预约演示
更新于：2025-08-06
Cyanocobalamin
维生素B12
更新于：2025-08-06
概要
基本信息
原研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1967-03-24), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C63H88CoN14O14P |
InChIKeyDLRXOSFAWIKARM-SYUKHSAKSA-M |
CAS号68-19-9 |
关联
157
项与 维生素B12 相关的临床试验NCT06966856
Sublingual Versus Oral Vitamin B12 for Acute Hypovitaminosis B12 Secondary to Proton Pump Inhibitors: A Prospective Randomized Study
CTRI/2025/06/088909
Comparing the efficacy of oral versus injectable vitaminB12 in patients with Neurocutaneous Infantile VitaminB12 deficiency Syndrome (NIBS): A RandomizedControlled Trial - NIL
CTRI/2025/06/089254
Comparison of high dose vitamin B12 versus standard dose vitamin B12 supplementation in preterm neonates born at 28 to 33 weeks of gestation- a randomized controlled trial - NIL
100 项与 维生素B12 相关的临床结果
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100 项与 维生素B12 相关的转化医学
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100 项与 维生素B12 相关的专利（医药）
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43,547
项与 维生素B12 相关的文献（医药）2025-12-31RENAL FAILURE
Healthy Eating Index-2015, a protective factor for mitochondria-derived methylmalonic acid in the low poverty/income ratio with chronic kidney diseases: results from NHANES 2011–2014
Article
作者: Lin, Tao ; Zhang, Hao ; Yang, Yaqing ; Bai, Yunjin ; Xiao, Yunfei ; Wang, Jia
OBJECTIVE:
Serum methylmalonic acid (MMA) arises from impaired metabolism of methylmalonyl-CoA and is exacerbated in chronic kidney disease (CKD) due to reduced renal clearance and nutritional deficiencies. The quality of diet may influence MMA levels by affecting vitamin B12 intake and mitigating inflammatory dietary components. This study aims to explore the relationship between the Healthy Eating Index-2015 (HEI-2015) and the prevalence of high MMA among low poverty/income ratio (PIR) patients with CKD.
METHOD:
We conducted a cross-sectional study of participants aged ≥20 years using the data drawn from the NHANES 2011-2014. Individuals under low PIR suffering from CKD were included. HEI-2015 was calculated to evaluate diet quality. Multivariable logistic regression models were applied to examine the association between HEI-2015 and high MMA prevalence with covariates adjusted. Stratified and interaction analysis were also performed.
RESULTS:
A total of 582 CKD patients with low PIR were enrolled. The logistic analysis showed that higher HEI-2015 was significantly associated with a lower prevalence of high MMA. Patients in the highest quartile of HEI-2015 scores (>61.17) showed a 57.8% reduction in high MMA prevalence compared to those in the lowest quartile. Subgroup and interaction analysis revealed that alcohol consumption reduced the diet quality-related protection against high MMA.
CONCLUSION:
The protective role of high-quality diets, as reflected by HEI-2015, in reducing the prevalence of high MMA in low PIR CKD patients is noteworthy. Improving diet quality in this population could potentially mitigate the risks associated with high MMA in CKD patients with low PIR.
2025-12-31Journal of Maternal-Fetal & Neonatal Medicine
Assessing the relationship between serum vitamin A, C, E, D, and B12 levels and preeclampsia
Article
作者: Hu, Zhenhua ; Yang, Wenjiao ; Gu, Weirong
OBJECTIVE:
Micronutrients play an important role in maintaining physiological functions while preventing complications associated with pregnancy. The main aim of this study was to evaluate the possible associations between vitamins A, C, D, E, B12, and preeclampsia using a retrospective analytical approach.
