚持科学减重的患者比例，低得令人沮丧。
药物治疗方面，维生素E、吡格列酮等虽有一定证据支持，但适用人群有限、副作用明确，远谈不上＂特效＂。全球范围内，至今没有一款药物被正式批准专门用于MAFLD的治疗。我们手里其实没有一张真正的＂王牌＂。
筛查同样困于经验。超声检查脂肪肝的灵敏度在脂肪变低于20%时显著下降，而肝穿刺活检虽然是金标准，却因其有创性无法大规模推广。FibroScan等无创手段正在普及，但基层医疗机构的配备率和操作规范性，仍是巨大的鸿沟。
我们现有的工具箱，对付一个影响数亿人的疾病，显得过于单薄了。
循证时代的曙光：从＂大概有用＂到＂精确打击＂
改变正在发生。MAFLD防治的循证化，体现在三个层面的突破。
第一，诊断的量化。 基于大数据的风险评分模型、多组学生物标志物、以及人工智能辅助的影像学分析，正在让＂早期识别＂变得更精准、更可及。2025年《Journal of Hepatology》发表的多中心研究显示，整合临床指标和组学数据的预测模型，对进展期纤维化的识别准确率已显著优于传统方法。
第二，治疗的靶向化。 针对MAFLD不同病理环节的药物研发进入爆发期。GLP-1受体激动剂在减重和改善肝脏组织学方面的双重获益，已获得多项临床试验证实；FGF21类似物、THR-β激动剂等新机制药物也在加速推进。这些药物的核心逻辑不再是＂广谱保肝＂，而是精准干预代谢紊乱和炎症纤维化的关键通路。
第三，管理的分层化。 基于纤维化风险和合并症谱的个体化随访方案，正在取代＂一刀切＂的复查建议。低风险人群可以延长随访间隔，将医疗资源集中在真正可能进展的高危患者身上——这是循证医学＂效率与公平＂原则的直接体现。
一个被低估的转折点：产业资本的用脚投票
循证时代的来临，从来不只是学术界的自我迭代，产业端的动向往往是更灵敏的晴雨表。
4月底，微滔生物完成超5000万美元的A轮及A+轮融资，由正心谷资本、德诚资本分别领投。这家从沙砾生物分拆出来的公司，核心管线GT801是一款体内CAR-T疗法，通过LNP递送mRNA技术，靶向CD19清除B细胞。其近期公布的临床前和早期临床数据，展现了在血液瘤和自身免疫疾病中的潜力。
为什么要提一家CAR-T公司？因为资本对创新疗法的密集布局，本质上是对＂经验医学＂天花板的一致判断——当传统手段触及瓶颈，基于分子机制的精准干预才是突破方向。MAFLD领域同样如此：从代谢手术到靶向药物，从无创诊断到数字疗法，资本正在用真金白银投票，押注循证医学的下一个十年。
普通人能做什么？答案比想象中具体
面对MAFLD，普通人最容易陷入两个极端：要么过度恐慌，要么彻底无视。
循证思维给出的答案是——建立个人化的风险档案。如果你超重、有糖尿病或血脂异常家族史、或者长期久坐，不妨在年度体检中主动要求肝脏弹性成像（FibroScan）和完整的代谢指标评估，而不是只做一张腹部超声。
如果已经确诊，不要急于尝试各种＂保肝偏方＂。目前唯一被充分证实有效的干预仍是科学减重，但＂科学＂二字有明确标准：在营养师指导下，以每周0.5-1公斤的速度稳步减重，配合抗阻训练和饮食结构调整。任何承诺＂快速逆转脂肪肝＂的方法，都值得警惕。
肝脏没有痛觉神经，它不会喊疼，但沉默从来不等于安全。 从经验到循证，MAFLD的防治范式正在经历一场迟到的革命。这场革命的最终受益者，不是实验室里的研究者，而是每一个在体检报告前犹豫着要不要正视那个＂轻度脂肪肝＂提示的普通人。
你最近一次认真看自己的肝功能报告，是什么时候？有没有哪个指标当时没在意，现在回想起来有点后怕？
2026-04-30
*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放
截至04月30日15点59分，近期共有 579 本期刊发布了 1148 篇文章，其中糖尿病相关的文章共 344 篇，覆盖 32 个领域的内容。中国专家参与发表的文章有 109 篇。今日，影响因子最高的文章刊登在 Journal of the American Medical Association (IF: 55.000) 期刊上。
今日头条
Headlines
01 Wound repair and regeneration IF: 03.400 糖尿病足溃疡住院后30天再入院：一项全国性分析
Sanaka, Krishna O, Mitra, Nandita, Margolis, David J, etc.
糖尿病足溃疡是糖尿病成人住院的常见原因，与高发病率和死亡率相关。住院后再入院仍然常见，但描述再入院模式和驱动因素的全国代表性证据有限。
这项回顾性队列研究使用了2022年美国全国再入院数据库，旨在描述30天全因再入院率，识别与再入院相关的因素，并比较美国糖尿病足溃疡住院成人的指标住院和再入院情况。通过诊断代码识别诊断为糖尿病足溃疡的成人住院，并进行调查加权分析以生成全国估计。
在估计的234,797次初始住院中，13.3%的患者在30天内再入院，超过了全国住院患者平均水平8.2%。再入院患者中肾脏疾病、心血管疾病和精神健康状况的患病率更高。多变量分析显示，肾脏疾病、心血管合并症、烟草使用、药物使用障碍和双相情感障碍与再入院风险增加相关。相反，初始住院期间的感染相关诊断和手术，包括骨感染、手术清创和下肢截肢，与再入院风险降低相关。再入院住院时间更长，急性全身性疾病患病率更高。
这些发现表明，糖尿病足溃疡住院后早期再入院主要由全身性医疗不稳定驱动，而非局部感染复发，强调了多学科住院和出院后护理策略的必要性。
本文由 韩玉莲 编辑
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Wound repair and regeneration | Volume 34, Issue 3
10.1111/wrr.70165
02 Journal of diabetes IF: 03.700 糖尿病神经病变的人口统计学和临床特征：来自2012-2017年韩国国民健康保险服务的数据
Jeong, Su Jin, Kim, Sun Keun, Kim, Chong Hwa, etc.
糖尿病神经病变（DN）是2型糖尿病（T2DM）最常见的慢性并发症，既往研究报告的患病率在23%至54.5%之间。本研究利用韩国国民健康保险服务（NHIS）2012年至2017年的数据，评估了DN的患病率、临床特征及治疗情况。
研究分析了NHIS样本数据中870万按年龄、性别、资格和收入分层的人群。DN的定义采用ICD-10编码（E10.4-E14.4, G59.0, G63.2, G99.0）以及同时开具糖尿病和DN处方的标准。计算了糖尿病患者中每年的DN患病率，并比较了有和无DN患者的治疗模式及患者特征。
结果显示，DN患病率从2012年的23.4%下降至2017年的21.5%。约半数DN患者接受了药物治疗，其中单药治疗比例高达82%，二联治疗占15%，三联治疗占3%。最常处方的药物是α-硫辛酸（52.1%-55.0%），其次是抗惊厥药（30.4%-34.5%）、三环类抗抑郁药、SNRIs和γ-亚麻酸。DN患者通常年龄较大，女性居多，且合并症更多，如高血压、血脂异常、心血管疾病、糖尿病足和截肢。他们更可能使用胰岛素或多种口服降糖药。
结论指出，约四分之一的T2DM患者患有DN，其中半数接受了治疗，主要为α-硫辛酸单药治疗。DN患者往往年龄较大且合并多种疾病，导致住院率更高。
本文由 天纳乾坤 编辑
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Journal of diabetes | Volume 18, Issue 5
10.1111/1753-0407.70196
03 JAMA dermatology IF: 11.000 美国国家银屑病基金会关于GLP-1受体激动剂治疗银屑病的入门指南：综述
Samip Sheth, Joseph F. Merola, Brittany N. Weber, Ronald Prussick, Jensen Yeung, Clive Liu, etc.
美国国家银屑病基金会医学委员会近日在《JAMA dermatology》上发表了一篇综述，为皮肤科医生介绍了GLP-1受体激动剂（GLP-1 RAs）在银屑病治疗中的应用。
银屑病是一种慢性免疫介导疾病，常伴有心血管、代谢、肌肉骨骼、精神、肝脏、肾脏和肺部共病。GLP-1 RAs已获美国食品药品监督管理局批准用于2型糖尿病、肥胖、心血管风险降低、慢性肾脏病、阻塞性睡眠呼吸暂停和代谢功能障碍相关脂肪性肝炎，这些疾病在银屑病患者中常见。新出现的证据表明，GLP-1 RAs和双重葡萄糖依赖性促胰岛素多肽/GLP-1激动剂可能通过免疫调节改善银屑病皮损。如果在大规模随机临床试验中得到证实，基于GLP-1的疗法可能为同时治疗皮肤疾病和心血管代谢共病提供机会。
综述的观察部分指出，GLP-1 RAs与银屑病面积和严重程度指数（PASI）评分降低相关，尤其在肥胖或2型糖尿病患者中。研究报告PASI相对降低约40%至80%，同时生活质量改善，但大多数研究规模较小（7-48例患者）、短期（≤6个月）且缺乏对照组。司美格鲁肽和利拉鲁肽与C反应蛋白、白细胞介素-6、血脂和内脏脂肪减少相关。在小型转化队列中，PASI改善与浅表脂肪和真皮γδ T细胞密度减少相关。GLP-1 RAs可与甲氨蝶呤、环孢素和生物制剂安全联用。不良反应主要为短暂胃肠道症状，胰腺炎和胆囊事件罕见。早期数据显示代谢和免疫调节双重益处。
综述结论认为，基于GLP-1的疗法靶向银屑病中共享的代谢和炎症通路。当前证据支持在选定的代谢共病患者中考虑辅助使用，但最终结论尚需更大规模随机临床试验证实。
本文由 韩玉莲 编辑
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JAMA dermatology | Ahead of Print.
10.1001/jamadermatol.2026.0859
04 Frontiers in endocrinology IF: 04.600 糖尿病视网膜病变与焦虑和抑郁的双向关系：一项荟萃分析
Fan, Seng, Gai, Ziyue, Ma, Hui, Wen, Ziye, Ma, Chunlei, Fan, Dongying, etc.
