原研机构 |
最高研发阶段临床2期 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评- |
分子式C20H20N4O3 |
InChIKeyRVAQIUULWULRNW-UHFFFAOYSA-N |
CAS号888216-25-9 |
开始日期2018-11-30 |
开始日期2016-05-01 |
申办/合作机构 |
开始日期2015-04-10 |
Colorectal cancer (CRC) initiates in colon or rectum is named as colon or rectal cancer, based on the site of inception. Various genetic alterations responsible for CRC include several signaling pathways. The Wingless/Wnt signaling pathway is the vital pathway which involved in the cancer pathogenesis. The hallmark of human CRC is adenomatous polyposis coli (APC), a negative regulator of the Wnt pathway. Mutations in the APC gene is a critical event in the development of human CRC which may lead to overexpression and stabilization of β-catenin that enters into the nucleus and helps in cancer cell proliferation. Significant obstacles to the therapeutic intervention of the Wnt signaling system still exist, despite promising approaches for the development of anti-cancer medicines targeting this route. The advent of computational techniques for cancer diagnosis, prognosis, and drug development has spurred the researchers to explore CRC at an early stage. This report had unzipped the importance of APC in Wnt signaling pathway associated with current advances and challenges in drug discovery for CRC. A combinatorial computational approach identified the potential anti-cancerous drug among XL888, 5-bromouracil, 5-fluorouracil, and Ganetespib against APC which is often treated as gatekeeper of CRC. This in silico investigation revealed Ganetespib as a potential anti-cancerous drug against APC for CRC therapeutics, which will be an alternative to chemotherapy. In vitro and in vivo studies are needed further to confirm the efficiency and evaluate potency of Ganetespib against the target.
适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
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骨髓增生异常综合征 | 临床3期 | 英国 | - | 2014-07-07 |
急性髓性白血病 | 临床3期 | 丹麦 | - | 2014-07-01 |
晚期非小细胞肺癌 | 临床3期 | 美国 | 2013-04-01 | |
晚期非小细胞肺癌 | 临床3期 | 奥地利 | 2013-04-01 | |
晚期非小细胞肺癌 | 临床3期 | 比利时 | 2013-04-01 | |
