预约演示
更新于：2025-10-28
Cyanocobalamin
维生素B12
更新于：2025-10-28
概要
基本信息
原研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1967-03-24), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C63H88CoN14O14P |
InChIKeyDLRXOSFAWIKARM-SYUKHSAKSA-M |
CAS号68-19-9 |
关联
173
项与 维生素B12 相关的临床试验NCT06966856
Sublingual Versus Oral Vitamin B12 for Acute Hypovitaminosis B12 Secondary to Proton Pump Inhibitors: A Prospective Randomized Study
ChiCTR2500110037
A Single-Center, Randomized, Superiority Phase II Clinical Study of Intrathecal Pemetrexed Chemotherapy with Concurrent Radiotherapy Followed by Long-Term Intrathecal Maintenance therapy in Patients with Refractory Leptomeningeal Metastases from Non-Small Cell Lung Cancer
CTRI/2025/06/088909
Comparing the efficacy of oral versus injectable vitaminB12 in patients with Neurocutaneous Infantile VitaminB12 deficiency Syndrome (NIBS): A RandomizedControlled Trial - NIL
100 项与 维生素B12 相关的临床结果
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100 项与 维生素B12 相关的转化医学
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100 项与 维生素B12 相关的专利（医药）
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31,924
项与 维生素B12 相关的文献（医药）2026-02-01NUTRITION
Validation of a self-administered web-based 24-h dietary recall for individuals with severe obesity undergoing bariatric surgery
Article
作者: Morisset, Anne-Sophie ; Leblanc, Vicky ; Lemieux, Simone ; Laramée, Catherine ; Legault, Marianne ; Lachance, Amélie ; Michaud, Andréanne ; Pelletier, Mélissa ; Ross, Sarah-Kim ; Lamarche, Benoît ; Biertho, Laurent ; Harrison, Stéphanie
AIM:
The study aimed to assess the validity of a web-based 24-h recall (R24W) for measuring dietary intakes in individuals living with severe obesity who are awaiting bariatric surgery, compared to a food record (FR), currently used in clinical settings.
METHODS:
A total of 51 individuals with severe obesity awaiting bariatric surgery were recruited (mean age: 45.3 ± 8.0 years). Before surgery, participants completed three R24W and a 3-day FR. Nutritional intakes were derived from the 2015 version of the Canadian Nutrient File. Mean differences in energy and nutrient intakes were assessed using percent differences and paired t-tests. Spearman correlations evaluated the associations between tools, while cross-classification analyses, weighted kappa scores, and Bland-Altman analyses were used to assess the degree of agreement. To determine validity, a seven-criterion validity analysis proposed by Lombard et al. was applied. The R24W was considered valid if it had three or fewer poor scores.
RESULTS:
Energy, carbohydrates, proteins, fats, saturated fat, dietary fiber, vitamin B6, vitamin B12, vitamin C, vitamin D, calcium, iron, magnesium, potassium, and sodium had three or fewer poor scores, suggesting that the R24W provides an estimation of these nutrient intakes similar to the FR. In contrast, vitamin A, riboflavin, thiamin, folate, niacin, and phosphorus scored below the threshold of poor scores.
CONCLUSION:
The R24W demonstrated good validity for assessing energy intake, macronutrients, and several key nutrients (e.g., iron and vitamin D) in this population. These findings support the use of the R24W as a clinical and valid tool for dietary assessment in the bariatric population.
2026-01-01CLINICA CHIMICA ACTA
Ethnicity-based variations in biological reference interval- A systematic scoping review
Article
作者: Chatterjee, Nabendu Sekhar ; Makhija, Ishika ; Bansal, Savita ; Maurya, Saanvi ; Chandra, Nilesh ; Sivakumar, Sasidharan ; Bhagat, Ruchika
BACKGROUND:
Biological reference intervals (RIs) are fundamental tools in clinical diagnostics, traditionally derived from geographically and ethnically homogeneous populations, predominantly of Western origin. Such generalized RIs often fail to account for variations arising from genetic, environmental, and lifestyle factors, which can impact clinical decision-making and contribute to health inequities, particularly in countries across Africa, India, and many other Southeast Asian nations. This scoping review investigates ethnicity-based variations in RIs for a range of biomarkers to highlight the importance of population-specific RIs.
