A Prospective, Single-center, Single-arm Clinical Study of Adebrelimab in Combination With Vunakizumab and Chemotherapy as First-line Treatment for Extensious-stage Small Cell Lung Cancer

This study is a prospective, single-center, single-arm clinical trial, with a planned enrollment of 28 cases.The first Adebrelimab +Vunakizumab +EC was administered within 72 hours after enrollment for 4 to 6 cycles.At the end of the combination phase, non-PD subjects entered the maintenance treatment period of Adebrelimab plus Vunakizumab.Treatment will continue until any of the following situations occur: disease progression in the subject, intolerable toxic and side effects, comorbidiments that affect further treatment, the investigator's decision to withdraw the subject from the study, or other reasons for non-compliance with the study treatment or the study procedures or protocols.

开始日期2025-09-01

申办/合作机构

福建省肿瘤医院（福建省肿瘤研究所、福建省癌症防治中心）

NCT07063407

/ Not yet recruiting临床1期

A Phase I Clinical Study Evaluating Safety, Tolerability, Pharmacokinetics and Efficacy of Intravenous HS-20093 Combinations in Patients With Extensive Stage Small Cell Lung Cancer

This is a Phase I clinical study of HS-20093. The purpose of this study is to evaluate the safety, tolerability, PK and efficacy of HS-20093 in combination with Adebrelimab in patients with Extensive Stage Small Cell Lung Cancer (ES-SCLC).

开始日期2025-07-31

申办/合作机构

上海翰森生物医药科技有限公司

NCT07059221

/ Recruiting临床1/2期

A Multicenter, Open-label Phase Ib/II Clinical Trial of SHR-A2102 Injection in Combination With Adebrelimab Injection, With or Without Other Anti-tumor Therapies, in Subjects With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

The study is being conducted to evaluate the safety, tolerability and efficacy of SHR-A2102 with Adebrelimab with or without other Antitumor Therapy in Subjects with Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma.
To explore the reasonable dosage of SHR-A2102 for n Subjects with Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

开始日期2025-07-11

申办/合作机构

苏州盛迪亚生物医药有限公司

100 项与阿得贝利单抗相关的临床结果

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100 项与阿得贝利单抗相关的转化医学

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100 项与阿得贝利单抗相关的专利（医药）

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项与阿得贝利单抗相关的文献（医药）

2025-06-01·BMJ Open

Clinical study of adebrelimab in combination with apatinib and irinotecan for PD-1 inhibitor-ineffective advanced-stage gastric cancer: study protocol for a single-arm, single-centre, exploratory trial

Article

作者: Xia, Xiang ; Guan, Yujing ; Bai, Long ; Aimaiti, Muerzhate ; Zhang, Hao-yu ; Wang, Shuchang ; Ni, Bo ; Yue, Ben ; Gu, Jiayi ; Liu, Tao ; Zhang, Zizhen ; Zhang, Yeqian

Introduction:

Immunotherapy has revolutionised cancer treatment. Immune checkpoint inhibitors have demonstrated significant efficacy across multiple tumour types, including gastric cancer, where several approved programmed cell death 1/programmed cell death-ligand 1 (PD-1/PD-L1) inhibitors show promising antitumour activity. While PD-L1 expression serves as a predictive biomarker for PD-1 inhibitor response, and PD-L1-positive patients generally show better outcomes, therapeutic resistance remains a challenge. Many initial responders eventually develop resistance, and surprisingly, some PD-L1-positive patients fail to achieve expected response rates, indicating emerging resistance mechanisms in potentially responsive populations. Adebrelimab, a PD-L1 inhibitor, demonstrates mechanistic advantages over PD-1 inhibitors, with clinical studies suggesting promising therapeutic potential. When combined with irinotecan, apatinib has shown efficacy in second-line gastric cancer treatment. This study aims to evaluate the efficacy and safety of combining adebrelimab with apatinib and irinotecan for advanced gastric cancer refractory to PD-1 inhibitors.

