A Phase 2, Multicenter, Study Evaluating the Efficacy, Safety, Tolerability, Pharmacokinetics of KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GI Stromal Tumor in 1st Line Setting

This study will test an experimental drug called KQB198 in combination with imatinib. The goal is to determine if this combination is safe and tolerable and assess how effective the combination is at treating GIST. Imatinib has been approved by the FDA for the treatment of different types of cancer including GIST.

开始日期2026-04-01

申办/合作机构

Kumquat Biosciences, Inc.

NL-OMON57005

/ SuspendedN/AIIT

Microsampling for therapeutic drug monitoring of imatinib, dasatinib, nilotinib, gilteritinib, midostaurin, and venetoclax - Microsampling Oral Oncolytics

开始日期2026-02-01

申办/合作机构-

100 项与甲磺酸伊马替尼相关的临床结果

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100 项与甲磺酸伊马替尼相关的转化医学

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100 项与甲磺酸伊马替尼相关的专利（医药）

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16,775

项与甲磺酸伊马替尼相关的文献（医药）

2026-12-31·Gut Microbes

Fusobacterium nucleatum plays a pathogenic role in a murine model of irritable bowel syndrome by modulating intestinal purine metabolism and promoting mast cell activation

Article

作者: Zhou, Yesheng ; Hou, Songyuan ; Zhu, Jiaqi ; Ye, Haozhen ; Zhu, Shengtao ; Ning, Tingting ; Wang, Chenxu ; Liu, Si ; Zhang, Nan ; Lu, Shaochong ; Yang, Xinyi

Gut microbiota dysbiosis has been implicated in the pathogenesis of irritable bowel syndrome (IBS), a globally prevalent functional gastrointestinal disorder; however, mechanistic insights remain limited. We determined that the bacterium Fusobacterium nucleatum (F. nucleatum) played a pathogenic role in a murine model of IBS. Monocolonization of antibiotic-treated or germ-free mice with F. nucleatum induced IBS-like symptoms, including visceral hypersensitivity, increased fecal water content, and accelerated gastrointestinal transit, accompanied by mast cell activation. These effects were effectively prevented by treatment with the antibiotic metronidazole, as well as by the mast cell depleting agent imatinib or the mast cell stabilizer sodium cromoglicate. Mechanistically, F. nucleatum upregulated the expression of purine nucleoside phosphorylase (PNP) in intestinal epithelial cells (IECs), a key enzyme in the purine degradation pathway. The elevated PNP activity promoted purine degradation and uric acid production in IECs, which in turn directly activated mast cells. This F. nucleatum-driven mast cell activation mediated IBS-like symptoms in ABX treated mice but was abrogated by blocking uric acid synthesis. In summary, our findings highlight the crucial role of purine metabolism reprogramming and low-grade mucosal immune responses in F. nucleatum-mediated IBS-like symptoms in mice, providing promising therapeutic perspectives for targeting F. nucleatum-positive IBS patients.

2026-04-01·ENVIRONMENTAL POLLUTION

Polystyrene nanoplastics exacerbate dibutyl phthalate-induced liver fibrosis through PDGFRα-dependent hepatic stellate cell activation

Article

作者: Zhou, Tong ; Baek, Eun Bok ; Prayoga, Anjas Happy ; Lee, Jae-Ho ; Yamamura, Aya ; Ko, Eun-A ; Kang, Dawon ; Kim, Eun-Jin ; Ko, Jae-Hong ; Lee, Hyang-Ae ; Jung, Sung-Cherl ; Yamamura, Hisao ; Nashar, Ahmad Awwalun

Nanoplastic particles (NPs) derived from common polymers such as polyvinyl chloride and polystyrene (PS) act as persistent environmental reservoirs that facilitate the transport and cellular internalization of dibutyl phthalate (DBP), a ubiquitous plasticizer contaminating air, water, soil, and food through plastic leaching. The platelet-derived growth factor receptor α (PDGFRα) pathway is a well-established regulator of hepatic stellate cell (HSC) activation and fibrogenesis; however, its mechanistic involvement in plastic particle-induced hepatotoxicity and its intersection with DBP-mediated fibrosis remain unclear. Using HSC-hepatic cell cocultures (LX-2-HepG2 or LO2) and transcriptomic profiling, we demonstrate that DBP exposure markedly decreases hepatic cellular viability, elevates proinflammatory cytokines (TNF and IL-6), and induces apoptosis. In parallel, DBP stimulates LX-2 proliferation and upregulates fibrogenic markers (TGFB1, COL1A1, ACTA2) along with enhanced secretion of PDGF-A and PDGF-B, thereby reinforcing hepatic cell injury through paracrine signaling. RNA-seq analysis revealed activation of apoptotic and TNF-related pathways in LO2, whereas LX-2 cells exhibited upregulation of oncogenic and PI3K-Akt signaling, collectively promoting a profibrotic transcriptional landscape. In vivo, both PDGFRα antibody neutralization and pharmacological inhibition with imatinib significantly attenuated DBP-induced hepatic fibrosis and inflammatory gene expression, confirming PDGFRα's central role in DBP toxicity. Polystyrene nanoplastics (PS-NPs) were rapidly internalized by PDGFRα-positive primary HSCs within 24 h, leading to increased PDGFRα and PI3K expression. Co-exposure to PS-NPs and DBP resulted in synergistic hepatotoxicity and exacerbated fibrotic injury, demonstrating compounding effects of mixed environmental pollutants. Collectively, these findings identify PDGFRα as a mechanistic nexus linking DBP and PS-NPs exposure to hepatic fibrosis and highlight its potential as a therapeutic target for environmentally induced liver disease. The results further underscore the importance of co-exposure paradigms in evaluating the health risks of complex contaminant mixtures.

2026-03-01·CELLULAR SIGNALLING

Roxadustat induces erythroid differentiation of erythroleukemia cells through the hypoxia inducible factor-α/GATA binding protein 1 axis

Article

作者: Chen, Yuanzhong ; Lin, Jia ; Luo, Zhehan ; Wu, Yong ; Yang, Liqing ; Wang, Shuang

BACKGROUND:

Acute erythroleukemia (AEL) is a rare type of acute myeloid leukemia characterized by severe anemia. Roxadustat is a marketed first-generation hypoxia inducible factor-proline hydroxylase inhibitor (HIF-PHI), currently widely used in anemia associated with chronic kidney disease. Studies on roxadustat in anemia related to myeloid neoplasms remains limited.

METHODS:

Erythroid differentiation levels of HEL and K562 cells after roxadustat treatment were assessed via flow cytometry and benzidine staining. Real timequantitative PCR and western blot were performed to detect mRNA and protein expression levels of erythroid differentiation-related genes. Small interfering RNA (siRNA) was used to knock down HIF-1α or HIF-2α to elucidate the primary target of roxadustat-induced erythropoiesis. To study the role of GATA binding protein 1 (GATA1) in roxadustat-induced erythropoiesis, CRISPR/Cas9-mediated GATA1 knockout cell lines were established. Chromatin immunoprecipitation-PCR and dualluciferase reporter assay were conducted to determine the interaction between HIF-α and GATA1.

RESULTS:

Roxadustat significantly promoted erythroid differentiation in HEL and K562 cells. Knockdown of HIF-2α rather than HIF-1α, and knockout of GATA1 both effectively inhibited this effect. Both HIF-1α and HIF-2α are responsible for the direct upregulation of GATA1 expression under hypoxia, with HIF-1α as the dominant transcription factor. Despite potentially different roles of HIF-1α and HIF-2α in leukemogenesis, roxadustat combined with ruxolitinib or imatinib exhibited synergistic anti-leukemia effect in HEL and K562 cells, respectively.

CONCLUSIONS:

Roxadustat induces erythropoiesis in erythroleukemia cells primarily by targeting HIF-2α and was partially GATA1-dependent. Besides upregulating erythropoietin, our study revealed the HIF-α/GATA1 axis as another critical regulatory mechanism for hypoxia-driven erythropoiesis.

