The purpose of this study is to determine how effective the drug pemigatinib is as a treatment option for advanced succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumors(GIST). This study will also assess the side effects associated with pemigatinib and evaluate its tolerability.
The name of the study drug involved in this study is:
• Pemigatinib (INCB054828)

开始日期2026-06-01

申办/合作机构

Dana-Farber Cancer Institute, Inc.

[+2]

NCT06728410

/ Recruiting临床2期IIT

A Phase II Study of Pemigatinib Plus Durvalumab (MEDI4736) in Previously Treated Advanced Intrahepatic Cholangiocarcinoma Patients With FGFR-2 Fusion or Rearrangement

This is a single arm phase II study of pemigatinib and durvalumab combination in patients with FGFR-2 fusion or rearrangement positive intrahepatic cholangiocarcinoma. Each cycle will be 3 weeks. Pemigatinib is administered at 13.5 mg orally daily 2 weeks on and 1 week off. Durvalumab is administered at 1500 mg intravenously once every 3 weeks. Subjects will require a visit with appropriate laboratory work prior to the start of each cycle. Disease assessment will occur every 9 weeks. Subjects will continue treatment until progression per RECIST 1.1, toxicity or subject/physician decision. A maximum of 24 months (about 35 cycles) of pemigatinib and durvalumab treatment from Cycle 1 Day 1 is allowed.

开始日期2026-01-27

申办/合作机构

Hoosier Cancer Research Network

[+3]

NCT06300528

/ Recruiting临床2期IIT

PERFORM: A Phase II Study of Pemigatinib in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphomas

The purpose of this clinical trial is to learn if the study drug pemigatinib is effective in treating patients with relapsed or refractory B-cell non-Hodgkin lymphomas.

开始日期2025-10-03

申办/合作机构

University of Utah

[+1]

100 项与佩米替尼相关的临床结果

登录后查看更多信息

100 项与佩米替尼相关的转化医学

登录后查看更多信息

100 项与佩米替尼相关的专利（医药）

登录后查看更多信息

259

项与佩米替尼相关的文献（医药）

2026-03-01·BMJ Open Ophthalmology

Impact of anticancer drugs on human Tenon’s fibroblast proliferation: implications for glaucoma surgery

Article

作者: Marengo, Barbara ; Montalto, Giulia ; Pronzato, Maria A ; Passalacqua, Mario ; Vernazza, Stefania ; Cutolo, Carlo Alberto ; Villa, Viviana ; Ricciarelli, Roberta ; Iester, Michele

Objective:

Elevated intraocular pressure (IOP) is a major risk factor for glaucoma and the primary target of current therapies. When IOP-lowering drugs are insufficient, surgical intervention may be required; however, conjunctival and subconjunctival scarring often limits long-term success. Although intraoperative and postoperative antimetabolite treatments help preserve surgical outcomes, they are associated with ocular side effects. This study investigated the effects of selected anticancer drugs on the proliferation of human Tenon’s fibroblasts (HTFs), key mediators of postoperative scarring.

Methods and analysis:

Primary HTFs were isolated from explants obtained during glaucoma surgery and characterised by immunofluorescence. The cytotoxic effects of candidate drugs were assessed using the MTT and LDH assays, while HTF migration and proliferation were evaluated by wound-healing assays. Additional cytotoxicity testing was performed on primary human trabecular meshwork cells (HTMCs) to assess ocular safety.

Results:

Under the experimental conditions used, HTF proliferation, rather than migration, was the main driver of wound closure. Among the drugs tested, pemigatinib and sorafenib significantly slowed wound closure. Pemigatinib showed no cytotoxicity in either HTFs or HTMCs, whereas sorafenib induced a moderate (28%) cytotoxic effect in HTMCs.

Conclusions:

Pemigatinib and sorafenib, two Food and Drug Administration-approved anticancer agents, effectively reduced HTF proliferation, with pemigatinib showing a more favourable safety profile. These findings identify selective fibroblast growth factor receptor (FGFR) inhibition as a promising strategy for modulating postoperative fibrosis and support further preclinical studies to evaluate the safety and efficacy of FGFR inhibitors as potential adjuncts in glaucoma surgery.

2026-03-01·Journal of Drugs in Dermatology

Management of Nail Toxicities From Fibroblast Growth Factor Receptor Inhibitors

Review

作者: Fan, Xiying ; Smith, Janellen ; Patel, Aneri Bhargav

BACKGROUND:

Alterations in fibroblast growth factor receptor (FGFR) signaling are present in many malignancies, including urothelial carcinoma, cholangiocarcinoma, and gastrointestinal cancers, and FGFR inhibitors (FGFRi) play an increasing role in the treatment of these malignancies. Nail toxicities, such as onycholysis, paronychia, and nail fragility are an important part of the adverse effect profile of FGFRi that remain underrecognized and poorly characterized.

METHODS:

We conducted a systematic literature review using PubMed and Google through March 2025, including case reports, trials, and retrospective studies reporting FGFRi-related nail disorders. Search terms included individual FGFRi (e.g., erdafitinib, pemigatinib, futibatinib) and nail-related adverse events. Data on incidence, severity (CTCAE v5.0), onset, management, and treatment impact were extracted. Statistical analyses included the Wilcoxon and Chi-square tests.

RESULTS:

Twenty-three studies with 1,561 patients were analyzed. Out of these, 540 patients experienced nail toxicity. Erdafitinib had the highest nail toxicity rate (43.3%) and derazantinib the lowest (5.3%). Grade 1–2 events were most common; Grade 3 events prompted dose reduction in three patients out of 540, though no treatment discontinuations were reported. Common management strategies included antiseptic soaks, topical steroids, oral antibiotics, and protective nail care practices.

DISCUSSION/CONCLUSION:

The incidence of FGFRi-associated nail toxicities varies by agent and can affect quality of life and treatment adherence. The pathogenesis remains unclear, and no predictive biomarkers exist. Further research into optimized management and preventative strategies is needed. Early recognition and proactive multidisciplinary management are essential to minimizing complications and maintaining oncologic treatment continuity. .

2026-02-01·The Lancet Gastroenterology & Hepatology

Tinengotinib for adults with advanced or metastatic cholangiocarcinoma: a multicentre, open-label, phase 2 trial

Article

作者: Sahai, Vaibhav ; Richards, Donald ; Peng, Peng ; Cohn, Allen ; Javle, Milind ; Ni, Shumao ; Sun, Caixia ; Fountzilas, Christos ; Fonkoua, Lionel Kankeu ; Pelster, Meredith ; Wang, Hui ; Li, Daneng ; Kingsley, Edwin ; Fan, Jean ; Liao, Chih-Yi ; Mahipal, Amit ; Deming, Dustin ; Hennessy, Katie ; Wu, Frank ; Mantry, Parvez

BACKGROUND:

Cholangiocarcinoma is a rare, aggressive cancer often driven by FGFR2 fusions, which are targetable with inhibitors such as pemigatinib and futibatinib. However, resistance frequently develops due to acquired FGFR2 mutations. In this study, we aimed to evaluate the efficacy and safety of tinengotinib in previously treated patients with advanced cholangiocarcinoma.