METHODS:
Adhering to the Joanna Briggs Institute (JBI) guidelines, this scoping review examined the literature on ethnicity-based RI variations across multiple biomarkers, including Von Willebrand factor, C-reactive protein, thyroid-stimulating hormone, albumin, creatinine, and more. Studies were identified via searches in MEDLINE (via PubMed), Embase, Scopus, and Web of Science up to December 30, 2024. Eligibility was determined using the Population-Concept-Context (PCC) framework, focusing on observational studies analysing ethnicity-specific differences. Data extraction and charting were performed using CADIMA software, with independent review by two authors to ensure consistency.
RESULTS:
Out of 4,514 articles, a total of 15 studies met the inclusion criteria, encompassing multi-ethnic populations. Significant variations in biomarker levels were observed across ethnic groups, highlighting the inadequacy of generalized RIs. Notable differences included variations in lipid profiles, vitamin B12, and anti-Mullerian hormone levels. Regional distribution analysis highlighted gaps in research from underrepresented ethnic populations.
CONCLUSION:
This review emphasizes the critical need for ethnicity-specific RIs to improve diagnostic accuracy and promote equitable healthcare outcomes. Further research should focus on developing robust methodologies for establishing inclusive and representative RIs.
2026-01-01JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Investigating the relationship between dietary vitamin B12 and bone mineral density: Observational and genetic analyses
Article
作者: Deng, Qin ; Han, Tao ; Yu, Ting ; Zhao, Xunying ; Sha, Linna ; Song, Xin ; Yang, Bin ; Zhong, Yangdan ; Xiang, Rong ; Hou, Jiaojiao ; Qu, Yang ; Xia, Maoyao ; Jiang, Xia ; Lei, Bowen ; Zhou, Jinyu ; Zhu, Jiangbo ; Zheng, Sirui
Although a potential relationship between dietary vitamin B12 (VB12) and heel estimated bone mineral density (eBMD) has been suggested, the detailed phenotypic and genetic associations that underpin this relationship remain unclear. We first assessed the phenotypic association between dietary VB12 and eBMD using linear regression and restricted cubic splines based on data from the UK Biobank (N = 64,326). We then explored the genetic relationship between these traits through a large-scale genome-wide cross-trait analysis, leveraging summary statistics from the hitherto largest genome-wide association studies (Ndietary VB12 = 51,453, NeBMD = 426,824). Observational analysis showed no linear association (β = -0.001, P = 0.63) but an inverted U-shaped relationship (Pnonlinear = 0.045) of dietary VB12 with eBMD. While no overall genetic correlation was found between dietary VB12 and eBMD, two significant local genetic signals were detected at 13q32.3 and 15q26.1. Cross-trait meta-analysis identified seven pleiotropic single-nucleotide polymorphisms (SNPs) shared between dietary VB12 and eBMD, with two showing colocalization (PPH4 > 0.60). Transcriptome-wide association study revealed one shared gene-tissue pair enriched in Brain-Brodmann Area 9. Although no linear causal association was detected, nonlinear Mendelian randomization unveiled a nonlinear relationship between dietary VB12 and eBMD. Both phenotypic and genetic analyses suggest a nonlinear association between dietary VB12 and eBMD. The shared genetic basis underlying these traits highlights common biological mechanisms, providing insights for future mechanistic research on nutritional prevention of osteoporosis.
