尿促卵泡素(Urofollitropin (Serono)) - 药物靶点：FSHR_在研适应症：女性不育伴无排卵_专利_临床

概要

基本信息

药物类型

激素

别名

Fertinex、Fertinorm HP、Follitropin human

+ [7]

靶点

FSHR

作用方式

激动剂

作用机制

FSHR激动剂(卵泡刺激素受体激动剂)

治疗领域

泌尿生殖系统疾病

在研适应症

女性不育伴无排卵

非在研适应症-

原研机构

Merck Serono SA

在研机构

香港辉凌制药有限公司北京代表处Ferring GmbHFerring Holding SA

+ [1]

非在研机构

Ferring Pharmaceuticals SA

IBSA Institut Biochimique SA

EMD Serono, Inc.

最高研发阶段临床3期

首次获批日期

美国 (1986-09-18),

不孕

最高研发阶段(中国)临床3期

特殊审评孤儿药 (美国)

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结构/序列

Sequence Code 3246α

Sequence Code 3253α

关联

19

项与尿促卵泡素相关的临床试验

NCT05362799

/ Unknown status临床4期IIT

Different Induction Protocols in PCOS After Clomiphene Citrate Failed Pregnancy in Non-IVF Cycles

The aim of this study will be to compare between 4 different induction protocols in women who:
Failed to achieve ovulation after clomiphene citrate treatment at a dose of 150mg daily (if the patient can tolerate this dose) for 5 days for 3 cycles or only 100 mg daily for the same duration (if she can't tolerate higher dose)
Failed to achieve pregnancy after 3 cycles of ultrasound indicated ovulation with clomiphene citrate treatment at a dose of 100mg or 150mg daily.
All induction protocols will be carried out in non-IVF cycles, and continued for 3 cycles or until pregnancy whichever will be earlier.

开始日期2022-06-01

申办/合作机构

Menoufia University

EUCTR2016-004034-14-IT

/ Unknown status临床2/3期IIT

Randomized controlled phase IIb-III clinical trial to assess the effectiveness of different regimens with u-FSH in the infertile male - UFO – UROFOLLITROPIN IN OLIGOZOOSPERMIA

开始日期2018-10-11

申办/合作机构-

NCT02544191

/ Unknown status临床2期IIT

GnRHa Combined With hCG and hMG for Treatment of Patients With Non-obstructive Azoospermia: A Single-center Prospective Study in China

Preliminary reports showed that hormonal treatment may improve the chance of retrieving viable testicular sperm from men with NOA. It was generally believed that gonadotrophin treatment would be ineffective in the presence of high plasma levels of endogenous gonadotrophin.The purpose of this study is to determine whether GnRHa(gonadotropin-releasing hormone agonist) combined with hCG(human chorionic gonadotropin) and hMG(human menopausal gonadotropin) are effective in the treatment of non-obstructive azoospermia.

开始日期2015-12-01

申办/合作机构

南京大学医学院附属金陵医院

100 项与尿促卵泡素相关的临床结果

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100 项与尿促卵泡素相关的转化医学

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100 项与尿促卵泡素相关的专利（医药）

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116

项与尿促卵泡素相关的文献（医药）

2021-09-01·European Journal of Obstetrics & Gynecology and Reproductive Biology4区 · 医学

YouTube as a source of information on gonadotropin self-injections

4区 · 医学

Article

作者: Seçilmiş, Özlem ; Çintesun, Ersin ; Çintesun, Feyza Nur İncesu

OBJECTIVETo investigate the comprehensiveness, quality, and reliability of YouTube videos that target teaching patients gonadotropin self-injections.STUDY DESIGNVideos demonstrating gonadotropin self-injections were searched using the keywords "Gonal-f injection," "Puregon injection," "Menapur injection," "Merional injection," "Fostimon injection," and "Menagon injection," on December 20th, 2020. The videos were divided into two categories as including "useful information" and "misleading information" by two physicians. A 5-point global quality scale (GQS) and 5-point modified DISCERN scale were used for the assessments of quality and reliability, respectively.RESULTSAmong 110 videos, 90 (81.8%) were found to include useful information and 20 (18.2%) were found to give misleading information. The kappa statistic for inter-observer agreement was 0.817 (p < 0.001). Useful videos were the most comprehensive and had the highest reliability and quality scores. We found that all videos uploaded by universities or professional organizations included useful information. However, there was no significant difference between useful and misleading videos regarding audience interaction analysis parameters (p > 0.05). On the other hand, mean reliability, GQS, and comprehensiveness scores were higher in the useful information group than in the other group. As the subgroup analysis was performed by source, patient opinion videos had lower reliability, comprehensiveness, and GQS scores than videos created by other sources (p < 0.001).CONCLUSIONOur analysis revealed that there were a significant number of English-language YouTube videos, with high quality, rich content, and reliability that could be sources of information on the accurate technique of gonadotropin self-injections. However, some misleading information videos may lead to negative outcomes. Therefore, physicians should ensure that online sources are comprehensive and reliable for the use of their patients with infertility. Also, YouTube health videos should be checked for both reliability and ethical standards.

