预约演示
更新于：2026-06-11
Meningococcal group B vaccine(GlaxoSmithKline Biologicals SA)
B群脑膜炎球菌疫苗(Novartis Pharma AG)
更新于：2026-06-11
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 欧盟 (2013-01-13), |
最高研发阶段(中国)临床申请 |
特殊审评- |
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结构/序列
Sequence Code 6741
Sequence Code 23917
Sequence Code 58469
关联
71
项与 B群脑膜炎球菌疫苗(Novartis Pharma AG) 相关的临床试验NCT07252804
Short- and Long-Term Immunogenicity and Safety of Meningococcal Group B Vaccine in Children and Adolescents With Autoimmune Rheumatic Diseases
The goal of this clinical trial is to evaluate the humoral immunogenicity of the meningococcal B vaccine (MenB-4C) in pediatric patients with autoimmune rheumatic diseases (ARDs), compared to age- and sex-matched non-immunosuppressed controls.
The main questions it aims to answer are:
* To assess the influence of treatment on the response to the MenB-4C vaccine in patients with ARDs;
* To evaluate the impact of the MenB-4C vaccine on disease activity in patients with ARDs;
* To evaluate the safety of the MenB-4C vaccine in pediatric patients with ARDs and controls.
* To evaluate the association between physical activity levels and immunogenicity after vaccination.
Participants will:
Receive the MenB-4C vaccine (Bexsero©), administered intramuscularly in the deltoid muscle, in a 2-dose schedule (0.5 mL each), 1 month apart.
All participants will have blood samples collected immediately before vaccination at the baseline visit (D0), then receive the first vaccine dose on the same day (D0). The second dose will be administered 4 weeks after the first dose (D28). Blood samples will be collected on D0, D28, and D56. A final sample will be collected one year after the last dose (D208) to evaluate the persistence of immune response.
At study entry and one month after each dose, patients will also be assessed for clinical and laboratory disease activity using disease-specific indices and scores.
* Juvenile Systemic lupus erythematosus (JSLE): Systemic lupus erythematosus disease activity index 2000 (SLEDAI-2K) (CBC, anti-dsDNA, complement, urinalysis, protein/creatinine ratio)
* Juvenile Idiopatic Arthritis (JIA): Juvenile Arthritis Disease Activity Score (JADAS) (ESR, CRP)
* Juvenile dermatomyositis (JDM): Manual Muscle Testing (MMT) e Childhood Myositis Assessment Scale (CMAS): (CPK, transaminases, LDH)
Researcher will also perform analysis in:
Humoral immunogenicity will be assessed using serum bactericidal activity (SBA) assay with exogenous complement (baby rabbit, Pel Freez) against four test strains: H44/76 (fHBP), 5/99 (NadA), NZ98/254 (PorA), and M10713 (NHBA), from blood samples collected at D0, D28, D56, and D208. SBA assays will be conducted at the Immunology Center of the Adolfo Lutz Institute, São Paulo. Exogenous complement will be added to serially diluted serum samples, followed by the addition of a bacterial suspension. The humoral response rate induced by the vaccine, or seroconversion, will be defined by the bactericidal titer (the dilution that results in 50% bacterial killing within 60 minutes compared to the control), with titers ≥ 1:4 considered bactericidal. The geometric mean titers will be calculated using the exponential of the mean of the log-transformed concentrations.
Immunosuppressive treatments (NSAIDs, prednisone/prednisolone, intra-articular steroids, hydroxychloroquine, methotrexate, azathioprine, leflunomide, cyclosporine, tacrolimus, mycophenolate mofetil, and biologics [anti-TNF, tocilizumab, abatacept, belimumab, rituximab]) will be recorded sistematicaly.
Physical activity levels will be assessed using validated, age-appropriate methods.
The main questions it aims to answer are:
* To assess the influence of treatment on the response to the MenB-4C vaccine in patients with ARDs;
* To evaluate the impact of the MenB-4C vaccine on disease activity in patients with ARDs;
* To evaluate the safety of the MenB-4C vaccine in pediatric patients with ARDs and controls.
* To evaluate the association between physical activity levels and immunogenicity after vaccination.
Participants will:
Receive the MenB-4C vaccine (Bexsero©), administered intramuscularly in the deltoid muscle, in a 2-dose schedule (0.5 mL each), 1 month apart.
All participants will have blood samples collected immediately before vaccination at the baseline visit (D0), then receive the first vaccine dose on the same day (D0). The second dose will be administered 4 weeks after the first dose (D28). Blood samples will be collected on D0, D28, and D56. A final sample will be collected one year after the last dose (D208) to evaluate the persistence of immune response.
At study entry and one month after each dose, patients will also be assessed for clinical and laboratory disease activity using disease-specific indices and scores.
* Juvenile Systemic lupus erythematosus (JSLE): Systemic lupus erythematosus disease activity index 2000 (SLEDAI-2K) (CBC, anti-dsDNA, complement, urinalysis, protein/creatinine ratio)
* Juvenile Idiopatic Arthritis (JIA): Juvenile Arthritis Disease Activity Score (JADAS) (ESR, CRP)
* Juvenile dermatomyositis (JDM): Manual Muscle Testing (MMT) e Childhood Myositis Assessment Scale (CMAS): (CPK, transaminases, LDH)
Researcher will also perform analysis in:
Humoral immunogenicity will be assessed using serum bactericidal activity (SBA) assay with exogenous complement (baby rabbit, Pel Freez) against four test strains: H44/76 (fHBP), 5/99 (NadA), NZ98/254 (PorA), and M10713 (NHBA), from blood samples collected at D0, D28, D56, and D208. SBA assays will be conducted at the Immunology Center of the Adolfo Lutz Institute, São Paulo. Exogenous complement will be added to serially diluted serum samples, followed by the addition of a bacterial suspension. The humoral response rate induced by the vaccine, or seroconversion, will be defined by the bactericidal titer (the dilution that results in 50% bacterial killing within 60 minutes compared to the control), with titers ≥ 1:4 considered bactericidal. The geometric mean titers will be calculated using the exponential of the mean of the log-transformed concentrations.
Immunosuppressive treatments (NSAIDs, prednisone/prednisolone, intra-articular steroids, hydroxychloroquine, methotrexate, azathioprine, leflunomide, cyclosporine, tacrolimus, mycophenolate mofetil, and biologics [anti-TNF, tocilizumab, abatacept, belimumab, rituximab]) will be recorded sistematicaly.
Physical activity levels will be assessed using validated, age-appropriate methods.
开始日期2026-02-19 |
NCT06995430
A Phase 3b, Open-Label, Multi-Center Study to Assess the Immune Response And Safety of The Meningococcal Group B Vaccine Rmenb+Omv Nz When Administered to Healthy Participants Aged 10 To 20 Years Old, Who Were Primed During the First 2 Years Of Life
The main purpose of this study is to evaluate the immune response and safety of a booster dose of the meningococcal group B vaccine, rMenB+OMV NZ (also known as Bexsero), in adolescents and young adults aged 10 to 20 years. This study focuses on individuals who were first vaccinated with rMenB+OMV NZ as infants. The primary hypothesis is that a booster dose of the vaccine will elicit a stronger immune response in these primed individuals compared to those who have never received any group B meningococcal vaccine, referred to as 'nave' participants.
开始日期2025-07-07 |
申办/合作机构 |
ACTRN12623000738628
VIRGo – Vaccine-induced Immune Responses against Gonorrhoea: A study to investigate immune response induced by the 4CMenB vaccine against gonorrhoea in healthy adults
开始日期2025-06-10 |
申办/合作机构 |
100 项与 B群脑膜炎球菌疫苗(Novartis Pharma AG) 相关的临床结果
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100 项与 B群脑膜炎球菌疫苗(Novartis Pharma AG) 相关的转化医学
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100 项与 B群脑膜炎球菌疫苗(Novartis Pharma AG) 相关的专利（医药）
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358
项与 B群脑膜炎球菌疫苗(Novartis Pharma AG) 相关的文献（医药）2026-08-01·INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Do the protein-based meningococcal group B vaccines, 4CMenB and MenB-fHbp, elicit serum bactericidal antibody against meningococcal serogroup X clonal complex 181?
Article
作者: Clark, Stephen A ; Ali, Haleema ; Townsend-Payne, Kelly ; Linley, Ezra ; Mabey, Lesley ; Hill, Emma ; Borrow, Ray ; Basta, Nicole E
OBJECTIVES:
Bexsero (4CMenB) and Trumenba (MenB-fHbp) were designed and licensed to protect against meningococcal serogroup B disease; however, the antigens in these vaccines are shared among other meningococcal serogroups. This study assessed the immunogenicity of the two licensed serogroup B vaccines against a hyperinvasive serogroup X strain.
METHODS:
Sera from adults immunized with either 4CMenB (before and after one, two, or three doses of vaccine) or MenB-fHbp (before and after two doses) were assayed in the serum bactericidal antibody (SBA) assay against serogroup X strain BF 2/97.
RESULTS:
A four-fold increase in SBA titers was observed in 70.0% (95% confidence interval: 45.7-88.1) and 51.5% (95% confidence interval: 41.3-61.6) of subjects after 2 doses of 4CMenB and MenB-fHbp, respectively. A significant increase in SBA geometric mean titers and percentage of subjects with SBA titers greater than or equal to four from baseline to after two doses of both serogroup group B vaccines was observed.
CONCLUSION:
These data provide evidence that the licensed serogroup B vaccines can induce bactericidal antibodies against serogroup X, but it is noted the optimal control for serogroup X would be use of a conjugate vaccine that reduces acquisition of carriage and gives direct protection.
2026-06-01·AMERICAN JOURNAL OF PUBLIC HEALTH
Trends in Meningococcal B Vaccine Uptake Among 16- and 17-Year-Old Adolescents in the United States: An Analysis of the National Immunization Survey-Teen, 2018-2023.
Article
作者: Regmi, Neeta P ; Basta, Nicole E ; Ulrich, Angela K ; Xie, Tiankai
Objectives. To examine trends in meningococcal B (MenB) vaccination coverage among US adolescents aged 16 and 17 years. Methods. We conducted cross-sectional and longitudinal analyses of 2018 to 2023 National Immunization Survey-Teen data to calculate the annual percentage of eligible adolescents who received the MenB vaccine and to assess changes over time. Results. Only 19.8% of the 41 505 eligible adolescents initiated MenB vaccination between 2018 and 2023. A total of 24.5% (95% confidence interval [CI] = 22.5, 26.6) of adolescents received 1 or more MenB vaccinations in 2023, as compared with 13.2% (95% CI = 11.7, 14.6) in 2018. Among initiators, most received only 1 dose. Conclusions. MenB vaccination coverage among 16- and 17-year-old adolescents increased modestly between 2018 and 2023. As of 2023, approximately 3 out of 4 adolescents in this age group had not received the MenB vaccine. Public Health Implications. As of 2023, less than one quarter of 16- and 17-year-old adolescents had initiated MenB vaccination. Given that MenB has accounted for most meningococcal disease among adolescents and young adults since 2013, efforts to improve uptake are warranted. (Am J Public Health. 2026;116(6):851-854. https://doi.org/10.2105/AJPH.2026.308459).
2026-05-01·JOURNAL OF INFECTION
Neisseria meningitidis carriage, antimicrobial resistance, and risk factors in UK men who have sex with men
Article
作者: Kohli, Manik ; Suonpera, Emmi ; Gilson, Richard ; Harrison, Odile B ; Nur, Fowsiya ; Memon, Aminah ; Gharib, Yomna ; Liu, Wenyu ; Karathanasis, Christos
Urogenital infections caused by Neisseria meningitidis (Nm) are increasing globally, yet the prevalence, antimicrobial resistance profiles, and transmission dynamics of Nm in men who have sex with men (MSM) remain poorly defined. We conducted an oropharyngeal carriage study in 174 MSM attending a London sexual health clinic in 2023, prior to the implementation of 4CMenB vaccination and doxycycline post-exposure prophylaxis (doxyPEP). Nm was detected in 21.26% of participants, with carriage significantly associated with throat gonorrhoea, consistent with frequent co-colonisation. Whole-genome sequencing identified diverse lineages, including hyperinvasive clonal complexes (CC)11 and CC4821, and revealed widespread tetracycline resistance: 43% of isolates carried either a conjugative tet(M) plasmid or chromosomal tet(B) efflux locus. These findings indicate that MSM represent an important reservoir of tetracycline-resistant Nm, with the potential amplification of this phenotype following doxyPEP implementation, underscoring the need for genomic surveillance of Neisseria species in sexual networks.
