Medical and technological advancements allow increasingly complex invasive procedures to be performed on hospitalized patients, improving their survival rates and prognosis. However, these interventions impact physical, emotional, and psychological health. In this scenario, post-hospitalization syndrome (PHS) emerges as a concerning phenomenon characterized by functional, emotional, and social decline after discharge. Invasive procedures such as surgeries or prolonged use of catheters not only compromise physical integrity but also contribute to disorders like anxiety, depression, and post-traumatic stress. In fact, between 20% and 30% of patients admitted to the Intensive Care Unit (ICU) develop symptoms compatible with post-traumatic stress disorder. This underscores the need for a comprehensive approach focused on psychological and social well-being during and after the hospital stay. Despite humanization initiatives, few hospitals successfully implement them due to a lack of objective evaluations and clinical recommendations that justify their necessity.
In this regard, venous catheterization (VC) is the most prevalent invasive procedure. The pain, anxiety, or fear caused by this technique triggers physiological and psychological alterations that can interfere with the successful insertion of the device. This stress response induces vasoconstriction, reducing the caliber of the vein, which increases technical difficulty, elevates the risk of complications, raises healthcare costs, and negatively impacts patient satisfaction.
Natural outdoor environments have been shown to reduce stress, enhancing well-being and health in the general population. In this sense, the use of immersive virtual reality (IVR) to achieve immersion in virtual nature could help not only by diverting attention away from the painful or anxiety-inducing stimulus during invasive procedures but also by providing pleasant stimuli that could have a physiological impact.
The objective of this study is to evaluate the impact of IVR on stress and anxiety during VC using validated clinical scales, measuring the caliber of the vessel to be punctured, and determining salivary biomarkers of stress, well-being, and pain. Confirming this hypothesis will provide the evidence to integrate virtual reality into the National Health System as a standard tool for more humanized and innovative care.

开始日期2027-01-15

申办/合作机构

Consorci Mar Parc de Salut de Barcelona

[+1]

JPRN-UMIN000057764

/ Not yet recruiting临床3期IIT

A 2*2 Factorial Design Trial Investigating Catheter-Related Bloodstream Infection Prevention in Patients with Peripherally Inserted Central Catheters: Evaluation of Non-Inferiority of Olanexidine Gluconate Solution Compared to Chlorhexidine Alcohol and Superiority of Chlorhexidine-Containing Dressing Compared to Standard Dressing (Study on the Effectiveness of Olanexidine Gluconate and Chlorhexidine-Containing Dressing in Preventing Peripherally Inserted Central Catheter-Related Bloodstream Infections)

开始日期2026-07-01

申办/合作机构-

NCT07609797

/ RecruitingN/AIIT

The Effects of Sodium Fluoride and Chlorhexidine Use on Salivary IL-6 and Matrix Metalloproteinase Levels in Children With Active Caries

This study aims to compare salivary IL-6, MMP-8, MMP-9, and TIMP-1 levels between healthy children and caries-active children, and to evaluate the effects of 5% sodium fluoride (NaF) varnish and 2% chlorhexidine (CHX) used in caries prevention on these biomarkers.
The study will be conducted at Alanya Alaaddin Keykubat University, Faculty of Dentistry, Department of Pediatric Dentistry. Informed consent will be obtained from children and their parents/guardians. Investigator calibration will be performed using Cohen's kappa method prior to data collection. Sample size was calculated assuming 80% power (1-β = 0.80), α = 0.05, and Cohen's d ≈ 0.8, resulting in 20 participants per group using G*Power 3.1 software.
Study groups: Group A: 5% NaF varnish. Group B: 2% CHX + 5% NaF varnish. Group C: Standard oral hygiene education (negative control). Group D: Caries-free children (biological reference; baseline saliva sampling only).
Saliva samples will be collected at T0 (baseline), T1 (30 minutes post-application), and T2 (1 month). Unstimulated whole saliva will be collected, centrifuged at 5,000 g for 10 minutes at 4°C, and stored at -80°C. IL-6, MMP-8, MMP-9, and TIMP-1 levels will be measured using CE-marked/FDA-approved human saliva ELISA kits.

开始日期2026-05-15

申办/合作机构

Alanya Alaaddin Keykubat Üniversitesi

[+1]

100 项与葡萄糖氯己定相关的临床结果

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100 项与葡萄糖氯己定相关的转化医学

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100 项与葡萄糖氯己定相关的专利（医药）

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6,358

项与葡萄糖氯己定相关的文献（医药）

2026-10-01·Intensive and Critical Care Nursing

Effectiveness of chlorhexidine gluconate–impregnated dressings in preventing central line–associated bloodstream infection in a paediatric intensive care unit: A randomised controlled trial

Article

作者: Portero-Prados, Francisco Javier ; Pabón-Carrasco, Manuel ; Ponce-Blandón, José Antonio

OBJECTIVES:

To compare the effectiveness and dermatological safety of chlorhexidine gluconate (CHG)-impregnated dressings versus conventional transparent dressings in preventing central line-associated bloodstream infection (CLABSI) in paediatric patients admitted to a PICU.

METHODS:

A single-blind, randomised controlled trial with a 1:1 allocation ratio was conducted in a tertiary PICU. A total of 250 paediatric patients with a central venous catheter were included (125 per group). Patient characteristics, catheter-related variables, catheter dwell time and skin alterations were recorded. The primary outcome was CLABSI, defined according to CDC/NHSN criteria. Bivariate analyses and multivariable logistic regression were performed, including clinically relevant covariates related to catheter exposure, dressing type, and vaccination status. The trial was registered at ClinicalTrials.gov (NCT07175116).