2020-01-01·April-2020

Consequences of twinning induction to Noemi ewes by a recombinant human follicle-stimulating hormone compared with pituitary-derived porcine follicle-stimulating hormone on follicular dynamics, maternal biochemical attributes, and neonatal traits

Article

作者: Ateah, Mohamed A ; El-Deen, Mohamed Ahmed Shehab ; El-Dawas, Abdulrahman O ; Zeitoun, Moustafa Mohamed

Aim: The aim of this study was to investigate the effectiveness of using recombinant human follicle-stimulating hormone (FSH) compared with pituitary-derived porcine FSH given as one dose or multiple doses on the neonatal traits, follicular dynamics, and maternal blood biochemical constituents in Noemi ewes. Materials and Methods: A 3×2 factorial arrangement was designed utilizing 60 adults Noemi ewes to test the effects of using two sources of FSH (human vs. porcine) in addition to control, either given as a single total dose or six descending doses to provoke twinning. Six treatments (T) were tested (n=10 ewes/T). C1 and C6 served as control ewes given saline as one dose and six doses, respectively; H1 and H6 ewes were given human FSH as one and six doses; and P1 and P6 ewes were given porcine FSH similar to the above treatments. Saline and/or FSH administration were administered at days 8, 9, and 10 of the 10-day controlled internal drug release (CIDR) implant. At CIDR removal, fertile rams were used for natural mating. Blood samples for the assessment of serum metabolites were collected. Results: Twinning increased in FSH-treated ewes than control. However, giving FSH of either source as a single dose resulted in a higher incidence of stillbirths. Pregnancy rates were 30, 40, 50, 60, 70, and 80% in C1, C6, P1, P6, H1, and H6, respectively. Respective percent of ewes delivering twins/multiple birth was 0, 0, 80, 66.7, 71.4, and 87.5%. FSH of human source was more efficient for folliculogenesis than porcine FSH. Administration of FSH increased blood cholesterol, decreased high-density lipoprotein; however, low-density lipoprotein levels were not different than control. Moreover, an interaction (p<0.05) exists between source and type of FSH administration on blood glucose. Six doses of FSH elevated blood protein. Blood albumin decreased by porcine-FSH but not affected by human-FSH. Blood globulins were not different due to source of FSH, whereas giving FSH as six doses increased globulins than in single-dose protocol. Contrariwise, an interaction was found between source and type of FSH administration on elevating the activity of alanine aminotransferase and reducing the activity of aspartate aminotransferase. Conclusion: Administration of human FSH at 180 IU in six descending doses resulted in the best neonatal outcomes and maternal health in Noemi ewes.

2018-02-01·Urologia Journal

Effectiveness of highly purified urofollitropin treatment in patients with idiopathic azoospermia before testicular sperm extraction

Article

作者: Natali, Alessandro ; Carini, Marco ; Capece, Marco ; Morgia, Giuseppe ; Falcone, Marco ; Timpano, Massimiliano ; Della Camera, Pier Andrea ; Serni, Sergio ; Morselli, Simone ; Russo, Giorgio I. ; Gacci, Mauro ; Tasso, Giovanni ; Cito, Gianmartin ; Minervini, Andrea ; Cocci, Andrea ; Morelli, Girolamo

