预约演示
更新于：2025-12-30
Cyanocobalamin
维生素B12
更新于：2025-12-30
概要
基本信息
原研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1967-03-24), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C63H88CoN14O14P |
InChIKeyDLRXOSFAWIKARM-SYUKHSAKSA-M |
CAS号68-19-9 |
关联
183
项与 维生素B12 相关的临床试验NCT06966856
Sublingual Versus Oral Vitamin B12 for Acute Hypovitaminosis B12 Secondary to Proton Pump Inhibitors: A Prospective Randomized Study
IRCT20250908067176N1
the effect of vitamin B12 supplementation on the outcome of patients with pneumosepsis
CTRI/2025/11/096925
An Open Labelled Randomized Standard Controlled Clinical Study On Efficacy Of Saptamruta Lauha In Vitamin B12 Deficiency (Pandu) - NIL
100 项与 维生素B12 相关的临床结果
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100 项与 维生素B12 相关的转化医学
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100 项与 维生素B12 相关的专利（医药）
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29,609
项与 维生素B12 相关的文献（医药）2026-03-01METABOLIC ENGINEERING
Metabolic engineering of Corynebacterium glutamicum for vitamin B12-independent production of 3-hydroxypropionic acid
Article
作者: Kim, Hyun Uk ; Lee, Sang Yup ; Moon, Cheon Woo ; Prabowo, Cindy Pricilia Surya ; Ghiffary, Mohammad Rifqi
3-Hydroxypropionic acid (3-HP) is a versatile platform chemical with broad applications, serving as a precursor for the synthesis of value-added chemicals as well as the biodegradable polymers. However, current industrial production of 3-HP relies on chemical synthesis, which requires harmful raw materials and harsh reaction conditions. As a sustainable alternative, microbial biosynthesis of 3-HP has gained increasing attention. Yet, most reported pathways remain constrained by their dependence on vitamin B12, a costly cofactor that limits scalability in industrial applications. Here, we report the development of a Corynebacterium glutamicum strain capable of high-level fermentative production of 3-HP from glucose via the introduction of a vitamin B12-independent, β-alanine-derived pathway. Candidate genes for the conversion of β-alanine to 3-HP were first screened, and the optimized pathway was subsequently introduced into a previously developed β-alanine-overproducing BAL10 strain. By eliminating competing pathways to increase precursor availability, redirecting carbon flux through the pentose phosphate pathway to improve cofactor balance, strengthening the β-alanine biosynthetic pathway, and identifying a previously uncharacterized 3-HP transporter followed by fine-tuning its expression, the final engineered strain produced 126.3 g/L of 3-HP in high-inoculum fed-batch fermentation, with a yield of 0.36 g/g glucose and an overall productivity of 1.75 g/L/h. These results demonstrate the feasibility of a vitamin B12-independent pathway for high-level 3-HP production, highlighting its potential for sustainable and scalable industrial application.
2026-02-01NUTRITION
Improved lipid and glycemic profile and vitamin D levels after a dietary intervention with SSRD and low FODMAP in IBS patients: A randomized controlled trial
Article
作者: D’Amato, Mauro ; Roth, Bodil ; Ohlsson, Bodil
BACKGROUND:
Irritable bowel syndrome (IBS) is the most common disorder of gut-brain interaction and associated with overweight. Low content of fermentable oligo-, di-, and monosaccharides and polyols (FODMAP) and a starch- and sucrose-reduced diet (SSRD) alleviate IBS symptoms, but restrictive diets may lead to malnutrition. The aim of the present clinical trial was to randomize IBS patients to either SSRD or low FODMAP and compare circulating metabolic and nutritional status over time.
METHODS:
Of 155 included patients, 77 received SSRD and 78 low FODMAP for 4 weeks, with a follow-up at 6 months. Study and Rome IV questionnaires, food diary, IBS-severity scoring system, and visual analog scale for IBS were completed, along with blood sampling and anthropometric measurements. Albumin, C-reactive peptide, glycosylated hemoglobin A1c (HbA1c) (mmol/mol), lipid profile (mmol/L), and micronutrients were analyzed in plasma/serum.
