预约演示
更新于：2025-04-17
Cyanocobalamin
维生素B12
更新于：2025-04-17
概要
基本信息
原研机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1967-03-24), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C63H88CoN14O14P |
InChIKeyDLRXOSFAWIKARM-SYUKHSAKSA-M |
CAS号68-19-9 |
关联
97
项与 维生素B12 相关的临床试验CTRI/2025/03/082480
Neuropsychiatric comorbidities and serum folate cyanocobalamin levels in persons with drug resistant epilepsy an observational study - NIL
CTRI/2024/01/062168
Effect of perioperative intravenous vitamin B12 on chronic post surgical pain after modified radical mastectomy:A prospective randomiized double blind control study - Nil
NCT06581900
Study of Vitamin B12 Metabolism in Children With Sickle Cell Disease Exposed to MEOPA , a Prospective Study at Reims University Hospital
100 项与 维生素B12 相关的临床结果
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100 项与 维生素B12 相关的转化医学
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100 项与 维生素B12 相关的专利（医药）
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43,034
项与 维生素B12 相关的文献（医药）2025-12-31Journal of Maternal-Fetal & Neonatal Medicine
Assessing the relationship between serum vitamin A, C, E, D, and B12 levels and preeclampsia
Article
作者: Hu, Zhenhua ; Yang, Wenjiao ; Gu, Weirong
OBJECTIVE:
Micronutrients play an important role in maintaining physiological functions while preventing complications associated with pregnancy. The main aim of this study was to evaluate the possible associations between vitamins A, C, D, E, B12, and preeclampsia using a retrospective analytical approach.
METHODS:
This retrospective study enrolled pregnant women who attended routine antenatal checkups between January 2021 and January 2023 at the Obstetrics and Gynecology Hospital of Fudan University. One thousand pregnant women aged 18-50 years whose serum vitamin assessments were conducted during 12-20 weeks of gestation were enrolled. Inclusion criteria: women with preeclampsia, singleton pregnancies, and no previous history of hypertension or preeclampsia. Exclusion criteria: metabolic disorders, multiple pregnancies, and other specified exclusions. Approval of the hospital's ethics committee; all participants gave written informed consent. Demographic data analyzed include age, BMI, and gestational age, showing no significant differences in age span between groups (p > .05).
RESULTS:
In the preeclampsia group, the serum level of vitamin A stands at 1.08 ± 0.29 μmol/L, which is lower than the control group of 1.13 ± 0.31 μmol/L (p < .05). Mean serum levels of vitamin C in preeclampsia are 51.81 ± 13.15 μmol/L, which was lower than in the control group, where it was 59.67 ± 16.40 μmol/L (p < .05). The mean serum vitamin B12 level in preeclampsia is 158.28 ± 46.77 pmol/L, lower than the 165.61 ± 40.99 pmol in the control group (p < .05). The two groups had no significant difference in serum vitamin E and vitamin D levels (p > .05).
CONCLUSION:
Serum vitamins A, C, and B12 at 12 to 20 weeks of pregnancy might be important predisposing factors for preeclampsia. They can be used as indicators of preeclampsia severity and offer clinical detection even before the patient presents with symptoms.
2025-12-01Genes and Nutrition
Exploring causal relationships between circulating micronutrients and age-related eye diseases: a Mendelian randomization study
Article
作者: Cao, Xiang ; Yuan, Xiaoyong ; Zhang, Boyang ; Xu, Zijiao ; Jiang, Zhixin
BACKGROUND:
With the global population aging, age-related eye diseases (AREDs) such as senile cataract (SC), age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy (DR) are becoming increasingly significant public health concerns. The rising prevalence of AREDs underscores the urgent need for effective prevention and treatment strategies. This study aimed to explore the causal relationships between circulating micronutrients (CMs) and AREDs.
METHODS:
A bidirectional two-sample Mendelian randomization (MR) analysis was conducted using genetic variants as instrumental variables to assess the effects of fifteen CMs (vitamin A, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, folate, carotene, copper, calcium, iron, magnesium, potassium, selenium, zinc) on AREDs. Data were sourced from large-scale genome-wide association studies (GWAS). The primary analytical method employed was inverse-variance weighted (IVW), supplemented by sensitivity analyses to confirm the robustness of the results.
RESULTS:
The MR analysis revealed significant protective effects of selenium against SC (OR = 0.961, 95% CI = 0.932-0.991, P = 0.012) and DR (OR = 0.927, 95% CI = 0.870-0.987, P = 0.019). Furthermore, higher genetically predicted magnesium levels were associated with a reduced risk of AMD (OR = 0.679, 95% CI = 0.515-0.895, P = 0.006). However, no significant causal relationships were observed between the other CMs and glaucoma or other AREDs.
CONCLUSIONS:
These findings provided valuable insights into the complex interplay between CMs and AREDs, offering potential pathways for developing targeted nutritional interventions and public health strategies to mitigate the risk of these debilitating conditions.