Method and analysis:

This single-arm, single-centre exploratory trial will be conducted at Renji Hospital, enrolling 32 patients aged 18–75 years. Eligible patients must have initially achieved partial response, complete response or stable disease with progression-free survival (PFS)≥3 months during prior immunotherapy but subsequently progressive disease on imaging. Treatment will continue until meeting discontinuation criteria. The primary endpoint is objective response rate with Clopper-Pearson 95% CI. Secondary endpoints include disease control rate (95% CI), PFS and overall survival (estimated by Kaplan-Meier method), along with safety assessments.

Ethics and dissemination:

All participants will provide informed consent. The protocol has been approved by the Shanghai Jiaotong University School of Medicine, Renji Hospital Ethics Committee (LY2023-201-C). The results will be disseminated through peer-reviewed manuscripts, reports and presentations.

Trial registration number:

ChiCTR2300077329.

2025-05-01·Clinical Lung Cancer

Phase I Clinical Trial of Autologous Hematopoietic Stem Cell Transplantation-Supported Dose-Intensified Chemotherapy With Adebrelimab as First-Line Treatment for Extensive-Stage Small Cell Lung Cancer

Article

作者: Zhang, Jiexia ; Zhou, Chengzhi ; Xie, Zhanhong ; Liu, Ming ; Lin, Xinqing ; Qin, Yinyin ; Guan, Wenhui ; Xu, Xin ; Li, Zekun ; Xie, Xiaohong ; Huang, Zhenqian ; Qiu, Guihuan

BACKGROUND:

Small cell lung cancer (SCLC) is initially highly sensitive to chemotherapy, which often leads to significant tumor reduction. However, the majority of patients eventually develop resistance, and the disease is further complicated by its "cold" tumor microenvironment, characterized by low tumor immunogenicity and limited CD8+ T cell infiltration. These factors contribute to the poor response to immunotherapy in many cases of extensive-stage SCLC (ES-SCLC). High-dose chemotherapy has shown potential in enhancing tumor cytoreduction, but its use is often limited by severe hematologic toxicity. Combining chemotherapy with immune checkpoint inhibitors (ICIs) can create a synergistic effect by promoting immunogenic cell death and enhancing immune activation. Autologous hematopoietic stem cell transplantation (auto-HSCT) provides a means to support hematopoietic recovery, mitigate chemotherapy-induced myelosuppression, and contribute to immune reconstitution. In this context, the integration of auto-HSCT with dose-intensified chemotherapy and ICIs aims to both protect the bone marrow and enhance antitumor immune responses, potentially overcoming resistance to immunotherapy in ES-SCLC.

METHODS:

A phase I, single-center, single-arm trial was designed to evaluate the safety and efficacy of auto-HSCT-supported dose-intensified chemotherapy combined with adebrelimab in treatment-naive ES-SCLC patients. Participants will receive induction chemotherapy followed by stem cell mobilization, apheresis, and cryopreservation. After successful mobilization, consolidation chemotherapy with stem cell reinfusion and granulocyte colony-stimulating factor (G-CSF) support will be performed. Maintenance therapy with adebrelimab continues until disease progression or unacceptable toxicity. Safety and efficacy data, including adverse events, objective response rate (ORR), progression-free survival (PFS), and overall survival (OS), will be analyzed.

RESULTS:

The study aims to enhance treatment outcomes by overcoming resistance to immuno-chemotherapy and promoting immune reconstitution. The trial is ongoing at the First Affiliated Hospital of Guangzhou Medical University.

TRIAL REGISTRATION:

ClinicalTrials.gov Identifier: NCT06597513.

2025-04-01·Cancer Communications

A prospective, phase II, neoadjuvant study based on chemotherapy sensitivity in HR+/HER2‐ breast cancer‐FINEST study

Article

作者: Liu, Guang‐Yu ; Li, Jun‐Jie ; Wu, Wen‐Ya ; Liang, Fei ; Wu, Jiong ; Yu, Ke‐Da ; Chen, Li ; Di, Gen‐Hong ; Wang, Zhong‐Hua ; Fan, Lei ; Shao, Zhi‐Ming

Abstract:

Background:

Hormone receptor‐positive (HR+)/humaal growth factor receptor 2‐negative (HER2‐) breast cancer, the most common breast cancer type, has variable prognosis and high recurrence risk. Neoadjuvant therapy is recommended for median‐high risk HR+/HER2‐ patients. This phase II, single‐arm, prospective study aimed to explore appropriate neoadjuvant treatment strategies for HR+/HER2‐ breast cancer patients.