RESULTS:

CLABSI incidence was significantly lower in the CHG group compared with the conventional dressing group (2.4% vs. 18.4%; p < 0.001). In multivariable analysis, CHG-impregnated dressings were independently associated with reduced CLABSI risk (OR = 0.15; 95% CI: 0.04-0.58). Longer catheter dwell time (OR = 1.13 per day; 95% CI: 1.04-1.22) and absence of complete vaccination (OR = 8.68; 95% CI: 2.48-30.47) were also associated with increased infection risk. Incomplete vaccination showed a similar trend without reaching statistical significance (OR = 6.48; 95% CI: 0.95-44.20). Skin alterations were more frequent in the CHG group (16.8% vs. 11.2%), predominantly in younger infants.

CONCLUSIONS:

CHG-impregnated dressings were associated with a significant reduction in CLABSI incidence in critically ill paediatric patients, although their use was linked to a modest increase in mild skin reactions.

IMPLICATIONS FOR CLINICAL PRACTICE:

CHG-impregnated dressings may be considered as part of a multifaceted infection prevention strategy, alongside appropriate catheter management, minimisation of catheter manipulation and proactive skin monitoring, with cautious and individualised use in infants.

2026-08-01·JOURNAL OF SURGICAL RESEARCH

Intra-Abdominal 0.05% Chlorhexidine Gluconate Lavage in Perforated Appendicitis

Article

作者: Keesari, Rohali ; Hwang, Rosa ; Dao, Duy T ; Mudreac, Andrew ; Kozlowski, Gabrielle ; Mattei, Peter

INTRODUCTION:

In August 2021, pediatric surgeons at our institution began using 0.05% chlorhexidine gluconate (CHG) solution in sterile water for intraoperative lavage during laparoscopic appendectomies. The goal of this study is to determine the efficacy of intraoperative lavage with 0.05% CHG in preventing surgical site infection (SSI) after appendectomy for pediatric perforated appendicitis.

METHODS:

The Electronic Medical Record was queried to identify patients aged <18 y who underwent laparoscopic appendectomy for perforated appendicitis between January 2018 and February 2025 at our institution. Demographics, preoperative laboratory values, and postoperative complications were compared between patients who did and did not receive 0.05% CHG lavage. Postoperative outcomes, including the rates of deep/organ-space SSI requiring a drainage procedure, inpatient readmission, return to operating room, and emergency department revisits, were compared between treatment and control groups with Firth logistic regression and inverse probability of treatment weighting.

RESULTS:

A total of 858 cases of laparoscopic appendectomy for perforated appendicitis were identified; 0.05% CHG lavage was used in 197 (23.0%). Postoperative drainage rate with and without 0.05% CHG lavage was 5.1% and 8.5%, respectively. Using Firth logistic regression and after adjustment for demographic variables and preoperative laboratory values, intraoperative 0.05% CHG lavage did not significantly impact the rate of deep/organ-space SSI requiring drainage procedure (adjusted odds ratio [OR]: 0.58, 95% confidence interval [CI: 0.29, 1.14]), inpatient readmission (OR: 1.40, 95% CI [0.77, 2.56]), return to the operating room (OR: 1.14, 95% CI [0.40, 3.29]), or emergency department revisit (OR: 1.19, 95% CI [0.71, 1.97]). Sensitivity analysis using inverse probability of treatment weighting was consistent with the primary Firth logistic regression analyses.

CONCLUSIONS:

A 0.05% CHG lavage during laparoscopic appendectomy for perforated appendicitis was associated with a low rate of deep/organ-space SSI requiring drainage (5%). However, it does not significantly alter postoperative outcomes. Prospective studies are needed to evaluate whether this solution lowers infectious complications.

2026-07-01·JOURNAL OF HOSPITAL INFECTION

Antimicrobial persistence for 10 days after antiseptic skin preparation in healthy volunteers

Article

作者: Nordby, T ; Hollingsworth, A ; Morse, D ; Bashir, M ; Hanson, T

Antiseptic agents reduce skin microbes and aid in the prevention of surgical site infections (SSIs). This report describes a study performed in 66 healthy volunteers to assess the persistent antimicrobial efficacy of a commercially available skin antiseptic composed of 2% CHG and 70% isopropyl alcohol (IPA). The solution was applied to the abdominal and inguinal (groin) regions and was allowed to dry before being assessed for immediate effect and covered with dressings. The antimicrobial persistence was examined at different time points over 10 days post-application and the reduction in skin bacterial levels (cfu/cm²) from baseline was assessed. The mean log₁₀ reduction in bacteria on the abdomen was 2.75 at 10 min, 2.03 at 7 days, and 1.53 at 10 days post-application. The mean log₁₀ reduction in skin bacteria on the groin was 3.59 at 10 min, 2.80 at 7 days, and 2.42 at 10 days post-application. The results showed that the antimicrobial effect of this skin preparation can be sustained for 10 days post-application when used on healthy volunteers. Further studies are needed to determine the antimicrobial persistence and effect on SSIs when this antiseptic agent is used preoperatively.