一项发表于《Frontiers in Endocrinology》的荟萃分析系统评估了糖尿病视网膜病变（DR）与焦虑、抑郁之间的双向关系。研究共纳入34项观察性研究，涉及383,195例患者，覆盖14个国家。
结果显示，DR患者发生抑郁的风险显著高于非DR患者（OR=1.58，95%CI:1.24-2.02，P<0.001）；反之，抑郁患者发生DR的风险也显著升高（OR=2.13，95%CI:1.53-2.98，P<0.001），提示两者存在双向关系。此外，DR患者发生焦虑的风险是非DR患者的2.23倍（95%CI:1.07-4.68，P=0.033）。
亚组分析表明，研究设计、地区和混杂因素可能是异质性的来源。敏感性分析显示结果总体稳健，但存在发表偏倚。
研究建议，在DR的临床治疗中应重视患者的心理状态，实施个性化心理护理，以改善患者预后。
本文由 韩玉莲 编辑
扫描二维码查看源文
Frontiers in endocrinology | Volume 17, Issue
10.3389/fendo.2026.1764745
中国发表（109）
China
Scientific reports IF: 03.900Ahead of Print.No.01A case control study of subjective sleep characteristics and polycystic ovary syndrome主观睡眠特征与多囊卵巢综合征的病例对照研究DOI: 10.1038/s41598-026-50477-3
Complement Ther Clin Pract IF: 03.000Ahead of Print.No.02Effect of acupoint catgut embedding therapy on polycystic ovary syndrome: a systematic review and meta-analysis穴位埋线疗法对多囊卵巢综合征有效性的系统评价与Meta分析DOI: 10.1016/j.ctcp.2026.102056
Journal of hazardous materials IF: 11.300Ahead of Print.No.03Biomarker-anchored screening of dietary microplastics via a gut microbiota-informed machine learning model基于肠道微生物组信息的机器学习模型实现膳食微塑料的生物标志物锚定筛查DOI: 10.1016/j.jhazmat.2026.142219
Chung-Hua Wai K'o Tsa ChihAhead of Print.No.04[Define benchmarks for low-risk sleeve gastrectomy: based on the greater China metabolic and bariatric surgery database]低风险袖状胃切除术的基准定义：基于大中华区减重代谢手术数据库DOI: 10.3760/cma.j.cn112139-20251110-00525
Orthopaedic surgery IF: 02.100Ahead of Print.No.05Research Progress on Risk Factors for Acute Kidney Injury After Antibiotic-Loaded Bone Cement Spacer Treatment for Periprosthetic Joint Infection抗生素骨水泥间隔物治疗假体周围感染后急性肾损伤危险因素的研究进展DOI: 10.1111/os.70327
Mol Cell Endocrinol IF: 03.600Ahead of Print.No.06Adiponectin ameliorates chronic-intermittent-hypoxia-induced insulin resistance by modulating macrophage inflammation in visceral white adipose tissue脂联素通过调节内脏白色脂肪组织巨噬细胞炎症改善慢性间歇性缺氧诱导的胰岛素抵抗DOI: 10.1016/j.mce.2026.112809
Biomaterials advances IF: 06.000Ahead of Print.No.07A upper critical solution temperature- and synergistic antioxidant-responsive tremella polysaccharide hydrogel for enhancing diabetic wound healing一种上临界溶解温度和协同抗氧化响应的银耳多糖水凝胶促进糖尿病伤口愈合DOI: 10.1016/j.bioadv.2026.214900
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.08Association Between Maternal Diabetes and the Risk of Cancers in Mother-Offspring: A Meta-Analysis of 44.9 Million Pregnancies母亲糖尿病与母子癌症风险的关联：一项基于4490万妊娠的荟萃分析DOI: 10.1111/dom.70835
Scientific data IF: 06.900Ahead of Print.No.09Chinese Food Images for Full-cycle Nutrition Analysis Towards Diabetes Management面向糖尿病管理的全周期营养分析的中餐图像数据集DOI: 10.1038/s41597-026-07334-9
Endocrine journal IF: 02.100Ahead of Print.No.10Soluble tumor necrosis factor receptors in diabetes: risk sensing and receptor-resolved targeting糖尿病中可溶性肿瘤坏死因子受体：风险感知与受体靶向策略DOI: 10.1507/endocrj.EJ26-0050
Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.11Letter to the editor-The predictive value of estimated glucose disposal rate for all-cause and cardiovascular mortality in the US non-diabetic population aged ≥60 years: A population-based cohort study致编辑的信——估计葡萄糖利用率对美国≥60岁非糖尿病人群全因和心血管死亡率的预测价值：一项基于人群的队列研究DOI: 10.1016/j.dsx.2026.103419
Talanta IF: 06.100Ahead of Print.No.12A novel time-gated luminescent ruthenium(II) complex probe for highly sensitive detection of methylglyoxal in foods and complex biological samples一种新型时间门控发光钌(II)配合物探针用于食品和复杂生物样品中甲基乙二醛的高灵敏检测DOI: 10.1016/j.talanta.2026.129907
Environmental research IF: 07.700Ahead of Print.No.13Long-term exposure to ambient PM(2.5) constituents and risk of microvascular complications among individuals with type 2 diabetes mellitus: a nationwide cohort study in UK长期暴露于环境PM2.5组分与2型糖尿病患者微血管并发症风险：一项英国全国性队列研究DOI: 10.1016/j.envres.2026.124589
Photodiagnosis Photodyn Ther IF: 02.600Ahead of Print.No.14Correlation between fundus color and retinal microcirculation in Type 2 Diabetes Mellitus patients2型糖尿病患者眼底颜色与视网膜微循环的相关性DOI: 10.1016/j.pdpdt.2026.105493
Ophthalmology IF: 09.500Ahead of Print.No.15Decoding Gene-Lifestyle Synergy in Diabetic Retinopathy Development: A Transethnic Prospective Cohort Study解码糖尿病视网膜病变发展中的基因-生活方式协同作用：一项跨种族前瞻性队列研究DOI: 10.1016/j.ophtha.2026.04.017
Biomedizinische Technik IF: 01.800Ahead of Print.No.16RetinalFRNet: retinal vessel segmentation in OCTA images using the feature reconstruction networkRetinalFRNet：利用特征重建网络在OCTA图像中进行视网膜血管分割DOI: 10.1515/bmt-2026-0107
Bioorganic chemistry IF: 04.700Ahead of Print.No.17Puerarin alleviates type 2 diabetes by targeting AKT1 to inhibit ferroptosis: Integrating network pharmacology, proteomics and experimental validation葛根素通过靶向AKT1抑制铁死亡缓解2型糖尿病：网络药理学、蛋白质组学与实验验证的整合研究DOI: 10.1016/j.bioorg.2026.109915
Immunopharmacol Immunotoxicol IF: 03.000Ahead of Print.No.18Vildagliptin alleviates cardiomyocyte apoptosis and inflammatory responses in the treatment of non-valvular atrial fibrillation by regulating the NO/sGC/cGMP signaling pathway维格列汀通过调节NO/sGC/cGMP信号通路减轻非瓣膜性心房颤动中的心肌细胞凋亡和炎症反应DOI: 10.1080/08923973.2026.2639559
Cell reports. Methods IF: 04.500Ahead of Print.No.19Integrated multi-dimensional modeling of non-model bacteria identifies engineering targets for acarbose biosynthesis optimization非模式细菌的多维整合建模鉴定阿卡波糖生物合成优化的工程靶点DOI: 10.1016/j.crmeth.2026.101426
Journal of ethnopharmacology IF: 05.400Ahead of Print.No.20Corrigendum to "Integrative pharmacology reveals the mechanisms of Erzhi Pill, a traditional Chinese formulation, against diabetic cardiomyopathy" [J. Ethnopharmacol., 296, (2022), 115474]对《整合药理学揭示传统中药方剂二至丸抗糖尿病心肌病的作用机制》[J. Ethnopharmacol., 296, (2022), 115474]的勘误DOI: 10.1016/j.jep.2026.121734
Cardiovascular Diabetology IF: 10.600Ahead of Print.No.21Metabolomic signatures of hepatic steatosis reveal heterogeneity in cardiometabolic risk and responses to lifestyle interventions in type 2 diabetes: a post hoc analysis肝脏脂肪变性的代谢组学特征揭示2型糖尿病中心血管代谢风险及生活方式干预反应的异质性：一项事后分析DOI: 10.1186/s12933-026-03194-0
ACS nano IF: 16.000Ahead of Print.No.22Self-Cascading Copper-Based Nanoassemblies Trigger Bacterial Cuproptosis-Like Death and Promote Wound Healing for Diabetic Drug-Resistant Bacterial Infections自级联铜基纳米组装体触发细菌铜死亡样死亡并促进糖尿病耐药细菌感染的伤口愈合DOI: 10.1021/acsnano.5c21619
Journal of medicinal chemistry IF: 06.800Ahead of Print.No.23Design and Synthesis of USP1 Inhibitors: Synergistic Antitumor Activity with PARP Inhibitors in Triple-Negative Breast CancerUSP1抑制剂的设计与合成：与PARP抑制剂在三阴性乳腺癌中的协同抗肿瘤活性DOI: 10.1021/acs.jmedchem.5c03804
ACS nano IF: 16.000Ahead of Print.No.24Clinically Validated Leptin Receptor as a Target for Liposomal Delivery of Metformin in Endometriosis Therapy临床验证的瘦素受体作为脂质体递送二甲双胍治疗子宫内膜异位症的靶点DOI: 10.1021/acsnano.5c18417
Gait & posture IF: 02.400Ahead of Print.No.25Multi-modal sensor fusion in smart footwear to capture altered gait dynamics in patients with diabetic peripheral neuropathy: System validation and clinical applications智能鞋具多模态传感器融合捕捉糖尿病周围神经病变患者步态动力学改变：系统验证与临床应用DOI: 10.1016/j.gaitpost.2026.110196
PloS one IF: 02.600Volume 21, Issue 4No.26Artemether ameliorates type 1 diabetic liver injury alongside the associated defects in mitochondrial ultrastructure and central carbon metabolism蒿甲醚改善1型糖尿病肝损伤及相关的线粒体超微结构和中心碳代谢缺陷DOI: 10.1371/journal.pone.0348214
Diabetes Metab Res Rev IF: 06.000Volume 42, Issue 4No.27Metformin: Historical Origins, Mechanisms of Action, and Emerging Clinical Applications二甲双胍：历史起源、作用机制及新兴临床应用DOI: 10.1002/dmrr.70171
Science progress IF: 02.900Volume 109, Issue 2No.28Leukocyte VCS parameters as potential auxiliary markers associated with diabetes and its inflammatory complications: A retrospective cross-sectional study白细胞VCS参数作为糖尿病及其炎症并发症潜在辅助标志物的回顾性横断面研究DOI: 10.1177/00368504261445505
Am J Chin Med IF: 05.500Ahead of Print.No.29Acupuncture for Neuropathic Pain: Mechanisms, Clinical Efficacy and Future Perspectives针灸治疗神经病理性疼痛：机制、临床有效性及未来展望DOI: 10.1142/S0192415X26500254
Future science OA IF: 02.100Volume 12, Issue 1No.30Mapping ophthalmic research on glycosylation and glycation: a PRISMA-compliant bibliometric and co‑citation analysis眼科糖基化与糖化研究图谱：一项符合PRISMA规范的文献计量与共引分析DOI: 10.1080/20565623.2026.2663167
International wound journal IF: 02.500Volume 21, Issue 2No.31Analysis of pathogen distribution and associated risk factors for surgical site infections following laparoscopic urological surgeries腹腔镜泌尿外科手术后手术部位感染的病原体分布及相关危险因素分析DOI: 10.1111/iwj.14721
Annals of hematology IF: 02.400Volume 105, Issue 5No.32Low dose of sitagliptin: effectively prevent liver aGVHD and accelerate neutrophil engraftment低剂量西格列汀：有效预防肝脏急性移植物抗宿主病并加速中性粒细胞植入DOI: 10.1007/s00277-026-07036-7
Minerva anestesiologica IF: 02.800Ahead of Print.No.33Efficacy of intranasal insulin in preventing postoperative delirium and its impact on insulin resistance in elderly non-cardiac surgical patients: a systematic review and meta-analysis鼻内胰岛素预防老年非心脏手术患者术后谵妄的有效性及其对胰岛素抵抗的影响：系统评价与荟萃分析DOI: 10.23736/S0375-9393.26.19719-3
Br J Hosp Med (Lond) IF: 01.800Volume 87, Issue 4No.34Clinical Efficacy of Continuous Nursing Plus Shared Outpatient Care on Remission of Type 2 Diabetes Mellitus延续性护理联合共享门诊管理对2型糖尿病缓解的临床有效性DOI: 10.31083/BJHM49861
Clin Pharmacol Drug Dev IF: 01.800Volume 15, Issue 5No.35Comparative Pharmacokinetics and Bioequivalence Assessment of Metformin/Pioglitazone Tablet in Fasting and Fed Conditions: A Randomized Study in Healthy Chinese Subjects二甲双胍/吡格列酮片在空腹和进食条件下的比较药代动力学和生物等效性评估：一项在中国健康受试者中开展的随机研究DOI: 10.1002/cpdd.70063
Br J Hosp Med (Lond) IF: 01.800Volume 87, Issue 4No.36Clinical Value of High-Channel 12-Lead Holter in Assisting Early Identification of Arrhythmias in High-Risk Populations高通道12导联动态心电图在高危人群心律失常早期识别中的临床价值DOI: 10.31083/BJHM52968
JAHA IF: 05.300Ahead of Print.No.37Allostatic Load of Glucose Homeostasis, Epigenetic Biomarkers, and All-Cause and Cardiovascular Death: A Prospective Cohort Study葡萄糖稳态的适应性负荷、表观遗传生物标志物与全因及心血管死亡：一项前瞻性队列研究DOI: 10.1161/JAHA.125.047287
Kaohsiung J Med Sci IF: 03.100Ahead of Print.No.38ZFP36L1 Enhances Microglial Ferroptosis in Ischemic Stroke by Reducing FTO-Mediated N6-Methyladenosine Demethylation of ACSL1 mRNAZFP36L1通过减少FTO介导的ACSL1 mRNA N6-甲基腺苷去甲基化增强缺血性卒中中的小胶质细胞铁死亡DOI: 10.1002/kjm2.70212
International wound journal IF: 02.500Volume 21, Issue 2No.39RETRACTED: The effect of placing drains and no drains after caesarean section in obese patients on patients' post-operative wound complications: A meta-analysis已撤回：肥胖患者剖宫产后放置引流管与不放置引流管对术后伤口并发症影响的荟萃分析DOI: 10.1111/iwj.14576
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.40Gut microbiome dysbiosis in PCOS: from pathogenesis to microbiome-targeted therapies多囊卵巢综合征中的肠道微生物群失调：从发病机制到微生物靶向治疗DOI: 10.3389/fendo.2026.1747766
