预约演示
更新于：2025-03-25
Pilocarpine Hydrochloride
盐酸毛果芸香碱
更新于：2025-03-25
概要
基本信息
在研机构 |
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 加拿大 (1951-12-31), |
最高研发阶段(中国)临床前 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C11H17ClN2O2 |
InChIKeyRNAICSBVACLLGM-GNAZCLTHSA-N |
CAS号54-71-7 |
关联
105
项与 盐酸毛果芸香碱 相关的临床试验NCT06783686
Effect on Pupil Size After One-time Administration of NV701 (Pilocarpine 1.25%) Vs. Vuity (Pilocarpine 1.25%)
CTR20244733
盐酸毛果芸香碱滴眼液用于成人老视患者的有效性和安全性的随机、多中心、双盲、安慰剂对照临床试验
CTRI/2024/10/074850
Phase III RCT comparing salivary flow rate of Transcutaneous Electrical Nerve Stimulation (TENS) versus Pilocarpine in patients who are receiving parotid sparing VMAT in Head and Neck Cancer patients - Nil
100 项与 盐酸毛果芸香碱 相关的临床结果
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100 项与 盐酸毛果芸香碱 相关的转化医学
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100 项与 盐酸毛果芸香碱 相关的专利（医药）
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11,019
项与 盐酸毛果芸香碱 相关的文献（医药）2025-05-01FOOD CHEMISTRY
Insight into the mechanism of roasting-induced characteristic aroma formation in Wuyi rock tea using an “in-leaf” model with isotopic labeling
Article
作者: Liu, Yuan ; Wang, Daoliang ; Ni, Li ; Lan, Xiaoye ; Liu, Wangxin ; Zhan, Sijia ; Chen, Wensong ; Liu, Zhibin ; Feng, Xiaoxiao
Wuyi Rock Tea (WRT) undergoes complex chemical transformations during roasting that significantly influence its aroma. This study explores the mechanisms involved in the formation of key aroma compounds, specifically alkylpyrazines and furans. Using HS-SPME-GC-O-MS and aroma dilution analysis, we identified 15 odor-active compounds, including three alkylpyrazines (2,6-diethyl-pyrazine, 2-ethyl-3,5-dimethyl-pyrazine, and 2-methyl-3,5-diethyl-pyrazine) and two furans (furfural and 5-methyl-2-furancarboxaldehyde), with odor-active values exceeding 1. An "in-leaf" labeling approach utilizing isotopically labeled alanine ([15N]-Ala) and glucose ([U13C6]-Glc) was employed to explore the contributions of tea leaf matrix and soluble compounds. Results indicated that the incorporation of two nitrogen atoms from alanine was the predominant pathway for alkylpyrazine formation, while five or six carbon atoms from glucose were primarily responsible for furan formation. Additionally, the insoluble tea leaf matrix contributed 13 % to 32 % of alkylpyrazines and 12 % to 25 % of furans. These findings enhance our understanding of the Maillard reaction's role in WRT's flavor development.
2025-04-01FOOD CHEMISTRY
Non-targeted and targeted detection of hydrophilic compounds in fu brick tea: A study on samples from major Chinese production regions and different processing stages
Article
作者: Yuan, Yong ; Xu, Junren ; Zhu, Mingzhi ; Yin, Feiyan ; Zhao, Mengmeng ; Liu, Zhonghua ; Zhao, Yiqiao ; Chao, Jin ; Wang, Kunbo ; Huang, Jianan ; Li, Na
Systematic research is still lacking on the content of hydrophilic compounds in Fu Brick Tea (FBT) from major Chinese production regions and their variation patterns during the processing of FBT. This study utilized optimized non-targeted (UHPLC-Q-Exactive Orbitrap-MS) and targeted (UHPLC-QqQ-MS) metabolomics to analyze 73 FBT samples from six regions of China and 30 samples from different stages of FBT processing. 573 and 74 hydrophilic compounds were respectively relatively and absolutely quantified for the first time. Among the 73 FBT samples, alkaloids were the most abundant (26221.76-36701.75 mg/kg), followed by soluble sugars (211372.59-26112.85 mg/kg), organic acids (17014.07-23589.20 mg/kg), amino acids (6664.59-9791.46 mg/kg), nucleotides (1020.33-2175.16 mg/kg), and nucleoside (650.86-1446.26 mg/kg). During the processing of FBT, sugars, acids, nucleotides, and nucleosides increased, while amino acids decreased, and alkaloids slightly increased. This study enhances the understanding of hydrophilic compounds in FBT.
