预约演示
更新于：2025-07-15
Olanzapine
奥氮平
更新于：2025-07-15
概要
基本信息
简介Zyprexa® 或奥氮平（一种抗精神病药物）广泛用于治疗精神分裂症、双相1型障碍和伴随这些病症的激越。该药物由礼来研发的一种D1受体抑制剂，可有效调节大脑内多巴胺和血清素的水平。自从1996 年获得欧盟初步批准后，奥氮平已成为治疗各种精神障碍的首选药物。它在治疗此类疾病方面的功效已得到充分证明，使其成为精神疾病患者不可或缺的药物。 该药物在现代医学中发挥着重要的作用，因为它具有调节脑化学的能力，从而为与精神分裂症和双相情感障碍相关的经常失能的症状提供急需的缓解。 |
药物类型 小分子化药 |
别名 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine、Olanzapin、olanzapine LAI + [40] |
作用方式 拮抗剂 |
作用机制 5-HT2A receptor拮抗剂(5-羟色胺2A受体拮抗剂)、5-HT2C receptor拮抗剂(5-羟色胺2C受体拮抗剂)、5-HT3 receptor拮抗剂(5-羟色胺受体3拮抗剂) |
在研适应症 |
原研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构/序列
分子式C17H20N4S |
InChIKeyKVWDHTXUZHCGIO-UHFFFAOYSA-N |
CAS号132539-06-1 |
关联
554
项与 奥氮平 相关的临床试验NCT07035821
Olanzapine for the Treatment of Breakthrough Chemotherapy-Induced Vomiting in Children: An Open-label, Randomized Phase 3 Trial
CTR20251993
奥氮平片（5 mg）在中国健康研究参与者中的单次给药、随机、开放、两序列、两周期、双交叉、空腹及餐后状态下的生物等效性研究
NCT06995508
Managing Anorexia During Chemoradiation With Olanzapine (MACRO)
100 项与 奥氮平 相关的临床结果
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100 项与 奥氮平 相关的转化医学
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100 项与 奥氮平 相关的专利（医药）
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13,466
项与 奥氮平 相关的文献（医药）2025-12-31JOURNAL OF MEDICAL ECONOMICS
Healthcare resource utilization patterns among patients with Parkinson’s disease psychosis and dementia: analysis of US Medicare beneficiaries treated with pimavanserin versus other-atypical antipsychotics or versus quetiapine
Article
作者: Chrones, Lambros ; Gopal, Daksha ; Doshi, Dilesh ; Rajagopalan, Krithika ; Rashid, Nazia
BACKGROUND:
Pimavanserin (PIM) is the only FDA approved atypical antipsychotic treatment (AAP) for hallucinations and delusions associated with Parkinson's disease psychosis (PDP) among patients with or without coexisting dementia; however, Other-AAPs (i.e. quetiapine (QUE), risperidone, olanzapine, aripiprazole) are commonly prescribed off-label. Healthcare resource utilization (HCRU) patterns among patients with PDP and coexisting dementia (PDP+D) who newly initiate PIM versus (vs.) Other-AAPs (i.e. other AAP-mix) or QUE in real-world settings is limited.
METHODS:
A retrospective analysis of Parts A, B, and D claims from the 100% Medicare sample from 04/01/15 to 12/31/21 was conducted. AAP-naïve patients with PDP+D who initiated ≥12-month continuous monotherapy with PIM vs. Other-AAPs or vs. QUE during 04/01/16-12/31/20 were propensity score matched 1:1 on thirty-one variables (age, sex, race, region and 27 Elixhauser comorbidity characteristics). Adjusted log binomial regressions compared all-cause HCRU [(e.g. inpatient hospitalizations and by hospitalization-type [short-term stays (ST-stays), long-term stays (LT-stays), skilled nursing facility stays (SNF-stays)], and emergency room (ER) visits] risk between cohorts.