2,391

项与甲磺酸伊马替尼相关的新闻（医药）

2026-02-23

·Firstwordpharma

Gossamer's inhaled Winrevair rival fails PAH study

Gossamer Bio's bid to muscle into a market now reshaped by Merck & Co.'s Winrevair (sotatercept) stumbled Monday after its Phase III PROSERA trial fell short of a prespecified statistical bar in patients with pulmonary arterial hypertension (PAH), triggering an 81% drop in company shares.Seralutinib produced a placebo-adjusted improvement of 13.3m in six-minute walk distance (6MWD) at week 24, with a p-value of 0.032, which is below the conventional 0.05 threshold, but not the stricter 0.025 alpha set for the trial.PROSERA enrolled 390 patients with WHO Functional Class II or III PAH already on background therapy, more than half of whom were on triple or quadruple regimens. Patients receiving seralutinib – an inhaled PDGFRα/β, CSF1R, and c-KIT inhibitor delivered by dry powder inhaler – improved a median 28.2m from baseline.Jefferies analysts noted that Gossamer had powered its trial assuming a "+/- 2m placebo response," similar to the Phase III STELLAR study used to back Winrevair's regulatory approvals, "but much lower than most studies on average."Overall, placebo recipients in PROSERA improved by 13.5m from baseline, with pronounced regional variation.Subgroup signalGossamer said the strongest signal was seen in a subgroup of intermediate- and high-risk patients (n=234), a cohort where seralutinib delivered a 20m placebo-adjusted improvement in 6MWD (p=0.0207) – consistent with the earlier Phase II TORREY study – and three of four key secondary endpoints crossed nominal thresholds."We are disappointed to have narrowly missed the stringent prespecified statistical threshold for our primary endpoint," CEO Faheem Hasnain said, but noted the higher-risk cohort represents a "clearly defined and readily identifiable population," a finding he believes is "compelling on its own."Regional disparities appeared to complicate interpretation. North America (n=75) showed the greatest gain in 6MWD with a 25.9m placebo-adjusted benefit, but placebo responses in parts of Asia, the Middle East, Eastern Europe and Latin America were substantially higher, in some cases erasing treatment differences. Jefferies analysts noted that placebo-adjusted 6MWD appeared to vary in the Phase III trial of Winrevair as well, but "it's tough to say if this is a dynamic that's broadly seen in PAH or if it was specific to [Gossamer]."'Complicated' regulatory pathMeanwhile, Guggenheim's Vamil Divan wrote that even if seralutinib could have a role in helping patients with more severe PAH and those with underlying connective tissue disorders, "the regulatory pathway…even in those subgroups of patients will be complicated."Gossamer is co-developing the drug in partnership with Italian pharma Chiesi Farmaceutici under a 2024 deal worth up to $486 million.Monday's readout marks the second clinical fumble for an inhaled PAH therapy in almost two years. In 2024, Aerovate Therapeutics reported a mid-stage failure of AV-101, a dry powder inhaled formulation of imatinib. That setback was followed by layoffs and an eventual reverse merger with a Paragon Therapeutics spinout.

临床3期临床结果临床2期临床失败

2026-02-22

·今日头条

中国生物医疗走在世界前列中国生物医疗已从跟跑到并跑、多领域全球领跑，成为全球第二大新药研发国、最大临床研究市场、创新药输出大国，2025–2026年进入原创爆发、临床落地、普惠大众的黄金期。一、全球地位：权威认证的“第一梯队” 全球第二大新药研发国：在研新药1250+种，接近美国

中国生物医疗走在世界前列中国生物医疗已从跟跑到并跑、多领域全球领跑，成为全球第二大新药研发国、最大临床研究市场、创新药输出大国，2025–2026年进入原创爆发、临床落地、普惠大众的黄金期。一、全球地位：权威认证的“第一梯队” 全球第二大新药研发国：在研新药1250+种，接近美国（1440种），远超欧盟。全球最大临床研究市场：临床试验占全球1/3（2024年7100+项），患者招募效率为美国2.5倍。创新药输出第一：2025年对外授权1357亿美元，占全球50%；美国药企管线1/3新化合物来自中国。顶刊话语权：《柳叶刀》《细胞》《自然》年度突破性研究30%+来自中国；ESMO 2025四大肿瘤突破3篇中国主导。规则制定者：牵头制定全球首个干细胞国际标准，WHO临床试验平台中国主导项目44%。二、领跑领域：中国原创，全球首发 1. 细胞与基因治疗（CGT）：全球第一阵营体内CAR‑T（石药，2026.2）：全球领先，百万→十万级、1天制备、低毒。红细胞‑PD‑1（西湖大学，2026.2）：全球首个红细胞免疫药，PD‑1耐药缓解率42.9%。无需清淋TIL（君赛GC101）：晚期实体瘤缓解率40%+，最长无瘤生存超4年。异体iPSC治帕金森（解放军总医院，2026.2）：运动评分改善42.3%，78.6%患者震颤消失。首款国产干细胞药（艾米迈托赛，2025.1）：全球首个获批间充质干细胞药，1.98万元/次。 2. 免疫抗癌：中国方案改写全球指南双抗出海创纪录：荣昌RC148（56亿美元）、三生SSGJ‑707（12.5亿美元），刷新全球BD纪录。 TCR精准改造（中科院，2026.2）：抗癌活性↑10倍、副作用↓90%，发表《细胞》。肝癌全球防治框架（樊嘉/周俭院士，2025）：《柳叶刀》创刊200年首次中国主导全球肿瘤战略。 3. 创新药与生物制造：从“中国仿制”到“中国原创” 首创新药爆发：2025年获批76个创新药、76个创新器械，历史新高。 ADC/双抗/蛋白降解：全球交易占比70%，10+获FDA突破性疗法。生物催化革命（北大雷晓光，2026.1）：伊马替尼合成成本↓50%，绿色制造全球领先。