项与葡萄糖氯己定相关的新闻（医药）

2026-06-10

·信狐药迅

三个国产1类新药：豪森奥莱泊肽、信达IBI343和上海宝济KJ103提交上市申请|新受理（6.1-6.7）

本周药品注册受理数据，分门别类呈现，一目了然。(6.1-6.7）新药上市申请药品名称企业注册分类受理号奥莱泊肽注射液江苏豪森药业集团有限公司 1 CXHS2600084 奥莱泊肽注射液江苏豪森药业集团有限公司 1 CXHS2600082 奥莱泊肽注射液江苏豪森药业集团有限公司 1 CXHS2600080 奥莱泊肽注射液江苏豪森药业集团有限公司 1 CXHS2600083 奥莱泊肽注射液江苏豪森药业集团有限公司 1 CXHS2600081 奥莱泊肽注射液江苏豪森药业集团有限公司 1 CXHS2600079 缬沙坦左氨氯地平片江苏永安制药有限公司 2.3 CXHS2600078 IBI343 信达生物医药科技(杭州)有限公司 1 CXSS2600088 注射用KJ103 上海宝济药业股份有限公司 1 CXSS2600089 新药临床申请药品名称企业注册分类受理号 SYH2092注射液石药集团巨石生物制药有限公司 1 CXHL2600674 NH302注射液江苏恩华药业股份有限公司 1 CXHL2600673 NH130枸橼酸盐片江苏恩华药业股份有限公司 1 CXHL2600672 NH130枸橼酸盐片江苏恩华药业股份有限公司 1 CXHL2600671 NH130枸橼酸盐片江苏恩华药业股份有限公司 1 CXHL2600670 NH130枸橼酸盐片江苏恩华药业股份有限公司 1 CXHL2600669 RZ-520雾化吸入溶液宁康晓维生物制药(浙江)有限公司 1 CXHL2600675 HCXT-2001片(A) 上海瀚辰星泰医药科技有限公司 1 CXHL2600652 HCXT-2001片(A) 上海瀚辰星泰医药科技有限公司 1 CXHL2600651 HRS-3095片成都盛迪医药有限公司 1 CXHL2600656 HSK51155片海思科医药集团股份有限公司 1 CXHL2600650 HSK51155片海思科医药集团股份有限公司 1 CXHL2600648 HSK51155片海思科医药集团股份有限公司 1 CXHL2600647 HRS-3095片成都盛迪医药有限公司 1 CXHL2600655 HRS-3095片成都盛迪医药有限公司 1 CXHL2600654 HRS-3095片成都盛迪医药有限公司 1 CXHL2600653 ZL-65片成都赜灵生物医药科技股份有限公司 1 CXHL2600659 ZL-65片成都赜灵生物医药科技股份有限公司 1 CXHL2600658 ZL-65片成都赜灵生物医药科技股份有限公司 1 CXHL2600657 HSK51155片海思科医药集团股份有限公司 1 CXHL2600649 APH04935片广州一品红制药有限公司 1 CXHL2600662 APH04935片广州一品红制药有限公司 1 CXHL2600661 APH04935片广州一品红制药有限公司 1 CXHL2600660 磷酸ORIC-1327滴眼液成都华森奥睿药业有限公司 1 CXHL2600668 磷酸ORIC-1327滴眼液成都华森奥睿药业有限公司 1 CXHL2600667 磷酸ORIC-1327滴眼液成都华森奥睿药业有限公司 1 CXHL2600666 磷酸ORIC-1327滴眼液成都华森奥睿药业有限公司 1 CXHL2600665 磷酸ORIC-1327滴眼液成都华森奥睿药业有限公司 1 CXHL2600664 磷酸ORIC-1327滴眼液成都华森奥睿药业有限公司 1 CXHL2600663 DC7001A胶囊北京双鹤润创科技有限公司 1 CXHL2600645 DC7001A胶囊北京双鹤润创科技有限公司 1 CXHL2600646 DC7001A胶囊北京双鹤润创科技有限公司 1 CXHL2600644 DC7001A胶囊北京双鹤润创科技有限公司 1 CXHL2600643 伊匹乌肽散剂温州益承睛湛生物科技有限公司 1 CXHL2600642 注射用APG-1252 苏州亚盛药业有限公司 1 CXHL2600641 TRI-611片诺为泰医药科技(上海)有限公司 1 CXHL2600640 TRI-611片诺为泰医药科技(上海)有限公司 1 CXHL2600639 YZEE03冲洗液益洲海洋生物科技(山东)有限公司 2.3 CXHL2600676 六价重组诺如病毒疫苗(汉逊酵母) 华北制药金坦生物技术股份有限公司 1.1 CXSL2600598 六价重组诺如病毒疫苗(汉逊酵母) 华北制药金坦生物技术股份有限公司 1.1 CXSL2600597 LM101注射液北京联立众达医疗科技有限公司 1 CXSL2600608 SCTB41注射液神州细胞工程有限公司 1 CXSL2600607 SCTB41注射液神州细胞工程有限公司 1 CXSL2600606 注射用DXC016 杭州多禧生物科技有限公司 1 CXSL2600610 EX103注射液广州爱思迈生物医药科技有限公司 1 CXSL2600609 HY001N细胞注射液合源生物科技股份有限公司 1 CXSL2600604 注射用AK0406 上海爱科百发生物医药技术股份有限公司 1 CXSL2600596 奥妥珠单抗β注射液北京天广实生物技术股份有限公司 1 CXSL2600595 注射用HMPL-A830 和记黄埔医药(上海)有限公司 1 CXSL2600599 QLS2404注射液齐鲁制药有限公司 1 CXSL2600601 QLS2404注射液齐鲁制药有限公司 1 CXSL2600600 MG-K10人源化单抗注射液湖南麦济生物技术股份有限公司 1 CXSL2600603 VG712注射液成都维瑾柏鳌生物医药科技有限公司 1 CXSL2600592 注射用MC002 杭州麦联科生物医药有限公司 1 CXSL2600590 