144
项与 B群脑膜炎球菌疫苗(Novartis Pharma AG) 相关的新闻（医药）2026-06-03
Infectious Diseases and Therapy Volume 15, Issue 1
感染性疾病与治疗 15卷 1期
https://link.springer.com/journal/40121/volumes-and-issues/15-1
Review（综述）
1
How to Better Screen for Blood-Borne Viruses, Specifically HIV, in Hospital Emergency Departments: French and European Perspectives
医院急诊科如何更好地筛查血源性病毒（尤其是HIV）：法国和欧洲视角
Anthony Romain ChauvinBruno George SpireOlivier Bouchaud
Pages: 1 - 18
2
Understanding the Epidemiology and Contributing Factors of Post-COVID-19 Pertussis Outbreaks: A Narrative Review
了解新冠疫情后百日咳爆发的流行病学及影响因素：叙述性综述
Juan C. Vargas-ZambranoSorin AbrudanDenis Macina
Pages: 19 - 41
Part of 1 collection: Digital Features - Infectious Diseases
所属专题集：数字专题 - 传染病
3
The Structure, Properties, and Clinical Utility of Contezolid for Antituberculosis: A Narrative Review
康替唑胺抗结核的结构、特性及临床应用价值：叙述性综述
Tao ChenWeili LiFan Wu
Pages: 43 - 56
4
A Review of Doxycycline Post-Exposure Prophylaxis and Its Implications for Antimicrobial Resistance and the Human Microbiome
综述：多西环素暴露后预防用药及其对抗菌药物耐药性和人体微生物组的影响
Ruben Fernandez-IbanezSantiago MorenoMoises Fernandez
Pages: 57 - 84
Original Research（论著）
5
Clinical Impact of Implementing a Specific Clinical Pathway for the Management of Clostridioides difficile Infection
实施特定临床方法治疗艰难梭菌感染的临床影响
Miguel Rodríguez-FernándezRocio HerreroNicolás Merchante
Pages: 85 - 100
6
Intensive Care Unit Stay and Mechanical Ventilation Among Adults with Respiratory Syncytial Virus-Related Hospitalization by Age and Comorbidity Status
按年龄和合并症状况划分的呼吸道合胞病毒相关住院成人患者的重症监护病房住院时间和机械通气情况
Caihua LiangYun ZhouElizabeth Begier
Pages: 101 - 115
7
Treatment Persistence and Switch Among Medicare-Insured People with HIV and Gaps in Care
医疗保险覆盖的HIV感染者治疗坚持情况、用药转换情况及护理缺口
Suying LiUche MordiPhyllis C. Tien
Pages: 117 - 132
8
High-Dose Minocycline Improves Outcomes in Acinetobacter baumannii Group Pneumonia: A Propensity-Weighted Cohort Study with MIC-Based Insights for Breakpoint Revision
大剂量米诺环素可改善鲍曼不动杆菌群肺炎的预后：一项基于倾向加权队列的研究，并基于最低抑菌浓度提出折点修订见解
Yu-Tao TsengYang-Chuan ChenYung-Chih Wang
Pages: 133 - 148
9
Post-cranial Neurosurgery Cutibacterium acnes Infections: Clinical Correlates, Presentation, and Outcomes—A Matched Case–Case–Control Study
颅脑神经外科术后皮肤杆菌属感染：临床相关性、表现及预后——一项匹配病例-病例-对照研究
Neta ShirinOfek ArvivIli Margalit
Pages: 149 - 164
10
Bone Mineral Density Changes in People with HIV Who had Immediate Switch Versus Deferred Switch from Tenofovir Disoproxil Fumarate-Based Regimens to Bictegravir/Emtricitabine/Tenofovir Alafenamide: A Multicenter, Open-Label, Randomized Clinical Trial
从基于富马酸替诺福韦二吡呋酯的方案立即转换与延迟转换为比克替拉韦/恩曲他滨/丙酚替诺福韦的HIV感染者骨密度变化：一项多中心、开放标签、随机临床试验
Yueming ShaoXinping YangJun Chen
Pages: 165 - 181
11
Microbiological, Clinical, and Pharmacokinetic/Pharmacodynamic Data to Support EUCAST Aztreonam–Avibactam Minimum Inhibitory Concentration Susceptibility Breakpoints Against Enterobacterales
支持欧洲抗微生物药物敏感性试验委员会（EUCAST）针对肠杆菌科细菌的氨曲南-阿维巴坦最低抑菌浓度敏感性折点的微生物学、临床及药代动力学/药效学数据
Susan R. RaberRujia XieJoseph W. Chow
Pages: 183 - 195
12
Epidemiology of Invasive Escherichia coli Disease in Adults Using Routine Healthcare Records from the United States, 2002–2022
利用美国常规医疗记录（2002-2022年）分析成人侵袭性大肠杆菌病的流行病学特征
Mark A. SchmidtMaxim BlumJeroen Geurtsen
Pages: 197 - 216
13
Quality of Life and Treatment Satisfaction in People with HIV Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide: Pooled Analysis from Observational Cohort Studies
转换为比克替拉韦/恩曲他滨/丙酚替诺福韦的HIV感染者生活质量及治疗满意度：观察性队列研究的汇总分析
Andrea AntinoriYoshiyuki YokomakuMarta Boffito
Pages: 217 - 244
14
Dual Transmission Dynamics of Carbapenem Resistance in Pediatric Oncology: Plasmid-Mediated and Clonal Spread of blaNDM-5 Enterobacterales
儿科肿瘤中碳青霉烯类耐药性的双重传播动态：blaNDM-5肠杆菌科的质粒介导与克隆传播
Deena JalalMaryam LotfiLobna Shalaby
Pages: 245 - 263
Part of 1 collection:Digital Features - Infectious Diseases
所属专题集：数字专题 - 传染病
15
Cost-Effectiveness Analysis of Aztreonam–Avibactam Compared with Colistin Plus Meropenem in Treating Metallo-Beta-Lactamase-Producing Enterobacterales Infections in Spain
氨曲南-阿维巴坦与黏菌素联合美罗培南治疗西班牙产金属β-内酰胺酶肠杆菌科感染的成本效果分析
Gerardo AguilarPatricia Ruiz-GarbajosaJulián Torre-Cisneros
Pages: 265 - 284
16
Synchronous anal HPV Infection in Patients with HPV-Related Gynaecological Diseases: A Prospective Study
人乳头瘤病毒（HPV）相关妇科疾病患者同步肛部HPV感染：一项前瞻性研究
Michał BrzezińskiMaciej Stukan
Pages: 285 - 295
17
Growth in Anaerobic Bottles is an Independent Predictor of Mortality in Pseudomonas aeruginosa Bloodstream Infections
厌氧瓶中生长是铜绿假单胞菌血流感染死亡的独立预测因素
Daniel N. MarcoLaura MorataAlex Soriano
Pages: 297 - 311
18
Acute and Long-Term Healthcare Utilization and Expenditures for Serious Bacterial Infections among Newborns in US Hospitals
美国医院新生儿严重细菌感染的急性和长期医疗资源利用及费用
Kristen N. NobleKatharina SchleyDerek Weycker
Pages: 313 - 325
19
Impact of Risk Stacking on COVID-19–Related Healthcare Utilization: A Real-World Retrospective Cohort Study
风险叠加对新冠相关医疗资源利用的影响：一项现实回顾性队列研究
Frank R. ErnstLeah McGrathAlejandro Cané
Pages: 327 - 343
20
Chest Computed Tomography Patterns Associated with Severity in Adults with Respiratory Syncytial Virus Infection: A Retrospective Cohort Study
成人呼吸道合胞病毒感染严重程度相关的胸部计算机断层扫描模式：一项回顾性队列研究
Marie Le GoffYoussef ZaarourNicolas de Prost
Pages: 345 - 363
Case Series（病例系列）
21
Management and Resolution of Hypersensitivity Pneumonitis-Related Events in Japanese Patients Treated with Amikacin Liposome Inhalation Suspension in the CONVERT and INS-312 Clinical Trials
在CONVERT和INS-312临床试验中，接受硫酸阿米卡星脂质体吸入混悬液治疗的日本患者发生过敏性肺炎相关事件的管理与解决
Yoshitaka YamazakiTaku NakagawaNaoki Hasegawa
Pages: 365 - 379
Letter（读者来信）
22
A Response to: Letter to the Editor Regarding “The Risk of Herpes Zoster in Patients with Depressive Disorders: A German Claims Database Analysis”
对《关于“抑郁障碍患者带状疱疹风险：一项德国索赔数据库分析”的来信》的回复
Pavo MarijicJulian WitteChristiane Hermann
Pages: 381 - 383
23
Letter to the Editor Regarding“The Risk of Herpes Zoster in Patients with Depressive Disorders: A German Claims Database Analysis”
致编辑的信：关于“抑郁障碍患者带状疱疹风险：一项德国索赔数据库分析”
Kuan-Fu LiaoShih-Wei Lai
Pages: 385 - 386
Correction（更正）
24
Correction: Budget Impact Analysis of Fecal Microbiota Spores, Live-brpk (Formerly SER-109) for Recurrent Clostridioides difficile Infection in the United States
更正：美国复发性艰难梭菌感染粪便微生物群孢子活菌brpk（原SER-109）的预算影响分析
Michele WilsonYoav GolanAlpesh N. Amin
Pages: 387 - 387
25
Correction: A Response to: Letter to the Editor Regarding “The Risk of Herpes Zoster in Patients with Depressive Disorders: A German Claims Database Analysis”
更正：对《关于“抑郁障碍患者带状疱疹风险：一项德国索赔数据库分析”的来信》的回复
Pavo MarijicJulian WitteChristiane Hermann
Pages: 389 – 389
Infectious Diseases and Therapy Volume 15, Issue 2
感染性疾病与治疗 15卷 2期
https://link.springer.com/journal/40121/volumes-and-issues/15-2
Review（综述）
1
HepatitisA to E in People with HIV: A Virus-Specific Review of Prevention and Treatment
HIV感染者中的甲型至戊型肝炎：针对不同病毒的预防和治疗综述
Kuan-Yin LinYi-Chia HuangChien-Ching Hung
Pages: 391 - 415
2
The Cefazolin Inoculum Effect: An Underappreciated Factor in MSSA Treatment Strategies
头孢唑林接种物效应：甲氧西林敏感金黄色葡萄球菌治疗策略中一个未被充分重视的因素
Prakhar SrivastavaElizabeth SingletonRazieh Kebriaei
Pages: 417 - 441
3
Meningococcal Disease in Older Adults: Challenges in Diagnosis and Management
老年人群中的脑膜炎球菌病：诊断与治疗的挑战
Muhamed-Kheir TahaCatherine Weil-OlivierSaber Yezli
Pages: 443 - 459
4
The Future of Antibiotics and Artificial Intelligence: Some Thoughts from Discovery to Bedside
抗生素与人工智能的未来：从发现到临床应用的一些思考
Daniele Roberto GiacobbeAlessandra Agnese GrossiCesar de la Fuente-Nunez
Pages: 461 - 475
Original Research（论著）
5
Estimating the Health and Economic Burden of Pneumococcal Diseases Attributable to PCV21 Versus PCV20 or PPSV23 Serotypes Among Adults in Norway
挪威成年人中PCV21与PCV20或PPSV23血清型所致肺炎球菌疾病的健康和经济负担估算
Zinan YiAthar Ali TajikKwame Owusu-Edusei
Pages: 477 - 490
6
Seven versus Fourteen Days of Antibiotics for Gram-Negative Bacteremia from a Urinary Tract Source: a Systematic Review and Meta-analysis
尿路感染来源的革兰阴性菌血症抗生素治疗7天与14天的系统综述和荟萃分析
Graciela LunaAndrea RodriguezMichael Sabina
Pages: 491 - 505
7
Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Causing Healthcare-Associated Bloodstream Infections in Brazil: Results from A Prospective Countrywide Multicenter Study
巴西医疗保健相关血流感染中耐甲氧西林金黄色葡萄球菌的分子流行病学：一项前瞻性全国多中心研究的结果
Laura C. AntochevisLetícia O. SudbrackAlexandre P. Zavascki
Pages: 507 - 525
8
Long-Term Antibody Persistence After Hepatitis A Vaccination in Healthy Toddlers: Insights from Modeling
健康幼儿接种甲型肝炎疫苗后长期抗体持久性：基于模型的见解
Carlos EspulHéctor Horacio CuelloLaurent Coudeville
Pages: 527 - 538
9
Prevalence of Respiratory Syncytial Virus in Adult Patients with Respiratory Illnesses in Low to Middle-Income Countries: A Systematic Review and Meta-Analyses
中低收入国家成人呼吸道疾病患者中呼吸道合胞病毒的流行率：一项系统综述和荟萃分析
Digant GuptaAmandeep KaurAdriana Guzman-Holst
Pages: 539 - 559
10
Novel Diagnostic Marker Interleukin-33 for Invasive Pulmonary Aspergillosis in Acute-on-Chronic Liver Failure: A Proof-of-Concept Prospective Study
慢加急性肝衰竭合并侵袭性肺曲霉病的新型诊断标志物白细胞介素-33：一项概念验证前瞻性研究
Lanyue HuangMeng ZhangQin Ning
Pages: 561 - 576
11
Testing the Feasibility of a Self-Help Intervention That Includes Lymphatic Drainage to Reduce Fatigue-Related Symptoms Among Patients with Long COVID in General Practice: Experiences from Our Randomized Controlled Trial (RCT)
在全科医疗中测试包含淋巴引流以减轻长期新冠患者疲劳相关症状的自助干预措施的可行性：我们的随机对照试验（RCT）经验
Lisa RisteRaymond PerrinAdrian Heald
Pages: 577 - 589
12
Comparative Diagnostic Performance of the 36-Minute STANDARD M10 Fast Assay for Molecular Diagnosis of SARS-CoV-2, InfluenzaA and B, and Respiratory Syncytial Virus in Near-Patient Settings
36分钟STANDARD M10快速检测法在床旁检测中对SARS-CoV-2、甲型和乙型流感病毒以及呼吸道合胞病毒的分子诊断性能比较
Alexander DomnichGiada GarzilloGiancarlo Icardi
Pages: 591 - 604
13
Clinical Phenotypes of Critically Ill Patients with COVID-19 Infected with Omicron: A Nationwide Prospective Cohort Study
感染奥密克戎的危重症COVID-19患者的临床表型：一项全国性前瞻性队列研究
Etienne AudureauPierre Baythe SEVARVIR investigators
Pages: 605 - 628
Brief Report（简报）
14
How do Recent Population-Level RSVpreF Vaccine-Impact Results from the United Kingdom Relate to Previously Reported Vaccine Effectiveness Results?
