Uproleselan

Continued clinical progress for the vebreltinib registration-enabling program, including new data in non-CNS MET fusion tumors and non-small cell lung cancer (NSCLC) with MET amplification $25.9 million in cash and cash equivalents as of June 30, 2024; cash runway into the third quarter of 2025 FOSTER CITY, Calif., Aug. 14, 2024 (GLOBE NEWSWIRE) -- Apollomics Inc. (Nasdaq: APLM) (“Apollomics” or the “Company”), a late-stage clinical biopharmaceutical company developing multiple oncology drug candidates to address difficult-to-treat and treatment-resistant cancers, today announced financial results for the first half of 2024 ended June 30, 2024, and highlighted updates for its pipeline. “Thus far in 2024, we have announced promising preliminary results from our vebreltinib program for the treatment of various tumors with Met dysregulation. This includes new Apollomics data for the treatment of non-CNS solid tumors with Met fusions, an incremental data update for NSCLC with MET Exon 14 skipping earlier in the year and data for the treatment of NSCLC with MET Amplification shared in this announcement,” said Guo-Liang Yu, Ph.D., Chairman and Chief Executive Officer of Apollomics. “We are encouraged by these new data and remain focused on progressing the vebreltinib program to its first regulatory submission. We look forward to providing future data updates for this program.” Pipeline Update Vebreltinib (APL-101) – a highly specific Met inhibitor for the treatment of NSCLC and other solid tumors with Met dysregulation In August 2024, the Company announced data from its SPARTA Phase 2 clinical trial for 14 patients with non-CNS MET fusion solid tumors, where a 43% objective response rate (ORR) was achieved by RECIST v1.1 criteria. This includes six confirmed responses out of 14 evaluable patients: one complete response in second-line metastatic NSCLC and five partial responses (three patients with NSCLC, one patient with pancreatic cancer, and one patient with intrahepatic bile duct cancer). Alongside the Avistone data for vebreltinib in the treatment of glioblastoma with PTPRZ1 MET fusions, vebreltinib has now demonstrated activity in a variety of tumors with MET fusions.Apollomics has also recently completed an analysis of 38 patients in the SPARTA MET amplification cohorts. Testing method discordance (determination of MET amplification by status sequencing of blood, sequencing of tumor biopsies, and/or fluorescent in-situ hybridization (FISH), as well as the use of local versus central laboratory testing), has complicated the analysis. Of the patients with the highest MET gene copy number (GCN) as determined by central sequencing, an ORR of 30% (3/10) was achieved, as compared to 13% (5/38) in the overall dataset. Going forward, Apollomics will only enroll NSCLC patients with MET amplification confirmed by central FISH testing. Apollomics believes that MET GCN ≥10 by sequencing may be comparable to GCN ≥6 by central FISH testing, which is the criteria to define MET amplification used in previous clinical trials of other MET inhibitors.In March 2024, Apollomics announced an updated efficacy analysis by gene copy number (GCN) subgroup in the treatment of NSCLC patients with Met Exon 14 skipping mutations. The data show vebreltinib activity similar to previously announced. In the absence of overlapping c-Met amplification (GCN<4), in a pooled analysis of patients from SPARTA and KUNPENG an ORR of 67% was achieved (n=86). Uproleselan (APL-106) – an E-selectin inhibitor as an adjunct to chemotherapy in acute myeloid leukemia (AML) treatment In May 2024, GlycoMimetics, our licensor of uproleselan in China, announced negative results from its pivotal Phase 3 study of uproleselan in relapsed or refractory acute myeloid leukemia. Apollomics is conducting a Phase 3 bridging study of uproleselan in China for the same indication. As positive results from the GlycoMimetics global study were likely necessary for approval of uproleselan in China for this indication, the Company has decided to close this study early and unblind after treatment for all patients is completed. As a result of these negative Phase 3 results from GlycoMimetics, the Company determined the recoverable amount was lower than the carrying value of the intangible asset and recorded an impairment loss of $10.0 million to write down the full value of our intangible asset for this program. Business Highlights Focus on vebreltinib: In July 2024, Apollomics announced a strategic prioritization for the treatment of NSCLC patients with Met Amplification. By focusing on the patient population with the greatest unmet medical need that can be addressed by MET inhibition with vebreltinib, Apollomics intends to apply its resources in the most efficient manner to generate additional clinical data for support of regulatory submissions. Leadership team changes: As previously announced, as a result of the updated strategic focus, and aligned with the Company’s resource needs going forward, Sanjeev Redkar, Ph.D., Company co-founder and former President, and Peony Yu, M.D., former Chief Medical Officer, have departed their previous roles and are expected to transition to consulting roles in August. Dr. Redkar will remain on the Board of Directors. Raised $5.8 million: In May 2024, the Company raised $5.8 million in a private placement in public equity (PIPE) financing, before transaction