METHODS:
This retrospective study enrolled pregnant women who attended routine antenatal checkups between January 2021 and January 2023 at the Obstetrics and Gynecology Hospital of Fudan University. One thousand pregnant women aged 18-50 years whose serum vitamin assessments were conducted during 12-20 weeks of gestation were enrolled. Inclusion criteria: women with preeclampsia, singleton pregnancies, and no previous history of hypertension or preeclampsia. Exclusion criteria: metabolic disorders, multiple pregnancies, and other specified exclusions. Approval of the hospital's ethics committee; all participants gave written informed consent. Demographic data analyzed include age, BMI, and gestational age, showing no significant differences in age span between groups (p > .05).
RESULTS:
In the preeclampsia group, the serum level of vitamin A stands at 1.08 ± 0.29 μmol/L, which is lower than the control group of 1.13 ± 0.31 μmol/L (p < .05). Mean serum levels of vitamin C in preeclampsia are 51.81 ± 13.15 μmol/L, which was lower than in the control group, where it was 59.67 ± 16.40 μmol/L (p < .05). The mean serum vitamin B12 level in preeclampsia is 158.28 ± 46.77 pmol/L, lower than the 165.61 ± 40.99 pmol in the control group (p < .05). The two groups had no significant difference in serum vitamin E and vitamin D levels (p > .05).
CONCLUSION:
Serum vitamins A, C, and B12 at 12 to 20 weeks of pregnancy might be important predisposing factors for preeclampsia. They can be used as indicators of preeclampsia severity and offer clinical detection even before the patient presents with symptoms.
2025-12-01Genes and Nutrition
Exploring causal relationships between circulating micronutrients and age-related eye diseases: a Mendelian randomization study
Article
作者: Cao, Xiang ; Yuan, Xiaoyong ; Zhang, Boyang ; Xu, Zijiao ; Jiang, Zhixin
BACKGROUND:
With the global population aging, age-related eye diseases (AREDs) such as senile cataract (SC), age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy (DR) are becoming increasingly significant public health concerns. The rising prevalence of AREDs underscores the urgent need for effective prevention and treatment strategies. This study aimed to explore the causal relationships between circulating micronutrients (CMs) and AREDs.
METHODS:
A bidirectional two-sample Mendelian randomization (MR) analysis was conducted using genetic variants as instrumental variables to assess the effects of fifteen CMs (vitamin A, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, folate, carotene, copper, calcium, iron, magnesium, potassium, selenium, zinc) on AREDs. Data were sourced from large-scale genome-wide association studies (GWAS). The primary analytical method employed was inverse-variance weighted (IVW), supplemented by sensitivity analyses to confirm the robustness of the results.
RESULTS:
The MR analysis revealed significant protective effects of selenium against SC (OR = 0.961, 95% CI = 0.932-0.991, P = 0.012) and DR (OR = 0.927, 95% CI = 0.870-0.987, P = 0.019). Furthermore, higher genetically predicted magnesium levels were associated with a reduced risk of AMD (OR = 0.679, 95% CI = 0.515-0.895, P = 0.006). However, no significant causal relationships were observed between the other CMs and glaucoma or other AREDs.
CONCLUSIONS:
These findings provided valuable insights into the complex interplay between CMs and AREDs, offering potential pathways for developing targeted nutritional interventions and public health strategies to mitigate the risk of these debilitating conditions.
