预约演示
更新于：2025-07-19
Bisoprolol Fumarate
富马酸比索洛尔
更新于：2025-07-19
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 (1986-01-01), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C40H66N2O12 |
InChIKeyVMDFASMUILANOL-WXXKFALUSA-N |
CAS号104344-23-2 |
关联
61
项与 富马酸比索洛尔 相关的临床试验NCT04432610
Echocardiographic Study of a Single Dose Bisoprolol Versus Nebivolol in Healthy Subjects: a Randomized, Double-blind, Cross-over Study
CTR20251268
富马酸比索洛尔片在空腹和餐后条件下的人体生物等效性试验
NCT07029906
pErsonalised Nocebo Assessment of Beta-blockEr Symptoms in Heart Failure
100 项与 富马酸比索洛尔 相关的临床结果
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100 项与 富马酸比索洛尔 相关的转化医学
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100 项与 富马酸比索洛尔 相关的专利（医药）
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2,966
项与 富马酸比索洛尔 相关的文献（医药）2025-09-01ENVIRONMENTAL POLLUTION
Pharmaceuticals in coastal sediments: validation of an ultra-high-performance liquid chromatography coupled with time-of-flight mass spectrometry (UHPLC-TOF-MS) methodology
Article
作者: Pardal, Miguel A ; Leston, Sara ; Ramos, Fernando ; Leite, Marta ; Freitas, Andreia ; Cenáculo, Diogo ; Bessa, Filipa
Pharmaceutical contamination in coastal and marine sediments is an increasing environmental issue. Thousands of biologically active substances continuously enter aquatic ecosystems through wastewater discharge, agricultural runoff, and improper disposal. Due to their persistence and continuous release, these contaminants accumulate in various matrices, including water and sediments, posing long-term ecological risks. Their presence can disrupt microbial communities, bioaccumulate in marine organisms, and heighten the risks of chronic exposure and antimicrobial resistance. To safeguard human, animal, and environmental health, it is crucial to develop accurate methodologies to understand pharmaceutical occurrence profiles and monitor their presence in coastal ecosystems. This study describes the development and validation of a sensitive UHPLC-TOF-MS method for screening and confirming pharmaceuticals in coastal sediments, following Commission Implementing Regulation (EU) 2021/808. Thirty analytes were targeted and evaluated for key performance parameters, including selectivity and sensitivity, linearity, repeatability, reproducibility, trueness, limit of detection (LOD), and limit of quantification (LOQ). Data analysis demonstrated high selectivity and sensitivity, with LODs ranging from 0.02 to 0.23 ng/g and LOQs from 0.06 to 0.69 ng/g. Recovery values at the LOD level ranged from 74.3 % for irbesartan to 115.4 % for indapamide, while repeatability and reproducibility were under 19.5 % and 29.2 %, respectively. All performance criteria met the requirements outlined in European guidelines. To evaluate the method's robustness, it was applied to 12 sediment samples collected from an estuary, with irbesartan detected in 5 samples.
2025-09-01AQUATIC TOXICOLOGY
Contamination of water with drugs - the response of phytoplankton
Article
作者: Krawczyk, Barbara ; Kaźmierczak, Andrzej ; Szczukocki, Dominik ; Czarny-Krzymińska, Karolina
Human xenobiotic emissions exert a notable effect on aquatic organisms. However, there is a paucity of information concerning the chronic effects of drugs on aquatic microorganisms. Furthermore, the majority of studies to date have considered the toxicity of individual compounds in isolation rather than in complex mixtures found in the environment. The present investigation sought to assess the chronic impact of amoxicillin, bisoprolol, diclofenac, ketoprofen, sulfadiazine, and tramadol on three species of aquatic primary producers: Chlorella vulgaris, Desmodesmus armatus, and Trichormus variabilis for both individual compounds and their mixture. The obtained findings demonstrated significant inhibition of the growth of all tested strains, alteration in antioxidant enzyme activity, and morphological changes in their cells. The nature of the effects of the compounds in the tested mixture was additive. Furthermore, the ecological risk associated with exposure to the tested substances was assessed. The risk was determined to be high for ketoprofen and drugs mixture, medium for amoxicillin, diclofenac, and sulfadiazine, and low for bisoprolol and tramadol. The results of this study have revealed the ecotoxicological risks posed by the tested drugs to photosynthetic microorganisms, and have also offered insights into the biochemistry and cell morphology of the microorganisms in question. In addition, the findings of this study indicate that the exclusive reliance on the EC50 parameter in the evaluation of the impact of xenobiotics on non-target organisms represents a remarkably constrained approach. This is attributable to the fact that it fails to provide insight into the changes that occur at the cellular level.