METHODS:

This open-label, multicentre, phase 2 trial was done at 32 medical centres in the USA. Eligible patients were aged 18 years or older with advanced or metastatic cholangiocarcinoma, who had previous systemic chemotherapy, and an Eastern Cooperative Oncology Group score of 0-1. Patients were assigned to one of four cohorts on the basis of FGFR status: cohort A1, FGFR2 fusions with primary FGFR inhibitor resistance; cohort A2, FGFR2 fusions with acquired FGFR inhibitor resistance; cohort B, other FGFR alterations; or cohort C, FGFR wild-type. Patints orally self-administered tinengotinib 10 mg daily in 28-day cycles in 28-day treatment cycles until documented disease progression, unacceptable toxicity, or withdrawal of consent. The primary endpoint was objective response rate as per investigator assessment, defined as the proportion of patients with confirmed tumour response (complete response or partial response) that was redocumented 4 weeks or after initial assessment based on RECIST (version 1.1), as assessed by the investigator. The primary endpoint was assessed in the in the efficacy evaluable population, which included all patients who received at least one dose of tinengotinib, had measurable disease at baseline, and had at least one post-baseline tumour assessment. Safety assessed in all patients who received at least one dose of tinengotinib. This trial is registered with ClinicalTrials.gov, NCT04919642, and enrolment is complete.

FINDINGS:

Between Nov 19, 2021, and March 5, 2024, 55 patients were enrolled and assigned to one of four cohorts (cohort A1 [n=18], cohort A2 [n=11], cohort B [n=13], and cohort C [n=13]); all received tinengotinib. Patients had a median age of 61 years (IQR 56-68); 31 (56%) patients were female. All patients had received at least one previous systemic therapy. Median follow-up was 11·3 months (IQR 6·5-17·3). Among 51 patients included in the efficacy evaluable set, the objective response rate was 6·3% (95% CI 0·2-30·2; one confirmed partial response) in cohort A1, 30·0% (6·7-65·3; three confirmed partial responses) in cohort A2, 23·1% (5·0-53·8; three confirmed partial responses) in cohort B, and 0% in cohort C. Grade 3 treatment-related adverse events included hypertension in 17 (31%) of 55 patients, palmar-plantar erythrodysesthesia syndrome in seven (13%) patients, and stomatitis in six (11%) patients. Grade 4 treatment-related adverse events occurred in two (4%) of 55 patients (increased lipase [n=1] and posterior reversible encephalopathy syndrome [n=1]); no grade 5 treatment-related adverse events were reported.

INTERPRETATION:

These findings suggest that tinengotinib might have activity in patients with cholangiocarcinoma with FGFR2 fusions that progressed following FGFR inhibitor therapy. Anti-tumour activity was also observed in patients with other FGFR alterations. The data from this phase 2 study supported the initiation of a phase 3 registration trial.

FUNDING:

TransThera Sciences.

823

项与佩米替尼相关的新闻（医药）

18 小时之前

·EINPresswire

Gateway Celebrity Fight Night Delivers an Unforgettable Evening Directly Funding Early-Phase Cancer Research

Bryan Adams, David Foster, and Others Unite for Fundraiser, with 100% of Money Raised Directly Funding Early-Phase Cancer Research Gateway for Cancer Research is at the cutting edge of early-phase discovery, where bold ideas are transformed into life-changing possibilities.” — Dr. Stacie J. Stephenson, Vice-Chair Gateway for Cancer Research PHOENIX, AZ, UNITED STATES, March 24, 2026 / EINPresswire.com / -- Dr. Stacie J. Stephenson and Richard J Stephenson, Chairman and Vice-Chair of Gateway for Cancer Research , a nonprofit 501c(3) organization committed to funding innovative Phase I and Phase II cancer clinical trials, hosted Arizona’s premiere fundraising event of the season, Gateway Celebrity Fight Night , on Saturday, March 21st at the Fairmont Scottsdale Princess in Scottsdale, Arizona. The evening showcased the vibrant energy and dedication of the community coming together for a shared mission: to champion groundbreaking cancer research and highlight the importance of early-phase clinical trials in transforming patient care. This year’s Gateway Celebrity Fight Night drew entertainers, musicians, philanthropists, and leading medical experts to raise critical funds for early-phase cancer clinical trials, an area often overlooked and underfunded, yet essential to advancing the most promising new cancer drugs and therapies. Bryan Adams, Grammy Award winning singer and global rock icon, headlined the event with a dynamic private rock concert and featured renowned 16-time Grammy Award winning producer, David Foster, whose longstanding role as Musical Director continues to shape the event’s signature sound. The evening was emceed by cancer survivor, actor, and Broadway star Erich Bergen (Love Story, Madam Secretary), whose humor charmed and energized the room, plus powerhouse R&B vocalist Sheléa, and captivating jazz singer Brenna Whitaker, each delivering unforgettable performances that elevated the night’s celebration. Guests were also introduced to the powerful story of James “Chris” Kirk, a patient impacted by a Gateway-funded clinical trial after being diagnosed with stage four pancreatic cancer and a rare FGFR mutation found in only 1% of patients. Chris is under the care of Dr. Sameek Roychowdhury, a renowned physician at The Ohio State University Comprehensive Cancer Center, and Head of Gateway for Cancer Research’s Scientific Peer Review. Dr. Roychowdhury is leading an innovative Phase II study that uses telemedicine to deliver pemigatinib to pancreatic cancer patients with FGFR gene alterations. This approach allows patients like Chris to receive groundbreaking treatment from home, with medications shipped and labs handled locally. Early results show promising patient outcomes, giving Chris a renewed sense of HOPE and more time with his family. “Gateway for Cancer Research is at the cutting edge of early-phase discovery, where bold ideas are transformed into life-changing possibilities,” shared the evening’s host, Dr. Stacie J. Stephenson, integrative health expert and bestselling author. “Every breakthrough begins with courageous patients, visionary researchers, and a community of supporters who believe in what’s possible. Together, we are accelerating progress and bringing new hope to those who need it most.” “Gateway for Cancer Research continues to demonstrate what is possible when purpose and generosity come together,” said Gateway’s Founder, Richard J Stephenson. “We are deeply grateful for the extraordinary support of our donors and partners, whose commitment allows us to fund innovative research that has the potential to save lives.” The black-tie event featured a cocktail reception, elegant dinner and an exciting live auction including a one-of-a-kind sapphire and diamond ring, plus a brand-new 2026 Toyota Land Cruiser donated by Valley Toyota Dealers . For more information about Gateway for Cancer Research, visit https://www.gatewaycr.org. *** About Gateway for Cancer Research Gateway for Cancer Research℠ is a nonprofit 501c(3) organization committed to finding, funding and furthering innovative cancer research that helps cancer patients feel better and live longer as we work to end cancer as we know it. Thanks to generous underwriting by Dr. Stacie J. and Mr. Richard J Stephenson, 100% of every donation directly funds Phase I and Phase II cancer clinical trials at leading research institutions around the world. Since its inception in 1991, Gateway has invested more than $126 million to advance 249 cancer clinical trials. These studies have delivered HOPE and healing to more than 10,000 patients, altered the standard of care at some of the world's most trusted health care institutions, and contributed to new FDA-approved cancer treatments. Get involved today by visiting GatewayCR.org, like us on Facebook at GatewayCancerResearch and follow us on Instagram at @GatewayforCR, #GatewayCelebrityFightNight #CelebrityFightNight #BeAGateway #GatewayForCancerResearch #KnockOutCancer Jennifer McIntosh Krupp Agency +1 480-202-7112 email us here Visit us on social media: Instagram Facebook X Legal Disclaimer: EIN Presswire provides this news content "as is" without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.