BMC public health IF: 03.600Ahead of Print.No.41Associations between multiple air pollutants and insulin resistance in Chinese adults: the moderating role of physical activity多种空气污染物与中国成年人胰岛素抵抗的关联：体力活动的调节作用DOI: 10.1186/s12889-026-27595-8
Reprod Biol Endocrinol IF: 04.700Volume 24, Issue 1No.42Editorial expression of concern: Resveratrol relieves gestational diabetes mellitus in mice through activating AMPK编辑关注声明：白藜芦醇通过激活AMPK缓解小鼠妊娠期糖尿病DOI: 10.1186/s12958-026-01560-x
Fayixue zazhiVolume 42, Issue 1No.43[Synthetic Drug： Pregabalin]合成药物：普瑞巴林DOI: 10.12116/j.issn.1004-5619.2026.360302
BMC ophthalmology IF: 01.700Volume 26, Issue 1No.44Correlation between the expression levels of miR-199a-3p and FN1 in serum and aqueous humor and the severity of type 2 diabetic retinopathy in a Chinese population中国人群中血清和房水中miR-199a-3p与FN1表达水平与2型糖尿病视网膜病变严重程度的相关性DOI: 10.1186/s12886-026-04838-1
BMC endocrine disorders IF: 03.300Ahead of Print.No.45The role of resistance training in improving beta-cell function in type 2 diabetes: a systematic review and meta-analysis抗阻训练改善2型糖尿病β细胞功能的作用：系统综述与荟萃分析DOI: 10.1186/s12902-026-02286-y
Journal of nanobiotechnology IF: 12.600Ahead of Print.No.46Extracellular vesicles inherit lactate from aggregated MSCs to alleviate type 1 diabetes mellitus via H(2)S-induced CD8(+) T cell exhaustion细胞外囊泡继承聚集间充质干细胞的乳酸通过H2S诱导CD8+ T细胞耗竭缓解1型糖尿病DOI: 10.1186/s12951-026-04466-3
Frontiers in psychiatry IF: 03.200Volume 17, Issue No.47The associations of systemic inflammation and insulin resistance-related indicators with psychopathology and BDNF in patients with chronic schizophrenia慢性精神分裂症患者全身炎症和胰岛素抵抗相关指标与精神病理学及BDNF的关联DOI: 10.3389/fpsyt.2026.1802167
Frontiers in neurology IF: 02.800Volume 17, Issue No.48Beyond BMI: independent and opposing effects of overweight and obesity and triglycerides on 90-day functional outcomes after acute ischemic stroke超越体重指数：超重与肥胖和甘油三酯对急性缺血性卒中后90天功能结局的独立且相反的影响DOI: 10.3389/fneur.2026.1782157
Frontiers in immunology IF: 05.900Volume 17, Issue No.49Targeted regulation of adipose tissue macrophages from an immunometabolic perspective: a novel therapeutic approach for obesity-related metabolic disorders从免疫代谢角度靶向调控脂肪组织巨噬细胞：肥胖相关代谢性疾病的新治疗策略DOI: 10.3389/fimmu.2026.1803488
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.50Association between stress hyperglycemic ratio and stroke in older people with metabolic syndrome: a prospective cohort study from UK Biobank应激性高血糖比率与代谢综合征老年人群卒中风险的关联：一项来自英国生物样本库的前瞻性队列研究DOI: 10.3389/fendo.2026.1758847
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.51Endocrine-informed monitoring of scoliosis in Prader-Willi syndrome: integrating neuroendocrine pathophysiology, growth hormone therapy, and pubertal transitionPrader-Willi综合征脊柱侧弯的内分泌指导监测：整合神经内分泌病理生理学、生长激素治疗与青春期过渡DOI: 10.3389/fendo.2026.1803919
FCVM IF: 02.900Volume 13, Issue No.52Efficacy and safety of levosimendan in acute heart failure patients with different body mass index: a multicenter, retrospective, observational real-world study左西孟旦在不同体重指数急性心力衰竭患者中的有效性和安全性：一项多中心、回顾性、观察性真实世界研究DOI: 10.3389/fcvm.2026.1790085
Frontiers in nutrition IF: 05.100Volume 13, Issue No.53The correlation between nutrition index scores and nutrition status of preschool children in a district of Shanghai上海市某区学龄前儿童营养指数评分与营养状况的相关性研究DOI: 10.3389/fnut.2026.1746871
Frontiers in nutrition IF: 05.100Volume 13, Issue No.54Associations of umbilical cord vitamin D levels with childhood cardiometabolic risks: a longitudinal mother-child study脐带维生素D水平与儿童期心脏代谢风险的关联：一项纵向母婴研究DOI: 10.3389/fnut.2026.1777909
Frontiers in nutrition IF: 05.100Volume 13, Issue No.55Fasting blood glucose to high-density lipoprotein cholesterol ratio and MASLD risk: non-linear association and BMI mediation in non-diabetic adults空腹血糖与高密度脂蛋白胆固醇比值与非糖尿病成人脂肪性肝病风险的非线性关联及体重指数的中介作用DOI: 10.3389/fnut.2026.1818931
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.56Predictive Value of the second-Trimester Triglyceride-Glucose Index and Its Derived Indices for Macrosomia in Gestational Diabetes Mellitus妊娠期糖尿病孕妇孕中期甘油三酯-葡萄糖指数及其衍生指数对巨大儿的预测价值DOI: 10.2147/DMSO.S577687
J Int Med Res IF: 01.500Volume 54, Issue 4No.57A metabolic-inflammatory phenotype of pelvic floor dysfunction: A machine learning-based cross-sectional study in a nationally representative US population盆底功能障碍的代谢炎症表型：一项基于机器学习、具有全国代表性的美国人群横断面研究DOI: 10.1177/03000605261438949
J Int Med Res IF: 01.500Volume 54, Issue 4No.58Association between anthropometric indices and mortality risk among individuals with depression: A population-based cohort study抑郁患者人体测量指标与死亡风险的关联：一项基于人群的队列研究DOI: 10.1177/03000605261442794
Am J Respir Cell Mol Biol IF: 05.300Ahead of Print.No.59FTO Alleviates COPD Pathogenesis by Demethylating S100A9 to Suppress ERK1/2-Drp1-Driven MitophagyFTO通过去甲基化S100A9抑制ERK1/2-Drp1驱动的线粒体自噬减轻COPD发病机制DOI: 10.1093/ajrcmb/aanag094
Diabetology & metabolic syndrome IF: 03.900Volume 18, Issue 1No.60Beyond the known: prospective research directions for the gut-brain axis in obesity and type 1 diabetes mellitus超越已知：肥胖与1型糖尿病中肠脑轴的未来研究方向DOI: 10.1186/s13098-025-02038-3
BMC women's health IF: 02.700Ahead of Print.No.61PCOS combined with obesity aggravates the metabolic and immune abnormality in females多囊卵巢综合征合并肥胖加重女性代谢与免疫异常DOI: 10.1186/s12905-026-04492-1
International wound journal IF: 02.500Volume 21, Issue 2No.62Evaluation of diabetic foot care knowledge, determinants of self-care practices and the efficacy of health education糖尿病足护理知识、自我护理实践的决定因素及健康教育的有效性评估DOI: 10.1111/iwj.14704
International wound journal IF: 02.500Volume 21, Issue 2No.63RETRACTED: Efficacy of autologous platelet-rich plasma combined with negative pressure sealing drainage in the treatment of patients with diabetic foot ulcer自体富血小板血浆联合负压封闭引流治疗糖尿病足溃疡患者的有效性：一项系统评价与荟萃分析DOI: 10.1111/iwj.14700
International wound journal IF: 02.500Volume 21, Issue 2No.64RETRACTED: Effects of continuing nursing intervention on high-risk patients with diabetic foot ulcers: A meta-analysis持续护理干预对高危糖尿病足溃疡患者有效性的荟萃分析DOI: 10.1111/iwj.14683
Frontiers in bioscience IF: 03.100Volume 31, Issue 4No.65Emodin Alleviates Lipid Accumulation and Renal Tubular Injury in Rats With DN via Inhibiting HIF-1α Expression大黄素通过抑制HIF-1α表达减轻糖尿病肾病大鼠脂质蓄积和肾小管损伤DOI: 10.31083/FBL49862
Frontiers in bioscience IF: 03.100Volume 31, Issue 4No.66Effect of Endogenous FGF21 Deficiency on the Inflammatory Microenvironment of the Retina内源性FGF21缺乏对视网膜炎症微环境的影响DOI: 10.31083/FBL47702
J Integr Neurosci IF: 02.700Volume 25, Issue 4No.67Regional Associations Between Ocular Vascular Parameters and Enlarged Perivascular Spaces in the Basal Ganglia and Centrum Semiovale眼部血管参数与基底节和半卵圆中心血管周围间隙扩大的区域关联DOI: 10.31083/JIN49070
J Diabetes Investig IF: 03.000Ahead of Print.No.68Comment on 'Glycemic control and renal function decline in patients with chronic coronary syndrome: A multicenter cohort study'对《慢性冠状动脉综合征患者的血糖控制与肾功能下降：一项多中心队列研究》的评论DOI: 10.1111/jdi.70325
Materials horizons IF: 10.700Ahead of Print.No.69Multi-kingdom biofilms breached: microneedle delivery of metabolically targeted organic silver-photosensitizers for polymicrobial infections in diabetic foot ulcers多界生物膜突破：微针递送代谢靶向有机银光敏剂治疗糖尿病足溃疡中的多种微生物感染DOI: 10.1039/d6mh00459h
J Diabetes Investig IF: 03.000Ahead of Print.No.70Letter to the Editor in response to the article 'Prevalence and risk factors of sarcopenia in Asian adults with type 2 diabetes: A systematic review and meta-analysis'对《亚洲2型糖尿病成人肌少症的患病率与危险因素：系统综述与荟萃分析》一文的致编辑信DOI: 10.1111/jdi.70323
Frontiers in surgery IF: 01.800Volume 13, Issue No.71Risk factors associated with postoperative necrosis after digital replantation: a systematic review and meta-analysis断指再植术后坏死相关危险因素的系统评价与Meta分析DOI: 10.3389/fsurg.2026.1795247
Frontiers in neurology IF: 02.800Volume 17, Issue No.72Incidence of cognitive impairment post first stroke: a systematic review and meta-analysis首次卒中后认知障碍发生率的系统评价与荟萃分析DOI: 10.3389/fneur.2026.1782749
Frontiers in physiology IF: 03.400Volume 17, Issue No.73Efficacy and safety of gabapentinoid combination therapy versus monotherapy for the treatment of neuropathic pain加巴喷丁类药物联合治疗与单药治疗神经病理性疼痛的有效性和安全性比较DOI: 10.3389/fphys.2026.1802999
Frontiers in medicine IF: 03.000Volume 13, Issue No.74Incidence and risk factors of oral mucosal pressure injury in patients with oral tracheal intubation: systematic review and meta-analysis经口气管插管患者口腔黏膜压力性损伤发生率及危险因素的系统评价与Meta分析DOI: 10.3389/fmed.2026.1783726
Frontiers in medicine IF: 03.000Volume 13, Issue No.75Association between serum 25-hydroxyvitamin D, nutritional status, and inflammatory markers in sepsis patients with and without sarcopenia脓毒症合并与不合并肌少症患者血清25-羟基维生素D、营养状态和炎症标志物的关联研究DOI: 10.3389/fmed.2026.1816016
Frontiers in medicine IF: 03.000Volume 13, Issue No.76Construction and validation of a machine learning-based prediction model for postoperative complications in patients with chronic otitis media基于机器学习的慢性中耳炎术后并发症预测模型的构建与验证DOI: 10.3389/fmed.2026.1805224
Frontiers in medicine IF: 03.000Volume 13, Issue No.77Impact of liuwei dihuang pills (decoction) on early diabetic nephropathy: a systematic review and meta-analysis六味地黄丸（汤）对早期糖尿病肾病影响的系统评价与Meta分析DOI: 10.3389/fmed.2026.1802975
Maternal-fetal medicine IF: 01.700Volume 8, Issue 2No.78Global Guidelines on Placenta Accreta Spectrum Disorders: A Commentary From the Chinese Perspective全球胎盘植入性疾病指南：来自中国视角的评论DOI: 10.1097/FM9.0000000000000320
Frontiers in immunology IF: 05.900Volume 17, Issue No.79Influences of dietary intake on Chinese women with gestational diabetes mellitus by inhibiting gut microbiome on plasma metabolome膳食摄入通过抑制肠道微生物组对血浆代谢组的影响在中国妊娠期糖尿病女性中的作用DOI: 10.3389/fimmu.2026.1745459
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.80Association of the glucose metabolism continuum (fasting plasma glucose/HbA1c) with tear-film stability and secretion: ocular surface evidence across non-diabetes, prediabetes, and diabetes血糖代谢连续谱（空腹血糖/糖化血红蛋白）与泪膜稳定性和分泌的关联：跨越非糖尿病、糖尿病前期和糖尿病的眼表证据DOI: 10.3389/fendo.2026.1788051
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.81Machine learning-based prediction of NAFLD in patients with type 2 diabetes using routine clinical and biochemical indicators基于常规临床和生化指标的机器学习预测2型糖尿病患者非酒精性脂肪性肝病DOI: 10.3389/fendo.2026.1761846
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.82New findings in diabetic kidney disease: correlation and enhanced combined diagnostic value of sclerostin and 25(OH)VD糖尿病肾脏病新发现：硬骨素与25(OH)VD的相关性及联合诊断价值提升DOI: 10.3389/fendo.2026.1817017
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.83The association of serum uric acid with severity and prognosis of patients with diabetic foot ulcers血清尿酸与糖尿病足溃疡患者严重程度及预后的关联DOI: 10.3389/fendo.2026.1732361
