预约演示
更新于：2026-01-02
Dulaglutide
度拉糖肽
更新于：2026-01-02
概要
基本信息
原研机构 |
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (2014-09-18), |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构/序列
Sequence Code 51033
来源: *****
关联
132
项与 度拉糖肽 相关的临床试验NCT07309614
A Multinational, Investigator-initiated, Parallel Group, Randomised, Double-blind, Placebo-controlled Phase 3b Superiority Trial Assessing the Effect of Dupilumab on Inducing Clinical Remission Outcomes in At-risk Type-2 Inflammatory Asthma (HOTHOT)
This study tests whether an asthma medication called dupilumab can help people achieve complete asthma control (called "remission") when given earlier in their disease, before asthma becomes severe. Currently, most people with asthma only receive advanced treatments like biologics after their condition has worsened significantly and caused lung damage. This study explores whether treating high-risk patients earlier could prevent asthma attacks and lung function decline, potentially achieving remission before permanent damage occurs. The study is looking for adults aged 18-79 with moderate asthma who have had at least one asthma attack requiring steroid pills in the past 2 years, use medium or high-dose inhaled steroids regularly, have high levels of inflammation markers in their blood and breath tests, but don't yet meet criteria for severe asthma requiring biologic therapy. Participants receive either dupilumab or placebo injections every 2 weeks for one year, alongside their regular asthma medications. They attend clinic visits every 3 months for breathing tests, questionnaires, and safety monitoring. Neither participants nor doctors know who receives the real medication until the study ends. The goal is to learn whether early treatment with dupilumab helps more people achieve complete asthma control compared to standard care alone, potentially changing how asthma is treated from "waiting until severe" to "preventing severe disease." The study runs in Canada, the United Kingdom, and Australia, involving 150 participants
开始日期2026-01-01 |
申办/合作机构 |
NCT07282041
Role of Glucagon-like Peptide 1 Receptor Agonist (GLP1 RA) Dulaglutide on Cerebral Hemodynamics In Patients With Severe and symptomAtic steNosis of inTracranial Internal Carotid Artery or Middle Cerebral Artery With Impaired Cerebral Vasodilatory Reserve- an Open-label Randomised Clinical Trial (RADIANT)
One important mechanism of action of GLP1 RA is the improvement in endothelial function, which may be evaluated by the assessment of cerebral vasodilatory reserve (CVR) in patients with severe ICAD. The investigators believe that GLP1 RA would be beneficial for patients with severe ICAD and lead to an improvement in cerebral vasodilatory reserve (CVR) in patients with severe and recently symptomatic stenosis of intracranial carotid artery (ICA) or middle cerebral artery (MCA).
In this open label randomised clinical trial, patients with recently symptomatic and severe stenosis of intracranial carotid artery (ICA) or middle cerebral artery (MCA) with impaired cerebral vasodilatory reserve (CVR) will be included. CVR will be measured with transcranial Doppler (TCD) breath holding index and acetazolamide-challenged single photon emission computed tomography (SPECT). Patients meeting the eligibility criteria would be randomised to receive best medical therapy (according to the international guidelines and institutional practices) or Dulaglutide subcutaneous injection (0.75mg and titrating to 1.5mg, if indicated) once a week, in addition to the best medical therapy. CVR will be measured again at the completion of 1 year. MRI of the brain will be repeated to evaluate any new ischaemic brain lesions. All patients would be followed up for two years for cerebral ischaemic events.
The investigators hypothesize that addition of GLP1 RA therapy would lead to a reduction of at least 4 units in CVR on SPECT as compared to best medical therapy.
In this open label randomised clinical trial, patients with recently symptomatic and severe stenosis of intracranial carotid artery (ICA) or middle cerebral artery (MCA) with impaired cerebral vasodilatory reserve (CVR) will be included. CVR will be measured with transcranial Doppler (TCD) breath holding index and acetazolamide-challenged single photon emission computed tomography (SPECT). Patients meeting the eligibility criteria would be randomised to receive best medical therapy (according to the international guidelines and institutional practices) or Dulaglutide subcutaneous injection (0.75mg and titrating to 1.5mg, if indicated) once a week, in addition to the best medical therapy. CVR will be measured again at the completion of 1 year. MRI of the brain will be repeated to evaluate any new ischaemic brain lesions. All patients would be followed up for two years for cerebral ischaemic events.
The investigators hypothesize that addition of GLP1 RA therapy would lead to a reduction of at least 4 units in CVR on SPECT as compared to best medical therapy.
开始日期2025-12-17 |
NCT07313813
A Study to Evaluate the Effect of Fasting Duration and Temporary Withholding of Dulaglutide on Retained Gastric Contents Using Gastric Ultrasound in Participants With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate how fasting and stopping the use of Dulaglutide (LY2189265) affect the amount of food and drink that stays in your stomach after a meal.
Ultrasound devices will be used to check the stomach content after a test meal.
The study can last approximately 28 weeks.
Ultrasound devices will be used to check the stomach content after a test meal.
The study can last approximately 28 weeks.
开始日期2025-12-01 |
申办/合作机构 |
100 项与 度拉糖肽 相关的临床结果
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100 项与 度拉糖肽 相关的转化医学
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100 项与 度拉糖肽 相关的专利（医药）
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1,227
项与 度拉糖肽 相关的文献（医药）2026-01-01·TOXICON
Computational modelling the impact of GLP-1 receptor agonists on botulinum toxin A: Evidence for reduced treatment durability across neurologic and aesthetic indications
Article
作者: Rao, Parinitha ; Joseph, John H ; Rahman, Eqram ; Ahmed, Munim ; Carruthers, Jean DA ; Webb, William Richard ; Wu, Woffles Tl ; Michon, Alain
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have transformed metabolic and aesthetic medicine, yet their potential influence on botulinum toxin type A (BoNT-A) pharmacodynamics remains unexplored. Using the AesthetiSIM™ microsimulation platform, a transparent, parameterized in-silico model was developed to estimate whether GLP-1-related changes in metabolism and neuromuscular recovery could alter toxin durability. Twenty-five thousand virtual patients were generated, representing two domains of BoNT-A use: chronic migraine (n = 20,000) and masseter prominence (n = 5000). Virtual subjects were randomly assigned to semaglutide, tirzepatide, liraglutide, dulaglutide, or control conditions, and simulated over one year under standardized 100-unit BoNT-A dosing. The framework incorporated three mechanistic domains-synaptic modulation via cAMP-PKA-mediated SNAP-25 phosphorylation, lean-mass reduction affecting diffusion kinetics, and systemic metabolic variability reflecting diabetic or rapid-weight-loss phenotypes. In chronic migraine, mean BoNT-A duration declined from 14.0 ± 2.3 weeks in controls to 12.6, 12.5, 12.2, and 11.8 weeks across GLP-1 exposures (all p < 0.001; hazard ratio range 1.54-1.95). In masseter prominence, mean duration decreased from 20.1 ± 2.9 weeks to 17.3, 17.0, 16.7, and 16.2 weeks, with hazard ratios 1.72-2.08. Early wear-off and uncovered symptomatic periods rose proportionally across agents, with the hierarchy tirzepatide > liraglutide > dulaglutide > semaglutide. Sensitivity analyses indicated that approximately 55 % of the reduction in duration was attributable to synaptic modulation, 30 % to lean-mass decline, and 15 % to metabolic variability. These findings suggest a biologically plausible interaction between GLP-1 signalling and BoNT-A recovery dynamics. The results are exploratory and derive entirely from computational modelling rather than clinical observation. Experimental validation-such as neuronal culture assays or prospective patient cohorts-is required before any modification of treatment intervals or dosing practices can be considered.
2026-01-01·DIABETES OBESITY & METABOLISM
Comparison of the renal outcomes of novel antidiabetic agents in patients with type 2 diabetes with chronic kidney disease: A systematic review and network meta‐analysis of randomized controlled trials
Review
作者: Rong Lin MD ; Kuo-Liong Chien PhD ; Ming-Chieh Shih PhD ; Chia-Li Hsu MD ; Hon-Yen Wu PhD
Abstract:
Aims:
To investigate the renal outcomes of dipeptidyl peptidase 4 (DPP‐4) inhibitors, glucagon‐like peptide‐1 (GLP‐1) receptor agonists, and sodium‐glucose transport protein‐2 (SGLT‐2) inhibitors in patients with type 2 diabetes mellitus (T2DM) with chronic renal disease (CKD).
Materials and Methods:
PubMed, Embase, Cochrane CENTRAL, and
ClinicalTrials.gov
were searched through July 2025 for randomized controlled trials with ≥24 weeks of follow‐up in patients with T2DM and CKD. Outcomes included composite renal outcome, estimated glomerular filtration rate (eGFR), and urinary albumin‐to‐creatinine ratio (UACR). A network meta‐analysis was conducted, and the certainty of evidence was assessed with the Grading of Recommendations Assessment, Development, and Evaluation used to evaluate evidence certainty (GRADE).
Results:
Twenty RCTs enrolling 80,670 participants were included. Compared with placebo, several agents significantly reduced composite renal outcomes, with dapagliflozin 10 mg showing the greatest efficacy (OR 0.55, 95% CI 0.42–0.72; high‐certainty evidence), followed by canagliflozin, empagliflozin, efpeglenatide, sotagliflozin 400 mg, semaglutide, and dulaglutide 1.5 mg. Canagliflozin 100–300 mg significantly reduced UACR, whereas dapagliflozin had no effect. None of the novel antidiabetic agents significantly altered eGFR. Certainty of evidence ranged from high for placebo‐controlled comparisons to low or very low for indirect estimates.
Conclusions:
In patients with T2DM and CKD, SGLT2 inhibitors provide the most consistent renal protection, while GLP‐1 receptor agonists offer additional but variable benefits. Dapagliflozin showed the greatest efficacy, and canagliflozin most strongly reduced albuminuria, highlighting meaningful heterogeneity across agents. DPP‐4 inhibitors conferred no renal benefit. Overall, evidence from placebo‐controlled trials was robust, whereas certainty was lower for indirect estimates, highlighting the need for drug‐specific evaluation in clinical practice.
2026-01-01·AMERICAN JOURNAL OF CARDIOLOGY
GLP-1 Receptor Agonists and Cardiovascular Outcomes in Adults With Diabetes and Peripheral Artery Disease: An Updated Systematic Review and Meta-Analysis
Review
作者: Shuja, Syed Hasan ; Adam, Siad ; Ahmed, Ilsa ; Hannat, Ramish ; Changez, Mah I Kan ; Abdelkhalek, Ahmed ; Ahmed, Raheel ; Ullah, Irfan ; Shuja, Muhammad Hamza ; Cortese, Bernardo ; Shaukat, Ayesha
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) provide proven cardiovascular benefits in type 2 diabetes mellitus (T2DM) and heart failure, but their effects in patients with peripheral artery disease (PAD) remain unclear. PAD is common in T2DM and increases the risk of adverse cardiovascular and limb outcomes. This meta-analysis assessed the impact of GLP-1 RAs on cardiovascular and limb-related outcomes in patients with T2DM and PAD. A systematic search of PubMed, Cochrane CENTRAL, ScienceDirect, and ClinicalTrials.gov was conducted through May 24, 2025. Primary outcomes included all-cause mortality (ACM) and cardiovascular mortality (CVM). Secondary outcomes were major adverse cardiovascular events (MACE), myocardial infarction, stroke, major adverse limb events (MALE), glycemic control (HbA1c), body weight, and adverse events. Pooled risk ratios and mean differences were calculated using random-effects models. Six randomized controlled trials, including 7,645 participants met the inclusion criteria. GLP-1 RAs significantly reduced ACM (RR 0.83, 95% CI 0.70 to 0.99, p = 0.04, I² = 0%), MACE (RR 0.86, 95% CI 0.76 to 0.98, p = 0.02, I² = 0%), and improved HbA1c (MD -0.72%, p = 0.02), with no significant effect on weight, major adverse limb events (MALE), CVM, myocardial infarction, or stroke. In conclusion, GLP-1 RAs lower MACE and ACM in patients with T2DM and PAD but do not clearly benefit limb-specific outcomes, highlighting the need for larger, PAD-focused trials to clarify their role in limb protection.
1,563
项与 度拉糖肽 相关的新闻（医药）2026-01-01
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截至01月01日15点59分，近期共有 293 本期刊发布了 930 篇文章，其中糖尿病相关的文章共 312 篇，覆盖 28 个领域的内容。中国专家参与发表的文章有 70 篇。今日，影响因子最高的文章刊登在 iMeta (IF: 33.200) 期刊上。
今日头条
Headlines
01 iMeta IF: 33.200 单细胞空间转录组学揭示Abelmoschus manihot (L.) Medic治疗糖尿病肾病的潜在分子机制
Wu, Chenhua, Tang, Haitao, Yu, Yihong, Song, Yuhui, Ge, Haitao, Shen, Yiming, etc.
糖尿病肾病（DKD）作为糖尿病最常见且严重的微血管并发症之一，是全球终末期肾病的主要原因，给患者和社会带来沉重负担。尽管现有治疗策略不断优化，但探索更有效、多靶点的治疗方案仍是医学研究的重要方向。近年来，传统中药在DKD治疗中显示出独特优势，其中源自中药黄蜀葵花（Abelmoschus manihot (L.) Medic）的制剂——黄葵胶囊（HKC）在临床应用中表现出良好的疗效。
近日，一项发表于 iMeta 期刊的研究，结合前沿的单细胞空间转录组学技术，深入揭示了黄蜀葵花核心活性成分——总黄酮（TFA）治疗DKD的潜在分子机制。该研究由 Chenhua Wu、Haitao Tang、Harvest F. Gu 等学者共同完成。
研究团队以经典的2型糖尿病及DKD动物模型——db/db小鼠为研究对象，将其分为正常对照组、DKD模型组、TFA治疗组以及阳性对照药厄贝沙坦（IRB）治疗组。经过为期四周的干预，研究人员确认，TFA单药治疗能够显著降低db/db小鼠的尿蛋白水平，并有效改善肾脏组织学上的病理损伤，包括肾小球硬化、基底膜增厚和炎性细胞浸润，其疗效与TFA联合IRB或IRB单药治疗相当。
为了在空间维度上解析TFA的作用机制，研究采用了高分辨率的空间转录组学技术，成功绘制了db/db小鼠肾脏在疾病状态及药物干预下的单细胞水平空间基因表达图谱。该图谱精准识别并定位了肾脏中包括近端小管细胞、髓袢细胞、集合管主细胞、足细胞、内皮细胞、系膜细胞以及巨噬细胞、T细胞等在内的16种主要细胞类型。
通过对空间转录组数据的深度挖掘，研究人员构建了肾脏细胞的转录调控网络。他们发现，在DKD发生发展过程中，一组关键的转录调节因子，如Stat1、Jun、Junb等，在多种肾脏实质细胞和免疫细胞中的活性显著增强。而无论是TFA还是IRB治疗，均能有效抑制这些调节因子的异常活性。
进一步追溯其上游，研究发现，这些关键调节因子的活性受到特定细胞表面受体的调控。例如，整合素受体Itgb5的表达在DKD模型的巨噬细胞和集合管主细胞中升高，而TFA和IRB治疗可使其表达下调。分子对接模拟分析提示，TFA中的活性成分槲皮素可能与Itgb5结合，进而抑制其下游的Stat1信号通路。同时，TFA中的多种黄酮类成分可能共同作用于转化生长因子-β受体Tgfbr1，抑制其介导的促纤维化信号。
该研究从单细胞空间分辨率的视角，系统描绘了TFA干预DKD的分子图谱，揭示了其通过调控Itgb5-Stat1、Tgfbr1等关键受体-调节因子轴，减轻肾脏免疫炎症反应和纤维化进程，从而发挥肾脏保护作用的潜在机制。这些发现为阐明中药黄蜀葵花治疗糖尿病肾病的现代科学内涵提供了重要的实验依据，也为未来开发多靶点抗DKD药物提供了新的思路和靶点。
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iMeta | Volume 4, Issue 6
10.1002/imt2.70099
02 Nature methods IF: 32.100 cellSTAAR：整合单细胞测序功能数据以增强非编码区罕见变异关联检验效力
Van Buren, Eric, Zhang, Yi, Li, Xihao, Selvaraj, Margaret Sunitha, Li, Zilin, Zhou, Hufeng, etc.
近日，一项发表于 Nature methods 的研究介绍了一种名为cellSTAAR的创新分析方法，该方法旨在破解非编码区罕见遗传变异影响复杂性状的难题。该研究由 Eric Van Buren、Yi Zhang、Xihao Li 等来自多所研究机构的众多学者共同完成。
理解罕见遗传变异如何影响如血脂水平等复杂性状，是现代遗传学面临的主要挑战之一，尤其当这些变异位于基因组的非编码区域时。这些位于候选顺式调控元件内的变异，其效应常常因细胞类型而异，这为解读工作带来了巨大困难。为此，研究者开发了cellSTAAR。
cellSTAAR的核心在于数据整合与策略创新。该方法将大规模人群的全基因组测序数据，与能够揭示染色质可及性在不同细胞类型中差异的单细胞ATAC测序数据相结合。通过这种整合，cellSTAAR能够构建出细胞类型特异性的功能注释和调控元件图谱。更重要的是，为了应对cCREs（候选顺式调控元件）与靶基因之间关联的不确定性，该方法采用了一套综合性的策略来链接cCREs与其可能调控的基因，从而更全面地捕捉潜在的基因调控网络。
为了验证cellSTAAR的效力，研究团队将其应用于两个大型人群队列。首先，他们在Trans-Omics for Precision Medicine联盟约60,000人的数据中进行了分析。随后，为了确保结果的可靠性，他们在规模更大的UK Biobank约190,000人的数据中进行了独立验证。研究的焦点集中在四种重要的血脂性状上。
分析结果表明，与不整合细胞类型特异性信息的方法相比，cellSTAAR显著提升了对非编码区罕见变异与血脂性状关联的检测能力。更重要的是，该方法发现的关联信号具有更强的生物学可解释性，能够更清晰地指向特定细胞类型中可能受影响的调控通路。这些发现证明，在基于全基因组测序的罕见变异关联研究中，采用这种细胞类型感知的策略，可以有效推动新发现并加深我们对复杂性状遗传基础的理解。
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Nature methods | Ahead of Print.
