预约演示
更新于：2025-08-17
Cyanocobalamin
维生素B12
更新于：2025-08-17
概要
基本信息
原研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1967-03-24), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C63H88CoN14O14P |
InChIKeyDLRXOSFAWIKARM-SYUKHSAKSA-M |
CAS号68-19-9 |
关联
157
项与 维生素B12 相关的临床试验NCT06966856
Sublingual Versus Oral Vitamin B12 for Acute Hypovitaminosis B12 Secondary to Proton Pump Inhibitors: A Prospective Randomized Study
CTRI/2025/06/089254
Comparison of high dose vitamin B12 versus standard dose vitamin B12 supplementation in preterm neonates born at 28 to 33 weeks of gestation- a randomized controlled trial - NIL
CTRI/2025/06/088909
Comparing the efficacy of oral versus injectable vitaminB12 in patients with Neurocutaneous Infantile VitaminB12 deficiency Syndrome (NIBS): A RandomizedControlled Trial - NIL
100 项与 维生素B12 相关的临床结果
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100 项与 维生素B12 相关的转化医学
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100 项与 维生素B12 相关的专利（医药）
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32,957
项与 维生素B12 相关的文献（医药）2025-12-31RENAL FAILURE
Healthy Eating Index-2015, a protective factor for mitochondria-derived methylmalonic acid in the low poverty/income ratio with chronic kidney diseases: results from NHANES 2011–2014
Article
作者: Lin, Tao ; Zhang, Hao ; Yang, Yaqing ; Bai, Yunjin ; Xiao, Yunfei ; Wang, Jia
OBJECTIVE:
Serum methylmalonic acid (MMA) arises from impaired metabolism of methylmalonyl-CoA and is exacerbated in chronic kidney disease (CKD) due to reduced renal clearance and nutritional deficiencies. The quality of diet may influence MMA levels by affecting vitamin B12 intake and mitigating inflammatory dietary components. This study aims to explore the relationship between the Healthy Eating Index-2015 (HEI-2015) and the prevalence of high MMA among low poverty/income ratio (PIR) patients with CKD.
METHOD:
We conducted a cross-sectional study of participants aged ≥20 years using the data drawn from the NHANES 2011-2014. Individuals under low PIR suffering from CKD were included. HEI-2015 was calculated to evaluate diet quality. Multivariable logistic regression models were applied to examine the association between HEI-2015 and high MMA prevalence with covariates adjusted. Stratified and interaction analysis were also performed.
RESULTS:
A total of 582 CKD patients with low PIR were enrolled. The logistic analysis showed that higher HEI-2015 was significantly associated with a lower prevalence of high MMA. Patients in the highest quartile of HEI-2015 scores (>61.17) showed a 57.8% reduction in high MMA prevalence compared to those in the lowest quartile. Subgroup and interaction analysis revealed that alcohol consumption reduced the diet quality-related protection against high MMA.
CONCLUSION:
The protective role of high-quality diets, as reflected by HEI-2015, in reducing the prevalence of high MMA in low PIR CKD patients is noteworthy. Improving diet quality in this population could potentially mitigate the risks associated with high MMA in CKD patients with low PIR.
2025-12-31Journal of Maternal-Fetal & Neonatal Medicine
Assessing the relationship between serum vitamin A, C, E, D, and B12 levels and preeclampsia
Article
作者: Hu, Zhenhua ; Yang, Wenjiao ; Gu, Weirong
OBJECTIVE:
Micronutrients play an important role in maintaining physiological functions while preventing complications associated with pregnancy. The main aim of this study was to evaluate the possible associations between vitamins A, C, D, E, B12, and preeclampsia using a retrospective analytical approach.
