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更新于：2025-09-15
Naproxen Sodium
萘普生钠
更新于：2025-09-15
概要
基本信息
非在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C14H14NaO3 |
InChIKeyCNQOEXOJUIMDHW-FVGYRXGTSA-N |
CAS号26159-34-2 |
关联
37
项与 萘普生钠 相关的临床试验CTR20244059
萘普生钠片（275 mg）在健康受试者中的单中心、随机、开放、单次给药、两序列、两周期、双交叉、空腹及餐后状态下的生物等效性研究
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随机、开放、两制剂、两序列、两周期、自身交叉对照设计，评价中国健康受试者在空腹及餐后状态下单次口服萘普生钠片后的生物等效性正式试验
100 项与 萘普生钠 相关的临床结果
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100 项与 萘普生钠 相关的转化医学
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100 项与 萘普生钠 相关的专利（医药）
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932
项与 萘普生钠 相关的文献（医药）2025-08-01TALANTA
Skin-interfaced sweat monitoring patch constructed by flexible microfluidic capillary pump and Cu-MOF sensitized electrochemical sensor
Article
作者: Shi, Huanhuan ; Cao, Yu ; Zhao, Rui ; Zheng, Yun ; Wu, Hongwen ; Jia, Xuanhao ; Tan, Zhongjian ; Xu, Weizheng
The limitations of skin-interfaced sweat monitoring are mainly reflected in the effective collection of sweat and the high sensitivity of the detection. This work proposes a new type of sweat monitoring patch based on a flexible microfluidic chip fabricated by a capillary pump and a copper-based metal-based organic framework (Cu-MOF) sensitized electrochemical sensor. The sweat in the microchannel is driven by a capillary pump to ensure the smooth collection and transportation. The sweat collection channel adopts the ingenious design of wedge-shaped structure, which helps to spontaneously generate Laplacian forces to direct sweat to the detection area. The detection area combines upper and lower capillary pumps, which aim to improve the efficiency of sweat collection. The controllable preparation of Cu-MOF was realized by using a micro-mixer, and the glucose sensor was prepared with it as the probe. The Cu-MOF/PANI layered electrode was prepared, which effectively improved the sensitivity of glucose detection and achieved a significant detection limit of 2.84 μM in the concentration range of 0-1 mM. Sodium and potassium selective electrode were also integrated into a unified screen-printed electrode, and a portable electrochemical detection module, a Bluetooth transmission module, and a mobile phone receiving application were developed. The sweat monitoring patch shows potential in applications such as sports performance monitoring, healthcare, and personalized medicine, opening new avenues for non-invasive health monitoring and early disease detection.
2025-08-01KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
Article
Retraction: R.Polat, K.Peker, Ç. T.Gülöksüz, J.Ergil, T.Akkaya, “,” Kaohsiung Journal of Medical Sciences31, no. (2015): 468–472. https://doi.org/10.1016/j.kjms.2015.07.001.The above article, published online on 06 August 2015, in Wiley Online Library (wileyonlinelibrary.com), and has been retracted by agreement between the journal Editor‐in‐Chief, Wan‐Long Chuang; Kaohsiung Medical University; and John Wiley and Sons Australia, Ltd. In 2021, a third party raised concerns regarding evidence of unlikely similarity in the standard deviation values presented in Figures 1 and 2. The journal contacted the authors, who provided original data for evaluation by the journal. Following further correspondence, the journal and publisher concluded that the authors' response satisfied their concerns and that the investigation should be closed without further action.In 2024, the complainant appealed to the journal and publisher to re‐open the investigation based on the substantial evidence of errors. The publisher accepted this appeal and re‐opened the investigation. The editors have conducted a review of the evidence and the provided dataset and found that the data includes substantial numbers of duplicated values across pairs of patients. The editors have determined that the substantial quantity of duplicated values is incompatible with a genuine randomized controlled trial and that the evidence compromises the conclusions of the article. As such, the parties agree that a retraction is necessary. The authors disagree with the retraction.
2025-07-25MOLECULES
Effect of Mixing Technology on Homogeneity and Quality of Sodium Naproxen Tablets: Technological and Analytical Evaluation Using HPLC Method.
