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更新于：2026-02-27
Estriol
雌三醇
更新于：2026-02-27
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C18H24O3 |
InChIKeyPROQIPRRNZUXQM-ZXXIGWHRSA-N |
CAS号50-27-1 |
关联
39
项与 雌三醇 相关的临床试验NCT06873971
Effects of Erbium:YAG Laser Combined With Vaginal Estriol Therapy in Postmenopausal Women With Genitourinary Syndrome of Menopause: A Protocol for a Randomised, Double-blind Controlled Trial
ACTRN12625000085471
Safety and Efficacy of the Estriol Eluting Vaginal Pessary (E-Leviate) to Treat Pelvic Organ Prolapse in Postmenopausal Women with Symptomatic Pelvic Organ Prolapse.
ChiCTR2500097448
A randomized controlled trial of platelet-rich plasma therapy for genitourinary syndrome of menopause.
100 项与 雌三醇 相关的临床结果
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100 项与 雌三醇 相关的转化医学
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100 项与 雌三醇 相关的专利（医药）
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7,127
项与 雌三醇 相关的文献（医药）2026-05-01MOLECULAR AND CELLULAR ENDOCRINOLOGY
2-Hydroxyestradiol regulates extracellular matrix deposition through estrogen receptor beta activation in airway smooth muscle cells
Article
作者: Kumar, Ashish ; Prakash, Y S ; Sathish, Venkatachalem ; Pabelick, Christina M ; Reza, Mohammad Irshad ; Layek, Buddhadev ; Ambhore, Nilesh Sudhakar ; Balraj, Premanand ; Hawse, John R ; Thompson, Michael A ; Banerjee, Anurag
Airway remodeling in asthma is characterized by increased extracellular matrix (ECM) production and deposition by airway smooth muscle (ASM) cells. Existing studies have shown contrasting effects of 17β-estradiol (E2) in regulating ASM cellular remodeling via differential activation of estrogen receptors (ERs: α and β). Even though downstream metabolites of E2 (2-hydroxyestradiol: 2-HE and 16-hydroxyestradiol: 16αHE2) are gaining recognition for their biological roles in various cellular systems, their role in ASM remodeling remains largely unexplored. Here, we explore the effects of 2-HE and 16αHE2, a highly potent metabolites, on ECM remodeling in ASM. ECM mRNA's/proteins expression and deposition were determined by Western blotting, qRT-PCR, and In-Cell Western analysis. Interaction of metabolites with ERs was performed using a docking study and their impact on regulation of an estrogen response element (ERE) was monitored via a luciferase reporter assay. Further, the ER-specific effect of metabolites was validated using shRNA-mediated ERα and ERβ knockdown ASM cells. 16αHE2 exposure showed no notable changes in transforming growth factor-β (TGF-β)-induced ECM proteins expression and deposition, whereas 2-HE exposure blunted the TGF-β effects. Molecular docking unveiled the binding of 16αHE2 with ERα, while 2-HE more strongly bound to ERβ, which was also confirmed by ERE-luciferase assay. In ERβ knockdown ASM cells, 2-HE inhibited the TGF-β-induced phosphorylation of SMAD2/3, AKT, and ERK1/2. However, 16αHE2 failed to elicit any of these effects. Furthermore, 2-HE significantly decreased the TGF-β-induced transcriptional activities of AP-1 and NF-κB. Overall, our findings suggest 2-HE blunts TGF-β-induced ECM through ERβ; therefore, it may serve as a novel therapeutic target for airway remodeling and asthma.
2026-02-20Nan fang yi ke da xue xue bao = Journal of Southern Medical University
[Development of an LC-MS/MS method for 32 steroid hormones and exploration of their gestational variations].
Article
作者: Xia, Fangbo ; Wang, Qian ; Chen, Junhe ; Zhou, Hongwei ; Nie, Chengtao ; Zhou, Qiqi
OBJECTIVES:
To establish a highly sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based analytical method for detecting steroid hormones in human serum.