RESULTS:
Both diets improved gastrointestinal and extraintestinal symptoms. The weight reduction was most pronounced in SSRD (-1.6(-2.4 to [-0.4] kg vs. -0.8(-1.6 to [-0.1] kg; P = 0.006). Cholesterol (-0.1(-0.5 to 0.1), P = 0.007; -0.2(-0.4 to 0.1), P = 0.009), low-density lipoprotein (LDL) (-0.2(-0.4 to 0.1), P = 0.004; -0.1(-0.4 to 0.1), P = 0.017), and non-high-density lipoprotein (non-HDL) (-0.1(-0.4 to 0.1), P = 0.015; -0.1(-0.4 to 0.1), P = 0.008) decreased at week 4 and month 6 in the SSRD group, but only after 4 weeks in the low FODMAP group (-0.2(-0.5 to 0.2), P = 0.003; -0.1(-0.3 to 0.1), P = 0.036; and -0.2(-0.4 to 0.1), P = 0.002, respectively). At week 4, HbA1c decreased (0(-1.0 to 0), P = 0.010 and (0(-1.0 to 0), P = 0.009) and vitamin D increased (6(-3 to 16) nmol/L, P = 0.004 and 4(-5 to 14) nmol/L, P = 0.017) in both groups, with continued elevated vitamin D levels after SSRD. Folate increased and iron decreased in the SSRD group. Lower calcium and ferritin levels were found after low FODMAP. At 6 months, cobalamin was lower in both groups.
CONCLUSIONS:
SSRD and low FODMAP improve symptoms and the lipid, glycemic, and vitamin D profiles. The improved lipid and vitamin D profiles remained at follow-up in the SSRD group.
2026-02-01NUTRITION
Implementation of a standardized postoperative protocol enhances adherence to postoperative care and quality of life following bariatric surgery
Article
作者: Schaan, Beatriz D ; Trindade, Manoel R M ; Bahia, Luciana R ; Telo, Gabriela H ; Nascimento, Cigléa do ; Friedman, Rogério ; Maraschin, Clara K ; Viana, Luciana V ; Trindade, Manoel R.M. ; Blume, Carina A
BACKGROUND:
Postoperative care protocols vary among bariatric surgery centers, potentially affecting patient adherence to supplementation and follow-up care. Standardizing these protocols may improve treatment adherence and patient outcomes.
OBJECTIVES:
To assess the impact of implementing a standardized postoperative care protocol on patients' adherence to vitamin and mineral supplementation, multidisciplinary team follow-up, and health-related quality-of-life (HRQoL) during the first year after Roux-en-Y gastric bypass (RYGB).
METHODS:
This ambispective cohort study included patients undergoing RYGB at a Brazilian university hospital. Two groups were compared: those receiving the usual postoperative care (UC) and those managed under the new standardized protocol (SP). Adherence to supplementation and multidisciplinary appointments were assessed at 3, 6, and 12 months postsurgery. HRQoL was measured using a validated questionnaire at 12 months.
RESULTS:
Mean age was 42.3 ± 10.1 years and preoperative body mass index was 48.8 ± 8.3 kg/m². Adherence to multidisciplinary team follow-up was 81.7% in the UC and 96.9% in the SP (p = 0.003). The SP group showed higher vitamin D serum levels at 3, 6, and 12 months (p < 0.001). Overall, the percentage of multivitamin, calcium, vitamin D, and vitamin B12 use was remarkably lower in the UC group compared to the SP group, from 30 days to 1 year postoperative (p < 0.005). At 12 months, the SP group also showed higher scores of general health (p < 0.001) and social functioning (p = 0.004) in HRQoL.
CONCLUSIONS:
Implementing a standardized postoperative care protocol can improve patient adherence to treatment and quality of life after RYGB. This suggests that long-term outcomes for bariatric surgery patients could be optimized.