临床2期

2026-03-24

·优亿美康

173份丨2026ESMO TAT靶向抗癌治疗大会原版PPT合集下载

点击上方"蓝字" 关注我们吧！作为全球肿瘤靶向治疗领域的风向标，欧洲肿瘤内科学会靶向抗癌治疗大会（ESMO TAT）于2026年3月16-18日在法国巴黎盛大开幕。本届大会延续其一贯的学术定位，深度聚焦早期药物开发与转化研究，旨在为学术界、工业界及监管机构搭建高水平的跨界交流平台。小优特地整理了该会议几乎全部173份原版PPT，为了方便阅读将标题翻译为中文，原版PPT为可编辑版本。小伙伴们扫描下方任意二维码加入知识星球，就可以获得这些全部内容。星球内已涵盖20000+肿瘤资料，分类清晰，覆盖全面，每日持续更新中！以下是内容目录，星球内已列出摘要号和中英文标题，搜索查找很方便 1.【摘要1MO】从双特异性到四特异性：通过优化T细胞活化应对肿瘤异质性 2.【摘要3P】HER2阳性转移性乳腺癌患者实现无疾病证据的临床意义：土耳其肿瘤学小组（TOG）的多中心研究 3.【摘要4P】恩美曲妥珠单抗（T-DM1）生物类似药（Ujvira）在早期HER2阳性乳腺癌中的真实世界疗效：一项来自印度的单中心回顾性研究 4.【摘要5P】T-DXd与dato-DXd联合DNA损伤反应抑制剂的协同活性 5.【摘要6P】TROP-2作为胃肠道肿瘤的治疗靶点 6.【摘要7P】抗TROP2抗体药物偶联物在子宫内膜癌患者来源类器官中的评估 7.【摘要8P】与维布妥昔单抗相比，肿瘤特异性抗CD30抗体偶联药物可减少可溶性CD30的消耗效应并提升体内疗效 8.【摘要9P】开发一种针对转移性前列腺癌适应症的肿瘤特异性抗TRPV6治疗性抗体 9.【摘要10P】HER3-DXd及其他TOP1抑制剂抗体药物偶联物在乳腺癌中持续获益的有效载荷中心决定因素：临床、转化及临床前证据的系统性回顾 10.【摘要12P】泛肿瘤外源DNA靶向抗体平台实现核内递送以降解蛋白质 11.【摘要13P】生理相关检测环境揭示抗体构建体的关键功能差异，标准缓冲条件未能捕捉 12.【摘要14P】关于抗CD3双特异性抗体临床试验中联合用药与细胞因子释放综合征发生及严重程度关联性的研究 13.【摘要15P】DLL3导向的T细胞重定向作为髓样甲状腺癌的治疗策略 14.【摘要16P】MDX2003，一种首创的CD19xCD20xCD3xCD28四特异性T细胞衔接器（TCE），对B细胞恶性肿瘤具有强效活性，并在自身免疫性疾病领域展现出潜力 15.【摘要17P】结构引导的鲨鱼源性VNARs的π调制实现药代动力学控制，用于诊疗一体化应用 16.【摘要18P】靶向MET表达型非小细胞肺癌的VNAR基诊疗一体化药物 17.【摘要19P】靶向人类肿瘤蛋白TCTP的纳米抗体设计与评估 18.【摘要20P】αTIGIT导向的IL-15模拟物通过重塑肿瘤浸润T细胞，驱动强效且安全的抗肿瘤免疫 19.【摘要21P】52gMn-DOTA免疫PET靶向FAP抗体成像 20.【摘要22P】接受恩诺单抗治疗的晚期尿路上皮癌患者的骨转移：来自ARON-2EV项目的真实世界研究 21.【摘要23P】仅缩小诊断差距尚不足够：BRAFV600E突变型转移性结直肠癌一线靶向治疗面临的现实障碍 22.【摘要24P】单细胞与批量RNA测序分析揭示胃肠道癌症中独特的抗体药物偶联物靶点 23.【摘要25TiP】一项评估MDX2004（一种三特异性抗体融合蛋白）单药治疗晚期肿瘤患者的Ⅰ／Ⅱa期、多中心、首次人体、开放标签临床试验 24.【摘要26eP】德曲妥珠单抗在HER2阳性或ERBB2突变肿瘤中的应用：真实世界临床实践数据 25.【摘要27eP】恩美曲妥珠单抗（T-DM1生物类似药Ujvira）在早期和转移性HER2阳性乳腺癌中的真实世界疗效与安全性：一项来自印度的多中心汇总回顾性分析 26.【摘要29P】人工智能与数字疗法：提升乳腺癌治疗反应预测模型 27.【摘要30P】整合剪切波弹性成像与肿瘤硬度的多模态转换器可预测癌症治疗反应 28.【摘要31P】群体学习支持多中心扩散生成模型在癌症影像中的应用 29.【摘要32P】全切片组织病理学嵌入技术可实现食管腺癌中非基因组HER2生物标志物的预测 30.【摘要33P】整合肾细胞癌性别差异的基于智能体的学习模型 31.【摘要34P】DREAM：通过整合分析与机器学习实现数据驱动的药物重定位 32.【摘要36P】通过AlphaMissense与结构建模对ATM和PALB2基因中9,534个胚系意义未明变异进行重新分类：揭示精准肿瘤学的预测靶点 33.【摘要37P】修正数据，而非模型：精准肿瘤学人工智能在低收入和中等收入国家面临的挑战 34.【摘要38eP】基于常规组织病理学在肺腺癌中利用人工智能识别TKI敏感驱动突变 35.【摘要42P】人类前列腺组织中阶段特异性长链非编码RNA特征可提升诊断精确度并预测侵袭性与去势抵抗性疾病 36.【摘要48P】源自患者模型的CAF特异性靶向策略协同抑制胰腺肿瘤进展与化疗耐药 37.【摘要49P】浆液性卵巢癌中细胞计数、肿瘤负荷与组织病理学表型的相关性：对作为ATMP的TILs疗法研发的启示 38.【摘要50eP】整合DNA测序、转录组学与生物信息学分析，实现前列腺癌精准医疗 39.【摘要51eP】靶向循环肿瘤细胞（CTC）的同种异体CAR-T细胞作为治疗可手术胰腺导管腺癌（PDAC）早期复发的新策略 40.【摘要52eP】肿瘤大小与浆液性卵巢癌细胞分离产量的相关性作为TIL疗法中ATMP生产的预测因素 41.【摘要53P】FTSJ3对TERRA的表观遗传调控支持端粒酶介导的致癌作用 42.【摘要54P】ALOX5驱动的脂质代谢通过增强DNA修复介导治疗耐药性 43.【摘要56P】长链非编码RNA FENDRR、LINC02560和SOX21-AS1调控晚期胃癌化疗耐药性 44.【摘要57TiP】PARPA-293-003：NMS-03305293（Itareparib，一种具有脑渗透性、非捕获型PARP1选择性抑制剂）联合拓扑替康治疗复发性HR阳性铂类耐药／难治性卵巢癌的Ⅰa／Ⅰb期研究 45.【摘要58TiP】PARPA-293-004：NMS-03305293（一种具有脑渗透性、非捕获性PARP1选择性抑制剂）联合替莫唑胺治疗复发性ES-小细胞肺癌的Ⅰb期研究 46.【摘要60O】HCB301（一种三特异性SIRPα-PD-1-TGFβ融合蛋白）首次人体Ⅰ期评估：安全性、药代动力学及多系统免疫激活 47.【摘要63P】帕博利珠单抗联合仑伐替尼治疗晚期肝细胞癌 48.【摘要64P】分子非选择性免疫疗法与非免疫疗法试验：英国莎拉坎农研究所（SCRI）难治性转移性去势抵抗性前列腺癌（mCRPC）的治疗结果 49.【摘要65P】铂类化疗后阿维鲁单抗维持治疗在晚期尿路上皮癌中的应用：真实世界疗效及后续治疗顺序 50.【摘要66P】HCB101联合标准治疗方案的安全性、药代动力学及转化特征早期研究：HCB101-201 Ⅰb／Ⅱa期试验结果 51.【摘要69eP】乳腺癌中新型免疫调节因子CD81和CD155通过复杂非编码RNA环路失调 52.【摘要70P】细胞因子模式作为潜在的预测性和预后性免疫治疗生物标志物 53.