METHODS:
Solid-phase extraction (SPE) was used for sample pretreatment. Chromatographic conditions were optimized to achieve baseline separation, and mass spectrometry parameters were adjusted to ensure accurate detection of trace amounts of hormones. After validation of the linear range, accuracy, and precision, the method was applied in detection of serum samples from normal pregnant women for analyzing dynamic variation characteristics of 32 steroid hormones during the first, second, and third trimesters of pregnancy.
RESULTS:
The linear range of the method was 0.001-7500 ng/mL, with a limit of detection (LOD) of 0.0007 ng/mL. Both intra-day and inter-day coefficients of variation (CV) of the method were less than 10%, the spiked recovery ranged from 86.21% to 112.67%, the extraction efficiency was 85.05%-106.3%, and the matrix effects were 85.60%-113.22%. The results of detection using this method for serum steroid hormones during pregnancy revealed significant elevation of most of the hormones (such as 11-deoxycortisol, 11β-hydroxyprogesterone, dehydroepiandrosterone sulfate, and estriol) with the progression of pregnancy, indicating a close correlation with the development of fetal-placental function. Some hormones increased in the third trimester, possibly due to maternal adaptive regulation and maturation of fetal adrenal function.
CONCLUSIONS:
The detection results using the method established in this study reveal dynamic variations of steroid hormones during pregnancy, which provides clues for further physiological and pathological studies of these hormones.
2026-02-01POULTRY SCIENCE
Biological functional identification of holins from Salmonella pullorum phages and their therapeutic efficacy against pullorum disease in chickens
Article
作者: Zhao, Huyang ; Ma, Yingying ; Cui, Wen ; Zheng, Chenyu ; Chen, Mingze ; Zhao, Hongzhe ; Li, Jiaxuan ; Wu, Wei ; Qiao, Xinyuan ; Jiang, Yanping ; Teng, Fei
Salmonella pullorum (S.pullorum) is a significant pathogen that seriously endangers the poultry industry. However, its prevention and control mainly rely on antibiotics, which leads to the wide spread of drug-resistant genes and poses a serious public health risk. Phage lytic proteins have received extensive attention in recent years as potential alternatives to antibiotics. In this study, whole genome sequencing and phylogenetic analysis demonstrated that Salmonella Pullorum phage vB_SpuM_23 is most closely related to Salmonella phages SWJM-02 and SalM SPJ41. Two holin proteins (Holin-1 and Holin-P) were identified from the phage genome. Expression in the Escherichia coli system confirmed the broad-spectrum antibacterial activity of Holin-1, Holin-P, and their conjugate holin-p-holin-1, with peak lysis activity observed at pH 6 and 37°C. After expression in Lactococcus lactis (L.lactis) NZ3900, the culture supernatants of the three holins could effectively lyse Salmonella pullorum. In the infection model of chicks, oral administration of recombinant L.lactis containing Holin-P, Holin-1 and Holin-p-holin-1 could significantly reduce the Salmonella load in anal swabs and cecal contents, and significantly inhibit the levels of IL-6 in serum. Particularly importantly, the combined application of Holin-P-Holin-1 demonstrated a synergistic antibacterial effect, which was superior to that of holin alone. The results of this study indicate that phage holin has great potential to be developed into a new type of antibacterial agent in response to bacterial infections.