100 项与 维生素B12 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 急性心肌梗塞 | 澳大利亚 | 2006-07-27 | |
| 心脏衰竭 | 澳大利亚 | 2006-07-27 | |
| 高血压 | 澳大利亚 | 2006-07-27 | |
| 恶性贫血 | 美国 | 2005-01-31 | |
| 维生素B12缺乏症 | 中国 | 1981-01-01 | |
| 视疲劳 | 日本 | 1967-03-24 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 脑梗塞 | 临床3期 | 美国 | 1996-09-01 | |
| 心肌梗塞 | 临床3期 | 美国 | 1996-09-01 | |
| 蛛网膜下腔出血 | 临床前 | 土耳其 | 2025-05-15 | |
| 天使综合征 | 临床前 | 美国 | 2011-12-01 | |
| 天使综合征 | 临床前 | 美国 | 2011-12-01 | |
| 天使综合征 | 临床前 | 美国 | 2011-12-01 |
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临床结果
临床结果
适应症
分期
评价
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临床1/2期 | 50 | 膚鏇範淵蓋夢構醖蓋蓋 = 憲顧鑰網廠網醖鑰選鬱 醖選願襯鹹觸築築糧鏇 (醖範觸廠餘襯鬱淵鏇鹽, 憲齋夢獵鑰憲衊壓獵餘 ~ 鏇鹽觸顧簾遞壓窪鹽廠) 更多 | - | 2018-01-19 | |||
N/A | - | Combined vitamin B-12 and balanced protein-energy supplementation (M+B-12 group) | 簾範憲鏇夢範顧齋積網(範遞鬱淵餘壓夢範獵鹽) = 膚廠構範襯顧選鑰製廠 顧製淵繭築獵壓齋膚蓋 (遞齋顧醖膚網觸積觸膚 ) | - | 2017-06-01 | ||
Combined vitamin B-12 and balanced protein-energy supplementation (M+P group) | 簾範憲鏇夢範顧齋積網(範遞鬱淵餘壓夢範獵鹽) = 壓醖膚淵衊廠獵繭窪鏇 顧製淵繭築獵壓齋膚蓋 (遞齋顧醖膚網觸積觸膚 ) | ||||||
N/A | - | 76 | Vitamin B-12-fortified toothpaste (Placebo) | 觸獵願積鑰夢膚艱鹹製(鹽鬱觸顧夢窪繭顧範觸) = 淵醖齋壓蓋簾網廠淵遞 鑰鏇範糧築簾廠鏇齋繭 (齋選襯夢構遞廠鹹觸淵 ) 更多 | - | 2017-03-01 | |
Vitamin B-12 toothpaste | 觸獵願積鑰夢膚艱鹹製(鹽鬱觸顧夢窪繭顧範觸) = 窪遞艱鹽鹹壓襯積構範 鑰鏇範糧築簾廠鏇齋繭 (齋選襯夢構遞廠鹹觸淵 ) 更多 | ||||||
N/A | 281 | 鹽鹹鑰壓構觸廠夢襯網(鬱夢鬱獵憲夢壓觸廠顧) = 構淵鏇糧積窪鑰顧襯積 網憲鑰積齋艱醖鑰憲築 (顧繭積蓋遞遞廠鹹齋膚 ) | 积极 | 2016-05-20 | |||
鹽鹹鑰壓構觸廠夢襯網(鬱夢鬱獵憲夢壓觸廠顧) = 衊願艱願顧顧網繭鹹鏇 網憲鑰積齋艱醖鑰憲築 (顧繭積蓋遞遞廠鹹齋膚 ) | |||||||
N/A | 132 | 憲憲製鬱廠衊鹹選蓋糧(積窪艱蓋鑰膚醖憲衊窪) = 積窪觸壓獵鬱衊繭廠膚 夢築憲遞簾醖壓壓鏇選 (憲築遞鬱鹽網簾膚簾艱, 41,902) 更多 | - | 2014-09-08 | |||
N/A | 90 | 製窪蓋憲鬱醖繭鹽蓋廠(築壓鑰繭鏇齋選餘構餘) = 膚餘顧鹽獵蓋積齋鹽鏇 積膚願衊積膚醖築鹽醖 (觸艱襯觸醖鹹窪觸衊鹽, 7.8) 更多 | - | 2012-09-24 | |||
(Treatment (Metafolin/Creatine/Betain/B12)) | 鏇獵醖齋齋廠淵願築觸(網鬱觸範淵壓艱獵窪網) = 製夢範膚簾鹹築艱製鬱 憲願鹹鑰衊簾鬱構鏇壓 (顧鹽構衊鹹遞鏇襯壓鹽, 224.5) 更多 |
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