Methods:

Eligible female patients with newly diagnosed, untreated HR+/HER2‐ breast cancer received 2 cycles of nab‐paclitaxel and carboplatin (nabPCb). Magnetic resonance imaging (MRI) was performed to assess tumor responses, and 40% regression of the maximal tumor diameter was deemed chemo‐sensitive. Chemo‐sensitive patients continued nabPCb for 4 more cycles (group A). Chemo‐insensitive patients were randomized to groups B, C, and D at a ratio of 1:3:1 to receive a new chemotherapy for 4 cycles or endocrine‐immune‐based therapy (dalpiciclib, letrozole and adebrelimab, with goserelin if patients were premenopausal) for 4 cycles or to undergo surgery. Peripheral blood and core‐needle biopsy (CNB) samples were collected before treatment, followed by a next‐generation sequencing (NGS) panel detection and similarity network fusion (SNF) typing through digital pathology data. The primary endpoint was the pathological complete response (pCR) rate, and the secondary endpoint was the clinical objective response rate (ORR).

Results:

A total of 121 patients were enrolled (67.8% with stage III disease), with 76, 9, 27, and 9 patients in groups A, B, C and D, respectively. The total pCR rate was 4.1%, and all patients who received pCR were in group A. Group C had a better ORR than Group B (81.5% vs. 66.7%). Exploratory analysis revealed that patients with the SNF4 subtype were the most sensitive to nabPCb (pCR rate of 21.1% vs. 1.8% in group A), whereas patients in group C with the SNF2 subtype were more sensitive to endocrine‐immune‐based therapy (Miller‐Payne grade 4‐5, 45.5% vs. 6.3%).

Conclusions:

Converting to endocrine‐immune‐based therapy improved the ORR, but not the pCR rate in chemo‐insensitive patients. Neoadjuvant chemotherapy and endocrine therapy are not mutually exclusive. The SNF4 subtype of HR+/HER2‐ breast cancer was more chemo‐sensitive, whereas the SNF2 subtype might be more sensitive to immunotherapy.

