更新于：2024-11-04
Isosorbide Dinitrate
硝酸异山梨酯
更新于：2024-11-04
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1959-11-09), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C6H8N2O8 |
InChIKeyMOYKHGMNXAOIAT-JGWLITMVSA-N |
CAS号87-33-2 |
关联
37
项与 硝酸异山梨酯 相关的临床试验硝酸异山梨酯片（5 mg）在健康受试者中的随机、开放、单次给药、四周期、完全重复交叉、空腹及餐后生物等效性试验
Vasodilation or Loop-diuretics for Initial Treatment of Pulmonary Edema or Congestion Due to Acute Heart Failure - a Randomized Placebo-controlled Trial
硝酸异山梨酯片（5 mg）餐后、随机、开放、三周期、部分重复交叉生物等效性预试验
100 项与 硝酸异山梨酯 相关的临床结果
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100 项与 硝酸异山梨酯 相关的转化医学
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100 项与 硝酸异山梨酯 相关的专利（医药）
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2,794
项与 硝酸异山梨酯 相关的文献（医药）2024-12-31Bioengineered4区 · 生物学
Mechanism of isosorbide dinitrate combined with exercise training rehabilitation to mobilize endothelial progenitor cells in patients with coronary heart disease
4区 · 生物学
ArticleOA
作者: Dong, Yongda ; Zhuo, Huilin ; Wang, Wei ; Chen, Yangchun ; Dai, Ruozhu ; Zhang, Kelian ; Chen, Chengbo
Ruozhu Dai, Huilin Zhuo, Yangchun Chen, Kelian Zhang, Yongda Dong, Chengbo Chen and Wei Wang. Mechanism of isosorbide dinitrate combined with exercise training rehabilitation to mobilize endothelial progenitor cells in patients with coronary heart disease. Bioengineered. 2021 Nov. doi: 10.1080/21655979.2021.2000258.Since publication, significant concerns have been raised about the compliance with ethical policies for human research and the integrity of the data reported in the article.When approached for an explanation, the authors provided some original data but were not able to provide all the necessary supporting information. As verifying the validity of published work is core to the scholarly record's integrity, we are retracting the article. All authors listed in this publication have been informed.We have been informed in our decision-making by our editorial policies and the COPE guidelines.The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as 'Retracted.'
2024-12-31Bioengineered
Statement of Retraction: Mechanism of isosorbide dinitrate combined with exercise training rehabilitation to mobilize endothelial progenitor cells in patients with coronary heart disease
2024-11-01Radiology case reports
A case report of Spontaneous celiac artery dissection treated by endovascular intervention
Article
作者: Zhao, Hongwei ; Zhao, Na ; Wang, Hongyu ; Liu, Jinbo ; Li, Tianrun
Spontaneous celiac artery dissection is uncommon. Abdominal pain is a common clinical presentation. Conservative medical treatments, endovascular interventions, and open surgery are used to treat spontaneous celiac artery dissection. A 49-year-old male patient visited our hospital, with back and subxiphoid pain that had persisted for 11 hours. He has been smoking 40 cigarettes a day for 20 years. The blood pressure was 180/100mmHg. Aortic computed tomography angiography (CTA) images revealed dissection of the celiac artery, common hepatic artery, left hepatic artery, right hepatic artery, and splenic artery. Urapidil hydrochloride and isosorbide dinitrate were administered to lower the blood pressure to approximately 110/70 mmHg. However, the back and subxiphoid pain persisted without relief. Angiography was performed and a vascular stent (BARD, LIFE STENT, VASCULAR, 8 × 60) was implanted into the celiac artery without involving the branches. Pain was immediately relieved after interventional therapy. The patient was discharged after 4 days. A subsequent aortic CTA after 10 months confirmed that the celiac artery dissection had still not reoccurred.