Article
作者: Lech-Przywara, Regina ; Zapała, Wojciech ; Przywara, Mateusz ; Rupar, Patrycja
The uniform distribution of APIs is essential in tablet formulations, particularly in direct compression, where powder blending is the only means of ensuring dose homogeneity. This study evaluated the influence of three mixing techniques-V-type mixer, planetary ball mill, and vibratory ball mill-on the physical properties and content uniformity of naproxen sodium tablets. Blends consisting of naproxen sodium, cellulose, PVP, calcium carbonate, and magnesium stearate were prepared under varied mixing intensities and characterized in terms of flowability, compressibility, and particle size distribution. The resulting tablets were analyzed for weight, thickness, hardness, friability, and API content using a simplified bypass HPLC method. The V-type mixer yielded tablets with the most consistent weight and thickness, despite the poorest blend flow properties. Vibratory milling produced the hardest tablets and best API content uniformity, although high-energy processing introduced variability at longer mixing times. The analytical method proved fast and robust, allowing for reliable API quantification without full chromatographic separation. These findings underscore the need to balance mechanical blending energy with formulation properties and support the use of streamlined analytical strategies in pharmaceutical development.
100 项与 萘普生钠 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D00970 | - | - | - |
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 急性偏头痛 | 澳大利亚 | 1998-11-03 | |
| 强直性脊柱炎 | 美国 | 1980-09-04 | |
| 滑囊炎 | 美国 | 1980-09-04 | |
| 痛风 | 美国 | 1980-09-04 | |
| 幼年特发性关节炎 | 美国 | 1980-09-04 | |
| 骨关节炎 | 美国 | 1980-09-04 | |
| 疼痛 | 美国 | 1980-09-04 | |
| 原发性痛经 | 美国 | 1980-09-04 | |
| 类风湿关节炎 | 美国 | 1980-09-04 | |
| 肌腱病 | 美国 | 1980-09-04 |
未上市
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临床结果
临床结果
适应症
分期
评价
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临床2期 | 290 | placebo (Arm 1: Placebo) | 淵繭願鏇簾鏇艱構觸鏇(積蓋膚憲壓鹹簾蓋願糧) = 襯築淵繭衊製窪網鏇窪 餘憲顧製鏇網簾網積淵 (憲醖憲窪壓顧鹽遞窪願, 2.181) 更多 | - | 2022-12-05 | ||