10.1038/s41592-025-02919-5
03 Gut : IF: 25.800 代谢功能障碍相关脂肪性肝炎的联合疗法：挑战与机遇
Zhou, Xiao-Dong, Fan, Qiong-Yue, Byrne, Christopher D, Targher, Giovanni, Muthiah, Mark D, Huang, Daniel Q, etc.
近日，一篇发表于《Gut》期刊的综述文章《Combination therapies for metabolic dysfunction-associated steatohepatitis: challenges and opportunities》深入探讨了针对代谢功能障碍相关脂肪性肝炎（MASH）的联合治疗策略。MASH作为一种与肥胖、胰岛素抵抗等心脏代谢共病密切相关的复杂肝病，其治疗正面临从单药到多药联合的范式转变。
该文章指出，由于MASH发病机制涉及多条通路，传统的单药治疗往往只能带来肝脏纤维化和全身代谢参数的部分改善，疗效有限。这促使研究人员和临床医生将目光投向了能够同时作用于多个互补靶点的联合疗法。文章强调，这种多靶点策略旨在通过协同作用，达到比任何单一药物更优的治疗效果。
具体而言，联合疗法可以从不同维度设计。一类是专注于肝脏本身的“肝脏导向”组合，例如将甲状腺激素受体-β（THR-β）激动剂与乙酰辅酶A羧化酶（ACC）抑制剂或过氧化物酶体增殖物激活受体（PPAR）激动剂联用，其主要目标是更有效地改善肝脏脂肪变性、炎症和纤维化等核心组织学病变。
另一类策略则将改善全身代谢状态与针对肝脏的特异性作用结合起来。例如，胰高血糖素样肽-1（GLP-1）受体激动剂在有效降低体重、改善血糖的同时，若与成纤维细胞生长因子-21（FGF-21）类似物或THR-β激动剂联合，有望实现对肝脏和全身代谢指标的双重优化，为患者带来更全面的健康获益。
值得注意的是，联合用药还可能解决单药治疗中的安全性瓶颈。文章提到，一些经过深思熟虑的药物配对能够利用其机制的互补性来抵消彼此潜在的副作用。例如，二酰基甘油O-酰基转移酶2（DGAT2）抑制剂与ACC抑制剂的组合，或者GLP-1/胰高血糖素双重受体激动剂，其设计初衷之一就是提高整体的安全性和患者的耐受性。
这篇综述系统地整合了该领域的最新知识，不仅阐述了各种联合方案的生物学原理，也审视了正在涌现的临床证据。作者团队由Zhou Xiao-Dong、Fan Qiong-Yue、Byrne Christopher D、Targher Giovanni、Muthiah Mark D、Huang Daniel Q、Chen Qin-Fen、Noureddin Mazen、Li Wenhao、Ratziu Vlad、Loomba Rohit、Francque Sven M、Sanyal Arun J和Zheng Ming-Hua等多位国际肝病与代谢领域专家组成。
文章最后指出，合理设计并实施联合疗法是未来MASH管理的重要方向。其最终目标是超越单药治疗的局限，为患者提供在肝脏病理逆转和全身代谢健康改善方面更强大、更持久的解决方案。这为临床医生和研究者提供了一个优化MASH个体化治疗的综合性框架。
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Gut : | Ahead of Print.
10.1136/gutjnl-2025-337431
中国发表（70）
China
Eur J Med Res IF: 03.400Ahead of Print.No.01Sex-specific differences in the prognostic value of METS-IR for long-term outcomes in patients with MASLD and advanced liver fibrosis: a nationwide studyMETS-IR对MASLD合并晚期肝纤维化患者长期预后的预测价值存在性别差异：一项全国性研究DOI: 10.1186/s40001-025-03783-x
Comp Biochem Physiol Part D Genomics Proteomics IF: 02.400Ahead of Print.No.02Comparative transcriptomics identifies key genes and pathways underlying the early skin coloration in leopard coral grouper (Plectropomus leopardus)比较转录组学揭示豹纹珊瑚鳟早期皮肤着色的关键基因与通路DOI: 10.1016/j.cbd.2025.101736
Eur J Med Res IF: 03.400Ahead of Print.No.03Triglyceride glucose index and atherogenic index of plasma predict rapid kidney function decline in cardiovascular-kidney-metabolic syndrome: the first longitudinal evidence from CHARLS甘油三酯-葡萄糖指数与血浆致动脉粥样硬化指数预测心血管-肾脏-代谢综合征患者的肾功能快速下降：来自CHARLS的一项纵向研究证据DOI: 10.1186/s40001-025-03751-5
BMJ open IF: 02.300Volume 15, Issue 12No.04Association between the cumulative average triglyceride glucose-body mass index and glycaemic state transitions in adults with pre-diabetes: evidence from the CHARLS cohort累积平均甘油三酯葡萄糖-体质量指数与成人糖尿病前期患者血糖状态转变的关联：来自CHARLS队列的证据DOI: 10.1136/bmjopen-2025-099014
BMC endocrine disorders IF: 03.300Ahead of Print.No.05New sights of tumor-specific growth factor (TSGF) in T2DM patients with coronary artery disease2型糖尿病合并冠状动脉疾病患者中肿瘤特异性生长因子（TSGF）的新见解DOI: 10.1186/s12902-025-02152-3
Journal of Advanced Research IF: 13.000Ahead of Print.No.06Plasma apolipoprotein E protein attenuates pulmonary fibrosis through LRP1 and PLAU dual receptor-mediated TGF-β/Smad inhibition血浆载脂蛋白E蛋白通过LRP1和PLAU双受体介导的TGF-β/Smad抑制减轻肺纤维化DOI: 10.1016/j.jare.2025.12.045
Journal of controlled release IF: 11.500Ahead of Print.No.07Local cochlear delivery of berberine chloride hydrate via an injectable photo-crosslinked hydrogel for treating diabetes- induced hearing loss通过可注射光交联水凝胶局部递送盐酸小檗碱治疗糖尿病性听力损失DOI: 10.1016/j.jconrel.2025.114582
Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.08Efficacy and safety of finerenone in the treatment of primary aldosteronism: A prospective clinical study非奈利酮治疗原发性醛固酮增多症的有效性与安全性：一项前瞻性临床研究DOI: 10.1016/j.dsx.2025.103369
Colloids Surf B Biointerfaces IF: 05.600Ahead of Print.No.09Cascade ROS-modulating Au/Cu nanozyme hydrogel with nitric oxide release ability for accelerated diabetic foot ulcer healing兼具一氧化氮释放能力的级联ROS调节型金/铜纳米酶水凝胶加速糖尿病足溃疡愈合DOI: 10.1016/j.colsurfb.2025.115403
Colloids Surf B Biointerfaces IF: 05.600Ahead of Print.No.10Baicalein-manganese nanoparticles for antioxidant and osteogenic therapy of bone injury黄芩素-锰纳米颗粒用于骨损伤的抗氧化及成骨治疗DOI: 10.1016/j.colsurfb.2025.115400
Ophthalmology retina IF: 05.700Ahead of Print.No.11Timing of Preoperative Anti-VEGF for Vitrectomy in Proliferative Diabetic Retinopathy: A Competing-Risks Analysis of a Large Cohort增生性糖尿病视网膜病变玻璃体切除术术前抗VEGF用药时机：基于大样本队列的竞争风险分析DOI: 10.1016/j.oret.2025.12.019
Experimental Eye Research IF: 02.700Ahead of Print.No.12Age-related Alterations in Retinal Structure and Blood Perfusion in TIPE2 Gene-Knockout MiceTIPE2基因敲除小鼠视网膜结构与血液灌注的年龄相关改变DOI: 10.1016/j.exer.2025.110834
Gut : IF: 25.800Ahead of Print.No.13Combination therapies for metabolic dysfunction-associated steatohepatitis: challenges and opportunities代谢功能障碍相关脂肪性肝炎的联合疗法：挑战与机遇DOI: 10.1136/gutjnl-2025-337431
Carbohydrate polymers IF: 12.500Volume 375, Issue No.14Structural characterization and lipid-modulating effects of an inulin-type fructan from Bacillus amyloliquefaciens D189: Unraveling the microbiota-gut-liver axis解淀粉芽孢杆菌D189来源的菊粉型果聚糖的结构表征与脂质调节作用：揭示微生物-肠-肝轴机制DOI: 10.1016/j.carbpol.2025.124809
Carbohydrate polymers IF: 12.500Volume 375, Issue No.15Chitosan/selenium nanoparticles Pickering emulsion prolong quercetin retention time to ameliorates cognitive disorder: Focus on restoring the metabolic disorder and gut microbiota壳聚糖/硒纳米颗粒Pickering乳液通过延长槲皮素保留时间改善认知障碍：聚焦于恢复代谢紊乱与肠道菌群DOI: 10.1016/j.carbpol.2025.124804
Carbohydrate polymers IF: 12.500Volume 375, Issue No.16Chitosan and chito-oligosaccharides as multifunctional therapeutics for metabolic dysfunction-associated steatotic liver disease (MASLD)壳聚糖与壳寡糖作为代谢相关脂肪性肝病的多功能疗法DOI: 10.1016/j.carbpol.2025.124737
Journal of affective disorders IF: 04.900Ahead of Print.No.17Sex differences in prevalence of subclinical hypothyroidism and its clinical correlates in overweight or obese, first-episode drug-naïve Chinese patients with major depressive disorder中国超重或肥胖、首次发作未用药重性抑郁障碍患者中亚临床甲状腺功能减退症的患病率及临床相关因素的性别差异DOI: 10.1016/j.jad.2025.121068
Annals of medicine IF: 04.300Volume 58, Issue 1No.18Zinc status following different bariatric procedures: systematic review and meta-analysis不同减重手术后锌水平的系统评价与Meta分析DOI: 10.1080/07853890.2025.2608532
Nutrition IF: 03.000Ahead of Print.No.19Estimating resting metabolic rate in older Chinese adults:A community-based study integrating dietary predictors老年中国人群静息代谢率估算：一项整合膳食预测因子的社区研究DOI: 10.1016/j.nut.2025.113054
JMIR aging IF: 04.800Volume 8, Issue No.20Association of Insulin Resistance, Sarcopenia, and Risk of Cardiovascular Disease: Findings From the China Health and Retirement Longitudinal Study胰岛素抵抗、肌肉减少症与心血管疾病风险的关联：基于中国健康与养老追踪调查的发现DOI: 10.2196/80115
The Journal of cell biology IF: 06.400Volume 225, Issue 2No.21In vivo mapping of peroxisome dynamics and pexophagy using PO-TRG and CA-PO-TRG reporter mice使用PO-TRG及CA-PO-TRG报告小鼠进行体内过氧化物酶体动态及过氧化物酶体自噬（Pexophagy）绘图DOI: 10.1083/jcb.202503169
Biomaterials advances IF: 06.000Ahead of Print.No.22Design, fabrication, and evaluation of antimicrobial sponge-hydrogel bilayer microneedles: An integrated system for transdermal insulin delivery and glucose sensing抗菌海绵-水凝胶双层微针的设计、制备与评估：一个用于透皮胰岛素输送与葡萄糖传感的集成系统DOI: 10.1016/j.bioadv.2025.214693
Medical physics IF: 03.200Volume 53, Issue 1No.23Weakly supervised object detection network for diabetic retinopathy弱监督目标检测网络用于糖尿病视网膜病变检测DOI: 10.1002/mp.70264
Frontiers in nutrition IF: 05.100Volume 12, Issue No.24Correction: Diagnostic efficacy of remnant cholesterol inflammatory index in diabetic kidney disease: machine learning approaches更正：残留胆固醇炎症指数在糖尿病肾病中的诊断有效性：机器学习方法DOI: 10.3389/fnut.2025.1755030
iMeta IF: 33.200Volume 4, Issue 6No.25Single-cell spatial transcriptomics reveals potential molecular mechanisms of Abelmoschus manihot (L.) medic in treating diabetic kidney disease单细胞空间转录组学揭示Abelmoschus manihot (L.) Medic治疗糖尿病肾病的潜在分子机制DOI: 10.1002/imt2.70099
Chinese Medical Journal IF: 07.300Ahead of Print.No.26Association of cardiovascular-kidney-metabolic syndrome stages with mortality: A nationwide, population-based, prospective cohort study心血管-肾脏-代谢综合征分期与死亡率的关联：一项全国性、基于人群的前瞻性队列研究DOI: 10.1097/CM9.0000000000003914
IDCases IF: 01.000Volume 42, Issue No.27Silent pulmonary tuberculosis in patients with poorly controlled diabetes mellitus: Pathogenesis, clinical implications, and diagnostic challenges血糖控制不佳糖尿病患者中的隐匿性肺结核：发病机制、临床意义与诊断挑战DOI: 10.1016/j.idcr.2025.e02357
Frontiers in oncology IF: 03.300Volume 15, Issue No.28Poor nutritional status based on controlling nutritional status score and nutritional risk index may be related to the occurrence of complications after laparoscopic treatment in patients with gastrointestinal tumors aged no more than 60 years基于CONUT评分和NRI的营养不良状态可能与60岁及以下的胃肠道肿瘤患者腹腔镜治疗后并发症的发生有关DOI: 10.3389/fonc.2025.1723703
Frontiers in medicine IF: 03.000Volume 12, Issue No.29Analysis of prognostic prediction and nursing intervention value in PD patients based on nomogram model基于列线图模型对腹膜透析患者预后预测及护理干预价值的分析DOI: 10.3389/fmed.2025.1645631
FCVM IF: 02.900Volume 12, Issue No.30SGLT2 inhibitor short-term efficacy and SYNTAX score association in coronary heart disease retinopathy: a propensity score matching studySGLT2抑制剂短期有效性及SYNTAX评分与冠心病视网膜病变的关联：一项倾向性评分匹配研究DOI: 10.3389/fcvm.2025.1651251
Frontiers in immunology IF: 05.900Volume 16, Issue No.31The multifaceted roles and diagnostic-therapeutic potential of LINC01410 in malignant tumors and non-malignant disordersLINC01410在恶性肿瘤及非恶性疾病中的多维角色与诊疗潜力DOI: 10.3389/fimmu.2025.1588816
J Multidiscip Healthc IF: 02.400Volume 18, Issue No.32Impact of Medical-Prevention Integration on Resource Utilization Efficiency in Chronic Disease Management Among Older Adults: Ethical and Economic Perspectives医防融合模式对老年人慢性病管理资源利用效率的影响：伦理与经济视角DOI: 10.2147/JMDH.S564477
Diabetic medicine IF: 03.400Ahead of Print.No.33The exosome-PI3K/Akt-autophagy axis in diabetic vascular complications: Mechanisms and implications糖尿病血管并发症中的外泌体-PI3K/Akt-自噬轴：机制与意义DOI: 10.1111/dme.70196
Biomed Environ Sci IF: 04.100Volume 38, Issue 12No.34The Impacts of Major Chronic Diseases on Changes in Healthy Life Expectancy among Older Adults in China from 2011 to 20202011-2020年中国老年人主要慢性病对健康预期寿命变化的影响DOI: 10.3967/bes2025.064
Oral diseases IF: 02.900Ahead of Print.No.35Exposure to Famine in Early Childhood Increases the Odds of Edentulism in Adulthood: Results From the China Health and Retirement Longitudinal Study童年早期经历饥荒增加成年后无牙症风险：基于中国健康与养老追踪调查的结果DOI: 10.1111/odi.70177
CCI IF: 01.900Ahead of Print.No.36The Radial Artery Occlusion Paradox: The Larger-Bore Sheath via the Thinner Distal Radial Artery for Coronary Interventional Procedures桡动脉闭塞悖论：经远端桡动脉应用大鞘管行冠状动脉介入治疗DOI: 10.1002/ccd.70456
Microorganisms IF: 04.200Volume 13, Issue 12No.37Alterations in Gut Microbial Co-Abundance Networks in Metabolic Syndrome: A Population-Based Cross-Sectional Study代谢综合征患者肠道微生物共丰度网络的改变：一项基于人群的横断面研究DOI: 10.3390/microorganisms13122759
Ann Agric Environ Med IF: 01.200Volume 32, Issue 4No.38Association between obesity and non-alcoholic fatty liver disease (NAFLD) in adults aged 18 years and above - data from NHANES 2017-201818岁及以上成人中肥胖与非酒精性脂肪性肝病的关联——基于NHANES 2017-2018数据DOI: 10.26444/aaem/210489
Biomed Environ Sci IF: 04.100Volume 38, Issue 12No.39Anthropometric Obesity Measures and Diabetes Progression from Prediabetes in Older Adults: A Comparison of American Diabetes Association and World Health Organization Criteria老年人体质指数及腰围测量与糖尿病前期向糖尿病进展的关系：美国糖尿病协会与世界卫生组织诊断标准的比较DOI: 10.3967/bes2025.090
Biomed Environ Sci IF: 04.100Volume 38, Issue 12No.40Association of Frailty with Mortality and Incident Cardiovascular Disease: The Role of Metabolic Status衰弱与死亡和心血管疾病发病风险的关联：代谢状态的作用DOI: 10.3967/bes2025.154
Biomed Environ Sci IF: 04.100Volume 38, Issue 12No.41Excess Body Weight and Its Influence on Colonoscopy Adherence and Findings: Results from an Opportunistic Colorectal Cancer Screening Program in Chongqing超重对结肠镜筛查依从性及病变检出的影响：来自重庆机会性结直肠癌筛查项目的结果DOI: 10.3967/bes2025.153
Biomed Environ Sci IF: 04.100Volume 38, Issue 12No.42Health Determinants in Association with Cancer Mortality from a Health Ecological Perspective健康生态视角下健康决定因素与癌症死亡率的关系DOI: 10.3967/bes2025.152