注射用重组抗PD1/TIM3人源化双特异抗体健信生物科技(宁波)有限公司 1 CXSL2600591 注射用LB4330 健信生物科技(宁波)有限公司 1 CXSL2600593 IBI3014 信达生物制药(苏州)有限公司 1 CXSL2600594 SHR-1179注射液广东恒瑞医药有限公司 1 CXSL2600586 GR2302注射液智翔(上海)医药科技有限公司 1 CXSL2600587 GR2302注射液(皮下注射) 智翔(上海)医药科技有限公司 1 CXSL2600588 GR2302注射液(皮下注射) 智翔(上海)医药科技有限公司 1 CXSL2600589 仿制药申请药品名称企业注册分类受理号注射用盐酸兰地洛尔朗天药业(湖北)有限公司 3 CYHS2601314 维生素K1注射液江苏润恒制药有限公司 3 CYHS2601318 洛索洛芬钠口服溶液山东丹红制药有限公司 3 CYHS2601315 注射用西维来司他钠重庆莱美药业股份有限公司 3 CYHS2601320 右酮洛芬氨丁三醇口服溶液北京远方通达医药技术有限公司 3 CYHS2601290 己酮可可碱缓释片黑龙江亿达鸿药业有限公司 3 CYHS2601283 复方匹可硫酸钠颗粒浙江金华康恩贝生物制药有限公司 3 CYHS2601269 盐酸二甲双胍缓释片(IV) 北京双鹭药业股份有限公司 3 CYHS2601267 呋塞米口服溶液联环药业(安庆)有限公司 3 CYHS2601264 盐酸曲唑酮口服溶液北京远方通达医药技术有限公司 3 CYHS2601262 硫辛酸片北京双鹭药业股份有限公司 3 CYHS2601259 呋塞米注射液江西泰吉立生物制药有限公司 3 CYHS2601301 聚普瑞锌颗粒安徽佳和药业有限公司 3 CYHS2601298 布洛芬颗粒江苏联环药业股份有限公司 3 CYHS2601260 注射用甲磺酸萘莫司他烟台东诚北方制药有限公司 3 CYHS2601294 吡拉西坦注射液许昌未来制药有限责任公司 3 CYHS2601278 碳酸氢钠血滤置换液(无钾、无钙、0.6mmol/L镁) 石家庄四药有限公司 3 CYHS2601304 碳酸氢钠血滤置换液石家庄四药有限公司 3 CYHS2601295 硫酸沙丁胺醇口服溶液北京民康百草医药科技有限公司 3 CYHS2601282 注射用盐酸兰地洛尔四川奥邦古得药业有限公司 3 CYHS2601276 盐酸氯普鲁卡因注射液福安药业集团宁波天衡制药有限公司 3 CYHS2601281 对乙酰氨基酚维生素C泡腾片南京海纳制药有限公司 3 CYHS2601286 头孢呋辛酯干混悬剂福安药业集团庆余堂制药有限公司 3 CYHS2601293 注射用西维来司他钠重庆华邦制药有限公司 3 CYHS2601279 磷酸二氢钠磷酸氢二钠颗粒伊春康尔心药业有限公司 3 CYHS2601253 氨溴特罗口服溶液江西半边天药业有限公司 3 CYHS2601258 盐酸氯普鲁卡因注射液北京紫萌医药科技有限公司 3 CYHS2601220 盐酸氯普鲁卡因注射液北京紫萌医药科技有限公司 3 CYHS2601219 右酮洛芬氨丁三醇注射液中润药业有限公司 3 CYHS2601218 普罗布考片宁夏康亚药业股份有限公司 3 CYHS2601226 中性低钙腹膜透析液(碳酸氢盐-G2.5%) 广东科泓药业有限公司 3 CYHS2601230 盐酸氯普鲁卡因注射液成都瑞尔医药科技有限公司 3 CYHS2601237 葡萄糖酸氯己定含漱液北京远方通达医药技术有限公司 3 CYHS2601233 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ω-3脂肪酸乙酯90软胶囊成都诺和晟鸿生物制药有限公司 4 CYHS2601216 注射用硫酸艾沙康唑山东鲁抗医药股份有限公司 4 CYHS2601214 达格列净片江苏欧歌制药有限公司 4 CYHS2601229 达格列净片江苏欧歌制药有限公司 4 CYHS2601228 艾拉莫德片沈阳欣瑞制药有限公司 4 CYHS2601227 甲硝唑凝胶河南大新药业有限公司 4 CYHS2601225 甲硝唑凝胶遂成药业股份有限公司 4 CYHS2601224 甲硝唑凝胶遂成药业股份有限公司 4 CYHS2601223 甲硝唑凝胶遂成药业股份有限公司 4 CYHS2601222 阿昔替尼片南京正大天晴制药有限公司 4 CYHS2601231 苯磺酸美洛加巴林片湖南一格制药有限公司 4 CYHS2601235 苯磺酸美洛加巴林片湖南一格制药有限公司 4 CYHS2601234 甲硝唑凝胶山东辰欣佛都药业股份有限公司 4 CYHS2601215 阿达帕林过氧苯甲酰凝胶乐福思健康产业股份公司 4 CYHS2601240 脂肪乳氨基酸(17)葡萄糖(11%)注射液四川太平洋药业有限责任公司 4 CYHS2601239 甲钴胺片山东司邦得制药有限公司 4 CYHS2601238 氟[18F]代雌二醇注射液北京诺核动力医药科技有限公司 3 CYHL2600069 达雷妥尤单抗注射液(皮下注射) 正大天晴药业集团南京顺欣制药有限公司 3.3 CXSL2600605 进口申请药品名称企业注册分类受理号夫曲司兰钠注射液 Alnylam Netherlands B.V. 5.1 JXHS2600058 注射用硫酸甲苯磺酸头孢德罗 Shionogi & Co., Ltd. 5.1 JXHS2600060 夫曲司兰钠注射液 Alnylam Netherlands B.V. 5.1 JXHS2600059 奥妥珠单抗注射液 Roche Pharma (Schweiz) AG 2.2 JXSS2600048 帕博利珠单抗注射液(皮下注射) Merck Sharp & Dohme B. 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2026-05-25