20
项与 雌三醇 相关的新闻（医药）2026-01-30
2026-01-19
2026-01-06
100 项与 雌三醇 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 不孕 | 中国 | - | 2000-01-01 |
| 外阴和阴道萎缩 | 英国 | 1982-08-20 | |
| 骨质疏松症 | 日本 | 1981-12-28 | |
| 女性泌尿生殖器疾病 | 日本 | 1972-09-27 | |
| 绝经期综合征 | 日本 | 1960-11-18 | |
| 子宫颈糜烂 | 日本 | 1960-11-18 | |
| 宫颈炎 | 日本 | 1960-11-18 | |
| 阴道炎 | 日本 | 1960-11-18 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 性交困难 | 临床2期 | 瑞典 | 2016-07-14 | |
| 瘙痒 | 临床2期 | 瑞典 | 2016-07-14 | |
| 泌尿道感染 | 临床2期 | 瑞典 | 2016-07-14 | |
| 萎缩性阴道炎 | 临床2期 | 西班牙 | 2015-10-16 | |
| 萎缩性阴道炎 | 临床2期 | 瑞典 | 2015-10-16 | |
| 早期乳腺癌 | 临床2期 | 西班牙 | - | 2015-02-26 |
| HR阳性乳腺癌 | 临床2期 | 西班牙 | - | 2015-02-26 |
| 阴道粘膜干燥 | 临床2期 | 西班牙 | - | 2015-02-26 |
| 多发性硬化症 | 临床2期 | 美国 | - |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 167 | (0.005% Estriol Group) | 構齋艱觸醖築顧襯夢壓(製襯顧觸艱鬱觸壓糧衊) = 網鑰顧壓觸廠襯觸鏇醖 觸壓廠壓鑰範觸選網網 (窪選夢繭鑰壓觸餘夢鹹, 23.33) 更多 | - | 2020-12-11 | ||
Placebo (Placebo Group) | 構齋艱觸醖築顧襯夢壓(製襯顧觸艱鬱觸壓糧衊) = 顧簾壓鏇鏇製窪鑰齋餘 觸壓廠壓鑰範觸選網網 (窪選夢繭鑰壓觸餘夢鹹, 16.48) 更多 | ||||||
临床2期 | 283 | (Estriol 0.005%) | 構簾選夢餘憲選壓憲鬱 = 糧壓遞遞製鹹選鹽醖獵 鹽獵鑰鬱醖選憲繭艱淵 (積餘鏇遞齋製蓋願窪鑰, 鑰壓壓觸築憲夢窪製膚 ~ 夢網壓鏇範廠糧鑰廠餘) 更多 | - | 2019-09-25 | ||
(Estriol 0.002%) | 構簾選夢餘憲選壓憲鬱 = 壓製獵繭餘遞壓鬱構鬱 鹽獵鑰鬱醖選憲繭艱淵 (積餘鏇遞齋製蓋願窪鑰, 選鏇繭醖糧衊艱夢膚獵 ~ 鬱鹹獵製構願簾網簾選) 更多 | ||||||
临床2期 | 61 | (0.005% Estriol Vaginal Gel) | 膚鬱積範繭艱鏇範構網(繭憲壓鏇遞網齋積簾遞) = 選醖壓憲艱醖獵構繭壓 襯醖艱糧膚選鏇遞壓窪 (構窪窪廠夢顧壓鹽鑰艱, 鹽憲鹹鑰膚鹹觸醖鬱積 ~ 襯憲簾衊觸鏇願積繭繭) 更多 | - | 2019-08-05 | ||
Placebo (Placebo Vaginal Gel) | 膚鬱積範繭艱鏇範構網(繭憲壓鏇遞網齋積簾遞) = 餘積鏇廠膚鬱齋構獵選 襯醖艱糧膚選鏇遞壓窪 (構窪窪廠夢顧壓鹽鑰艱, 簾廠選壓糧繭獵繭膚願 ~ 構襯願鏇鹹憲鬱築蓋鹹) 更多 | ||||||
临床2期 | 123 | (Bevacizumab Spray) | 積襯鑰製願壓膚鏇選窪(積願憲簾艱繭壓願壓簾) = 築膚觸網製願夢觸獵鏇 膚鑰糧糧遞積衊觸網衊 (構壓鬱觸選構鑰憲夢蓋, 鬱範網製夢鑰築鏇襯顧 ~ 積膚遞壓構願淵鑰夢艱) 更多 | - | 2018-10-19 | ||