Biomed Environ Sci IF: 04.100Volume 38, Issue 12No.43Tackling Adult Obesity in China: A Time for Action应对中国成人肥胖症：行动之时DOI: 10.3967/bes2025.149
Nutrients IF: 05.000Volume 17, Issue 24No.44Hyodeoxycholic Acid Suppresses High-Fat-Diet-Promoted MC38-Syngeneic Colorectal Tumor Growth via Bile Acid Remodeling and Microbiota Modulation猪去氧胆酸通过胆汁酸重塑和肠道菌群调节抑制高脂饮食促进的MC38同源结直肠肿瘤生长DOI: 10.3390/nu17243939
Nutrients IF: 05.000Volume 17, Issue 24No.45Soluble Dietary Fiber from Highland Barley Bran Reduces Hepatic Lipid Accumulation in Mice via Gut Microbiota Modulation青稞麸皮可溶性膳食纤维通过调控肠道菌群减少小鼠肝脏脂质积累DOI: 10.3390/nu17243870
Population health metrics IF: 02.500Ahead of Print.No.46Association of loneliness and social isolation with excess risk of mental disorders in people with obesity: a prospective cohort study肥胖人群中孤独与社交隔离与精神障碍超额风险的关联：一项前瞻性队列研究DOI: 10.1186/s12963-025-00451-4
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.47Development and external validation of machine-learning based models to predict diabetic foot ulcer in diabetes population基于机器学习的糖尿病足溃疡预测模型的开发与外部验证DOI: 10.3389/fendo.2025.1692917
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.48Exploring the mechanism of Heidihuang Pill in the treatment of osteoporosis based on network pharmacology, molecular docking, and experimental validation基于网络药理学、分子对接及实验验证探讨黑地黄丸治疗骨质疏松的作用机制DOI: 10.3389/fendo.2025.1664254
Journal of nanobiotechnology IF: 12.600Ahead of Print.No.49Biomimetic cell membrane decorated calcium carbonate nanoparticles with asparaginase-metformin preloading for leukemia therapy载有天冬酰胺酶-二甲双胍的仿生细胞膜修饰碳酸钙纳米颗粒用于白血病治疗DOI: 10.1186/s12951-025-03962-2
Frontiers in neurology IF: 02.800Volume 16, Issue No.50Comparative impact of different weight loss strategies on obstructive sleep apnea: an integrated review of surgical, pharmacological, and lifestyle interventions不同减肥策略对阻塞性睡眠呼吸暂停影响的比较综述：手术、药物和生活方式干预DOI: 10.3389/fneur.2025.1719923
Molecules IF: 04.600Volume 30, Issue 24No.51Discovery and Activity Evaluation of Novel Dibenzoxazepinone Derivatives as Glycogen Phosphorylase Inhibitors新型二苯并氧氮杂䓬酮衍生物作为糖原磷酸化酶抑制剂的发现与活性评价DOI: 10.3390/molecules30244797
Molecules IF: 04.600Volume 30, Issue 24No.52Isolation, Total Synthesis and Anti-Diabetic Activity of Filiforidine from Cassytha filiformis从无根藤中分离、全合成菲力福里定及其抗糖尿病活性研究DOI: 10.3390/molecules30244763
Nutrients IF: 05.000Volume 17, Issue 24No.53Impact of the Mediterranean Diet on Glycemic Control, Body Mass Index, Lipid Profile, and Blood Pressure in Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials地中海饮食对2型糖尿病患者血糖控制、体重指数、血脂谱及血压影响的荟萃分析DOI: 10.3390/nu17243908
Frontiers in medicine IF: 03.000Volume 12, Issue No.54The impact of short-term administration of dapagliflozin on contrast-induced acute kidney injury in patients with type 2 diabetes and renal insufficiency undergoing percutaneous coronary intervention短期应用达格列净对合并肾功能不全的2型糖尿病患者经皮冠状动脉介入治疗后造影剂急性肾损伤的影响DOI: 10.3389/fmed.2025.1744473
J Clin Transl Hepatol IF: 04.200Volume 13, Issue 12No.55Quality and Quantity? The Clinical Significance of Myosteatosis in Various Liver Diseases: A Narrative Review质量还是数量？肌脂变在各种肝病中的临床意义：一篇叙述性综述DOI: 10.14218/JCTH.2025.00383
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.56Effects of fecal microbiota transplantation on glycemic and lipid profiles in overweight or obese patients with metabolic disorders: a systematic review and meta-analysis粪菌移植对超重或肥胖代谢紊乱患者血糖及血脂谱影响：一项系统评价与荟萃分析DOI: 10.3389/fendo.2025.1737543
Frontiers in microbiology IF: 04.500Volume 16, Issue No.57Gut microbiome associated with melanin deposition by supporting energy metabolism in Sichuan mountainous black-bone chickens肠道微生物组通过支持能量代谢影响四川山地乌骨鸡的黑色素沉积DOI: 10.3389/fmicb.2025.1682376
Microorganisms IF: 04.200Volume 13, Issue 12No.58Shared Gut Microbial and Functional Signatures Linking Parkinson's Disease and Type 2 Diabetes Revealed by Function-Anchored Metagenomics基于功能锚定的宏基因组学揭示连接帕金森病与2型糖尿病的共享肠道微生物及功能特征DOI: 10.3390/microorganisms13122705
Molecules IF: 04.600Volume 30, Issue 24No.59First In Vitro Human Islet Assessment of Oleanolic Acid (OA) and Its Serine Conjugate: Enhanced Solubility with Comparable Effects齐墩果酸及其丝氨酸结合物的首次体外人类胰岛评估：溶解性增强且效果相当DOI: 10.3390/molecules30244716
Pharmaceuticals IF: 04.800Volume 18, Issue 12No.60Berberine: A Rising Star in the Management of Type 2 Diabetes-Novel Insights into Its Anti-Inflammatory, Metabolic, and Epigenetic Mechanisms小檗碱：2型糖尿病管理中的一颗新星——其抗炎、代谢与表观遗传机制的新见解DOI: 10.3390/ph18121890
Pharmaceuticals IF: 04.800Volume 18, Issue 12No.61Emodin Enhances Rosiglitazone's Therapeutic Profile by Dual Modulation of SREBP1-Mediated Adipogenesis and PPARγ-Driven Thermogenesis大黄素通过双重调节SREBP1介导的脂肪生成与PPARγ驱动的产热作用增强罗格列酮的治疗谱DOI: 10.3390/ph18121810
Pharmaceutics IF: 05.500Volume 17, Issue 12No.62The Detrimental Effects of Crystalline Excipients: How They Jeopardize the Long-Term Stability of Freeze-Dried Polypeptide Formulations结晶性辅料的不利影响：它们如何损害冻干多肽制剂的长期稳定性DOI: 10.3390/pharmaceutics17121543
Nutrients IF: 05.000Volume 17, Issue 24No.63European Bilberry Extract Ameliorates Dietary Advanced Glycation End Products-Induced Non-Alcoholic Steatohepatitis in Rats via Gut Microbiota and Its Metabolites欧洲越橘提取物通过肠道菌群及其代谢物改善饮食晚期糖基化终末产物诱导的大鼠非酒精性脂肪性肝炎DOI: 10.3390/nu17243918
Nutrients IF: 05.000Volume 17, Issue 24No.64Milk Powder Fortified with Folic Acid and Colostrum Basic Protein Promotes Linear Growth and Improves Bone Microarchitecture in Juvenile Mice Without Adverse Metabolic Effects添加叶酸和初乳碱性蛋白的奶粉促进幼年小鼠线性生长并改善骨微结构，且无不良代谢影响DOI: 10.3390/nu17243819
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.65Comparison of different insulin resistance surrogates in predicting hyperuricemia in non-diabetic Yi residents in Yunnan Province云南非糖尿病人群中不同胰岛素抵抗替代指标预测高尿酸血症能力的比较DOI: 10.3389/fendo.2025.1523771
Int J Gen Med IF: 02.000Volume 18, Issue No.66Correlation Between Triglyceride-Glucose Index (TyG Index), Monocyte to High-Density Lipoprotein Cholesterol Ratio (MHR), and the Severity of Coronary Artery Disease甘油三酯-葡萄糖指数（TyG指数）、单核细胞与高密度脂蛋白胆固醇比值（MHR）与冠状动脉疾病严重程度的相关性DOI: 10.2147/IJGM.S570395
Lipids in health and disease IF: 04.200Ahead of Print.No.67Comparison of the TyG index, TyG-traditional obesity indices, and TyG-novel obesity indices: does increased complexity help in predicting cardiometabolic multimorbidity?比较TyG指数、TyG-传统肥胖指数与TyG-新型肥胖指数：增加复杂性有助于预测心脏代谢多病吗？DOI: 10.1186/s12944-025-02836-8
Nutrients IF: 05.000Volume 17, Issue 24No.68Pioneering Insights into the Complexities of Salt-Sensitive Hypertension: Central Nervous System Mechanisms and Dietary Bioactive Compound Interventions盐敏感性高血压的复杂机制探索：中枢神经系统通路与膳食生物活性化合物干预的新见解DOI: 10.3390/nu17243961
FCVM IF: 02.900Volume 12, Issue No.69Effects of subcutaneous or oral semaglutide on cardiovascular outcomes in patients with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials皮下或口服司美格鲁肽对2型糖尿病患者心血管结局的影响：随机对照试验的荟萃分析DOI: 10.3389/fcvm.2025.1731127
J Transl Med IF: 07.500Volume 23, Issue 1No.70Comment on: "Identification of macrophage polarisation and mitochondrial-related biomarkers in diabetic retinopathy"糖尿病视网膜病变中巨噬细胞极化及线粒体相关生物标志物的识别DOI: 10.1186/s12967-025-07457-4
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Legal medicine IF: 01.400Ahead of Print.No.01Application of RNA sequencing to cause-of-death investigation: A pilot studyRNA测序在死因调查中的应用：一项初步研究DOI: 10.1016/j.legalmed.2025.102772
Scientific reports IF: 03.900Ahead of Print.No.02Understanding the mechanism of Crassocephalum crepidiodes (Benth.) S. Moore leaf antifibrotic activity using in vivo and in silico methods基于体内外方法探究Crassocephalum crepidiodes (Benth.) S. Moore叶抗纤维化活性的机制DOI: 10.1038/s41598-025-34489-z
Virology journal IF: 03.800Ahead of Print.No.03SGLT2 inhibitors prevent long-COVID-associated cognitive and pain symptoms in type 2 diabetes patientsSGLT2抑制剂预防2型糖尿病患者长期COVID相关的认知和疼痛症状DOI: 10.1186/s12985-025-03054-5
Scientific reports IF: 03.900Ahead of Print.No.04Analysis of proteins and peptides to investigate the molecular signatures of a conventional antidiabetic herb, Boerhavia procumbens Banks ex Roxb. (Nyctaginaceae)通过分析蛋白质与肽段探究传统抗糖尿病草药Boerhavia procumbens Banks ex Roxb. (Nyctaginaceae)的分子特征DOI: 10.1038/s41598-025-16474-8
BMJ case reports IF: 00.500Volume 18, Issue 12No.05Concurrent hepatic adenomatosis and hemangiomatosis in a patient with HNF1A MODYHNF1A MODY患者并发肝腺瘤病与血管瘤病DOI: 10.1136/bcr-2025-269815
BMJ case reports IF: 00.500Volume 18, Issue 12No.06Miliary tuberculosis with hypercalcaemia-induced nephrogenic diabetes insipidus in an infant婴儿粟粒性结核伴高钙血症诱发肾性尿崩症DOI: 10.1136/bcr-2025-269609
BMJ open IF: 02.300Volume 15, Issue 12No.07Implementation of the community health system innovation project in three low- and middle-income countries: COHESION-I study protocol社区健康系统创新项目在三个低收入和中等收入国家的实施：COHESION-I研究方案DOI: 10.1136/bmjopen-2025-109433
Endocrine practice IF: 04.600Ahead of Print.No.08LOW VASOPRESSIN IN MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME肌痛性脑脊髓炎/慢性疲劳综合征中的低血管加压素水平DOI: 10.1016/j.eprac.2025.12.020
J Biomed Inform IF: 04.500Ahead of Print.No.09Integrating retrospective quality assessment with real-time guideline application to support the episodic application of clinical guidelines over significant time periods集成回顾性质控与实时指南应用以支持临床指南在较长时间内的阶段性应用DOI: 10.1016/j.jbi.2025.104975
Journal of affective disorders IF: 04.900Ahead of Print.No.10Weight control methods and risk of generalized anxiety disorder (GAD-7) among Korean adults韩国成人减肥方法与广泛性焦虑障碍（GAD-7）风险的关系DOI: 10.1016/j.jad.2025.121071
Am J Clin Nutr IF: 06.900Ahead of Print.No.11Consuming an unprocessed diet reduces energy intake: A post-hoc analysis of an RCT reveals a role for human 'nutritional intelligence'摄入非加工饮食可减少能量摄入：一项随机对照试验的事后分析揭示人类“营养智能”的作用DOI: 10.1016/j.ajcnut.2025.101183
Canadian journal of diabetes IF: 02.600Ahead of Print.No.12Evaluating virtual care for diabetes during the COVID-19 pandemic: results from a pre-post retrospective cohort pilot study in a Canadian family health teamCOVID-19大流行期间糖尿病虚拟护理评估：一项加拿大家庭健康团队预-后回顾性队列试点研究结果DOI: 10.1016/j.jcjd.2025.12.010
Canadian journal of diabetes IF: 02.600Ahead of Print.No.13Diabetes Self-Care in Daily Life: a Qualitative Study on Goal Conflict Management in Emerging Adults With Type 1 Diabetes1型糖尿病年轻成人的日常自我管理：关于目标冲突管理的定性研究DOI: 10.1016/j.jcjd.2025.12.011
Psychiatry research IF: 03.900Ahead of Print.No.14Metabolic monitoring and control among patients with type 2 diabetes prescribed second generation antipsychotics接受第二代抗精神病药物治疗的2型糖尿病患者的代谢监测与控制DOI: 10.1016/j.psychres.2025.116925
Placenta IF: 02.500Ahead of Print.No.15Exploring the role of specialized pro-resolving mediators, fatty acid oxidation markers and transporters in Gestational Diabetes Mellitus (GDM) placentae探究特异性促消退介质、脂肪酸氧化标志物及转运蛋白在妊娠期糖尿病胎盘中的作用DOI: 10.1016/j.placenta.2025.12.014
Sleep medicine IF: 03.400Ahead of Print.No.16Exploring sleep outcomes in youth across settings: Are there differences based on rurality or medically underserved status in the ECHO cohort?探索不同环境下青少年的睡眠状况：基于农村或医疗服务不足状况在ECHO队列中是否存在差异？DOI: 10.1016/j.sleep.2025.108754
Tissue & cell IF: 02.500Ahead of Print.No.17Vitreous exosomes and ocular regeneration: Emerging roles in intercellular communication, biomarkers, and therapeutic delivery玻璃体外泌体与眼再生：细胞间通讯、生物标志物及治疗递送中的新兴作用DOI: 10.1016/j.tice.2025.103300
Ophthalmology IF: 09.500Ahead of Print.No.18Cardiovascular Risk and Eye Health: A Prospective Cohort Study of the Pooled Cohort Equations and Ocular Disease Incidence心血管风险与眼部健康：一项关于汇总队列方程与眼部疾病发病率的前瞻性队列研究DOI: 10.1016/j.ophtha.2025.12.021
J Diabetes Complications IF: 03.100Ahead of Print.No.19Effects of high estimated glomerular filtration rate on kidney prognosis in individuals with type 2 diabetes高估测肾小球滤过率对2型糖尿病患者肾脏预后的影响DOI: 10.1016/j.jdiacomp.2025.109255
Am J Ophthalmol IF: 04.200Ahead of Print.No.20Comment on: Glucagon-like Peptide-1 Receptor Agonist Use and Risk of Cataract Development评论：胰高血糖素样肽-1受体激动剂使用与白内障发生风险DOI: 10.1016/j.ajo.2025.11.050
Biology of sex differences IF: 05.100Ahead of Print.No.21Hormones, heat, and health: a comprehensive review of sex-based differences in brown and beige fat biology激素、热量与健康：棕色脂肪与米色脂肪生物学中基于性别差异的全面评述DOI: 10.1186/s13293-025-00787-4
