别名 DER4、FIT-1、homolog of mouse growth stimulation-expressed + [10] |
简介 Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (PubMed:16286016) (Probable). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity).
Inhibits IL-33 signaling. |
靶点 |
作用机制 IL-33R抑制剂 |
在研机构 |
原研机构 |
在研适应症 |
最高研发阶段临床3期 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
靶点 |
作用机制 IL-33R抑制剂 |
在研机构 |
原研机构 |
非在研适应症- |
最高研发阶段临床1/2期 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
靶点 |
作用机制 IL-33R调节剂 [+2] |
最高研发阶段临床1/2期 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
开始日期2024-11-01 |
申办/合作机构- |
开始日期2024-06-17 |
申办/合作机构 |
开始日期2023-12-14 |
申办/合作机构 Roche Holding AG [+1] |