2025-08-01JOURNAL OF HAZARDOUS MATERIALS
Assessing the chemical burden of the North-East Atlantic ecosystem through targeted and untargeted HRMS-based approaches
Article
作者: Berbee, Rob ; von der Ohe, Peter ; Munch Chistensen, Anne ; Koschorreck, Jan ; Larsen, Martin Mørk ; Mil-Homens, Mário ; Pirntke, Ulrike ; Vasilatos, Konstantinos ; Soerensen, Anne L ; McHugh, Brendan ; Hjermann, Dag Øystein ; Näslund, Johan ; Power, Andrew ; Parmentier, Koen ; Athanasopoulou, Antonia ; Thomaidis, Nikolaos S ; Kammann, Ulrike ; Mauffret, Aourell ; Webster, Lynda ; Wilson, Simon ; Oliveira, Susana Galante ; Alygizakis, Nikiforos ; Burgeot, Thierry ; Oswald, Peter ; Gustafsson, Johan ; Gkotsis, Georgios ; Kirchgeorg, Torben ; Slobodnik, Jaroslav ; Viñas, Lucia ; Campos, Alejandro Iglesias ; Van der Stap, Irene ; Barber, Jonathan L ; Nika, Maria-Christina
Human activities have introduced significant amounts of anthropogenic chemicals into marine ecosystems, posing threats to aquatic biodiversity and human health. Although, traditional marine monitoring focus primarily on legacy pollutants, the presence and potential risks associated with complex emerging chemical mixtures should not be neglected. In the context of the present study organized via OSPAR Commission and supported by NORMAN network, 52 marine samples were gathered from North-East Atlantic Ocean. State-of-the-art HRMS-based analytical workflows were employed to identify their chemical fingerprint. 132 organic pollutants were identified through wide-scope target screening of more than 2,400 environmentally relevant organic pollutants. The HRMS data were digitally stored in NORMAN DSFP and 134 additional chemicals were tentatively identified through suspect screening of more than 65,000 chemicals. The list included legacy pollutants, along with emerging pollutants, their metabolites and transformation products. A simplified environmental risk assessment was conducted, aiming to prioritize substances based on their potential risks to the marine ecosystem. This study provides a valuable snapshot of the marine pollution, offering insights into chemical occurrence and risks. The findings can support marine scientists, environmental managers and policymakers in identifying pollutant sources, understanding their impacts, and informing regulatory measures to mitigate threats to marine ecosystems.
100 项与 富马酸比索洛尔 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 心房颤动 | 日本 | 2013-06-14 | |
| 心动过速 | 日本 | 2013-06-14 | |
| 心脏衰竭 | 澳大利亚 | 2002-04-23 | |
| 高血压 | 美国 | 1992-07-31 | |
| 原发性高血压 | 日本 | 1990-09-28 | |
| 心绞痛 | - | 1986-01-01 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 43 | 蓋醖獵範願繭獵積遞醖 = 鏇憲獵鹹壓艱醖構齋繭 齋憲獵淵製廠餘遞鏇顧 (願齋餘繭遞鹹糧夢鏇選, 糧築觸壓繭襯選網獵襯 ~ 夢鹽淵範構製鬱獵夢繭) 更多 | - | 2022-03-10 | |||
蓋醖獵範願繭獵積遞醖 = 鏇製築積積蓋衊範夢醖 齋憲獵淵製廠餘遞鏇顧 (願齋餘繭遞鹹糧夢鏇選, 醖壓壓膚獵襯淵淵鬱醖 ~ 醖鏇糧鹹膚憲艱觸鑰繭) 更多 |
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