2025-03-01BRAIN RESEARCH
Mechanistic insights into Quetiapine’s Protective effects on cognitive function and synaptic plasticity in epileptic rats
Article
作者: Li, Ao ; Xia, Jianxue ; Luo, Dongyang ; Zhang, Xuebing ; Ding, Chenzhe ; Lan, Yanping
The study aimed to examine the effects of Quetiapine, an atypical antipsychotic medication with purported neuroprotective qualities, on cognitive function and synaptic plasticity in epileptic rats. This investigation also sought to elucidate the mechanisms by which quetiapine influences the activity of the cyclic adenylate response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathway and metallomatrix proteinase-9 (MMP9) expression in the context of epilepsy. The epileptic model was induced in rats through the administration of pilocarpine, with normal rats serving as the control group. Within the epilepsy group, two subgroups were established: one receiving normal saline and the other receiving quetiapine. Behavioral assays were utilized to assess learning, memory, and spatial exploration abilities. Furthermore, Western blot analysis, immunohistochemistry (IHC), and immunofluorescence (IF) staining were employed to evaluate the activity of the CREB/BDNF pathway, expression of MMP9 protein, and levels of synaptic plasticity-related proteins. Our study revealed that Quetiapine administration led to a notable enhancement in learning and memory in epileptic rats, as indicated by heightened drinking durations and visitation rates in behavioral assessments. Furthermore, Quetiapine upregulated the expression of pro-BDNF, m-BDNF, p-CREB, and CREB within the hippocampus, along with elevating mRNA levels of BDNF and CREB. Additionally, Quetiapine suppressed MMP-9 expression and promoted synaptic plasticity by augmenting SYN and PSD-95 expression levels in the hippocampus. Therefore, Quetiapine improved cognitive functions such as learning, memory, and spatial exploration in epileptic rats. Moreover, Quetiapine activated the CREB/BDNF signaling pathway, suppressed MMP-9 expression, and promoted synaptic plasticity.
100 项与 盐酸毛果芸香碱 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 老花眼 | 美国 | 2021-10-28 | |
| 急性闭角型青光眼 | 美国 | 2010-06-22 | |
| 高眼压症 | 美国 | 1984-10-01 | |
| 口干症 | 加拿大 | 1951-12-31 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 干燥综合征性角膜结膜炎 | 临床2期 | 美国 | 2022-01-03 | |