免疫疗法细胞疗法抗体药物偶联物基因疗法

2026-02-22

·道道之道

【本周医刊】2026年第8周医学期刊更新

2026年第8周（2026.02.15-2026.02.21）重要医学期刊论著更新如下： 1.综合期刊 LANCET 题目：Tenecteplase versus standard medical treatment for basilar artery occlusion within 24 h (TRACE-5): a multicentre, prospective, randomised, open-label, blinded-endpoint, superiority, phase 3 trial 翻译：替奈普酶对比标准药物治疗 24 小时内基底动脉闭塞（TRACE‑5）：一项多中心、前瞻性、随机、开放标签、终点盲法、优效性Ⅲ期临床试验题目：Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial 翻译：重组凝血因子Ⅶa对比安慰剂用于症状发作2 小时内自发性脑出血（FASTEST）：一项多中心、双盲、随机、安慰剂对照Ⅲ期临床试验题目：Cumulative incidence of advanced breast cancer in women aged 40–49 years in the Japan Strategic Anti-cancer Randomised Trial (J-START) of adjunctive ultrasonography: a prespecified secondary analysis 翻译：日本附加超声筛查抗癌随机试验（J‑START）中40～49岁女性晚期乳腺癌累积发病率：一项预设亚组分析题目：Efimosfermin alfa (BOS-580) once per month in people with metabolic dysfunction-associated steatohepatitis with F2 or F3 fibrosis: results from a 24-week, randomised, double-blind, placebo-controlled, phase 2 trial 翻译：艾菲莫肽 α（BOS‑580）每月一次治疗F2/F3 纤维化代谢相关脂肪性肝炎：一项24 周、随机、双盲、安慰剂对照Ⅱ期临床试验结果 NEW ENGLAND JOURNAL OF MEDICINE 题目：Teclistamab plus Daratumumab in Relapsed or Refractory Multiple Myeloma 翻译：泰莱斯塔单抗联合达雷妥尤单抗治疗复发或难治性多发性骨髓瘤题目：Hematopoietic Stem-Cell Gene Therapy for Cystinosis 翻译：胱氨酸病的造血干细胞基因治疗题目：An Antibody–Oligonucleotide Conjugate for Myotonic Dystrophy Type 1 翻译：用于 1 型强直性肌营养不良的抗体- 寡核苷酸偶联物题目：Transcatheter or Surgical Aortic-Valve Replacement in Low-Risk Patients at 7 Years 翻译：低危患者经导管或外科主动脉瓣置换术后7 年结局 JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 题目：Expectant Management vs Medication for Patent Ductus Arteriosus in Preterm Infants: The PDA Randomized Clinical Trial 翻译：期待治疗对比药物治疗早产儿动脉导管未闭：PDA随机临床试验题目：Cryopreserved vs Liquid-Stored Platelets for the Treatment of Surgical Bleeding: The CLIP-II Randomized Noninferiority Clinical Trial 翻译：冻存血小板对比液态保存血小板治疗外科出血：CLIP‑II随机非劣效性临床试验题目：Prenatal Exposure to Acid-Suppressive Medications and Risk of Neuropsychiatric Disorders in Children 翻译：产前暴露于抑酸药物与儿童神经精神疾病发病风险的关系 NATURE MEDICINE 题目：Colonoscopy and fecal immunochemical testing versus usual care in diagnostic colorectal cancer screening: the SCREESCO randomized controlled trial 翻译：结肠镜联合粪便免疫化学检测对比常规方案用于结直肠癌诊断性筛查：SCREESCO随机对照试验题目：Predicting onset of symptomatic Alzheimerʼs disease with plasma p-tau217 clocks 翻译：血浆 p-tau217 时钟预测症状性阿尔茨海默病发病题目：Bispecific T cell engagers for treatment-refractory autoimmune connective tissue diseases 翻译：双特异性 T 细胞衔接器用于治疗难治性自身免疫性结缔组织病题目：Deciphering the etiology of the 2024 outbreak of undiagnosed febrile illness in Panzi, Democratic Republic of the Congo 翻译：解析刚果民主共和国潘齐市 2024 年不明原因发热疫情的病因题目：Effects of a comprehensive antibiotic stewardship program on antibiotic prescribing for acute respiratory infections in rural facilities: a cluster randomized trial 翻译：综合性抗生素管理项目对基层医疗机构急性呼吸道感染抗生素处方的影响：一项整群随机试验题目：A short-acting psychedelic intervention for major depressive disorder: a phase IIa randomized placebo-controlled trial 翻译：短效致幻剂干预治疗重度抑郁症：一项Ⅱa期随机安慰剂对照试验题目：A quantitative DOPA decarboxylase biomarker for diagnosis in Lewy body disorders 翻译：用于路易体病诊断的定量多巴脱羧酶生物标志物 BMJ-BRITISH MEDICAL JOURNAL 题目：Menopausal hormone therapy and long term mortality 翻译：绝经激素治疗与长期死亡率题目：Vitamin D supplementation before in vitro fertilisation in women with polycystic ovary syndrome 翻译：多囊卵巢综合征女性体外受精前的维生素D 补充 INNOVATION（本周无更新） LANCET DIGITAL HEALTH（本周无更新） NPJ DIGITAL MEDICINE 题目：A large-scale benchmark for evaluating large language models on medical question answering in Romanian 翻译：面向罗马尼亚语医学问答的大语言模型大规模基准评测题目：Artificial intelligence–enhanced microsurgical training: a systematic review 翻译：人工智能增强的显微外科培训：一项系统评价题目：Defining operational safety in clinical artificial intelligence systems 翻译：临床人工智能系统中操作性安全性的定义题目：CancerLLM: a large language model in cancer domain 翻译：CancerLLM：一款肿瘤领域专用大语言模型题目：Robust and interpretable unit level causal inference in neural networks for pediatric myopia 翻译：基于神经网络的儿童近视个体水平稳健可解释因果推断题目：Large language models in systematic review and meta-analysis of surgical treatments for vaginal vault prolapse 翻译：大语言模型在阴道穹隆脱垂手术治疗系统评价与Meta 分析中的应用题目：Hierarchical deep learning pipeline for robust cervical parameter measurement in radiographs with C7 obscuration 翻译：针对 C7 节段遮挡X 光片的稳健性颈椎参数测量分层深度学习流程题目：Benchmarking large language model-based agent systems for clinical decision tasks 翻译：面向临床决策任务的大语言模型智能体系统基准测试题目：Computer vision applications in vascular surgery: a systematic review and critical appraisal 翻译：计算机视觉在血管外科中的应用：一项系统评价与批判性评价题目：Empowering genetic discoveries and cardiovascular risk assessment by predicting electrocardiograms from genotype 翻译：通过基因型预测心电图以助力遗传学发现与心血管风险评估题目：BRIDGE pilot study: a bilateral regulatory investigation of data governance and exchange 翻译：BRIDGE 试点研究：一项关于数据治理与数据交换的双边监管调查题目：Artificial intelligence-based incident analysis and learning system to enhance patient safety and improve treatment quality 翻译：基于人工智能的不良事件分析与学习系统：提升患者安全与治疗质量题目：Health economic simulation modeling of an AI-enabled clinical decision support system for coronary revascularization 翻译：面向冠脉血运重建的人工智能临床决策支持系统卫生经济学模拟建模题目：A deep learning model integrating structured data and clinical text for predicting atrial fibrillation recurrence 翻译：整合结构化数据与临床文本的深度学习模型预测心房颤动复发题目：Risk Prediction of Chronic Kidney Disease Progression in Type 2 Diabetes Mellitus Across Diverse Populations 翻译：不同人群中 2 型糖尿病患者慢性肾脏病进展的风险预测题目：Randomized-controlled trial of skills-based vr vs. distraction vr vs. sham VR for chronic low back pain 翻译：基于技能的虚拟现实、分散注意力虚拟现实与假虚拟现实治疗慢性下腰痛的随机对照试验题目：Bridging radiology and pathology: domain-generalized cross-modal learning for clinical 翻译：桥接放射学与病理学：面向临床的域泛化跨模态学习 2.肿瘤学 CA-A CANCER JOURNAL FOR CLINICIANS（本周无更新） ANNALS OF ONCOLOGY 题目：Cabozantinib plus nivolumab and ipilimumab in previously untreated, advanced renal cell carcinoma: final results and biomarker analyses from the phase III COSMIC-313 study 翻译：卡博替尼联合纳武利尤单抗 + 伊匹木单抗治疗初治晚期肾细胞癌：Ⅲ期COSMIC-313 研究最终结果与生物标志物分析题目：Learning the Forest Before the Trees: Artificial Intelligence and Thymic Tumor Pathology 翻译：先见森林后见树木：人工智能与胸腺肿瘤病理学题目：ESMO Adaptation of Lines of Systemic Therapy (EnLiST): a consensus framework for standardising the designation of lines of therapy in solid tumours 翻译：ESMO 系统性治疗线数适配方案（EnLiST）：实体瘤治疗线数定义标准化共识框架题目：Doubting T(h)OMAS: Has the era of precision oncology arrived in uterine leiomyosarcoma? 翻译：质疑 T (h) OMAS：精准肿瘤学时代是否已降临子宫平滑肌肉瘤？