英国最近公布的RSVpreF疫苗在人群层面的影响结果与之前报告的疫苗有效性结果有何关联？
Negar AliabadiQing LiuElizabeth Begier
Pages: 629 - 637
Case Report（病例报告）
15
Continuous Infusion of Aztreonam–Avibactam After High Loading Dose for an Infection Caused by an OXA-48- and NDM-1-Co-producing ST147 Klebsiella pneumoniae
针对OXA-48和NDM-1共产生的ST147型肺炎克雷伯菌感染，采用高负荷剂量后持续输注氨曲南-阿维巴坦
Paul Laffont-LozesFanny VillaRomaric Larcher
Pages: 639 - 649
Infectious Diseases and Therapy Volume 15, Issue 3
感染性疾病与治疗 15卷3期
https://link.springer.com/journal/40121/volumes-and-issues/15-3
Commentary（述评）
1
Taxonomy of the Full Health and Societal Value of Maternal Vaccination to Prevent Infant Respiratory Syncytial Virus Disease
预防婴儿呼吸道合胞病毒疾病中孕妇接种疫苗的全面健康及社会价值的分类学研究
J. P. SevillaDaria BurnesDavid E. Bloom
Pages: 651 - 682
Original Research（论著）
2
Characteristics of Haemophilus influenzae Isolates Responsible for Invasive Infections in Poland in 2018–2023
2018-2023年波兰引起侵袭性感染的流感嗜血杆菌分离株的特征
Marlena KiedrowskaKinga BłaszczykAnna Skoczyńska
Pages: 683 - 700
3
Evaluating the Effectiveness of 2024–2025 Seasonal mRNA-1273 Vaccination Against COVID-19-Related Hospitalizations and Medically Attended COVID-19 Among Adults Aged ≥ 18 years in the United States: An Observational Matched Cohort Study
评估2024-2025年季节性mRNA-1273疫苗对美国≥18岁成年人预防与COVID-19相关住院和就医的效力：一项观察性匹配队列研究
Nevena VicicAlina BogdanovAmanda Wilson
Pages: 701 - 714
4
Elevated Plasma GDF-15 Levels Are Associated with Aging, Multimorbidity, and Tobacco Exposure in People with HIV
HIV感染者中血浆GDF-15水平升高与衰老、多种合并症及烟草暴露相关
Aida López LópezJacobo Alonso DomínguezCoRIS Cohort
Pages: 715 - 731
5
High Burden of Febrile Sub-microscopic Plasmodium Mixed Infections in Central India: A Cross-Sectional Study
印度中部无症状疟原虫混合感染伴发热疾病负担高：一项横断面研究
Nimita DeoraVeena PandeAbhinav Sinha
Pages: 733 - 747
6
How Status Quo Bias Shapes Willingness, Uptake, and Adherence to PrEP Among Chinese MSM: A Behavioral Economics Perspective
从行为经济学视角看现状偏见如何影响中国男男性行为者对暴露前预防的意愿、接受度和依从性
Min ZhaoXiang ZhaoLei Zhang
Pages: 749 - 767
7
Immunogenicity and Safety of Quadrivalent Meningococcal Conjugate Vaccine (MenACYW-TT) in Potential Hajj/Umrah Pilgrims Aged≥56 Years: A Phase III, Open-Label Study
四价脑膜炎球菌结合疫苗（MenACYW-TT）在≥56岁潜在朝觐/副朝觐者中的免疫原性和安全性：一项III期、开放标签研究
Ghassan S. DbaiboIsmail BalikMehmet Ceyhan
Pages: 769 - 785
Part of 1 collection: Digital Features - Infectious Diseases
所属合集：数字专题 -传染病
8
Clinical Impact of Droplet Digital PCR-Guided Antibiotic Stewardship on Prognosis in Patients with Suspected Bloodstream Infection: A Prospective Observational Study
液滴数字PCR指导的抗生素管理对患者疑似血流感染预后的临床影响：一项前瞻性观察研究
Ziqiang ShaoJingwen ZhuBangchuan Hu
Pages: 787 - 807
9
Outpatient RSV Testing Rates Among US Adults with Lower Respiratory Tract Disease, 2017–2024
2017-2024年美国下呼吸道疾病成人患者门诊呼吸道合胞病毒检测率
Katherine K. PerezKashmira DateElizabeth Begier
Pages: 809 - 834
10
Role of Cefiderocol in the Treatment of Carbapenem-Resistant Nonfermenting Gram-Negative Bacilli (Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia) Infections: An Expert Statement
头孢地尔在治疗碳青霉烯类耐药非发酵革兰氏阴性杆菌（鲍曼不动杆菌、铜绿假单胞菌和嗜麦芽窄食单胞菌）感染中的作用：专家声明
Alexandre BleibtreuYoussef BennisCoRIS Cohort
Pages: 835 - 857
11
IgG4 Neutralization and Sustained Total IgG Fc-Effector Functions Following Repeated SARS-CoV-2 Vaccination with mRNA-1273
重复接种mRNA-1273疫苗后IgG4中和作用及总IgG Fc效应功能的持续存在
Paulina KaplonekHarry BerteraCarole Henry
Pages: 859 - 874
12
Rising Burden of Herpes Zoster among General Adults and Increased-Risk Groups in Eastern China, 2015–2021: A Population-Based Cohort Study
2015-2021年中国东部普通成人及高风险人群带状疱疹负担上升：一项基于人群的队列研究
Zhenwei LiShenjia GuChuanxi Fu
Pages: 875 - 888
13
Safety and Efficacy of Fecal Microbiota, Live-jslm for Prevention of Recurrent Clostridioides difficile Infection Among Hospitalized Participants in PUNCH CD3-OLS
PUNCH CD3-OLS研究中住院患者使用活菌粪便微生物群（Live-jslm）预防复发性艰难梭菌感染的安全性和有效性
Andrew M. SkinnerThomas P. LodiseJordan E. Axelrad
Pages: 889 - 901
Letter（读者来信）
14
Letter to the Editor Regarding “Advanced Liver Disease Events in People with HIV and Hepatitis B Virus Coinfection Initiating Antiretroviral Therapy in the United States”
致编辑的信：关于“美国HIV和乙型肝炎病毒合并感染者启动抗逆转录病毒治疗后发生晚期肝病事件”
Keiji Konishi
Pages: 903 - 905
15
A Response to: Letter to the Editor Regarding “Advanced Liver Disease Events in People with HIV and Hepatitis B Virus Coinfection Initiating Antiretroviral Therapy in the United States”
回复：致编辑的信——关于“美国HIV和乙型肝炎病毒合并感染者启动抗逆转录病毒治疗后发生晚期肝病事件”
Ching-Yi ChuoWoodie ZachryLi Tao
Pages: 907 - 909
16
A Response to: “Letter to the Editor regarding ‘Impact of Continuous Renal Replacement Therapy with Polyacrylonitrile-Derived Filter on Caspofungin Concentration: A Retrospective Study'”
回复：致编辑的信——关于“聚丙烯腈衍生滤器连续性肾脏替代治疗对卡泊芬净浓度的影响：一项回顾性研究”
Romain ArrestierKeyvan Razazi
Pages: 911 - 914
17
Letter to the Editor regarding 'Impact of Continuous Renal Replacement Therapy with Polyacrylonitrile-Derived Filter on Caspofungin Concentration: A Retrospective Study'
致编辑的信——关于“聚丙烯腈衍生滤器连续性肾脏替代治疗对卡泊芬净浓度的影响：一项回顾性研究”
Julien MassolValentin MauletFrédéric J. Baud
Pages: 915 - 919
Infectious Diseases and Therapy Volume 15, Issue 4
感染性疾病与治疗 15卷 4期
https://link.springer.com/journal/40121/volumes-and-issues/15-4
Review（综述）
1
Outpatient Parenteral Antimicrobial Therapy (OPAT) in Italy: A Scoping Review
意大利门诊静脉注射抗菌药物治疗（OPAT）：一项范围综述
Chiara MorealSimone GiulianoCarlo Tascini
Pages: 921 - 939
2
Reimagining Phage Therapy for MDR Pathogens: From Biobanks to Health System Integration—A Review
重新构想噬菌体疗法治疗多重耐药病原体：从生物银行到卫生系统整合——综述
Abay A. AyeleWenfeng LiuAbel A. Negash
Pages: 941 - 957
3
Navigating the Viral Hepatitis Drug Landscape: New Discoveries and Enduring Challenges. A Narrative Review
探索病毒性肝炎药物领域：新发现与持久挑战。一篇叙述性综述
He-ming SunXing-yu WangYan-hang Gao
Pages: 959 - 985
Original Research（论著）
4
Predictive Utility of the Pediatric-EQUAL Scale in Pediatric Candidemia Admitted to PICU Association with Clinical and Microbiological Factors Related Mortality
儿科-EQUAL量表对入住PICU的念珠菌血症患儿的预测效用：与临床和微生物学因素相关死亡率的关联
Muhterem DuyuAyşe Aşık
Pages: 987 - 1001
Publisher Correction（出版商更正）
5
Publisher Correction: Predictive Utility of the Pediatric-EQUAL Scale in Pediatric Candidemia Admitted to PICU Association with Clinical and Microbiological Factors Related Mortality
出版商更正：儿科-EQUAL量表对入住PICU的念珠菌血症患儿的预测效用：与临床和微生物学因素相关死亡率的关联
Muhterem DuyuAyşe Aşık
Pages: 1003 - 1005
Original Research（论著）
6
A Statistical Immune Correlates of Protection Model for Predicting Efficacy from Neutralizing Antibody Titers to Establish Immunobridging of Monoclonal Antibodies for Prevention of COVID-19
用于从中和抗体滴度预测疗效以建立预防新冠肺炎单克隆抗体免疫桥接的统计免疫保护相关因素模型
Ilker YalcinLeijun HuMark A. Wingertzahn
Pages: 1007 - 1017
7
Early Antibiotic Therapy in Sepsis Without Shock: A Multimethod Study of Heterogeneous Treatment Effects in ICU Patients
无休克性脓毒症的早期抗生素治疗：一项针对ICU患者异质性治疗效果的多方法研究
Peng ZhangTongkun ZuoYing Huang
Pages: 1019 - 1033
8
Post-marketing Safety Surveillance of 23-Valent Pneumococcal Polysaccharide Vaccine Administered Alone and Concomitantly with Influenza Vaccine in Individuals Aged 2Years and Older in China
中国2岁及以上人群单独接种及与流感疫苗同时接种23价肺炎球菌多糖疫苗的上市后安全监测
Yun-feng ShiLin-hang JuHong-xing Pan
Pages: 1035 - 1046
9
Cost-Effectiveness of Nirsevimab and Clesrovimab in Preventing Respiratory Syncytial Virus Lower Respiratory Tract Disease in Infants in the United States: A Modeling Study
美国预防婴儿呼吸道合胞病毒下呼吸道感染：Nirsevimab和Clesrovimab的成本效益——一项建模研究
Benjamin YarnoffMatthieu BeuveletLeonard R. Krilov
Pages: 1047 - 1073
10
Oritavancin in Complicated Bloodstream Infections and Endocarditis in Spain and Italy (ORIBAC Study): A Retrospective Multicenter Observational Study
西班牙和意大利奥利他万星治疗复杂血流感染和心内膜炎（ORIBAC研究）：一项回顾性多中心观察研究
Antonio VenaLaura MezzogoriORIBAC study group
Pages: 1075 - 1092
11
Mitigating Vaccine Disparities Through Faith-Based Intervention: A Pre-Post Analysis of Recombinant Zoster Vaccine Knowledge and Acceptance in Socially Vulnerable Racial and Ethnic Minoritized Communities
通过基于信仰的干预措施减轻疫苗差异：对社会弱势的种族和少数民族群体重组带状疱疹疫苗认知和接受度的前后分析
Jacinda C. Abdul-MutakabbirRaheem Abdul-MutakabbirSamuel J. Casey
Pages: 1093 - 1114
12
Epidemiological Burden and Hospitalization Trends of Human Metapneumovirus in Spain (2016–2023): A Retrospective Study
西班牙人类偏肺病毒的流行病学负担和住院趋势（2016 - 2023年）：一项回顾性研究
Oscar Brochado-KithRuth Gil-PrietoAngel Gil-de-Miguel
Pages: 1115 - 1135
13
Using Real-World Data to Support Claim Expansion of the Cobas SARS-CoV-2 Test in Asymptomatic Testing: Data from the National Football League Occupational Surveillance Program
使用现实数据支持Cobas SARS-CoV-2检测在无症状检测中的适用范围扩大：来自美国国家橄榄球联盟职业监测计划的数据
Baiyu YangErin B. WassermanElodie Baumfeld Andre
Pages: 1137 - 1148
Infectious Diseases and Therapy Volume 15, Issue 5
感染性疾病与治疗 15卷 5期
https://link.springer.com/journal/40121/volumes-and-issues/15-5
Review（综述）
1
Efficacy and Safety of Tetracyclines in Bone and Joint Infections: A Literature Review
四环素类药物治疗骨关节感染的有效性和安全性：文献综述
Paul Laffont-LozesRomaric LarcherAlbert Sotto
Pages: 1149 - 1174
2
The Ongoing Challenge of Pertussis in Eastern and Northern Europe: Recommendations from the Global Pertussis Initiative
东欧和北欧百日咳持续存在的挑战：全球百日咳倡议的建议
Mine Durusu TanrioverUlrich HeiningerKevin Forsyth
Pages: 1175 - 1201
3
Antibiotic Pharmacokinetics and Prostate Penetration in Bacterial Prostatitis: A Systematic Review
细菌性前列腺炎的抗生素药代动力学及前列腺穿透性：系统综述
Rui GeXinwen NianZhuo Wang
