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Ascletis pulls FXR agonist FXR agonist from pipeline over phase 2 primary biliary cholangitis data

2024-04-03

临床2期

Ascletis’ most advanced candidate is ASC22, an injected PD-L1 antibody in phase 2 development as a functional cure for chronic hepatitis B and HIV.

China’s Ascletis has been developing ASC22arnesoid X recPD-L1 antibodyonist ASC42 in a raft of conditions ranging from chronic hepatitis Blangitis (PBC) to metabolic-associated steatohepatitis (MASH).

But the company announced this morning that work is being halted on the drug after getting a glimpse of data from a phaprimary biliary cholangitis (PBC)es ometabolic-associated steatohepatitis (MASH)d that ASC42 did not show competitiveness to new PBC drug candidates currently in development and registrational stages,” the company explained in an April 4 release.

Based on this failure, Ascletis has also decided to drop other programs involving the drug. These include testing the therapy for hepatitis B virus (HBV) as wASC42s part of PBCombo treatment for MASH.ASC42 PBC

The biotech, which enteAscletisyear with cash and equivalents of 2.4 billion Chinese Yuan ($330 million), attributed today’s decision to “efforts to continue to evaluate and optimize its research and development pipeline to increase efficiency and preserve cash.”

With ASC42 thrown on the discard pile, Ascletis still has more promising options to treat MASH, a fatty liver disease that has previously been known as non-alcoholic steatohepatitis (NASH). At the start of the year, the company’s subsidiary Gannex Pharma linked a THRβ agonist, dubbed ASC41, to significant reductions in liver fat and pointed to findings that it sees providing an edge over Madrigal Pharmaceuticals and Viking Therapeutics.

Viking has previously accused Ascletis of stealing trade secrets to support the developmenMASH a dfatty liver diseaseval its MASH prospect VK2809. That non-alcoholic steatohepatitis (NASH)ear, during which time Gannex continued to work towarGannex Pharmata on the THRβcule at the centeASC41the row.Madrigal Pharmaceuticals Viking Therapeutics

Ascletis’ most advanced candidAscletisSC22, an injected PD-L1-targeted antibody in phase 2 development as a functional cure for chronic hepVK2809 B and HIV. The company's clinical-stage pipeline also includes a Gannexnhibitor called ASC40 that’s being assessed as a treatment for both MASH and acne, as well as a PD-L1 small molecule inhibitor called ASC61 in early-stage trials for solid tumors.

Part of the savings from discontinuing the various ASC42PD-L1-targeted antibody PD-L1-targeted be funneled into the continued clinical development of ASchronic hepatitis BASH, the biotech explained in today’s release.FASN inhibitor FASN ASC40 MASH acne PD-L1 inhibitor solid tumors

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