·Science Daily

Beet juice lowers blood pressure in older adults in just 2 weeks

Drinking nitrate-rich beetroot juice may do more than support heart health — it could actually reshape the bacteria living in the mouth in ways that help lower blood pressure in older adults. In the largest study of its kind, researchers found that older people who drank concentrated beetroot juice twice daily for two weeks experienced noticeable blood pressure reductions, while younger adults did not.A simple beetroot juice routine may help explain one of the more surprising links in healthy aging: the connection between bacteria in the mouth and blood pressure. Research from the University of Exeter found that older adults who drank nitrate rich beetroot juice twice a day for two weeks saw their blood pressure fall. The same effect did not appear in younger adults, even though beetroot juice also changed their oral microbiome. The study, published in Free Radical Biology and Medicine, is the largest of its kind to examine how dietary nitrate affects the mouth bacteria, nitric oxide biology, and blood vessel responses of younger and older adults. Why the Mouth Matters Nitrate is found naturally in many vegetables and plays an important role in the body. Beetroot is especially rich in nitrate, but it is not the only option. Spinach, arugula, fennel, celery, and kale are also good dietary sources. The key step happens before nitrate reaches the bloodstream. Certain bacteria in the mouth help convert nitrate from food into compounds that eventually support the production of nitric oxide. Nitric oxide helps blood vessels relax and function properly, which is important for healthy blood pressure regulation. When the balance of oral bacteria shifts in the wrong direction, that nitrate to nitric oxide pathway may become less efficient. The Exeter team found evidence that beetroot juice changed the oral microbiome in older adults in a way that appeared to support this pathway. A Two Week Beetroot Juice Test The trial included 39 adults under age 30 and 36 adults in their 60s and 70s, recruited through the NIHR Exeter Clinical Research Facility. It was supported by the Exeter Clinical Trials Unit and funded through a BBSRC Industrial Partnership Award. Participants completed two separate two week phases. In one phase, they drank regular doses of nitrate rich beetroot juice. In the other, they drank a placebo version of the juice with the nitrate removed. A two week "wash out" period separated the phases so the researchers could reset the conditions before testing the next drink. The team then used bacterial gene sequencing to study which microbes were present in the mouth before and after each condition. Older Adults Responded Differently Both age groups showed significant changes in the oral microbiome after drinking nitrate rich beetroot juice. However, the changes were not the same in younger and older participants. Among older adults, beetroot juice was linked to a notable drop in Prevotella, a group of mouth bacteria that the researchers described as potentially harmful in this context. At the same time, bacteria associated with health benefits, including Neisseria, became more abundant. The older group also began the study with higher average blood pressure than the younger group. After the nitrate rich beetroot juice phase, their blood pressure fell. That reduction was not seen after the placebo drink, and it was not observed in the younger adults. The Nitric Oxide Connection The results point to a possible reason beetroot juice may be especially useful later in life. Older adults tend to produce less nitric oxide as they age, and reduced nitric oxide availability can affect blood vessel function. Study author Professor Anni Vanhatalo, of the University of Exeter, said: "We know that a nitrate-rich diet has health benefits, and older people produce less of their own nitric oxide as they age. They also tend to have higher blood pressure, which can be linked to cardiovascular complications like heart attack and stroke. Encouraging older adults to consume more nitrate-rich vegetables could have significant long term health benefits. The good news is that if you don't like beetroot, there are many nitrate-rich alternatives like spinach, rocket, fennel, celery and kale." The findings suggest that beetroot juice may not act only through the nutrients it delivers. It may also work by changing the tiny ecosystem in the mouth that helps unlock those nutrients. Related Research Adds to the Picture Follow up work and related studies have continued to strengthen the idea that oral bacteria are central to how nitrate affects the body. A 2025 randomized, double blind, placebo controlled crossover study of 15 older adults with treated high blood pressure found that four weeks of nitrate rich beetroot juice selectively changed the oral microbiome, increasing Neisseria and decreasing Veillonella, while the intestinal microbiome did not significantly change. The same research program reported that nitrate intake affected nitrate metabolism but did not produce sustained improvements in blood pressure or vascular function in that treated hypertension group, showing that the response may depend on health status, medications, study design, and the bacteria present at baseline. A 2026 pilot study also highlighted the importance of the mouth in nitrate biology. It found that chlorhexidine, an antiseptic mouthwash, disrupted nitrate processing and reduced gastric nitric oxide synthesis, while dietary nitrate supplementation partly preserved microbial function and nitric oxide related signaling during antiseptic use. Other work has raised similar questions about antibacterial mouth rinses. A 2025 Scientific Reports study in rats found that a nitrate and antioxidant mouth rinse supported nitrate and nitrite reducing oral bacteria and was associated with lower blood pressure compared with chlorhexidine treatment. Because that study was conducted in animals, the findings cannot be directly applied to people, but they add to the broader evidence that oral bacteria can influence the nitrate pathway. A Potential Nutrition Strategy for Healthy Aging Co-author Professor Andy Jones, of the University of Exeter, said: "This study shows that nitrate-rich foods alter the oral microbiome in a way that could result in less inflammation, as well as a lowering of blood pressure in older people. This paves the way for larger studies to explore the influence of lifestyle factors and biological sex in how people respond to dietary nitrate supplementation." The findings do not mean beetroot juice is a replacement for medication or other proven ways to manage blood pressure. However, they do suggest that nitrate rich vegetables could be a practical addition to a heart healthy lifestyle, particularly for older adults. They also point to a more personalized future for nutrition. Two people can eat the same nitrate rich foods but respond differently, partly because their oral microbiomes may not process nitrate in the same way. What Comes Next The Exeter researchers say larger studies are needed to understand why some people respond more strongly than others. Future research may help reveal how lifestyle, sex, age, oral hygiene habits, and baseline microbiome differences shape the effects of dietary nitrate. Dr. Lee Beniston FRSB, Associate Director for Industry Partnerships and Collaborative Research and Development at BBSRC, said: "This research is a great example of how bioscience can help us better understand the complex links between diet, the microbiome and healthy aging. By uncovering how dietary nitrate affects oral bacteria and blood pressure in older adults, the study opens up new opportunities for improving vascular health through nutrition. BBSRC is proud to have supported this innovative partnership between academic researchers and industry to advance knowledge with real-world benefits." Together, the evidence points to a striking idea: one path to healthier blood vessels may begin not in the heart, but in the mouth.

