别名 c-ros oncogene 1 , receptor tyrosine kinase、c-Ros receptor tyrosine kinase、c-ros-1 + [10] |
简介 Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. |
作用机制 ALK抑制剂 [+3] |
在研适应症 |
非在研适应症 |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期2023-11-15 |
作用机制 ALK抑制剂 [+1] |
原研机构 |
在研适应症 |
非在研适应症 |
最高研发阶段批准上市 |
首次获批国家/地区 中国 |
首次获批日期2023-06-27 |
作用机制 ALK抑制剂 [+2] |
在研机构 |
原研机构 |
在研适应症 |
最高研发阶段批准上市 |
首次获批国家/地区 中国 |
首次获批日期2020-11-17 |
开始日期2024-09-01 |
申办/合作机构 |
开始日期2024-08-01 |
申办/合作机构 |
开始日期2024-06-01 |
申办/合作机构 Cancer Research UK [+4] |