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.84Low early-pregnancy serum lipoprotein(a) as an independent associated factor for gestational diabetes mellitus: a retrospective cohort study孕早期血清脂蛋白(a)低水平是妊娠期糖尿病的独立相关因素：一项回顾性队列研究DOI: 10.3389/fendo.2026.1780579
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.85Correction: Multi-feature integrated machine learning prediction model for early nephropathy in elderly living with type 2 diabetes mellitus更正：多特征集成机器学习预测模型用于老年2型糖尿病患者早期肾病DOI: 10.3389/fendo.2026.1807912
Int Med Case Rep J IF: 00.600Volume 19, Issue No.86Ultrasound-Guided Superior Laryngeal Nerve Block Combined with Cricothyroid Membrane Puncture for Awake Tracheal Intubation in a Patient with a Laryngeal Tumor: A Case Report and Literature Review超声引导喉上神经阻滞联合环甲膜穿刺用于喉肿瘤患者清醒气管插管：病例报告与文献综述DOI: 10.2147/IMCRJ.S589800
Frontiers in nutrition IF: 05.100Volume 13, Issue No.87Association between cumulative changes of the C-reactive protein-triglyceride glucose index and the incidence of rapid kidney function decline: a nationwide prospective cohort studyC反应蛋白-甘油三酯葡萄糖指数累积变化与肾功能快速下降发生率的关联：一项全国性前瞻性队列研究DOI: 10.3389/fnut.2026.1795444
Frontiers in nutrition IF: 05.100Volume 13, Issue No.88Structural elucidation and antidiabetic activity of polysaccharides from the parasitic plant Orobanche cumana寄生植物向日葵列当多糖的结构解析与抗糖尿病活性研究DOI: 10.3389/fnut.2026.1785297
Frontiers in nutrition IF: 05.100Volume 13, Issue No.89Microbiota-metabolites interaction associated with glycemic improvement following a dietary herbal intervention in type 2 diabetes2型糖尿病膳食草药干预后与血糖改善相关的微生物群-代谢物相互作用DOI: 10.3389/fnut.2026.1793130
Frontiers in nutrition IF: 05.100Volume 13, Issue No.90New directions in mulberry leaf research for diabetes: a translational approach based on multi-component synergy桑叶糖尿病研究新方向：基于多组分协同的转化策略DOI: 10.3389/fnut.2026.1792767
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.91FGFR1/YAP1 signaling in endothelial cells drives renal fibrosis and offers a therapeutic target内皮细胞中FGFR1/YAP1信号驱动肾脏纤维化并提供治疗靶点DOI: 10.3389/fphar.2026.1766265
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.92Paeoniflorin as a candidate disease-modifying therapy for diabetic peripheral neuropathy: mechanisms, exposure challenges, and translational priorities芍药苷作为糖尿病周围神经病变候选疾病修饰疗法：机制、暴露挑战与转化优先事项DOI: 10.3389/fphar.2026.1751578
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.93Development and Validation of a Nursing-Integrated Nomogram to Predict 1-Year Ulcer Recurrence in Patients with Diabetic Foot Ulcers After Endovascular Therapy整合护理评估的列线图预测糖尿病足溃疡患者血管内治疗后1年溃疡复发的开发与验证DOI: 10.2147/DMSO.S591186
The FASEB journal : IF: 04.200Volume 40, Issue 9No.94The E3 Ligase RNF8 Promotes Ubiquitination and Degradation of ChREBPα During Liver Stress ResponseE3连接酶RNF8在肝脏应激反应中促进ChREBPα的泛素化和降解DOI: 10.1096/fj.202600106R
Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 3No.95Hypoglycaemia Risk Prediction Models for Type 2 Diabetes: A Systematic Review and Meta-Analysis2型糖尿病低血糖风险预测模型的系统评价与荟萃分析DOI: 10.1002/edm2.70227
Journal of diabetes IF: 03.700Volume 18, Issue 5No.96Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes胰腺β细胞功能中的线粒体稳态：糖尿病的机制与治疗靶点DOI: 10.1111/1753-0407.70228
Chinese Medical Journal IF: 07.300Ahead of Print.No.97Molecular mechanisms and novel therapeutic targets of diabetic kidney disease糖尿病肾病的分子机制与新型治疗靶点DOI: 10.1097/CM9.0000000000004025
J Int Med Res IF: 01.500Volume 54, Issue 4No.98Emerging therapies for type 1 diabetes: Immunotherapy and gene editing advances1型糖尿病新兴疗法：免疫治疗与基因编辑进展DOI: 10.1177/03000605261440833
J Int Med Res IF: 01.500Volume 54, Issue 4No.99Endothelial activation and stress index links to cardiovascular disease in postmenopausal women mediated by arterial stiffness: A cross-sectional study of National Health and Nutrition Examination Survey 1999-2018内皮激活与应激指数与绝经后女性心血管疾病相关：动脉僵硬度的中介作用——基于1999-2018年美国国家健康与营养调查的横断面研究DOI: 10.1177/03000605261434398
J Int Med Res IF: 01.500Volume 54, Issue 4No.100Effects of probiotic supplementation on glycemic control in children with type 1 diabetes: A systematic review and meta-analysis益生菌补充对1型糖尿病儿童血糖控制的影响：系统评价与荟萃分析DOI: 10.1177/03000605261443077
Frontiers in nutrition IF: 05.100Volume 13, Issue No.101Plant-based caloric restriction diets versus conventional calorie-restricted diets for weight loss and metabolic health in obese adults: a 12-week randomized, open-label, non-inferiority trial植物性热量限制饮食与传统热量限制饮食对肥胖成人减重和代谢健康的影响：一项12周随机、开放标签、非劣效性试验DOI: 10.3389/fnut.2026.1805225
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.102Bidirectional relationship of diabetic retinopathy with anxiety and depression: a meta-analysis糖尿病视网膜病变与焦虑和抑郁的双向关系：一项荟萃分析DOI: 10.3389/fendo.2026.1764745
J Integr Neurosci IF: 02.700Volume 25, Issue 4No.103Roles of Metformin and Pioglitazone in Regulating A1-like Astrocyte Activation in EAE Mice二甲双胍和吡格列酮在调节EAE小鼠A1样星形胶质细胞激活中的作用DOI: 10.31083/JIN47364
Frontiers in microbiology IF: 04.500Volume 17, Issue No.104Metformin exacerbates diabetic amyotrophy via oxidative stress and gut microbiota alterations达格列净通过氧化应激和肠道菌群改变加重糖尿病性肌萎缩DOI: 10.3389/fmicb.2026.1778515
Frontiers in immunology IF: 05.900Volume 17, Issue No.105Sheep placental extract ameliorates polycystic ovary syndrome in rats by regulating ERβ-mediated Treg cells via the TGF-β1/Smad3 signaling pathway羊胎盘提取物通过TGF-β1/Smad3信号通路调节ERβ介导的Treg细胞改善大鼠多囊卵巢综合征DOI: 10.3389/fimmu.2026.1777841
Journal of nanobiotechnology IF: 12.600Ahead of Print.No.106Bio-inspired suction cup microneedle loaded fusion membrane targeting nano-drug delivery system treat androgenetic alopecia仿生吸盘微针负载融合膜靶向纳米递药系统治疗雄激素性脱发DOI: 10.1186/s12951-026-04391-5
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.107Quercetin in metabolic diseases: mechanisms, therapeutics, and multidimensional frontiers槲皮素在代谢性疾病中的作用：机制、治疗和多维前沿DOI: 10.3389/fendo.2026.1800322
Frontiers in public health IF: 03.400Volume 14, Issue No.108Dissociation between subjective sleep quality and lipid dysregulation in underground miners: night shift work as an independent risk factor for hypercholesterolemia井下矿工主观睡眠质量与血脂异常的解离：夜班工作是高胆固醇血症的独立危险因素DOI: 10.3389/fpubh.2026.1759787
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.109The DBC1-HIF-1α-PPAR-γ axis regulates Treg cell differentiation to promote myocardial fibrosis in experimental diabetic cardiomyopathy through the paracrine secretion of AregDBC1-HIF-1α-PPAR-γ轴通过旁分泌Areg调节Treg细胞分化促进实验性糖尿病心肌病心肌纤维化DOI: 10.3389/fendo.2026.1780666
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Atención primaria IF: 01.600Ahead of Print.No.59[Effectiveness of telemedicine interventions for the management of gestational diabetes in primary care centers]远程医疗干预在基层医疗中心管理妊娠期糖尿病中的有效性DOI: 10.1016/j.aprim.2026.103504
Diabetes & metabolism IF: 04.700Ahead of Print.No.60Bone phenotype in familial partial lipodystrophy type 2: insulin resistance and sclerostin家族性部分脂肪营养不良2型中的骨表型：胰岛素抵抗与硬骨素DOI: 10.1016/j.diabet.2026.101762
Eye IF: 03.200Ahead of Print.No.61Risk of cerebrovascular and cardiovascular outcomes in patients with an ICD code for ocular migraine眼型偏头痛患者脑血管和心血管结局的风险DOI: 10.1038/s41433-026-04479-0
Scientific reports IF: 03.900Ahead of Print.No.62Reimbursement restrictions reduce liver fibrosis screening in adults with diabetes in Ontario: a population-based interrupted time series analysis报销限制降低了安大略省糖尿病成人患者的肝纤维化筛查率：一项基于人群的间断时间序列分析DOI: 10.1038/s41598-026-48600-5
J Diabetes Complications IF: 03.100Ahead of Print.No.63Association between chronic low-grade inflammation and metabolic syndrome and their impact on the risk of coronary artery disease in type 1 diabetes1型糖尿病中慢性低度炎症与代谢综合征的关联及其对冠状动脉疾病风险的影响DOI: 10.1016/j.jdiacomp.2026.109331
BMJ open IF: 02.300Volume 16, Issue 4No.64Prevent 6:1 trial: pI rotocol for a feasibility trial of a 6:1 intermittent diet for weight gain prevention in women at increased risk of breast cancerPrevent 6:1试验：6:1间歇性饮食预防乳腺癌高风险女性体重增加的可行性试验方案DOI: 10.1136/bmjopen-2025-113204
Trends Endocrinol Metab IF: 12.600Ahead of Print.No.65Neuroprotective strategies for cognitive decline in type 2 diabetes2型糖尿病认知衰退的神经保护策略DOI: 10.1016/j.tem.2026.04.003
Endocrinol Diabetes Metab Case Rep IF: 00.700Volume 2026, Issue 2No.66Pheochromocytoma and primary hyperparathyroidism: a very rare association in a neurofibromatosis type 1 patient unmasked by Takotsubo syndrome嗜铬细胞瘤与原发性甲状旁腺功能亢进症：Takotsubo综合征揭示的1型神经纤维瘤病患者中极为罕见的关联DOI: 10.1530/EDM-25-0109
Internal medicine IF: 01.100Ahead of Print.No.67Impact of Tirzepatide on FIB-4 in Patients with Type 2 Diabetes: A Comparison between GLP-1RA-naïve and GLP-1RA Switch Initiation in a Retrospective Cohort替尔泊肽对2型糖尿病患者FIB-4的影响：GLP-1RA初治与转换治疗的回顾性队列比较DOI: 10.2169/internalmedicine.6886-25
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.68Efficacy and Safety of Pregabalin and Alpha-Lipoic Acid Combination in Patients With Painful Diabetic Peripheral Neuropathy: A Randomized, Open-Label, Non-Inferiority, Phase IV Clinical Trial and Subgroup Analysis (OPTIMUM Study)普瑞巴林与α-硫辛酸联合治疗痛性糖尿病周围神经病变患者的有效性和安全性：一项随机、开放标签、非劣效性、IV期临床试验及亚组分析（OPTIMUM研究）DOI: 10.1111/dom.70795
Domestic animal endocrinology IF: 02.100Ahead of Print.No.69Ertugliflozin decreases the insulin spike in non-insulin dysregulated standardbred horses following intra-articular triamcinolone administration艾托格列净降低非胰岛素调节异常的标准马关节内注射曲安奈德后的胰岛素峰值DOI: 10.1016/j.domaniend.2026.107016
Annals of family medicine IF: 05.100Ahead of Print.No.70Underuse of Pharmacologic Therapies for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Before Specialist Evaluation专科评估前肌痛性脑脊髓炎/慢性疲劳综合征药物治疗使用不足DOI: 10.1370/afm.250266
Nature IF: 48.500Ahead of Print.No.71A cell atlas charts the immune architecture of diabetic kidney disease细胞图谱揭示糖尿病肾病的免疫结构DOI: 10.1038/d41586-026-01177-5
Cardiovascular Diabetology IF: 10.600Ahead of Print.No.72Cardiovascular–kidney–metabolic syndrome: a comprehensive review of pathophysiology, epidemiology, diagnosis, and management心血管-肾脏-代谢综合征：病理生理学、流行病学、诊断和管理的全面综述DOI: 10.1186/s12933-026-03177-1
JMIR serious games IF: 04.100Volume 14, Issue No.73User Experience of a Virtual Reality-Based Treadmill for Children With a Chronic Disease Affecting Physical Health: Cross-Sectional Feasibility Study基于虚拟现实的跑步机对患有影响身体健康的慢性疾病儿童的用户体验：横断面可行性研究DOI: 10.2196/82953
Hormone research in p?diatrics : IF: 02.700Ahead of Print.No.74U.S. Adolescents of Asian Ethnicity have Higher Risk of Polycystic Ovary Syndrome美国亚裔青少年患多囊卵巢综合征风险更高DOI: 10.1159/000552156
