预约演示
更新于：2026-09-20
Sichuan University
更新于：2026-09-20
概览
标签
肿瘤
消化系统疾病
其他疾病
小分子化药
蛋白水解靶向嵌合体（PROTAC）
化学药
疾病领域得分
一眼洞穿机构专注的疾病领域
技术平台
公司药物应用最多的技术
靶点
公司最常开发的靶点
关联
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在研机构 |
原研机构 |
在研适应症 |
非在研适应症 |
最高研发阶段 |
首次获批国家/地区 |
首次获批日期 |
靶点 |
作用机制 |
在研机构 |
原研机构 |
在研适应症 |
非在研适应症 |
最高研发阶段 |
首次获批国家/地区 |
首次获批日期 |
靶点 |
作用机制 |
在研机构 |
原研机构 |
在研适应症 |
非在研适应症 |
最高研发阶段 |
首次获批国家/地区 |
首次获批日期 |
NCT07258147
Clinical Study on the Efficacy and Safety of Radiotherapy Combined With Immunotherapy and Chemotherapy for Pre-treated Patients With Small Cell Lung Cancer and Liver Metastases
NCT07699952
First-line Therapy With EGFR-TKI Combined With Trastuzumab Rezetecan for Advanced NSCLC Harboring EGFR Mutations Concomitant With HER2 Alterations
NCT07767630
An Exploratory Proof-of-Concept (POC) Study Evaluating the Safety, Tolerability, and Preliminary Efficacy of Fractionated Dosing of [211At]MABG in Patients With Relapsed or Refractory Neuroblastoma (Including a Run-in Phase)
100 项与 四川大学 相关的临床结果
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2027-01-01BIOMATERIALS
PTGFRN- and IL-4-overexpressing exosome-functionalized Janus fibrous scaffolds for enhanced heterogeneous tissue regeneration
Article
作者: Li, Jidong ; Luo, Fei ; Jin, Shue ; Zhou, Zongke
Bone defects caused by trauma, infection, or tumor removal are often combined with soft tissue injury. This creates a major clinical problem because there are no effective methods to repair both hard and soft tissues at the same time. This study presents a strategy that combines physical and biological signals based on materiobiology and immune-guided regeneration. A Janus electrospun nanofibrous scaffold loaded with immunomodulatory exosomes (ExoPTGFRN/IL-4) was designed and fabricated. The scaffold has different surface structures and mechanical properties on each side, and it can regulate immune responses needed for both bone and muscle repair. Exosomes derived from macrophages and modified with PTGFRN and IL-4 have two main roles: targeting and reprogramming of macrophages. Evaluation of the foreign body response showed that the scaffold did not cause long-term inflammation or systemic toxicity. It also regulated fibrosis, angiogenesis, and macrophage polarization. In vitro experiments and in vivo models, including muscle injury, calvarial bone defect, and mandibular defect models, showed that ExoPTGFRN/IL-4 promoted myogenic and osteogenic differentiation while suppressing osteoclastogenesis. This led to effective soft tissue repair and bone regeneration. The ExoPTGFRN/IL-4-functionalized scaffold (PHA-ExoPTGFRN/IL-4) provides a new approach for repairing heterogeneous tissues and shows strong potential application in orthopedics and maxillofacial surgery.
2027-01-01BIOMATERIALS
Lipo-protein deposition strategy towards smart microspheres with bacterial toxin triggered “adsorption-pore formation-immune regulation” cascade reaction for sepsis treatment
Article
作者: Song, Xin ; Wang, Yilin ; Xiao, Yujie ; Feng, Yuhui ; Xiang, Hongyu ; Deng, Ningyue ; Chen, Shifan ; Ling, Ziyue ; Zhao, Changsheng ; Wang, Wenjie ; Bao, Jianxu ; Liu, Xianda ; Zhao, Weifeng ; Yang, Xijing
Sepsis induced by Gram-positive bacteria causes immune disorder and multi-organ damage driven by pore-forming toxins (PFTs), which directly form pores on host cell membrane and exacerbate cell damage. Traditional drug therapy cannot remove the existing bacterial toxins, and exacerbate inflammatory storm by increasing toxin release during bacterial lysis. Meanwhile, current materials for toxin clearance lack the capability to regulate the microenvironment and pose systemic retention risks. This study proposes smart microspheres with bacterial toxin triggered "adsorption-pore formation-immune regulation" cascade reaction. The liposomes with high affinity for α-toxin (KD = 5.355 × 10-8 M) are immobilized onto polyether sulfone (PES) microspheres through a "lipo-protein deposition" strategy to prepare PES-L-Lipo-RL microspheres for extracorporeal hemoperfusion. Toxin adsorption triggers drug release by the forming pores in liposomes, inhibiting bacterial proliferation and regulating immune microenvironment (CD86-positive macrophages reduce from 23.9% to 7.6%). Notably, the expressions of virulence genes (hla, agrA) are downregulated, reducing toxin production at the source. In a rabbit sepsis model, PES-L-Lipo-RL microspheres reduce bacterial load (antibacterial rate achieves over 99% within 1 h), alleviate cytokines release, avoid multi-organ damage, and remarkably increase 28-day survival rate to 100%. The smart cascade reaction integrating toxin adsorption and immune regulation provides an effective and safe approach for sepsis therapy.
2027-01-01BIOMATERIALS
Self-organizing bioceramic granules with wave-dissipating architectures for bone void filling
Article
作者: Cao, Zhiwei ; Shang, Siyuan ; Xing, Zhengyi ; Liu, Zhanhong ; Chen, Siyu ; Ambrosio, Luigi ; Yang, Xiao ; Zeng, Yi ; Liu, Puxin ; Zhu, Xiangdong ; Zhang, Xingdong ; Raucci, Maria Grazia ; Dong, Zihao ; Tan, Wen
Granular bone substitutes readily adapt to irregular defects but lack initial stability, often resulting in granule migration and clinical complications. Inspired by the structural stability of wave-dissipating concrete blocks, which protect breakwaters from wave impact, we fabricated wave-dissipating bioceramic granules using digital light processing-based 3D printing and evaluated their potential for bone repair. Of six wave-dissipating designs, Tetrapod, Dolos, and Hexaleg were demonstrated to self-organize into the architectures featuring optimal intergranular space for bone ingrowth and minimized granule loss under dynamic conditions. For the repair of unhealed femoral defects, however, the Hexaleg implantation exhibited loose defect filling and impaired bone remodeling, despite an individual Hexaleg showing osteogenic differentiation potential in vitro attributed to its inherent macropores. In contrast, the Tetrapod and Dolos implantations achieved full and stable defect filling, supporting effective blood circulation around the defects, as well as high-quality new bone formation and host bone maintenance. These results suggest that the architecture self-organized by granule packing plays a dominant role in bone regeneration, outweighing the effects of individual granule characteristics. Overall, this work presents Tetrapod and Dolos as novel and promising bone void fillers that leverage the structural stability of wave-dissipating concepts while providing architectural cues for osteogenesis.
2026-09-19
100 项与 四川大学 相关的药物交易
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100 项与 四川大学 相关的转化医学
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管线布局
2026年09月20日管线快照
管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期
药物发现
39
226
临床前
临床1期
11
3
临床2期
临床3期
2
1
批准上市
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48
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