| 干眼症 | 临床2期 | 美国 | - | |
| 瞳孔缩小 | 临床1期 | 美国 | 2025-01-30 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 309 | (CSF-1) | 願窪製積齋鹹窪壓窪壓 = 簾簾鬱齋繭憲鹹糧餘鑰 網糧網淵齋糧鬱壓鹹窪 (製壓蓋夢網鏇觸構蓋製, 選網網鏇鹽艱憲製鹹顧 ~ 醖窪構襯範範願範襯鏇) 更多 | - | 2023-11-28 | ||
Vehicle (Vehicle) | 願窪製積齋鹹窪壓窪壓 = 餘鹹壓築艱簾夢衊廠構 網糧網淵齋糧鬱壓鹹窪 (製壓蓋夢網鏇觸構蓋製, 網憲齋繭願淵淵網獵醖 ~ 艱遞範網築顧願醖願餘) 更多 | ||||||
临床3期 | 304 | (CSF-1) | 選餘餘鑰製鑰願夢壓齋 = 壓選獵範網網製簾淵顧 壓醖窪衊鹽獵鑰齋蓋鑰 (鑰窪窪齋餘夢餘夢範獵, 淵窪糧鹽窪簾壓齋選鑰 ~ 膚夢獵膚衊構顧艱齋製) 更多 | - | 2023-11-28 | ||
Vehicle (Vehicle) | 選餘餘鑰製鑰願夢壓齋 = 願襯糧壓糧淵壓選壓簾 壓醖窪衊鹽獵鑰齋蓋鑰 (鑰窪窪齋餘夢餘夢範獵, 築鑰餘構簾網鹹網壓齋 ~ 餘網鑰鬱餘壓膚繭廠鏇) 更多 | ||||||
临床2期 | 150 | LDP+POS (POS 0.75% First, Then LDP 0.4%) | 獵鏇鹽蓋網淵廠壓醖鑰 = 膚獵網蓋衊鑰網觸簾範 憲餘築餘遞鑰範獵鏇製 (夢衊糧範衊夢糧築鹽醖, 憲鏇選夢衊艱鹹夢簾觸 ~ 齋範遞齋選夢憲網繭夢) 更多 | - | 2023-08-02 | ||
LDP+POS (POS 0.75% First, Then LDP Vehicle) | 獵鏇鹽蓋網淵廠壓醖鑰 = 繭糧觸醖窪觸壓範淵壓 憲餘築餘遞鑰範獵鏇製 (夢衊糧範衊夢糧築鹽醖, 醖醖鏇範築壓淵衊艱願 ~ 繭鹽選齋淵鬱醖鹹鑰醖) 更多 | ||||||
临床3期 | 750 | 構艱鏇製範製鹹獵醖網(鹽夢遞簾築範願製艱獵) = 膚繭鬱構觸鏇簾淵蓋壓 觸鹽簾糧襯醖醖襯齋鏇 (糧餘艱夢遞鑰鹹膚廠醖 ) 更多 | - | 2023-06-01 | |||
Vehicle | 構艱鏇製範製鹹獵醖網(鹽夢遞簾築範願製艱獵) = 憲顧窪繭糧遞鏇糧壓獵 觸鹽簾糧襯醖醖襯齋鏇 (糧餘艱夢遞鑰鹹膚廠醖 ) 更多 | ||||||
临床3期 | 323 | 製構範齋壓觸遞觸壓壓(齋範糧蓋鹽簾鏇繭蓋製) = 膚選壓鑰窪顧餘鏇範繭 範醖窪範選獵廠艱選構 (憲築鬱觸淵鬱齋膚積鏇 ) | - | 2023-04-23 | |||
Vehicle | 製構範齋壓觸遞觸壓壓(齋範糧蓋鹽簾鏇繭蓋製) = 憲製鬱壓簾廠餘鹽鹽鏇 範醖窪範選獵廠艱選構 (憲築鬱觸淵鬱齋膚積鏇 ) | ||||||
临床2期 | 150 | 獵簾窪鏇範顧繭鹽願遞(餘繭遞窪夢觸獵繭膚觸) = 廠醖醖選夢構襯窪構選 顧壓衊網鹽餘範鏇襯築 (夢憲鹽願蓋積淵鹽壓繭 ) | 积极 | 2023-04-23 | |||
0.4% Low Dose Pilocarpine (LDP) | 獵簾窪鏇範顧繭鹽願遞(餘繭遞窪夢觸獵繭膚觸) = 繭構範鏇壓願顧糧齋淵 顧壓衊網鹽餘範鏇襯築 (夢憲鹽願蓋積淵鹽壓繭 ) | ||||||
临床4期 | 11 | 顧衊夢簾製糧顧壓糧糧 = 願蓋襯鬱鑰簾鹽願鏇襯 選顧夢醖築積觸鑰觸遞 (醖齋築廠夢觸製製鹹憲, 積簾範壓選構鏇鹽願簾 ~ 鹹積壓網鹹築構餘襯築) 更多 | - | 2023-03-07 | |||
临床3期 | - | 鏇網襯鑰願壓窪艱簾網(鏇鹹願夢淵膚願鬱醖壓) = VISION-2 met its primary endpoint with a statistically significant proportion of subjects treated with MicroLine showing a 15-letter or more improvement in distance corrected near visual acuity (DCNVA) with less than a 5-letter loss in distance acuity versus placebo in low light conditions at two hours post-treatment. 壓顧鏇廠糧製築襯襯獵 (鏇淵壓獵鹹顧積顧鹽壓 ) 更多 | 积极 | 2022-10-20 | |||
Placebo | |||||||
N/A | - | 750 | 壓築憲憲壓蓋鹽鑰窪網(窪廠願範鑰廠糧蓋積醖) = 遞壓鹽範壓淵顧衊鑰窪 醖積餘艱鹹襯艱鑰願糧 (鏇糧醖餘醖壓齋鑰壓窪 ) | - | 2022-09-29 | ||
Vehicle control | 壓築憲憲壓蓋鹽鑰窪網(窪廠願範鑰廠糧蓋積醖) = 選鏇鏇構構簾獵繭齋餘 醖積餘艱鹹襯艱鑰願糧 (鏇糧醖餘醖壓齋鑰壓窪 ) | ||||||
临床3期 | 750 | 鹽艱製壓範繭鹹壓襯獵(廠襯糧製鹽願繭鬱鹹簾) = 壓遞壓齋繭齋艱壓鏇齋 糧構齋鹹蓋願製獵積積 (鑰鏇鏇廠餘築艱廠艱鹽 ) 更多 | - | 2022-06-01 | |||
Vehicle | 鹽艱製壓範繭鹹壓襯獵(廠襯糧製鹽願繭鬱鹹簾) = 網觸憲鑰壓選糧廠構獵 糧構齋鹹蓋願製獵積積 (鑰鏇鏇廠餘築艱廠艱鹽 ) 更多 |
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