Nature communications IF: 15.700Ahead of Print.No.22Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator老年胰岛素抵抗骨骼的磷酸蛋白质组学鉴定出P70S6K对AFF4的磷酸化是一种基因特异性转录调节因子DOI: 10.1038/s41467-025-68106-4
Surg Obes Relat Dis IF: 03.800Ahead of Print.No.23The impact of hospital volume on metabolic and bariatric surgery outcomes医院手术量对代谢与减重手术结果的影响DOI: 10.1016/j.soard.2025.11.023
BMJ case reports IF: 00.500Volume 18, Issue 12No.24Delayed retrograde jejunogastric intussusception after Roux-en-Y gastrojejunostomy: an uncommon complication in an unexpected anatomyRoux-en-Y胃空肠吻合术后迟发性逆行性空肠胃套叠：一种意外解剖结构中的罕见并发症DOI: 10.1136/bcr-2025-268432
BMJ open IF: 02.300Volume 15, Issue 12No.25Impact of food accessibility on eating and anthropometric outcomes among rural parent-child dyads: a secondary data analysis of a mindful eating intervention食物可及性对农村亲子对的饮食行为和人体测量学结果的影响：一项正念饮食干预的二次数据分析DOI: 10.1136/bmjopen-2025-108076
Am J Clin Nutr IF: 06.900Ahead of Print.No.26Diet quality and nutritional adequacy during a 2-year calorie restriction intervention: the CALERIE™ 2 trial为期两年的热量限制干预期间的饮食质量与营养充足性：CALERIE™ 2试验DOI: 10.1016/j.ajcnut.2025.101182
Ophthalmology IF: 09.500Ahead of Print.No.27Rate and risk of non-arteritic anterior ischaemic optic neuropathy with semaglutide use for diabetes and weight loss: a systematic review and meta-analysis司美格鲁肽用于糖尿病和减重时的非动脉炎性前部缺血性视神经病变发生率和风险：一项系统评价与荟萃分析DOI: 10.1016/j.ophtha.2025.12.022
J Sport Health Sci IF: 10.300Ahead of Print.No.28A systematic review and meta-analyses of the relationships between active outdoor play and 24-hour movement behaviors关于主动户外游戏与24小时运动行为关系的系统综述和荟萃分析DOI: 10.1016/j.jshs.2025.101115
Pharmacological research IF: 10.500Ahead of Print.No.29Low, non-psychedelic doses of psilocybin as a novel treatment for MASLD, obesity and Type 2 Diabetes via 5-HT2B receptor-dependent mechanisms低剂量、非致幻的赛洛西宾通过5-HT2B受体依赖机制成为治疗MASLD、肥胖和2型糖尿病的新方法DOI: 10.1016/j.phrs.2025.108080
J Nutr Biochem IF: 04.900Ahead of Print.No.30Complementary mechanisms of high-carbohydrate diets and ketogenic diets restore adult hippocampal neurogenesis and cognitive function in high-fat diet induced obesity in mice高碳水化合物饮食与生酮饮食通过互补机制恢复高脂饮食诱导的肥胖小鼠成年海马神经发生与认知功能DOI: 10.1016/j.jnutbio.2025.110245
Clinical nutrition ESPEN IF: 02.600Ahead of Print.No.31BODY COMPOSITION AND FUNCTIONAL STATUS IN THE COVID-19 RECOVERY PHASE: PREVALENCE OF SARCOPENIA AND SARCOPENIC OBESITYCOVID-19恢复期的身体成分与功能状态：肌肉减少症与肌肉减少性肥胖的患病率DOI: 10.1016/j.clnesp.2025.102877
Clinical nutrition ESPEN IF: 02.600Ahead of Print.No.32Can the (13)C-octanoic acid breath test accurately measure gastric emptying after sleeve gastrectomy and Roux-en-Y gastric bypass? A proof-of concept analysis碳13-辛酸呼气试验能否准确测量袖状胃切除和Roux-en-Y胃旁路术后的胃排空？一项概念验证分析DOI: 10.1016/j.clnesp.2025.102891
Nutrition IF: 03.000Ahead of Print.No.33Comparing body composition techniques against an adapted multicompartment model in individuals with excess body weight不同体成分测量技术与改良多室模型在超重个体中的比较DOI: 10.1016/j.nut.2025.113033
Biochem Biophys Res Commun IF: 02.200Ahead of Print.No.34Quinones as promising agents for managing metabolic syndrome: Therapeutic and toxicological considerations醌类作为管理代谢综合征的潜力药物：治疗与毒理考量DOI: 10.1016/j.bbrc.2025.153221
Food chemistry IF: 09.800Ahead of Print.No.35Selenium-enriched chickpea beverage powders: How particle size shapes composition and functionality富硒鹰嘴豆饮料粉：粒径如何影响其成分与功能特性DOI: 10.1016/j.foodchem.2025.147692
Scientific reports IF: 03.900Volume 15, Issue 1No.36Drug-related hepatotoxicity risk in elderly patients with atrial fibrillation: insights from the nationwide Italian START registry老年心房颤动患者的药物相关性肝毒性风险：基于意大利全国性START注册研究的见解DOI: 10.1038/s41598-025-28502-8
BMJ case reports IF: 00.500Volume 18, Issue 12No.37Skull base osteomyelitis following Klebsiella pneumoniae meningitis in an immunocompromised host免疫功能低下宿主克雷伯菌肺炎链球菌脑膜炎后继发颅底骨髓炎DOI: 10.1136/bcr-2025-267719
J Atheroscler Thromb IF: 02.800Volume 33, Issue 1, Page 1-115No.38High-Sensitivity C-Reactive Protein and Residual Inflammatory Risk in Coronary Artery Disease: The Pathophysiology, Prognosis, and Emerging Therapies高敏C反应蛋白与冠状动脉疾病的残余炎症风险：病理生理、预后与新兴疗法DOI: 10.5551/jat.RV22044
J Atheroscler Thromb IF: 02.800Volume 33, Issue 1, Page 1-115No.39Critical Role of microRNA-33a/b in Cardiovascular and Metabolic Disease: Molecular Mechanisms and Therapeutic PerspectivesMicroRNA-33a/b在心血管与代谢疾病中的关键作用：分子机制与治疗前景DOI: 10.5551/jat.RV22045
Mymensingh medical journalVolume 35, Issue 1No.40Relationship between Body Mass Index and Dengue Severity in Hospitalized Adults: Evidence from Bangladesh住院成人患者体重指数与登革热严重程度的关系：来自孟加拉国的证据https://pubmed.ncbi.nlm.nih.gov/41474892
Mymensingh medical journalVolume 35, Issue 1No.41Klumpke's Palsy Following Minor Trauma: A Rare Presentation in a Young Adult轻微创伤后出现克隆普克麻痹：一名年轻成人的罕见病例https://pubmed.ncbi.nlm.nih.gov/41474925
American journal of nephrology IF: 03.200Ahead of Print.No.42Triglyceride-glucose index, systolic blood pressure and risk of tubular atrophy/interstitial fibrosis in IgA nephropathyIgA肾病患者中甘油三酯-葡萄糖指数、收缩压与肾小管萎缩/间质纤维化风险DOI: 10.1159/000550298
JMIR formative research IF: 02.100Volume 9, Issue No.43Prescribing Experiences, Potentials, and Challenges of Digital Health Applications in the Field of Hormones and Metabolism: Cross-Sectional Survey Study of Health Care Providers in Germany激素与代谢领域数字健康应用的处方经验、潜力与挑战：德国医疗保健提供者横断面调查研究DOI: 10.2196/77792
JMIR Cardio IF: 02.200Volume 9, Issue No.44Predicting Atrial Fibrillation Ablation Outcomes: Machine Learning Model Development and Validation Using a Large Administrative Claims Database预测心房颤动消融结局：基于大型行政索赔数据库的机器学习模型开发与验证DOI: 10.2196/77380
Inform Health Soc Care IF: 02.400Ahead of Print.No.45Predicting the diabetes risk by analyzing symptoms using data mining techniques运用数据挖掘技术通过症状分析预测糖尿病风险DOI: 10.1080/17538157.2025.2602517
Mymensingh medical journalVolume 35, Issue 1No.46Association of Acidosis and Inflammation with Low Serum Albumin in CKD Stages 3-5 Predialysis PatientsCKD 3-5期透析前患者酸中毒和炎症与低血清白蛋白的关联https://pubmed.ncbi.nlm.nih.gov/41474916
Mymensingh medical journalVolume 35, Issue 1No.47Association of Serum Vitamin D Status with Gestational Diabetes Mellitus: An Experience from a Tertiary Level Specialized Diabetic Hospital in Bangladesh血清维生素D状态与妊娠期糖尿病相关性的研究：来自孟加拉国一家三级专科糖尿病医院的经验https://pubmed.ncbi.nlm.nih.gov/41474908
Mymensingh medical journalVolume 35, Issue 1No.48Identification of Causes and Diagnostic Difficulty in Managing Paediatric Pancreatitis: Experience at A Tertiary Care Center of Resource-Constraint Country资源有限国家三级医疗中心管理经验：儿科胰腺炎的病因识别与诊断困境https://pubmed.ncbi.nlm.nih.gov/41474905
Mymensingh medical journalVolume 35, Issue 1No.49Trimetazidine Ameliorates Progression of Diabetic Nephropathy by Reducing Serum Creatinine Level in Streptozotocin Induced Diabetic Rats曲美他嗪通过降低链脲佐菌素诱导的糖尿病大鼠血清肌酐水平改善糖尿病肾病进展https://pubmed.ncbi.nlm.nih.gov/41474898
Mymensingh medical journalVolume 35, Issue 1No.50Prescribing Pattern of Oral Anti-diabetic Agents among Patients with Type 2 Diabetes in Outpatient Department of a Tertiary Care Hospital in Bangladesh孟加拉国某三级医院门诊2型糖尿病患者口服降糖药物的处方模式https://pubmed.ncbi.nlm.nih.gov/41474893
Mymensingh medical journalVolume 35, Issue 1No.51Assessment of Serum Ferritin in Patients with Type 2 Diabetes Mellitus评估2型糖尿病患者血清铁蛋白水平https://pubmed.ncbi.nlm.nih.gov/41474891
Mymensingh medical journalVolume 35, Issue 1No.52Association of Glycemic Gap with In-Hospital Adverse Outcome after First Attack of Acute ST Elevation Myocardial Infarction in Thrombolysed Patients血糖间隙与接受溶栓治疗的急性ST段抬高型心肌梗死患者院内不良结局的关联https://pubmed.ncbi.nlm.nih.gov/41474890
Mymensingh medical journalVolume 35, Issue 1No.53Medial Plantar Artery Flap for Heel Reconstruction: A Retrospective Observational Study足跟重建的足底内侧动脉皮瓣：一项回顾性观察研究https://pubmed.ncbi.nlm.nih.gov/41474889
PloS one IF: 02.600Volume 20, Issue 12No.54Clinical and social determinants of cardiovascular risk in a population with chronic noncommunicable diseases in Maicao, La Guajira, Colombia: 2024哥伦比亚拉瓜希拉省迈考地区慢性非传染性疾病人群心血管风险的临床与社会决定因素：2024年研究DOI: 10.1371/journal.pone.0340101
PloS one IF: 02.600Volume 20, Issue 12No.55Trixis angustifolia DC. as a potential plant for the co-management of diabetes mellitus and tuberculosisTrixis angustifolia DC.作为糖尿病与肺结核共管的潜在药用植物DOI: 10.1371/journal.pone.0339176
PloS one IF: 02.600Volume 20, Issue 12No.56The Peak Plasma Concentration (Cmax)/Minimum Inhibitory Concentration (MIC) of bedaquiline and levofloxacin with special attention to the sputum conversion in the treatment of multidrug-resistant tuberculosis in Indonesia贝达喹啉和左氧氟沙星的峰浓度/最低抑菌浓度 (Cmax/MIC) 与印度尼西亚多重耐药肺结核治疗中痰培养阴转关系的研究DOI: 10.1371/journal.pone.0336210
PloS one IF: 02.600Volume 20, Issue 12No.57Stepping forward: A study protocol for developing and validating a Malaysian diabetic foot self-care practice assessment instrument迈步向前：一项用于开发和验证马来西亚糖尿病足自我护理实践评估工具的研究方案DOI: 10.1371/journal.pone.0337754
J Am Podiatr Med Assoc IF: 00.600Volume 115, Issue 6No.58Associations of Diabetic Foot Infection with Ulcer Prognosis and Amputation Timing in Patients with Type 2 Diabetes Mellitus2型糖尿病患者足部感染与溃疡预后及截肢时机的关联DOI: 10.7547/23-230
J Am Podiatr Med Assoc IF: 00.600Volume 115, Issue 6No.59Impact of COVID-19 Pandemic on Diabetic Foot Ulcer Management in Kalamazoo, MichiganCOVID-19大流行对美国密歇根州卡拉马祖地区糖尿病足溃疡管理的影响DOI: 10.7547/24-036
J Am Podiatr Med Assoc IF: 00.600Volume 115, Issue 6No.60Canines Masticating on the Lower Extremity犬只啃食糖尿病患者足部/趾部：现象与警示DOI: 10.7547/24-071
Journal of glaucoma IF: 01.800Ahead of Print.No.61Surgical Outcomes of Ahmed Glaucoma Valve in Neovascular Glaucoma Secondary to Diabetic Retinopathy Versus Central Retinal Vein OcclusionAhmed青光眼引流阀在糖尿病视网膜病变与视网膜中央静脉阻塞所致新生血管性青光眼中的手术结局比较DOI: 10.1097/IJG.0000000000002680
PloS one IF: 02.600Volume 20, Issue 12No.62Correction: FedGAN: Federated diabetic retinopathy image generation更正：FedGAN：联邦糖尿病视网膜病变图像生成DOI: 10.1371/journal.pone.0340003
J Clin Exp Neuropsychol IF: 01.700Ahead of Print.No.63Conversion of subjective cognitive decline to MCI and dementia: a systematic review and meta-analysis of sex differences and risk factors主观认知下降向轻度认知障碍及痴呆的转化：性别差异与风险因素的系统综述和荟萃分析DOI: 10.1080/13803395.2025.2609824
Arch Gynecol Obstet IF: 02.500Volume 313, Issue 1No.64Antepartum prediction of shoulder dystocia using machine learning应用机器学习进行产前肩难产预测DOI: 10.1007/s00404-025-08271-5
The journal of physiology IF: 04.400Ahead of Print.No.65Kidney disease impairs tendon function in rats肾病损害大鼠肌腱功能DOI: 10.1113/JP289753
Epilepsia IF: 06.600Ahead of Print.No.66Drug-resistant glutamic acid decarboxylase 65-associated epilepsy: Pre-surgical evaluation and comparison to temporal lobe epilepsy of other etiology药物难治性谷氨酸脱羧酶65相关癫痫的术前评估及与其他病因颞叶癫痫的比较DOI: 10.1002/epi.70068
Annals of African medicine IF: 00.600Ahead of Print.No.67Repeated Multiple Episodes of Furunculosis in a Young Brittle Diabetic, Successfully Treated一例年轻脆性糖尿病患者反复多发疖病的成功治疗DOI: 10.4103/aam.aam_566_25
Postgraduate medical journal IF: 02.700Ahead of Print.No.68Pharmacogenetics of incretin-based therapies基于肠促胰素疗法的药物遗传学DOI: 10.1093/postmj/qgaf232
Diabetic medicine IF: 03.400Ahead of Print.No.69Progression of albumin/creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR) over 24 years in people with type 2 diabetes. Drivers, potential protectors and associated mortality2型糖尿病患者24年间尿白蛋白/肌酐比值（ACR）和估算肾小球滤过率（eGFR）的进展：驱动因素、潜在保护因素及相关死亡率DOI: 10.1111/dme.70193
Small IF: 12.100Ahead of Print.No.703D-Printed Auxetic Hydrogel Dressings Reinforced With MXene and Carbonized Polymer Dots for Cascaded Antibacterial and Pro-Regenerative Effects in Wound Healing3D打印含MXene和碳化聚合物点的拉胀水凝胶敷料用于伤口愈合中的级联抗菌和促再生效应DOI: 10.1002/smll.202508633
eLifeVolume 13, Issue No.71JAK-STAT pathway activation compromises nephrocyte function in a Drosophila high-fat diet model of chronic kidney diseaseJAK-STAT通路激活损害果蝇高脂饮食慢性肾脏病模型中的肾细胞功能DOI: 10.7554/eLife.96987
J Diabetes Investig IF: 03.000Ahead of Print.No.72The biology of PKM2 in the metabolism and senescence in diabetic kidney diseasePKM2在糖尿病肾病代谢与衰老中的生物学作用DOI: 10.1111/jdi.70231
Arch Gynecol Obstet IF: 02.500Volume 313, Issue 1No.73The outcomes of pregnancy after metabolic and bariatric surgery: a literature review代谢与减重手术后妊娠结局：一项文献综述DOI: 10.1007/s00404-025-08290-2
