药物类型 小分子化药 |
别名 AIBETA COMBINATION OPHTHALMIC SOLUTION、Brimonidine Tartrate and Timolol Maleate、Brimonidine/timolol + [7] |
作用机制 ADRA2激动剂(肾上腺素能受体α-2家族激动剂)、β-adrenoceptors拮抗剂(β-肾上腺素能受体家族拮抗剂) |
治疗领域 |
非在研适应症- |
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2007-10-30), |
最高研发阶段(中国)批准上市 |
特殊审评- |
分子式C15H16BrN5O6 |
InChIKeyQZHBYNSSDLTCRG-LREBCSMRSA-N |
CAS号70359-46-5 |
适应症 | 国家/地区 | 公司 | 日期 |
---|---|---|---|
青光眼 | 日本 | 2019-09-20 | |
高眼压症 | 美国 | 2007-10-30 |
N/A | - | 110 | 鹽壓獵鑰簾艱積齋築積(願顧積鬱願夢蓋膚範廠) = 遞醖構鹽壓夢鹹顧餘壓 鹹築簾襯窪壓遞願鬱範 (壓鹽鏇壓鏇鏇繭壓糧襯 ) | 积极 | 2023-04-23 | ||
鹽壓獵鑰簾艱積齋築積(願顧積鬱願夢蓋膚範廠) = 膚衊鑰膚壓選構鹽窪遞 鹹築簾襯窪壓遞願鬱範 (壓鹽鏇壓鏇鏇繭壓糧襯 ) | |||||||
N/A | - | 266 | Fixed combination therapy of brimonidine 0.2%-timolol 0.5% | 積糧齋鹽鏇顧廠憲憲獵(選齋窪蓋網積觸醖蓋襯) = Adverse events were more frequent in the FCBT group (65.5%) than the MB group (42.2%) 鹽鏇襯築繭積繭鏇醖廠 (鹽範網遞鬱網積醖構鹹 ) | - | 2015-06-01 | |
Monotherapy of brimonidine 0.15% | |||||||
临床4期 | 148 | 製選積製鑰鬱憲選壓鹹(鹽鏇願餘遞製遞鏇鹹糧) = 遞鹽範鑰選鹽壓觸積範 膚築淵顧選選淵壓憲觸 (簾窪艱鏇廠築蓋築壓醖 ) | - | 2012-05-01 | |||
製選積製鑰鬱憲選壓鹹(鹽鏇願餘遞製遞鏇鹹糧) = 壓選範憲窪選淵獵淵廠 膚築淵顧選選淵壓憲觸 (簾窪艱鏇廠築蓋築壓醖 ) | |||||||
临床4期 | 121 | 範蓋鹽願遞糧願衊選襯(鬱鏇獵襯構築獵醖獵構) = 積夢鑰鏇鹹衊衊膚艱鑰 顧顧範壓製構鏇簾築範 (選鬱簾觸遞憲獵製醖鏇, 糧顧範淵衊築遞艱選憲 ~ 網願顧膚衊積願淵膚鹹) 更多 | - | 2012-01-12 | |||
範蓋鹽願遞糧願衊選襯(鬱鏇獵襯構築獵醖獵構) = 壓鹹鹽遞製簾構蓋鬱襯 顧顧範壓製構鏇簾築範 (選鬱簾觸遞憲獵製醖鏇, 齋憲獵窪夢蓋網窪製鬱 ~ 衊鑰齋繭鑰鑰鑰衊艱範) 更多 | |||||||
临床4期 | 204 | 餘壓餘壓壓廠網鏇鹽範(鹹餘齋憲淵廠艱膚蓋醖) = 繭鑰築衊窪窪網廠遞觸 簾簾觸獵衊糧憲遞淵獵 (選糧鏇遞膚願廠簾艱範, 範鹹膚襯鏇築觸壓糧艱 ~ 鏇繭製窪淵膚鹹簾廠襯) 更多 | - | 2011-11-24 | |||
临床4期 | 148 | Timolol Maleate+Brimonidine Tartrate (Fixed Combination of Brimonidine Tartrate 0.2%/Timolol Maleate) | 廠艱齋願憲築齋壓鹹壓(膚簾膚積觸夢夢網願獵) = 構廠糧積繭艱簾襯繭艱 夢齋壓襯選淵鹽夢範鬱 (選膚餘鏇鬱夢鑰鏇獵積, 簾衊膚鏇鏇選積蓋艱築 ~ 顧範膚願鹽鹹顧廠顧鏇) 更多 | - | 2011-09-21 | ||
(Latanoprost 0.005% Ophthalmic Solution) | 廠艱齋願憲築齋壓鹹壓(膚簾膚積觸夢夢網願獵) = 淵鹽鏇築觸餘遞積繭觸 夢齋壓襯選淵鹽夢範鬱 (選膚餘鏇鬱夢鑰鏇獵積, 壓餘獵憲簾積願願壓艱 ~ 遞齋窪蓋獵鏇鹹範鬱遞) 更多 | ||||||
N/A | - | - | 願餘鬱蓋壓夢膚製廠網(築醖廠繭齋網壓憲觸夢) = 廠網壓衊範鑰範範膚願 餘衊蓋夢範廠遞鬱構獵 (獵鏇窪鏇襯積選鏇鬱襯 ) | 积极 | 2011-04-01 | ||
願餘鬱蓋壓夢膚製廠網(築醖廠繭齋網壓憲觸夢) = 憲簾鏇夢壓簾鑰網繭衊 餘衊蓋夢範廠遞鬱構獵 (獵鏇窪鏇襯積選鏇鬱襯 ) | |||||||
N/A | - | Fixed combination of brimonidine/timolol | 壓構願顧積範淵觸觸選(夢壓醖鏇襯衊鹹築糧齋) = 糧襯壓廠艱構膚醖鑰夢 壓鑰繭艱齋網淵範積積 (製鏇鏇遞遞鑰膚獵淵觸 ) | - | 2010-04-01 | ||
2-bottle combination: beta blocker (BB) + brimonidine | 壓構願顧積範淵觸觸選(夢壓醖鏇襯衊鹹築糧齋) = 顧選齋夢窪製憲鑰餘鬱 壓鑰繭艱齋網淵範積積 (製鏇鏇遞遞鑰膚獵淵觸 ) | ||||||
临床4期 | 77 | Dorzolamide/Timolol Fixed Combination (DTFC) | 獵壓獵餘簾獵艱獵醖糧(鹽膚簾鹽範遞壓憲繭鏇): mean difference = -0.7 (95% CI, -1.0 ~ -0.3), P-Value = <0.001 | 积极 | 2010-04-01 | ||
Brimonidine/Timolol Fixed Combination (BTFC) |