Introduction: Recent evidences demonstrated that male factor alone is responsible for about 30% cases of infertility. Human follicle-stimulating hormone (hFSH) has been introduced to increase sperm concentration, spermatogonial population, or both natural or assisted pregnancy rates (PRs) in oligozoospermic subjects with normal concentrations of gonadotropins. Methods: Fifty infertile men affected by idiopathic azoospermia were enrolled in this study, after undergoing medical history, physical and clinical examination, baseline semen parameters and hormonal plasma concentrations. Inclusion criteria were infertility for at least 2 years, idiopathic azoospermia, FSH <12 mIU/ml. Twenty-five patients were allocated to treatment with hFSH three times/week per 3 months (Fostimon), and 25 patients underwent just testicular sperm extraction (TESE) without medical treatment. All patients underwent, after 3 months, assisted reproduction techniques (ARTs) with TESE. The primary outcome was represented by the differences in the sperm retrieval rate (SRR) between groups, while the secondary outcomes were the differences in PR and fertilization rate (FR). Results: We observed a PR of 15% (3/25) and 28% (7/25) in control and treated group, respectively. SRR after medical treatment and ART was 24% (6/25), while in the control group was 12.5% (2/25). The sperm in the ejaculate of five patients (20%) after medical treatment exhibited a mean concentration of 0.9 million/ml and a mean motility of 12%. The FR was significantly greater in the treatment group with respect to the control group, 30% and 20%, respectively. Conclusions: FSH treatment showed greater efficacy rather than control by increasing the rate of PR and FR in azoospermic patients who underwent TESE.

100 项与尿促卵泡素相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D06269	尿促卵泡素	G03GA04	DB00094

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
女性不育伴无排卵	临床3期	中国	Ferring GmbH	2013-10-17
女性不育伴无排卵	临床3期	中国	Ferring Holding SA	2013-10-17
女性不育伴无排卵	临床3期	中国	香港辉凌制药有限公司北京代表处	2013-10-17
女性不育伴无排卵	临床3期	中国	Ferring Arzneimittel Gmbh	2013-10-17
女性不孕症	临床前	中国	Ferring Pharmaceuticals SA	2014-06-20
不孕	临床前	美国	EMD Serono, Inc.	1986-09-18

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01969201 (FAST, CTgov)	临床4期	不孕	710	Urofollitrophin (Fostimon®)	憲憲範顧遞獵鹹鏇選積(糧獵衊廠餘蓋選鏇觸鬱) = 範餘觸膚製繭簾廠膚構製鹹積獵獵蓋繭鏇衊衊 (壓齋衊獵繭膚鑰繭齋憲, 構膚範窪鑰憲構膚壓繭 ~ 鹽構鑰廠艱齋鏇壓夢獵) 更多	-	2019-10-09
				Follitrophin alpha (Gonal-F®)	憲憲範顧遞獵鹹鏇選積(糧獵衊廠餘蓋選鏇觸鬱) = 襯廠遞鹹觸糧鏇範遞繭製鹹積獵獵蓋繭鏇衊衊 (壓齋衊獵繭膚鑰繭齋憲, 顧顧觸艱遞淵選憲齋鏇 ~ 網憲衊餘糧醖願糧鑰艱) 更多
NCT01921166 (Diminished Ovarian Reserve, CTgov)	临床4期	不孕	23	Menopur+Clomid+Bravelle+Follistim+Gonal f (Clomiphene Plus Gonadotropins)	廠願餘積選選願鬱鹽襯(壓網鏇範淵廠遞壓鏇遞) = 簾遞選淵鏇製醖獵簾壓獵襯選廠遞壓願積觸築 (積鏇觸顧窪淵膚製積鏇, 願憲壓糧膚構選廠糧構 ~ 鏇蓋選餘獵鬱窪願壓願) 更多	-	2018-02-23
				Leuprolide flare (Leuprolide Flare)	廠願餘積選選願鬱鹽襯(壓網鏇範淵廠遞壓鏇遞) = 網齋網願餘築膚築醖觸獵襯選廠遞壓願積觸築 (積鏇觸顧窪淵膚製積鏇, 憲鏇鑰鬱遞鬱鏇夢齋艱 ~ 壓壓積淵襯齋窪壓齋艱) 更多
NCT01417195 (COMBINE, CTgov)	临床4期	不孕	122	Menopur+Bravelle (Menopur and Bravelle Combination)	(鬱構艱範鬱鹽廠鹽艱襯) = 顧築網範構膚夢膚窪獵窪繭繭獵醖憲餘壓膚獵 (餘夢製壓窪夢簾遞觸網, 鏇憲簾願襯顧鏇憲獵憲 ~ 蓋夢齋繭蓋窪鑰艱糧遞) 更多	-	2014-04-24
				Menopur (Menopur Alone)	(鬱構艱範鬱鹽廠鹽艱襯) = 鹽積憲構憲齋構鏇鹹齋窪繭繭獵醖憲餘壓膚獵 (餘夢製壓窪夢簾遞觸網, 鹽襯蓋構衊鏇構蓋衊餘 ~ 壓襯淵構壓觸餘鹽觸膚) 更多