Lung India IF: 01.200Volume 43, Issue 1No.74Impact of metabolically healthy and metabolically unhealthy obesity on cardiac arrest and mortality in pulmonary embolism hospitalizations in elderly patients with cancer代谢健康与代谢不健康肥胖对老年癌症患者肺栓塞住院期间心脏骤停及死亡率的影响DOI: 10.4103/lungindia.lungindia_134_25
Hepatology research IF: 03.400Ahead of Print.No.75Post-COVID-19 Changes in Body Composition and Adiposity in Patients With Chronic Liver Disease: A Longitudinal Study From Japan慢性肝病患者在COVID-19后身体成分与肥胖状态的变化：一项来自日本的纵向研究DOI: 10.1111/hepr.70114
J Clin Pharmacol IF: 02.300Volume 66, Issue 1No.76Population Pharmacokinetics to Support Intravenous and Enteral Methadone Dosing in Children基于群体药代动力学优化儿童静脉及肠内美沙酮给药方案DOI: 10.1002/jcph.70143
The journal of physiology IF: 04.400Ahead of Print.No.77First in-human microelectrode recordings of vagus nerve activity in heart failure心力衰竭患者迷走神经活动的微电极记录DOI: 10.1113/JP290343
Journal of periodontology IF: 03.800Ahead of Print.No.78Hyperglycemia exacerbates placental inflammation induced by Porphyromonas gingivalis-lipopolysaccharide高血糖加剧由牙龈卟啉单胞菌脂多糖诱导的胎盘炎症DOI: 10.1002/jper.70051
Diabetes care IF: 16.600Ahead of Print.No.79Metabolic Factors Modulating the Connection Between Diabetes and Pulmonary Alterations调控糖尿病与肺部改变关联的代谢因素DOI: 10.2337/dc25-2334
Computers, informatics, nursing IF: 01.900Ahead of Print.No.80A Digital Diabetes Clinic Intervention for Individuals Starting Insulin Therapy: Randomized Controlled Trial针对起始胰岛素治疗个体的数字糖尿病诊所干预：一项随机对照试验DOI: 10.1097/CIN.0000000000001439
Lung India IF: 01.200Volume 43, Issue 1No.81Burden and impact of pulmonary embolism in young adults hospitalized with sarcoidosis: Underreported data from nationwide analysis (2016-2020)住院年轻成人结节病患者中肺栓塞的负担与影响：来自全国性分析（2016-2020年）的未被充分报告的数据DOI: 10.4103/lungindia.lungindia_375_25
BMC Sports Sci Med Rehabil IF: 02.800Volume 17, Issue 1No.82Acute hematological, metabolic, and inflammatory responses to simulated-6000 ft masked versus unmasked high-intensity interval training in youth soccer players: a randomized crossover pilot study青少年足球运动员对模拟6000英尺海拔训练面罩与无面罩高强度间歇训练的急性血液学、代谢和炎症反应：一项随机交叉试验研究DOI: 10.1186/s13102-025-01426-6
Medicina IF: 02.400Volume 61, Issue 12No.83Dysregulation of Niacin-Derived NAD(+) Salvage Pathway Markers (CD38, NAMPT, SIRT1) Across Albuminuria Stages in Type 2 Diabetes2型糖尿病中烟酰胺来源的NAD+补救途径标志物（CD38、NAMPT、SIRT1）在白蛋白尿各阶段的失调DOI: 10.3390/medicina61122089
Curēus IF: 01.300Volume 17, Issue 12No.84Morbidity in Elderly Women Undergoing Pelvic Floor Reconstruction老年女性接受盆底重建术的围手术期发病率研究DOI: 10.7759/cureus.100361
American journal of medicine openVolume 14, Issue No.85GLP-1 Receptor Agonists Initiation and Risk of Acute Pancreatitis and Pancreatic Cancer: A Real-World Comparative StudyGLP-1受体激动剂起始治疗与急性胰腺炎及胰腺癌风险：一项真实世界比较研究DOI: 10.1016/j.ajmo.2025.100114
Rev Panam Salud Publica IF: 02.200Volume 49, Issue No.86[Situation of essential conditions for the delivery of care for noncommunicable diseases in the Bolivian Chaco regionSituação das condições essenciais para a atenção a doenças não transmissíveis na região do Chaco boliviano]玻利维亚查科地区非传染性疾病护理基本条件的现状评估DOI: 10.26633/RPSP.2025.135
Clinical case reports IF: 00.600Volume 14, Issue 1No.87An Epileptic Girl With Erotomania Using Carbamazepine|Resistant to Treatment and Challenge of Starting Clozapine一名使用卡马西平的癫痫伴钟情妄想女性患者：治疗抵抗与启用氯氮平的挑战DOI: 10.1002/ccr3.71741
Frontiers in public health IF: 03.400Volume 13, Issue No.88Adherence to Mediterranean diet and physical activity practice in general population: an intersectional analysis of inequalities by sex and economic status普通人群中地中海饮食依从性与体力活动的实践：基于性别与经济状况的交叉性不平等分析DOI: 10.3389/fpubh.2025.1727223
Journal of migration and health IF: 02.900Volume 12, Issue No.89Perspectives of humanitarian actors on interprofessional care for persons living with diabetes: Lessons from Aleppo, Syria人道主义工作者对糖尿病患者跨专业护理的视角：来自叙利亚阿勒颇的经验DOI: 10.1016/j.jmh.2025.100355
Curēus IF: 01.300Volume 17, Issue 11No.90Roles of Psychiatry, Dietary, and Oncology Services in Occupational Medicine: A Comprehensive Review精神病学、营养学与肿瘤学服务在职业医学中的作用：一项综合综述DOI: 10.7759/cureus.98069
Curēus IF: 01.300Volume 17, Issue 11No.91Prevalence and Associated Factors of Glaucoma Among Adults in a Tertiary Care Center in Dubai, United Arab Emirates: A Retrospective Review阿拉伯联合酋长国迪拜一家三级医疗中心成人青光眼患病率及相关因素：一项回顾性研究DOI: 10.7759/cureus.98105
Curēus IF: 01.300Volume 17, Issue 11No.92Effective Limb Salvage Using a Distally Based Peroneus Brevis Flap for Distal Tibial Osteomyelitis使用远端蒂腓骨短肌瓣有效保肢治疗胫骨远端骨髓炎DOI: 10.7759/cureus.98065
ARYA Atherosclerosis IF: 00.600Volume 21, Issue 6No.93Six-month survival and predictors of mortality after ischemic stroke: A prospective cohort study in Iran伊朗缺血性卒中后六个月生存率及死亡预测因素：一项前瞻性队列研究DOI: 10.48305/arya.2025.45310.3060
South Asian journal of cancer IF: 00.600Volume 14, Issue 4No.94Practice Patterns and Incidence of F ebrile Neutr o penia in Patients R eceiving T riplet Drug Chemotherapeutic Regimens in G U T Cancers: Do We Need to Add WBC Growth Factors? (ForGeT GCSF Study)GU癌症患者接受三联药物化疗方案中的实践模式与发热性中性粒细胞减少症发生率：是否需要添加WBC生长因子？（ForGeT GCSF研究）DOI: 10.1055/s-0044-1789590
Frontiers in nutrition IF: 05.100Volume 12, Issue No.95Impact of α-linolenic acid supplementation on long-chain n-3 fatty acid profiles in Western, flexitarian, vegetarian, and vegan diets补充α-亚麻酸对西方、弹性素食、素食及纯素食饮食中长链n-3脂肪酸谱的影响DOI: 10.3389/fnut.2025.1727308
Korean J Community NutrVolume 29, Issue 1No.96[Association of ultra-processed food with diabetes and impaired fasting glucose in elderly populations (urban and rural): a cross-sectional study]韩国城乡老年人超加工食品摄入与糖尿病及空腹血糖受损的关联：一项横断面研究DOI: 10.5720/kjcn.2024.29.1.51
Nigerian Medical journalVolume 66, Issue 4No.97Glycemic control among People living with HIV and diabetes in Eastern Uganda: A cross-sectional study乌干达东部地区HIV合并糖尿病患者的血糖控制情况：一项横断面研究DOI: 10.71480/nmj.v66i4.984
Nigerian Medical journalVolume 66, Issue 4No.98Serum Galectin-3 as a Prognostic Biomarker in Acute Ischemic Stroke: A Comparative Cross-Sectional Study血清Galectin-3作为急性缺血性卒中预后生物标志物的比较横断面研究DOI: 10.71480/nmj.v66i4.875
NFS journal IF: 03.300Volume 41, Issue No.99Skeletal muscle disuse atrophy: protection by omega-3 polyunsaturated fatty acids骨骼肌废用性萎缩：omega-3多不饱和脂肪酸的保护作用DOI: 10.1016/j.nfs.2025.100253
J Integr Complement Med IF: 01.700Ahead of Print.No.100The Effects of Mandala Coloring Applied to Type 2 Diabetes Patients on Levels of Perceived Stress and Anxiety: A Randomized Controlled Study应用于2型糖尿病患者的曼陀罗绘画对感知压力和焦虑水平的影响：一项随机对照研究DOI: 10.1177/27683605251406492
Diabetic medicine IF: 03.400Ahead of Print.No.101Leaving better managed than when they arrived: A window of opportunity for people with diabetes admitted to hospital出院时病情管理优于入院：住院糖尿病患者的机遇之窗DOI: 10.1111/dme.70212
Diabetic medicine IF: 03.400Ahead of Print.No.102Healing through empowerment and active listening (HEALing): A mixed-methods evaluation of the feasibility and acceptability of a nurse-led self-care support intervention for people with diabetic foot ulcers通过赋能与积极倾听促进愈合：一项关于护士主导的糖尿病足溃疡患者自我护理支持干预措施的可行性、可接受性及效果混合方法研究评估DOI: 10.1111/dme.70187
Journal of cosmetic dermatology IF: 02.500Volume 25, Issue 1No.103Safety of Exogenous Recombinant Human Platelet-Derived Growth Factor-BB (rhPDGF-BB) for Medical and Cosmetic Applications: A Review外源性重组人血小板衍生生长因子-BB（rhPDGF-BB）在医学和美容应用中安全性的综述DOI: 10.1111/jocd.70636
Ann Otol Rhinol Laryngol IF: 01.200Ahead of Print.No.104Chronic Bacterial and Sicca Laryngitis: A Retrospective Cohort and Systematic Review慢性细菌性与干燥性喉炎：一项回顾性队列研究及系统综述DOI: 10.1177/00034894251405127
Gut and liver IF: 03.200Ahead of Print.No.105Increased Heart Failure Risk with Gastric Cancer Progression: A Nationwide Population-Based Cohort Study胃癌进展与心力衰竭风险增加相关：一项全国性人群队列研究DOI: 10.5009/gnl250209
Microorganisms IF: 04.200Volume 13, Issue 12No.106Fatal Congenital Toxoplasmosis with Progressive Liver Failure and Genomic Characterization of a Novel Isolate from the United States美国报告一例伴进行性肝衰竭的致死性先天性弓形虫病及其新型分离株的基因组特征分析DOI: 10.3390/microorganisms13122865
Microorganisms IF: 04.200Volume 13, Issue 12No.107Bacterial Adaptation to Stress Induced by Glyoxal/Methylglyoxal and Advanced Glycation End Products细菌对乙二醛/丙酮醛和晚期糖基化终末产物所致应激的适应DOI: 10.3390/microorganisms13122778
Microorganisms IF: 04.200Volume 13, Issue 12No.108Rhino-Orbital-Cerebral Mucormycosis Complicated by Vision Loss in a Patient with Uncontrolled Diabetes: A Case Report未控制糖尿病患者并发视力丧失的鼻-眶-脑毛霉菌病：一例报告DOI: 10.3390/microorganisms13122695
Molecules IF: 04.600Volume 30, Issue 24No.109Novel Trinorditerpene from Dysoxylum parasiticum (Osbeck) Kosterm: Leaf Extract with Cytotoxic, Antioxidant and α-Glucosidase Inhibitory Activities寄主臭椿叶片提取物中的新颖三降二萜：具有细胞毒性、抗氧化及α-葡萄糖苷酶抑制活性DOI: 10.3390/molecules30244747
Pharmaceuticals IF: 04.800Volume 18, Issue 12No.110Risk Factors for Intolerable Postoperative Pain After Vitreoretinal Surgery Under AoA-Guided General Anesthesia with Intravenous COX-3 Inhibitors: A Post Hoc AnalysisAoA引导的全身麻醉联合静脉COX-3抑制剂下玻璃体视网膜手术后难以忍受性疼痛的风险因素：一项事后分析DOI: 10.3390/ph18121826
Pharmaceuticals IF: 04.800Volume 18, Issue 12No.111Production of a Dulaglutide Analogue by Apoptosis-Resistant Chinese Hamster Ovary Cells in a 3-Week Fed-Batch Process抗凋亡中国仓鼠卵巢细胞在3周补料分批培养工艺中生产度拉糖肽类似物DOI: 10.3390/ph18121896
Avicenna journal of medicineVolume 15, Issue 4No.112Burden and Factors Associated with Depression and Anxiety Disorders in Pediatric Asthma: A Cross-Sectional Study儿童哮喘患者抑郁与焦虑障碍的负担及相关因素：一项横断面研究DOI: 10.1055/s-0045-1814096
Digital health IF: 03.300Volume 11, Issue No.113A deep learning-based early prediction framework for weight management using real-world lifelog data: GRU-ODE-Bayes model development and validation study基于深度学习的体重管理早期预测框架：利用真实世界生活日志数据的GRU-ODE-Bayes模型开发与验证研究DOI: 10.1177/20552076251406656
Health science reports IF: 02.100Volume 9, Issue 1No.114Awareness of Obesity and Diabetes in Libya: Insights From a Cross-Sectional Study利比亚肥胖与糖尿病意识：一项横断面研究的启示DOI: 10.1002/hsr2.71654
Health science reports IF: 02.100Volume 9, Issue 1No.115Association Between Adiposity and Low Total Serum Bilirubin Concentration: A Retrospective, Cross-Sectional Study脂肪含量与低总血清胆红素浓度之间的关联：一项回顾性横断面研究DOI: 10.1002/hsr2.71700
Journal of migration and health IF: 02.900Volume 12, Issue No.116A scoping review of overweight and obesity prevalence and determinants among immigrant adults in Nordic countries斯堪的纳维亚国家移民成人超重与肥胖患病率及决定因素的范围综述DOI: 10.1016/j.jmh.2025.100377
Przegl?d Gastroenterologiczny IF: 02.500Volume 20, Issue 4No.117Concordance of the rapid urease test and the histopathology report in detecting Helicobacter pylori infection in a bariatric population. A retrospective cohort study减重手术人群中快速尿素酶试验与组织病理学报告检测幽门螺旋杆菌感染的一致性：一项回顾性队列研究DOI: 10.5114/pg.2025.156847
Applications in plant sciences IF: 02.400Volume 13, Issue 6No.118PlantSAM: An object detection-driven segmentation pipeline for herbarium specimensPlantSAM：一种面向植物标本、由目标检测驱动的分割流水线DOI: 10.1002/aps3.70034
Frontiers in nutrition IF: 05.100Volume 12, Issue No.119Nutritional factors and survival in a cohort of patients with myelofibrosis骨髓纤维化患者队列中的营养因素与生存分析DOI: 10.3389/fnut.2025.1704844
Korean J Community NutrVolume 29, Issue 1No.120Nutrition education programs necessary for social welfare facilities for persons with disabilities: a cross-sectional study残疾人士社会福利机构营养教育项目的必要性：一项横断面研究DOI: 10.5720/kjcn.2024.29.1.1
Frontiers in immunology IF: 05.900Volume 16, Issue No.121IL-6 as an integrative biomarker of residual inflammation and visceral adiposity in psoriasis: a VAI threshold-dependent modelIL-6作为银屑病中残余炎症和内脏脂肪的整合性生物标志物：一个VAI阈值依赖模型DOI: 10.3389/fimmu.2025.1699343
Headache IF: 04.000Ahead of Print.No.122A unifying disease model of idiopathic intracranial hypertension: A narrative review特发性颅内高血压的统一疾病模型：一篇叙述性综述DOI: 10.1111/head.70030
Gut and liver IF: 03.200Ahead of Print.No.123Artificial Intelligence Applications in the Diagnosis, Treatment, and Prognosis of Hepatocellular Carcinoma人工智能在肝细胞癌诊断、治疗和预后中的应用DOI: 10.5009/gnl250268
Microorganisms IF: 04.200Volume 13, Issue 12No.124The Prevalence of Perineal Tears Among Women Having Spontaneous Vaginal Births with Intrapartum Fever产时发热妇女自然阴道分娩时会阴撕裂的发生率DOI: 10.3390/microorganisms13122815