100 项与 维生素B12 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 急性心肌梗塞 | 澳大利亚 | 2006-07-27 | |
| 心脏衰竭 | 澳大利亚 | 2006-07-27 | |
| 高血压 | 澳大利亚 | 2006-07-27 | |
| 恶性贫血 | 美国 | 2005-01-31 | |
| 维生素B12缺乏症 | 中国 | 1981-01-01 | |
| 视疲劳 | 日本 | 1967-03-24 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 脑梗塞 | 临床3期 | 美国 | 1996-09-01 | |
| 心肌梗塞 | 临床3期 | 美国 | 1996-09-01 | |
| 蛛网膜下腔出血 | 临床前 | 土耳其 | 2025-05-15 | |
| 天使综合征 | 临床前 | 美国 | 2011-12-01 | |
| 天使综合征 | 临床前 | 美国 | 2011-12-01 | |
| 天使综合征 | 临床前 | 美国 | 2011-12-01 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 23 | Cyanocobalamin (vitamin B12)+Cyanocobalamin (Cyanocobalamin) | 獵廠蓋顧構衊鹹衊餘遞(簾選鏇餘夢繭範鹽襯遞) = 遞廠鑰膚鹹鬱簾構夢鬱 顧構夢築繭襯範淵遞繭 (遞範觸網蓋窪網膚壓糧, 簾齋衊願觸蓋構網淵膚 ~ 遞觸願觸壓餘艱艱獵鬱) 更多 | - | 2024-12-05 | ||
Dulaglutide (Dulaglutide) | 獵廠蓋顧構衊鹹衊餘遞(簾選鏇餘夢繭範鹽襯遞) = 醖餘鏇範襯醖鬱願夢廠 顧構夢築繭襯範淵遞繭 (遞範觸網蓋窪網膚壓糧, 鹽範襯糧築衊窪壓夢餘 ~ 膚窪簾廠積廠衊衊鬱鑰) 更多 | ||||||
临床1/2期 | 50 | 積範網製襯製獵遞夢壓 = 蓋範鑰艱顧簾齋窪簾醖 網獵願淵衊選蓋壓衊範 (壓築膚齋簾獵餘觸艱簾, 餘積衊顧構觸淵觸獵窪 ~ 鏇顧齋鹹繭夢獵醖鏇艱) 更多 | - | 2018-01-19 | |||
N/A | - | Combined vitamin B-12 and balanced protein-energy supplementation (M+B-12 group) | 鏇範選鏇製構鏇簾衊糧(艱簾獵選構範鬱餘選醖) = 鏇淵顧糧鏇簾構憲壓夢 製願網壓艱艱糧鹹窪鏇 (糧壓夢構膚獵範壓鏇觸 ) | - | 2017-06-01 | ||
Combined vitamin B-12 and balanced protein-energy supplementation (M+P group) | 鏇範選鏇製構鏇簾衊糧(艱簾獵選構範鬱餘選醖) = 鑰觸餘選積衊蓋窪構鑰 製願網壓艱艱糧鹹窪鏇 (糧壓夢構膚獵範壓鏇觸 ) | ||||||
N/A | - | 76 | Vitamin B-12-fortified toothpaste (Placebo) | 淵積觸窪糧獵蓋糧選廠(觸網願積憲餘夢窪遞簾) = 選齋顧願醖構觸遞鑰蓋 餘餘獵襯鏇網鏇壓遞糧 (獵網廠廠鬱齋齋鏇願積 ) 更多 | - | 2017-03-01 | |
Vitamin B-12 toothpaste | 淵積觸窪糧獵蓋糧選廠(觸網願積憲餘夢窪遞簾) = 鏇積鏇窪顧願積蓋獵製 餘餘獵襯鏇網鏇壓遞糧 (獵網廠廠鬱齋齋鏇願積 ) 更多 | ||||||
N/A | 132 | 願選選衊鹽觸觸顧齋觸(鏇窪鏇蓋願衊壓積簾醖) = 獵艱艱膚齋鹹願憲積艱 壓襯獵鹽願艱窪憲築顧 (顧鹹壓淵獵齋壓鹹襯壓, 41,902) 更多 | - | 2014-09-08 | |||
N/A | 90 | 顧窪淵鹹醖顧簾蓋壓遞(膚膚艱窪廠網鹽範膚鏇) = 選觸鹹齋衊鹽顧餘夢網 積壓壓網膚衊蓋繭簾簾 (顧網範襯襯醖鹽艱觸膚, 7.8) 更多 | - | 2012-09-24 | |||
(Treatment (Metafolin/Creatine/Betain/B12)) | 遞鹹醖餘選糧遞繭憲壓(餘廠觸艱齋夢鹽艱淵構) = 願製憲鏇襯壓餘築鹽鏇 糧製製網醖鹹鹽構製壓 (壓鑰簾鬱醖願構窪廠製, 224.5) 更多 |
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