【摘要71P】T细胞衔接器治疗患者中细胞因子释放综合征、抗肿瘤反应与总生存期之间的关联：一项回顾性研究 54.【摘要72P】选择合适的搭档：化疗基础方案如何影响一线三阴性乳腺癌抗PD-(L)1治疗的疗效 55.【摘要73P】通过表观遗传重编程记忆基因转录回路增强CAR T细胞疗法 56.【摘要74P】T细胞双特异性抗体诱导的免疫相关不良事件缓解策略及其对T细胞功能的影响 57.【摘要75eP】粒细胞-巨噬细胞集落刺激因子武装的溶瘤新城疫病毒作为对比性免疫治疗平台 58.【摘要76P】通过计算识别TP53、KRAS和BRAF热点突变中的共享新抗原，用于泛癌治疗性疫苗开发 59.【摘要78P】PD-1抑制剂相关三重M（3M）综合征的非比例性分析 60.【摘要84eP】仑伐替尼联合帕博利珠单抗治疗晚期或复发性子宫内膜癌的真实世界临床结局：一项单中心队列研究 61.【摘要85eP】靶向实体瘤中的调节性T细胞：55种候选药物的临床开发分析 62.【摘要87eP】HLA-A_01状态与接受免疫检查点抑制剂治疗的早期临床试验患者生存期及疗效较差相关 63.【摘要89O】BMS-986504联合或不联合吉西他滨（GEM）+白蛋白结合型紫杉醇（nab-P）治疗携带纯合MTAP缺失（MTAP-del）的胰腺导管腺癌（PDAC）患者的CA240-0007研究 64.【摘要90O】新型PI3Kα抑制剂zovegalisib在PIK3CA突变HR+／HER2-晚期乳腺癌患者中的剂量优化：首次人体研究结果支持推荐Ⅲ期剂量 65.【摘要91O】PI3Kα抑制剂TOS-358的Ⅰ期研究结果 66.【摘要92MO】沃拉西德尼在既往接受过艾伏尼布治疗的IDH突变型胶质瘤患者中的疗效 67.【摘要94P】自噬在结直肠癌靶向治疗期间支持药物耐受性持续状态 68.【摘要96P】OC201与OC202e通过双重抑制胰腺癌中PKCε–NFκB信号通路和自噬，协同抑制上皮-间质转化（EMT）和转移 69.【摘要97P】膀胱癌细胞系中针对FGFR抑制剂的代偿性耐药机制研究 70.【摘要98P】利用患者来源模型优化CDK4／6抑制剂耐药乳腺癌的治疗策略 71.【摘要100P】低剂量双重靶向EGFR–VEGFR作为结直肠癌治疗的机制导向策略 72.【摘要101P】ATB0, +促进癌症干细胞特性及乳腺癌的早发 73.【摘要102P】通过抑制mTORC1和抗凋亡BCL-2家族蛋白诱导成人T细胞白血病／淋巴瘤细胞凋亡 74.【摘要103P】新型共价配体调节结直肠癌中蛋白酶体活性与组装 75.【摘要104P】Rb缺陷在乳腺癌细胞系和患者来源异种移植模型中诱导与ATR和PKMYT1协同抑制的合成致死效应 76.【摘要105P】发现强效且选择性PKMYT1抑制剂 77.【摘要106P】氧化应激条件下A549非小细胞肺癌细胞中ME-NRF2轴的药理学靶向研究 78.【摘要108P】胰腺癌中Kirsten大鼠肉瘤（KRAS）G12D抑制剂INCB161734与化疗、生长因子阻断或免疫疗法的潜在治疗组合的临床前评估 79.【摘要109P】宗艾替尼治疗既往经治的HER2突变晚期非小细胞肺癌：单中心经验 80.【摘要111P】非小细胞肺癌中EGFR与MET mRNA过表达现象：流行特征及靶向治疗敏感性分析 81.【摘要112P】阿法替尼在复发性及转移性头颈部癌症中的疗效评估 82.【摘要115P】脂质体伊立替康（HR070803）联合氟尿嘧啶和贝伐珠单抗作为晚期结直肠癌患者的二线治疗方案：一项Ⅱ期试验A组结果 83.【摘要117P】针对肺鳞状细胞癌可操作弱点的靶向化合物筛选 84.【摘要120eP】探索有丝分裂激活与细胞应激通路抑制在肿瘤细胞与非肿瘤细胞间的平衡关系 85.【摘要121eP】乳腺癌新疗法方案：丝裂原与细胞应激抑制剂联合应用 86.【摘要122eP】小分子抑制剂联合化疗在结肠癌和肝癌细胞中潜在协同作用的临床前研究 87.【摘要126eP】佩米替尼治疗FGFR2阳性胆管癌中伴随基因组改变的预后影响：意大利真实世界研究的分子分析 88.【摘要127MO】用于分析和可视化早期剂量探索肿瘤学试验中患者报告结果的实用工具包及建议：OPTIMISE-AR 89.【摘要128MO】体外诊断法规（IVDR）实施对肿瘤临床研究审批时间及可及性的影响 90.【摘要131P】与乳腺癌晚期诊断相关的死亡率和经济负担 91.【摘要133P】欧洲药品管理局针对致癌基因成瘾性非小细胞肺癌靶向疗法的审批监管差异 92.【摘要134P】CT homecare：去中心化临床试验的学术协调平台 93.【摘要135eP】在叙利亚接受口服靶向治疗的患者中，存在经济负担、地理障碍和治疗配给行为 94.【摘要136eP】基于血液学指标与临床特征的人工智能驱动列线图用于预测胃癌远处转移 95.【摘要137MO】接受ESCAT Ⅰ–Ⅱ级靶向治疗（TT）的患者在早期临床试验（EPCTs）中的疗效结果 96.【摘要138P】可切除肝门部胆管癌围手术期循环肿瘤DNA与外泌体微小RNA谱分析：一项液体活检对比研究 97.【摘要139P】新型外泌体液体RNA活检检测在肺癌领域的临床性能表现 98.【摘要140P】晚期实体瘤患者参与学术分子预筛计划（MPP）后未检出循环肿瘤 DNA（ND-ctDNA） 99.【摘要142P】循环肿瘤细胞的常规分离与深度分子特征分析 100.【摘要143P】癌症特异性TMB检测组合优化：构建经济高效的免疫治疗生物标志物检测框架 101.【摘要144P】基于全面基因组测序（CGP）的同源重组缺陷（HRD）评估显示，HRD阳性肿瘤中存在频繁的可靶向基因改变及更高的肿瘤突变负荷（TMB） 102.【摘要145P】胶质瘤同源重组缺陷特征分析 103.【摘要146P】基于NGS的肉瘤中MTAP和CDKN2A／B缺失特征分析：发生率、模式与治疗机遇 104.【摘要147P】肉瘤亚型中MTAP缺失的普遍性：基于AACR Project GENIE数据库的分析 105.【摘要148P】Mic60缺失作为侵袭性乳腺癌表型的驱动因素 106.【摘要150P】结直肠癌患者来源肿瘤类器官的空间药物蛋白质组学分析，用于识别新的预测性生物标志物 107.【摘要151P】影响活检依从性的变量：来自癌症核心欧洲（CCE）临床试验“篮子中的篮子”项目的经验教训 108.【摘要152P】晚期癌症患者肿瘤单测序后采用ESMO胚系检测指南 109.【摘要153eP】SNORD17在皮肤黑色素瘤中的致癌作用：一项综合性生物信息学分析 110.【摘要154eP】超越突变：整合IDH1-R132H状态与肿瘤地形学以优化高级别胶质瘤预后——来自北非军事精准肿瘤学队列的见解 111.【摘要155eP】侵袭性甲状腺癌与良性结节性甲状腺肿的微小RNA表达谱存在显著差异：为诊断提供潜在支持 112.【摘要156eP】接受纳武利尤单抗和贝伐珠单抗治疗的复发性胶质母细胞瘤患者的血液免疫相关生物标志物（CA209-9UP） 113.【摘要161P】重组人精氨酸酶与Bcl-2抑制剂及二甲双胍联合治疗在多种癌症中的协同效应 114.【摘要163P】联合药物筛选揭示胰腺癌亚型的治疗脆弱性 115.【摘要165P】叶酸标记的拓扑替康负载藻蓝蛋白纳米颗粒用于增强对卵巢癌细胞的疗效 116.【摘要166P】血红素通过铁死亡克服结直肠癌对西妥昔单抗的耐药性 117.