Sensors IF: 03.500Volume 25, Issue 24No.125Trajectories of Adherence to Study-Prescribed Physical Activity Goals in a mHealth Weight Loss InterventionmHealth体重管理干预中参与者遵循体力活动目标的轨迹研究DOI: 10.3390/s25247595
Pharmaceuticals IF: 04.800Volume 18, Issue 12No.126The Impact of Maternal BMI on the Efficacy and Safety of Oral Misoprostol for Labor Induction母体BMI对口服米索前列醇引产的有效性和安全性的影响DOI: 10.3390/ph18121888
Pharmaceuticals IF: 04.800Volume 18, Issue 12No.127Coixol and Sinigrin from Coix lacryma-jobi L. and Raphanus sativus L. Promote Fat Browning in 3T3-L1 Adipocytes薏苡仁中的薏苡仁酯与萝卜籽中的黑芥子苷促进3T3-L1脂肪细胞脂肪棕色化DOI: 10.3390/ph18121843
Pharmaceuticals IF: 04.800Volume 18, Issue 12No.1286,7-Dihydroxy-4-methylcoumarin Suppresses Adipogenesis via AMPK and MAPK Signaling with In Silico Analysis of Adipogenic Proteins6,7-二羟基-4-甲基香豆素通过AMPK和MAPK信号通路抑制脂肪生成及基于脂肪生成蛋白的计算机模拟分析DOI: 10.3390/ph18121780
Nutrients IF: 05.000Volume 17, Issue 24No.129Use of Weight Loss Supplements According to the Purported Mechanisms of Action Among Polish Adults Living in an Obesogenic Environment: The Role of Sociodemographic and Health-Related Factors据宣称的作用机制分析波兰生活在致肥环境中成年人的减肥补充剂使用：社会人口与健康相关因素的作用DOI: 10.3390/nu17243963
Nutrients IF: 05.000Volume 17, Issue 24No.130Association Between Healthy Lifestyle and Cardiometabolic Risk in Higher Education Students in a Region of Peru: A Cross-Sectional Survey秘鲁某地区高等教育学生健康生活方式与心脏代谢风险的关联：一项横断面调查DOI: 10.3390/nu17243944
Nutrients IF: 05.000Volume 17, Issue 24No.131Learning from Peers: A Qualitative Study to Inform the Development of a Community Tailored Peer Support Intervention to Support Healthy Infant Growth向同伴学习：一项为制定社区定制化同伴支持干预以促进婴儿健康生长的定性研究DOI: 10.3390/nu17243941
Nutrients IF: 05.000Volume 17, Issue 24No.132Maternal Eating Styles and Restrictive Feeding Practices: Indirect Effects Through Perceived Child Appetite and Weight Concern母亲饮食风格与限制性喂养行为：通过感知儿童食欲和体重担忧的间接影响DOI: 10.3390/nu17243933
Nutrients IF: 05.000Volume 17, Issue 24No.133The Relationship of Sensory Profiles and Peripheral Biomarkers with Obesity and Eating Styles in Adolescence青少年肥胖与进食方式中感官特征及外周生物标志物的关系DOI: 10.3390/nu17243923
Nutrients IF: 05.000Volume 17, Issue 24No.134Eating Disorders in an Immigrant Population: Are Clinical Features and Treatment Outcomes Different from the Native-Born Spanish Population?移民人群的进食障碍：其临床特征与治疗结果是否与本土西班牙人群不同？DOI: 10.3390/nu17243914
Nutrients IF: 05.000Volume 17, Issue 24No.135Identifying Distinct Profiles of Nutrition Knowledge and Dietary Practices, and Their Determinants Among Adult Women: A Cross-Sectional Study识别成年女性营养知识与膳食实践的不同特征及其决定因素：一项横断面研究DOI: 10.3390/nu17243916
Nutrients IF: 05.000Volume 17, Issue 24No.136Dietary Patterns Influence Chronic Disease Risk and Health Outcomes in Older Adults: A Narrative Review膳食模式影响老年人慢性病风险与健康结局：一项叙述性综述DOI: 10.3390/nu17243910
Nutrients IF: 05.000Volume 17, Issue 24No.137Olfactory Capacity and Obesity in Chilean Adolescents智利青少年的嗅觉能力与肥胖DOI: 10.3390/nu17243903
Nutrients IF: 05.000Volume 17, Issue 24No.138The Impact of Physical Activity at School on the Nutritional Behavior of Overweight Children学校体力活动对超重儿童营养行为的影响DOI: 10.3390/nu17243905
Nutrients IF: 05.000Volume 17, Issue 24No.139Controversies and Perspectives of Time-Qualified Dietary Interventions时间限定饮食干预的争议与前景DOI: 10.3390/nu17243894
Nutrients IF: 05.000Volume 17, Issue 24No.140The Impact of Mindfulness Interventions upon Visual Attention and Attentional Bias Towards Food Cues: A Systematic Review正念干预对视觉注意及对食物线索注意偏向的影响：一项系统综述DOI: 10.3390/nu17243885
Nutrients IF: 05.000Volume 17, Issue 24No.141Early-Life Nutritional Determinants of Pediatric MASLD儿科代谢功能障碍相关脂肪性肝病的早期营养决定因素DOI: 10.3390/nu17243871
Nutrients IF: 05.000Volume 17, Issue 24No.142Clinical Implementation of Sustainable Functional Foods and Nutraceuticals in Metabolic Health: A Feasibility Study可持续功能性食品与营养素在代谢健康中的临床应用：一项可行性研究DOI: 10.3390/nu17243858
Nutrients IF: 05.000Volume 17, Issue 24No.143Lactiplantibacillus plantarum Strain 06CC2 Attenuates Fat Accumulation and Modulates the Gut Microbiota in a Mouse Model of Early-Stage Diet-Induced Obesity植物乳杆菌菌株06CC2减轻早期饮食诱导肥胖小鼠模型的脂肪积累并调节肠道菌群DOI: 10.3390/nu17243855
Nutrients IF: 05.000Volume 17, Issue 24No.144Role of Bioelectrical Impedance Analysis in Detecting Nutritional Disorders in Institutionalized Psychogeriatric Patients生物电阻抗分析在检测机构化老年精神科患者营养障碍中的作用DOI: 10.3390/nu17243839
Nutrients IF: 05.000Volume 17, Issue 24No.145Leader-Inspired Nutrition: A Framework for Promoting Healthy Nutrition Behaviors and a Nutritionally Fueled and Fit Military Force领导力驱动的营养：促进健康营养行为与构建营养驱动型军事强健力量的框架DOI: 10.3390/nu17243835
Nutrients IF: 05.000Volume 17, Issue 24No.146Determinants of the Availability of Special Diet Meals in Public Schools from Kraków (Poland): A Cross-Sectional Analysis波兰克拉科夫公立学校特殊膳食供应的决定因素：一项横断面分析DOI: 10.3390/nu17243834
Nutrients IF: 05.000Volume 17, Issue 24No.147The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive Review营养在类风湿关节炎发生、管理与预防中的作用：综合评述DOI: 10.3390/nu17243826
Nutrients IF: 05.000Volume 17, Issue 24No.148Exploring Obesity Subtypes: Cluster Analysis of Eating Behaviors, Food Addiction, and Psychopathology in Turkish Adults Seeking Obesity Treatment探索肥胖亚型：对寻求肥胖治疗的土耳其成年人的饮食行为、食物成瘾和精神病理学进行聚类分析DOI: 10.3390/nu17243823
Nutrients IF: 05.000Volume 17, Issue 24No.149Validity and Reliability of the Danish Version of the Adult Eating Behavior Questionnaire-Results from the South Danish Obesity Initiative成人进食行为问卷丹麦版的有效性和可靠性——来自南丹麦肥胖倡议的结果DOI: 10.3390/nu17243824
Nutrients IF: 05.000Volume 17, Issue 24No.150Health and Nutrition Interventions to Prevent Childhood Overweight and Obesity in Mexico and Latin America: A Systematic Review预防墨西哥及拉丁美洲儿童超重与肥胖的健康与营养干预措施：一项系统综述DOI: 10.3390/nu17243818
Nutrients IF: 05.000Volume 17, Issue 24No.151Assessment of Health Status, Emotional Well-Being, and the Prevalence of Overweight and Obesity in Children and Adolescents in the PICTURE Study (Wroclaw, Poland)PICTURE研究（波兰弗罗茨瓦夫）中儿童青少年健康状况、情感福祉及超重肥胖患病率评估DOI: 10.3390/nu17243817
Medicina IF: 02.400Volume 61, Issue 12No.152Six-Month Quality of Life and Health Outcomes After Bariatric Surgery: A Prospective Cohort Study from Latvia减重手术后六个月的生活质量与健康结局：一项来自拉脱维亚的前瞻性队列研究DOI: 10.3390/medicina61122238
Medicina IF: 02.400Volume 61, Issue 12No.153Long-Term Cancer Incidence Trends in Korea (2001-2020): An Age-Period-Cohort and Joinpoint Analysis with a Focus on Younger Cohorts韩国癌症发病率长期趋势（2001-2020）：基于年龄-时期-队列和连接点模型的分析，聚焦年轻队列DOI: 10.3390/medicina61122179
Cancer medicine IF: 03.100Volume 15, Issue 1No.154Positive Association Between Body Mass Index and the Likelihood of Reporting an Overall Cancer Diagnosis Among College Students in the United States美国大学生体重指数与自我报告癌症总体诊断可能性呈正相关DOI: 10.1002/cam4.71508
BMC public health IF: 03.600Volume 25, Issue 1No.155A preliminary study on the development of a chronic disease self-management curriculum for disability support workers: educational needs analysis针对残疾支持工作者的慢性病自我管理课程开发初步研究：教育需求分析DOI: 10.1186/s12889-025-25659-9
Journal of neuroscience research IF: 03.400Volume 104, Issue 1No.156Modulation of Magnetic Resonance Spectroscopy Levels of Glutamate and GABA by Ketamine in Treatment-Resistant Depression氯胺酮对难治性抑郁症患者磁共振波谱谷氨酸和γ-氨基丁酸水平的调节作用DOI: 10.1002/jnr.70102
Nutrients IF: 05.000Volume 17, Issue 24No.157Ophiopogon japonicus Root Extract Attenuates Obesity-Induced Muscle Atrophy Through Regulation of the PI3K-AKT-mTOR/FoxO3a Signaling Pathway and Lipid Metabolism in Mice and C2C12 Myotubes麦冬根提取物通过调节PI3K-AKT-mTOR/FoxO3a信号通路和脂质代谢减轻小鼠和C2C12肌管肥胖诱导的肌肉萎缩DOI: 10.3390/nu17243946
Nutrients IF: 05.000Volume 17, Issue 24No.158How the Intake of Pulses May Impact Metabolic Disorders and Dementia Risk: A Narrative Review脉冲摄入如何影响代谢紊乱和痴呆风险：一篇叙述性综述DOI: 10.3390/nu17243898
Nutrients IF: 05.000Volume 17, Issue 24No.159Nutrition and Physical Activity in an Interdisciplinary Approach to Migraine: A Narrative Review营养与体力活动在偏头痛跨学科治疗中的整合：一项叙述性综述DOI: 10.3390/nu17243869
Medicina IF: 02.400Volume 61, Issue 12No.160A Nationwide Analysis of Diabetes Mellitus and Intracranial Injuries: No Impact on Mortality but Prolonged Hospital Stays in Germany德国全国性分析：糖尿病与颅内损伤——对死亡率无影响但延长住院时间DOI: 10.3390/medicina61122187
Alzheimer's & dementia IF: 06.800Volume 12, Issue 1No.161Critical evaluation of real-world evidence of repurposable medicines in the Alzheimer's disease drug development pipeline using a target trial emulation基于目标试验仿真对阿尔茨海默病药物研发管线中可再利用药物的真实世界证据进行批判性评估DOI: 10.1002/trc2.70193
Tissue barriers IF: 04.000Ahead of Print.No.162Current therapeutic strategies in the management of diabetic foot ulcers当前糖尿病足溃疡的治疗策略DOI: 10.1080/21688370.2025.2611185
Molecules IF: 04.600Volume 30, Issue 24No.163From Elixirs to Geroscience: A Historical and Molecular Perspective on Anti-Aging Medicine从长生药到老年科学：抗衰老医学的历史与分子视角DOI: 10.3390/molecules30244728
Pharmaceuticals IF: 04.800Volume 18, Issue 12No.164Metformin Mitigates Diabetes-Driven Renal Senescence via Immunomodulation and the FABP4/FOXO1 Axis二甲双胍通过免疫调节及FABP4/FOXO1轴缓解糖尿病驱动的肾脏衰老DOI: 10.3390/ph18121834
Pharmaceuticals IF: 04.800Volume 18, Issue 12No.165BMP-7 Treatment Ameliorates PTEN-Akt Mediated Apoptosis and Adverse Cardiac Remodeling in Ponatinib-Induced CardiotoxicityBMP-7治疗通过调控PTEN-Akt通路改善普纳替尼诱导心脏毒性中的细胞凋亡和不良心脏重构DOI: 10.3390/ph18121776
Medicina IF: 02.400Volume 61, Issue 12No.166Heparin Resistance in Cardiac Surgery with Cardiopulmonary Bypass: Mechanisms, Clinical Implications, and Evidence-Based Management体外循环心脏手术中的肝素抵抗：机制、临床意义与循证管理DOI: 10.3390/medicina61122088
Medicina IF: 02.400Volume 61, Issue 12No.167National Utilization and Expenditure Trends of GLP-1 Receptor Agonists and Dual GLP-1/GIP Agonist in Croatia, 2017-2024克罗地亚GLP-1受体激动剂与GLP-1/GIP双重激动剂的国家使用与支出趋势（2017-2024年）DOI: 10.3390/medicina61122210
Diabetic medicine IF: 03.400Ahead of Print.No.168Wider determinants of health are crucial confounders in benchmarking treatment standards: Diabetic ketoacidosis as an example健康广泛决定因素是基准化治疗标准中关键的混杂因素：以糖尿病酮症酸中毒为例DOI: 10.1111/dme.70209
Exp Ther Med IF: 02.300Volume 31, Issue 2No.169Metabolic gene polymorphisms and type 2 diabetes mellitus risk: A systematic review and meta-analyses代谢基因多态性与2型糖尿病风险：一项系统评价与荟萃分析DOI: 10.3892/etm.2025.13049
Curēus IF: 01.300Volume 17, Issue 11No.170Neutrophil-to-Lymphocyte Ratio (NLR): A Predictor of Microvascular Complications in Type 2 Diabetes Mellitus中性粒细胞与淋巴细胞比值（NLR）：2型糖尿病微血管并发症的预测指标DOI: 10.7759/cureus.98079
Diabetic medicine IF: 03.400Ahead of Print.No.171User evaluation of the Hypo-METRICS app: A tool for real-time symptom reporting of hypoglycaemia用户对Hypo-METRICS app的评估：一种用于低血糖实时症状报告的工具DOI: 10.1111/dme.70185
Molecules IF: 04.600Volume 30, Issue 24No.172Synthetic Flozins in Cancer Prevention and Combination Strategies: Structural Insights and Therapeutic Potential合成格列净类药物在癌症预防和联合策略中的应用：结构见解与治疗潜力DOI: 10.3390/molecules30244681
Pharmaceuticals IF: 04.800Volume 18, Issue 12No.173Nerve Growth Factor in Diabetes Mellitus: Pathophysiological Mechanisms, Biomarkers and Therapeutic Opportunities糖尿病中的神经生长因子：病理生理机制、生物标志物与治疗机遇DOI: 10.3390/ph18121805
Pharmaceutics IF: 05.500Volume 17, Issue 12No.174Pharmacokinetic Landscape and Interaction Potential of SGLT2 Inhibitors: Bridging In Vitro Findings and Clinical ImplicationsSGLT2抑制剂的药代动力学图景与相互作用潜能：衔接体外发现与临床启示DOI: 10.3390/pharmaceutics17121604
Pharmaceutics IF: 05.500Volume 17, Issue 12No.175Oral Treatment of Obesity by GLP-1 and Its AnalogsGLP-1及其类似物的口服疗法治疗肥胖DOI: 10.3390/pharmaceutics17121596
BMC Med Inform Decis Mak IF: 03.800Ahead of Print.No.176Explainable extratreeclassifier model for early detection of type 2 diabetes: evidence from the PERSIAN Dena Cohort基于PERSIAN Dena Cohort证据的2型糖尿病早期检测可解释极端树分类器模型DOI: 10.1186/s12911-025-03333-9
Medicina IF: 02.400Volume 61, Issue 12No.177Adverse Pregnancy Outcomes in Women with Gestational Diabetes Using Different Diagnostic Criteria: A Study from the Northern Adriatic Region of Croatia使用不同诊断标准时妊娠期糖尿病女性的不良妊娠结局：一项来自克罗地亚北部亚得里亚海地区的研究DOI: 10.3390/medicina61122218
BMC pregnancy and childbirth IF: 02.700Ahead of Print.No.178Comparative analysis of inflammatory and metabolic biomarkers in PGDM and GDM pregnanciesPGDM 与 GDM 妊娠中炎症和代谢生物标志物的比较分析DOI: 10.1186/s12884-025-08597-7
Medicina IF: 02.400Volume 61, Issue 12No.179Cutaneous Melanoma in the Context of Aging衰老背景下的皮肤黑色素瘤DOI: 10.3390/medicina61122115
