Tegafur/Uracil

Nasopharyngeal carcinoma (NPC) remains a challenging malignancy with high rates of recurrence following definitive therapy. This meta-analysis aimed to evaluate the efficacy of tegafur-uracil (UFT) maintenance therapy in patients with non-metastatic NPC after curative treatment. A systematic literature search of PubMed, Embase, and the Cochrane Library was performed to identify eligible studies. Three retrospective cohort studies including a total of 558 patients were analyzed. Random-effects meta-analysis demonstrated that UFT maintenance therapy significantly improved both progression-free survival [hazard ratio (HR)=0.53, 95% confidence interval (CI)=0.35-0.81] and overall survival (HR=0.37, 95%CI=0.21-0.65) compared to observation alone. Sensitivity analyses confirmed the robustness of these findings. However, trial sequential analysis indicated that the cumulative evidence did not meet the a priori information size required for a conclusive result, highlighting the need for further high-quality studies. In summary, UFT maintenance therapy may represent a promising option to reduce recurrence and improve survival in non-metastatic NPC, particularly in settings where access to novel agents is limited, but additional prospective studies are needed to confirm its clinical benefit.

We report a rare case of a solitary metastasis in which long-term complete remission was achieved with chemotherapy alone. An 81-year-old woman underwent a right hemicolectomy and D3 lymph node dissection for ascending colon cancer. Pathological findings showed type 2, 40×20 mm, tub2>muc, pT3, int, INF b, ly1, v0, pN1(1/32), pPM0, pDM0, and fStage Ⅲa. However, the patient chose not to undergo adjuvant chemotherapy and opted for further observation. Five months after the surgery, lymph node metastasis was observed near the right external iliac artery. Because the patient did not wish to undergo surgical treatment, SOX therapy was initiated. Owing to considerable side effects, the patient's treatment was switched to oral S-1. Gradually, the lesion disappeared, and the treatment was changed to UFT. The patient has maintained complete long-term remission for 10 years postoperatively. Here, we report this case along with a literature review.