题目：PET/CT-Guided Management of Immune Checkpoint Blockade and Post-Treatment Multi-Modal Profiling in Long-Term Responders with Metastatic Lung Cancer in the National Network Genomic Medicine Lung Cancer Germany (nNGM) 翻译：德国国家肺癌基因组医学网络（nNGM）：转移性肺癌长期应答者的PET/CT 指导下免疫检查点阻断治疗管理及治疗后多组学分析 JOURNAL OF CLINICAL ONCOLOGY 题目：Hepatic Arterial Infusion Pump Chemotherapy in Patients With Unresectable Intrahepatic Cholangiocarcinoma—PUMP-2 Trial 翻译：肝动脉灌注泵化疗治疗不可切除肝内胆管癌——PUMP‑2 试验题目：BRUIN CLL-313: Randomized Phase III Trial of Pirtobrutinib Versus Bendamustine Plus Rituximab in Untreated Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma 翻译：BRUIN CLL‑313：吡托布鲁替尼对比苯达莫司汀联合利妥昔单抗治疗初治慢性淋巴细胞白血病/ 小淋巴细胞淋巴瘤的随机Ⅲ期试验题目：Pirtobrutinib Versus Ibrutinib in Treatment-Naïve and Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma 翻译：吡托布鲁替尼对比伊布替尼治疗初治及复发/ 难治性慢性淋巴细胞白血病/ 小淋巴细胞淋巴瘤题目：Extended Endocrine Therapy Following 5 Years of Adjuvant Luteinizing Hormone-Releasing Hormone Agonist in Premenopausal Patients With Node-Positive, Hormone Receptor–Positive Breast Cancer: A Cohort Study 翻译：淋巴结阳性、激素受体阳性绝经前乳腺癌患者接受5 年促黄体生成素释放激素激动剂辅助治疗后的延长内分泌治疗：一项队列研究题目：NCI9673 (Part B): ETCTN Randomized Phase II Study of Nivolumab With or Without Ipilimumab in Refractory, Metastatic Squamous Cell Carcinoma of the Anal Canal 翻译：NCI9673（B部分）：纳武利尤单抗联合或不联合伊匹木单抗治疗难治性转移性肛管鳞状细胞癌的ETCTN 随机Ⅱ期试验 LANCET ONCOLOGY（本周无更新） JOURNAL OF THORACIC ONCOLOGY（本周无更新） JAMA ONCOLOGY 题目：Predictive Role of Circulating Tumor DNA in Stage III Colon Cancer Treated With Celecoxib: A Post Hoc Analysis of the CALGB (Alliance)/SWOG 80702 Phase 3 Randomized Clinical Trial 翻译：循环肿瘤 DNA 在接受塞来昔布治疗的Ⅲ期结肠癌中的预测价值：CALGB（Alliance）/SWOG 80702 Ⅲ期随机临床试验的事后分析题目：Cognitive Impairment and Chemoendocrine vs Endocrine Therapy in Pre- and Postmenopausal Women: A Secondary Analysis of the RxPONDER Randomized Clinical Trial 翻译：绝经前与绝经后女性的认知功能损伤及化疗内分泌治疗对比内分泌治疗：RxPONDER随机临床试验的二次分析题目：Enhancement of Patient-Centered Lung Cancer Screening: The MyLungHealth Randomized Clinical Trial 翻译：以患者为中心的肺癌筛查优化：MyLungHealth 随机临床试验题目：Quadrivalent Human Papillomavirus Vaccine and High-Grade Vulvovaginal Lesions 翻译：四价人乳头瘤病毒疫苗与高级别外阴阴道病变题目：Baseline Fatigue and Severe Toxic Effects in Patients With Cancer Receiving Systemic Therapy 翻译：接受全身治疗的癌症患者基线疲劳程度与严重毒性反应 CANCER RESEARCH 题目：EZH2 Suppression Diversifies Prostate Cancer Lineage Variant Evolution and Lacks Efficacy in Inhibiting Disease Progression 翻译：抑制 EZH2 可增加前列腺癌谱系变异演化多样性，但无法有效抑制疾病进展题目：The Aging Microenvironment Is a Determinant of Immune Exclusion and Metastatic Fate in Pancreatic Cancer 翻译：衰老微环境是胰腺癌免疫排斥与转移命运的决定因素题目：Mitochondrial Transfer Rescues Respiration to Support De Novo Pyrimidine Biosynthesis and Tumor Progression 翻译：线粒体转移可恢复呼吸作用，支持从头嘧啶合成与肿瘤进展题目：Dissection of Gαs and Hedgehog Signaling Cross-talk Reveals Therapeutic Opportunities to Target Hedgehog-Dependent Tumors 翻译：解析 Gαs与Hedgehog 信号通路交互作用，为靶向Hedgehog 依赖性肿瘤提供治疗策略题目：Protumor Macrophage Polarization Mediated by BMP2/4–ACVR1 Signaling Orchestrates an Immunosuppressive Microenvironment during Tumor Initiation 翻译：肿瘤发生阶段，BMP2/4–ACVR1信号介导的促肿瘤巨噬细胞极化构建免疫抑制微环境题目：Tetraspanin 13 Enhances Immune Evasion in Breast Cancer by Promoting MHC-I Degradation 翻译：四次跨膜蛋白 13 通过促进MHC‑I 降解增强乳腺癌免疫逃逸题目：Cancer-Associated Fibroblasts Promote Imatinib Resistance in Gastrointestinal Stromal Tumors through PGK1-Mediated Metabolic Reprogramming 翻译：癌相关成纤维细胞通过 PGK1 介导的代谢重编程促进胃肠道间质瘤对伊马替尼耐药题目：Catalytic Inhibition of p300 Preferentially Targets IRF4 Oncogenic Activity and Tumor Growth in Multiple Myeloma 翻译：p300 催化抑制可优先靶向多发性骨髓瘤中IRF4 致癌活性与肿瘤生长题目：CRISPR-Cas9 Screening Identifies Resistance Mechanisms to KRAS Inhibition in Pancreatic Cancer 翻译：CRISPR‑Cas9 筛选揭示胰腺癌对KRAS 抑制的耐药机制题目：An Extracellular Matrix–Producing Subset of Cancer-Associated Fibroblasts Drives Chemoresistance in Breast Cancer via SRC Activation and G0S2 Upregulation 翻译：一类分泌细胞外基质的癌相关成纤维细胞亚群通过SRC 激活与G0S2 上调驱动乳腺癌化疗耐药题目：Dynamic and Ongoing De Novo L1 Retrotransposition Contributes to Genome Plasticity and Intrapatient Heterogeneity in Ovarian Cancer 翻译：动态且持续的从头 L1 逆转录转座促进卵巢癌基因组可塑性与患者内异质性 CLINICAL CANCER RESEARCH 题目：Palbociclib, Trastuzumab, and Endocrine Therapy in Pretreated HER2-Positive and PAM50 Luminal Advanced Breast Cancer: Randomized Phase II, SOLTI-1303 PATRICIA Trial 翻译：哌柏西利、曲妥珠单抗联合内分泌治疗既往接受过治疗的HER2 阳性、PAM50腔面型晚期乳腺癌：SOLTI‑1303 PATRICIA 随机Ⅱ期临床试验题目：FDG-PET–Based Selective Deescalation of Chemoradiation in Human Papillomavirus–Related Oropharyngeal Squamous Cell Carcinoma: A Multicenter Phase II Trial 翻译：基于 FDG‑PET 选择性降阶梯放化疗治疗人乳头瘤病毒相关口咽鳞状细胞癌：一项多中心Ⅱ期临床试验题目：T-Cell Receptor and Immune Gene Expression Pharmacodynamics for Durvalumab Alone and with Tremelimumab or Bevacizumab in Unresectable Hepatocellular Carcinoma 翻译：度伐利尤单抗单药或联合曲美木单抗 / 贝伐珠单抗治疗不可切除肝细胞癌的T 细胞受体与免疫基因表达药效学研究题目：HBV Reactivation in Patients with Hepatocellular Carcinoma Treated with PD-1/-L1 Antibodies and Concurrent Antiviral Prophylaxis Agents: A Prospective Observational Study 翻译：PD‑1/PD‑L1 抗体联合预防性抗病毒药物治疗肝细胞癌患者的乙肝病毒再激活：一项前瞻性观察性研究题目：Anti–LAG-3 Antibody LBL-007 plus Tislelizumab and Chemotherapy as First-Line Therapy for Advanced Nasopharyngeal Carcinoma: A Multicenter Phase 2 Trial 翻译：抗 LAG‑3 抗体LBL‑007 联合替雷利珠单抗与化疗作为晚期鼻咽癌一线治疗：一项多中心Ⅱ期临床试验题目：Molecular Profiling and Tumor Biomarker Analysis of GOG281/LOGS: A Positive Late-Phase Trial of Trametinib for Recurrent/Persistent Low-Grade Serous Ovarian Carcinoma 翻译：GOG281/LOGS 研究的分子谱与肿瘤生物标志物分析：曲美替尼治疗复发性/ 持续性低级别浆液性卵巢癌的阳性晚期试验题目：Investigating Early Kinetics in Plasma ctDNA and Peripheral T-cell Receptor Repertoire to Predict Treatment Outcomes to PD-1 Inhibitors in Head and Neck Squamous Cell Carcinoma 翻译：血浆 ctDNA 早期动力学与外周T 细胞受体库预测头颈部鳞状细胞癌PD‑1 抑制剂治疗疗效题目：Minimal Residual Disease Enhances Prognostic Stratification beyond Pathologic Response in Resectable Non–Small Cell Lung Cancer 翻译：可切除非小细胞肺癌中，微小残留病可在病理缓解之外进一步提升预后分层效能题目：Improving a Plasma Biomarker Panel for Early Detection of Pancreatic Ductal Adenocarcinoma with Aminopeptidase N (ANPEP) and Polymeric Immunoglobulin Receptor (PIGR) 翻译：联合氨基肽酶 N（ANPEP）与多聚免疫球蛋白受体（PIGR）优化胰腺导管腺癌早期检测血浆生物标志物panel 题目：Germline Pathogenic Variant Prediction Model for Tumor-Only Sequencing Based on Japanese Clinicogenomic Database 翻译：基于日本临床基因组数据库的仅肿瘤测序胚系致病变异预测模型题目：Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity 翻译：TNFR2 上调先于耗竭T 细胞TOX 表达，并抑制抗肿瘤与抗病毒免疫题目：Additive Clinical Utility of Microsatellite Instability and Tumor Mutational Burden to Predict Immune Checkpoint Inhibitor Effectiveness in Metastatic Castration-Resistant Prostate Cancer 翻译：微卫星不稳定性与肿瘤突变负荷在预测转移性去势抵抗性前列腺癌免疫检查点抑制剂疗效中的附加临床价值题目：A Generative Foundation Model for Scalable Cytology Image Synthesis in AI-Powered Diagnostics 翻译：用于 AI 辅助诊断中可规模化细胞学图像合成的生成式基础模型 JOURNAL OF THE NATIONAL CANCER CENTER 题目：Clinicopathologic, genetic and immune cell infiltration analysis of colorectal signet ring cell carcinoma with comparison to conventional adenocarcinoma 翻译：结直肠印戒细胞癌的临床病理、遗传学及免疫细胞浸润分析——并与常规腺癌对比 JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE（本周无更新） 3.