Medicina IF: 02.400Volume 61, Issue 12No.180Elevated Epicardial Adipose Tissue and Ischemic Stroke Risk: A Systematic Review and Meta-Analysis心外膜脂肪组织增多与缺血性卒中风险：一项系统评价与荟萃分析DOI: 10.3390/medicina61122128
Medicina IF: 02.400Volume 61, Issue 12No.181Improvement of Cardiometabolic Control with Dapagliflozin in Patients with Type 2 Diabetes in Primary Care: The AGORA-AP Study达格列净改善初级保健中2型糖尿病患者心脏代谢控制：AGORA-AP研究DOI: 10.3390/medicina61122087
Viruses IF: 03.500Volume 17, Issue 12No.182Cardiac Tissue Damage in a Female Animal Post-COVID Model: Relevance of Chemokine-Mediated Inflammation新冠病毒感染后女性动物模型中的心脏组织损伤：趋化因子介导炎症的相关性DOI: 10.3390/v17121629
Medicina IF: 02.400Volume 61, Issue 12No.183Pulmonary Function and Associated Prognostic Factors in Children After COVID-19: A Retrospective Cohort Study儿童COVID-19后肺功能及相关预后因素：一项回顾性队列研究DOI: 10.3390/medicina61122136
Pharmaceuticals IF: 04.800Volume 18, Issue 12No.184Association Between DPPs-4 Inhibitors and Bullous Pemphigoid: Reporting Odds Ratio Analysis Using EudraVigilance DatabaseDPP-4抑制剂与天疱疮的关联性：基于EudraVigilance数据库的报告比值比分析DOI: 10.3390/ph18121800
American journal of medicine openVolume 14, Issue No.185The Impact of Different Antidiabetic Drugs on Fracture Risk in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials With a Focus on SGLT2 Inhibitors不同降糖药物对2型糖尿病患者骨折风险的影响：聚焦于SGLT2抑制剂的随机对照试验系统综述与网络荟萃分析DOI: 10.1016/j.ajmo.2025.100115
Avicenna journal of medicineVolume 15, Issue 4No.186Understanding Type 2 Diabetes Mellitus and the Knowledge Gaps among Future Health Care Professionals: Insights from Saudi Arabia洞察沙特阿拉伯未来医疗从业者对2型糖尿病的认知与差距DOI: 10.1055/s-0045-1812884
PCN reports :Volume 4, Issue 4No.187Stereotypical diagnostic bias for alcohol-induced ketoacidosis could lead to death: Normal blood sugar levels in SGLT2 blocker-induced severe diabetic ketoacidosis对酒精性酮症酸中毒的刻板诊断偏见可能导致死亡：SGLT2抑制剂诱发重度正常血糖性糖尿病酮症酸中毒DOI: 10.1002/pcn5.70279
Curēus IF: 01.300Volume 17, Issue 11No.188Challenges and Strategies for Successful Insulin Pump Therapy in an Elderly Patient With Type 1 Diabetes and Comorbidities: A Case Report一例老年1型糖尿病合并多种并发症患者胰岛素泵治疗的成功挑战与策略：病例报告DOI: 10.7759/cureus.98093
Curēus IF: 01.300Volume 17, Issue 11No.189Polycystic Ovary Syndrome-Associated Acne: The Interplay of Hyperandrogenism, Insulin Resistance, and Therapeutic Strategies多囊卵巢综合征相关痤疮：高雄激素血症、胰岛素抵抗与治疗策略的相互作用DOI: 10.7759/cureus.98103
Curēus IF: 01.300Volume 17, Issue 11No.190Maternal Thyroid Hormone Evaluation in Women With Gestational Diabetes Mellitus in the Second Trimester孕中期妊娠期糖尿病女性的母体甲状腺激素评估DOI: 10.7759/cureus.98107
bioRxivVolume 2025, Issue No.191Small molecule inhibitor of PPARγ acetylation promotes insulin sensitization and browning of white adipose tissue with improved safetyPPARγ乙酰化小分子抑制剂促进胰岛素增敏与白色脂肪棕色化并提升安全性DOI: 10.64898/2025.12.15.694265
bioRxivVolume 2025, Issue No.192mRNA and Protein Expression of Fetal Insulin Receptor in Breast Cancer Cell Lines胎儿胰岛素受体在乳腺癌细胞系中的mRNA及蛋白表达DOI: 10.64898/2025.12.15.694420
J Clin Transl Hepatol IF: 04.200Volume 13, Issue 12No.193Nutrient-stimulated Hormone-based Therapies: A New Frontier in the Prevention and Management of MASH-associated Hepatocellular Carcinoma营养刺激激素疗法：预防和管理MASH相关肝细胞癌的新前沿DOI: 10.14218/JCTH.2025.00303
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.194Enhancing insulin secretion by pancreatic β-cell redifferentiation: a study of the anti-diabetic effects of berberine in vitro通过胰腺β细胞再分化增强胰岛素分泌：小檗碱体外抗糖尿病作用研究DOI: 10.3389/fendo.2025.1658671
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.195Real-world glycemic outcomes of a tubeless automated insulin delivery system: a single-center observational study in Italy无管路自动胰岛素输送系统的真实世界血糖结局：一项意大利单中心观察性研究DOI: 10.3389/fendo.2025.1717249
JCEM case reportsVolume 4, Issue 1No.196Exogenous Insulin Antibody Syndrome and Subsequent Severe Subcutaneous Insulin Resistance Complicating Type 1 Diabetes外源性胰岛素抗体综合征及后续严重皮下胰岛素抵抗并发1型糖尿病DOI: 10.1210/jcemcr/luaf300
Veterinary World IF: 02.000Volume 18, Issue 11No.197Optimization of insulin-like growth factor-1 supplementation enhances oocyte quality by modulating oxidative stress and apoptotic pathways during in vitro maturation of Kacang goat oocytes优化胰岛素样生长因子-1补充通过调节氧化应激和凋亡通路提升Kacang山羊卵母细胞体外成熟质量DOI: 10.14202/vetworld.2025.3545-3560
Frontiers in immunology IF: 05.900Volume 16, Issue No.198Macrophages: friend or foe in diabetes pathogenesis and therapy巨噬细胞：糖尿病发病机制与治疗中的朋友还是敌人？DOI: 10.3389/fimmu.2025.1625391
Frontiers in immunology IF: 05.900Volume 16, Issue No.199A diet-induced obese and diabetic host phenotype reduces mosquito ZIKV infections and remodels gut metabolism饮食诱导的肥胖与糖尿病宿主表型可降低蚊子寨卡病毒感染并重塑其肠道代谢DOI: 10.3389/fimmu.2025.1704301
Future microbiology IF: 02.400Ahead of Print.No.200Superficial fungal infections in patients with diabetes. Is hyperglycemia the only associated factor?糖尿病患者浅部真菌感染：高血糖是唯一的关联因素吗？DOI: 10.1080/17460913.2025.2607353
J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.201Approach to the Patient - Mitochondrial Diabetes: Contemporary Cases and Precision Medicine Approach病例精析：线粒体糖尿病——当代病例与精准医学方法DOI: 10.1210/clinem/dgaf698
Veterinary sciences IF: 02.300Volume 12, Issue 12No.202Evaluation of Pancreatic Endocrine Reprogramming in Diabetic Cats糖尿病猫胰腺内分泌重编程的评估DOI: 10.3390/vetsci12121167
Microorganisms IF: 04.200Volume 13, Issue 12No.203Glucose-Lowering Effects and Safety of Bifidobacterium longum CKD1 in Diabetic Dogs and Cats长双歧杆菌CKD1在糖尿病犬和猫中的降血糖效应及安全性DOI: 10.3390/microorganisms13122881
Pharmaceuticals IF: 04.800Volume 18, Issue 12No.204Role of the Insulin Receptor in Mediating Cytosolic Delivery of Proteins by a Modified Cell-Penetrating Peptide胰岛素受体在介导修饰型细胞穿透肽递送蛋白质至胞质中的作用DOI: 10.3390/ph18121885
Pharmaceuticals IF: 04.800Volume 18, Issue 12No.205An Ongoing Search for Multitarget Ligands as Potential Agents for Diabetes Mellitus and Its Long-Term Complications: New Insights into (5-Arylidene-4-oxothiazolidin-3-yl)alkanoic Acid Derivatives对糖尿病及其长期并发症潜在多靶点药物的持续探索：关于（5-芳亚甲基-4-氧代噻唑烷-3-基）链烷酸衍生物的新见解DOI: 10.3390/ph18121863
Pharmaceuticals IF: 04.800Volume 18, Issue 12No.206Challenge of Corneal Ulcer Healing: A Novel Conceptual Framework, the "Triad" of Corneal Ulcer Healing/Corneal Neovascularization/Intraocular Pressure, and Avascular Tendon Healing, for Evaluation of Corneal Ulcer Therapy, Therapy of Neovascularization, Glaucoma Therapy, and Pentadecapeptide BPC 157 Efficacy角膜溃疡愈合的挑战：一种新的概念框架——“三联征”（角膜溃疡愈合↔角膜新生血管↔眼内压）以及无血管肌腱愈合——用于评价角膜溃疡治疗、新生血管治疗、青光眼治疗和十五肽BPC 157的有效性DOI: 10.3390/ph18121822
Pharmaceuticals IF: 04.800Volume 18, Issue 12No.207Curcumin and Tetrahydrocurcumin as Multi-Organ Modulators of the Adipose Tissue-Gut-Liver Axis: Mechanistic Insights, Therapeutic Potential, and Translational Challenges姜黄素与四氢姜黄素作为脂肪组织-肠道-肝脏轴的多器官调节剂：机制见解、治疗潜力与转化挑战DOI: 10.3390/ph18121791
Pharmaceutics IF: 05.500Volume 17, Issue 12No.208Systematic Development and Characterization of Enzyme-Free, Borax-Crosslinked Microneedles for Glucose-Responsive Insulin Delivery and In Vivo Glycemic Mitigation用于葡萄糖响应性胰岛素递送与体内血糖调节的无酶、硼砂交联微针的系统性开发与表征DOI: 10.3390/pharmaceutics17121578
Pharmaceutics IF: 05.500Volume 17, Issue 12No.209Inulin Reverses Intestinal Mrp2 Downregulation in a Diet-Induced Obesity Mouse Model: Role of Intestinal Microbiota as a Pivotal Modulator菊粉逆转饮食诱导肥胖小鼠模型中肠道Mrp2下调：肠道微生物群作为关键调节因子的作用DOI: 10.3390/pharmaceutics17121575
Pharmaceutics IF: 05.500Volume 17, Issue 12No.210Nanoparticle-Based Oral Insulin Delivery: Challenges, Advances, and Future Directions基于纳米颗粒的口服胰岛素递送：挑战、进展与未来方向DOI: 10.3390/pharmaceutics17121563
Pharmaceutics IF: 05.500Volume 17, Issue 12No.211In Silico Hypothesis Testing in Drug Discovery: Using Quantitative Systems Pharmacology Modeling to Evaluate the Therapeutic Value of Proinsulin Conversion to Insulin Therapy for Type 2 Diabetes Mellitus药物发现中的计算机模拟假设检验：使用定量系统药理学模型评估胰岛素原转化为胰岛素疗法对2型糖尿病的治疗价值DOI: 10.3390/pharmaceutics17121522
Nutrients IF: 05.000Volume 17, Issue 24No.212Mice Condition Cephalic Insulin Responses to the Flavor of Different Laboratory Chows小鼠对不同实验室饲料风味建立头期胰岛素反应DOI: 10.3390/nu17243880
Nutrients IF: 05.000Volume 17, Issue 24No.213Metabolic and Neuroenergetic Effects of Intranasal Vitamin C Application in the Human Brain鼻内应用维生素C对人脑代谢与神经能量学的影响DOI: 10.3390/nu17243875
Nutrients IF: 05.000Volume 17, Issue 24No.214Prediction of Postprandial Blood Glucose Variability Using Machine Learning in Frequent Insulin Injection Therapy with a Simplified Carbohydrate Counting Model使用机器学习和简化碳水化合物计数模型预测频繁胰岛素注射治疗中的餐后血糖变异性DOI: 10.3390/nu17243832
Nutrients IF: 05.000Volume 17, Issue 24No.215Gut Microbiota and Metabolic Modulation by Slow-Release Protein Substitutes in Phenylketonuria: Findings from the PREMP Study缓释蛋白质替代品对苯丙酮尿症患者肠道微生物群及代谢的调节作用：PREMP研究结果DOI: 10.3390/nu17243829
Micromachines IF: 03.000Volume 16, Issue 12No.216Pump-Free Insulin Delivery via an SLA-Printed Hollow Microneedle Patch with an Integrated Self-Sealing Reservoir基于SLA打印中空微针贴片结合自密封储库的无泵胰岛素递送系统DOI: 10.3390/mi16121322
Medicina IF: 02.400Volume 61, Issue 12No.217The Prevalence of H. pylori Among Jordanian Type 2 Diabetic Patients and Its Association with ABO Blood Group幽门螺杆菌在约旦2型糖尿病患者中的流行情况及其与ABO血型的关联DOI: 10.3390/medicina61122167
Medicina IF: 02.400Volume 61, Issue 12No.218Can Insulin Drops Accelerate Corneal Healing After Corneal Cross-Linking? A Preliminary Case Series胰岛素滴眼液能加速角膜交联术后的角膜愈合吗？一项初步病例系列研究DOI: 10.3390/medicina61122101
Nutrients IF: 05.000Volume 17, Issue 24No.219Nutrient-Induced Remodeling of the Adipose-Cardiac Axis: Metabolic Flexibility, Adipokine Signaling, and Therapeutic Implications for Cardiometabolic Disease营养素诱导的脂肪-心脏轴重塑：代谢灵活性、脂肪因子信号与心脏代谢疾病的治疗启示DOI: 10.3390/nu17243945
Nutrients IF: 05.000Volume 17, Issue 24No.220C. cochlearium 2316 Ameliorates High-Fat Diet-Induced Obesity and Metabolic Syndrome Risk Factors via Enhanced Energy Expenditure and Glucose HomeostasisC. cochlearium 2316通过增强能量消耗和血糖稳态改善高脂饮食诱导的肥胖与代谢综合征风险因素DOI: 10.3390/nu17243848
Medicina IF: 02.400Volume 61, Issue 12No.221A Comparison of Periodontal Health in Elderly Individuals with and Without Metabolic Syndrome: A Retrospective Study代谢综合征与老年牙周健康状况比较：一项回顾性研究DOI: 10.3390/medicina61122200
Medicina IF: 02.400Volume 61, Issue 12No.222Nutrition Counseling Frequency and Telehealth Integration on Cardiometabolic Outcomes in Metabolic Syndrome: A Randomized Controlled Trial in Turkey营养咨询频率与远程医疗整合对代谢综合征心脏代谢结果的影响：一项土耳其随机对照试验DOI: 10.3390/medicina61122124
Medicina IF: 02.400Volume 61, Issue 12No.223Prevalence of Cardiovascular-Kidney-Metabolic (CKM) Syndrome in Lithuanian Adults: Insights from a Nationwide Real-World Study Using Electronic Health Records立陶宛成年人心血管-肾脏-代谢综合征患病率：基于全国电子健康记录的真实世界研究见解DOI: 10.3390/medicina61122106
Investig Clin Urol IF: 02.100Volume 67, Issue 1No.224Metabolic syndrome and its components as independent risk factors for nocturia: A national cross-sectional analysis代谢综合征及其组分作为夜尿症的独立危险因素：一项全国性横断面分析DOI: 10.4111/icu.20250261
Case Rep Oncol Med IF: 00.600Volume 2025, Issue No.225Hypertriglyceridemia-Induced Acute Pancreatitis Associated with Ruxolitinib for Hemophagocytic Lymphohistiocytosis: A Case Report鲁索替尼治疗噬血细胞性淋巴组织细胞增生症相关的高甘油三酯血症诱发急性胰腺炎：一例病例报告DOI: 10.1155/crom/7271334
Veterinary World IF: 02.000Volume 18, Issue 11No.226Integrative metabolomics and hormonal profiling reveal biomarkers of milk yield efficiency in Sapera dairy goats under tropical conditions整合代谢组学与激素谱分析揭示热带条件下Sapera奶山羊产奶效率的生物标志物DOI: 10.14202/vetworld.2025.3594-3606
Molecules IF: 04.600Volume 30, Issue 24No.227Design and Biological Evaluation of Monoterpene-Conjugated (S)-2-Ethoxy-3-(4-(4-hydroxyphenethoxy)phenyl)propanoic Acids as New Dual PPARα/γ Agonists单萜共轭的(S)-2-乙氧基-3-(4-(4-羟基苯乙氧基)苯基)丙酸作为新型双重PPARα/γ激动剂的设计与生物活性评估DOI: 10.3390/molecules30244775
Molecules IF: 04.600Volume 30, Issue 24No.228Protective Metabolic Effects of Chickpea Sprout Against Obesity-Induced Insulin Resistance and Hypoestrogenism in Rats鹰嘴豆芽对肥胖诱导的胰岛素抵抗及低雌激素血症大鼠模型的保护性代谢效应DOI: 10.3390/molecules30244673
Nutrients IF: 05.000Volume 17, Issue 24No.229Refining MASLD Phenotypes: Clinical, Metabolic, and Elastographic Differences Between Adipose Tissue Dysfunction and Obesity-Driven Disease细化MASLD表型：脂肪组织功能障碍与肥胖驱动疾病之间的临床、代谢与弹性成像差异DOI: 10.3390/nu17243940