Journal of obesity IF: 03.900Volume 2026, Issue 1No.75Prevalence and Factors Associated With Severe Obesity Among U.S. Adults: A Cross-Sectional Study美国成年人重度肥胖的患病率及相关因素：一项横断面研究DOI: 10.1155/jobe/3831008
JMIR human factors IF: 03.000Volume 13, Issue No.76Continuous Glucose Monitoring for Personalized Nutrition in Real-World Vively App Users: Retrospective Observational Study真实世界Vively应用用户中持续葡萄糖监测用于个性化营养的回顾性观察研究DOI: 10.2196/80734
JMIR human factors IF: 03.000Volume 13, Issue No.77Evaluation of Combined Educational Methods on Motivational Interviewing for Final-Year Medical Students: Mixed Methods Study联合教育方法对医学生动机性访谈能力的影响：混合方法研究DOI: 10.2196/89126
Annals of Cardiac Anaesthesia IF: 01.300Ahead of Print.No.78Incidence and Associated Factors of ST-Segment Changes in Noncardiac Surgery Under General Anesthesia全身麻醉下非心脏手术ST段改变的发生率及关联因素DOI: 10.4103/aca.aca_243_25
Zh Nevrol Psikhiatr Im S S KorsakovaVolume 126, Issue 4. Vyp. 2No.79[Transitional cognitive syndrome: Reconsidered classification of cognitive disorders]过渡性认知综合征：认知障碍分类的再思考DOI: 10.17116/jnevro202612604247
PloS one IF: 02.600Volume 21, Issue 4No.80Catastrophic health care expenditure among older people with non-communicable diseases in 11 European Union Member States11个欧盟成员国患有非传染性疾病的老年人灾难性医疗支出研究DOI: 10.1371/journal.pone.0346341
Einstein IF: 01.100Volume 24, Issue No.81Factors associated with sleep quality and duration in mothers of children with autism spectrum disorder: a cross-sectional study自闭症谱系障碍儿童母亲睡眠质量与时长相关因素：一项横断面研究DOI: 10.31744/einstein_journal/2026AO2004
Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.82SGLT2 Inhibitors versus GLP-1 Receptor Agonists Type 2 Diabetes, The Kidney ConundrumSGLT2抑制剂与GLP-1受体激动剂在2型糖尿病中的比较：肾脏难题DOI: 10.2215/CJN.0000001068
Zh Nevrol Psikhiatr Im S S KorsakovaVolume 126, Issue 4. Vyp. 2No.83[Current evidence-based approaches to the treatment of vascular cognitive impairment]当前血管性认知障碍治疗的循证方法DOI: 10.17116/jnevro202612604278
PloS one IF: 02.600Volume 21, Issue 4No.84Spatial and temporal modeling of breast cancer mortality in Kansas: An R-INLA approach堪萨斯州乳腺癌死亡率时空建模：基于R-INLA方法DOI: 10.1371/journal.pone.0347607
PloS one IF: 02.600Volume 21, Issue 4No.85Implications of acute change in estimated Glomerular Filtration Rate (eGFR) for the effect of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) on long-term endpoints估算肾小球滤过率急性变化对钠-葡萄糖协同转运蛋白2抑制剂长期终点效应的影响DOI: 10.1371/journal.pone.0347741
AIDS IF: 03.100Volume 40, Issue 6No.86SGLT2 inhibitor dapagliflozin attenuates HIV-associated cardiac fibrosis, steatosis and diastolic dysfunction in a mouse model via inhibition of TGFβ signalingSGLT2抑制剂达格列净通过抑制TGFβ信号减轻HIV相关的心脏纤维化、脂肪变性和舒张功能障碍（小鼠模型）DOI: 10.1097/QAD.0000000000004464
The Lancet HIV IF: 13.000Volume 13, Issue 5, Page e287-e356No.87Incidence, risk factors, and cardiovascular impact of hypertension in people with HIV: a secondary analysis of the REPRIEVE trialHIV感染者高血压的发病率、危险因素及心血管影响：REPRIEVE试验的二次分析DOI: 10.1016/S2352-3018(26)00036-6
PloS one IF: 02.600Volume 21, Issue 4No.88Criterion validity and divergent risk profiles of long-term opioid therapy across medicare and medicaid长期阿片类药物治疗在Medicare和Medicaid中的标准效度及风险特征差异DOI: 10.1371/journal.pone.0347943
JMIR research protocols IF: 01.500Volume 15, Issue No.89The Current Landscape of Remote Patient Monitoring Regarding Diabetes Mellitus and Hypoglycemia: Protocol for a Scoping Review远程患者监测在糖尿病和低血糖管理中的现状：范围综述方案DOI: 10.2196/88197
Science advances IF: 12.500Volume 12, Issue 18No.90IRS4 is a PI3K-activating cancer dependency up-regulated through DNA rearrangements or epigenetic mechanisms in multiple solid tumorsIRS4是一种通过DNA重排或表观遗传机制在多种实体瘤中上调的PI3K激活型癌症依赖性基因DOI: 10.1126/sciadv.aeb3503
Annals of Cardiac Anaesthesia IF: 01.300Ahead of Print.No.91Incidence and Predictors of Postoperative Atrial Fibrillation Following Cardiac Surgery: A Systematic Review心脏手术后新发房颤的发生率及预测因素：一项系统综述DOI: 10.4103/aca.aca_285_25
Heart Rhythm IF: 05.700Ahead of Print.No.92Identification of Clinical Risk Factors for Arrhythmia Recurrence in Atrial Fibrillation Patients Undergoing Catheter Ablation: A Systematic review and Meta-analysis房颤导管消融术后心律失常复发的临床危险因素识别：系统评价与荟萃分析DOI: 10.1016/j.hrthm.2026.04.046
Heart IF: 04.400Ahead of Print.No.93Derivation and validation of a prediction model for long-term mortality in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention: the PREDICT-ST-Elevation Myocardial Infarction scoreST段抬高型心肌梗死患者经皮冠状动脉介入治疗后长期死亡率预测模型的推导与验证：PREDICT-STEMI评分DOI: 10.1136/heartjnl-2026-327811
Indian Journal of Ophthalmology IF: 01.800Volume 74, Issue 5No.94Biosimilar anti-vascular endothelial growth factor agents: Clinical outcomes, safety, and cost-effectiveness in India生物类似药抗血管内皮生长因子制剂在印度的临床结局、安全性和成本有效性DOI: 10.4103/IJO.IJO_3222_25
JAMA dermatology IF: 11.000Ahead of Print.No.95Deuterated Pentoxifylline Analog in the Treatment of Necrobiosis Lipoidica: A Nonrandomized Clinical Trial氘代己酮可可碱类似物治疗类脂质渐进性坏死：一项非随机临床试验DOI: 10.1001/jamadermatol.2026.0863
Lasers in medical science IF: 02.400Volume 41, Issue 1No.96Photobiomodulation combined with dynamic thermal imaging as a diagnostic tool for chronic leg ulcers光生物调节联合动态热成像作为慢性腿部溃疡的诊断工具DOI: 10.1007/s10103-026-04878-5
Am J Physiol Heart Circ Physiol IF: 04.100Ahead of Print.No.97Myeloid transglutaminase 2 regulates Treg-Th17 balance in a female model of Angiotensin II-induced hypertension and vascular stiffening髓系转谷氨酰胺酶2在血管紧张素II诱导的高血压和血管硬化雌性模型中调节Treg-Th17平衡DOI: 10.1152/ajpheart.00095.2026
Journal of fluorescence IF: 03.100Ahead of Print.No.98Design and Optimization of a Glucose Fluorescence Nano-biosensor Based on Graft Copolymer of Poly(acrylic acid)-co-(vinyl phenyl boronic acid)-g-gelatin to Modify CdTe/TGA QDs基于聚丙烯酸-co-乙烯基苯硼酸-g-明胶接枝共聚物修饰CdTe/TGA量子点的葡萄糖荧光纳米生物传感器的设计与优化DOI: 10.1007/s10895-026-04763-y
International ophtalmology IF: 01.400Volume 46, Issue 1No.99Clinical and demographic characteristics of glaucoma patients in Kingston, Jamaica牙买加金斯敦青光眼患者的临床和人口学特征DOI: 10.1007/s10792-026-04020-y
J Pediatr Endocrinol Metab IF: 01.000Ahead of Print.No.100Psychosocial adaptation of parents of children with type 1 diabetes: a cross-sectional study1型糖尿病患儿父母的心理社会适应：一项横断面研究DOI: 10.1515/jpem-2026-0061
J Pediatr Endocrinol Metab IF: 01.000Ahead of Print.No.101Age and sexual maturation at Spermarche in boys with Laron syndromeLaron综合征男孩首次遗精的年龄与性成熟DOI: 10.1515/jpem-2026-0043
Advances in physiology education IF: 01.700Ahead of Print.No.102The Development and Impact of an Innovative Graduate Program To Promote Entry to Physiology-Related Careers: The Master of Health Science in Medical Physiology创新研究生项目促进生理学相关职业发展的开发与影响：医学生理学健康科学硕士DOI: 10.1152/advan.00060.2026
Diabetes care IF: 16.600Ahead of Print.No.103Misguided Brushes of a Pen Continue to Dismantle and Destroy Biomedical Research in the United States: We Can No Longer Afford Complacency and Fear. We Must All Act Now!错误的笔触持续瓦解和摧毁美国生物医学研究：我们不能再容忍自满与恐惧，必须立即行动！DOI: 10.2337/dci26-0068
Metab Syndr Relat Disord IF: 01.700Ahead of Print.No.104Serum Proenkephalin A as a Marker of Renal Dysfunction and Glycemic Status in Diabetic Nephropathy血清前脑啡肽A作为糖尿病肾病肾功能不全和血糖状态的标志物DOI: 10.1177/15578518261444701
Pancreas IF: 01.700Ahead of Print.No.105Predictive Power of Imaging: Assessing Parenchymal Fibrosis in Pediatric Chronic Pancreatitis影像学预测能力：评估儿童慢性胰腺炎实质纤维化DOI: 10.1097/MPA.0000000000002658
Pol Arch Intern Med IF: 04.700Volume 136, Issue 4No.106Corrections: Assessment of the type 2 diabetes risk using the Finnish Diabetes Risk Score questionnaire, and its predictors at the population level in Poland更正：使用芬兰糖尿病风险评分问卷评估2型糖尿病风险及其在波兰人群水平上的预测因素DOI: 10.20452/pamw.17283
Medical care research and review IF: 02.200Ahead of Print.No.107Defining the Social Needs Service Cascade: Evidence From A Multistakeholder Qualitative Study定义社会需求服务级联：来自多利益相关者定性研究的证据DOI: 10.1177/10775587261439173
Global spine journal IF: 03.000Ahead of Print.No.108Incidence and Risk Factors for 30- and 90-day Reoperations Following Biportal Endoscopic Lumbar Discectomy for Single-Level Lumbar Disc Herniations单节段腰椎间盘突出症双通道内镜下椎间盘切除术后30天和90天再手术的发生率及危险因素DOI: 10.1177/21925682261448186
Plast Reconstr Surg IF: 03.400Ahead of Print.No.109Massive Weight Loss with Bariatric Surgery and GLP-1RA Therapy Predicts Postoperative Complications Following Abdominal Body Contouring减重手术与GLP-1RA治疗导致的巨大体重下降预示腹部塑形术后并发症DOI: 10.1097/PRS.0000000000013015
Inflammopharmacology IF: 05.300Ahead of Print.No.110Dapagliflozin mitigates acute pancreatitis induced by L-arginine in Rats through modulation of TLR-4/NF-κB/NLRP3 pathway: integrated biochemical, histopathological, and in silico study达格列净通过调节TLR-4/NF-κB/NLRP3通路减轻L-精氨酸诱导的大鼠急性胰腺炎：整合生化、组织病理学和计算机模拟研究DOI: 10.1007/s10787-026-02190-w
Am J Physiol Renal Physiol IF: 03.400Ahead of Print.No.111Dapagliflozin ameliorates high-fat diet-induced, megalin-mediated autolysosomal dysfunction in proximal tubules via suppression of megalin-dependent endocytosis达格列净通过抑制megalin依赖性内吞改善高脂饮食诱导的近端肾小管megalin介导的自噬溶酶体功能障碍DOI: 10.1152/ajprenal.00448.2025
Archives of osteoporosis IF: 02.800Volume 21, Issue 1No.112Bone health in young adults with inflammatory arthritis: assessment of associated factors of low bone mineral density年轻成人炎症性关节炎患者的骨骼健康：低骨密度相关因素的评估DOI: 10.1007/s11657-026-01710-z
JAMA psychiatry IF: 17.100Ahead of Print.No.113Semaglutide and Effort-Based Decision-Making in Major Depressive Disorder: A Randomized Clinical Trial司美格鲁肽与重度抑郁症中基于努力的决策：一项随机临床试验DOI: 10.1001/jamapsychiatry.2026.0594
Irish journal of medical science IF: 01.600Ahead of Print.No.114Associations of Mediterranean, DASH, and MIND diet adherence with metabolic parameters in individuals with type 2 diabetes mellitus: a cross-sectional study地中海饮食、DASH饮食和MIND饮食依从性与2型糖尿病患者代谢参数的相关性：一项横断面研究DOI: 10.1007/s11845-026-04415-x
J Egypt Public Health Assoc IF: 02.500Volume 101, Issue 1No.115Psychometric evaluation of the Arabic brief forms of the diabetes distress scale in Egyptian patients with type II diabetes阿拉伯语简短版糖尿病痛苦量表在埃及2型糖尿病患者中的心理测量学评估DOI: 10.1186/s42506-026-00216-3
Retinal cases & brief reportsAhead of Print.No.116Atypical (Three-Quadrant) Central Retinal Vein Occlusion: A Report of two cases and review of literature非典型（三象限）视网膜中央静脉阻塞：两例报告及文献综述DOI: 10.1097/ICB.0000000000001929
Nursing research IF: 02.200Ahead of Print.No.117Perceived Family Support and Treatment Adherence in Older Adults With Type 2 Diabetes老年2型糖尿病患者感知到的家庭支持与治疗依从性DOI: 10.1097/NNR.0000000000000914
Wound repair and regeneration IF: 03.400Volume 34, Issue 3No.118A First-In-Human Study of Pyroligneous Extract, the Biomaterial Derived From Pyrolytic Palm Kernel Shell Wood Vinegar as a Novel Wound Healing Aid on Diabetic Foot Ulcer热解棕榈仁壳木醋液衍生的生物材料——焦木提取物作为糖尿病足溃疡新型伤口愈合辅助剂的首次人体研究DOI: 10.1111/wrr.70166
