更新于：2024-04-26
Aripiprazole
阿立哌唑
更新于：2024-04-26
概要
基本信息
简介阿立哌唑，商品名 Abilify Discmelt®，是一种非典型抗精神病药物，用于治疗多种情绪和精神病，包括但不限于精神分裂症、I 型双相情感障碍、重度抑郁症、易激惹相关疾病、自闭症和图雷特综合症。作用机制为5-HT2A 激动剂和 D2 受体激动剂。阿立哌唑于2002 年首次获得美国 FDA 批准，由大冢控股开发。它的主要适应症是用于治疗精神分裂症。 |
药物类型 小分子化药 |
别名 ABILIFY MAINTENA、Abilify MyCite、Abilify Prolonged Release Aqueous Suspension + [26] |
作用机制 5-HT1A receptor激动剂(5-羟色胺1A受体激动剂)、5-HT2A receptor拮抗剂(5-羟色胺2A受体拮抗剂)、D2 receptor激动剂(多巴胺D2受体激动剂) |
在研适应症 |
最高研发阶段批准上市 |
首次获批日期 美国 (2002-11-15), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国)、优先审评 (中国) |
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结构
分子式C23H27Cl2N3O2 |
InChIKeyCEUORZQYGODEFX-UHFFFAOYSA-N |
CAS号129722-12-9 |
关联
530
项与 阿立哌唑 相关的临床试验A Randomized Controlled Trial to Evaluate Atypical Antipsychotic-induced Mitochondrial Dysfunction in Patients With Schizophrenia
精神分裂症患者接受注射用阿立哌唑多次给药的随机、开放、交叉、稳态人体生物等效性研究
The Characteristics of Treatment Resistant Schizophrenia From the Illness Onset
100 项与 阿立哌唑 相关的临床结果
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100 项与 阿立哌唑 相关的转化医学
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100 项与 阿立哌唑 相关的专利（医药）
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5,363
项与 阿立哌唑 相关的文献（医药）2024-06-01IBRO Neuroscience Reports
Assessing remission in major depressive disorder using a functional-structural data fusion pipeline: A CAN-BIND-1 study
Article
作者: Hall, Geoffrey B ; Milev, Roumen ; Minuzzi, Luciano ; Kennedy, Sidney H ; Davis, Andrew D ; MacQueen, Glenda ; Harris, Jacqueline K ; Lam, Raymond W ; Rotzinger, Susan ; Alders, Gésine L ; Frey, Benicio N ; Hassel, Stefanie ; Zamyadi, Mojdeh ; Strother, Stephen C ; Ayyash, Sondos ; Arnott, Stephen R ; Müller, Daniel J
Neural network-level changes underlying symptom remission in major depressive disorder (MDD) are often studied from a single perspective. Multimodal approaches to assess neuropsychiatric disorders are evolving, as they offer richer information about brain networks. A FATCAT-awFC pipeline was developed to integrate a computationally intense data fusion method with a toolbox, to produce a faster and more intuitive pipeline for combining functional connectivity with structural connectivity (denoted as anatomically weighted functional connectivity (awFC)). Ninety-three participants from the Canadian Biomarker Integration Network for Depression study (CAN-BIND-1) were included. Patients with MDD were treated with 8 weeks of escitalopram and adjunctive aripiprazole for another 8 weeks. Between-group connectivity (SC, FC, awFC) comparisons contrasted remitters (REM) with non-remitters (NREM) at baseline and 8 weeks. Additionally, a longitudinal study analysis was performed to compare connectivity changes across time for REM, from baseline to week-8. Association between cognitive variables and connectivity were also assessed. REM were distinguished from NREM by lower awFC within the default mode, frontoparietal, and ventral attention networks. Compared to REM at baseline, REM at week-8 revealed increased awFC within the dorsal attention network and decreased awFC within the frontoparietal network. A medium effect size was observed for most results. AwFC in the frontoparietal network was associated with neurocognitive index and cognitive flexibility for the NREM group at week-8. In conclusion, the FATCAT-awFC pipeline has the benefit of providing insight on the 'full picture' of connectivity changes for REMs and NREMs while making for an easy intuitive approach.
2024-05-01Talanta
Solid phase microextraction device coupled with miniature mass spectrometry and mathematical model of its ion chronogram
Article
作者: Li, Jiwen ; Liang, Qiong ; Gu, Hao ; Xu, Wei
Modern solid phase microextraction (SPME) device linked with mass spectrometry (SPME-MS) has evolved from producing ion chronogram as flat noisy signal to as unimodal-like signal. We designed a SPME device, which is closer in morphology to LC column, linked it with a miniature mass spectrometer (SPME-Mini MS), and proposed a mathematical model that elution of compound from the SPME device is equivalent to overlay of elution of the compound from the infinite LC columns with the lengths between 0 and the length of the device and it can generate an ion chronogram as right-skew unimodal signal. Rhodamine B as analyte was used for experimental verification and its unimodal signal was used to fit the parameters of a computer simulation program based on the model. The experimental results and simulations empirically cross-confirmed that SPME-Mini MS can generate ion chronogram as clean right-skew unimodal signal. Furthermore, the SPME-Mini MS system was used for quantitative analysis of psychotropic drugs (i.e. risperidone and aripiprazole) in artificial urine. The results preliminarily demonstrated that the system can utilize area under unimodal signal for quantitative analysis and has potential to be applied for on-site, fast and accurate quantification of drugs and other compounds.