Nutrients IF: 05.000Volume 17, Issue 24No.230Opuntia dillenii as a Nutraceutical and Dietary Resource for Disease Prevention and Management: A Systematic ReviewOpuntia dillenii作为营养保健品与膳食资源在疾病预防和管理中的作用：一项系统综述DOI: 10.3390/nu17243915
Nutrients IF: 05.000Volume 17, Issue 24No.231Redox Response in Postoperative Metabolic and Bariatric Surgery: New Insights into Cardiovascular Risk Markers代谢和减重术后的氧化还原反应：心血管风险标志物的新见解DOI: 10.3390/nu17243821
Medicina IF: 02.400Volume 61, Issue 12No.232Impact of Obstructive Sleep Apnea-Hypopnea Syndrome Severity on Heart Rate Variability and QTc Interval in Hypertensive Patients阻塞性睡眠呼吸暂停低通气综合征严重程度对高血压患者心率变异性及QTc间期的影响DOI: 10.3390/medicina61122221
Medicina IF: 02.400Volume 61, Issue 12No.233Cardiometabolic Risk Factors Among Adults in a Rural Amazonian Peruvian Population秘鲁农村亚马逊地区成年人心血管代谢风险因素DOI: 10.3390/medicina61122206
Pharmaceuticals IF: 04.800Volume 18, Issue 12No.234Rosuvastatin Versus Atorvastatin for Cardiovascular Disease Risk in Patients with Type 2 Diabetes: A Korean Cohort Study瑞舒伐他汀与阿托伐他汀对2型糖尿病患者心血管疾病风险的比较：一项韩国队列研究DOI: 10.3390/ph18121860
Nigerian Medical journalVolume 66, Issue 4No.235Assessment of Peripheral Arterial Disease among Type 2 Diabetes Patients in Calabar, Nigeria尼日利亚卡拉巴尔2型糖尿病患者外周动脉疾病评估DOI: 10.71480/nmj.v66i4.560
Medicina IF: 02.400Volume 61, Issue 12No.236Serum Trimethylamine N-Oxide Levels Are Associated with Peripheral Artery Disease in Patients with Type 2 Diabetes Mellitus血清三甲胺N-氧化物水平与2型糖尿病患者的周围动脉疾病相关DOI: 10.3390/medicina61122243
JEADV IF: 08.000Ahead of Print.No.237French guidelines on systemic treatments for moderate-to-severe psoriasis in adults: Update 2025法国成人中重度银屑病系统治疗指南：2025年更新DOI: 10.1111/jdv.70263
Front Mol Biosci IF: 04.000Volume 12, Issue No.238Retraction: Circular ribonucleic acid circFTO promotes angiogenesis and impairs blood-retinal barrier via targeting the miR-128-3p/Thioredoxin interacting protein axis in diabetic retinopathy撤稿：环状RNA circFTO通过靶向miR-128-3p/硫氧还蛋白相互作用蛋白轴促进血管生成并损害血-视网膜屏障：糖尿病视网膜病变研究DOI: 10.3389/fmolb.2025.1727243
Pharmaceutics IF: 05.500Volume 17, Issue 12No.239Enhanced Ocular Delivery of Epalrestat Using Nanostructured Lipid Carrier Laden Soft Contact Lens利用载有纳米结构脂质载体的软性接触镜增强依帕司他的眼部递送DOI: 10.3390/pharmaceutics17121515
Medicina IF: 02.400Volume 61, Issue 12No.240Proliferative Diabetic Retinopathy in Young-Onset Type 1 Diabetes in Croatia: Risk Factors and a Predictive Economic Model for National Screening克罗地亚年轻起病1型糖尿病患者中增生性糖尿病视网膜病变的风险因素及全国筛查预测经济模型DOI: 10.3390/medicina61122168
BMC infectious diseases IF: 03.000Volume 25, Issue 1No.241Remdesivir safety and clinical outcomes in pediatric COVID-19: a retrospective study瑞德西韦在儿科COVID-19患者中的安全性与临床结局：一项回顾性研究DOI: 10.1186/s12879-025-12155-z
179
Diabetes Mellitus(DM)
糖尿病
120
Obesity
肥胖症
71
Insulin
胰岛素
31
Type 2 diabetes mellitus(T2DM)
2型糖尿病
18
Metabolic Syndrome
代谢综合征
11
Hypoglycemic Agents
降糖药
10
Diabetic Retinopathy
糖尿病视网膜病
9
Metformin
二甲双胍
8
Diabetic Foot
糖尿病足
7
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
6
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
5
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
4
Type 1 diabetes mellitus(T1DM)
1型糖尿病
2
Liraglutide
利拉鲁肽
2
Semaglutide
司美格鲁肽
2
Diabetic Neuropathies
糖尿病性神经病变
2
gamma-Aminobutyric Acid(GABA)
γ-氨基丁酸
2
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
2
Dapagliflozin
达格列净
2
Diabetes Complications
糖尿病并发症
2
Diabetic acidosis
糖尿病性酸中毒
1
Dulaglutide
度拉糖肽
1
Gastrointestinal lipase inhibitor
胃肠道脂肪酶抑制剂
1
Orlistat
奥利司他
1
Diabetes mellitus in pregnancy
妊娠期糖尿病
1
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
1
Vildagliptin
维格列汀
1
Gabapentin
加巴喷丁
编辑：天纳乾坤
审校：天纳乾坤
临床结果
2026-01-01
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12月15日，美国旧金山和中国苏州——信达生物制药集团（香港联交所股票代码：01801），一家致力于研发、生产和销售肿瘤、自身免疫、代谢及心血管、眼科等重大疾病领域创新药物的生物制药公司，宣布：信尔美®（胰高血糖素[GCG] /胰高血糖素样肽-1[GLP-1] 双受体激动剂，玛仕度肽注射液）获中国澳门特别行政区药品监管部门批准上市，用于成人肥胖或超重患者的长期体重控制。截至目前，信达生物多款创新产品已在印度尼西亚、中国香港、中国澳门、中国台湾等多个国家或地区获批上市。
信尔美®（玛仕度肽注射液）是全球首个用于体重管理的GCG/GLP-1双受体激动剂。其独特的双激动作用机制，在激动GLP-1受体抑制食欲减少热量摄入的基础上，同时激活GCG受体，促进脂肪燃烧，降低内脏脂肪含量，进一步增强玛仕度肽减重效果。临床研究表明，使用玛仕度肽可实现强效减重，降低肝脏脂肪含量超 80%2，腰围减少达11cm2，颈围减少达3cm3，兼顾改善血糖、血压、血脂、血尿酸和转氨酶水平等心血管及代谢指标2，带来全面获益，获评2025年全球十大最受期待药物之一（FIERCE Pharma 2025），其研究成果发表于《新英格兰医学杂志》，并特配专家评述1。
今年10月，玛仕度肽在Ⅲ期临床试验DREAMS-3（试验登记号：NCT06184568）中达成主要终点，研究结果显示，在中国2型糖尿病（T2D）合并肥胖患者中，玛仕度肽在血糖控制与体重管理的综合疗效显著优于司美格鲁肽，并在空腹血糖、腰围、收缩压、甘油三酯等多项心血管代谢风险因素上展现出更优改善效果。
值得一提的是，此次获批的玛仕度肽注射液在设计上充分兼顾患者使用的便利性与安全性。一次性注射笔杜绝交叉污染风险；产品采用隐针设计，其特有的X切面针头经对比研究证实，可减轻注射疼痛感、提升皮肤穿刺顺畅度，助力患者获得更舒适的注射体验4。这些设计细节不仅提升了用药便捷性，更有助于提高患者的长期治疗依从性，为临床应用增添了实用优势。
作为中国领先的生物制药企业，信达生物已建立包含30余个新药品种的产品管线，覆盖肿瘤、自身免疫、代谢、眼科等重大疾病领域。此次玛仕度肽在中国澳门获批，不仅为中国澳门肥胖症患者带来突破性的体重管理方案，也为提升中国澳门公共卫生水平和推动医疗创新发展注入新动力。信达生物将继续秉持“开发出老百姓用得起的高质量生物药”的使命，推动更多创新药物走向更广阔的市场，惠及全球患者。
关于玛仕度肽（IBI362）
玛仕度肽（IBI362）是信达生物与礼来制药共同推进的一款胰高血糖素（GCG）/胰高血糖素样肽-1（GLP-1）双受体激动剂。作为一种哺乳动物胃泌酸调节素（OXM）类似物，玛仕度肽除了通过激动GLP-1R促进胰岛素分泌、降低血糖和减轻体重外，还可通过激动GCGR增加能量消耗增强减重疗效，同时改善肝脏脂肪代谢。玛仕度肽已在多项临床研究中展现出优秀的减重和降糖疗效，以及降低腰围、血脂、血压、血尿酸、肝酶及肝脏脂肪含量，以及改善胰岛素敏感性，带来多重代谢获益。
玛仕度肽当前共开展或完成了七项III期临床研究，包括：
在中国超重或肥胖参与者中开展的III期临床研究（GLORY-1）；
在中国中重度肥胖参与者中开展的III期临床研究（GLORY-2）；
在初治的中国2型糖尿病患者中开展的III期临床研究（DREAMS-1）；
在口服药物治疗血糖控制不佳的中国2型糖尿病参与者中开展的对比玛仕度肽和度拉糖肽的III期临床研究（DREAMS-2）；
在中国2型糖尿病合并肥胖的参与者中开展的对比玛仕度肽和司美格鲁肽的III期临床研究（DREAMS-3）;
在中国超重或肥胖合并代谢相关脂肪性肝病（MAFLD）参与者中开展的III期临床研究（GLORY-3）;
在中国阻塞性睡眠呼吸暂停（OSA）合并肥胖参与者中开展的III期临床研究（GLORY-OSA）。
其中，前五项III期临床研究均已达成终点，后两项III期临床研究还在进行中。
此外，玛仕度肽还有多项新临床研究进行中，其中包括：治疗青少年肥胖，代谢相关脂肪性肝炎（MASH），射血分数保留心力衰竭（HFpEF），及更高剂量头对头替尔泊肽治疗中重度肥胖等临床研究。
玛仕度肽凭借出色的研究数据多次获得学术及行业内的认可。玛仕度肽此前在中国超重/肥胖受试者中进行的II期临床研究被国际顶尖期刊Nature Communications评选为临床转化医学领域最重要的50个研究之一并被列为主编精选研究。同时，玛仕度肽被知名医药领域网站FIERCE Pharma评入2025全球十大最受期待创新药榜单。除此之外，玛仕度肽的临床研究结果多次亮相《新英格兰医学杂志》（The New England Journal of Medicine）, Nature Communications , Diabetes Care , eClinicalMedicine等国际知名期刊和美国糖尿病协会（ADA）科学会议、欧洲糖尿病研究学会（EASD）年会等学术大会，是中国内分泌代谢领域首个临床研究成果发布在《新英格兰医学杂志》的创新药物，体现了其重要的临床意义。
*玛仕度肽已获NMPA批准两项适应症，第一项为在控制饮食和增加体力活动基础上对成人患者的长期体重控制，初始体重指数（BMI）为：
BMI≥28 kg/m2（肥胖），或
BMI≥24 kg/m2（超重），并伴有至少一种体重相关的合并症（例如高血糖、高血压、血脂异常、脂肪肝、阻塞性睡眠呼吸暂停综合征等）。
第二项适应症为用于成人2型糖尿病患者的血糖控制：
单药治疗
单纯饮食控制和运动干预后血糖仍控制不佳的成人2型糖尿病患者；
联合治疗
在饮食控制和运动基础上，接受二甲双胍和/或磺脲类药物、接受二甲双胍和/或钠-葡萄糖共转运蛋白2抑制剂（SGLT2i）类药物治疗血糖仍控制不佳的成人2型糖尿病患者。
关于信达生物
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“始于信，达于行”，开发出老百姓用得起的高质量生物药，是信达生物的使命和目标。信达生物成立于2011年，致力于研发、生产和销售肿瘤、自身免疫、代谢、眼科等重大疾病领域的创新药物，让我们的工作惠及更多的生命。公司已有17个产品获得批准上市，它们分别是信迪利单抗注射液（达伯舒®），贝伐珠单抗注射液（达攸同®），阿达木单抗注射液（苏立信®），利妥昔单抗注射液（达伯华®），佩米替尼片（达伯坦®），奥雷巴替尼片（耐立克®）， 雷莫西尤单抗注射液（希冉择®），塞普替尼胶囊（睿妥®），伊基奥仑赛注射液（福可苏®），托莱西单抗注射液（信必乐®），氟泽雷塞片（达伯特®），匹妥布替尼片(捷帕力®)，己二酸他雷替尼胶囊（达伯乐®），利厄替尼片（奥壹新®）和替妥尤单抗N01注射液（信必敏®），玛仕度肽注射液（信尔美®）和匹康奇拜单抗注射液（信美悦®）。目前，同时还有1个品种在NMPA审评中，4个新药分子进入III期或关键性临床研究，另外还有15个新药品种已进入临床研究。
公司已与礼来、罗氏、赛诺菲、Incyte和MD Anderson 癌症中心等国际合作方达成30多项战略合作。信达生物在不断自研创新药物、谋求自身发展的同时，秉承经济建设以人民为中心的发展思想。多年来，始终心怀科学善念，坚守“以患者为中心”，心系患者并关注患者家庭，积极履行社会责任。公司陆续发起、参与了多项药品公益援助项目，让越来越多的患者能够得益于生命科学的进步，买得到、用得起高质量的生物药。截至目前，信达生物患者援助项目已惠及20余万普通患者，药物捐赠总价值36亿元人民币。信达生物希望和大家一起努力，提高中国生物制药产业的发展水平，以满足百姓用药可及性和人民对生命健康美好愿望的追求。
详情请访问公司网站：www.innoventbio.com或公司领英账号：Innovent Biologics。
声明：
1.信达不推荐任何未获批的药品/适应症使用。
2.雷莫西尤单抗注射液（希冉择®），塞普替尼胶囊（睿妥®）和匹妥布替尼片（捷帕力®）由礼来公司研发。
参考文献：
1. Ji L, et al. N Engl J Med. 2025 May 25. doi: 10.1056/NEJMoa2411528
2. Data from Phase 2 study of mazdutide 9mg, data on file.
3. Data from the Phase 2 study of Mazdutide 9 mg, data on file.
4. Amer Jaber, et al. BMC Neurology. October 10, 2008. doi: 10.1186/1471-2377-8-38
5. Ultra-fine needle patent number: CN1169320A
声明：本文仅供医疗卫生专业人士了解最新医药资讯参考使用，不代表本平台观点。该等信息不能以任何方式取代专业的医疗指导，也不应被视为诊疗建议，如果该信息被用于资讯以外的目的，本站及作者不承担相关责任。
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上市批准临床结果临床3期临床2期
2025-12-31
·竹林医迅
NEWS：
当2025年12月《自然》（Nature）主刊以“背靠背”形式，同期刊登信达生物玛仕度肽注射液（信尔美®）的两项Ⅲ期临床研究时，全球代谢领域学术界为之震动——这是《自然》创刊以来首次为代谢领域的两项Ⅲ期研究开辟“绿色通道”，更让这款中国原创双靶药物，成为全球首个同时斩获《自然》与《新英格兰医学杂志》两大顶刊认可的GLP-1类药物。从5月减重研究登顶《新英格兰医学杂志》，到12月降糖研究“霸屏”《自然》，短短半年内，玛仕度肽用实打实的临床数据，宣告中国生物制药在代谢疾病领域实现从“跟跑”到“领跑”的质变。
此次登陆《自然》的DREAMS-1与DREAMS-2研究，并非简单的疗效验证，而是精准切入中国2型糖尿病患者的治疗痛点：针对“初治患者”与“口服药失效患者”两大核心人群，量身设计临床试验方案，最终用本土化数据交出了令人信服的答案。正因为研究设计的针对性、数据的严谨性，文章得以通过《自然》“加速预览”机制火速上线，让全球医生与研究者第一时间看到代谢治疗的“中国方案”。
双靶协同“开挂”
不止降糖减重，更护全身代谢
玛仕度肽的核心竞争力，在于其全球首创的“GCG/GLP-1双受体激动剂”设计——跳出传统单靶点药物的局限，通过同时激活两大代谢关键受体，实现“控糖+减重+护代谢”的三重获益，尤其贴合中国人“代谢综合征”高发的体质特征。
01
血糖控制：精准打击
针对初治患者（DREAMS-1研究）：单药治疗24周，玛仕度肽6mg组糖化血红蛋白（HbA1c）下降2.15%，81.8%的患者实现HbA1c<7%的核心达标目标，而安慰剂组仅11.7%达标，差距高达7倍；
针对口服药失效患者（DREAMS-2研究）：联合治疗28周，玛仕度肽6mg组HbA1c降低1.66%，达标率70.4%，显著优于单靶点药物度拉糖肽（61.6%），为“难治性血糖”提供新解法。
02
体重管理：直击内脏脂肪
DREAMS-1研究：24周内平均减重7.34%，超六成患者（64%）体重下降≥5%，告别“降糖必增重”的临床困境；
DREAMS-2研究：28周平均减重8.53%，近七成半患者（73.1%）体重降幅≥5%，而度拉糖肽组仅2.77%的减重效果、26.6%的达标率。
03
代谢保护：多指标全面优化
临床数据显示，玛仕度肽还能同步改善空腹血糖、收缩压/舒张压、甘油三酯、肝酶等关键指标，尤其能通过激活GCG受体增加能量消耗，减少肝脏脂肪堆积，从根源降低脂肪肝、心血管疾病等代谢相关并发症的发生风险。
“头对头”司美格鲁肽
48%患者实现“双达标”
国产药改写市场格局
如果说顶刊认证是“学术背书”，那么与全球“明星药物”司美格鲁肽的“头对头”研究，则是玛仕度肽临床实力的“终极考验”。2025年10月公布的DREAMS-3研究结果，给出了颠覆性答案——这是全球首个在糖尿病领域开展的GCG/GLP-1双靶药物与司美格鲁肽的直接对比研究。
32周治疗后，数据呈现优势：
玛仕度肽组48%的患者同时达成“HbA1c<7%（血糖达标）+体重下降≥10%（深度减重）”的高标准，是司美格鲁肽组（21%）的2.3倍；
核心疗效指标上，玛仕度肽HbA1c降幅（2.03%）、体重降幅（10.29%）均全面超越司美格鲁肽（1.84%、6.00%）。
这一结果意味着，在糖尿病与肥胖合并治疗的核心市场，国产创新药未来将重塑全球代谢疾病治疗的市场格局。
玛仕度肽的无限可能
目前，玛仕度肽已在中国正式获批两大核心适应症——成人2型糖尿病血糖控制、成人肥胖/超重的长期体重管理。更值得期待的是，这款“中国造”新药正在向更多代谢相关疾病拓展，有望成为覆盖全生命周期、多代谢疾病的“平台型药物”：
在中国超重或肥胖合并代谢相关脂肪性肝病（MAFLD）参与者中开展的Ⅲ期临床研究（GLORY-3）；
在中国阻塞性睡眠呼吸暂停（OSA）合并肥胖参与者中开展的Ⅲ期临床研究（GLORY-OSA）；
小结
从学术巅峰到临床落地，从击败国际巨头到拓展多适应症，玛仕度肽的每一步突破，都在改写中国创新药的历史，对于中国1.4亿糖尿病患者、数亿超重/肥胖人群而言，这款“中国造”双靶新药的出现，不仅意味着更有效的治疗选择，更标志着中国代谢疾病治疗正式进入“自主创新、全球领跑”的新时代——未来，来自中国的医药创新，将为全球患者带来更多希望。
参考文献：
1.Zhu, D., Zhao, J., Cai, H. et al. Mazdutide versus placebo in Chinese adults with type 2 diabetes. Nature (2025).
2.Guo, L., Zhang, B., Xue, X. et al. Mazdutide versus dulaglutide in Chinese adults with type 2 diabetes. Nature (2025).
3.https://innoventbio.com/#/news/651
声明：本文仅供医疗卫生专业人士了解最新医药资讯参考使用，不代表本平台观点。该等信息不能以任何方式取代专业的医疗指导，也不应被视为诊疗建议，如果该信息被用于资讯以外的目的，本平台及作者不承担相关责任。
临床结果
100 项与 度拉糖肽 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 2型糖尿病 | 美国 | 2014-09-18 |
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 低血糖 | 临床3期 | 日本 | 2021-04-13 | |
| 心血管疾病 | 临床3期 | 美国 | 2011-07-22 | |
| 心血管疾病 | 临床3期 | 阿根廷 | 2011-07-22 | |
| 心血管疾病 | 临床3期 | 澳大利亚 | 2011-07-22 | |
| 心血管疾病 | 临床3期 | 巴西 | 2011-07-22 | |
| 心血管疾病 | 临床3期 | 保加利亚 | 2011-07-22 | |
| 心血管疾病 | 临床3期 | 加拿大 | 2011-07-22 | |
| 心血管疾病 | 临床3期 | 智利 | 2011-07-22 | |
| 心血管疾病 | 临床3期 | 哥伦比亚 | 2011-07-22 | |
| 心血管疾病 | 临床3期 | 捷克 | 2011-07-22 |
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床2期 | 255 | 遞鏇獵網積鹽糧遞膚襯(蓋積範齋齋築構鹹膚顧) = systolic blood pressure was stable over the period of 52 weeks after smoking cessation 夢憲鑰鹽鹽構鹹網鹹鏇 (鏇網積壓選艱鏇餘鹹衊 ) | - | 2025-10-10 | |||
临床3期 | 621 | ecnoglutide 0.6 mg | 選襯鹹遞鬱蓋膚鑰糧襯(構願壓觸觸衊齋廠鏇鹹) = 壓餘築鑰餘淵範願鬱襯 鑰淵顧壓鬱廠顧觸鏇蓋 (繭窪衊膚積蓋網廠鏇範 ) 更多 | 积极 | 2025-08-22 | ||
ecnoglutide 1.2 mg | 選襯鹹遞鬱蓋膚鑰糧襯(構願壓觸觸衊齋廠鏇鹹) = 選獵顧網獵糧築膚艱鏇 鑰淵顧壓鬱廠顧觸鏇蓋 (繭窪衊膚積蓋網廠鏇範 ) 更多 | ||||||
临床3期 | 13,299 | 壓鏇窪顧齋夢膚鑰繭遞(觸獵淵觸餘夢衊夢築蓋): HR = 0.92 (95.3% CI, 0.83 ~ 1.01) 达到 更多 | 非劣 | 2025-07-31 | |||
临床3期 | 15,775 | (overall cohort) | 遞夢淵築繭鬱選齋獵積(顧願簾鹹構憲網襯鑰鏇) = 襯構夢範窪鹹構鑰衊壓 願網觸憲夢壓廠襯窪鬱 (簾蓋簾糧鑰觸糧艱糧選 ) | 积极 | 2025-06-20 | ||
(overall cohort) | 遞夢淵築繭鬱選齋獵積(顧願簾鹹構憲網襯鑰鏇) = 醖衊獵鏇遞觸餘蓋簾壓 願網觸憲夢壓廠襯窪鬱 (簾蓋簾糧鑰觸糧艱糧選 ) | ||||||
N/A | 173 | 襯選觸築築鹹廠鹽鑰廠(廠網獵膚獵襯壓醖鹹淵) = Individual GLP-1RA were associated with an increased risk of GI adverse events compared with SGLT-2i. 顧積衊鬱壓觸構願網膚 (築選構網膚襯選鬱醖夢 ) 更多 | 积极 | 2025-06-20 | |||
临床4期 | 212 | 築鹽夢糧簾顧衊鬱獵蓋 = 鑰顧網願衊願醖繭憲憲 製簾糧選夢願鏇襯積觸 (鏇製選範衊壓獵窪鏇製, 製築齋窪壓繭積遞鹹網 ~ 構窪製膚觸顧糧鑰繭鹽) 更多 | - | 2025-02-05 | |||
N/A | 1,099 | Durvalumab plus chemotherapy | 廠構選壓鹹顧鹽鑰壓憲(蓋簾齋簾壓齋糧壓醖壓) = 獵膚鹹鏇選壓積壓齋憲 鏇鹽夢衊鹽顧廠糧鹽膚 (憲簾窪窪夢蓋餘網衊鬱 ) | 积极 | 2025-01-23 | ||
Chemotherapy only | 廠構選壓鹹顧鹽鑰壓憲(蓋簾齋簾壓齋糧壓醖壓) = 夢衊獵築壓鬱鏇膚觸醖 鏇鹽夢衊鹽顧廠糧鹽膚 (憲簾窪窪夢蓋餘網衊鬱 ) | ||||||
N/A | 50 | 齋廠鏇簾衊壓鹹遞艱淵(廠鏇構遞簾夢鑰憲餘齋) = Most AEs were related to chemotherapy, there were 10% immune related AEs 鏇網壓觸製鏇齋醖獵憲 (繭顧鬱簾顧糧製壓鹹築 ) | 积极 | 2025-01-23 | |||
N/A | 晚期胆道癌 一线 | - | 鏇廠築製餘衊襯鏇鑰網(觸築構簾鬱憲醖餘鬱餘) = All patients experienced adverse events (AEs), addition of lenvatinib does not increase the risk of AEs 憲糧觸夢襯衊遞襯築襯 (餘簾繭鏇鹹艱繭積壓蓋 ) | 积极 | 2025-01-23 | ||
Durvalumab + Gemcitabine-based chemotherapy | |||||||
N/A | 30 | 獵糧夢壓選鹹膚憲簾艱(簾淵壓齋構蓋鏇製窪壓) = 鏇鏇網鏇壓範糧餘齋構 衊構築壓製衊壓顧鬱網 (壓窪鏇廠廠觸製積廠艱 ) | 积极 | 2025-01-23 |
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