【摘要168P】首创TET2激活剂作为抗癌新疗法 118.【摘要169P】EphA2、EphA3、EphB2和IL-13RA2作为儿童髓母细胞瘤和毛细胞星形细胞瘤的治疗靶点 119.【摘要170eP】子宫内膜癌肥胖患者的放射治疗相关毒性：仅与BMI有关吗？ 120.【摘要171P】系统性抗癌药物眼部毒性负担日益加重：一项为期4年的单中心分析 121.【摘要172eP】TASK研究：远程支持提升依从性与症状认知——一项旨在冲突影响环境中维持癌症患者生活质量的前瞻性干预研究 122.【摘要173P】前瞻性观察研究，旨在评估在居里研究所（IC）早期临床试验入组时，对晚期实体瘤患者支持性护理需求进行系统化、标准化评估的可行性 123.【摘要175P】胰腺酶替代疗法对胰腺导管腺癌相关胰腺酶缺乏症患者肠道微生物组及免疫反应的影响 124.【摘要176P】卵巢癌患者参与Ⅰ期临床试验的预后因素 125.【摘要177P】古斯塔夫·鲁西癌症中心早期临床试验中的长期应答者：一项回顾性观察研究 126.【摘要178eP】基质APOL4界定了一种免疫激活的成纤维细胞亚型，可预测多种癌症的铂类药物反应 127.【摘要179eP】NGAL与传统生物标志物在宫颈癌中的比较评估：基于随机森林方法 128.【摘要181eP】靶向甲状腺癌：苯并呋喃取代查尔酮化合物的体外分析 129.【摘要186eP】超声支气管镜引导下纵隔冷冻活检对晚期肺癌分子与免疫组化特征分析的贡献 130.【摘要187eP】GeneCa肿瘤基因组数据库：精准肿瘤学的决策支持工具 131.【摘要188eP】胃癌：止血放疗的贡献是什么？ 132.【摘要191eTiP】叙利亚TELE-TAT试验：一项关于在冲突地区接受口服靶向治疗患者中远程肿瘤学主动管理不良事件的实用性随机研究 133.ADC联合疗法 134.CAR可靶向多个目标：多靶点CAR T细胞 135.IND试验中的患者报告结局 136.把握癌症中合成致死性的表观遗传学方法 137.靶向疗法中的毒性管理：聚焦降解剂与细胞因子 138.靶向肿瘤微环境的抗体药物偶联物 139.调整早期药物研发原则，优化新型放射性配体疗法的开发路径 140.多特异性药物研发中的真实世界数据与监管科学 141.放疗诱导的合成致死效应：生物标志物与药物组合 142.放射配体疗法在前列腺癌患者治疗中不断演变的角色 143.放射性配体疗法在神经内分泌肿瘤患者管理中的演变角色 144.工程化三特异性和多价分子：针对选择性与效力的设计 145.合成致死性与结直肠癌免疫治疗背景下的脆弱性 146.监管视角：放射配体研发中的监管要点 147.精准试验设计：驾驭篮式、伞式和平台研究 148.利用成纤维细胞活化蛋白（FAP）靶向肿瘤 149.临床实践中的AI应用 150.临床视角：放射配体在患者管理中的临床应用 151.迈向肿瘤临床实践中RLT的安全整合：多学科协作、优化工作流程、放射防护措施与患者监测 152.人工智能在临床开发中的应用 153.人工智能在药物发现中的应用 154.设计与实施数字工具，以在研究路径中提升可及性、参与度及患者赋权 155.实体瘤细胞疗法的过去、现在与未来监管框架 156.实体瘤中的T细胞衔接器：早期临床开发的经验教训 157.数字与人工智能：肿瘤学临床试验的新方法 158.特邀嘉宾讨论：60O和61O 159.特邀嘉宾讨论：62MO、1MO与92MO 160.特邀嘉宾讨论：89O、90O及91O 161.特邀嘉宾讨论：137MO、127MO及128MO 162.通过新型合成致死策略攻克_不可成药_靶点 163.细胞疗法在产业中的挑战与机遇 164.新一代ADCs：机遇与挑战 165.一期临床试验新终点 166.以大脑为靶点的新型激酶抑制剂 167.用人工智能变革研发，优化肿瘤学临床试验 168.与降解剂联合用药的理论依据 169.预测抗体偶联药物毒性的生物标志物 170.早期临床试验中的毒性管理：策略与体系 171.针对实体瘤的细胞疗法：科学与现状 172.制药企业与监管机构的决策制定 173.肿瘤学中的降解剂：机制、模式与临床进展（以上内容仅供专业人员交流及学习之用，如有侵权，请联系我们删除）以上2026ESMO TAT大会原版PPT合集，戳链接或识别任意二维码加入知识星球即可阅读和下载，也可点击阅读原文获取常用及重点内容推荐 500+丨2025WCLC原版PPT及解读合集 1000+丨2025ASCO原版PPT及解读合集 900+丨2025ESMO原版PPT及解读合集 264份丨2025ESMO Asia原版PPT合集 351份丨2025CSCO学术年会PPT合集 1681份丨2024年肿瘤学术会议PPT合集 1510份丨最新肺癌学术会议PPT合集最新NCCN指南及中文版、解读合集附下载丨2025CACA指南合集（全29册） 140+丨肿瘤及放疗实用电子书合集国内肿瘤会议PPT合集汇总 2025肿瘤综合治疗会议 2025肿瘤免疫治疗大会 2025CSCO指南会 2025CSCO年度进展研讨会 2025肺议所思胸部肿瘤交流会 2025CACA肺癌整合治疗大会 2025胸部肿瘤MDT进展会议 2025肺癌规范化诊治大会 2025中美国际肺癌大会 2025第十届雄鹰论坛（胸部肿瘤） 2025肺癌多学科申城会议 2025CSCO肺癌规范化诊疗研修班 2025乳腺癌精准个体化诊疗大会 2025南北汇乳腺肿瘤论坛 2025CACA整合乳腺癌大会 2025肿瘤健康管理大会（乳腺癌） 2025杭州湘湖乳腺癌前沿论坛三星会-2025全国青年乳腺论坛 2025CACA乳腺癌中青年专家论坛 2025乳腺癌巴渝论坛 2025乳腺癌个体化治疗大会 2025乳腺肿瘤整合医学大会 2025北京大学消化肿瘤论坛 2025CSCO肝胆胰肿瘤大会 2025金陵消化肿瘤学术会议 2025华西消化道肿瘤论坛 2025CACA整合肝癌大会 2025上海结直肠癌大会 2025CSCO结直肠癌学术年会 2025浙江大学大肠癌学术论坛 2025头颈肿瘤学术会议 2025鼻咽癌前沿进展会议 2025CACA整合甲状腺癌大会 2025CACA妇科肿瘤年会 2025妇科肿瘤精准治疗会议 2025广东泌尿生殖肿瘤年会 2025CACA整合血液肿瘤大会 2025血液肿瘤两江论坛 2025CSCO神经内分泌肿瘤大会 2025CACA整合肿瘤放疗大会 2025消化道肿瘤精准放疗交流会 2025肿瘤-抗体偶联药物论坛 2025CACA肿瘤整合支持治疗大会 2025CACA肿瘤微创治疗大会共整理120+会议，仅展示部分，更多请加入知识星球后可全部获得优亿瘤研【20000+肿瘤知识库】 ✓共识指南：2025CSCO丨NCCN丨CACA丨官方指南丨专家共识等； ✓最新资料：肺癌丨乳腺癌丨胃癌丨肝癌丨食管癌丨结直肠癌丨妇科肿瘤丨泌尿肿瘤丨血液肿瘤丨骨与软组织肿瘤丨头颈部肿瘤丨放化疗丨影像诊断丨营养康复丨前沿研究等； ✓学术会议：CSCO丨CACA丨ASCO丨ESMO丨WCLC丨ELCC丨AACR等国内外会议视频及PPT； ✓相关书籍：内科学丨影像诊断丨放化疗丨基础科学丨免疫靶向等； ✓多端通用：微信小程序丨知识星球APP丨电脑网页版丨微信登录就能任意使用；点击阅读原文，获取资料