临床结果

2026-05-11

·medicoswab.com

Why MEIDIKE GENE Stands Out Among Medical Consumables Manufacturers

In the rapidly evolving healthcare and diagnostic industry, choosing a reliable medical consumables manufacturer is essential for ensuring product quality, testing accuracy, and patient safety. Hospitals, laboratories, diagnostic companies, and distributors worldwide are seeking trusted suppliers that offer high-quality products, stable production capacity, and flexible OEM/ODM services. As a professional Chinese manufacturer of medical consumables, MEIDIKE GENE provides comprehensive specimen collection and laboratory consumable solutions for global customers. MEIDIKE GENE, a brand of Medico Technology Co., Ltd., specializes in the research, development, and manufacturing of medical consumables and diagnostic sampling products. With years of industry experience, advanced production facilities, and strict quality management systems, the company supplies reliable products to customers in healthcare, diagnostics, biotechnology, pharmaceutical, and laboratory industries worldwide. The company supports both OEM and ODM customization services, helping distributors, brands, laboratories, and medical institutions develop customized products and private-label solutions. MEIDIKE GENE manufactures a wide range of specimen collection swabs designed for clinical diagnostics, microbiological testing, genetic testing, and laboratory sampling. Main products include: Flocked Swabs Foam Swabs Rayon Swabs Cotton Swabs Polyester Swabs These swabs are widely used for: Nasopharyngeal sampling Oropharyngeal sampling Cervical specimen collection DNA sample collection Environmental sampling Laboratory testing To meet the growing demand for diagnostic testing and home sample collection, MEIDIKE GENE offers various specimen collection kits for different applications. Virus Transport Medium (VTM) kits are designed for safe collection, transportation, and preservation of virus specimens. Applications include: Respiratory virus testing Influenza testing COVID-19 testing Molecular diagnostics DNA collection kits provide convenient and non-invasive sample collection for genetic testing, forensic testing, and research applications. HPV collection kits are specially designed for cervical screening and HPV testing. The kits can include cervical sampling brushes, collection tubes, and preservation solutions. Saliva collection kits are suitable for: Genetic testing DNA analysis Drug testing Research applications Stool specimen collection kits are commonly used for microbiome research, gastrointestinal disease testing, and laboratory analysis. Urine collection kits provide hygienic and secure sample collection for diagnostic and laboratory testing. MEIDIKE GENE also manufactures infection prevention and skin preparation products, including: Chlorhexidine Applicators Antiseptic Swabs Alcohol Wipes These products are widely used in hospitals, clinics, surgical centers, and home healthcare environments for skin disinfection and infection control. The cervical cytology brush is designed for gynecological sampling and cervical cell collection. The ergonomic design helps improve patient comfort and sample collection efficiency, making it suitable for cervical cancer screening and HPV testing. MEIDIKE GENE provides high-quality Vacuum Blood Collection Tubes for clinical blood collection and laboratory analysis. Available tube types include: Serum Tubes EDTA Tubes Heparin Tubes Gel & Clot Activator Tubes Glucose Tubes The tubes are manufactured under strict quality standards to ensure accurate and reliable laboratory results. The company also offers various sample storage and transport solutions, including: Sample Storage Tubes Flip-Top Desiccant Vial Plastic Cryo Tube Urine Specimen Collection Cup Stool Collection Cup These products help ensure specimen integrity during transportation and storage. As an experienced medical consumables manufacturer from China, MEIDIKE GENE operates advanced production facilities and cleanroom manufacturing environments to ensure product consistency and quality. MEIDIKE GENE supports customized manufacturing solutions, including: Private Label Packaging Customized Product Design Customized Packaging Brand Logo Printing Custom Sampling Kits This makes the company an ideal partner for distributors, wholesalers, diagnostic brands, and healthcare companies. MEIDIKE GENE products are manufactured under strict international quality standards and have obtained certifications including: CE Certification FDA Certification ISO13485 Certification TGA Certification MDEL Certification MEIDIKE GENE products are exported to many countries and regions worldwide, serving hospitals, laboratories, diagnostic centers, research institutions, and medical distributors. If you are looking for a trusted medical consumables manufacturer with strong production capabilities, reliable quality, and professional OEM/ODM support, MEIDIKE GENE is your ideal partner. Visit the official website to learn more about products and customization services: www.medicoswab.com