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项与阿得贝利单抗相关的新闻（医药）

2025-07-27

·ioncology

ESMO 2025丨59项中国泌尿肿瘤研究入选ESMO大会，一文畅览

点击蓝字，关注我们编者按：2025年欧洲肿瘤内科学会（ESMO）年会将于10月17日~21日在德国柏林召开。作为肿瘤学界的年度盛典，ESMO每年都会吸引上万名世界各地的肿瘤学大咖，为全球学者提供了良好的交流平台。目前公布的摘要标题中，入选的中国泌尿肿瘤研究数量再创新高，达到59篇，在此邀您共赏~口头报告摘要号：2592MO英文标题：Fruquintinib (FRUQ) plus sintilimab (SIN) versus axitinib (AXI) or everolimus (EVE) monotherapy as 2L treatment in pts with locally advanced or metastatic renal cell carcinoma (RCC)： results from phase 3 part of a randomized, open-label, active-controlled phase 2/3 study (FRUSICA-2)中文标题：呋喹替尼联合信迪利单抗对比阿昔替尼或依维莫司单药治疗局部晚期或转移性肾细胞癌患者的2L治疗：随机、开放标签、活性药物对照2/3期研究的3期部分结果（FRUSICA-2）讲者：叶定伟教授复旦大学附属肿瘤医院当地时间：Fri, 17.10.2025 16：00 - 17：30地点：Karlsruhe Auditorium - Hall 5.2摘要号：2598MO英文标题：The Intratumor Mycobiome Promotes Clear Cell Renal Cell Carcinoma Progression via Neutrophil-Mediated Immune Suppression中文标题：肿瘤内真菌群通过中性粒细胞介导的免疫抑制促进透明细胞肾细胞癌进展讲者：Kangli Ma 中国上海当地时间：Sun, 19.10.2025 08:30 - 10:00地点：Bonn Auditorium - Hall 7.1c摘要号：3071MO英文标题：Disitamab Vedotin plus Tislelizumab as Nephron-Sparing Therapy for High-Risk Upper Tract Urothelial Carcinoma： The Phase II DISTINCT-I Trial中文标题：维迪西妥单抗联合替雷利珠单抗作为高危上尿路尿路上皮癌的肾单位保留疗法：II 期 DISTINCT-I 临床试验讲者：黄吉炜教授上海交通大学医学院附属仁济医院当地时间：Sun, 19.10.2025 08:30 - 10:00地点：Bonn Auditorium - Hall 7.1c前列腺癌及阴茎癌壁报摘要号：1055P英文标题：Neoadjuvant and/or adjuvant immune checkpoint inhibitors combined with chemotherapy for locally advanced resectable penile squamous cell carcinoma中文标题：新辅助和/或辅助免疫检查点抑制剂联合化疗治疗局部晚期可切除阴茎鳞状细胞癌讲者：Zhao Zhigang 中国天津摘要号：2431P英文标题：The impact of lead-in androgen-deprivation therapy (ADT) on severe neutropenia (grade≥3) caused by docetaxel in patients with metastatic, hormone-sensitive prostate cancer(mHSPC)： A Post Hoc Analysis of ARASENS中文标题：转移性激素敏感前列腺癌（mHSPC）患者引入雄激素剥夺疗法（ADT）对多西他赛所致重度中性粒细胞减少症（≥3级）的影响：ARASENS的事后分析讲者：Yufan Y. Zhao 中国上海摘要号：2434P英文标题：The efficacy of rezvilutamide (Rez) plus androgen-deprivation therapy (ADT) in patients (pts) with high-volume, nonvisceral metastatic hormone-sensitive prostate cancer (HSPC)： a post hoc analysis of CHART study中文标题：瑞维鲁胺联合雄激素剥夺疗法（ADT）对高容量非内脏转移性激素敏感性前列腺癌（HSPC）患者的疗效：CHART研究的事后分析讲者：戴波教授复旦大学附属肿瘤医院摘要号：2435P英文标题：Predictive value of HSD3B1 germline single nucleotide polymorphism rs1047303 for hormone therapy outcomes in Chinese prostate cancer patients中文标题：HSD3B1种系单核苷酸多态性rs1047303对中国前列腺癌患者激素治疗结局的预测价值讲者：Ruofan Shi 中国上海摘要号：2436P英文标题：Efficacy and Safety of All-Site Radiation Therapy and Standard of Care Therapy with or without Docetaxel for Hormone-Sensitive High Gleason Score Prostate Cancer： 6-Year Results from a Long-Term