内分泌学与代谢 LANCET DIABETES & ENDOCRINOLOGY 题目：Effect of surgical versus conservative management on cardiovascular outcomes in patients with bilateral adrenal tumours and cortisol excess: an international, retrospective cohort study 翻译：手术治疗对比保守治疗对双侧肾上腺肿瘤合并皮质醇增多患者心血管结局的影响：一项国际回顾性队列研究题目：3 months vs 12 months of romosozumab for postmenopausal osteoporosis (LIDA): an open-label, non-inferiority, randomised controlled trial 翻译：罗莫佐单抗治疗绝经后骨质疏松症 3 个月对比12 个月（LIDA）：一项开放标签、非劣效性随机对照试验题目：Temporal changes and genetic susceptibility to type 2 diabetes (1984–2019; HUNT): a longitudinal, population-based study 翻译：2 型糖尿病的时间变化趋势与遗传易感性（1984–2019；HUNT研究）：一项基于人群的纵向研究题目：Efficacy and safety of inclisiran in adolescents with heterozygous familial hypercholesterolaemia (ORION-16): a two-part, randomised, multicentre clinical trial 翻译：英克西兰治疗杂合子家族性高胆固醇血症青少年的有效性与安全性（ORION‑16）：一项两阶段、多中心随机临床试验 DIABETES CARE 题目：The Effect of Midpregnancy Screening for Gestational Diabetes Mellitus on Pregnancy Outcomes: The TESGO Randomized Controlled Trial 翻译：妊娠中期妊娠期糖尿病筛查对妊娠结局的影响：TESGO随机对照试验题目：Generalizability of Progression Risk in the TN-10 Trial to a European Population With or Without a First-Degree Relative With Type 1 Diabetes 翻译：TN-10 研究中进展风险在有无1 型糖尿病一级亲属的欧洲人群中的外推性题目：Safety and Feasibility of a Fully Automated Insulin Delivery System: FCL@Home, a Multicenter Randomized Clinical Trial in Individuals With Type 1 Diabetes 翻译：全自动胰岛素输注系统的安全性与可行性：FCL@Home——一项针对1 型糖尿病患者的多中心随机临床试验题目：Impact of Maternal Diabetes in Pregnancy on Newborn IgG Antibody Repertoire and Infection Risk in the First 6 Months of Life 翻译：孕期母体糖尿病对新生儿 IgG 抗体谱及出生后6 个月内感染风险的影响题目：MiniMed 780G Advanced Hybrid Closed-Loop System Use During Days Without User-Initiated Boluses 翻译：无用户主动推注期间 MiniMed 780G 高级混合闭环系统的使用情况题目：Metabolic Factors Modulating the Connection Between Diabetes and Pulmonary Alterations 翻译：调控糖尿病与肺部改变之间关联的代谢因素题目：Interoceptive Awareness Moderates the Relationship Between Hypoglycemia Exposure and Symptom Recognition in Adults With Type 1 Diabetes 翻译：内感受感知调节 1 型糖尿病成人低血糖暴露与症状识别之间的关系题目：Associations of Moderate-to-Vigorous Physical Activity Timing With Type 2 Diabetes Incidence in UK Biobank and Prevalent Glycemic Measures in NHANES 翻译：英国生物银行中中高强度体力活动时间与2 型糖尿病发病风险的关联及NHANES 中血糖相关指标的横断面分析题目：Soluble Urokinase Plasminogen Activator Receptor (suPAR) Mediates the Impact of Diabetes on Adverse Outcomes in Coronary Artery Disease 翻译：可溶性尿激酶型纤溶酶原激活物受体（suPAR）介导糖尿病对冠心病不良结局的影响题目：Gout-Related Medication Use After Initiating Sodium–Glucose Cotransporter 2 Inhibitors in Patients With Gout and Type 2 Diabetes: Population-Based Target Trial Emulation Studies 翻译：痛风合并 2 型糖尿病患者启动钠- 葡萄糖协同转运蛋白2 抑制剂后痛风相关药物使用：基于人群的目标试验模拟研究题目：A Comparison of Diet and Exercise During Pregnancy in Women With and Without Type 1 Diabetes Followed in the Environmental Determinants of Islet Autoimmunity (ENDIA) Study 翻译：胰岛自身免疫环境决定因素（ENDIA）研究中1 型糖尿病与非1 型糖尿病孕妇孕期饮食与运动的比较题目：Chronic Kidney Disease and Risk of Diabetic Ketoacidosis in Type 1 Diabetes 翻译：慢性肾脏病与 1 型糖尿病糖尿病酮症酸中毒风险的关系题目：Assessing Time Below Range as a Predictor of Severe Hypoglycemia: Insights From Six Clinical Trials 翻译：评估血糖低于范围时间作为严重低血糖的预测因子：六项临床试验的启示题目：Global, Regional, and National Estimates of Undiagnosed Diabetes in Adults: Findings From the 2025 IDF Diabetes Atlas 翻译：全球、区域及国家层面成人未确诊糖尿病估计：2025年IDF 糖尿病图谱结果题目：Sex Hormones and Cardiovascular Risk in Type 2 Diabetes: Cohort Study of the Look AHEAD Trial 翻译：2 型糖尿病中性激素与心血管风险：Look AHEAD 试验的队列研究题目：Rapid Postpartum Progression to Diabetes Following Early Antenatal Prediabetes: Evidence From a Multiethnic New Zealand Cohort 翻译：孕期早期 prediabetes 后产后快速进展为糖尿病：新西兰多种族队列研究证据 4.心血管病学 CIRCULATION 题目：Hypertensive Disorders of Pregnancy and Premature Cardiovascular Disease in a Diverse Cohort of Young US Women 翻译：妊娠期高血压疾病与美国多种族年轻女性早发性心血管疾病的关系题目：Polycystic Ovarian Syndrome and the Long-Term Risk of Arrhythmias 翻译：多囊卵巢综合征与心律失常长期发病风险题目：Association of Statin Discontinuation in Pregnancy With Maternal Cardiovascular Health and Birth Outcomes: A Nationwide Cohort Study 翻译：孕期停用他汀类药物与母体心血管健康及分娩结局的关联：一项全国性队列研究题目：Breast Cancer Reveals Latent BMPR2-Related Susceptibility to Pulmonary Hypertension 翻译：乳腺癌揭示潜在的BMPR2相关肺动脉高压易感性 EUROPEAN HEART JOURNAL 题目：Catheter ablation in congenital heart diseases: a French nationwide study 翻译：先天性心脏病的导管消融术：一项法国全国性研究题目：Arrhythmias in congenitally corrected transposition of the great arteries: an international study 翻译：先天性矫正型大动脉转位中的心律失常：一项国际研究题目：Early outcomes of children with univentricular circulation undergoing Fontan surgery: the EuroFontan registry 翻译：单心室循环患儿接受 Fontan 手术的早期结局：EuroFontan注册登记研究题目：Adults with Fontan circulation: prognostic value of exercise pulmonary vascular resistance index 翻译：Fontan 循环成人患者：运动肺血管阻力指数的预后价值 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 题目：Menopausal Status Associated With Docetaxel-Induced Vascular Dysfunction in Breast Cancer Patients 翻译：绝经状态与乳腺癌患者多西他赛诱导的血管功能障碍相关题目：Sex-Specific Microaxial Flow Pump Use and Outcomes in Infarct-Related Cardiogenic Shock in the DanGer Shock Trial 翻译：DanGer 休克研究：梗死相关性心源性休克中微型轴流泵的使用及结局存在性别差异 5.胃肠肝病学 LANCET GASTROENTEROLOGY & HEPATOLOGY（本周无更新） JOURNAL OF HEPATOLOGY 题目：Genetic and non-genetic drivers of histological progression and regression in MASLD 翻译：MASLD 组织学进展与逆转的遗传及非遗传驱动因素题目：HBx-induced HSPB1 is a potential therapeutic target owing to its modulation of HBV cccDNA and hepatic immune responses 翻译：HBx 诱导的HSPB1 通过调控HBV cccDNA 与肝脏免疫反应成为潜在治疗靶点题目：Safety and efficacy of REP 2139-Mg in patients with HDV-related advanced liver disease in an international compassionate access program 翻译：国际同情用药项目中 REP 2139-Mg 治疗HDV 相关晚期肝病的安全性与有效性题目：Refining the Baveno VII criteria for clinically significant portal hypertension: An individual patient data meta-analysis 翻译：优化具有临床意义门静脉高压的 Baveno VII 标准：一项个体患者数据荟萃分析题目：Setd4-expressing cells drive regenerative recovery in chronic liver injury 翻译：表达 Setd4 的细胞介导慢性肝损伤的再生修复题目：Strategies to address non-proportional hazards between survival curves - Lessons from phase III trials in hepatocellular carcinoma 翻译：处理生存曲线间非比例风险的策略——来自肝细胞癌Ⅲ期试验的启示题目：HES V2.0 validation and performance compared to GALAD and ASAP in the HEDS cohort 翻译：HEDS 队列中HES V2.0 与GALAD、ASAP的对比验证及性能评估题目：Genetically engineered pig-to-human liver xenotransplantation 翻译：基因工程猪 - 人肝脏异种移植题目：PARG inhibition halts cholangiocarcinoma progression via the Hippo pathway and enhances response to chemotherapy and immunotherapy 翻译：PARG 抑制通过Hippo 通路阻断胆管癌进展并增强化疗与免疫治疗应答题目：Transcriptomic and epigenetic mechanisms controlling cholangiocyte transdifferentiation into hepatocytes 翻译：调控胆管细胞转分化为肝细胞的转录组与表观遗传机制 GUT 题目：MTFP1 drives pancreatic cancer liver metastatic colonisation by regulating mitochondrial metabolism reprogramming 翻译：MTFP1 通过调控线粒体代谢重编程驱动胰腺癌肝转移定植题目：Oleic acid promotes lung injury in hypertriglyceridaemia-associated acute pancreatitis via the PIEZO1/NR4A1/CPT1A axis impairing endothelial fatty acid oxidation 翻译：油酸通过 PIEZO1/NR4A1/CPT1A 轴损伤内皮细胞脂肪酸氧化，加重高甘油三酯血症相关性急性胰腺炎的肺损伤题目：E-cadherin