expenses. First Half 2024 Financial Results Cash, cash equivalents, bank deposits and money market funds as of June 30, 2024 were $25.9 million, compared to $37.8 million as of December 31, 2023. Based on current projections, the Company believes its cash position is sufficient to fund planned operations into the third quarter of 2025. Research and development (R&D) expenses were $16.9 million, including share-based compensation of $3.7 million, for the first half of 2024, compared to $16.5 million, including share-based compensation of $2.8 million, for the first half of 2023. General and administrative (G&A) expenses were $10.2 million, including share-based compensation of $4.5 million, for the first half of 2024, compared to $9.7 million, including share-based compensation of $2.4 million, for the first half of 2023. Net loss for the first half of 2024 was $(35.2) million, or $(0.38) per basic and diluted share, compared with a net loss of $(150.7) million, or $(2.55) per basic and diluted share, for the first half of 2023. Net loss for the first half of 2024 includes an impairment loss of $10.0 million to write down the full value of the uproleselan intangible asset. Net loss for the first half of 2023 includes a non-cash expense for change in fair value of convertible preferred shares of $76.4 million and expenses related to capital markets activities of $45.5 million. About Apollomics Inc. Apollomics Inc. is an innovative clinical-stage biopharmaceutical company focused on the discovery and development of oncology therapies with the potential to be combined with other treatment options to harness the immune system and target specific molecular pathways to inhibit cancer. Apollomics’ lead programs include its core product, vebreltinib (APL-101), a potent, selective c-Met inhibitor for the treatment of non-small cell lung cancer and other advanced tumors with c-Met alterations, which is currently in a Phase 2 multicohort clinical trial in the United States, and uproleselan (APL-106), a specific E-selectin antagonist that has the potential to be used adjunctively with standard chemotherapy to treat acute myeloid leukemia and other hematologic cancers, which is currently in Phase 1 and Phase 3 clinical trials in China. For more information, please visit www.apollomicsinc.com. Cautionary Statement Regarding Forward-Looking Statements This press release includes statements that constitute “forward-looking statements” within the meaning of the federal securities laws, including Section 27A of the Securities Act of 1933, as amended (the “Securities Act”), and Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”). All statements, other than statements of present or historical fact included in this press release, regarding the Company’s strategy, prospects, plans and objectives are forward-looking statements. When used in this press release, the words “could,” “should,” “will,” “may,” “believe,” “anticipate,” “intend,” “estimate,” “expect,” “project,” the negative of such terms and other similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain such identifying words. These forward-looking statements are based on management’s current expectations and assumptions about future events and are based on currently available information as to the outcome and timing of future events. Apollomics cautions you that these forward-looking statements are subject to numerous risks and uncertainties, most of which are difficult to predict and many of which are beyond the control of Apollomics. In addition, Apollomics cautions you that the forward-looking statements contained in this press release are subject to unknown risks, uncertainties and other factors, including: (i) the impact of any current or new government regulations in the United States and China affecting Apollomics’ operations and the continued listing of Apollomics’ securities; (ii) the inability to achieve successful clinical results or to obtain licensing of third-party intellectual property rights for future discovery and development of Apollomics’ oncology projects; (iii) the failure to commercialize product candidates and achieve market acceptance of such product candidates; (iv) the failure to protect Apollomics’ intellectual property; (v) breaches in data security; (vi) the risk that Apollomics may not be able to develop and maintain effective internal controls; (vii) unfavorable changes to the regulatory environment; and (viii) those risks and uncertainties discussed in the Annual Report on Form 20-F for the year ended December 31, 2023, filed by Apollomics Inc. with the U.S. Securities and Exchange Commission (“SEC”) under the heading “Risk Factors” and the other documents filed, or to be filed, by the Company with the SEC. Additional information concerning these and other factors that may impact the operations and projections discussed herein can be found in the reports that Apollomics has filed and will file from time to time with the SEC. These SEC filings are available publicly on the SEC’s website at www.sec.gov. Forward-looking statements speak only as of the date made by the Company. Apollomics undertakes no obligation to update publicly any of its forward-looking statements to reflect actual results, new information or future events, changes in assumptions or changes in other factors affecting forward-looking statements, except to the extent required by applicable