Multiple sclerosis : IF: 05.000Ahead of Print.No.119Use of semaglutide and tirzepatide among people with multiple sclerosis司美格鲁肽和替尔泊肽在多发性硬化患者中的使用情况DOI: 10.1177/13524585261442033
Food science of animal resources IF: 03.700Volume 44, Issue 1No.120Oral Administration of Lactilactobacillus curvatus LB-P9 Promotes Hair Regeneration in Mice口服弯曲乳杆菌LB-P9促进小鼠毛发再生DOI: 10.5851/kosfa.2023.e74
Clinical transplantation IF: 01.900Volume 40, Issue 5No.121Hypoglycemia Occurrence and Risk Factors in Insulin Independent Patients After Total Pancreatectomy With Islet Autotransplantation全胰腺切除联合胰岛自体移植后胰岛素独立患者低血糖的发生率及危险因素DOI: 10.1111/ctr.70549
Physiology IF: 10.300Ahead of Print.No.122Multicellular Crosstalk and Therapeutic Vaccines in Heart Failure心力衰竭中的多细胞串扰与治疗性疫苗DOI: 10.1152/physiol.00007.2026
JAMA Network Open IF: 09.700Volume 9, Issue 4No.123Hypertrophic Cardiomyopathy and Risk of Out-of-Hospital Cardiac Arrest肥厚型心肌病与院外心脏骤停风险DOI: 10.1001/jamanetworkopen.2026.9673
Am J Physiol Regul Integr Comp Physiol IF: 02.300Ahead of Print.No.124B-Raf is required for normal murine cardiac development and functionB-Raf对小鼠正常心脏发育和功能是必需的DOI: 10.1152/ajpregu.00063.2025
The Prostate IF: 02.500Ahead of Print.No.125Prostate Cancer, Genetic Susceptibility, and Risk of Chronic Non-Urological Complications前列腺癌、遗传易感性与慢性非泌尿系统并发症风险DOI: 10.1002/pros.70190
J Eval Clin Pract IF: 02.100Volume 32, Issue 4No.126A Remote Chronic Disease Management Program to Improve Cardiovascular and Metabolic Outcomes in a Diverse Community-Based Diabetic Population: Study Design of the TAMIS Trial远程慢性病管理项目改善多样化社区糖尿病人群心血管和代谢结局：TAMIS试验研究设计DOI: 10.1111/jep.70456
Cell biochemistry and biophysics IF: 02.500Ahead of Print.No.127Distinct Antibody Signatures to Human Endogenous Retroviruses and Mycobacterium Paratuberculosis in Newly Diagnosed Tunisian Type 1 Diabetes Patients新诊断突尼斯1型糖尿病患者中人内源性逆转录病毒和副结核分枝杆菌的独特抗体特征DOI: 10.1007/s12013-026-02068-2
Journal of Human Hypertension IF: 03.400Ahead of Print.No.128Consensus on the management of hypertension in individuals with diabetes by Asian-Pacific Society of hypertension (APSH) & Diabetes Asia Study Group (DASG).亚太高血压学会与糖尿病亚洲研究组关于糖尿病患者高血压管理的共识DOI: 10.1038/s41371-026-01150-9
JAMA Cardiology IF: 14.100Ahead of Print.No.129Timeliness of Transthyretin Cardiac Amyloidosis Diagnosis in the Medicare Population医疗保险人群中转甲状腺素蛋白心脏淀粉样变性诊断的及时性DOI: 10.1001/jamacardio.2026.0833
JACC IF: 22.300Ahead of Print.No.130Development and Validation of a Clinical Polygenic Risk Report in U.S.-Based Health Systems for 8 Cardiovascular Conditions美国医疗系统中8种心血管疾病临床多基因风险报告的开发与验证DOI: 10.1016/j.jacc.2026.03.035
Mol Cell Biochem IF: 03.700Ahead of Print.No.131Elevated placental inflammation as a mediator of adverse outcomes in gestational diabetes mellitus胎盘炎症升高作为妊娠期糖尿病不良结局的介导因素DOI: 10.1007/s11010-026-05561-7
Irish journal of medical science IF: 01.600Ahead of Print.No.132Reduced fetal MAPSE and TAPSE in gestational diabetes mellitus: a prospective case-control study妊娠期糖尿病胎儿二尖瓣环收缩期位移与三尖瓣环收缩期位移降低：一项前瞻性病例对照研究DOI: 10.1007/s11845-026-04426-8
Soc Psychiatry Psychiatr Epidemiol IF: 03.500Ahead of Print.No.133Association between maternal pregnancy complications and long-term depressive and anxiety disorders: evidence from the UK millennium cohort study母体妊娠并发症与长期抑郁和焦虑障碍的关联：来自英国千禧队列研究的证据DOI: 10.1007/s00127-026-03094-4
JAHA IF: 05.300Ahead of Print.No.134Acute Impact of Transcatheter Edge-to-Edge Repair of Tricuspid Regurgitation on Right Ventricular Hemodynamics经导管缘对缘修复三尖瓣反流对右心室血流动力学的急性影响DOI: 10.1161/JAHA.125.047560
Endokrynologia Polska IF: 02.100Volume 77, Issue 2No.135Eradicating hyperandrogenism? Hormonal changes following Helicobacter pylori eradication in women with polycystic ovary syndrome: an observational case series根除幽门螺杆菌后多囊卵巢综合征女性的激素变化：一项观察性病例系列研究DOI: 10.5603/ep.110428
Saudi pharmaceutical journal IF: 03.400Volume 34, Issue 2No.136Efficacy and safety of pharmacological and procedural interventions in the management of hypertriglyceridemia-induced acute pancreatitis: a systematic review药物和介入干预治疗高甘油三酯血症诱导的急性胰腺炎的有效性和安全性：一项系统评价DOI: 10.1007/s44446-026-00078-y
Kaohsiung J Med Sci IF: 03.100Ahead of Print.No.137Efficacy of CPAP Therapy on Liver Steatosis and Insulin Resistance in Fatty Liver Patients With Obstructive Sleep Apnea: A 4-Year Follow-Up Cohort StudyCPAP治疗对阻塞性睡眠呼吸暂停合并脂肪性肝病患者肝脏脂肪变性和胰岛素抵抗的有效性：一项4年随访队列研究DOI: 10.1002/kjm2.70222
JAHA IF: 05.300Ahead of Print.No.138Glucose-6-Phosphate Dehydrogenase Modifies the Impact of Glucose on Arterial Aging in A Sex-Specific Manner葡萄糖-6-磷酸脱氢酶以性别特异性方式调节葡萄糖对动脉老化的影响DOI: 10.1161/JAHA.125.045538
JAMA IF: 55.000Ahead of Print.No.139Pigmentary Changes That Developed During Pregnancy妊娠期色素沉着变化DOI: 10.1001/jama.2026.2928
Rev Endocr Metab Disord IF: 08.000Ahead of Print.No.140Hypothalamic regulation of energy homeostasis: Quo vadis下丘脑对能量稳态的调控：何去何从DOI: 10.1007/s11154-026-10042-9
Obesity surgery IF: 03.100Ahead of Print.No.141Food Consumption by Processing Levels in Adults Two or More Years After Sleeve Gastrectomy: Associations with Surgical Outcomes and Eating Behaviors袖状胃切除术后两年及以上成年人按加工级别分类的食物消费：与手术结局和饮食行为的关联DOI: 10.1007/s11695-026-08582-9
Cell biochemistry and biophysics IF: 02.500Ahead of Print.No.142Effects of Diet-Induced Obesity and Exercise Intervention on Testicular Germ Cell Health: Modulation of SIRT1/FoxO1 and SIRT1/PGC-1α Signaling Axes饮食诱导肥胖与运动干预对睾丸生殖细胞健康的影响：SIRT1/FoxO1和SIRT1/PGC-1α信号轴的调节DOI: 10.1007/s12013-026-02076-2
BJS open IF: 04.500Volume 10, Issue 2No.143Sleeve gastrectomy versus Roux-en-Y-gastric bypass in patients with body mass index over 50 kg/m2: international multicentre cohort袖状胃切除术与Roux-en-Y胃旁路术在体重指数超过50 kg/m²患者中的比较：国际多中心队列研究DOI: 10.1093/bjsopen/zrag028
J Clin Pharmacol IF: 02.300Volume 66, Issue 5No.144Assessment of the Drug-Drug Interaction Potential of Lotiglipron (PF-07081532) with Midazolam, Omeprazole, Dabigatran, Rosuvastatin, and the Oral Contraceptives Levonorgestrel and Ethinyl Estradiol评估Lotiglipron（PF-07081532）与咪达唑仑、奥美拉唑、达比加群、瑞舒伐他汀以及口服避孕药左炔诺孕酮和炔雌醇的药物相互作用潜力DOI: 10.1002/jcph.70158
Health informatics journal IF: 02.300Volume 32, Issue 2No.145An informatics-based data-led prioritization strategy to facilitate objective and equitable care for an ethnically diverse urban cohort of people with type 1 diabetes: A proof-of-concept study基于信息学的数据主导优先排序策略：为种族多样化的城市1型糖尿病患者群体提供客观公平护理的概念验证研究DOI: 10.1177/14604582261436276
Crit Rev Food Sci Nutr IF: 08.800Ahead of Print.No.146A scoring system for validity assessment of biomarkers of food intake食物摄入生物标志物有效性评估评分系统DOI: 10.1080/10408398.2026.2633561
Nutrition and health IF: 01.400Ahead of Print.No.147Influence of autonomic function on the thermic effect of food and postprandial insulin sensitivity in individuals with obesity, submitted to a test meal with or without ultra-processed foods: Secondary analysis of a randomized trial自主神经功能对肥胖个体食物热效应和餐后胰岛素敏感性的影响：一项随机试验的二次分析DOI: 10.1177/02601060261446525
Nutrition reviews IF: 04.900Ahead of Print.No.148Methyl Donor Nutrient Intake as a Modulator of the Association between FTO Gene Variants and BMI: A Systematic Review with Meta-Analysis and Meta-Regression甲基供体营养素摄入作为FTO基因变异与体重指数之间关联的调节因素：系统综述、荟萃分析和荟萃回归DOI: 10.1093/nutrit/nuag035
Journal of human lactation : IF: 01.800Ahead of Print.No.149Linking Early Infant Growth With Milk-Derived Antibodies, Hormones, and Macronutrients During Exclusive Breastfeeding纯母乳喂养期间早期婴儿生长与母乳中抗体、激素和宏量营养素的关联DOI: 10.1177/08903344261430138
Open Heart IF: 02.800Volume 13, Issue 1No.150Are clinical improvements in anxiety or depression associated with improvement in walking fitness following a cardiac rehabilitation programme?心脏康复计划后焦虑或抑郁的临床改善是否与步行能力的改善相关？DOI: 10.1136/openhrt-2026-004051
Thyroid research IF: 01.800Volume 19, Issue 1No.151Measuring thyroid-stimulating hormone receptor antibodies using the IMMULITE(®) 2000 TSI assay is better than using the BRAHMS TRAK assay in an unselected clinical population, but both perform worse than expected: a real-world retrospective observational study在未经筛选的临床人群中，使用IMMULITE® 2000 TSI检测法测量促甲状腺激素受体抗体优于BRAHMS TRAK检测法，但两者表现均低于预期：一项真实世界回顾性观察研究DOI: 10.1186/s13044-026-00296-5
Int J Reprod Biomed IF: 01.800Volume 24, Issue 2No.152Therapeutic effects of Foeniculum vulgare and Achillea millefolium on ovarian function in a mouse model of polycystic ovary syndrome: An experimental study茴香和蓍草对多囊卵巢综合征小鼠模型卵巢功能的治疗作用：一项实验研究DOI: 10.18502/ijrm.v24i2.21053
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.153Molecular mechanisms of insulin resistance and altered carbohydrate metabolism in PCOS: a scoping review多囊卵巢综合征胰岛素抵抗与碳水化合物代谢改变的分子机制：一项范围综述DOI: 10.3389/fendo.2026.1810805
bioRxivVolume 2026, Issue No.154Distinct Molecular Mechanisms Regulate Feeding State-Dependent CO (2) Chemotaxis Plasticity During Different Life Stages in Caenorhabditis elegans不同生命阶段中进食状态依赖的CO2趋化可塑性的不同分子机制DOI: 10.64898/2026.02.06.704338
BMC research notes IF: 01.700Ahead of Print.No.155In vitro assessment of the impact of di(2-ethylhexyl) phthalate and its metabolites on the function and transcription of key glucose sensing proteins in a rat pancreatic β-cell line邻苯二甲酸二(2-乙基己基)酯及其代谢物对大鼠胰腺β细胞系关键葡萄糖感应蛋白功能和转录影响的体外评估DOI: 10.1186/s13104-026-07830-6
JACC: AdvancesVolume 5, Issue 5No.156Characteristics, Management, and Outcomes of Diabetes Subtypes in Patients With Cardiogenic Shock心源性休克患者糖尿病亚型的特征、管理及主要终点DOI: 10.1016/j.jacadv.2026.102766
Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.157Prognostic value of advanced imaging biomarkers for the progression of diabetic retinopathy: a systematic review先进影像生物标志物对糖尿病视网膜病变进展的预后价值：一项系统评价DOI: 10.1186/s13098-026-02159-3
Current obesity reports IF: 11.000Volume 15, Issue 1No.158The Epidemiology of the Global Syndemic in Africa: New Evidence and Key Insights非洲全球共病流行病学：新证据与关键见解DOI: 10.1007/s13679-026-00717-4
Frontiers in health services IF: 02.700Volume 6, Issue No.159Therapeutic intensity and patient-reported outcomes among heart failure patients in a pharmacist-led medication therapy adherence clinic program in Malaysia马来西亚药师主导的药物治疗依从性门诊项目中心力衰竭患者的治疗强度与患者报告结局DOI: 10.3389/frhs.2026.1784432
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.160Acromegalic features and hypoglycemia: Doege-Potter syndrome肢端肥大症特征与低血糖：Doege-Potter综合征DOI: 10.22088/cjim.17.1.205
JCEM case reportsVolume 4, Issue 5No.161A rare case of dual hormone-secreting pulmonary neuroendocrine tumor causing concurrent Cushing syndrome and acromegaly一例罕见的双重激素分泌性肺神经内分泌肿瘤导致库欣综合征和肢端肥大症并存DOI: 10.1210/jcemcr/luag092