loss in Cd44-positive gastric cells initiates diffuse gastric cancer in a murine model 翻译：小鼠模型中 Cd44 阳性胃上皮细胞E‑钙黏蛋白缺失可启动弥漫型胃癌发生题目：Spatial profiling of patient-matched HER2 positive gastric cancer reveals resistance mechanisms to targeted therapy 翻译：患者配对 HER2 阳性胃癌的空间组学分析揭示靶向治疗耐药机制 GASTROENTEROLOGY 题目：Gastric Organoid-Based Ectopic and Orthotopic In Vivo CRISPR Screening for Tumor Suppressors in Gastric Cancer 翻译：基于胃类器官的异位及原位体内 CRISPR 筛选胃癌肿瘤抑制基因题目：Postoperative Ileum Transcriptomics Implicate Sex-Biased Mechanisms in Crohn’s Disease Recurrence 翻译：术后回肠转录组学提示克罗恩病复发中存在性别差异机制题目：Fecal Detection of Calprotectin Subunits Links Inflammatory Bowel Disease Activity With Chronicity of Intestinal Inflammation 翻译：粪便钙卫蛋白亚基检测将炎症性肠病活动度与肠道炎症慢性化相关联题目：The Gut Microbiome at the Onset of Inflammatory Bowel Disease: A Systematic Review and Unified Bioinformatic Synthesis 翻译：炎症性肠病发病时的肠道微生物组：一项系统评价与统一生物信息学整合分析题目：Mutational Landscape of Colorectal Tumors From Individuals With Unexplained Adenomatous or Serrated Colorectal Polyposis 翻译：原因不明腺瘤性或锯齿状结肠息肉病患者结直肠肿瘤的突变图谱题目：Clusterin Drives Fiber Endocytosis by Mesothelial Cells to Resolve Liver Fibrosis 翻译：簇蛋白驱动间皮细胞摄取纤维以缓解肝纤维化题目：Endoscopic Ultrasound-Guided Choledochoduodenostomy vs Endoscopic Retrograde Cholangiopancreatography in Malignant Distal Biliary Obstruction to Prevent Postprocedural Pancreatitis: A Randomized Trial 翻译：内镜超声引导下胆管十二指肠吻合术 vs 内镜逆行胰胆管造影用于恶性远端胆道梗阻以预防术后胰腺炎：一项随机试验题目：Utility of Serum Biomarkers in Addition to Ultrasound for Early Detection of Hepatocellular Carcinoma in High-Risk Patients: A Randomized Controlled Trial 翻译：高危患者中血清生物标志物联合超声用于肝细胞癌早期检测的价值：一项随机对照试验题目：Changes in Liver Disease Etiology Support a Lower Alpha-Fetoprotein Threshold for Hepatocellular Carcinoma Screening 翻译：肝病病因变化支持降低甲胎蛋白阈值用于肝细胞癌筛查 6.呼吸病学 LANCET RESPIRATORY MEDICINE（本周无更新） EUROPEAN RESPIRATORY JOURNAL（本周无更新） 7.感染与微生物 LANCET INFECTIOUS DISEASES（本周无更新） LANCET MICROBE（本周无更新） NATURE MICROBIOLOGY 题目：Gut microbial ammonia enhances colonic acetylcholine levels to regulate intestinal motility 翻译：肠道微生物产生的氨升高结肠乙酰胆碱水平并调节肠道动力题目：Conserved CD4+ T cell staphylococcal and streptococcal epitopes enable broad-acting vaccines in mice 翻译：保守的 CD4⁺T 细胞葡萄球菌与链球菌表位可在小鼠中实现广谱疫苗作用题目：Longitudinal plasma metabolomics reveals a role for taurine in asymptomatic malaria and seasonal persistence 翻译：纵向血浆代谢组学揭示牛磺酸在无症状疟疾与季节性持续感染中的作用题目：Candida aurisvacuolar calcium pump mediates fluconazole efflux and resistance evolution 翻译：耳念珠菌液泡钙泵介导氟康唑外排与耐药进化题目：Human immunodeficiency virus-associated gut microbiome impacts systemic immunodeficiency and susceptibility to opportunistic gut infection 翻译：人类免疫缺陷病毒相关肠道微生物组影响全身性免疫缺陷及机会性肠道感染易感性 MICROBIOME 题目：Comparative analysis of rumen metagenomes with dietary supplementation of 3-nitrooxypropanol revealed divergent modes of action in hydrogen metabolism and reductant pathways between beef and dairy cattle 翻译：日粮添加 3‑硝基氧丙醇的瘤胃宏基因组比较分析揭示肉牛与奶牛在氢代谢及还原通路中存在不同作用模式题目：Microbiota-derived propionate suppresses Salmonella virulence gene expression via LuxS quorum sensing 翻译：微生物组来源的丙酸通过 LuxS 群体感应抑制沙门菌毒力基因表达题目：Association between the gut microbiome and plasma metabolites linked to vocalization-based temperament in Merino sheep 翻译：美利奴绵羊肠道微生物组与血浆代谢物的关联和基于发声的气质相关题目：Cross-kingdom genomic variation in chicken gut microbiomes: insights from China’s diverse local breeds 翻译：鸡肠道微生物组的跨界基因组变异：来自中国多样地方品种的启示 JOURNAL OF INFECTION（本周无更新） 8.公共卫生和流行病学 LANCET PUBLIC HEALTH（本周无更新） LANCET GLOBAL HEALTH 题目：Global estimates of tuberculosis incidence during pregnancy and postpartum: a rapid review and modelling analysis 翻译：全球孕期及产后期结核病发病率估计：一项快速综述与模型分析题目：Characterising progression and regression patterns across the spectrum of tuberculosis: a multistate modelling approach 翻译：结核病全疾病谱进展与转归模式特征：多状态模型研究题目：Avoidable deaths through the primary prevention, early detection, and curative treatment of cancer worldwide: a population-based study 翻译：全球通过癌症一级预防、早期筛查与根治性治疗可避免的死亡：一项基于人群的研究题目：Effective cataract surgical coverage in adults aged 50 years and older: empirical estimates from population-based surveys in 68 countries and modelled estimates for 2000–30 翻译：50 岁及以上成人有效白内障手术覆盖率：来自68 国人群调查的实证估计及2000–2030年模型预测题目：Early assessment of maternal bleeding: development and validation of a prognostic model predicting death and near miss 翻译：孕产妇出血早期评估：预测死亡与危重不良事件预后模型的建立与验证题目：Low-dose aspirin for preventing intrauterine growth restriction and pre-eclampsia in sickle cell pregnancy in Nigeria (PIPSICKLE): a randomised controlled trial 翻译：尼日利亚镰状细胞病孕妇使用小剂量阿司匹林预防胎儿生长受限与子痫前期（PIPSICKLE）：一项随机对照试验题目：Evaluation of fluorometholone as adjunctive medical therapy for trachomatous trichiasis surgery (FLAME): a parallel, double-blind, randomised controlled field trial in the Jimma Zone, Ethiopia 翻译：氟米龙作为沙眼性倒睫手术辅助药物治疗的评估（FLAME）：埃塞俄比亚吉马地区平行、双盲、随机对照现场试验题目：Effectiveness of behavioural tobacco cessation interventions with and without pharmacotherapy among people living with HIV in Viet Nam: a three-arm pragmatic randomised controlled trial 翻译：越南 HIV 感染者中联合或不联合药物治疗的行为戒烟干预效果：三臂实用性随机对照试验题目：Prevalence and outcomes of intrinsic capacity impairments assessed using the WHO Integrated Care for Older People (ICOPE) framework in The Gambia, South Africa, and Zimbabwe: a cross-sectional study 翻译：采用 WHO 老年人综合照护（ICOPE）框架评估冈比亚、南非与津巴布韦内在能力受损的患病率与结局：一项横断面研究题目：Measuring the impact of global research and development investment in product development partnerships: a case study on return on investment in antimalarial drug development 翻译：评估全球研发投入对产品开发伙伴关系的影响：抗疟药物研发投资回报案例分析题目：Cost and cost-effectiveness of ivermectin mass drug administration for malaria control in Kwale county, Kenya: a modelling analysis of a cluster-randomised trial 翻译：肯尼亚夸勒县伊维菌素大规模给药用于疟疾防控的成本及成本效果：整群随机试验模型分析 9.内科学 JAMA INTERNAL MEDICINE（本周无更新） ANNALS OF INTERNAL MEDICINE 题目：Effectiveness and Safety of Statins in Type 2 Diabetes According to Baseline Cardiovascular Risk 翻译：根据基线心血管风险分层分析他汀类药物在2 型糖尿病中的有效性与安全性题目：Once-Weekly Oral Islatravir Plus Lenacapavir Versus Daily Oral Bictegravir, Emtricitabine, and Tenofovir Alafenamide in Persons With HIV-1 翻译：每周一次口服伊司拉韦 + 来那卡帕韦对比每日口服比克替拉韦/ 恩曲他滨/ 丙酚替诺福韦治疗HIV‑1 感染者题目：Integrating Methadone Services Into Primary Care in Ukraine: Two-Year Outcomes From a Randomized Trial 翻译：将美沙酮服务整合至乌克兰初级保健：一项随机试验的2 年结局题目：Diagnostic Follow-up of Positive Results on Low-Dose Computed Tomography Screening in the Medicare Population 翻译：美国医保人群低剂量 CT 筛查阳性结果后的诊断随访题目：Eligibility and Prognostic Performance of Smoking Duration–Based Versus Pack-Year–Based U.S. National Lung Cancer Screening Criteria Across Racial and Ethnic Groups 翻译：美国国家肺癌筛查标准中：基于吸烟年限vs 基于包年的适用人群与预后表现在不同种族/ 族裔间的对比题目：The Incubation Periods of Mpox Virus Clade Ib 翻译：猴痘病毒 Ib 分支的潜伏期 10.血液学 LANCET HAEMATOLOGY（本周无更新） 11.牙科与口腔外科 JOURNAL OF CLINICAL PERIODONTOLOGY（本周无更新）