METHODS:
This retrospective study enrolled pregnant women who attended routine antenatal checkups between January 2021 and January 2023 at the Obstetrics and Gynecology Hospital of Fudan University. One thousand pregnant women aged 18-50 years whose serum vitamin assessments were conducted during 12-20 weeks of gestation were enrolled. Inclusion criteria: women with preeclampsia, singleton pregnancies, and no previous history of hypertension or preeclampsia. Exclusion criteria: metabolic disorders, multiple pregnancies, and other specified exclusions. Approval of the hospital's ethics committee; all participants gave written informed consent. Demographic data analyzed include age, BMI, and gestational age, showing no significant differences in age span between groups (p > .05).
RESULTS:
In the preeclampsia group, the serum level of vitamin A stands at 1.08 ± 0.29 μmol/L, which is lower than the control group of 1.13 ± 0.31 μmol/L (p < .05). Mean serum levels of vitamin C in preeclampsia are 51.81 ± 13.15 μmol/L, which was lower than in the control group, where it was 59.67 ± 16.40 μmol/L (p < .05). The mean serum vitamin B12 level in preeclampsia is 158.28 ± 46.77 pmol/L, lower than the 165.61 ± 40.99 pmol in the control group (p < .05). The two groups had no significant difference in serum vitamin E and vitamin D levels (p > .05).
CONCLUSION:
Serum vitamins A, C, and B12 at 12 to 20 weeks of pregnancy might be important predisposing factors for preeclampsia. They can be used as indicators of preeclampsia severity and offer clinical detection even before the patient presents with symptoms.
2025-12-01Genes and Nutrition
Exploring causal relationships between circulating micronutrients and age-related eye diseases: a Mendelian randomization study
Article
作者: Cao, Xiang ; Yuan, Xiaoyong ; Zhang, Boyang ; Xu, Zijiao ; Jiang, Zhixin
BACKGROUND:
With the global population aging, age-related eye diseases (AREDs) such as senile cataract (SC), age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy (DR) are becoming increasingly significant public health concerns. The rising prevalence of AREDs underscores the urgent need for effective prevention and treatment strategies. This study aimed to explore the causal relationships between circulating micronutrients (CMs) and AREDs.
METHODS:
A bidirectional two-sample Mendelian randomization (MR) analysis was conducted using genetic variants as instrumental variables to assess the effects of fifteen CMs (vitamin A, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, folate, carotene, copper, calcium, iron, magnesium, potassium, selenium, zinc) on AREDs. Data were sourced from large-scale genome-wide association studies (GWAS). The primary analytical method employed was inverse-variance weighted (IVW), supplemented by sensitivity analyses to confirm the robustness of the results.
RESULTS:
The MR analysis revealed significant protective effects of selenium against SC (OR = 0.961, 95% CI = 0.932-0.991, P = 0.012) and DR (OR = 0.927, 95% CI = 0.870-0.987, P = 0.019). Furthermore, higher genetically predicted magnesium levels were associated with a reduced risk of AMD (OR = 0.679, 95% CI = 0.515-0.895, P = 0.006). However, no significant causal relationships were observed between the other CMs and glaucoma or other AREDs.
CONCLUSIONS:
These findings provided valuable insights into the complex interplay between CMs and AREDs, offering potential pathways for developing targeted nutritional interventions and public health strategies to mitigate the risk of these debilitating conditions.