Journal of Hypertension IF: 04.100Volume 44, Issue 6No.162Response to letter 'Sex-specific associations between TyG index and emotional states'对《TyG指数与情绪状态的性别特异性关联》一信的回复DOI: 10.1097/HJH.0000000000004289
Int J Eat Disord IF: 04.300Ahead of Print.No.163Sex Differences in Social, Health, and Lifestyle Characteristics Associated With Binge-Eating Behaviors: Results From a French National Random Population-Based Study与暴食行为相关的社会、健康和生活方式特征的性别差异：基于法国全国随机人群研究的结果DOI: 10.1002/eat.70113
J Integr Neurosci IF: 02.700Volume 25, Issue 4No.164Lipid Ratio Biomarkers as Protective Factors for Depressive Symptoms in Newly Diagnosed Metabolic Syndrome: Evidence From Regression Modeling脂质比值生物标志物作为新诊断代谢综合征患者抑郁症状的保护因素：来自回归模型的证据DOI: 10.31083/JIN49628
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.165The association between appendicular skeletal muscle index and liver steatosis and fibrosis: A cross-sectional study四肢骨骼肌指数与肝脏脂肪变性和纤维化的关联：一项横断面研究DOI: 10.22088/cjim.17.1.113
Front Sports Act Living IF: 02.600Volume 8, Issue No.166Physiological and cortical determinants of exercise tolerance in sedentary women with obesity久坐肥胖女性运动耐量的生理和皮层决定因素DOI: 10.3389/fspor.2026.1771921
Int J Womens Health IF: 02.600Volume 18, Issue No.167Comparison of Surgical Outcomes Among Open, Laparoscopic, and Robotic Surgeries in Women with Obesity Diagnosed with Endometrial Cancer: Results from a Quaternary Hospital in Thailand肥胖子宫内膜癌患者开腹、腹腔镜与机器人手术结局比较：泰国一家四级医院的结果DOI: 10.2147/IJWH.S598487
JBMR plus IF: 02.400Volume 10, Issue 5No.168Pain medication use in patients with X-linked hypophosphatemia treated with burosumab: a retrospective real-world study布罗索尤单抗治疗X连锁低磷血症患者的止痛药使用：一项回顾性真实世界研究DOI: 10.1093/jbmrpl/ziag047
Journal of affective disorders reportsVolume 24, Issue No.169Insights from deep learning models on new-onset anxiety in patients following bariatric metabolic surgery深度学习模型对减重代谢手术后新发焦虑的洞察DOI: 10.1016/j.jadr.2026.101061
Frontiers in psychology IF: 02.900Volume 17, Issue No.170Didactic adaptation of basketball in physical education to reduce anxiety and emotional eating in adolescent girls with obesity: a randomized controlled trial体育教育中篮球教学适应性改编对肥胖青少年女性焦虑和情绪性进食的影响：一项随机对照试验DOI: 10.3389/fpsyg.2026.1753266
Front Behav Neurosci IF: 02.900Volume 20, Issue No.171Revisiting food addiction in the era of GLP-1-based obesity pharmacotherapy via neural reward pathways linking feeding and substance use在基于GLP-1的肥胖药物治疗时代重新审视食物成瘾：通过连接进食与物质使用的神经奖赏通路DOI: 10.3389/fnbeh.2026.1805953
J Diabetes Investig IF: 03.000Ahead of Print.No.172Validation of the ST1RE risk engine in Chinese with type 1 diabetes and comparison with the JADE, RECODe, and UKPDS risk scoresST1RE风险引擎在中国1型糖尿病患者中的验证及与JADE、RECODe和UKPDS风险评分的比较DOI: 10.1111/jdi.70316
British journal of nutrition IF: 03.000Ahead of Print.No.173Patterns of dietary habits are associated with metabolic health status in adults膳食习惯模式与成人代谢健康状态相关DOI: 10.1017/S0007114526106722
Mol Nutr Food Res IF: 04.200Volume 70, Issue 9No.174Maternal Chrono-Nutrition and Placental DNA Methylation: The BiSC Study母亲时间营养与胎盘DNA甲基化：BiSC研究DOI: 10.1002/mnfr.70465
Lipids IF: 01.600Ahead of Print.No.175Hepatic Lipids as Molecular Targets in Obesity-Associated Insulin Resistance in Rodent Models: A Systematic Review and Meta-Analysis啮齿动物模型中肝脏脂质作为肥胖相关胰岛素抵抗的分子靶点：系统综述与荟萃分析DOI: 10.1002/lipd.70061
J Diabetes Investig IF: 03.000Ahead of Print.No.176Time in range during caloric restriction in type 2 diabetes with obesity肥胖2型糖尿病患者热量限制期间的血糖在目标范围内时间DOI: 10.1111/jdi.70308
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.177Indirect Comparative Efficacy and Safety of Tirzepatide Versus Oral Semaglutide for the Treatment of Overweight and Obesity替尔泊肽与口服司美格鲁肽治疗超重和肥胖的间接比较有效性和安全性DOI: 10.1111/dom.70773
British journal of nutrition IF: 03.000Ahead of Print.No.178Contribution of meals to energy and nutrient intakes and implication of skipping meals on nutritional status among primary schoolchildren in Malaysia马来西亚小学生膳食对能量和营养素摄入的贡献及不吃饭对营养状况的影响DOI: 10.1017/S0007114526107314
J Health Popul Nutr IF: 02.800Ahead of Print.No.179Malnutrition among men in Ghana: socio-demographic factors and rural-urban differences加纳男性营养不良：社会人口因素与城乡差异DOI: 10.1186/s41043-026-01325-7
Allergy IF: 12.000Ahead of Print.No.180Longitudinal Follow-Up of Gut and Salivary Microbiota in Children With Food Protein-Induced Enterocolitis Syndrome食物蛋白诱导性小肠结肠炎综合征患儿肠道和唾液微生物群的纵向随访DOI: 10.1111/all.70363
Frontiers in bioscience IF: 03.100Volume 31, Issue 4No.181Potential Application of HIF-PH Inhibitors to Treat Kidney DiseasesHIF-PH抑制剂治疗肾脏疾病的潜在应用DOI: 10.31083/FBL47718
Frontiers in bioscience IF: 03.100Volume 31, Issue 4No.182The Gut-Lung Axis, Epigenetics and Respiratory Disease肠-肺轴、表观遗传学与呼吸系统疾病DOI: 10.31083/FBL48743
Revista de neurología IF: 00.800Volume 81, Issue 4No.183Peripheral Neuropathy: A Phenotype-Driven Review for Diagnosis and Management周围神经病变：基于表型的诊断与管理综述DOI: 10.31083/RN48384
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.184Investigating the effect of pirfenidone on lung CT scans in patients with severe COVID-19 Hospitalized at Shahid Sadoughi Hospital, Yazd, Iran吡非尼酮对重症COVID-19患者肺部CT扫描影响的研究DOI: 10.22088/cjim.17.1.163
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.185Detecting coronary artery disease among the individuals with left-sided dominant coronary circulation左侧优势型冠状动脉循环个体中冠状动脉疾病的检测DOI: 10.22088/cjim.17.1.173
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.186Association of interleukin-8 and neutrophil-to-lymphocyte ratio with clinical indices in diabetic nephropathy白细胞介素-8和中性粒细胞与淋巴细胞比值与糖尿病肾病临床指标的相关性DOI: 10.22088/cjim.17.1.191
Sleep AdvVolume 7, Issue 2No.187Using consumer sleep trackers for sleep extension interventions: retention, adherence, and user experiences使用消费者睡眠追踪器进行睡眠延长干预：保留率、依从性和用户体验DOI: 10.1093/sleepadvances/zpag025
Health science reports IF: 02.100Volume 9, Issue 5No.188How Pre-Pregnancy Weight and Polycystic Ovary Syndrome Impact Pregnancy Outcomes: A Population-Based Cohort Study孕前体重与多囊卵巢综合征对妊娠结局的影响：一项基于人群的队列研究DOI: 10.1002/hsr2.72088
Frontiers in ophthalmologyVolume 6, Issue No.189Use of preoperative swept-source optical coherence tomography in vitrectomy for advanced diabetic eye disease: a pilot study术前扫频源光学相干断层扫描在晚期糖尿病眼病玻璃体切除术中的应用：一项初步研究DOI: 10.3389/fopht.2026.1688660
Clin Med Insights Endocrinol Diabetes IF: 03.000Volume 19, Issue No.190Euthyroid Sick Syndrome Precipitated By Rapid Weight Loss Following Semaglutide Initiation: A Case Report司美格鲁肽治疗后快速减重诱发正常甲状腺病态综合征：一例病例报告DOI: 10.1177/11795514261443862
RSC advances IF: 04.600Volume 16, Issue 24No.191Bacterial metabolite-directed synthesis of biogenic TiO(2)-Zn nanocomposites: characterization and multifunctional biomedical evaluation细菌代谢物导向合成生物源TiO₂-Zn纳米复合材料：表征与多功能生物医学评价DOI: 10.1039/d6ra00881j
Frontiers in chemistry IF: 04.200Volume 14, Issue No.192Phytochemical profiling and multi-target pharmacological evaluation of Symphyotrichum squamatum unveils its potential as a source of antidiabetic and anti-inflammatory agentsSymphyotrichum squamatum的植物化学谱系及多靶点药理学评价揭示其作为抗糖尿病和抗炎药物来源的潜力DOI: 10.3389/fchem.2026.1734411
J Pharm Policy Pract IF: 02.500Volume 19, Issue 1No.193Asthma and chronic obstructive disease overlap (ACO), a systematic review of prevalence and co-morbidity factors based on diagnostic criteria哮喘与慢性阻塞性肺疾病重叠（ACO）：基于诊断标准的患病率和共病因素系统综述DOI: 10.1080/20523211.2026.2654490
J Pharm Policy Pract IF: 02.500Volume 19, Issue 1No.194The prevalence and predictor factors of urinary tract infection in type 2 diabetes mellitus patients receiving SGLT2 inhibitors in Qatar: A retrospective cohort study卡塔尔2型糖尿病患者使用SGLT2抑制剂后尿路感染的患病率及预测因素：一项回顾性队列研究DOI: 10.1080/20523211.2026.2645913
Frontiers in public health IF: 03.400Volume 14, Issue No.195Central adiposity outperforms disordered eating behavior in predicting type 2 diabetes risk in young adults: an explainable machine learning approach中心性肥胖在预测年轻人2型糖尿病风险方面优于饮食行为紊乱：一项可解释机器学习方法DOI: 10.3389/fpubh.2026.1778156
Frontiers in public health IF: 03.400Volume 14, Issue No.196Correction: Influence of the COVID-19 pandemic on chronic disease management among indigenous people in Canada更正：COVID-19大流行对加拿大原住民慢性病管理的影响DOI: 10.3389/fpubh.2026.1817733
Int J Microbiol IF: 03.200Volume 2026, Issue No.197Coevolution of Human Diet and Gut Microbiome: Implications for Nutrigenomics and Cross-Population Health人类饮食与肠道微生物组的共同进化：对营养基因组学和跨人群健康的影响DOI: 10.1155/ijm/5597426
Germs IF: 01.700Volume 16, Issue 1No.198Variety of Clostridioides difficile Ribotypes in CDI Patients in Las Vegas, NV内华达州拉斯维加斯CDI患者中艰难梭菌核糖体类型的多样性DOI: 10.3390/germs16010002
Curēus IF: 01.300Volume 18, Issue 3No.199Elevated Lipoprotein(a) and Cardiovascular Outcomes After Percutaneous Coronary Intervention: A Systematic Review经皮冠状动脉介入治疗后脂蛋白(a)升高与心血管结局：一项系统评价DOI: 10.7759/cureus.106009
Curēus IF: 01.300Volume 18, Issue 3No.200Early-Remitting Neonatal Diabetes in a Growth-Restricted Preterm Infant Requiring Insulin: A Case Report生长受限早产儿需胰岛素治疗的早期缓解型新生儿糖尿病：一例病例报告DOI: 10.7759/cureus.106025
Frontiers in physiology IF: 03.400Volume 17, Issue No.201Modulation of the serotonergic system restores oxidative balance and gene expression in the brain and heart of rats with obesity induced by overnutrition血清素系统调节恢复营养过剩诱导肥胖大鼠脑和心脏的氧化平衡与基因表达DOI: 10.3389/fphys.2026.1783080
Frontiers in medicine IF: 03.000Volume 13, Issue No.202Systemic strategies to prevent early diabetic retinopathy: targeting polyunsaturated fatty acid metabolism and eicosanoid signaling预防早期糖尿病视网膜病变的系统性策略：靶向多不饱和脂肪酸代谢和类花生酸信号DOI: 10.3389/fmed.2026.1802443
J Clin Exp DentVolume 18, Issue 3No.203Nonsurgical Periodontal Therapy for Diabetes Patients with Periodontal Disease非手术牙周治疗对伴有牙周病的糖尿病患者的疗效DOI: 10.4317/jced.63729
J Public Health ResVolume 15, Issue 2No.204Understanding community needs: Comprehensive analysis of the family adoption program conducted in coastal region of South India理解社区需求：印度南部沿海地区家庭收养计划的综合分析DOI: 10.1177/22799036261439972
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.205Relationship between apolipoprotein M levels and diabetic retinopathy in patients with type 2 diabetes mellitus2型糖尿病患者载脂蛋白M水平与糖尿病视网膜病变的关系DOI: 10.3389/fendo.2026.1809680
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.206Dermatologic outcomes associated with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a large-scale target trial emulation胰高血糖素样肽-1受体激动剂与2型糖尿病患者皮肤结局的关联：一项大规模目标试验模拟研究DOI: 10.3389/fendo.2026.1801203
Frontiers in digital health IF: 03.800Volume 8, Issue No.207ChatGPT for diabetes education: potential, accuracy, and accessibility in patient supportChatGPT在糖尿病教育中的应用：患者支持中的潜力、准确性与可及性DOI: 10.3389/fdgth.2026.1768843