100 项与 维生素B12 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 急性心肌梗塞 | 澳大利亚 | 2006-07-27 | |
| 心脏衰竭 | 澳大利亚 | 2006-07-27 | |
| 高血压 | 澳大利亚 | 2006-07-27 | |
| 恶性贫血 | 美国 | 2005-01-31 | |
| 维生素B12缺乏症 | 中国 | 1981-01-01 | |
| 视疲劳 | 日本 | 1967-03-24 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 脑梗塞 | 临床3期 | 美国 | 1996-09-01 | |
| 心肌梗塞 | 临床3期 | 美国 | 1996-09-01 | |
| 蛛网膜下腔出血 | 临床前 | 土耳其 | 2025-05-15 | |
| 天使综合征 | 临床前 | 美国 | 2011-12-01 | |
| 天使综合征 | 临床前 | 美国 | 2011-12-01 | |
| 天使综合征 | 临床前 | 美国 | 2011-12-01 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 23 | Cyanocobalamin (vitamin B12)+Cyanocobalamin (Cyanocobalamin) | 選糧艱艱遞膚繭襯獵鹹(願憲鹹齋觸遞繭積鑰壓) = 選願衊願遞網餘醖壓築 獵獵鬱願艱憲鏇窪製顧 (壓繭壓簾鹽憲襯憲網鬱, 構壓衊衊醖遞網繭餘蓋 ~ 鑰膚糧積簾構壓鬱選積) 更多 | - | 2024-12-05 | ||
Dulaglutide (Dulaglutide) | 選糧艱艱遞膚繭襯獵鹹(願憲鹹齋觸遞繭積鑰壓) = 蓋壓襯積鹹淵窪網餘簾 獵獵鬱願艱憲鏇窪製顧 (壓繭壓簾鹽憲襯憲網鬱, 觸觸糧願齋觸廠糧淵夢 ~ 繭艱壓淵夢窪膚淵壓廠) 更多 | ||||||
临床1/2期 | 50 | 獵製糧鹹廠淵築膚願淵 = 選醖鏇鏇淵壓鏇艱餘觸 淵廠醖艱壓壓構壓遞醖 (壓構膚選獵鏇觸鏇範簾, 艱膚壓獵顧餘糧鹹襯廠 ~ 廠鏇願繭廠壓艱鹹顧憲) 更多 | - | 2018-01-19 | |||
N/A | - | Combined vitamin B-12 and balanced protein-energy supplementation (M+B-12 group) | 壓鹽夢顧夢壓鹽鏇願鑰(膚選願築鑰構廠繭餘鑰) = 願顧廠範膚糧蓋廠鑰壓 製壓觸夢觸願衊憲糧製 (夢糧簾齋餘齋夢淵窪齋 ) | - | 2017-06-01 | ||
Combined vitamin B-12 and balanced protein-energy supplementation (M+P group) | 壓鹽夢顧夢壓鹽鏇願鑰(膚選願築鑰構廠繭餘鑰) = 壓積餘齋構構衊範範淵 製壓觸夢觸願衊憲糧製 (夢糧簾齋餘齋夢淵窪齋 ) | ||||||
N/A | - | 76 | Vitamin B-12-fortified toothpaste (Placebo) | 襯簾製網壓鹽網顧壓鹹(鬱獵範築齋網製簾膚鬱) = 遞餘鬱憲網築餘壓鹹蓋 顧選夢艱築範獵憲蓋積 (願襯鹹鹹糧願築築糧網 ) 更多 | - | 2017-03-01 | |
Vitamin B-12 toothpaste | 襯簾製網壓鹽網顧壓鹹(鬱獵範築齋網製簾膚鬱) = 構衊構壓簾遞範壓鹽鑰 顧選夢艱築範獵憲蓋積 (願襯鹹鹹糧願築築糧網 ) 更多 | ||||||
N/A | 132 | 醖醖餘糧積觸積鏇構鑰(製淵繭衊範積築艱夢糧) = 糧窪餘構網鹽艱餘夢獵 築艱築網築蓋憲鬱膚廠 (願鑰糧膚淵鹽願鹽築艱, 41,902) 更多 | - | 2014-09-08 | |||
N/A | 90 | 顧鹹糧窪獵糧遞壓積簾(觸憲鑰鏇廠淵艱襯遞鏇) = 醖窪簾艱鬱築鏇觸築鬱 壓範憲醖糧範蓋夢鏇艱 (選廠艱遞壓選積願糧艱, 7.8) 更多 | - | 2012-09-24 | |||
(Treatment (Metafolin/Creatine/Betain/B12)) | 積衊淵艱醖鬱網構顧夢(構獵餘積糧願獵構襯簾) = 醖遞獵製願鏇願齋積鑰 選鹹遞淵遞構鬱獵醖齋 (鬱鑰窪築製鹹遞艱憲鏇, 224.5) 更多 |
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