Pages: 1203 - 1248
4
Treatment for Dientamoeba fragilis: A Systematic Review and Meta-analysis
脆弱双核阿米巴病的治疗：系统综述和荟萃分析
Nadav BaharavMichael ItzkovichDafna Yahav
Pages: 1249 - 1262
Original Research（论著）
5
Preparing for Tuberculosis Vaccine M72/AS01E Implementation: A Global Demand Forecast and Key Influential Factors
结核病疫苗M72/AS01E实施准备工作：全球需求预测及关键影响因素
Judith KallenbergDominique MileaAgathe Philippot
Pages: 1263 - 1279
Correction（更正）
6
Correction: Preparing for Tuberculosis Vaccine M72/AS01E Implementation: A Global Demand Forecast and Key Influential Factors
更正：结核病疫苗M72/AS01E实施准备工作：全球需求预测及关键影响因素
Judith KallenbergDominique MileaAgathe Philippot
Pages: 1281 - 1281
Original Research（论著）
7
Impact of Nirsevimab on Pediatric RSV-Related Lower Respiratory Tract Infections: A Retrospective Pre–Post Observational Study in Tuscany, Italy
尼塞韦单抗对意大利托斯卡纳地区儿童呼吸道合胞病毒相关下呼吸道感染的影响：一项回顾性前后对照观察研究
Francesco NiedduMarta VerzieriMaria Moriondo
Pages: 1283 - 1295
8
Antiretroviral Therapy Switching Among People with HIV in the United States is not Uncommon Despite Virologic Suppression: An OPERA Cohort Study
尽管病毒学抑制，美国HIV感染者更换抗逆转录病毒疗法的情况并不少见：OPERA队列研究
Karam MounzerMichael D. OstermanGregory P. Fusco
Pages: 1297 - 1314
9
Role of Community Associations in HIV, HBV and HCV Screening and Support for Migrant Populations in France: Results of the DéPAC Study
社区协会在法国移民人群HIV、HBV和HCV筛查及支持中的作用：DéPAC研究结果
Dulce AlfaiateJean-Claude TardyFrançois Durand
Pages: 1315 - 1333
Part of 1 collection:Digital Features - Infectious Diseases
所属专题合集：数字专题-传染病
10
Impact of Risk Factor Combinations on Severe COVID-19 Outcomes Among Outpatients
风险因素联合作用对门诊患者严重新冠肺炎预后的影响
Haley J. AppanealVrishali V. LopesAisling R. Caffrey
Pages: 1335 - 1351
11
Clinical Outcomes Among Older Adults Hospitalized with Respiratory Syncytial Virus and Influenza Infection: A Retrospective Analysis
老年住院患者呼吸道合胞病毒和流感病毒感染的临床预后：一项回顾性分析
Menucha JurkowiczIli MargalitMichal Mandelboim
Pages: 1353 - 1367
12
The Impact and Effectiveness of a Two-Dose Varicella Immunization Program Among School Children: Evidence from Quasi-experimental Analyses
两剂水痘免疫接种计划对学龄儿童的影响和有效性：来自准实验分析的证据
Huiqiao GuXu XieYawen Jiang
Pages: 1369 - 1384
13
Lessons Learned: Defining the Right Specifications for Diagnostics in Outbreak Situations
经验教训：疫情情况下确定诊断的正确规范
Markus BeutlerPablo BonvehíAndreas Wieser
Pages: 1385 - 1399
14
Post-COVID-19 Burden of Severe Influenza in England Among Overall Population and High-Risk Groups: Results From the INFORM Study, 2022–2023
2022-2023年INFORM研究结果：英格兰地区普通人群和高危人群中新冠肺炎后严重流感的负担
Wilhelmine MeerausLucy CartyLance Turtle
Pages: 1401 - 1424
15
Respiratory Syncytial Virus Immunization Strategies for Older Adults in Gulf Cooperation Council Countries: Expert Consensus and Recommendations
海湾合作委员会国家老年人呼吸道合胞病毒免疫接种策略：专家共识和建议
Nawal AlKaabiMohammed AbukhattabSalah Al Awaidy
Pages: 1425 - 1449
16
Prospective Study of Treatment with Ensitrelvir for COVID-19 in Patients Undergoing Hemodialysis (PROTECT-HD)
血液透析患者使用恩赛特韦治疗新冠肺炎的前瞻性研究（PROTECT-HD）
Mineaki KitamuraTakahiro TakazonoHiroshi Mukae
Pages: 1451 - 1466
17
Diagnostic Performance and Clinical Outcomes of Pertussis in Hospitalized Children in Relation to Available Vaccination Status: A Retrospective Cohort Study
在现有疫苗接种情况下，住院患儿百日咳的诊断性能和临床预后：一项回顾性队列研究
Dominika LachowiczBarbara JastrzębskaEdyta Podsiadły
Pages: 1467 - 1477
18
Demonstrating Clinical Performance of the Elecsys Anti-SARS-CoV-2 Anti-Nucleocapsid Immunoassay Using Real-World Data to Support Regulatory Decision-Making in the USA
使用现实数据证明Elecsys抗SARS-CoV-2抗核衣壳免疫检测的临床性能，以支持美国监管决策
Eldad A. HodBaiyu YangElodie Baumfeld Andre
Pages: 1479 - 1491
19
Efficacy and Safety of Glecaprevir/Pibrentasvir in Participants with Chronic HCV Infection and Comorbidities or Multiple Concomitant Medications: An Integrated Analysis
格卡瑞韦/哌仑他韦治疗慢性丙型肝炎病毒感染且伴有合并症或多种合并用药受试者的有效性和安全性：一项综合分析
Curtis CooperShweta A. RainaStanislas Pol
Pages: 1493 - 1508
20
Modeling the Public Health Impact of Introducing 4CMenB Vaccination for Infants in the Brazilian National Immunization Program
在巴西国家免疫计划中引入4CMenB疫苗对公共卫生的影响建模
Thatiana PintoZeki KocaataElise Kuylen
Pages: 1509 - 1524
21
Multicenter Real-World Outpatient Use of Intravenous Omadacycline
门诊使用静脉注射奥马环素的多中心现实情况
Lucinda J. Van AnglenCathy L. KooKimberly A. Couch
Pages: 1525 - 1538
22
Burden of Respiratory Syncytial Virus in Older ADults in Nagasaki, Japan (Nagasaki ROAD): Preliminary Results (April 2024–March 2025) of a Prospective, Multicenter, Epidemiological Study
日本长崎地区老年人呼吸道合胞病毒负担（长崎ROAD）：一项前瞻性、多中心、流行病学研究的初步结果（2024年4月-2025年3月）
Takahiro TakazonoNorihito KakuHiroshi Mukae
Pages: 1539 - 1564
Brief Report（简报）
23
Effectiveness of Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide from Rilpivirine or Other Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI)-Based Antiretroviral Therapy in Virologically Suppressed People with HIV: A Retrospective Analysis (DRIVE-SWITCH Study)
对于病毒学抑制的HIV感染者，从利匹韦林或其他非核苷类逆转录酶抑制剂（NNRTI）为基础的抗逆转录病毒疗法转换为比克替拉韦/恩曲他滨/丙酚替诺福韦的有效性：一项回顾性分析（DRIVE-SWITCH研究）
Roberta GagliardiniAlessandro CaioliAndrea Antinori
Pages: 1565 - 1575
Infectious Diseases and Therapy Volume 15, Issue 6
感染性疾病与治疗 15卷 6期
https://link.springer.com/journal/40121/volumes-and-issues/15-6
Commentary（述评）
1
Adult RSV Vaccination: What Is the Role of RSV Subgroup in Disease Prevention?
成人RSV疫苗接种：RSV亚群在疾病预防中的作用是什么？
S. Elizabeth WilliamsGiovanni Checcucci LisiElizabeth Begier
Pages: 1577 - 1587
Review（综述）
2
Epidemiology of Acute Cystitis or Afebrile Urinary Tract Infection in Adult Men: A Systematic Literature Review
成年男性急性膀胱炎或无热尿路感染的流行病学：一项系统文献综述
Mary E. GeorgiouPriscilla WittkopfFanny S. Mitrani-Gold
Pages: 1589 - 1606
3
Non-intravenous Amphotericin B: A Review of Localized Administration Routes
非静脉注射两性霉素B：局部给药途径综述
Francelise Bridi CavassinLaura Fernanda RodriguesMarcello Mihailenko Chaves Magri
Pages: 1607 - 1632
4
Infections Caused by Fusobacterium Species: Microbiology, Clinical Syndromes and Management: A Narrative Review
Fusobacterium属引起的感染：微生物学、临床综合征及治疗：一篇叙述性综述
Michal ParetGuy KatzenellenbogenDafna Yahav
Pages: 1633 - 1647
5
When Culture Results Don’t Tell the Whole Story: A Practical Review of Antibiotics Pitfalls for Clinical Decision-Making
当培养结果不能说明全部问题：临床决策中抗生素陷阱的实用综述
Ahmed M. ShomanAyman A. Radwan
Pages: 1649 - 1667
Original Research（论著）
6
Cost-Effectiveness of Alternative Immunization Strategies to Protect Infants Against Respiratory Syncytial Virus in Germany: A Decision Modeling Study
德国保护婴儿免受呼吸道合胞病毒感染的替代免疫策略的成本效益：一项决策模型研究
Caroline LadeErin QuinnAhuva Averin
Pages: 1669 - 1687
7
Estimation of Costs Related to the Management of Herpes Zoster and its Complications in Vietnam: A Medical Chart Review
越南带状疱疹及其并发症治疗相关费用估算：一项病历回顾研究
Nurilign AhmedVan M. NguyenHuong T. T. Nguyen
Pages: 1689 - 1704
8
Validation of the VIRSTA and VIRSTA+ Scores to Identify Patients with Staphylococcus aureus Bacteremia at Very Low Risk of Infective Endocarditis
VIRSTA和VIRSTA+评分验证以识别感染性心内膜炎极低风险的金黄色葡萄球菌菌血症患者
Daniela Malano-BarlettaMiguel Ángel VerdejoAlex Soriano
Pages: 1705 - 1718
9
The Shifting Landscape of HIV–Tuberculosis Co-Infection in the MENA Region with a Focus on Saudi Arabia: A Systematic Epidemiological Analysis over Three Decades
MENA地区HIV–结核共感染的变化格局：以沙特阿拉伯为重点的三十年系统流行病学分析
Zikria SaleemMasaad Saeed AlmutairiFaris S. Alnezary
Pages: 1719 - 1731
10
Comprehensive Analysis of Health Service Utilization for Febrile Illness and Malaria in Malaria-Endemic States in India: LLINs as a Pillar of Control Strategies
印度疟疾流行邦发热疾病和疟疾卫生服务利用的综合分析：长效杀虫蚊帐作为控制策略的支柱
Vani H. ChalageriShrinivasa B. MarinaikAnupkumar R. Anvikar
Pages: 1733 - 1746
11
Observational, Post-marketing Surveillance of Safety and Effectiveness of Glecaprevir/Pibrentasvir in Korean Patients with Chronic Hepatitis C
格卡瑞韦/匹布他韦在韩国慢性丙型肝炎患者中的观察性上市后安全性和有效性监测
Jin-Woo LeeSang Hoon AhnJeong Heo
Pages: 1747 - 1761
12
Post-Marketing Active Surveillance of Adverse Events Following Quadrivalent Subunit Influenza Vaccine in Healthy Participants Aged≥3 Years in China
中国≥3岁健康人群接种四价亚单位流感疫苗后不良事件的上市后主动监测
Mingwei WeiYu PanHongxing Pan
Pages: 1763 - 1778
Systematic Review（系统综述）
13
Point-of-Care Nucleic Acid Amplification Tests for Respiratory Syncytial Virus Detection in Children and Adults: A Systematic Literature Review
用于儿童和成人呼吸道合胞病毒检测的即时核酸扩增检测：一项系统文献综述
Kashmira DateKyle FowlerElizabeth Begier
Pages: 1779 - 1799
Correction（勘误）
14
Correction: The Cefazolin Inoculum Effect: An Underappreciated Factor in MSSA Treatment Strategies
勘误：头孢唑林接种效应：MSSA治疗策略中被低估的因素
Prakhar SrivastavaElizabeth SingletonRazieh Kebriaei
Pages: 1801 – 1801
2026-05-31
Infectious Diseases and Therapy Volume 15, Issue 1
感染性疾病与治疗 15卷 1期
https://link.springer.com/journal/40121/volumes-and-issues/15-1
Review（综述）
1
How to Better Screen for Blood-Borne Viruses, Specifically HIV, in Hospital Emergency Departments: French and European Perspectives
医院急诊科如何更好地筛查血源性病毒（尤其是HIV）：法国和欧洲视角
Anthony Romain ChauvinBruno George SpireOlivier Bouchaud
Pages: 1 - 18
2
Understanding the Epidemiology and Contributing Factors of Post-COVID-19 Pertussis Outbreaks: A Narrative Review
了解新冠疫情后百日咳爆发的流行病学及影响因素：叙述性综述
Juan C. Vargas-ZambranoSorin AbrudanDenis Macina
Pages: 19 - 41
Part of 1 collection: Digital Features - Infectious Diseases
所属专题集：数字专题 - 传染病
3
The Structure, Properties, and Clinical Utility of Contezolid for Antituberculosis: A Narrative Review