100 项与甲磺酸伊马替尼相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D01441	甲磺酸伊马替尼	L01XE01	DB00619

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
加速期费城染色体阳性慢性粒细胞白血病	美国	Shorla Pharma Ltd.	2024-11-22
急变期费城染色体阳性慢性粒细胞白血病	美国	Shorla Pharma Ltd.	2024-11-22
慢性期费城染色体阳性慢性粒细胞白血病	美国	Shorla Pharma Ltd.	2024-11-22
转移性胃肠道间质瘤	欧盟	Accord Healthcare SLU	2013-06-30
转移性胃肠道间质瘤	冰岛	Accord Healthcare SLU	2013-06-30
转移性胃肠道间质瘤	列支敦士登	Accord Healthcare SLU	2013-06-30
转移性胃肠道间质瘤	挪威	Accord Healthcare SLU	2013-06-30
骨髓增生性疾病	欧盟	Teva Pharmaceuticals Europe BV	2013-01-07
骨髓增生性疾病	冰岛	Teva Pharmaceuticals Europe BV	2013-01-07
骨髓增生性疾病	列支敦士登	Teva Pharmaceuticals Europe BV	2013-01-07
骨髓增生性疾病	挪威	Teva Pharmaceuticals Europe BV	2013-01-07
Ph样急性淋巴细胞白血病	欧盟	Teva Pharmaceuticals Europe BV	2013-01-07
Ph样急性淋巴细胞白血病	冰岛	Teva Pharmaceuticals Europe BV	2013-01-07
Ph样急性淋巴细胞白血病	列支敦士登	Teva Pharmaceuticals Europe BV	2013-01-07
Ph样急性淋巴细胞白血病	挪威	Teva Pharmaceuticals Europe BV	2013-01-07
费城染色体阳性白血病	欧盟	Teva Pharmaceuticals Europe BV	2013-01-07
费城染色体阳性白血病	冰岛	Teva Pharmaceuticals Europe BV	2013-01-07
费城染色体阳性白血病	列支敦士登	Teva Pharmaceuticals Europe BV	2013-01-07
费城染色体阳性白血病	挪威	Teva Pharmaceuticals Europe BV	2013-01-07
急性淋巴细胞白血病	美国	Novartis Pharmaceuticals Corp.	2006-10-19