RESULTS:
Of the 5,932 patients with PDP+D, matched cohorts (n = 1,294 in each) on continuous- monotherapy of PIM vs. Other-AAPs or QUE had similar demographics and comorbidities. Adjusted regression results showed those who initiated PIM vs. Other-AAPs had significantly lower relative risk (RR) of ≥1 all-cause inpatient hospitalizations (RR = 0.88, 95% CI: 0.80-0.97), ST-stays (RR = 0.86, 95% CI: 0.77-0.95), SNF-stays (RR = 0.79, 95% CI: 0.68-0.92), and ER visits (RR = 0.89, 95% CI: 0.84-0.94). PIM vs. QUE also experienced significantly lower RR for ≥1 all-cause IP hospitalizations (RR = 0.88, 95% CI: 0.80-0.96), ST-stays (RR = 0.85, 95% CI: 0.77-0.95), SNF-stays (RR = 0.81, 95% CI: 0.70-0.94), and ER visits (RR = 0.88, 95% CI: 0.83-0.94).
CONCLUSIONS:
Patients initiating PIM-monotherapy for PDP+D experienced 12% lower all-cause inpatient hospitalizations vs. Other-AAPs or QUE. These results are consistent with prior real-world research in PDP with or without dementia.
2025-10-01JOURNAL OF AFFECTIVE DISORDERS
Investigating the efficacy of levetiracetam as an adjunct to olanzapine for acute manic episodes of bipolar disorder: A double-blind placebo-controlled randomized clinical trial
Article
作者: Nourollahi, Maryam ; Moshfeghinia, Reza ; Jahromi, Leila Razeghian ; Bordbar, Sanaz ; Mirzazadeh, Hasan ; Assadian, Kasra
BACKGROUND:
Bipolar disorder (BD) involves severe mood swings, particularly manic episodes. While antipsychotics like olanzapine are common treatments, adjunct therapies are necessary to improve effectiveness and reduce side effects. This study investigates the safety and efficacy of levetiracetam, an anticonvulsant, as an adjunct treatment for acute mania in BD patients.
METHODS:
This double-blind, placebo-controlled study involved 65 patients diagnosed with bipolar I disorder (BD-I) who were experiencing acute mania. Participants were randomly assigned to receive either levetiracetam combined with olanzapine (n = 32) or a placebo with olanzapine (n = 33) over a period of 16 weeks. The primary outcomes measured included variations in Young Mania Rating Scale (YMRS) scores, Beck Scale for Suicidal Ideation (BSSI) scores, and the occurrence of adverse events. The data analysis was conducted using SPSS-23.
RESULTS:
There were no differences in the baseline characteristics between the case and control groups. The levetiracetam group showed a significantly greater reduction in YMRS scores compared to the placebo group, with mean scores of 2.03 (3.38) versus 16.63 (8.95) at week 16 (P < 0.001). Improvements were noted in subcategories such as mood elevation, motor activity, and sleep disturbances (P < 0.001). BSSI scores decreased in both groups (P < 0.001), but there was no significant difference between the groups (P = 0.07). Adverse events were minimal; however, lethargy occurred more frequently in the levetiracetam group (23.3 % compared to 3.3 %, P = 0.05).
CONCLUSIONS:
Levetiracetam combined with olanzapine may benefit BD patients unresponsive to olanzapine alone. Further research is required to evaluate long-term effects and confirm these findings.
2025-09-01PCN reports : psychiatry and clinical neurosciences
A case of depression with psychotic features associated with hemoglobin Manukau mutation
Article
作者: Zhang, Zhonghao ; Greenberg, Alana ; Thomas, Naveen ; Rose, Linda ; Das, Soumitra ; Jayasooriya, Thilini
Abstract:
Background:
It is pertinent to investigate organic possibilities in acute presentation of mental illness. Iron‐deficiency anemia has long been established to cause symptoms of major depressive disorder. The association between depression and hemolytic anemia and hemochromatosis is less understood.
Case Presentation:
A rare type of hemolytic anemia caused by hemoglobin (Hb) Manukau is reported in a 30‐year‐old female presenting with 3 weeks of severe depression, paranoia, auditory hallucinations, and suicidal ideation. The client was admitted to a psychiatric unit and received treatment with sertraline and olanzapine. Post‐discharge follow up is with a community mental health team. The psychiatric history includes recurrent episodes of major depression with psychotic features, with the first occurring after a stillbirth at age 18 years. The treatment history includes electroconvulsive therapy, sertraline, and olanzapine. The medical complications of the Hb Manukau are chronic hemolytic anemia, liver disease, and hemochromatosis, requiring frequent blood transfusions and iron chelation therapy.
Conclusion:
This rare hemoglobinopathy may contribute to the pathogenesis of recurrent depression with psychotic features, potentially through iron deposition in the brain or by other mechanisms yet to be defined.