Study中文标题：全部位放射治疗和标准治疗联合或不联合多西他赛治疗高格里森评分的激素敏感性前列腺癌的疗效和安全性：一项长期研究的6年结果讲者：Huizhu Chen 中国北京摘要号：2439P英文标题：Two-year Outcomes in Very High-Risk Localized Prostate Cancer Following Neoadjuvant Therapy with Poly(ADP-ribose) Polymerase Inhibitors and Abiraterone： A Pooled Post-Hoc Analysis of Two Prospective Trials中文标题：极高危局限性前列腺癌患者接受PARP抑制剂联合阿比特龙新辅助治疗后的两年疗效：两项前瞻性试验的汇总事后分析讲者：Tingwei Zhang 中国上海摘要号：2449P英文标题：CHAMPION study (NCT05717582) ： a prospective study of maximal-cytoreductive therapies for patients with de novo metastatic hormone-sensitive prostate cancer who achieve oligopersistent metastases during systemic treatment with apalutamide plus androgen deprivation therapy中文标题：CHAMPION研究：一项针对在接受阿帕他胺联合雄激素剥夺疗法全身治疗期间出现寡持续性转移的原发转移性激素敏感性前列腺癌患者的最大细胞减灭疗法的前瞻性研究讲者：Jian Pan 中国上海摘要号：2450P英文标题：Phase 1 study of QLH12016, an androgen receptor (AR) PROTAC degrader in heavily pretreated patients with metastatic castration-resistant prostate cancer (mCRPC)： safety, tolerability, and antitumor activity中文标题：雄激素受体（AR）PROTAC降解剂QLH12016在转移性去势抵抗性前列腺癌（mCRPC）患者中开展的I期临床试验：安全性、耐受性和抗肿瘤活性讲者：张顺教授南京鼓楼医院摘要号：2453P英文标题：Rezvilutamide (REZ) in combination with androgen-deprivation therapy (ADT) for prostate cancer patients with biochemical recurrence (BCR) post radical prostatectomy (RP)： preliminary results from a phase 2 trial中文标题：瑞维鲁胺联合雄激素剥夺疗法（ADT）治疗根治性前列腺切除术（RP）后生化复发（BCR）的前列腺癌患者：一项2期临床试验的初步结果讲者：邱雪峰教授南京鼓楼医院摘要号：2454P英文标题：RAPID trial (NCT06251492)： Radiation and Adebrelimab in Metastatic Castration Resistant Prostate Cancer with Imaging-Measurable Disease中文标题：RAPID试验：放疗和阿得贝利单抗治疗伴影像学可测量病变的转移性去势抵抗性前列腺癌讲者：Yu Wei 中国上海摘要号：2456P英文标题：Olaparib Plus Abiraterone in HRR-Mutated Metastatic Hormone-Sensitive Prostate Cancer中文标题：奥拉帕利联合阿比特龙治疗HRR突变转移性激素敏感性前列腺癌讲者：庄君龙教授南京鼓楼医院摘要号：2466P英文标题：Sodium-glucose cotransporter 2 inhibitors use in prostate cancer patients undergoing hormone therapy： a sequential target trial emulation study中文标题：钠-葡萄糖协同转运蛋白2抑制剂在接受激素治疗的前列腺癌患者中的应用：序贯靶向试验模拟研究讲者：Ruofan Shi 中国香港摘要号：2476P英文标题：Neoadjuvant darolutamide plus ADT for High/Very-high risk locally advanced PCa： a multi-center, open label, single arm, phase 2 trial中文标题：达罗他胺联合ADT新辅助治疗高危/极高危局部晚期前列腺癌：一项多中心、开放标签、单组、2期临床试验讲者：Kaiwei Yang 中国北京摘要号：2480P英文标题：A Randomized Controlled Clinical Trial on Autologous Vas Deferens Sling Suspension of the Vesicourethral Anastomosis to Improve Early Urinary Control After Retzius-sparing Robotic-assisted Radical Prostatectomy中文标题：自体输精管悬吊带悬吊膀胱尿道吻合口改善保留Retzius的机器人辅助根治性前列腺切除术后早期排尿控制的随机对照临床试验讲者：ZhiYuan Yang 中国南京摘要号：2481P英文标题：Pathological and Clinical Characteristics of Prostate Biopsy Cases with PSA Levels Below 4.0 ng/mL： A Multicenter Retrospective Real-World Study (YHCG-003 Study)中文标题：PSA水平低于4.0 ng/mL的前列腺穿刺活检病例的病理和临床特征：一项多中心回顾性真实世界研究（YHCG-003研究）讲者：苏瑞教授宁波大学附属第一医院摘要号：2482P英文标题：The Role of Sustained Serum Sodium Levels in Prognostication of Metastatic Prostate Cancer： Findings from Global Phase III Trials中文标题：血清钠水平持续在转移性前列腺癌预后中的作用：来自全球III期临床试验的结果讲者：倪旭栋教授复旦大学附属肿瘤医院摘要号：2486P英文标题：Quality of Life Analysis in Patients with High-Risk Localized Prostate Cancer Receiving Neoadjuvant Pamiparib plus Abiraterone and ADT： A Prospective Study中文标题：接受帕米帕利联合阿比特龙及ADT新辅助治疗的高危局限性前列腺癌患者生活质量分析：一项前瞻性研究讲者：Tangtao Gong 中国南京摘要号：2487P英文标题：Clinical Management Strategies and Long-Term Outcomes in Patients with Atypical Small Acinar Proliferation Diagnosed via Prostate Biopsy： A Collaborative Multicenter Real-World Study by Urologists and Pathologists (YHCG-002 Study)中文标题：前列腺穿刺活检确诊为非典型小腺泡增生患者的临床管理策略及长期疗效：一项泌尿科医生与病理科医生合作开展的多中心真实世界研究（YHCG-002研究）讲者：马琪教授宁波大学附属第一医院摘要号：2494P英文标题：Interim Analysis of a Prospective, Non-Randomized Controlled Study： Comparison of the Efficacy and Safety of ADT + Docetaxel vs. ADT + Novel Hormone Therapy in High Gleason Score Non-Metastatic Prostate Cancer Patients Receiving Radiotherapy中文标题：前瞻性、非随机对照研究的中期分析：ADT+多西他赛对比ADT+新型激素疗法在接受放射治疗的高Gleason评分非转移性前列腺癌患者中的疗效和安全性比较讲者：Mingwei Ma 中国北京摘要号：2523eP英文标题：Preclinical pharmacokinetic and pharmacodynamic study of GS24-B039, a 3-month long-acting abiraterone prodrug中文标题：疗效长达3个月的阿比特龙药物前体GS24-B039的临床前药代动力学和药效学研究讲者：Yujie Zhang 中国成都摘要号：2527eP英文标题：Baseline 68Ga-PSMA PET-CT for treatment monitoring of neoadjuvant prostate cancer： a diagnostic evaluation中文标题：用于前列腺癌新辅助治监测的68Ga-PSMA PET-CT基线：诊断评估讲者：Qing Zhang 中国南京摘要号：2530eP英文标题：HER2 Expression Dynamics and Prognostic Value in matched Hormone-Sensitive and Castration-Resistant Prostate Cancer Lesions中文标题：HER2在匹配的激素敏感性和去势抵抗性前列腺癌病变中的表达动态和预后价值讲者：Yelin Mulati 中国北京尿路上皮癌壁报摘要号：3075P英文标题： Circulating and Urine Tumor DNA Dynamics Predict Minimal Residual Disease and Guide Adjuvant Therapy in Locally Advanced Upper Tract Urothelial Carcinoma (CURATE-UTUC)： A Multicenter Prospective Longitudinal Cohort Study中文标题：循环和尿液肿瘤DNA动态预测局部晚期上尿路尿路上皮癌的微小残留病灶并指导辅助治疗（CURATE-UTUC）：一项多中心前瞻性纵向队列研究讲者：黄吉炜教授上海交通大学医学院附属仁济医院摘要号：3076P英文标题： Final results of a multi-center phase Ib/II study of RC48-ADC combined with tislelizumab as neoadjuvant treatment in patients with HER2 positive locally advanced muscle-invasive urothelial bladder cancer（Hope-03）中文标题：RC48-ADC联合替雷利珠单抗治疗HER2阳性局部晚期肌层浸润性膀胱癌患者的多中心Ib/II期临床研究最终结果（Hope-03）讲者：Feng Wen 中国成都摘要号：3079P英文标题： Efficacy and safety results from Formula-01： a phrase II study of Disitamab Vedotin plus BCG in HER2 high expression high-risk non-muscle invasive bladder cancer patients (HR-NMIBC)中文标题：Formula-01的疗效和安全性结果：维迪西妥单抗联合BCG治疗HER2高表达高危非肌层浸润性膀胱癌患者（HR-NMIBC）的II期临床讲者：Xingliang Tan 中国广州摘要号：3085P英文标题： PUNCH02： Interim results from a phase II study of tislelizumab combined with disitamab vedotin as a bladder preservation therapy for urine tumor DNA (utDNA)-defined clinical complete response (cCR) MIBC patients中文标题：PUNCH02：替雷利珠单抗联合维迪西妥单抗用于治疗尿液肿瘤DNA（utDNA）定义的临床完全缓解（cCR）MIBC患者的膀胱保留疗法的II期临床中期结果讲者：Bin Huang 中国成都摘要号：3086P英文标题： A Phase 2 Study of Organ-Preserving Therapy and Liquid Biopsy-Based Response Monitoring in Locally Advanced Muscle-Invasive Bladder Cancer中文标题：局部晚期肌层浸润性膀胱癌器官保留治疗及基于液体活检疗效监测的II期研究讲者：Jiani Deng 中国成都摘要号：3097P英文标题： Build an Artificial Intelligence Prediction Model Based on Deep Learning Technology to Predict the Muscular Invasion of Urothelial Carcinoma Preoperatively中文标题：基于深度学习技术构建人工智能预测模型，术前预测尿路上皮癌肌层浸润情况讲者：Sheng Xie 中国南充摘要号：3098P英文标题： Fibroblast Growth Factor Receptor 3 (FGFR3) - Driven Genomic Landscape and the Impact on Clinical Outcomes of Fexagratinib (Fexa) in Chinese metastatic or unresectable Urothelial Carcinoma (mUC)中文标题：成纤维细胞生长因子受体3（FGFR3）-驱动的基因组特征以及Fexagratinib对中国转移性或不可切除尿路上皮癌（mUC）临床结局的影响讲者：叶定伟教授复旦大学附属肿瘤医院摘要号：3099P英文标题： Proteogenomic characterization of the non-muscle-invasive bladder cancer response to BCG reveals potential therapeutic strategies中文标题：非肌层浸润性膀胱癌对BCG反应的蛋白质组学表征揭示了潜在的治疗策略讲者：Maoping Cai 中国上海摘要号：3103P英文标题： Chemotherapy plus Toripalimab as Neoadjuvant Therapy for Locally Advanced Upper Tract Urothelial Carcinoma： Mid-term Results from the Phase II, Multi-center Study (WUTSUP-01)中文标题：化疗联合特瑞普利单抗作为局部晚期上尿路尿路上皮癌的新辅助治疗：II期多中心临床研究（WUTSUP-01）的中期结果讲者：Kai Chen 中国成都摘要号：3110eP英文标题： Cost-Effectiveness of ctDNA-Guided Atezolizumab Adjuvant Therapy for High-Risk Muscle-Invasive Urothelial Carcinoma中文标题：ctDNA指导下的阿替利珠单抗辅助治疗高危肌层浸润性尿路上皮癌的成本效益讲者：Zihan Xue 中国天津摘要号：3114eP英文标题： Changes in Circulating Tumor Cells (CTCs) and HER-2 Expression as Indicators of Efficacy and Recurrence Prediction in Neoadjuvant Disitamab Vedotin (DV) Plus Toripalimab Treatment for Muscle-Invasive Bladder Cancer (MIBC)： Updated Data and Preliminary Outcomes for Recurrence中文标题：循环肿瘤细胞（CTC）及HER-2表达变化作为新辅助维迪西妥单抗联合特瑞普利单抗治疗肌层浸润性膀胱癌（MIBC）疗效及复发预测指标：最新数据及复发初步结果讲者：Yudong Cao 中国北京摘要号：3125eP英文标题： Kidney-Sparing Approach for Selected Localized High-Risk Upper Tract Urothelial Carcinoma： A Pilot Study Combining Endoscopic Thulium Laser Ablation with Perioperative Disitamab Vedotin and Immune Checkpoint Inhibitors中文标题：选择性局限性高危上尿路尿路上皮癌的肾脏保留疗法：内镜铥激光消融术联合围手术期维迪西妥单抗及免疫检查点抑制剂的初步研究讲者：Qihao Wang 中国成都摘要号：3127eP英文标题： Bulumtatug Fuvedotin (BFv 9MW2821), a novel Nectin-4 antibody-drug conjugate(ADC), combined with Toripalimab in patients with locally advanced or metastatic urothelial carcinoma(la/mUC)： Follow-up results from a phase 1b/2 study.