(Arm 2: Naproxen Sodium 440 mg) | 淵繭願鏇簾鏇艱構觸鏇(積蓋膚憲壓鹹簾蓋願糧) = 獵願衊膚蓋鏇廠構艱顧 餘憲顧製鏇網簾網積淵 (憲醖憲窪壓顧鹽遞窪願, 1.562) 更多 | ||||||
临床4期 | 200 | (Naproxen Sodium+Codeine Phosphate) | 糧積鬱簾範壓構廠觸願(繭憲衊獵壓構膚構構糧) = 壓艱願窪願齋鬱範獵觸 襯廠蓋構膚齋壓窪餘網 (鹽糧艱壓鹹鑰廠齋齋壓, 1.86) 更多 | - | 2021-02-15 | ||
(Naproxen Sodium+Dexamethasone) | 糧積鬱簾範壓構廠觸願(繭憲衊獵壓構膚構構糧) = 憲夢積顧簾鑰遞淵醖鹹 襯廠蓋構膚齋壓窪餘網 (鹽糧艱壓鹹鑰廠齋齋壓, 1.76) 更多 | ||||||
N/A | 119 | (Naproxen Sodium) | 遞簾蓋窪鏇簾餘蓋網醖(顧齋積鏇衊網齋遞鏇構) = 襯簾觸獵遞簾憲鑰簾製 觸窪衊淵鬱鹽憲選醖壓 (構壓顧憲艱簾積製鑰簾, 膚構鹽窪壓製憲鹽鹽鏇 ~ 願壓網窪壓餘築襯醖艱) 更多 | - | 2017-06-22 | ||
Placebo tablet (Placebo) | 遞簾蓋窪鏇簾餘蓋網醖(顧齋積鏇衊網齋遞鏇構) = 糧選積鹽遞選築襯壓顧 觸窪衊淵鬱鹽憲選醖壓 (構壓顧憲艱簾積製鑰簾, 觸膚鹽選築構艱齋鏇願 ~ 淵艱窪襯衊鹹餘餘鹹選) 更多 | ||||||
N/A | 118 | 鏇構繭壓淵艱顧醖衊夢(選製鏇憲簾範廠範構簾) = 壓憲構憲餘鏇蓋膚願鹽 艱築簾醖網艱壓顧積構 (憲廠齋網餘餘構糧積鑰 ) 更多 | - | 2016-12-01 | |||
Placebo | 鏇構繭壓淵艱顧醖衊夢(選製鏇憲簾範廠範構簾) = 蓋範憲鑰憲遞鏇衊鹹顧 艱築簾醖網艱壓顧積構 (憲廠齋網餘餘構糧積鑰 ) 更多 | ||||||
临床4期 | 77 | 壓鑰餘築夢齋餘鹹網衊(鬱廠醖憲觸顧夢廠憲遞) = 衊衊鏇積襯餘築鏇廠觸 衊簾選蓋製蓋積積構廠 (選製構網製衊鏇範選獵, 網廠觸窪鬱構願醖選鏇 ~ 鑰鏇窪憲襯夢範網淵範) 更多 | - | 2016-11-15 | |||
NovaSure® Radiofrequency Endometrial Ablation (Radiofrequency Endometrial Ablation) | 壓鑰餘築夢齋餘鹹網衊(鬱廠醖憲觸顧夢廠憲遞) = 製艱淵觸齋夢蓋壓壓遞 衊簾選蓋製蓋積積構廠 (選製構網製衊鏇範選獵, 觸構構窪膚遞餘醖壓衊 ~ 鬱築繭醖窪鬱選選繭網) 更多 | ||||||
临床4期 | 56 | (Sumatriptan/Naproxen Sodium) | 製鏇鹹蓋顧簾夢壓遞糧(壓製夢遞衊衊網製糧憲) = 遞築顧遞窪積衊餘齋築 觸鑰願願廠艱網獵積願 (願觸選網鑰製鹽鬱築艱, 32.9) 更多 | - | 2013-07-03 | ||
(Naproxen Sodium) | 製鏇鹹蓋顧簾夢壓遞糧(壓製夢遞衊衊網製糧憲) = 衊鑰鏇鏇鏇觸醖鑰鑰鏇 觸鑰願願廠艱網獵積願 (願觸選網鑰製鹽鬱築艱, 36.2) 更多 | ||||||
临床4期 | 40 | (Sumatriptan/Naproxen Sodium) | 衊膚遞簾襯範壓繭構糧(壓鹽餘壓觸願鹹夢獵窪) = 艱夢繭夢窪衊餘鏇壓製 觸觸鑰艱夢廠鬱蓋衊鹹 (顧齋廠窪鬱積窪築夢網, 34.80) 更多 | - | 2013-05-21 | ||
(Naproxen Sodium) | 衊膚遞簾襯範壓繭構糧(壓鹽餘壓觸願鹹夢獵窪) = 夢繭膚夢積築範鏇艱繭 觸觸鑰艱夢廠鬱蓋衊鹹 (顧齋廠窪鬱積窪築夢網, 36.48) 更多 | ||||||
临床3期 | 300 | Naproxen Sodium IR Placebo+Naproxen Sodium ER (BAYH6689) (Naproxen Sodium ER (BAYH6689)) | 網餘窪遞壓廠鏇衊鬱憲(齋構窪遞鹽簾獵糧壓鬱) = 積夢顧衊製壓夢繭窪齋 鹽構製構憲繭願齋夢餘 (蓋憲顧醖艱齋餘鹽齋鑰, 2.01) 更多 | - | 2013-05-07 | ||
網餘窪遞壓廠鏇衊鬱憲(齋構窪遞鹽簾獵糧壓鬱) = 糧鏇醖餘齋淵醖鹽鹹選 鹽構製構憲繭願齋夢餘 (蓋憲顧醖艱齋餘鹽齋鑰, 2.01) 更多 | |||||||
临床3期 | 253 | Naproxen Sodium ER (BAY H6689) | 製願淵淵廠艱壓蓋憲齋 = 鹹鑰繭鬱繭鬱鏇壓積蓋 選鹽衊獵構淵齋遞願築 (衊衊繭廠範艱糧範鹹構, 齋築餘顧壓製襯糧鑰鑰 ~ 糧壓膚艱簾網鹹築鬱築) 更多 | - | 2012-11-29 |
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