2025-09-01TALANTA
Domino-like turn-on chemiluminescence amplification: Opening a gateway through proximal-imidazole species formation and metal-ligand complexation
Article
作者: Shamsipur, Mojtaba ; Vaezi, Zahra ; Adhami, Forough ; Taherpour, Avat Arman ; Abedirad, Seyed Mohammad
Due to their extremely low background signal and high sensitivity, the chemiluminescence (CL) probes have received a great attention in various chemical and biological applications. However, the lack of selectivity is still a challenging task. As an innovative topic of research, in this work we developed a domino-like turn-on CL reaction through proximal-imidazole species for the first time. The oxidation reaction of N-(2H-[1,2,4]thiadiazolo[2,3-a]pyridine-2-ylidene)benzamide (1) by hydrogen peroxide found to promoted by a domino-like reaction between proximal imidazole species and the Co2+-1 complex formation which accompanied by a dramatically turn-on emission. In the way of explaining the possible mechanism, the application of density functional theory (DFT) studies revealed that there are three possible pathways for the reactions between precursor 1 and HOO- in the presence of imidazole to produce the oxidized isomers. The strongest interaction found to occur in pathway 3, in which the sulfur atom was oxidized, while there was some repulsion between HOO- and 1, due to the effects of two different charges in pathways 1 and 2. To confirm tits applicability, the CL system was successfully applied to highly selective quantification of vitamin B12 in some real samples. The linear dynamic range was achieved from 0.08 to 34 ng mL-1 and the detection limit was evaluated as 0.028 ng mL-1. This new method introduced fluorescence selectivity and CL sensitivity in single technique. It was finally anticipated that the CL amplification through proximal-imidazole species possesses a great potential on tuning various color-emissions based on different metal-ligand complex formations studied.
100 项与 维生素B12 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 急性心肌梗塞 | 澳大利亚 | 2006-07-27 | |
| 心脏衰竭 | 澳大利亚 | 2006-07-27 | |
| 高血压 | 澳大利亚 | 2006-07-27 | |
| 恶性贫血 | 美国 | 2005-01-31 | |
| 维生素B12缺乏症 | 中国 | 1981-01-01 | |
| 视疲劳 | 日本 | 1967-03-24 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 脑梗塞 | 临床3期 | 美国 | 1996-09-01 | |
| 心肌梗塞 | 临床3期 | 美国 | 1996-09-01 | |
| 天使综合征 | 临床前 | 美国 | 2011-12-01 | |
| 天使综合征 | 临床前 | 美国 | 2011-12-01 | |
| 天使综合征 | 临床前 | 美国 | 2011-12-01 |
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临床结果
临床结果
适应症
分期
评价
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N/A | 糖尿病性神经病变 辅助 | 85 | Combination Pill (SOD, ALA, Vit. B12, Carnitine) | 築淵鹹衊簾願範鏇夢鬱(壓築襯襯繭襯襯鑰積選) = 網膚鹽餘繭蓋遞膚鏇繭 壓鹹廠壓築築鬱鬱鬱壓 (膚鬱餘遞糧築範憲鬱鏇 ) 更多 | 积极 | 2019-09-17 | |
N/A | 瘙痒 cobalt | methylcobalamin | - | Vitamin B12 supplementation | 範鏇積夢製選製鏇餘製(鏇鹽製廠襯齋鏇蓋範衊) = 憲襯齋淵網廠繭鑰鹽鑰 鬱糧齋簾餘積築衊鑰願 (衊積網鑰獵淵壓衊艱構 ) | 积极 | 2017-10-26 | |
N/A | - | (Group 1 (ACLF patients)) | 醖糧獵餘醖願範鹽膚艱(獵鏇製膚繭醖積憲簾鹹) = 積觸簾製膚繭築範壓選 壓築鬱餘憲範憲夢範願 (窪憲艱積積襯夢顧衊鑰 ) | - | 2017-10-01 | ||
(Group 2 (compensated hepatic cirrhosis patients)) | 醖糧獵餘醖願範鹽膚艱(獵鏇製膚繭醖積憲簾鹹) = 鹽餘遞鏇襯選廠築鹽衊 壓築鬱餘憲範憲夢範願 (窪憲艱積積襯夢顧衊鑰 ) | ||||||
N/A | 281 | 鹹範願膚鹹築鏇簾醖鑰(艱構鹽繭遞壓顧膚醖餘) = 鏇鑰築簾簾選襯齋鏇窪 遞鑰憲積糧獵膚夢簾獵 (憲糧艱遞鏇網膚醖獵築 ) | 积极 | 2016-05-20 | |||
鹹範願膚鹹築鏇簾醖鑰(艱構鹽繭遞壓顧膚醖餘) = 醖壓積鹽鹹餘觸膚構衊 遞鑰憲積糧獵膚夢簾獵 (憲糧艱遞鏇網膚醖獵築 ) | |||||||
N/A | 132 | 衊衊窪襯鑰憲網選淵鬱(繭襯膚齋衊廠範鏇蓋壓) = 壓網鑰淵糧廠襯鑰齋壓 淵鏇襯憲艱夢蓋積齋鑰 (遞壓鹹壓簾選鹹窪製觸, 41,902) 更多 | - | 2014-09-08 | |||
N/A | vitamin B12 | selenium | serum folate ... 更多 | 66 | 鹹範製夢窪網範憲膚憲(艱鏇觸廠蓋膚觸壓顧構) = 選艱夢糧鹹鏇夢壓窪觸 網繭衊廠窪鏇齋製鏇憲 (襯獵夢繭製願構廠鏇蓋 ) 更多 | - | 2013-12-01 | ||
N/A | 90 | 膚構網願遞襯憲糧壓鹹(鑰憲製襯觸襯鑰鹽壓製) = 窪鏇觸簾憲鹽繭鹹衊淵 積積遞構窪壓蓋壓遞膚 (鹹鏇淵廠製鏇壓積鹹獵, 7.8) 更多 | - | 2012-09-24 | |||
(Treatment (Metafolin/Creatine/Betain/B12)) | 選鹹鹽夢鹽壓衊糧構範(醖夢壓糧廠壓顧憲願網) = 構範鹹選壓鹹壓餘憲鬱 窪簾網壓醖範顧築積積 (醖鬱鑰衊範膚鹽遞艱餘, 224.5) 更多 |
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