2024-05-01Legal Medicine
A suicide case of liquid nicotine intoxication
作者: Horioka, Kie ; Motomura, Ayumi ; Yajima, Daisuke ; Ishii, Namiko ; Moue, Chihiro ; Inoue, Hiroyuki ; Okaba, Keisuke ; Ohashi, Ryuto
A man in his 50 s, who was found vomiting and in a disturbed state when the emergency medical team arrived, then went into cardiopulmonary arrest during transport and died without responding to resuscitation. The hospital initially suspected that the death may have been caused by internal causes, but since the deceased had previously been transported to the hospital in a suicide attempt, the hospital called police regarding suspicions of unnatural death. The police investigation revealed two empty bottles of nicotine liquid for e-cigarettes in his house and a search history of "nicotine suicide" on his cellphone. In a forensic autopsy, he was found to be highly obese, and abundant fat deposits were observed in his organs. A stent was placed in the aorta, but no abnormality was found. There was no obvious stenosis or obstruction in the coronary arteries. Drug screening using liquid chromatography tandem mass spectrometry (LC-MS/MS) was performed on cardiac blood, urine, and stomach contents collected at autopsy, which revealed the presence of some medical products such as aripiprazole, nicotine, and cotinine. Further quantitative testing revealed high concentrations of nicotine in all samples. The left and right femoral venous blood concentrations were above the lethal dose, suggesting that arrhythmia or respiratory failure due to nicotine intoxication was the cause of death. With the widespread use of e-cigarettes, high concentrations of nicotine are readily available, and case reports of serious nicotine addiction are increasing. It is important to always consider addiction when conducting forensic evaluations in the medical field.
100 项与 阿立哌唑 相关的药物交易
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研发状态
| 适应症 | 最高研发状态 | 国家/地区 | 公司 |
|---|---|---|---|
| 躁郁症1型 | 批准上市 | 挪威 更多 | |
| 精神分裂症 | 批准上市 | 挪威 更多 | |
| Tourette 综合征 | 批准上市 | 美国 更多 | |
| 躁狂 | 终止 | 美国 更多 | |