康替唑胺抗结核的结构、特性及临床应用价值：叙述性综述
Tao ChenWeili LiFan Wu
Pages: 43 - 56
4
A Review of Doxycycline Post-Exposure Prophylaxis and Its Implications for Antimicrobial Resistance and the Human Microbiome
综述：多西环素暴露后预防用药及其对抗菌药物耐药性和人体微生物组的影响
Ruben Fernandez-IbanezSantiago MorenoMoises Fernandez
Pages: 57 - 84
Original Research（论著）
5
Clinical Impact of Implementing a Specific Clinical Pathway for the Management of Clostridioides difficile Infection
实施特定临床方法治疗艰难梭菌感染的临床影响
Miguel Rodríguez-FernándezRocio HerreroNicolás Merchante
Pages: 85 - 100
6
Intensive Care Unit Stay and Mechanical Ventilation Among Adults with Respiratory Syncytial Virus-Related Hospitalization by Age and Comorbidity Status
按年龄和合并症状况划分的呼吸道合胞病毒相关住院成人患者的重症监护病房住院时间和机械通气情况
Caihua LiangYun ZhouElizabeth Begier
Pages: 101 - 115
7
Treatment Persistence and Switch Among Medicare-Insured People with HIV and Gaps in Care
医疗保险覆盖的HIV感染者治疗坚持情况、用药转换情况及护理缺口
Suying LiUche MordiPhyllis C. Tien
Pages: 117 - 132
8
High-Dose Minocycline Improves Outcomes in Acinetobacter baumannii Group Pneumonia: A Propensity-Weighted Cohort Study with MIC-Based Insights for Breakpoint Revision
大剂量米诺环素可改善鲍曼不动杆菌群肺炎的预后：一项基于倾向加权队列的研究，并基于最低抑菌浓度提出折点修订见解
Yu-Tao TsengYang-Chuan ChenYung-Chih Wang
Pages: 133 - 148
9
Post-cranial Neurosurgery Cutibacterium acnes Infections: Clinical Correlates, Presentation, and Outcomes—A Matched Case–Case–Control Study
颅脑神经外科术后皮肤杆菌属感染：临床相关性、表现及预后——一项匹配病例-病例-对照研究
Neta ShirinOfek ArvivIli Margalit
Pages: 149 - 164
10
Bone Mineral Density Changes in People with HIV Who had Immediate Switch Versus Deferred Switch from Tenofovir Disoproxil Fumarate-Based Regimens to Bictegravir/Emtricitabine/Tenofovir Alafenamide: A Multicenter, Open-Label, Randomized Clinical Trial
从基于富马酸替诺福韦二吡呋酯的方案立即转换与延迟转换为比克替拉韦/恩曲他滨/丙酚替诺福韦的HIV感染者骨密度变化：一项多中心、开放标签、随机临床试验
Yueming ShaoXinping YangJun Chen
Pages: 165 - 181
11
Microbiological, Clinical, and Pharmacokinetic/Pharmacodynamic Data to Support EUCAST Aztreonam–Avibactam Minimum Inhibitory Concentration Susceptibility Breakpoints Against Enterobacterales
支持欧洲抗微生物药物敏感性试验委员会（EUCAST）针对肠杆菌科细菌的氨曲南-阿维巴坦最低抑菌浓度敏感性折点的微生物学、临床及药代动力学/药效学数据
Susan R. RaberRujia XieJoseph W. Chow
Pages: 183 - 195
12
Epidemiology of Invasive Escherichia coli Disease in Adults Using Routine Healthcare Records from the United States, 2002–2022
利用美国常规医疗记录（2002-2022年）分析成人侵袭性大肠杆菌病的流行病学特征
Mark A. SchmidtMaxim BlumJeroen Geurtsen
Pages: 197 - 216
13
Quality of Life and Treatment Satisfaction in People with HIV Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide: Pooled Analysis from Observational Cohort Studies
转换为比克替拉韦/恩曲他滨/丙酚替诺福韦的HIV感染者生活质量及治疗满意度：观察性队列研究的汇总分析
Andrea AntinoriYoshiyuki YokomakuMarta Boffito
Pages: 217 - 244
14
Dual Transmission Dynamics of Carbapenem Resistance in Pediatric Oncology: Plasmid-Mediated and Clonal Spread of blaNDM-5 Enterobacterales
儿科肿瘤中碳青霉烯类耐药性的双重传播动态：blaNDM-5肠杆菌科的质粒介导与克隆传播
Deena JalalMaryam LotfiLobna Shalaby
Pages: 245 - 263
Part of 1 collection:Digital Features - Infectious Diseases
所属专题集：数字专题 - 传染病
15
Cost-Effectiveness Analysis of Aztreonam–Avibactam Compared with Colistin Plus Meropenem in Treating Metallo-Beta-Lactamase-Producing Enterobacterales Infections in Spain
氨曲南-阿维巴坦与黏菌素联合美罗培南治疗西班牙产金属β-内酰胺酶肠杆菌科感染的成本效果分析
Gerardo AguilarPatricia Ruiz-GarbajosaJulián Torre-Cisneros
Pages: 265 - 284
16
Synchronous anal HPV Infection in Patients with HPV-Related Gynaecological Diseases: A Prospective Study
人乳头瘤病毒（HPV）相关妇科疾病患者同步肛部HPV感染：一项前瞻性研究
Michał BrzezińskiMaciej Stukan
Pages: 285 - 295
17
Growth in Anaerobic Bottles is an Independent Predictor of Mortality in Pseudomonas aeruginosa Bloodstream Infections
厌氧瓶中生长是铜绿假单胞菌血流感染死亡的独立预测因素
Daniel N. MarcoLaura MorataAlex Soriano
Pages: 297 - 311
18
Acute and Long-Term Healthcare Utilization and Expenditures for Serious Bacterial Infections among Newborns in US Hospitals
美国医院新生儿严重细菌感染的急性和长期医疗资源利用及费用
Kristen N. NobleKatharina SchleyDerek Weycker
Pages: 313 - 325
19
Impact of Risk Stacking on COVID-19–Related Healthcare Utilization: A Real-World Retrospective Cohort Study
风险叠加对新冠相关医疗资源利用的影响：一项现实回顾性队列研究
Frank R. ErnstLeah McGrathAlejandro Cané
Pages: 327 - 343
20
Chest Computed Tomography Patterns Associated with Severity in Adults with Respiratory Syncytial Virus Infection: A Retrospective Cohort Study
成人呼吸道合胞病毒感染严重程度相关的胸部计算机断层扫描模式：一项回顾性队列研究
Marie Le GoffYoussef ZaarourNicolas de Prost
Pages: 345 - 363
Case Series（病例系列）
21
Management and Resolution of Hypersensitivity Pneumonitis-Related Events in Japanese Patients Treated with Amikacin Liposome Inhalation Suspension in the CONVERT and INS-312 Clinical Trials
在CONVERT和INS-312临床试验中，接受硫酸阿米卡星脂质体吸入混悬液治疗的日本患者发生过敏性肺炎相关事件的管理与解决
Yoshitaka YamazakiTaku NakagawaNaoki Hasegawa
Pages: 365 - 379
Letter（读者来信）
22
A Response to: Letter to the Editor Regarding “The Risk of Herpes Zoster in Patients with Depressive Disorders: A German Claims Database Analysis”
对《关于“抑郁障碍患者带状疱疹风险：一项德国索赔数据库分析”的来信》的回复
Pavo MarijicJulian WitteChristiane Hermann
Pages: 381 - 383
23
Letter to the Editor Regarding“The Risk of Herpes Zoster in Patients with Depressive Disorders: A German Claims Database Analysis”
致编辑的信：关于“抑郁障碍患者带状疱疹风险：一项德国索赔数据库分析”
Kuan-Fu LiaoShih-Wei Lai
Pages: 385 - 386
Correction（更正）
24
Correction: Budget Impact Analysis of Fecal Microbiota Spores, Live-brpk (Formerly SER-109) for Recurrent Clostridioides difficile Infection in the United States
更正：美国复发性艰难梭菌感染粪便微生物群孢子活菌brpk（原SER-109）的预算影响分析
Michele WilsonYoav GolanAlpesh N. Amin
Pages: 387 - 387
25
Correction: A Response to: Letter to the Editor Regarding “The Risk of Herpes Zoster in Patients with Depressive Disorders: A German Claims Database Analysis”
更正：对《关于“抑郁障碍患者带状疱疹风险：一项德国索赔数据库分析”的来信》的回复
Pavo MarijicJulian WitteChristiane Hermann
Pages: 389 – 389
Infectious Diseases and Therapy Volume 15, Issue 2
感染性疾病与治疗 15卷 2期
https://link.springer.com/journal/40121/volumes-and-issues/15-2
Review（综述）
1
HepatitisA to E in People with HIV: A Virus-Specific Review of Prevention and Treatment
HIV感染者中的甲型至戊型肝炎：针对不同病毒的预防和治疗综述
Kuan-Yin LinYi-Chia HuangChien-Ching Hung
Pages: 391 - 415
2
The Cefazolin Inoculum Effect: An Underappreciated Factor in MSSA Treatment Strategies
头孢唑林接种物效应：甲氧西林敏感金黄色葡萄球菌治疗策略中一个未被充分重视的因素
Prakhar SrivastavaElizabeth SingletonRazieh Kebriaei
Pages: 417 - 441
3
Meningococcal Disease in Older Adults: Challenges in Diagnosis and Management
老年人群中的脑膜炎球菌病：诊断与治疗的挑战
Muhamed-Kheir TahaCatherine Weil-OlivierSaber Yezli
Pages: 443 - 459
4
The Future of Antibiotics and Artificial Intelligence: Some Thoughts from Discovery to Bedside
抗生素与人工智能的未来：从发现到临床应用的一些思考
Daniele Roberto GiacobbeAlessandra Agnese GrossiCesar de la Fuente-Nunez
Pages: 461 - 475
Original Research（论著）
5
Estimating the Health and Economic Burden of Pneumococcal Diseases Attributable to PCV21 Versus PCV20 or PPSV23 Serotypes Among Adults in Norway
挪威成年人中PCV21与PCV20或PPSV23血清型所致肺炎球菌疾病的健康和经济负担估算
Zinan YiAthar Ali TajikKwame Owusu-Edusei
Pages: 477 - 490
6
Seven versus Fourteen Days of Antibiotics for Gram-Negative Bacteremia from a Urinary Tract Source: a Systematic Review and Meta-analysis
尿路感染来源的革兰阴性菌血症抗生素治疗7天与14天的系统综述和荟萃分析
Graciela LunaAndrea RodriguezMichael Sabina
Pages: 491 - 505
7
Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Causing Healthcare-Associated Bloodstream Infections in Brazil: Results from A Prospective Countrywide Multicenter Study
巴西医疗保健相关血流感染中耐甲氧西林金黄色葡萄球菌的分子流行病学：一项前瞻性全国多中心研究的结果
Laura C. AntochevisLetícia O. SudbrackAlexandre P. Zavascki
Pages: 507 - 525
8
Long-Term Antibody Persistence After Hepatitis A Vaccination in Healthy Toddlers: Insights from Modeling
健康幼儿接种甲型肝炎疫苗后长期抗体持久性：基于模型的见解
Carlos EspulHéctor Horacio CuelloLaurent Coudeville
Pages: 527 - 538
9
Prevalence of Respiratory Syncytial Virus in Adult Patients with Respiratory Illnesses in Low to Middle-Income Countries: A Systematic Review and Meta-Analyses
中低收入国家成人呼吸道疾病患者中呼吸道合胞病毒的流行率：一项系统综述和荟萃分析
Digant GuptaAmandeep KaurAdriana Guzman-Holst
Pages: 539 - 559
10
Novel Diagnostic Marker Interleukin-33 for Invasive Pulmonary Aspergillosis in Acute-on-Chronic Liver Failure: A Proof-of-Concept Prospective Study
慢加急性肝衰竭合并侵袭性肺曲霉病的新型诊断标志物白细胞介素-33：一项概念验证前瞻性研究
Lanyue HuangMeng ZhangQin Ning
Pages: 561 - 576
11
Testing the Feasibility of a Self-Help Intervention That Includes Lymphatic Drainage to Reduce Fatigue-Related Symptoms Among Patients with Long COVID in General Practice: Experiences from Our Randomized Controlled Trial (RCT)
在全科医疗中测试包含淋巴引流以减轻长期新冠患者疲劳相关症状的自助干预措施的可行性：我们的随机对照试验（RCT）经验
Lisa RisteRaymond PerrinAdrian Heald
Pages: 577 - 589
12
Comparative Diagnostic Performance of the 36-Minute STANDARD M10 Fast Assay for Molecular Diagnosis of SARS-CoV-2, InfluenzaA and B, and Respiratory Syncytial Virus in Near-Patient Settings
36分钟STANDARD M10快速检测法在床旁检测中对SARS-CoV-2、甲型和乙型流感病毒以及呼吸道合胞病毒的分子诊断性能比较
Alexander DomnichGiada GarzilloGiancarlo Icardi
Pages: 591 - 604
13
Clinical Phenotypes of Critically Ill Patients with COVID-19 Infected with Omicron: A Nationwide Prospective Cohort Study
感染奥密克戎的危重症COVID-19患者的临床表型：一项全国性前瞻性队列研究
Etienne AudureauPierre Baythe SEVARVIR investigators
Pages: 605 - 628
Brief Report（简报）
14
How do Recent Population-Level RSVpreF Vaccine-Impact Results from the United Kingdom Relate to Previously Reported Vaccine Effectiveness Results?