2026-03-24

·信达生物

直击国人减重痛点 | 信达生物公益科普展：以科学定义脂肪肝逆转新路径

为响应健康中国号召，3月21日至22日，由健康报主办，信达生物公益支持的“肥胖与脂肪肝早筛早治健康管理行动计划”在北京、上海落地，通过专家公益科普、脂肪肝筛查与义诊、肥胖和脂肪肝趣味知识打卡等，向公众倡导“科学减重，让脂肪肝可逆转1.2”的健康理念，帮助公众提升对“肥胖和脂肪肝”的正确认知。减重新痛点：脂肪肝敲响身体代谢警报在我国，肥胖合并脂肪肝的患者比例高达81.8%3。这已成为我国肥胖人群的主要特点，也是民众减重的真实痛点。究其原因，这与中国人的体质密切相关。与欧美肥胖人群常见的皮下脂肪不同，中国人的肥胖是以腹型肥胖为主，占比高达87.8%4。而腹型肥胖是大家通常说的“苹果身材”，容易导致腹部脂肪异常堆积，形成内脏脂肪和肝脏脂肪。根据《中国成人超重和肥胖预防控制指南》及《肥胖患者的长期体重管理及药物临床应用指南(2024版)》，基于中国人群体质，男性腰围≥90cm、女性腰围≥85cm，视为腹型肥胖5。更严重的是，这种腹型肥胖带来的是一场代谢危机。它的直接危害是肥胖合并脂肪肝，这正是身体代谢失衡的警报。北京大学人民医院感染与肝病中心，北京大学肝病研究所所长饶慧瑛表示：“脂肪肝已经成为威胁全民健康的重要代谢性疾病，尤其在肥胖人群中发病率显著攀升。脂肪堆积不仅直接损伤肝细胞，更会诱发胰岛素抵抗、慢性炎症，甚至激活肝纤维化。同时，脂肪肝常与糖尿病、心血管疾病等密切相关。” 对于减重人群来说，如何逆转脂肪肝，提升代谢水平，保持健康，是减重的重中之重。 GCG靶点破局，让脂肪肝可逆转春季被视为燃脂的黄金时间。然而，传统饮食调整、运动等单一体重管理方式，对腹型肥胖合并脂肪肝患者的健康改善效果有限。尤其仅仅关注掉秤的数字，而忽视内脏脂肪和肝脏健康，并非科学减重理念。在专家看来，通过科学减重，让脂肪肝可逆转，是亟待普及的科学理念。上海市第一人民医院内分泌代谢科副主任医师林毅表示：“很多患者盯着体重秤，却忽略了‘减什么、怎么减’，才是关键。对于腹型肥胖患者来说，内脏脂肪堆积以及可能引发的胰岛素抵抗，是对肝脏健康的巨大伤害。在减重的过程，保持燃脂护肝是主要衡量标准。” 玛仕度肽是全球首个且唯一获批的GCG/GLP-1天然双靶点减重药物6，是基于中国肥胖人群临床数据，适合中国人“腹型肥胖”的减重药7，科学减重，燃脂护肝，拥有代谢多重获益8。首都医科大学附属北京安贞医院内分泌代谢科副主任陶红表示：“GLP-1靶点可以通过缓解胃排空，帮患者管住嘴，而GCG靶点是直接激活肝脏脂肪分解通路，抑制肝脏脂肪合成，达到燃脂护肝的目的。可以说，玛仕度肽是比较精准匹配了中国人以内脏脂肪堆积为主的代谢特征，为肥胖合并脂肪肝、糖尿病等患者提供了创新健康管理方案。” 临床数据显示，使用指定剂量的玛仕度肽，体重降幅可达20%9，肝脏脂肪含量可降低80%10。作为中国硬科技，玛仕度肽的相关临床研究成果先后登顶国际医学研究顶刊《新英格兰医学杂志》、全球科学研究顶刊《自然》主刊。玛仕度肽III期临床研究DREAMS-3达成主要终点，实现与司美格鲁肽头对头胜出，展现降糖减重综合疗效优势11。从关注腰围开始，助力国家体重管理今年是国家体重管理年的关键之年，在全国两会上，通过呼吁大家关注腰围，做科学减重，成为了社会热点。腰围是衡量腹型肥胖的直观体现。而“肥胖与脂肪肝早筛早治健康管理行动计划”基于此创新了传统的医学科普形式，不仅有专家咨询、健康检测大巴车，更设置了多个创意互动体验区，打造了一个露天的“燃脂护肝集市”，吸引更多人群关注肥胖和脂肪肝的危害，提供兼具生活方式改善、医学干预等多元化的解决方案。现场，复旦大学附属华山医院内分泌科副主任医师苗青表示：“对于存在腹型肥胖的人群，应该及早进行脂肪肝的筛查。建议普通人群每年进行一次健康体检，将肝脏超声检查作为常规项目。对于已经确诊肥胖和脂肪肝的人群，应在专业医师指导下，及早进行科学干预，实现科学减重和脂肪肝的逆转。” 据了解，“肥胖与脂肪肝早筛早治健康管理行动计划”将陆续在全国范围内持续开展，通过倡导“科学减重，让脂肪肝可逆转”的健康理念，强化肥胖和脂肪肝科普，助力国人体重健康管理，提升全民健康水平。关于信达生物 - 滑动查看更多介绍 - “始于信，达于行”，开发出老百姓用得起的高质量生物药，是信达生物的使命和目标。信达生物成立于2011年，致力于研发、生产和销售肿瘤、自身免疫、代谢、眼科等重大疾病领域的创新药物，让我们的工作惠及更多的生命。公司已有18个产品获得批准上市，它们分别是信迪利单抗注射液（达伯舒®），贝伐珠单抗注射液（达攸同®），阿达木单抗注射液（苏立信®），利妥昔单抗注射液（达伯华®），佩米替尼片（达伯坦®），奥雷巴替尼片（耐立克®），雷莫西尤单抗注射液（希冉择®），塞普替尼胶囊（睿妥®），伊基奥仑赛注射液（福可苏®），托莱西单抗注射液（信必乐®），氟泽雷塞片（达伯特®），匹妥布替尼片（捷帕力®)，己二酸他雷替尼胶囊（达伯乐®），利厄替尼片（奥壹新®），替妥尤单抗N01注射液（信必敏®），玛仕度肽注射液（信尔美®），伊匹木单抗N01注射液（达伯欣®）和匹康奇拜单抗（信美悦®）。目前，5个新药分子进入III期或关键性临床研究，另外还有14个新药品种已进入临床研究。公司已与礼来、罗氏、武田、赛诺菲、Incyte和MD Anderson 癌症中心等国际合作方达成30多项战略合作。