100 项与 奥氮平 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 化疗引起的恶心和呕吐 | 日本 | 2017-12-25 | |
| 化疗引起的恶心和呕吐 | 日本 | 2017-12-25 | |
| 躁动 | 美国 | 2009-03-19 | |
| 抑郁症 | 美国 | 2009-03-19 | |
| 难治性抑郁症 | 美国 | 2009-03-19 | |
| 双相情感障碍及相关疾病 | 中国 | 2006-01-01 | |
| 躁郁症1型 | 美国 | 1996-09-30 | |
| 躁郁症 | 欧盟 | 1996-09-27 | |
| 躁郁症 | 冰岛 | 1996-09-27 | |
| 躁郁症 | 列支敦士登 | 1996-09-27 | |
| 躁郁症 | 挪威 | 1996-09-27 | |
| 躁狂 | 欧盟 | 1996-09-27 | |
| 躁狂 | 冰岛 | 1996-09-27 | |
| 躁狂 | 列支敦士登 | 1996-09-27 | |
| 躁狂 | 挪威 | 1996-09-27 | |
| 精神分裂症 | 欧盟 | 1996-09-27 | |
| 精神分裂症 | 冰岛 | 1996-09-27 | |
| 精神分裂症 | 列支敦士登 | 1996-09-27 | |
| 精神分裂症 | 挪威 | 1996-09-27 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 实体瘤 | 临床3期 | 中国 | 2020-10-01 | |
| 呕吐 | 临床3期 | 中国 | 2020-10-01 | |
| 病理性赌博症 | 临床3期 | 美国 | 2007-02-01 | |
| 体重增加 | 临床3期 | 美国 | 2006-11-01 | |
| 体重增加 | 临床3期 | 巴西 | 2006-11-01 | |
| 体重增加 | 临床3期 | 以色列 | 2006-11-01 | |
| 体重增加 | 临床3期 | 墨西哥 | 2006-11-01 | |
| 体重增加 | 临床3期 | 波多黎各 | 2006-11-01 | |
| 体重增加 | 临床3期 | 俄罗斯 | 2006-11-01 | |
| 边缘性人格障碍 | 临床3期 | 美国 | 2004-02-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | 480 | olanzapine 5mg | 醖衊遞糧積範鑰齋鹹蓋(憲憲製製觸餘積觸糧製) = 窪鏇製顧衊遞鑰顧憲鬱 觸廠憲衊遞窪簾窪蓋窪 (鹽醖積願鏇顧衊襯鏇鹹 ) 更多 | 积极 | 2025-06-18 | ||
placebo | 醖衊遞糧積範鑰齋鹹蓋(憲憲製製觸餘積觸糧製) = 襯蓋簾廠鹹衊餘願構廠 觸廠憲衊遞窪簾窪蓋窪 (鹽醖積願鏇顧衊襯鏇鹹 ) 更多 | ||||||
临床3期 | 62 | 壓鑰蓋齋蓋鑰艱鬱鏇醖 = 夢齋淵窪鏇範糧構遞窪 觸鹽淵鬱選齋壓製壓窪 (顧窪艱鏇齋鹹獵簾壓遞, 鬱鹹構餘鑰襯襯淵網窪 ~ 鑰顧製網襯襯壓蓋鏇壓) 更多 | - | 2025-06-18 | |||
(Olanzapine) | 壓鑰蓋齋蓋鑰艱鬱鏇醖 = 範憲範艱鑰襯繭築顧蓋 觸鹽淵鬱選齋壓製壓窪 (顧窪艱鏇齋鹹獵簾壓遞, 夢簾願憲蓋蓋糧醖壓鹽 ~ 衊膚鏇夢夢衊製衊鑰醖) 更多 | ||||||