英国最近公布的RSVpreF疫苗在人群层面的影响结果与之前报告的疫苗有效性结果有何关联？
Negar AliabadiQing LiuElizabeth Begier
Pages: 629 - 637
Case Report（病例报告）
15
Continuous Infusion of Aztreonam–Avibactam After High Loading Dose for an Infection Caused by an OXA-48- and NDM-1-Co-producing ST147 Klebsiella pneumoniae
针对OXA-48和NDM-1共产生的ST147型肺炎克雷伯菌感染，采用高负荷剂量后持续输注氨曲南-阿维巴坦
Paul Laffont-LozesFanny VillaRomaric Larcher
Pages: 639 - 649
Infectious Diseases and Therapy Volume 15, Issue 3
感染性疾病与治疗 15卷3期
https://link.springer.com/journal/40121/volumes-and-issues/15-3
Commentary（述评）
1
Taxonomy of the Full Health and Societal Value of Maternal Vaccination to Prevent Infant Respiratory Syncytial Virus Disease
预防婴儿呼吸道合胞病毒疾病中孕妇接种疫苗的全面健康及社会价值的分类学研究
J. P. SevillaDaria BurnesDavid E. Bloom
Pages: 651 - 682
Original Research（论著）
2
Characteristics of Haemophilus influenzae Isolates Responsible for Invasive Infections in Poland in 2018–2023
2018-2023年波兰引起侵袭性感染的流感嗜血杆菌分离株的特征
Marlena KiedrowskaKinga BłaszczykAnna Skoczyńska
Pages: 683 - 700
3
Evaluating the Effectiveness of 2024–2025 Seasonal mRNA-1273 Vaccination Against COVID-19-Related Hospitalizations and Medically Attended COVID-19 Among Adults Aged ≥ 18 years in the United States: An Observational Matched Cohort Study
评估2024-2025年季节性mRNA-1273疫苗对美国≥18岁成年人预防与COVID-19相关住院和就医的效力：一项观察性匹配队列研究
Nevena VicicAlina BogdanovAmanda Wilson
Pages: 701 - 714
4
Elevated Plasma GDF-15 Levels Are Associated with Aging, Multimorbidity, and Tobacco Exposure in People with HIV
HIV感染者中血浆GDF-15水平升高与衰老、多种合并症及烟草暴露相关
Aida López LópezJacobo Alonso DomínguezCoRIS Cohort
Pages: 715 - 731
5
High Burden of Febrile Sub-microscopic Plasmodium Mixed Infections in Central India: A Cross-Sectional Study
印度中部无症状疟原虫混合感染伴发热疾病负担高：一项横断面研究
Nimita DeoraVeena PandeAbhinav Sinha
Pages: 733 - 747
6
How Status Quo Bias Shapes Willingness, Uptake, and Adherence to PrEP Among Chinese MSM: A Behavioral Economics Perspective
从行为经济学视角看现状偏见如何影响中国男男性行为者对暴露前预防的意愿、接受度和依从性
Min ZhaoXiang ZhaoLei Zhang
Pages: 749 - 767
7
Immunogenicity and Safety of Quadrivalent Meningococcal Conjugate Vaccine (MenACYW-TT) in Potential Hajj/Umrah Pilgrims Aged≥56 Years: A Phase III, Open-Label Study
四价脑膜炎球菌结合疫苗（MenACYW-TT）在≥56岁潜在朝觐/副朝觐者中的免疫原性和安全性：一项III期、开放标签研究
Ghassan S. DbaiboIsmail BalikMehmet Ceyhan
Pages: 769 - 785
Part of 1 collection: Digital Features - Infectious Diseases
所属合集：数字专题 -传染病
8
Clinical Impact of Droplet Digital PCR-Guided Antibiotic Stewardship on Prognosis in Patients with Suspected Bloodstream Infection: A Prospective Observational Study
液滴数字PCR指导的抗生素管理对患者疑似血流感染预后的临床影响：一项前瞻性观察研究
Ziqiang ShaoJingwen ZhuBangchuan Hu
Pages: 787 - 807
9
Outpatient RSV Testing Rates Among US Adults with Lower Respiratory Tract Disease, 2017–2024
2017-2024年美国下呼吸道疾病成人患者门诊呼吸道合胞病毒检测率
Katherine K. PerezKashmira DateElizabeth Begier
Pages: 809 - 834
10
Role of Cefiderocol in the Treatment of Carbapenem-Resistant Nonfermenting Gram-Negative Bacilli (Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia) Infections: An Expert Statement
头孢地尔在治疗碳青霉烯类耐药非发酵革兰氏阴性杆菌（鲍曼不动杆菌、铜绿假单胞菌和嗜麦芽窄食单胞菌）感染中的作用：专家声明
Alexandre BleibtreuYoussef BennisCoRIS Cohort
Pages: 835 - 857
11
IgG4 Neutralization and Sustained Total IgG Fc-Effector Functions Following Repeated SARS-CoV-2 Vaccination with mRNA-1273
重复接种mRNA-1273疫苗后IgG4中和作用及总IgG Fc效应功能的持续存在
Paulina KaplonekHarry BerteraCarole Henry
Pages: 859 - 874
12
Rising Burden of Herpes Zoster among General Adults and Increased-Risk Groups in Eastern China, 2015–2021: A Population-Based Cohort Study
2015-2021年中国东部普通成人及高风险人群带状疱疹负担上升：一项基于人群的队列研究
Zhenwei LiShenjia GuChuanxi Fu
Pages: 875 - 888
13
Safety and Efficacy of Fecal Microbiota, Live-jslm for Prevention of Recurrent Clostridioides difficile Infection Among Hospitalized Participants in PUNCH CD3-OLS
PUNCH CD3-OLS研究中住院患者使用活菌粪便微生物群（Live-jslm）预防复发性艰难梭菌感染的安全性和有效性
Andrew M. SkinnerThomas P. LodiseJordan E. Axelrad
Pages: 889 - 901
Letter（读者来信）
14
Letter to the Editor Regarding “Advanced Liver Disease Events in People with HIV and Hepatitis B Virus Coinfection Initiating Antiretroviral Therapy in the United States”
致编辑的信：关于“美国HIV和乙型肝炎病毒合并感染者启动抗逆转录病毒治疗后发生晚期肝病事件”
Keiji Konishi
Pages: 903 - 905
15
A Response to: Letter to the Editor Regarding “Advanced Liver Disease Events in People with HIV and Hepatitis B Virus Coinfection Initiating Antiretroviral Therapy in the United States”
回复：致编辑的信——关于“美国HIV和乙型肝炎病毒合并感染者启动抗逆转录病毒治疗后发生晚期肝病事件”
Ching-Yi ChuoWoodie ZachryLi Tao
Pages: 907 - 909
16
A Response to: “Letter to the Editor regarding ‘Impact of Continuous Renal Replacement Therapy with Polyacrylonitrile-Derived Filter on Caspofungin Concentration: A Retrospective Study'”
回复：致编辑的信——关于“聚丙烯腈衍生滤器连续性肾脏替代治疗对卡泊芬净浓度的影响：一项回顾性研究”
Romain ArrestierKeyvan Razazi
Pages: 911 - 914
17
Letter to the Editor regarding 'Impact of Continuous Renal Replacement Therapy with Polyacrylonitrile-Derived Filter on Caspofungin Concentration: A Retrospective Study'
致编辑的信——关于“聚丙烯腈衍生滤器连续性肾脏替代治疗对卡泊芬净浓度的影响：一项回顾性研究”
Julien MassolValentin MauletFrédéric J. Baud
Pages: 915 - 919
Infectious Diseases and Therapy Volume 15, Issue 4
感染性疾病与治疗 15卷 4期
https://link.springer.com/journal/40121/volumes-and-issues/15-4
Review（综述）
1
Outpatient Parenteral Antimicrobial Therapy (OPAT) in Italy: A Scoping Review
意大利门诊静脉注射抗菌药物治疗（OPAT）：一项范围综述
Chiara MorealSimone GiulianoCarlo Tascini
Pages: 921 - 939
2
Reimagining Phage Therapy for MDR Pathogens: From Biobanks to Health System Integration—A Review
重新构想噬菌体疗法治疗多重耐药病原体：从生物银行到卫生系统整合——综述
Abay A. AyeleWenfeng LiuAbel A. Negash
Pages: 941 - 957
3
Navigating the Viral Hepatitis Drug Landscape: New Discoveries and Enduring Challenges. A Narrative Review
探索病毒性肝炎药物领域：新发现与持久挑战。一篇叙述性综述
He-ming SunXing-yu WangYan-hang Gao
Pages: 959 - 985
Original Research（论著）
4
Predictive Utility of the Pediatric-EQUAL Scale in Pediatric Candidemia Admitted to PICU Association with Clinical and Microbiological Factors Related Mortality
儿科-EQUAL量表对入住PICU的念珠菌血症患儿的预测效用：与临床和微生物学因素相关死亡率的关联
Muhterem DuyuAyşe Aşık
Pages: 987 - 1001
Publisher Correction（出版商更正）
5
Publisher Correction: Predictive Utility of the Pediatric-EQUAL Scale in Pediatric Candidemia Admitted to PICU Association with Clinical and Microbiological Factors Related Mortality
出版商更正：儿科-EQUAL量表对入住PICU的念珠菌血症患儿的预测效用：与临床和微生物学因素相关死亡率的关联
Muhterem DuyuAyşe Aşık
Pages: 1003 - 1005
Original Research（论著）
6
A Statistical Immune Correlates of Protection Model for Predicting Efficacy from Neutralizing Antibody Titers to Establish Immunobridging of Monoclonal Antibodies for Prevention of COVID-19
用于从中和抗体滴度预测疗效以建立预防新冠肺炎单克隆抗体免疫桥接的统计免疫保护相关因素模型
Ilker YalcinLeijun HuMark A. Wingertzahn
Pages: 1007 - 1017
7
Early Antibiotic Therapy in Sepsis Without Shock: A Multimethod Study of Heterogeneous Treatment Effects in ICU Patients
无休克性脓毒症的早期抗生素治疗：一项针对ICU患者异质性治疗效果的多方法研究
Peng ZhangTongkun ZuoYing Huang
Pages: 1019 - 1033
8
Post-marketing Safety Surveillance of 23-Valent Pneumococcal Polysaccharide Vaccine Administered Alone and Concomitantly with Influenza Vaccine in Individuals Aged 2Years and Older in China
中国2岁及以上人群单独接种及与流感疫苗同时接种23价肺炎球菌多糖疫苗的上市后安全监测
Yun-feng ShiLin-hang JuHong-xing Pan
Pages: 1035 - 1046
9
Cost-Effectiveness of Nirsevimab and Clesrovimab in Preventing Respiratory Syncytial Virus Lower Respiratory Tract Disease in Infants in the United States: A Modeling Study
美国预防婴儿呼吸道合胞病毒下呼吸道感染：Nirsevimab和Clesrovimab的成本效益——一项建模研究
Benjamin YarnoffMatthieu BeuveletLeonard R. Krilov
Pages: 1047 - 1073
10
Oritavancin in Complicated Bloodstream Infections and Endocarditis in Spain and Italy (ORIBAC Study): A Retrospective Multicenter Observational Study
西班牙和意大利奥利他万星治疗复杂血流感染和心内膜炎（ORIBAC研究）：一项回顾性多中心观察研究
Antonio VenaLaura MezzogoriORIBAC study group
Pages: 1075 - 1092
11
Mitigating Vaccine Disparities Through Faith-Based Intervention: A Pre-Post Analysis of Recombinant Zoster Vaccine Knowledge and Acceptance in Socially Vulnerable Racial and Ethnic Minoritized Communities
通过基于信仰的干预措施减轻疫苗差异：对社会弱势的种族和少数民族群体重组带状疱疹疫苗认知和接受度的前后分析
Jacinda C. Abdul-MutakabbirRaheem Abdul-MutakabbirSamuel J. Casey
Pages: 1093 - 1114
12
Epidemiological Burden and Hospitalization Trends of Human Metapneumovirus in Spain (2016–2023): A Retrospective Study
西班牙人类偏肺病毒的流行病学负担和住院趋势（2016 - 2023年）：一项回顾性研究
Oscar Brochado-KithRuth Gil-PrietoAngel Gil-de-Miguel
Pages: 1115 - 1135
13
Using Real-World Data to Support Claim Expansion of the Cobas SARS-CoV-2 Test in Asymptomatic Testing: Data from the National Football League Occupational Surveillance Program
使用现实数据支持Cobas SARS-CoV-2检测在无症状检测中的适用范围扩大：来自美国国家橄榄球联盟职业监测计划的数据
Baiyu YangErin B. WassermanElodie Baumfeld Andre
Pages: 1137 - 1148
Infectious Diseases and Therapy Volume 15, Issue 5
感染性疾病与治疗 15卷 5期
https://link.springer.com/journal/40121/volumes-and-issues/15-5
Review（综述）
1
Efficacy and Safety of Tetracyclines in Bone and Joint Infections: A Literature Review
四环素类药物治疗骨关节感染的有效性和安全性：文献综述
Paul Laffont-LozesRomaric LarcherAlbert Sotto
Pages: 1149 - 1174
2
The Ongoing Challenge of Pertussis in Eastern and Northern Europe: Recommendations from the Global Pertussis Initiative
东欧和北欧百日咳持续存在的挑战：全球百日咳倡议的建议
Mine Durusu TanrioverUlrich HeiningerKevin Forsyth
Pages: 1175 - 1201
3
Antibiotic Pharmacokinetics and Prostate Penetration in Bacterial Prostatitis: A Systematic Review
细菌性前列腺炎的抗生素药代动力学及前列腺穿透性：系统综述
Rui GeXinwen NianZhuo Wang
Pages: 1203 - 1248
4
Treatment for Dientamoeba fragilis: A Systematic Review and Meta-analysis
脆弱双核阿米巴病的治疗：系统综述和荟萃分析
Nadav BaharavMichael ItzkovichDafna Yahav