law. Investor Contact: Eric Ribner LifeSci Advisors, LLC (646) 751-4363 eric@lifesciadvisors.com APOLLOMICS INC.CONDENSED CONSOLIDATED INTERIM STATEMENTS OF FINANCIAL POSITION(All amounts in thousands of $) As of June 30, 2024(Unaudited) As of December 31, 2023 Non-current assets Plant and equipment, net$124 $161 Right-of-use assets 1,177 425 Intangible assets, net 4,747 14,757 Rental deposits 113 119 Total non-current assets 6,161 15,462 Current assets Deposits, prepayments and deferred expenses 2,483 2,108 Financial assets at fair value through profit and loss (“FVTPL”) — 5,761 Cash and cash equivalents 25,929 32,056 Total current assets 28,412 39,925 Total assets 34,573 55,387 Current liabilities Other payables and accruals 8,877 9,162 Short term bank loans 3,508 4,236 Lease liabilities, current portion 264 158 Total current liabilities 12,649 13,556 Net current assets 15,763 26,369 Total assets less current liabilities 21,924 41,831 Non-current liabilities Lease liabilities, non-current portion 951 267 Warrant liabilities at FVTPL 166 330 Total non-current liabilities 1,117 597 Net assets 20,807 41,234 Equity Share capital 11 9 Share premium 666,521 661,474 Reserves 36,446 26,716 Accumulated losses (682,171) (646,965) Total equity$20,807 $41,234 APOLLOMICS INC.CONDENSED CONSOLIDATED INTERIM STATEMENTS OF LOSS ANDCOMPREHENSIVE LOSS (UNAUDITED)(All amounts in thousands of $, except for per share data) Six Months Ended June 30, 2024 2023 Other income$1,737 $401 Foreign exchange losses (2) (2,104) Fair value change of financial assets at FVTPL 198 460 Fair value change of financial liabilities at FVTPL 164 676 Fair value change of convertible preferred shares — (76,430) Research and development expenses (16,926) (16,518) Administrative expenses (10,153) (9,652) Impairment of an intangible asset (10,000) — Finance costs (134) (60) Other expense (90) (47,457) Loss before taxation (35,206) (150,684) Income tax expenses — (10) Loss and total comprehensive loss for the period, net of taxation, attributable to owners of the Company$(35,206) $(150,694) Loss per share Basic loss per common share$(0.38) $(2.55) Diluted loss per common share$(0.38) $(2.55) Weighted average number of common shares outstanding – Basicand Diluted 93,740 59,000

Today, a brief rundown of news from AbbVie and AstraZeneca as well as updates from Glycomimetics, Cue Biopharma and Confo Therapeutics that you may have missed.AbbVie on Thursday reported second quarter results indicating it is weathering growing biosimilar competition& to its flagship autoimmune disease drug Humira. According to analysts with the investment bank Piper Sandler, the companys immunology business beat handily consensus revenue estimates, as two of its other drugs, Skyrizi and Rinvoq, generated more than $4 billion combined. Humira sales, at about $2.8 billion, also surpassed expectations. We think investor concerns have subsided, wrote analyst Christopher Raymond, noting that it appears Skyrizi and Rinvoq will more than make up for Humiras loss of patent exclusivity. AbbVie shares climbed 3%. Ben FidlerA Food and Drug Administration advisory panel appeared open to the agency approving a regimen of AstraZenecas immunotherapy Imfinzi that begins before surgery to remove a type of lung tumor and continues afterwards. The positive view came despite concerns from the FDA about over-treatment and difficult to decipher which part of the regimen is more beneficial. Still, FDA panelists unanimously voted Thursday to change trial protocols in the so-called perioperative setting in lung cancer going forward, meaning future clearances will require additional monetary and time investment, wrote Leerink Partners analyst Daina Graybosch. Drugmakers, as a result, will likely be more reluctant to test therapies in earlier settings, and when they do, shy away from a perioperative approach even if its whats best for patients, she wrote. Ben FidlerBelgian biotech startup Confo Therapeutics announced Friday it raised 60 million euros in a Series B financing that will help it bring two drug prospects into clinical trials. Confo is one of a number of companies developing antibodies targeting proteins known as GPCRs. The companys pipeline includes drugs for obesity and pain, one of which is partnered with Eli Lilly and already in early-stage testing. Its funding round was led by investment firm Ackermans & van Haaren, and involved other backers such as Perceptive Advisors and Wellington Partners. Gwendolyn WuGlycomimetics and Cue Biopharma both announced plans Thursday to restructure and cut jobs. Glycomimetics intends to lay off 80% of its workforce and begin a strategic review after learning the FDA will require an additional trial of its leukemia drug uproleselan before considering an approval. Cue, meanwhile, will reduce staff by 25% and seek partners for its cancer drug prospects so it can focus resources on autoimmune disease research. Ben FidlerNine months after selling Mirati Therapeutics to Bristol Myers Squibb, Charles Baum has reemerged as the CEO of a biotechnology startup. Baum on Thursday was named the head of Terremoto Biosciences, which is developing covalent medicines aimed at targets previously thought to be undruggable. The startup has raised $250 million since its inception, most recently a $175 million Series B round from Third Rock Ventures, Novo Holdings and a few other firms last November. Ben Fidler '