| 精神障碍 | 终止 | 罗马尼亚 更多 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床1/2期 | 266 | (Aripiprazole 2M LAI 960 mg: Schizophrenia or Bipolar I Disorder) | 觸廠蓋選憲積簾網選夢(遞淵齋鏇顧築繭夢積鬱) = 窪餘鑰製獵觸鹹鑰壓淵 蓋積齋選選鹽夢簾積簾 (衊繭鹽壓廠鬱遞築鬱構, 簾鑰壓遞築構遞夢鬱鬱 ~ 壓餘襯選衊蓋齋窪齋醖) 更多 | - | 2023-11-18 | ||
(Aripiprazole IM Depot 400 mg: Schizophrenia or Bipolar I Disorder) | 觸廠蓋選憲積簾網選夢(遞淵齋鏇顧築繭夢積鬱) = 觸壓願憲鹽簾獵醖醖鹹 蓋積齋選選鹽夢簾積簾 (衊繭鹽壓廠鬱遞築鬱構, 選鑰顧網糧選範鬱壓襯 ~ 鹽選鏇壓齋糧夢願獵糧) 更多 | ||||||
临床4期 | 9 | (Aripiprazole) | 積網餘範齋膚製蓋範夢(願淵夢顧餘構願遞獵製) = 觸鏇齋襯蓋積襯鑰鏇鏇 壓觸齋窪憲顧簾壓衊糧 (構選獵簾窪獵壓構淵蓋, 鹹膚蓋廠簾餘夢淵鹹鹽 ~ 構鬱選鬱夢鏇鏇鑰齋鬱) 更多 | - | 2023-11-15 | ||
(Fluoxetine) | 積網餘範齋膚製蓋範夢(願淵夢顧餘構願遞獵製) = 遞鹽網鬱壓積網顧糧窪 壓觸齋窪憲顧簾壓衊糧 (構選獵簾窪獵壓構淵蓋, 壓製製選願艱夢糧觸願 ~ 範餘鏇簾膚顧齋艱糧窪) 更多 | ||||||
临床1/2期 | 266 | 膚廠繭膚艱積獵遞膚夢(鹹繭獵獵簾餘壓鏇鹽鏇) = 積膚築鬱繭構襯積壓鬱 鬱膚願夢餘築遞淵鏇鬱 (鏇齋蓋衊觸願艱夢齋糧 ) 更多 | - | 2023-06-09 | |||
膚廠繭膚艱積獵遞膚夢(鹹繭獵獵簾餘壓鏇鹽鏇) = 鬱憲襯壓糧襯蓋齋膚淵 鬱膚願夢餘築遞淵鏇鬱 (鏇齋蓋衊觸願艱夢齋糧 ) 更多 | |||||||
FDA 人工标引  | N/A | 339 | 範鬱網築艱願鑰糧簾鑰(餘鬱膚觸築憲窪憲範窪) = 鹽積膚鹽糧淵窪憲遞範 觸繭憲簾膚製壓壓構鑰 (襯構壓糧醖積構憲鹽夢, 1.6) | 积极 | 2023-04-27 | ||
Placebo | 範鬱網築艱願鑰糧簾鑰(餘鬱膚觸築憲窪憲範窪) = 願壓築繭鑰齋糧襯網遞 觸繭憲簾膚製壓壓構鑰 (襯構壓糧醖積構憲鹽夢, 1.6) | ||||||
临床4期 | 742 | (Aripiprazole Augmentation) | 壓鹽網願繭蓋構齋選糧(廠鬱鹹廠膚膚窪範廠積): P-Value = 0.650 更多 | - | 2022-05-24 | ||
(Bupropion Augmentation) | |||||||
临床4期 | 30 | 顧獵製醖願觸範觸膚築(壓範繭齋鹽鏇淵餘構壓) = 鏇觸膚簾積憲淵鑰壓顧 醖網餘糧衊積夢壓夢壓 (淵願膚鹹夢壓糧鏇鏇願, 構糧選顧觸鑰築齋選憲 ~ 獵獵積鹽鏇積壓網鑰窪) 更多 | - | 2022-02-17 | |||
N/A | 13 | (Aripiprazole) | 願膚餘獵鏇衊構廠淵鏇(顧衊構遞糧遞繭蓋窪襯) = 醖鹽窪獵遞構獵糧憲選 蓋淵遞鹽蓋鑰積願網衊 (鑰齋顧製製襯鹹繭構製, 衊獵淵糧製憲鹹鬱鹹鏇 ~ 願構衊壓膚鬱襯憲壓淵) 更多 | - | 2022-01-14 | ||
Placebos (Placebo) | 願膚餘獵鏇衊構廠淵鏇(顧衊構遞糧遞繭蓋窪襯) = 願齋獵選衊遞鏇醖憲獵 蓋淵遞鹽蓋鑰積願網衊 (鑰齋顧製製襯鹹繭構製, 構鹽製繭夢選鹹壓齋遞 ~ 積顧繭壓簾願構廠憲壓) 更多 | ||||||
临床3期 | 173 | (Prior Aripiprazole/Escitalopram Combination Therapy) | 製齋齋願衊鬱積觸獵築(積築鹹範製艱窪積鬱餘) = 鏇選壓淵築獵積憲製範 鹽選繭壓網構顧築選壓 (憲淵築觸糧醖選製憲鬱, 夢衊廠醖願憲觸製構衊 ~ 鑰築壓廠齋廠網襯製淵) 更多 | - | 2021-12-22 | ||
(Prior Escitalopram) | 製齋齋願衊鬱積觸獵築(積築鹹範製艱窪積鬱餘) = 構齋衊構蓋鑰襯獵範鹹 鹽選繭壓網構顧築選壓 (憲淵築觸糧醖選製憲鬱, 製網簾範襯醖願齋顧獵 ~ 膚蓋淵鬱鬱製壓鹽鹹構) 更多 | ||||||
临床3期 | 137 | (Phase C: Aripiprazole/Escitalopram Combination) | 顧選廠糧遞襯襯繭積觸(齋餘獵鹹願鏇衊鏇繭淵) = 膚窪構遞窪夢襯蓋網鏇 憲蓋鏇願網網艱積簾糧 (糧遞獵鏇鏇積鬱遞鹹齋, 齋膚遞簾鏇衊顧憲簾鬱 ~ 築醖夢繭壓製膚衊齋範) 更多 | - | 2021-12-21 | ||
(Phase C: Escitalopram Monotherapy) | 顧選廠糧遞襯襯繭積觸(齋餘獵鹹願鏇衊鏇繭淵) = 夢觸構鹹願鑰顧鬱醖網 憲蓋鏇願網網艱積簾糧 (糧遞獵鏇鏇積鬱遞鹹齋, 壓繭範選窪遞鑰糧顧範 ~ 鑰壓鹽鏇夢繭製築顧醖) 更多 | ||||||
临床4期 | - | 30 | 鹹艱醖積衊獵範鏇鏇積(範餘膚鏇顧網艱築製醖) = 繭蓋鏇觸夢獵鏇齋網鏇 襯網廠淵鹽遞築糧範餘 (獵觸遞鹹夢壓窪壓窪鏇, 糧顧壓築鬱醖齋淵夢簾 ~ 壓鬱廠廠鹹獵願構鏇齋) 更多 | - | 2021-10-26 |
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