Pages: 1249 - 1262
Original Research（论著）
5
Preparing for Tuberculosis Vaccine M72/AS01E Implementation: A Global Demand Forecast and Key Influential Factors
结核病疫苗M72/AS01E实施准备工作：全球需求预测及关键影响因素
Judith KallenbergDominique MileaAgathe Philippot
Pages: 1263 - 1279
Correction（更正）
6
Correction: Preparing for Tuberculosis Vaccine M72/AS01E Implementation: A Global Demand Forecast and Key Influential Factors
更正：结核病疫苗M72/AS01E实施准备工作：全球需求预测及关键影响因素
Judith KallenbergDominique MileaAgathe Philippot
Pages: 1281 - 1281
Original Research（论著）
7
Impact of Nirsevimab on Pediatric RSV-Related Lower Respiratory Tract Infections: A Retrospective Pre–Post Observational Study in Tuscany, Italy
尼塞韦单抗对意大利托斯卡纳地区儿童呼吸道合胞病毒相关下呼吸道感染的影响：一项回顾性前后对照观察研究
Francesco NiedduMarta VerzieriMaria Moriondo
Pages: 1283 - 1295
8
Antiretroviral Therapy Switching Among People with HIV in the United States is not Uncommon Despite Virologic Suppression: An OPERA Cohort Study
尽管病毒学抑制，美国HIV感染者更换抗逆转录病毒疗法的情况并不少见：OPERA队列研究
Karam MounzerMichael D. OstermanGregory P. Fusco
Pages: 1297 - 1314
9
Role of Community Associations in HIV, HBV and HCV Screening and Support for Migrant Populations in France: Results of the DéPAC Study
社区协会在法国移民人群HIV、HBV和HCV筛查及支持中的作用：DéPAC研究结果
Dulce AlfaiateJean-Claude TardyFrançois Durand
Pages: 1315 - 1333
Part of 1 collection:Digital Features - Infectious Diseases
所属专题合集：数字专题-传染病
10
Impact of Risk Factor Combinations on Severe COVID-19 Outcomes Among Outpatients
风险因素联合作用对门诊患者严重新冠肺炎预后的影响
Haley J. AppanealVrishali V. LopesAisling R. Caffrey
Pages: 1335 - 1351
11
Clinical Outcomes Among Older Adults Hospitalized with Respiratory Syncytial Virus and Influenza Infection: A Retrospective Analysis
老年住院患者呼吸道合胞病毒和流感病毒感染的临床预后：一项回顾性分析
Menucha JurkowiczIli MargalitMichal Mandelboim
Pages: 1353 - 1367
12
The Impact and Effectiveness of a Two-Dose Varicella Immunization Program Among School Children: Evidence from Quasi-experimental Analyses
两剂水痘免疫接种计划对学龄儿童的影响和有效性：来自准实验分析的证据
Huiqiao GuXu XieYawen Jiang
Pages: 1369 - 1384
13
Lessons Learned: Defining the Right Specifications for Diagnostics in Outbreak Situations
经验教训：疫情情况下确定诊断的正确规范
Markus BeutlerPablo BonvehíAndreas Wieser
Pages: 1385 - 1399
14
Post-COVID-19 Burden of Severe Influenza in England Among Overall Population and High-Risk Groups: Results From the INFORM Study, 2022–2023
2022-2023年INFORM研究结果：英格兰地区普通人群和高危人群中新冠肺炎后严重流感的负担
Wilhelmine MeerausLucy CartyLance Turtle
Pages: 1401 - 1424
15
Respiratory Syncytial Virus Immunization Strategies for Older Adults in Gulf Cooperation Council Countries: Expert Consensus and Recommendations
海湾合作委员会国家老年人呼吸道合胞病毒免疫接种策略：专家共识和建议
Nawal AlKaabiMohammed AbukhattabSalah Al Awaidy
Pages: 1425 - 1449
16
Prospective Study of Treatment with Ensitrelvir for COVID-19 in Patients Undergoing Hemodialysis (PROTECT-HD)
血液透析患者使用恩赛特韦治疗新冠肺炎的前瞻性研究（PROTECT-HD）
Mineaki KitamuraTakahiro TakazonoHiroshi Mukae
Pages: 1451 - 1466
17
Diagnostic Performance and Clinical Outcomes of Pertussis in Hospitalized Children in Relation to Available Vaccination Status: A Retrospective Cohort Study
在现有疫苗接种情况下，住院患儿百日咳的诊断性能和临床预后：一项回顾性队列研究
Dominika LachowiczBarbara JastrzębskaEdyta Podsiadły
Pages: 1467 - 1477
18
Demonstrating Clinical Performance of the Elecsys Anti-SARS-CoV-2 Anti-Nucleocapsid Immunoassay Using Real-World Data to Support Regulatory Decision-Making in the USA
使用现实数据证明Elecsys抗SARS-CoV-2抗核衣壳免疫检测的临床性能，以支持美国监管决策
Eldad A. HodBaiyu YangElodie Baumfeld Andre
Pages: 1479 - 1491
19
Efficacy and Safety of Glecaprevir/Pibrentasvir in Participants with Chronic HCV Infection and Comorbidities or Multiple Concomitant Medications: An Integrated Analysis
格卡瑞韦/哌仑他韦治疗慢性丙型肝炎病毒感染且伴有合并症或多种合并用药受试者的有效性和安全性：一项综合分析
Curtis CooperShweta A. RainaStanislas Pol
Pages: 1493 - 1508
20
Modeling the Public Health Impact of Introducing 4CMenB Vaccination for Infants in the Brazilian National Immunization Program
在巴西国家免疫计划中引入4CMenB疫苗对公共卫生的影响建模
Thatiana PintoZeki KocaataElise Kuylen
Pages: 1509 - 1524
21
Multicenter Real-World Outpatient Use of Intravenous Omadacycline
门诊使用静脉注射奥马环素的多中心现实情况
Lucinda J. Van AnglenCathy L. KooKimberly A. Couch
Pages: 1525 - 1538
22
Burden of Respiratory Syncytial Virus in Older ADults in Nagasaki, Japan (Nagasaki ROAD): Preliminary Results (April 2024–March 2025) of a Prospective, Multicenter, Epidemiological Study
日本长崎地区老年人呼吸道合胞病毒负担（长崎ROAD）：一项前瞻性、多中心、流行病学研究的初步结果（2024年4月-2025年3月）
Takahiro TakazonoNorihito KakuHiroshi Mukae
Pages: 1539 - 1564
Brief Report（简报）
23
Effectiveness of Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide from Rilpivirine or Other Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI)-Based Antiretroviral Therapy in Virologically Suppressed People with HIV: A Retrospective Analysis (DRIVE-SWITCH Study)
对于病毒学抑制的HIV感染者，从利匹韦林或其他非核苷类逆转录酶抑制剂（NNRTI）为基础的抗逆转录病毒疗法转换为比克替拉韦/恩曲他滨/丙酚替诺福韦的有效性：一项回顾性分析（DRIVE-SWITCH研究）
Roberta GagliardiniAlessandro CaioliAndrea Antinori
Pages: 1565 - 1575
Infectious Diseases and Therapy Volume 15, Issue 6
感染性疾病与治疗 15卷 6期
https://link.springer.com/journal/40121/volumes-and-issues/15-6
Commentary（述评）
1
Adult RSV Vaccination: What Is the Role of RSV Subgroup in Disease Prevention?
成人RSV疫苗接种：RSV亚群在疾病预防中的作用是什么？
S. Elizabeth WilliamsGiovanni Checcucci LisiElizabeth Begier
Pages: 1577 - 1587
Review（综述）
2
Epidemiology of Acute Cystitis or Afebrile Urinary Tract Infection in Adult Men: A Systematic Literature Review
成年男性急性膀胱炎或无热尿路感染的流行病学：一项系统文献综述
Mary E. GeorgiouPriscilla WittkopfFanny S. Mitrani-Gold
Pages: 1589 - 1606
3
Non-intravenous Amphotericin B: A Review of Localized Administration Routes
非静脉注射两性霉素B：局部给药途径综述
Francelise Bridi CavassinLaura Fernanda RodriguesMarcello Mihailenko Chaves Magri
Pages: 1607 - 1632
4
Infections Caused by Fusobacterium Species: Microbiology, Clinical Syndromes and Management: A Narrative Review
Fusobacterium属引起的感染：微生物学、临床综合征及治疗：一篇叙述性综述
Michal ParetGuy KatzenellenbogenDafna Yahav
Pages: 1633 - 1647
5
When Culture Results Don’t Tell the Whole Story: A Practical Review of Antibiotics Pitfalls for Clinical Decision-Making
当培养结果不能说明全部问题：临床决策中抗生素陷阱的实用综述
Ahmed M. ShomanAyman A. Radwan
Pages: 1649 - 1667
Original Research（论著）
6
Cost-Effectiveness of Alternative Immunization Strategies to Protect Infants Against Respiratory Syncytial Virus in Germany: A Decision Modeling Study
德国保护婴儿免受呼吸道合胞病毒感染的替代免疫策略的成本效益：一项决策模型研究
Caroline LadeErin QuinnAhuva Averin
Pages: 1669 - 1687
7
Estimation of Costs Related to the Management of Herpes Zoster and its Complications in Vietnam: A Medical Chart Review
越南带状疱疹及其并发症治疗相关费用估算：一项病历回顾研究
Nurilign AhmedVan M. NguyenHuong T. T. Nguyen
Pages: 1689 - 1704
8
Validation of the VIRSTA and VIRSTA+ Scores to Identify Patients with Staphylococcus aureus Bacteremia at Very Low Risk of Infective Endocarditis
VIRSTA和VIRSTA+评分验证以识别感染性心内膜炎极低风险的金黄色葡萄球菌菌血症患者
Daniela Malano-BarlettaMiguel Ángel VerdejoAlex Soriano
Pages: 1705 - 1718
9
The Shifting Landscape of HIV–Tuberculosis Co-Infection in the MENA Region with a Focus on Saudi Arabia: A Systematic Epidemiological Analysis over Three Decades
MENA地区HIV–结核共感染的变化格局：以沙特阿拉伯为重点的三十年系统流行病学分析
Zikria SaleemMasaad Saeed AlmutairiFaris S. Alnezary
Pages: 1719 - 1731
10
Comprehensive Analysis of Health Service Utilization for Febrile Illness and Malaria in Malaria-Endemic States in India: LLINs as a Pillar of Control Strategies
印度疟疾流行邦发热疾病和疟疾卫生服务利用的综合分析：长效杀虫蚊帐作为控制策略的支柱
Vani H. ChalageriShrinivasa B. MarinaikAnupkumar R. Anvikar
Pages: 1733 - 1746
11
Observational, Post-marketing Surveillance of Safety and Effectiveness of Glecaprevir/Pibrentasvir in Korean Patients with Chronic Hepatitis C
格卡瑞韦/匹布他韦在韩国慢性丙型肝炎患者中的观察性上市后安全性和有效性监测
Jin-Woo LeeSang Hoon AhnJeong Heo
Pages: 1747 - 1761
12
Post-Marketing Active Surveillance of Adverse Events Following Quadrivalent Subunit Influenza Vaccine in Healthy Participants Aged≥3 Years in China
中国≥3岁健康人群接种四价亚单位流感疫苗后不良事件的上市后主动监测
Mingwei WeiYu PanHongxing Pan
Pages: 1763 - 1778
Systematic Review（系统综述）
13
Point-of-Care Nucleic Acid Amplification Tests for Respiratory Syncytial Virus Detection in Children and Adults: A Systematic Literature Review
用于儿童和成人呼吸道合胞病毒检测的即时核酸扩增检测：一项系统文献综述
Kashmira DateKyle FowlerElizabeth Begier
Pages: 1779 - 1799
Correction（勘误）
14
Correction: The Cefazolin Inoculum Effect: An Underappreciated Factor in MSSA Treatment Strategies
勘误：头孢唑林接种效应：MSSA治疗策略中被低估的因素
Prakhar SrivastavaElizabeth SingletonRazieh Kebriaei
Pages: 1801 – 1801
微生物疗法临床结果临床1期
2026-05-30
M100 微阵列生物芯片点样仪：小分子化合物/蛋白质/多肽/核酸/多糖高通量筛选
高通量芯片点样仪(6块SBS进样板/100片标准载玻片)
英国ArrayJet公司：
成立于2000年，总部位于英国爱丁堡；
专注于超微量生物芯片和高通量筛选应用领域的解决方案及服务；
作为高通量微阵列生物芯片点样仪的制造厂商，全球客户群体广泛，从世界500强企业到一流科研学术机构；
产品介绍：
M100 微阵列生物芯片点样仪
行业标杆的快速、非接触式超微量液体处理
可同时进行上万种不同样品的快速点样
独特的上样模块配合高通量的点样喷头，保障点样速度快、样品无污染
制备高密度的蛋白质、抗体、多糖、小分子化合物、核酸等各种微阵列芯片
用于高通量筛选，如自身免疫抗体、生物标记物、候选疫苗、药物靶点等
技术原理：
独特的进样技术：相比传统的吸液喷液一体式喷头，独立的进样针和喷头的设计保证清洗更彻底，通量更高、点样更灵活。
技术原理
点样流程
产品特点：
速度快：点样速度711个样片点／秒
通量高：单次进行18432种不同样品的快速点样，具备128个平行喷点通道
精度高： CV < 5%（可实现精准的点上点样，实现微型的点对点ELISA反应）
完整的环境控制模块以及防样品蒸发保护（大幅降低点样过程中样品浓度变化）
应用方向：
基因芯片：高通量分子互作验证、疾病功能基因检测或筛选等
蛋白质芯片：高通量功能蛋白质筛选、抗原表位筛选、生物靶点筛选等
多糖芯片：进行高通量糖功能学、糖蛋白、植物凝集素等研究等
小分子化合物芯片：高通量药物筛选、疾病研究、疾病标志物筛选等
微阵列SRPi镀金芯片：高通量分子互作研究等
微孔板芯片：高通量多重因子检测、微型ELISA等
微流控芯片、生物传感器芯片：药物研发、体外诊断、生物半导体研发等
临床快检POCT芯片：抗原抗体检测、过敏原检测、病原微生物检测等
应用案例：
1. 蛋白质芯片-新冠病毒抗体研究
作者：上海交通大学系统生物医学研究院
应用：采用Arrayjet Super Marathon（对应新型号M 100-S）高通量微阵列生物芯片点样仪在硝化纤维素(NC)载玻片上进行病毒重组蛋白点样，该芯片涵盖了14个新冠病毒基因组所编码的蛋白质，随后孵育荧光标记的自身免疫抗体，最后用荧光芯片扫描仪进行数据分析，为新冠病毒诊断，愈后评估和疫苗开发提供有价值的线索.