信达生物在不断自研创新药物、谋求自身发展的同时，秉承经济建设以人民为中心的发展思想。多年来，始终心怀科学善念，坚守“以患者为中心”，心系患者并关注患者家庭，积极履行社会责任。公司陆续发起、参与了多项药品公益援助项目，让越来越多的患者能够得益于生命科学的进步，买得到、用得起高质量的生物药。截至目前，信达生物患者援助项目已惠及20余万普通患者，药物捐赠总价值36亿元人民币。信达生物希望和大家一起努力，提高中国生物制药产业的发展水平，以满足百姓用药可及性和人民对生命健康美好愿望的追求。详情请访问公司网站：www.innoventbio.com或公司领英账号Innovent Biologics。声明： 1.信达不推荐任何未获批的药品/适应症使用。 2.雷莫西尤单抗注射液（希冉择®），塞普替尼胶囊（睿妥®）和匹妥布替尼片（捷帕力®）由礼来公司研发。前瞻性声明本新闻稿所发布的信息中可能会包含某些前瞻性表述。这些表述本质上具有相当风险和不确定性。在使用“预期”、“相信”、“预测”、“期望”、“打算”及其他类似词语进行表述时，凡与本公司有关的，均属于前瞻性表述。本公司并无义务不断地更新这些预测性陈述。这些前瞻性表述是基于本公司管理层在做出表述时对未来事务的现有看法、假设、期望、估计、预测和理解。这些表述并非对未来发展的保证，会受到风险、不确性及其他因素的影响，有些是超出本公司的控制范围，难以预计。因此，受我们的业务、竞争环境、政治、经济、法律和社会情况的未来变化及发展的影响，实际结果可能会与前瞻性表述所含资料有较大差别。本公司、本公司董事及雇员代理概不承担 (a) 更正或更新本网站所载前瞻性表述的任何义务;及 (b) 若因任何前瞻性表述不能实现或变成不正确而引致的任何责任。参考文献: *1.代谢相关脂肪性肝病基层诊疗与管理指南(2025年)[J].中华全科医师杂志，2025,24(05):513-525 *2. Targher et al.N Engl J Med. 2025 Aug 14;393(7):683-698 3. Chen K, et al. Prevalence of obesity and associated complications in China: A crosssectional, Real-world study in 15.8 million adults[J]. Diabetes Obes Metab, 2023, 25(11): 3390-3399. 4. 中华内分泌代谢杂志 2024年７月第40卷第7期 Chin J Endocrinol Metab, July 2024 Vol. 40, No 7 5. 倪国华等，中国肥胖流行的现状与趋势，中国食物与营养，2013,19(10):70-74; 6. Yanyun Chen, etc. 81st ADA Virtual;25-29 June 2021, 682-P 7. .Ji L, et al. N Engl J Med. 2025 May 25. doi: 10.1056/NEJMoa2411528. 8.Gabery S,et al.JCIInsight.2020Mar26;5（6):e133429 9. 来自玛仕度肽9mg 3期临床研GLORY-2，data on file 10. Ji L, et al. N Engl J Med. 2025 May 25. doi: 10.1056/NEJMoa2411528 11. 来自玛仕度肽DREAMS-3临床III期研究数据

临床结果

100 项与佩米替尼相关的药物交易

登录后查看更多信息

外链

KEGG	Wiki	ATC	Drug Bank
D11417	佩米替尼	L01XE	DB15102

研发状态

批准上市

10 条最早获批的记录,

后查看更多信息

适应症	国家/地区	公司	日期
晚期胆管癌	韩国	Handok, Inc.	2023-04-25
染色体8p11骨髓增殖综合征	美国	Incyte Corp.	2022-08-26
胆管癌	加拿大	Incyte Corp.	2021-09-17
局部晚期胆管癌	欧盟	Incyte Biosciences Distribution BV	2021-03-26
局部晚期胆管癌	冰岛	Incyte Biosciences Distribution BV	2021-03-26
局部晚期胆管癌	列支敦士登	Incyte Biosciences Distribution BV	2021-03-26
局部晚期胆管癌	挪威	Incyte Biosciences Distribution BV	2021-03-26
转移性胆管癌	欧盟	Incyte Biosciences Distribution BV	2021-03-26
转移性胆管癌	冰岛	Incyte Biosciences Distribution BV	2021-03-26
转移性胆管癌	列支敦士登	Incyte Biosciences Distribution BV	2021-03-26
转移性胆管癌	挪威	Incyte Biosciences Distribution BV	2021-03-26
FGFR2融合或重排的胆管癌	日本	Incyte Corp.	2021-03-23
FGFR2阳性肝内胆管癌	美国	Incyte Corp.	2020-04-17