bioRxivVolume 2026, Issue No.208Longitudinal in vivo human wound healing model defines key role for smooth muscle cells in ECM remodeling纵向体内人类伤口愈合模型定义平滑肌细胞在细胞外基质重塑中的关键作用DOI: 10.64898/2026.02.24.707845
JCEM case reportsVolume 4, Issue 5No.209Tirzepatide-associated hyponatremia in a patient with known arginine vasopressin deficiency替尔泊肽相关低钠血症在一例已知精氨酸加压素缺乏症患者中的报告DOI: 10.1210/jcemcr/luag110
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.210The therapeutic potential of Vanilla planifolia: how its phytochemicals combat diabetes?香荚兰的治疗潜力：其植物化学物质如何对抗糖尿病？DOI: 10.3389/fphar.2026.1752315
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.211Correction: Alpha-7 nicotinic acetylcholine receptor: targeting the interplay between inflammation, renin-angiotensin aldosterone system, and nervous system for the novel treatment of heart failureα7烟碱型乙酰胆碱受体：靶向炎症、肾素-血管紧张素-醛固酮系统与神经系统之间的相互作用用于心力衰竭的新型治疗DOI: 10.3389/fphar.2026.1841172
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.212The role of chromogranin A cleavage products in onset of type 1 and 2 diabetes嗜铬粒蛋白A裂解产物在1型和2型糖尿病发病中的作用DOI: 10.3389/fcdhc.2026.1812936
Diabetic medicine IF: 03.400Ahead of Print.No.213Considerations for the clinical use of teplizumab in stage 2 Type 1 diabetes: A Consensus Statement from the British Society of Paediatric Endocrinology and Diabetes (BSPED) and the Association of British Clinical Diabetologists (ABCD)替普利珠单抗在2型1型糖尿病临床应用的考量：英国儿科内分泌与糖尿病学会和英国临床糖尿病专家协会的共识声明DOI: 10.1111/dme.70329
Diabetic medicine IF: 03.400Ahead of Print.No.214Has the time come for a remission definition in type 1 diabetes? A functional perspective1型糖尿病缓解定义时机已到？功能性视角DOI: 10.1111/dme.70351
Cent Nerv Syst Agents Med ChemAhead of Print.No.215Unveiling the Neuroprotective Role of Nutritional Supplements in Neurodegenerative Diseases揭示营养补充剂在神经退行性疾病中的神经保护作用DOI: 10.2174/0118715249389608251108031453
British journal of nutrition IF: 03.000Ahead of Print.No.216Association between the Mediterranean dietary pattern and Metabolic dysfunction-associated steatotic liver disease (MASLD): A longitudinal analysis from UK BIOBANK地中海饮食模式与代谢功能障碍相关脂肪性肝病的关联：来自英国生物样本库的纵向分析DOI: 10.1017/S0007114526107351
Curr Opin Endocrinol Diabetes Obes IF: 02.700Volume 33, Issue 3No.217Editorial introduction编者按DOI: 10.1097/MED.0000000000000958
Medical decision making : IF: 02.300Ahead of Print.No.218A Microsimulation-Based Approach for Mitigating Societal Bias in Chronic Kidney Disease Data基于微观模拟的慢性肾脏病数据社会偏见缓解方法DOI: 10.1177/0272989X261432162
The journal of dermatology IF: 02.700Ahead of Print.No.219Drug-Induced Blaschkitis Associated With Dipeptidyl Peptidase-4 Inhibitor: A Case Report and Review of the Literature二肽基肽酶-4抑制剂相关药物诱导的Blaschkitis：病例报告及文献综述DOI: 10.1111/1346-8138.70296
Diabetes Technol Ther IF: 06.300Ahead of Print.No.220Safety and Effectiveness of MiniMed™ 780G Advanced Hybrid Closed-Loop Use with Ultrarapid Insulin Lispro-AABC in Pediatric and Adult Type 1 DiabetesMiniMed™ 780G高级混合闭环系统联合超速效胰岛素赖脯-aabc在儿童和成人1型糖尿病患者中的安全性和有效性DOI: 10.1177/15209156261444994
BMC nutrition IF: 02.200Ahead of Print.No.221Dietary advanced glycation end products and risk of cardiometabolic disorders in older adults: cross-sectional data from the 2007-2021 Korea National Health and Nutrition Examination Survey (KNHANES)膳食晚期糖基化终末产物与老年人心脏代谢疾病风险：基于2007-2021年韩国国家健康与营养调查的横断面数据DOI: 10.1186/s40795-026-01334-z
Frontiers in public health IF: 03.400Volume 14, Issue No.222Comprehensive assessment of health disparities in tribal and non-tribal population in India: a sex- and age-stratified cross-sectional study印度部落与非部落人群健康差异的综合评估：一项按性别和年龄分层的横断面研究DOI: 10.3389/fpubh.2026.1772205
Current drug metabolism IF: 01.800Ahead of Print.No.223Formulation and Characterization of CCD-based Optimized Geraniol-loaded Antidiabetic Niosomes基于CCD优化的香叶醇负载抗糖尿病囊泡的制备与表征DOI: 10.2174/0113892002382359251122043509
Immunopharmacol Immunotoxicol IF: 03.000Ahead of Print.No.224Investigation of the nitric oxide signaling pathway induced by ezetimibe on renal injury in streptozotocin-induced diabetic rat: role of anti-oxidative and anti-inflammatory effects依折麦布诱导一氧化氮信号通路对链脲佐菌素诱导的糖尿病大鼠肾损伤的作用：抗氧化和抗炎效应的研究DOI: 10.1080/08923973.2026.2657952
Critical care IF: 09.300Volume 30, Issue 1No.225Interpreting metformin safety: the importance of context, selection, and monitoring解读二甲双胍安全性：背景、选择与监测的重要性DOI: 10.1186/s13054-026-06050-5
Curēus IF: 01.300Volume 18, Issue 3No.226THR-β Agonists vs Incretin Therapies for Noncirrhotic Metabolic Dysfunction-Associated Steatohepatitis (MASH): A Biopsy-Anchored Systematic Review With Grading of Recommendations Assessment, Development and Evaluation (GRADE) CertaintyTHR-β激动剂与肠促胰素疗法治疗非肝硬化性代谢功能障碍相关脂肪性肝炎：一项基于活检的系统评价与GRADE证据确定性评估DOI: 10.7759/cureus.106038
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.227Monocytes in HIV associated atherosclerosis: A review of pathogenesis and clinical implications单核细胞在HIV相关动脉粥样硬化中的作用：发病机制与临床意义综述DOI: 10.22088/cjim.17.1.1
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.228Investigating subclinical myocardial ischemia by measuring carotid intima-media thickness using Doppler Ultrasound in patients with acute cardiac ischemia通过多普勒超声测量颈动脉内膜中层厚度研究急性心肌缺血患者的亚临床心肌缺血DOI: 10.22088/cjim.17.1.97
Trials IF: 02.000Ahead of Print.No.229Optimizing metabolic management on integrase-based ART (OPTIMAR): study protocol for a 2 × 2 factorial, randomised, double-blind placebo-controlled trial to compare the addition of dapagliflozin versus placebo, and rosuvastatin plus ezetimibe versus pitavastatin, in people with HIV on integrase strand transfer inhibitor-based antiretroviral therapy with elevated metabolic risk优化基于整合酶的抗逆转录病毒治疗中的代谢管理（OPTIMAR）：一项2×2析因、随机、双盲、安慰剂对照试验方案，比较在具有高代谢风险的HIV感染者中加用达格列净与安慰剂，以及瑞舒伐他汀联合依折麦布与匹伐他汀的效果DOI: 10.1186/s13063-026-09723-2
RSC advances IF: 04.600Volume 16, Issue 24No.230Novel piperazine-triazole hybrids as PTP1B and alpha-amylase inhibitors: synthesis, biological evaluation and computational validation through network pharmacology, molecular docking, MD simulations, DFT and MMPBSA analysis新型哌嗪-三唑杂合物作为PTP1B和α-淀粉酶抑制剂：合成、生物学评价及通过网络药理学、分子对接、MD模拟、DFT和MMPBSA分析的计算验证DOI: 10.1039/d6ra00931j
Clinical Research in Cardiology IF: 03.700Ahead of Print.No.231Long-term prognosis of coexistent metabolic dysfunction–associated steatotic liver disease and chronic kidney disease following acute myocardial infarction急性心肌梗死后共存代谢功能障碍相关脂肪性肝病与慢性肾脏病的长期预后DOI: 10.1007/s00392-026-02925-3
JSCAIAhead of Print.No.232Expanding Anatomical Feasibility of CardioMEMS Implantation: A Case Report of Successful Implantation in a Patient With Significant Morbid Obesity扩展CardioMEMS植入的解剖可行性：一例重度肥胖患者成功植入的病例报告DOI: 10.1016/j.jscai.2026.105319
236
Diabetes Mellitus(DM)
糖尿病
93
Obesity
肥胖症
63
Insulin
胰岛素
27
Type 2 diabetes mellitus(T2DM)
2型糖尿病
14
Metabolic Syndrome
代谢综合征
14
Diabetic Foot
糖尿病足
12
Metformin
二甲双胍
11
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
11
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
11
Diabetic Retinopathy
糖尿病视网膜病
9
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
8
Diabetic Neuropathies
糖尿病性神经病变
7
Semaglutide
司美格鲁肽
7
Hypoglycemic Agents
降糖药
5
Type 1 diabetes mellitus(T1DM)
1型糖尿病
5
Tirzepatide
替尔泊肽
5
Diabetes Complications
糖尿病并发症
5
Diabetic Peripheral Neuropathy(PDN)
糖尿病周围神经病变
4
Pregabalin
普瑞巴林
4
Dapagliflozin
达格列净
2
Ertugliflozin
艾托格列净
2
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
2
Liraglutide
利拉鲁肽
2
Sitagliptin
西他列汀
2
Gabapentin
加巴喷丁
2
Diabetic acidosis
糖尿病性酸中毒
2
Diabetic Cardiomyopathies
糖尿病心肌病
2
Painful Diabetic Peripheral Neuropathy(PDPN)
痛性糖尿病周围神经病变
1
gamma-Aminobutyric Acid(GABA)
γ-氨基丁酸
1
Canagliflozin
卡格列净
1
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
1
Vildagliptin
维格列汀
编辑：韩玉莲
审校：韩玉莲
100 项与 盐酸吡格列酮 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 2型糖尿病 | 美国 | 1999-07-15 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 神经性听力损失 | 临床3期 | 捷克 | 2017-06-27 | |
| 突发性听力损失 | 临床3期 | 捷克 | 2017-06-27 | |
| 阿尔茨海默症 | 临床3期 | 美国 | 2013-08-01 | |
| 阿尔茨海默症 | 临床3期 | 澳大利亚 | 2013-08-01 | |
| 阿尔茨海默症 | 临床3期 | 德国 | 2013-08-01 | |
| 阿尔茨海默症 | 临床3期 | 瑞士 | 2013-08-01 | |
| 阿尔茨海默症 | 临床3期 | 英国 | 2013-08-01 | |
| 轻度认知障碍 | 临床3期 | 美国 | 2013-08-01 | |
| 轻度认知障碍 | 临床3期 | 澳大利亚 | 2013-08-01 | |
| 轻度认知障碍 | 临床3期 | 德国 | 2013-08-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床4期 | - | 9 | (Pioglitazone) | 蓋構構範壓憲製憲獵築(積獵願鑰製構廠衊餘窪) = 艱鑰鏇淵觸窪憲積構網 淵鑰夢鹽廠憲艱憲積鹽 (鏇觸鑰憲鏇鏇獵簾窪遞, 0.03) 更多 | - | 2026-03-19 | |
Placebo (Placebo) | 蓋構構範壓憲製憲獵築(積獵願鑰製構廠衊餘窪) = 醖鑰積蓋製醖鏇膚觸製 淵鑰夢鹽廠憲艱憲積鹽 (鏇觸鑰憲鏇鏇獵簾窪遞, 0.09) 更多 | ||||||
临床1/2期 | 67 | Placebo (Placebo) | 壓憲鏇鑰鑰蓋艱膚糧衊(醖膚齋鬱範築餘糧繭壓) = 範築糧鹽艱齋繭鑰夢獵 鏇鑰鏇夢願醖蓋醖淵淵 (壓糧壓夢遞廠願鏇範廠, 11.426) 更多 | - | 2025-08-27 | ||
(Pioglitazone) | 壓憲鏇鑰鑰蓋艱膚糧衊(醖膚齋鬱範築餘糧繭壓) = 遞廠鹹窪糧築製襯壓憲 鏇鑰鏇夢願醖蓋醖淵淵 (壓糧壓夢遞廠願鏇範廠, 11.885) 更多 | ||||||
早期临床1期 | 14 | 鏇淵膚襯製襯選築鹽餘(築觸簾艱襯糧繭製壓窪) = 衊網顧餘積選膚鹹鏇鏇 網獵繭膚繭襯窪繭簾鹹 (鹽憲壓鏇壓憲鹹鏇鏇築, 0.9) 更多 | - | 2025-04-30 | |||
临床4期 | 26 | (2000-200 Study 10-day Pioglitazone) | 願鏇淵構淵鏇顧觸獵築(鏇築繭簾憲醖襯窪繭積) = 鹽構鑰鹹鑰鑰願範淵鏇 艱窪積醖觸膚願膚選鹽 (淵憲艱獵製觸餘壓願壓, 0.19) 更多 | - | 2025-03-03 | ||
placebo+pioglitazone (2000-200 Study 10-day Placebo) | 願鏇淵構淵鏇顧觸獵築(鏇築繭簾憲醖襯窪繭積) = 廠襯範築鑰願構壓襯鏇 艱窪積醖觸膚願膚選鹽 (淵憲艱獵製觸餘壓願壓, 0.20) 更多 | ||||||
临床4期 | 糖尿病 追加 | 55 | 鬱壓遞鹹窪夢膚艱構膚(觸製壓願願鹽鑰網願構) = 窪製醖積積窪簾襯鏇築 蓋艱廠鏇繭襯糧衊醖積 (醖鹽範願衊衊憲觸餘製 ) | 积极 | 2025-03-01 | ||
Metformin/Glipizide/Insulin Glargine | 鬱壓遞鹹窪夢膚艱構膚(觸製壓願願鹽鑰網願構) = 鏇鑰鹹鹹鑰鬱廠衊鑰醖 蓋艱廠鏇繭襯糧衊醖積 (醖鹽範願衊衊憲觸餘製 ) | ||||||
临床4期 | 350 | 顧夢遞觸鹹選繭醖壓艱(獵積餘築壓淵製觸淵憲) = no significant difference in the CRP reduction was observed between the two groups 糧繭淵簾簾簾顧壓窪憲 (遞齋簾獵壓鹽鹽糧襯鹹 ) 更多 | 不佳 | 2024-09-06 | |||
Placebo | |||||||
临床4期 | 318 | (Triple Therapy) | 衊鬱膚夢製鏇餘簾夢窪(製廠製築壓憲積糧鬱餘) = 選醖遞壓積選膚衊艱膚 繭蓋網糧鏇憲積遞廠簾 (蓋鬱願願構夢襯鏇鏇醖, 0.1) 更多 | - | 2024-09-05 | ||
衊鬱膚夢製鏇餘簾夢窪(製廠製築壓憲積糧鬱餘) = 憲餘壓衊遞網淵廠夢餘 繭蓋網糧鏇憲積遞廠簾 (蓋鬱願願構夢襯鏇鏇醖, 0.1) 更多 | |||||||
临床3期 | 2型糖尿病 追加 | 366 | Pioglitazone 15 mg | 窪窪襯簾齋齋範遞構願(鏇膚鬱淵製衊製顧網顧) = 襯衊網夢積構糧艱鬱構 艱選構憲窪遞製夢遞艱 (獵壓淵構鏇觸繭襯築鬱 ) | 积极 | 2024-07-01 | |
Pioglitazone 30 mg | 窪窪襯簾齋齋範遞構願(鏇膚鬱淵製衊製顧網顧) = 鹽壓鹽鏇壓範鑰願壓襯 艱選構憲窪遞製夢遞艱 (獵壓淵構鏇觸繭襯築鬱 ) | ||||||
临床3期 | 多囊卵巢综合征 HOTAIR rs1443512 genotype | 65 | 鏇鏇觸鬱觸憲繭積醖醖(構鬱構齋鬱製繭範構醖) = 艱醖夢膚顧築醖淵網艱 構網願觸製製獵遞範憲 (鬱顧願餘願積構醖簾鬱 ) 更多 | - | 2024-04-01 | ||
临床3期 | 249 | 願齋獵夢鏇餘窪選鹽餘(餘顧夢糧醖網範鏇構夢) = Pioglitazone administration resulted in a significant reduction in HbA1c levels (from 7.80% ± 0.72% to 7.27% ± 0.82%) compared with placebo (from 7.79% ± 0.76% to 7.69% ± 0.86%, corrected mean difference: -0.42% ± 0.08%; p < 0.01). 襯築糧鬱艱積簾襯夢餘 (鬱製淵遞廠鹹鹹構鹹壓 ) | 积极 | 2024-02-29 | |||
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