Objective To improve the success rate of research and development( R& D) of chems. Methods The risk factors in the pharmaceutical research in chems. were summarized through literature research method, survey research, and the risk management theory, and the countermeasures were put forward. Results The risk factors leading to the failure of pharmaceutical research in chems. included technol., production and management risks, and corresponding countermeasures were put forward for the above risks. In view of the technol. risks, control was carried out from team building, introducing top experts in this industry, strengthening tech. training and giving full play to the third-party advantage of outsourcing. In view of production risks, control was carried out from the informal survey of production equipment and project budget, ensuring that the design of the production workshop could meet the requirements of the Good Manufacturing Practice( GMP) for drugs, entrusting a third-party production company with production qualification to produce, selecting class-A active pharmaceutical ingredients and excipients, etc. In view of management risks, control was carried out from formulating the training plan and management system to improve the quality of pharmaceutical research, strengthening the communication and coordination between R & D and production personnel, and predicting the progress of laboratory research and production scale-up research. Conclusion The pharmaceutical research team of chems. should pay attention to the risk factors in the research process and take necessary risk management measures to avoid the risks in the process of pharmaceutical research in chems.