SARS-CoV-2 proteome microarray for global profiling of COVID-19 specific IgG and IgM responses（Nature Communications, 2020）
2. 小分子化合物芯片-RNA酶结合位点筛选
作者：美国国家癌症研究所化学生物学实验室
应用：作者使用ArrayJet微阵列生物芯片点样仪将7000种小分子化合物点印到环氧修饰的玻片上，制备高通量小分子化合物微阵列芯片，通过研究发现了一种可以下调DHX15蛋白表达的化合物，该方法为新药研发过程即从靶标识别到先导化合物的发现提供了一种新的研究策略。
Competitive Microarray Screening Reveals Functional Ligands for the DHX15 RNA G-quadruplex（ACS Medicinal Chemistry Letters, 2025）
3. 多糖芯片-藻类多糖的降解机制研究
作者：德国不来梅大学海洋环境科学研究中心
应用：作者使用英国ArrayJet微阵列生物芯片点样仪进行多糖微阵列点样，对微生物促进藻类多糖的降解机制进行研究
Marine bacteroidetes use a conserved enzymatic cascade to digest diatom β-mannan（The ISME Journal 2023）
4. 核酸芯片-癌症相关靶点筛选
作者：维也纳大学物理与化学学院
应用：使用ArrayJet微阵列生物芯片点样仪将捕获探针点印在镀金芯片上，通过与荧光标记的突变型和野生型DNA进行杂交，对乳腺癌靶点进行筛选.
Detection of breast cancer-related point-mutations using screen-printed and gold-plated electrochemical sensor arrays suitable for point-of-care applications（Talanta Open 2022）
典型客户：
发表文献：
2025.10 德国不来梅大学 - 马克斯・普朗克海洋微生物研究所分子生态学系 Carbohydrates, enzyme activities, and microbial communities across depth gradients in the western North Atlantic Ocean 多糖芯片
2025.10 牛津大学热带医学与全球健康中心 Long-term dynamics of cytomegalovirus-specific antibodies in a longitudinal cohort of children followed up for the first decade of life 蛋白质芯片
2025.09 英国曼彻斯特大学免疫与炎症研究所 Evaluation of Immunization Route in Induction of Vaccine-Mediated Anti-Gonococcal Immune Responses in a Murine Model of Ascending Infection 蛋白质芯片
2025.09 首都医科大学，北京朝阳医院急诊医学中心，心肺脑复苏北京市重点实验室 Immunoglobulin glycosylation profiling for early identification of patients with severe influenza pneumonia 多糖凝集素芯片
2025.08 中国科学院生物物理研究所生物大分子国家实验室，深圳高新技术大学合成生物学院 An African swine fever virus-specific antibody reactome reveals antigens as potential candidates for vaccine development 蛋白质芯片
2025.08 奥地利科学院分子生物技术研究所 CLEC18A interacts with sulfated glycosaminoglycans and controls clear cell renal cell carcinoma progression 多糖芯片
2025.07 挪威生命科学大学生物科学学院 Protozoal populations drive system-wide variation in the rumen microbiome 多糖芯片
2025.07 萨尔茨堡巴黎洛德隆大学分子植物生理学、环境与生物多样性系 Arabinokinase Limits the Flux of Arabinose Into Nucleotide Sugars to Prevent Toxicity 多糖芯片
2025.07 西班牙萨拉曼卡 - CSIC 大学癌症研究中心 Humoral Response Profile in SARS-CoV-2 Infection: Differences across Virus Strains and Influenza 蛋白质芯片
2025.06 牛津大学热带医学与全球健康中心，肯尼亚医学研究所 A natural experiment in Kenya reveals durable immunosuppressive effects of early childhood malaria: a longitudinal cohort study 蛋白质芯片
2025.06 中国科学院海洋研究所，中国科学院海洋生态与环境重点实验室 Establishment of CARD-FISH and Dot-ELISA Assays for Diagnosis of the Parasitic Dinoflagellate Hematodinium perezi 蛋白质芯片
2025.05 内蒙古农业大学生命科学学院 Lactate metabolism antagonizes antiviral innate immunity by promoting VDAC1-lactylation-mediated mtDNA release 蛋白质芯片
2025.04 中国热带农业科学院热带作物遗传资源研究所 Mutation of the Polygalacturonase Gene AcoPG3 Deferred Softening of Pineapple Fruit 蛋白质芯片
2025.04 意大利 GSK 全球卫生疫苗研究所 Isolation of human monoclonal antibodies from 4CMenB vaccinees reveals PorB and LOS as the main OMV components inducing cross-strain protection 蛋白质芯片
2025.04 瑞士巴塞尔诺华制药公司生物医学研究中心 Exercise-Induced Myostimulin Enhances Muscle Function in Health and Disease 蛋白质芯片
2025.04 丹麦哥本哈根大学植物与环境科学系 Comparative transcriptomics in ferns reveals key innovations and divergent evolution of the secondary cell walls 多糖芯片
2025.04 西班牙穆尔西亚大学兽医学院食品科学与技术系 Grape Pomace Fibres as a Sustainable Fining Agent to Ensure Red Wine Safety: A First Approach in a Continuous System 多糖芯片
2025.04 曼彻斯特大学生物医学与健康学院 Identification of immunogenic outer membrane vesicle vaccine antigen components using a meningococcal protein microarray 蛋白质芯片
2025.03 北京大学肿瘤医院肿瘤研究所黑色素瘤与肉瘤科，癌变与转化研究教育部重点实验室 Dynamic Change of PD-L2 on Circulating Plasma Extracellular Vesicles as a Predictor of Treatment Response in Melanoma Patients Receiving Anti-PD-1 Therapy 蛋白质芯片
2025.01 美国俄亥俄州立大学生物化学研究所 Use of a small molecule microarray screen to identify inhibitors of the catalytic RNA subunit of Methanobrevibacter smithii RNase P 小分子化合物芯片
2025.01 西班牙巴利亚多利德大学医院微生物科 Assessment of Humoral Response at SARS-CoV-2 Infection by Multipronged Functional Proteomics Approaches 蛋白质芯片技术原理
100 项与 B群脑膜炎球菌疫苗(Novartis Pharma AG) 相关的药物交易
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临床结果
临床结果
适应症
分期
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床3期 | 1,196 | 遞構鏇憲壓壓獵膚範鑰 = 壓襯鏇鬱糧窪製繭獵範 艱選糧衊蓋簾襯願夢顧 (憲衊鏇範襯蓋築齋壓艱, 繭鹹製廠繭鏇製獵憲衊 ~ 蓋範鹽構選積構襯網糧) 更多 | - | 2026-02-10 | |||
糧衊衊築廠顧選餘構遞 = 淵膚獵襯鏇淵廠繭窪鏇 遞齋顧觸蓋壓簾觸範範 (蓋衊築積淵製憲衊糧壓, 遞窪醖齋獵鏇餘糧遞鬱 ~ 構簾選齋窪壓艱窪膚衊) 更多 | |||||||
临床3期 | 945 | 夢顧願觸齋遞襯鹽夢憲 = 遞遞獵觸簾選壓鬱構餘 餘衊齋積鑰艱構繭蓋獵 (繭觸鹹襯製餘窪鹹繭膚, 範範餘觸繭獵築網顧製 ~ 廠製鏇醖窪艱鹽艱艱蓋) 更多 | - | 2025-03-04 | |||
夢顧願觸齋遞襯鹽夢憲 = 築艱壓鬱蓋窪膚齋鏇廠 餘衊齋積鑰艱構繭蓋獵 (繭觸鹹襯製餘窪鹹繭膚, 鬱鹽醖齋鹽願構餘齋選 ~ 餘膚窪夢憲網廠餘獵鹽) 更多 | |||||||
临床2期 | 52 | (4CMenB) | 範繭選鹹衊製齋廠範淵(獵壓遞衊艱遞衊網範鹹) = 淵壓醖衊觸夢願餘鬱選 餘憲觸艱遞範齋壓簾憲 (鏇蓋鑰網蓋憲鑰鏇鏇蓋, 築淵顧蓋艱壓鏇構鏇獵 ~ 醖窪顧蓋糧鏇餘糧衊膚) 更多 | - | 2024-11-05 | ||
Placebo (Placebo) | 範繭選鹹衊製齋廠範淵(獵壓遞衊艱遞衊網範鹹) = 鹽鏇壓夢選願鹽壓廠製 餘憲觸艱遞範齋壓簾憲 (鏇蓋鑰網蓋憲鑰鏇鏇蓋, 窪襯淵遞構顧積夢選顧 ~ 簾獵襯鹽繭顧遞製廠糧) 更多 | ||||||
临床4期 | 129 | 4CMenBomponent meningococcal B vaccine (4CMenB 2+1 schedule) | 壓窪夢鑰廠壓選顧鏇顧(膚鑰齋構鏇製齋範蓋餘) = 網壓願遞獵製糧淵餘獵 製繭衊壓淵鬱築製窪範 (淵構簾範簾糧壓鹽獵醖 ) | 积极 | 2024-11-01 | ||
4CMenBomponent meningococcal B vaccine (4CMenB 3+1 schedule) | 壓窪夢鑰廠壓選顧鏇顧(膚鑰齋構鏇製齋範蓋餘) = 鹽艱淵壓鹽築襯醖鹽夢 製繭衊壓淵鬱築製窪範 (淵構簾範簾糧壓鹽獵醖 ) | ||||||
临床4期 | 1,021 | (rMenB+OMV NZ Group) | 齋選衊製膚窪窪鏇觸願 = 顧鑰夢衊範選襯網憲簾 鏇壓築膚觸糧壓衊鑰襯 (遞顧齋襯窪顧膚糧醖獵, 膚淵艱憲廠網鑰築鬱鬱 ~ 襯襯築簾範憲鹽製窪蓋) 更多 | - | 2023-07-17 | ||
(MenACWY 1 Group) | 齋選衊製膚窪窪鏇觸願 = 糧夢網壓壓壓壓壓壓廠 鏇壓築膚觸糧壓衊鑰襯 (遞顧齋襯窪顧膚糧醖獵, 衊鹽獵構齋窪選鹽窪鬱 ~ 襯製鬱繭醖鑰膚積鬱餘) 更多 | ||||||
临床4期 | 11 | 壓繭築廠遞醖廠鏇齋構(夢觸遞網鹽簾壓鹹衊憲) = 窪願鬱憲艱膚淵築鬱鑰 壓憲願憲鬱顧衊繭鏇窪 (顧願齋艱獵壓艱鑰顧夢, 網範廠顧顧齋繭淵選醖 ~ 鹽衊憲窪窪鹹鑰積糧觸) 更多 | - | 2021-07-15 | |||
临床4期 | 34,489 | (Control group (not vaccinated)) | 構觸繭積蓋鑰顧鏇艱網(簾憲觸鬱膚積鹽觸膚憲) = 衊顧繭廠構糧積壓鬱餘 願願構夢壓壓齋願範壓 (廠糧顧遞築獵淵襯遞衊 ) | 积极 | 2021-02-15 | ||
临床4期 | - | 34,489 | 鑰願鹽醖製鹹壓簾廠糧(糧獵構廠製襯餘鬱蓋願) = 鬱願餘繭廠壓顧範獵鑰 製鹹網醖構鬱範網衊夢 (壓鏇憲蓋築蓋築餘夢範, 0.28 ~ 0.39) 更多 | - | 2020-08-18 | ||
临床4期 | 34,489 | 艱鏇夢蓋鹹蓋鑰網鑰齋(衊蓋鏇簾鹽窪膚膚艱蓋) = 憲廠醖蓋憲獵廠繭齋艱 窪憲憲觸範簾窪壓糧遞 (鹹衊製鏇簾願製餘窪選 ) | 不佳 | 2020-01-23 | |||
No Intervention | 艱鏇夢蓋鹹蓋鑰網鑰齋(衊蓋鏇簾鹽窪膚膚艱蓋) = 築遞齋鑰遞遞鬱憲鑰壓 窪憲憲觸範簾窪壓糧遞 (鹹衊製鏇簾願製餘窪選 ) | ||||||
临床2期 | 604 | (ABCWY_0_2) | 顧憲鬱膚遞廠夢鏇獵膚 = 遞鬱築艱齋襯鹹積範窪 鑰積範鹽獵壓廠齋窪選 (願選壓鑰衊鏇觸艱獵選, 簾築構夢窪鹽積蓋鏇構 ~ 鏇蓋繭獵夢繭積鬱遞簾) 更多 | - | 2019-08-20 | ||
(ABCWY_0_2_6) | 顧憲鬱膚遞廠夢鏇獵膚 = 鏇築餘繭鹹憲鬱遞廠獵 鑰積範鹽獵壓廠齋窪選 (願選壓鑰衊鏇觸艱獵選, 鬱網窪獵齋夢醖鏇築醖 ~ 鹽簾憲網餘鹽衊餘衊觸) 更多 |
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