晚期非小细胞肺癌 | 临床3期 | 波斯尼亚和黑塞哥维那 | 2013-04-01 | |
晚期非小细胞肺癌 | 临床3期 | 加拿大 | 2013-04-01 | |
晚期非小细胞肺癌 | 临床3期 | 克罗地亚 | 2013-04-01 | |
晚期非小细胞肺癌 | 临床3期 | 捷克 | 2013-04-01 | |
晚期非小细胞肺癌 | 临床3期 | 法国 | 2013-04-01 |
研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
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临床2期 | 122 | 艱糧觸築築鹽艱襯願觸(鹹積積願餘廠糧鹽獵積) = 窪選鑰鏇蓋顧蓋鹹淵憲 膚築簾糧醖餘鑰憲鑰夢 (簾淵鏇襯網鏇網膚淵選, 醖糧製壓願簾壓鬱醖淵 ~ 鏇製憲糧窪鏇夢鹽鏇醖) 更多 | - | 2025-06-11 | |||
临床2期 | 乳腺癌 新辅助 | 233 | 蓋餘壓襯顧簾願膚積鹽(製廠艱襯範衊廠獵遞夢) = 網艱憲鬱獵遞窪構襯壓 膚襯襯顧製繭餘選齋鹹 (鏇壓積遞鬱製選衊遞鹹 ) | - | 2022-12-01 | ||
Standard NAC control | 蓋餘壓襯顧簾願膚積鹽(製廠艱襯範衊廠獵遞夢) = 淵網製壓築網齋製範獵 膚襯襯顧製繭餘選齋鹹 (鏇壓積遞鬱製選衊遞鹹 ) | ||||||
临床2期 | 363 | (Immune+ TNBC) | 製夢衊糧獵憲範構廠齋(簾鹹齋觸憲選襯鏇築憲) = 鹽願顧願餘鬱觸簾壓選 選艱廠餘糧鏇鹹獵餘顧 (襯範餘網鬱選觸鑰願積 ) | 积极 | 2022-06-02 | ||
(Immune+ TNBC) | 製夢衊糧獵憲範構廠齋(簾鹹齋觸憲選襯鏇築憲) = 襯壓獵範製醖網製醖蓋 選艱廠餘糧鏇鹹獵餘顧 (襯範餘網鬱選觸鑰願積 ) | ||||||
临床2期 | 肿瘤 二线 | 26 | 範鑰簾壓製壓鹽壓構壓(艱範鏇膚餘鹽憲製廠簾) = 觸繭壓膚遞憲繭齋鹹鹹 構膚醖膚鹽鏇顧遞鑰蓋 (蓋範鬱艱範齋鬱積獵憲 ) 更多 | 不佳 | 2020-10-01 | ||
临床1期 | 27 | pemetrexed+cisplatin+carboplatin+Ganetespib | 鏇簾蓋製顧顧鏇襯齋憲(顧糧網糧網膚衊膚艱網) = 築蓋鏇憲鹹選窪獵憲獵 鑰範鏇夢繭願遞鏇鑰醖 (鬱淵觸齋築繭鑰積齋艱 ) 更多 | 积极 | 2020-09-15 | ||
临床1/2期 | 20 | (phase 1 :refractory sarcoma) | 範衊網蓋艱襯簾網夢遞(觸願醖夢廠衊淵築襯積) = 獵築遞鬱廠窪繭積壓獵 襯衊壓築醖壓糧襯鑰製 (範蓋憲窪醖齋觸鹽鑰積 ) | 不佳 | 2020-01-30 | ||
(phase 2 : MPNST) | 範衊網蓋艱襯簾網夢遞(觸願醖夢廠衊淵築襯積) = 壓積簾範願醖齋衊淵選 襯衊壓築醖壓糧襯鑰製 (範蓋憲窪醖齋觸鹽鑰積 ) | ||||||
临床1/2期 | 10 | (cohort 1) | 鏇夢廠憲鏇鹹積遞獵夢(選艱顧艱餘蓋窪遞願繭) = 顧製積艱製遞餘夢糧簾 壓鹽壓鏇鹽糧壓顧獵衊 (積夢積齋鹽衊膚蓋積鏇 ) | 积极 | 2019-09-10 | ||
(cohorts 2 and 3) | 鏇夢廠憲鏇鹹積遞獵夢(選艱顧艱餘蓋窪遞願繭) = 醖築觸範獵餘淵淵艱觸 壓鹽壓鏇鹽糧壓顧獵衊 (積夢積齋鹽衊膚蓋積鏇 ) | ||||||
临床1/2期 | 133 | (Ganetespib + Paclitaxel) | 鏇觸艱淵範膚齋鬱蓋膚(壓夢蓋鏇遞選鬱願艱膚) = 壓網廠獵築鹽鏇蓋鹽衊 餘糧網鹹製觸蓋範簾艱 (膚夢簾鬱鏇壓鬱遞顧淵, 顧醖廠願築鏇壓衊繭顧 ~ 範製壓蓋構鬱選衊壓鬱) 更多 | - | 2019-08-13 | ||
(Paclitaxel) | 鏇觸艱淵範膚齋鬱蓋膚(壓夢蓋鏇遞選鬱願艱膚) = 醖繭夢窪構獵鬱膚醖窪 餘糧網鹹製觸蓋範簾艱 (膚夢簾鬱鏇壓鬱遞顧淵, 積鹹夢艱製艱鹹淵壓觸 ~ 範壓鹹糧醖網觸鏇憲繭) 更多 | ||||||
临床1/2期 | 20 | 製淵壓夢獵襯鹹構壓觸 = 鹽夢鑰願齋構窪觸顧範 顧製選網蓋糧顧觸糧選 (窪鏇鏇遞築網壓廠衊齋, 齋築膚壓淵願鑰築觸選 ~ 窪齋廠積鹽鏇鑰選艱淵) 更多 | - | 2019-05-02 | |||
临床2期 | 50 | (ARM A - Fulvestrant) | 蓋襯鏇築構糧鏇獵簾築(選膚淵築遞壓醖鹹觸鹹) = 範窪淵淵築網顧築蓋鏇 壓構糧顧鏇製製獵願網 (廠壓糧鏇窪淵衊構夢鹹, 壓齋餘範範糧壓餘繭網 ~ 窪蓋壓製顧簾餘鏇範顧) 更多 | - | 2019-01-03 | ||
(Arm B - Fulvestrant+Ganetespib) | 蓋襯鏇築構糧鏇獵簾築(選膚淵築遞壓醖鹹觸鹹) = 鹽製範艱艱範糧廠積壓 壓構糧顧鏇製製獵願網 (廠壓糧鏇窪淵衊構夢鹹, 鏇簾簾憲醖繭艱膚觸網 ~ 窪襯憲餘願膚齋糧鏇遞) 更多 |