诊断试剂

100 项与葡萄糖氯己定相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D00858	葡萄糖氯己定	A01AB03 S03AA04 S02AA09	DB00878

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
牙周炎	美国	Dexcel Pharma Technologies Ltd.	1998-05-15
感染	澳大利亚	Bridgewest Perth Pharma Pty Ltd.	1991-08-13
细菌性皮肤疾病	澳大利亚	Bridgewest Perth Pharma Pty Ltd.	1991-08-13
牙龈疾病	美国	Solventum Corp.	1986-08-13
牙龈出血	美国	Solventum Corp.	1986-08-13
牙龈炎	美国	Solventum Corp.	1986-08-13
细菌感染	美国	Mölnlycke Health Care AB	1976-09-17
消毒剂	日本	Sumitomo Pharma Co., Ltd.	1959-09-22

未上市

10 条进展最快的记录,

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
种植体周围炎	临床3期	美国	Dexcel Pharma Technologies Ltd.	2014-07-01
种植体周围炎	临床3期	德国	Dexcel Pharma Technologies Ltd.	2014-07-01
种植体周围炎	临床3期	以色列	Dexcel Pharma Technologies Ltd.	2014-07-01
种植体周围炎	临床3期	英国	Dexcel Pharma Technologies Ltd.	2014-07-01
慢性牙周炎	临床3期	以色列	Dexcel Pharma Technologies Ltd.	2010-12-01
呼吸机相关性肺炎	临床阶段不明	美国	-	2010-07-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02572791 (SHINE, CTgov)	临床4期	细菌性皮肤疾病 \| 耐甲氧西林金黄色葡萄球菌感染	835	Chlorhexidine+Mupirocin (Periodic Personal Decolonization)	鹽醖糧鬱醖壓觸獵積醖 = 觸築獵膚鑰構製襯衊願鬱製衊憲願遞蓋鹹膚繭 (獵鹹蓋醖願鏇鹹齋製蓋, 艱鏇襯艱築選憲繭膚構 ~ 餘繭構糧糧糧願願簾糧) 更多	-	2026-02-24
				Household cleaning+Chlorhexidine+Mupirocin (Integrated Personal/Household Hygiene)	鹽醖糧鬱醖壓觸獵積醖 = 鬱鏇選廠網醖鬱觸襯窪鬱製衊憲願遞蓋鹹膚繭 (獵鹹蓋醖願鏇鹹齋製蓋, 餘衊積築艱衊簾艱壓顧 ~ 醖觸醖築襯壓遞鏇簾襯) 更多
NCT05110001 (REAGIR, CTgov)	临床3期	棘阿米巴角膜炎 \| 真菌性角膜炎	330	Placebo+Chlorhexidine Gluconate+Moxifloxacin Ophthalmic+Natamycin (Standard Therapy)	積醖窪遞憲淵鬱築網齋(齋獵糧窪襯遞醖顧顧襯) = 遞膚鹹憲鏇鹹繭醖獵獵窪觸願餘齋窪衊鏇餘顧 (衊網膚網鏇糧鏇膚窪醖, 0.658) 更多	-	2026-01-30
				Chlorhexidine Gluconate+Rose Bengal+Moxifloxacin Ophthalmic+Natamycin (Cross-Linking With Rose Bengal (RB-PDT))	積醖窪遞憲淵鬱築網齋(齋獵糧窪襯遞醖顧顧襯) = 鑰窪淵鹽範遞壓憲窪齋窪觸願餘齋窪衊鏇餘顧 (衊網膚網鏇糧鏇膚窪醖, 0.675) 更多
NCT03503370 (CTgov)	临床2期	糖尿病足溃疡	175	Chlorhexidine (Chlorhexidine)	積簾醖夢夢顧構遞鏇繭 = 製範夢淵衊糧齋淵構廠憲觸憲鏇築遞顧鑰淵衊 (夢網醖鏇艱糧築膚鹹壓, 製蓋艱艱鹽繭鹹鹽齋簾 ~ 鏇觸築積願願齋膚鬱糧) 更多	-	2024-08-09
				Placebo (Placebo)	積簾醖夢夢顧構遞鏇繭 = 膚鏇艱襯壓顧觸窪鹹鬱憲觸憲鏇築遞顧鑰淵衊 (夢網醖鏇艱糧築膚鹹壓, 鑰憲鹹襯鬱構淵艱糧鑰 ~ 艱願積憲壓獵鏇淵夢淵) 更多