未上市

10 条进展最快的记录,

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
不可切除的肝内胆管癌	临床3期	美国	Incyte Corp.	2019-06-03
不可切除的肝内胆管癌	临床3期	中国	Incyte Corp.	2019-06-03
不可切除的肝内胆管癌	临床3期	日本	Incyte Corp.	2019-06-03
不可切除的肝内胆管癌	临床3期	奥地利	Incyte Corp.	2019-06-03
不可切除的肝内胆管癌	临床3期	比利时	Incyte Corp.	2019-06-03
不可切除的肝内胆管癌	临床3期	加拿大	Incyte Corp.	2019-06-03
不可切除的肝内胆管癌	临床3期	丹麦	Incyte Corp.	2019-06-03
不可切除的肝内胆管癌	临床3期	芬兰	Incyte Corp.	2019-06-03
不可切除的肝内胆管癌	临床3期	法国	Incyte Corp.	2019-06-03
不可切除的肝内胆管癌	临床3期	德国	Incyte Corp.	2019-06-03

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ESMO_TAT2026	N/A	FGFR2阳性肝内胆管癌二线 FGFR2 fusion/rearrangement-positive	54	Pemigatinib (TP53 mutations)	簾廠繭糧膚憲膚艱糧淵(壓廠鑰餘鹽簾繭顧顧糧) = 壓鹽網顧築鏇鏇繭遞齋醖蓋鏇淵遞遞鏇憲繭衊 (餘糧蓋範醖範餘衊製衊 ) 更多	不佳	2026-03-16
				Pemigatinib (TP53 wild-type)	簾廠繭糧膚憲膚艱糧淵(壓廠鑰餘鹽簾繭顧顧糧) = 膚襯積鏇蓋廠淵鬱襯觸醖蓋鏇淵遞遞鏇憲繭衊 (餘糧蓋範醖範餘衊製衊 ) 更多
ESMO_SRC2026	N/A	中枢神经系统肿瘤	9	infigratinib	獵獵憲窪齋鏇願觸餘鏇(鏇網窪廠選夢淵鑰膚繭) = Toxicities included fatigue, visual changes, hyperphosphatemia and stomatitis. Two patients required dose reductions and four required discontinuation due to toxicity (visual changes - 1, hyperphosphatemia - 1 and fatigue - 2) 蓋壓淵鹽憲艱願鏇廠鹹 (衊膚網獵顧顧壓願醖遞 )	积极	2026-03-09
ESMO_SRC2026	N/A	琥珀酸脱氢酶缺陷型胃肠道间质瘤	19	imatinib	繭膚壓蓋憲鏇繭憲積觸(觸鹹夢遞壓鏇壓鑰遞鏇) = 壓鏇網糧餘襯蓋夢製膚築淵壓鹽蓋顧壓願獵製 (夢糧糧觸憲壓憲簾構糧, 50.7 ~ NR)	积极	2026-03-09
				sunitinib	廠築繭願醖選網繭範遞(鏇夢繭糧製鹽憲窪繭淵) = 觸憲鏇範憲鏇鹹憲壓膚齋蓋製選積糧衊壓鏇遞 (蓋醖範廠願網選繭鬱築 )
NCT05267106 (FIGHT-209, CTgov)	临床2期	多形性胶质母细胞瘤 \| 胶质母细胞瘤，IDH野生型 \| 胶质母细胞瘤 ... 更多	83	pemigatinib (Recurrent Glioblastoma)	範遞鏇淵顧衊淵簾夢餘 = 廠觸鹹糧窪窪範獵鏇範觸壓齋膚鑰網蓋鹹遞衊 (鹽齋鹹繭網壓積齋壓蓋, 壓願膚繭簾壓獵衊鹽範 ~ 艱鹽獵選蓋選構鹹繭鏇) 更多	-	2025-12-30
				pemigatinib (Recurrent Non-glioblastoma CNS Tumors)	鏇遞糧夢觸淵顧鬱壓顧 = 壓齋夢遞範獵膚製衊膚鑰壓醖艱夢膚鑰願願選 (鏇繭鹹範蓋襯廠構憲築, 製範壓壓顧遞製選鹽夢 ~ 網網醖鏇襯築衊積壓窪) 更多
NCT03011372 (FIGHT-203, CTgov)	临床2期	髓系肿瘤 \| 血液肿瘤 \| 骨髓增生性疾病	47	Pemigatinib	夢衊願夢獵鏇獵艱獵範 = 顧淵夢鬱憲鑰壓網繭艱淵選壓襯製齋積夢構齋 (遞願簾範獵簾範鏇鹹築, 網積範壓窪遞廠糧齋齋 ~ 願糧選範鏇鏇窪築窪窪) 更多	-	2025-11-18
JPRN-UMIN000053840 (JON2303 B, ESMO_GI2025)	临床2期	FGFR2 fusion gene \| FGFR2 gene rearrangement \| BAP1 alteration ... 更多	71	Pemigatinib	齋壓蓋夢繭壓夢願憲鏇(顧廠繭選簾觸糧遞選憲) = 膚繭遞鹹蓋範觸選築衊蓋憲觸鹽獵齋壓簾獵願 (壓觸繭壓餘衊壓鹽窪鏇 ) 更多	积极	2025-07-03
NCT04096417 (Pubmed \| Oncologist)	临床2期	结直肠癌	-	Pemigatinib	廠鏇積製簾艱艱獵襯蓋(醖廠網顧膚築構範願簾) = grade 3 or higher AE, 42.9% 齋觸糧鹹齋糧顧衊壓糧 (範鏇獵衊艱鹹窪膚醖築 ) 更多	-	2025-06-04
NCT05267106 (FIGHT-209, ASCO2025)	临床2期	胶质母细胞瘤 \| 胶质瘤 FGFR1-3 fusion/rearrangement \| FGFR1 mutation	-	Pemigatinib 13.5 mg	鹹築衊構築鹹願遞壓廠(遞鑰鬱鏇醖簾選構衊範) = 憲鬱觸願鹽鬱鏇選願夢齋蓋選窪鹽襯獵構廠鹹 (醖積齋壓築網憲遞製鏇 ) 更多	不佳	2025-05-30
				Placebo	鹹築衊構築鹹願遞壓廠(遞鑰鬱鏇醖簾選構衊範) = 鏇鏇醖醖構製顧餘觸鏇齋蓋選窪鹽襯獵構廠鹹 (醖積齋壓築網憲遞製鏇 ) 更多
NCT04294277 (PEGASUS, CTgov)	临床2期	膀胱尿路上皮癌	2	Pemigatinib	獵齋窪醖繭範構選餘艱(製鬱繭鹽鏇鹹築窪構壓) = 簾鏇遞鏇齋選齋襯鬱選襯鑰積鑰觸選糧夢鑰壓 (簾廠窪窪積淵淵襯範繭, 廠淵鹽觸獵鬱鏇淵鹹鹹 ~ 衊齋糧積願夢鑰夢醖積) 更多	-	2025-04-18
ESMO_TAT2025	N/A	胆道癌一线 molecular alterations	666	Targeted Therapy	選觸膚糧鬱鹹夢憲鬱築(繭範襯簾壓艱壓網夢夢) = 蓋築遞製網築鬱顧鏇積壓鏇鏇鬱夢獵積鑰廠遞 (遞鏇顧鬱積積積願鹽襯, 13.9 ~ 29.1) 更多	积极	2025-03-03
				Chemotherapy	選觸膚糧鬱鹹夢憲鬱築(繭範襯簾壓艱壓網夢夢) = 範衊網壓齋醖廠糧鏇淵壓鏇鏇鬱夢獵積鑰廠遞 (遞鏇顧鬱積積積願鹽襯 )