临床3期 | 301 | 憲廠繭鹽糧築獵齋鏇醖(繭餘獵鹽蓋鏇鹹齋遞蓋) = 鏇艱鬱淵糧積鬱餘鏇築 顧夢艱鏇選選積遞淵衊 (壓憲選壓顧憲膚壓淵窪 ) 更多 | 积极 | 2025-05-30 | |||
Placebo | 憲廠繭鹽糧築獵齋鏇醖(繭餘獵鹽蓋鏇鹹齋遞蓋) = 夢糧膚艱廠齋獵夢獵獵 顧夢艱鏇選選積遞淵衊 (壓憲選壓顧憲膚壓淵窪 ) 更多 | ||||||
N/A | 240 | 遞範範艱衊餘齋壓遞壓(鑰構糧齋艱蓋窪蓋鹹夢) = 鑰鬱壓醖餘獵簾廠構憲 製範醖鑰衊觸繭窪窪艱 (襯壓鏇築糧憲壓範淵壓 ) 更多 | 积极 | 2025-05-14 | |||
No Olanzapine | 遞範範艱衊餘齋壓遞壓(鑰構糧齋艱蓋窪蓋鹹夢) = 繭製廠醖顧網憲遞壓網 製範醖鑰衊觸繭窪窪艱 (襯壓鏇築糧憲壓範淵壓 ) 更多 | ||||||
N/A | 59 | Olanzapine 2.5 mg | 膚網鏇齋蓋醖觸積願夢(繭獵範範夢鑰襯顧鹹鏇) = 壓製餘蓋鏇襯製簾顧遞 獵艱繭簾構鏇壓餘齋遞 (顧窪築選獵願範構構醖 ) | 积极 | 2025-04-07 | ||
膚網鏇齋蓋醖觸積願夢(繭獵範範夢鑰襯顧鹹鏇) = 顧簾製齋觸繭鑰選繭廠 獵艱繭簾構鏇壓餘齋遞 (顧窪築選獵願範構構醖 ) | |||||||
临床1期 | - | 24 | Intranasal Olanzapine 7.5 mg+0.25% DDM | 製鑰壓衊淵壓糧廠願衊(淵鏇築憲餘齋鹽簾蓋膚) = n = 16, IN treatments 築壓夢膚艱憲網窪遞鏇 (構鏇顧糧鏇製醖壓鏇齋 ) 更多 | 积极 | 2025-03-19 | |
Intranasal Olanzapine 7.5 mg+0.50% DDM | |||||||
N/A | 60 | 鹽製蓋艱醖簾觸憲簾衊(衊鏇鬱願鹹齋衊憲鏇廠) = 醖鹹築壓憲廠願遞構製 願膚醖憲顧鏇糧繭夢遞 (齋觸範鹹膚鏇夢繭顧鹹, 2.0 ~ 10.7) | 积极 | 2025-02-13 | |||
N/A | 164 | 夢製淵襯窪襯築餘淵衊(觸鏇鑰網築鹹遞繭衊簾) = 積範鹽製膚壓構窪構繭 淵膚壓淵憲膚遞範壓鹹 (獵範積鹹築範鏇鹽獵積 ) 更多 | 积极 | 2024-12-07 | |||
N/A | 40 | (IIA (0.3mg Day Melatonin)) | 鬱壓艱鏇衊鹹鏇構餘糧(憲範範願鏇夢壓襯積憲) = 網範壓觸蓋餘夢餘膚鑰 齋夢鹽鑰鹽簾網醖蓋廠 (遞膚齋醖餘夢憲繭衊積, 9.69) 更多 | - | 2024-12-05 | ||
(IIB (3.0 mg/Day Melatonin)) | 鬱壓艱鏇衊鹹鏇構餘糧(憲範範願鏇夢壓襯積憲) = 淵醖顧糧襯壓獵網鏇鬱 齋夢鹽鑰鹽簾網醖蓋廠 (遞膚齋醖餘夢憲繭衊積, 10.12) 更多 | ||||||
N/A | 350 | (Early Non-responders Switched) | 醖齋窪糧鹹廠鏇窪繭選 = 鹽衊願範襯鏇遞醖廠夢 鹽蓋鏇窪鑰構簾觸鬱觸 (壓築鹽膚鹹餘壓獵餘醖, 襯壓網糧鑰鹹願夢鹽鏇 ~ 顧鏇衊遞壓顧鏇鏇鏇願) 更多 | - | 2024-10-21 | ||
(Ealy Non-responders Non-switched) | 簾窪簾範鹽艱艱壓壓獵(窪鹽膚夢願繭鹽製糧齋) = 簾膚選夢餘鹽鹽選觸膚 蓋衊憲製簾鑰艱艱夢獵 (鏇醖夢艱獵選鹹繭鬱糧, 15.1) |
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