NCT03326726 (CTgov)	临床2期	-	30	chlorhexidine gluconate	廠襯膚繭窪夢齋淵遞選(膚鏇糧鑰艱築選選遞鏇) = 鏇鏇鬱廠願鹹衊鑰繭鹽鹽醖膚鏇襯築憲壓壓簾 (鏇顧鏇衊淵襯憲齋鏇鏇, 0.0013) 更多	-	2023-09-28
NCT03385304 (Aqueous-PREP, CTgov)	临床4期	手术伤口感染 \| 开放性骨折	1,638	povidone-iodine+chlorhexidine gluconate (10% Povidone-iodine (1% Free Iodine) in Purified Water)	襯襯選積範繭窪獵簾網 = 鹹糧獵糧艱廠鹹網膚襯膚膚衊餘範築築襯鹹艱 (構糧鬱壓鏇鑰壓餘繭選, 襯鬱積醖醖艱觸製製壓 ~ 網夢選糧襯廠齋鑰繭鹹) 更多	-	2023-03-31
				povidone-iodine+chlorhexidine gluconate (4% Chlorhexidine Gluconate (CHG) in Purified Water)	襯襯選積範繭窪獵簾網 = 鹹艱範鏇繭夢簾襯範鬱膚膚衊餘範築築襯鹹艱 (構糧鬱壓鏇鑰壓餘繭選, 衊製淵顧糧夢醖鬱壓夢 ~ 艱選構夢選構構構醖餘) 更多
NCT03423147 (PRACTICAL, CTgov)	临床2期	手术伤口感染 \| 交叉感染	319	Chlorhexidine gluconate (Chlorhexidine Gluconate Vaginal Scrub and Cloth)	醖憲憲鏇淵憲構構鹽襯 = 夢餘醖遞壓襯鏇顧襯艱簾網糧鹽網範壓選築鏇 (齋鹽夢廠積網觸鹹構餘, 壓遞淵簾獵築簾齋鹹範 ~ 製鏇艱夢簾鬱醖顧壓網) 更多	-	2023-03-23
				2% chlorhexidine gluconate cloth (Standard Treatment)	醖憲憲鏇淵憲構構鹽襯 = 鏇蓋顧餘齋醖製廠獵積簾網糧鹽網範壓選築鏇 (齋鹽夢廠積網觸鹹構餘, 憲鏇範獵夢齋築構願積 ~ 繭鬱淵繭醖鬱獵艱糧範) 更多
NCT03883828 (ASCO2022) 人工标引	临床2/3期	放射性皮炎	76	mupirocin+Chlorhexidine gluconate	餘廠鬱膚淵憲遞製齋壓(觸齋築膚衊餘廠廠鑰憲) = 願糧壓遞衊鏇築範鏇築簾願鏇遞鏇窪膚齋繭顧 (壓簾憲淵獵築觸繭遞網 ) 更多	积极	2022-06-08
				standard of care	餘廠鬱膚淵憲遞製齋壓(觸齋築膚衊餘廠廠鑰憲) = 膚艱衊齋艱襯鏇夢夢夢簾願鏇遞鏇窪膚齋繭顧 (壓簾憲淵獵築觸繭遞網 ) 更多
NCT04748783 (COL, CTgov)	临床2期	新型冠状病毒感染	2	Water (Sterile Water)	夢鏇遞艱簾鬱網醖糧憲(艱夢夢鹽艱範糧願夢憲) = 觸製繭壓繭憲夢遞觸窪範願簾鏇壓餘範窪醖顧 (壓網鏇艱獵憲製蓋窪夢, 壓選糧襯襯鬱襯鏇網窪 ~ 遞鑰獵簾蓋鬱築鏇衊築) 更多	-	2022-02-16
				Peroxyl (Peroxyl)	夢鏇遞艱簾鬱網醖糧憲(艱夢夢鹽艱範糧願夢憲) = 憲夢窪遞選觸衊壓衊網範願簾鏇壓餘範窪醖顧 (壓網鏇艱獵憲製蓋窪夢, 餘鏇鹽選衊獵餘範簾遞 ~ 鬱糧廠願壓齋餘願鹹繭) 更多
NCT02395614 (CTgov)	N/A	手术伤口感染 \| 乳腺癌	88	Chlorhexidine irrigation (Chlorhexidine Irrigation)	襯顧獵範鑰餘觸膚襯網(獵鑰膚觸鏇餘鏇繭築蓋) = 淵遞夢餘壓齋蓋齋觸蓋鹽襯艱觸餘艱構鹹獵鬱 (鑰壓繭鬱夢齋繭遞糧衊, 淵繭憲憲蓋範窪壓繭艱 ~ 衊齋鏇衊鹽觸選齋艱膚) 更多	-	2022-01-26
				cefazolin+bacitracin+gentamicin (Triple Antibiotic Irrigation)	襯顧獵範鑰餘觸膚襯網(獵鑰膚觸鏇餘鏇繭築蓋) = 獵壓蓋構築襯遞壓觸夢鹽襯艱觸餘艱構鹹獵鬱 (鑰壓繭鬱夢齋繭遞糧衊, 獵製齋壓艱鬱簾淵淵醖 ~ 顧齋顧鬱選獵蓋製鹽繭) 更多
NCT04373421 (CTgov)	临床4期	术后并发症	90	Chlorhexidine Gluconate+benzydamine hydrochloride (Chlorhexidine Gluconate Plus Benzydamine Hydrochloride)	鹹選艱醖選餘糧鑰築壓(積廠顧鹽壓繭憲願築築) = 餘襯積襯積襯淵衊觸鑰鑰築繭夢鬱蓋簾夢鬱壓 (衊夢窪顧範繭築鹽餘築, 21.9) 更多	-	2021-11-01
				St. John's wort oil (St. John's Wort Oil)	鹹選艱醖選餘糧鑰築壓(積廠顧鹽壓繭憲願築築) = 積齋顧積餘鹽襯膚壓構鑰築繭夢鬱蓋簾夢鬱壓 (衊夢窪顧範繭築鹽餘築, 24.1) 更多