未上市

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
肺心病	临床3期	荷兰	Jade Biosciences, Inc.	2022-02-16
混合表型急性白血病	临床3期	美国	The Children's Oncology Group Foundation, Inc.	2017-08-08
混合表型急性白血病	临床3期	澳大利亚	The Children's Oncology Group Foundation, Inc.	2017-08-08
混合表型急性白血病	临床3期	奥地利	The Children's Oncology Group Foundation, Inc.	2017-08-08
混合表型急性白血病	临床3期	比利时	The Children's Oncology Group Foundation, Inc.	2017-08-08
混合表型急性白血病	临床3期	加拿大	The Children's Oncology Group Foundation, Inc.	2017-08-08
混合表型急性白血病	临床3期	智利	The Children's Oncology Group Foundation, Inc.	2017-08-08
混合表型急性白血病	临床3期	捷克	The Children's Oncology Group Foundation, Inc.	2017-08-08
混合表型急性白血病	临床3期	芬兰	The Children's Oncology Group Foundation, Inc.	2017-08-08
混合表型急性白血病	临床3期	法国	The Children's Oncology Group Foundation, Inc.	2017-08-08

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分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03997903 (IMPACT \| IMPACT SCA, CTgov)	临床1/2期	疼痛 \| 脊髓小脑性共济失调 \| 急性疼痛 ... 更多	7	Imatinib Mesylate	壓積夢蓋壓鏇簾鑰獵遞 = 蓋築網範廠夢製壓糧衊鏇廠襯製製醖餘築繭蓋 (憲願齋製製獵醖觸觸窪, 獵夢淵獵憲鏇構鹽憲鹹 ~ 襯鹽觸簾獵糧觸糧範壓) 更多	-	2026-01-29
NCT03654768 (CTgov)	临床2期	慢性期慢性髓性白血病	81	dasatinib+nilotinib+imatinib+bosutinib (Single Agent TKI)	淵艱觸鬱簾築築獵蓋構 = 廠衊襯積遞襯獵膚憲壓齋襯選顧蓋顧構繭齋願 (願遞餘廠構鏇繭憲積顧, 獵齋鹽衊鬱製蓋構衊憲 ~ 淵鬱築鬱範醖築糧鏇衊) 更多	-	2025-12-18
				Ruxolitinib (TKI + Ruxolitinib)	淵艱觸鬱簾築築獵蓋構 = 壓範壓顧築餘繭夢淵範齋襯選顧蓋顧構繭齋願 (願遞餘廠構鏇繭憲積顧, 餘繭壓願構構獵簾廠齋 ~ 艱選積繭醖鹹選繭蓋鹽) 更多
ASH2025	N/A	特发性肥大细胞活化综合征	28	Imatinib	夢糧鹹選獵膚蓋觸鏇艱(構蓋廠壓衊憲鹽網衊窪) = 構遞積壓蓋窪憲顧艱築夢獵壓網憲構築鬱窪蓋 (膚鏇鹹積蓋鑰餘蓋選鹽 ) 更多	积极	2025-12-06
ASH2025	N/A	慢性期慢性髓性白血病	530	imatinib	繭齋壓鹹蓋範願鹽鏇醖(積構窪壓遞觸蓋鑰淵鏇) = 願鏇獵衊艱糧糧鬱襯餘艱積顧製壓鏇觸顧憲廠 (鏇顧構鬱鏇鏇淵獵積鑰 ) 更多	积极	2025-12-06
				nilotinib	繭齋壓鹹蓋範願鹽鏇醖(積構窪壓遞觸蓋鑰淵鏇) = 製齋襯繭膚構窪淵糧獵艱積顧製壓鏇觸顧憲廠 (鏇顧構鬱鏇鏇淵獵積鑰 ) 更多
ASH2025	N/A	-	212	Intensive Chemotherapy (IC)	淵廠築製鑰鹹膚鹽餘艱(鹽獵製鑰憲積鹹繭獵顧) = 襯齋獵鏇醖糧夢鬱齋構醖構積餘鑰繭構簾鬱製 (獵淵糧獵獵廠夢壓選顧 ) 更多	积极	2025-12-06
				Intensive Chemotherapy + Tyrosine Kinase Inhibitor (IC + TKI)	淵廠築製鑰鹹膚鹽餘艱(鹽獵製鑰憲積鹹繭獵顧) = 餘範構淵觸選繭鑰齋艱醖構積餘鑰繭構簾鬱製 (獵淵糧獵獵廠夢壓選顧 ) 更多
ASH2025	N/A	ANKRD26 pathogenic variants	27	Venetoclax combined with cladribine, idarubicin, and cytarabine	壓獵獵蓋製糧鬱築獵遞(製鏇膚築蓋餘繭簾觸積) = 膚範鑰觸鹹糧網築築製淵鹹蓋鏇簾夢艱簾艱繭 (選選窪遞壓蓋壓獵糧窪 ) 更多	积极	2025-12-06
KISS (ASH2025)	临床2期	慢性期慢性髓性白血病一线	96	Imatinib	網齋齋鬱糧齋淵糧鏇鹽(觸遞網壓衊夢衊夢繭蓋) = 鑰蓋觸窪鏇糧網淵願淵鏇鏇築網鑰鏇夢齋積顧 (襯廠積醖淵願鹹憲獵顧, 73 ~ 94) 更多	积极	2025-12-06
ASH2025	N/A	慢性粒细胞性白血病一线	88	Imatinib	築遞廠觸襯選繭鑰窪齋(夢積繭鑰蓋餘遞積網夢) = 艱製餘餘鏇廠壓膚衊願醖構顧積鬱鏇範廠觸鏇 (鹽鹽膚艱壓鹹衊簾窪獵 ) 更多	积极	2025-12-06
ASH2025	N/A	慢性粒细胞性白血病	54	Imatinib	糧餘廠構鹹廠衊壓夢簾(壓繭範夢窪鑰顧顧醖蓋) = 廠積築鏇艱範憲鏇鑰衊築齋蓋繭醖餘鹽構築網 (鏇積蓋衊繭淵襯窪襯蓋 ) 更多	积极	2025-12-06
				Second-generation TKIs	鹽淵願鹹顧餘廠簾鏇艱(衊構範鏇鏇淵網鹽餘範) = 鑰製齋窪遞廠廠艱窪憲獵糧顧獵鏇願齋壓衊繭 (願憲淵膚鏇獵顧築餘廠 ) 更多
ASH2025	N/A	费城染色体阳性急性淋巴细胞白血病	958	imatinib	淵範築築簾鏇鹹醖廠築(齋壓憲願憲壓簾蓋鹽壓) = 願憲廠觸艱窪壓淵齋廠淵願膚積鏇鏇廠糧襯築 (夢鏇積築壓齋觸觸窪鹽 ) 更多	积极	2025-12-06
				dasatinib	淵範築築簾鏇鹹醖廠築(齋壓憲願憲壓簾蓋鹽壓) = 壓範範範繭簾膚鑰積顧淵願膚積鏇鏇廠糧襯築 (夢鏇積築壓齋觸觸窪鹽 ) 更多