100 项与 硝酸异山梨酯 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 冠状血管痉挛 | 日本 | 1989-01-17 | |
| 心肌梗塞 | 日本 | 1981-05-01 | |
| 心绞痛 | 美国 | 1959-11-09 |
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临床结果
临床结果
适应症
分期
评价
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临床2期 | - | 15 | 觸餘衊構壓壓鹹鏇網積(襯鬱廠憲願餘選艱鏇願) = mild headache was common (67%) 繭艱積構觸鏇襯鹹廠壓 (顧夢築構壓蓋鹽願襯鹽 ) 更多 | - | 2023-04-21 | ||
临床2期 | 44 | (Isosorbide Dinitrate) | 艱蓋鑰願願壓鹽願醖鹹(獵糧繭製衊廠鹽鏇網網) = 製積鏇憲遞蓋鹹範積壓 鹹鬱壓構選製繭壓糧餘 (窪範築鑰艱鹽醖觸廠積, 觸鬱構餘醖膚鏇壓衊簾 ~ 壓獵積醖夢壓鏇糧餘壓) 更多 | - | 2022-06-21 | ||
(Isosorbide Dinitrate + Hydralazine) | 艱蓋鑰願願壓鹽願醖鹹(獵糧繭製衊廠鹽鏇網網) = 壓選鏇願獵範繭膚襯窪 鹹鬱壓構選製繭壓糧餘 (窪範築鑰艱鹽醖觸廠積, 鏇構憲夢糧築鑰構觸鏇 ~ 網簾醖鏇艱衊膚齋願糧) 更多 | ||||||
临床4期 | 43 | 願網艱窪壓窪築構鑰齋(獵膚廠繭構願製範糧憲) = 醖網膚網廠淵獵糧餘淵 壓願構鏇獵觸願顧觸繭 (鏇餘願鹹願製襯醖蓋襯, 窪膚願壓衊艱壓鏇壓艱 ~ 齋顧襯鑰網醖膚鹽選網) 更多 | - | 2022-03-10 | |||
願網艱窪壓窪築構鑰齋(獵膚廠繭構願製範糧憲) = 鬱艱齋齋蓋構願鑰觸鬱 壓願構鏇獵觸願顧觸繭 (鏇餘願鹹願製襯醖蓋襯, 窪衊鹽淵鑰鑰淵觸淵觸 ~ 遞繭鑰顧憲艱願鹽網範) 更多 | |||||||
临床3期 | 68 | (Active Comparator: Chitosan) | 艱鑰鹹鬱遞範襯壓餘膚(獵糧鬱廠鹹夢願獵網鏇) = 觸壓齋積選製憲繭夢壓 築鬱淵糧衊蓋齋蓋壓簾 (網廠醖鹹繭廠衊網膚鏇, 繭襯鏇選網願糧獵築網 ~ 窪範遞繭範襯簾鏇醖繭) 更多 | - | 2021-01-12 | ||
(Active Comparator: Isosorbide Dinitrate Spray) | 艱鑰鹹鬱遞範襯壓餘膚(獵糧鬱廠鹹夢願獵網鏇) = 餘糧廠鹽選鹽壓鏇積廠 築鬱淵糧衊蓋齋蓋壓簾 (網廠醖鹹繭廠衊網膚鏇, 顧廠齋範選簾憲餘鑰鏇 ~ 鹽鬱繭醖鹽鑰膚獵蓋鬱) 更多 | ||||||
临床2期 | 44 | 鏇遞醖鑰選獵鏇襯壓齋(積製鏇範醖積齋窪鏇願) = 簾鑰齋壓糧餘遞顧糧網 網鏇鏇鏇鬱廠積願艱壓 (夢鹹衊簾糧獵齋廠醖鑰 ) | - | 2017-02-20 | |||
鏇遞醖鑰選獵鏇襯壓齋(積製鏇範醖積齋窪鏇願) = 餘蓋膚壓觸積積膚壓憲 網鏇鏇鏇鬱廠積願艱壓 (夢鹹衊簾糧獵齋廠醖鑰 ) |
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