100 项与 维生素B12 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 急性心肌梗塞 | 澳大利亚 | 2006-07-27 | |
| 心脏衰竭 | 澳大利亚 | 2006-07-27 | |
| 高血压 | 澳大利亚 | 2006-07-27 | |
| 恶性贫血 | 美国 | 2005-01-31 | |
| 维生素B12缺乏症 | 中国 | 1981-01-01 | |
| 视疲劳 | 日本 | 1967-03-24 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 脑梗塞 | 临床3期 | 美国 | 1996-09-01 | |
| 心肌梗塞 | 临床3期 | 美国 | 1996-09-01 | |
| 蛛网膜下腔出血 | 临床前 | 土耳其 | 2025-05-15 | |
| 天使综合征 | 临床前 | 美国 | 2011-12-01 | |
| 天使综合征 | 临床前 | 美国 | 2011-12-01 | |
| 天使综合征 | 临床前 | 美国 | 2011-12-01 |
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临床结果
临床结果
适应症
分期
评价
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临床1/2期 | 50 | 築選壓鏇醖淵鹽獵鏇積 = 鬱夢廠淵網窪範艱膚餘 觸餘鏇膚鹽構膚糧膚構 (夢夢壓鏇膚蓋積壓艱糧, 繭餘蓋構繭醖夢網選衊 ~ 遞觸齋簾襯積構鏇艱衊) 更多 | - | 2018-01-19 | |||
N/A | - | Combined vitamin B-12 and balanced protein-energy supplementation (M+B-12 group) | 淵構積願積衊艱鑰艱膚(憲壓鹹鹹鏇蓋鏇鏇範構) = 憲淵築願繭顧構鹹選餘 範鹽齋醖憲膚觸鹹築積 (鏇鬱範積積憲襯獵壓築 ) | - | 2017-06-01 | ||
Combined vitamin B-12 and balanced protein-energy supplementation (M+P group) | 淵構積願積衊艱鑰艱膚(憲壓鹹鹹鏇蓋鏇鏇範構) = 衊網製襯憲齋製鏇願願 範鹽齋醖憲膚觸鹹築積 (鏇鬱範積積憲襯獵壓築 ) | ||||||
N/A | - | 76 | Vitamin B-12-fortified toothpaste (Placebo) | 夢鏇艱繭齋淵簾顧淵製(鏇築觸鹹艱醖膚鏇淵夢) = 窪襯淵顧築壓艱網襯廠 鹽艱網憲醖鹹鏇製淵遞 (選蓋廠糧鹹鏇淵夢遞膚 ) 更多 | - | 2017-03-01 | |
Vitamin B-12 toothpaste | 夢鏇艱繭齋淵簾顧淵製(鏇築觸鹹艱醖膚鏇淵夢) = 繭膚膚築廠襯襯壓築觸 鹽艱網憲醖鹹鏇製淵遞 (選蓋廠糧鹹鏇淵夢遞膚 ) 更多 | ||||||
N/A | 281 | 膚網襯鹽積鑰蓋繭壓齋(夢網構鹹網窪鏇選餘簾) = 獵廠鏇廠遞鏇襯製淵蓋 糧廠襯網襯襯願獵積膚 (壓積鏇鹹觸糧鬱艱積範 ) | 积极 | 2016-05-20 | |||
膚網襯鹽積鑰蓋繭壓齋(夢網構鹹網窪鏇選餘簾) = 遞夢齋鏇獵獵網簾獵鹹 糧廠襯網襯襯願獵積膚 (壓積鏇鹹觸糧鬱艱積範 ) | |||||||
N/A | 132 | 簾築網範艱窪蓋膚網鬱(鬱襯壓選顧製築網製觸) = 鬱願窪膚壓網艱窪鏇築 鏇鹽艱蓋蓋積蓋衊鏇鹽 (鬱積顧遞憲襯鏇鹽淵簾, 41,902) 更多 | - | 2014-09-08 | |||
N/A | 90 | 醖糧鬱衊鏇壓網簾積願(膚憲顧築鬱鏇積憲鹽糧) = 鏇網網簾構膚鹹鏇齋鏇 鹽窪廠齋願蓋鹹鑰繭襯 (鹽艱壓範鹹衊遞範簾壓, 7.8) 更多 | - | 2012-09-24 | |||
(Treatment (Metafolin/Creatine/Betain/B12)) | 選網積糧簾製憲壓鹽積(遞範糧蓋膚鏇襯窪顧選) = 憲鬱鑰繭積築繭遞夢積 壓憲製顧淵衊鬱齋選壓 (餘艱糧淵選獵築鏇廠獵, 224.5) 更多 |
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