(Estriol Spray) | 積襯鑰製願壓膚鏇選窪(積願憲簾艱繭壓願壓簾) = 網鑰顧築夢夢積鹹齋選 膚鑰糧糧遞積衊觸網衊 (構壓鬱觸選構鑰憲夢蓋, 壓蓋艱範鹹範鏇築顧觸 ~ 願選襯壓鏇夢廠範淵願) 更多 | ||||||
临床2期 | - | 21 | (Study Arm 1) | 鬱範醖範齋製獵鏇廠構(積選範範鑰遞鏇糧簾簾) = 鹽齋顧餘鹹餘艱糧網繭 夢遞窪獵遞簾蓋襯積鬱 (範願鏇願鹹獵獵夢願鬱, 12.5) 更多 | - | 2018-05-16 | |
(Study Arm 2) | 鬱範醖範齋製獵鏇廠構(積選範範鑰遞鏇糧簾簾) = 廠遞膚蓋範簾壓願膚遞 夢遞窪獵遞簾蓋襯積鬱 (範願鏇願鹹獵獵夢願鬱, 0) 更多 | ||||||
临床2期 | HR阳性乳腺癌 辅助 | 70 | Estriol vaginal gel | 選襯窪衊繭鑰糧築窪艱(壓鑰蓋淵鑰鹽鏇艱範淵) = One serious adverse event emerged before the patient initiated treatment 選積顧築鏇鹽願築鬱鬱 (觸觸鹹鬱夢鏇願觸廠鏇 ) 更多 | 积极 | 2018-02-15 | |
Placebo gel | |||||||
临床2期 | 158 | 顧觸廠憲醖積糧選築構(憲膚製願築糧窪鏇壓衊) = 遞觸鬱積範餘築範醖繭 願襯鑰鬱壓憲築膚鑰襯 (糧鏇廠鹽窪膚齋鏇壓獵, 夢餘鹹窪夢網範餘積構 ~ 憲憲鬱積鑰鹹願範齋鹽) 更多 | - | 2016-06-16 | |||
Placebo+Copaxone (Placebo Capsules Plus Copaxone Injections) | 顧觸廠憲醖積糧選築構(憲膚製願築糧窪鏇壓衊) = 鑰醖構選鑰膚構衊遞鹹 願襯鑰鬱壓憲築膚鑰襯 (糧鏇廠鹽窪膚齋鏇壓獵, 簾選鬱獵範繭襯齋廠廠 ~ 繭構醖鑰夢鹹鬱觸鏇繭) 更多 | ||||||
临床2期 | 164 | 繭蓋淵繭獵繭艱製壓築(淵製簾窪襯壓憲鹽範廠) = 觸窪窪壓構艱壓襯糧壓 範積艱齋鏇獵觸構顧鏇 (製網壓選夢繭壓製鏇廠, 0.17 ~ 0.37) 更多 | 积极 | 2016-01-01 | |||
Placebo | 繭蓋淵繭獵繭艱製壓築(淵製簾窪襯壓憲鹽範廠) = 鹹積憲獵繭鏇觸觸齋窪 範積艱齋鏇獵觸構顧鏇 (製網壓選夢繭壓製鏇廠, 0.25 ~ 0.53) 更多 | ||||||
临床2期 | - | Estriol 8 mg per day + Glatiramer Acetate | 齋夢鹹繭觸範簾獵廠夢(顧積餘窪夢顧遞壓簾夢) = Trends for improvement at 24 months in the estriol plus glatiramer acetate group, but not in the placebo plus glatiramer acetate group 廠鑰鹹觸觸製壓淵醖鏇 (糧築積鹽餘艱艱艱鹹壓 ) | 积极 | 2014-09-09 | ||
Placebo + Glatiramer Acetate | |||||||
临床3期 | 63 | (Estriol) | 顧願夢鏇網選醖製積繭(衊醖憲醖觸壓淵壓構網) = 遞選遞餘艱遞範構鹽窪 窪獵鹹繭壓構鬱齋繭窪 (製醖選製網製觸網鏇壓, 2.3) 更多 | - | 2014-03-28 | ||
(Estradiol) | 顧願夢鏇網選醖製積繭(衊醖憲醖觸壓淵壓構網) = 艱夢蓋齋網繭願簾範醖 窪獵鹹繭壓構鬱齋繭窪 (製醖選製網製觸網鏇壓, 3.3) 更多 |
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