中文标题：Bulumtatug Fuvedotin（BFv 9MW2821），一种新型Nectin-4抗体偶联药物（ADC），与特瑞普利单抗联合治疗局部晚期或转移性尿路上皮癌（la/mUC）患者：1b/2期研究的后续结果讲者：Shusuan Jiang 中国长沙肾癌壁报摘要号：2602P英文标题：Safety and efficacy of iparomlimab and tuvonralimab (QL1706) plus lenvatinib in previously untreated patients with clear cell renal cell carcinoma： results from a phase 1b study中文标题：艾帕洛利托沃瑞利单抗（QL1706）联合仑伐替尼治疗未经治疗的透明细胞肾细胞癌患者的安全性和有效性：一项1b期研究的结果讲者：董培中山大学肿瘤防治中心摘要号：2608P英文标题：Early detection of renal cell carcinoma： A novel cfDNA fragmentomics-based liquid biopsy assay.中文标题：肾细胞癌的早期检测：一种基于cfDNA片段组学的新型液体活检检测方法讲者：彭毓璐教授中山大学肿瘤防治中心摘要号：2615P英文标题：Belzutifan Plus Lenvatinib For Chinese Participants (pts) With Previously Treated Advanced Clear Cell Renal Cell Carcinoma (ccRCC)： Updated Results of Cohort 1 of the LITESPARK-010 Study中文标题：贝组替凡联合仑伐替尼治疗既往接受过治疗的晚期透明细胞肾细胞癌（ccRCC）中国患者：LITESPARK-010研究队列1更新结果讲者：盛锡楠教授北京大学肿瘤医院摘要号：2621P英文标题：Efficacy and safety of adjuvant penpulimab in very high-risk clear cell renal cell carcinoma： a prospective, controlled, phase II study中文标题：派安普利单抗辅助治疗极高危透明细胞肾细胞癌的疗效和安全性：一项前瞻性、对照、II期研究讲者：顾良友教授中国人民解放军总医院摘要号：2623P英文标题：CLEAR-IT： Preliminary Results from a Phase II Study Evaluating Cadonilimab Plus Lenvatinib in Previously Immunotherapy-Treated Advanced/Metastatic Clear Cell Renal Cell Carcinoma (ccRCC)中文标题：CLEAR-IT：卡度尼利单抗联合仑伐替尼治疗既往接受过免疫疗法治疗的晚期/转移性透明细胞肾细胞癌（ccRCC）的II期临床研究的初步结果讲者：黄吉炜教授上海交通大学医学院附属仁济医院摘要号：2630P英文标题：Single-Nucleus Atlas of Collecting Duct Carcinoma Reveals Cellular Heterogeneity, Malignant Evolution, and Immunosuppressive Microenvironment中文标题：集合管癌单核图谱揭示细胞异质性、恶性演化和免疫抑制微环境讲者：Linhui Zhang 中国上海摘要号：2634P英文标题：Remodeling of the tumor microenvironment by PD-1 blockade plus tyrosine kinase inhibitor in advanced renal cell carcinoma中文标题：PD-1阻断联合酪氨酸激酶抑制剂对晚期肾细胞癌肿瘤微环境的重塑讲者：Qiyang Liang 中国北京摘要号：2638P英文标题：Anlotinib plus everolimus as first-line treatment for advanced non–clear cell renal cell carcinoma：1 year updated results from UC-001, a single-center, single-arm, phase II trial中文标题：安罗替尼联合依维莫司作为晚期非透明细胞肾细胞癌的一线治疗：单中心、单组、II 期临床试验UC-001的1年更新结果讲者：徐文浩教授复旦大学附属肿瘤医院摘要号：2640P英文标题：A multimodal multifaceted artificial intelligence model for diagnosing renal masses using contrast-enhanced computed tomography and laboratory parameters： A multicenter study中文标题：基于增强CT和实验室参数诊断肾脏肿块的多模态多方面人工智能模型：一项多中心研究讲者：Axide Haoni 中国上海摘要号：2642P英文标题：Immunosuppressive TREM2⁺ Tumor-Associated Macrophages Potentiate Immunotherapy Responsiveness in Patients with Clear Cell Renal Cell Carcinoma (ccRCC)中文标题：免疫抑制TREM2⁺肿瘤相关巨噬细胞增强透明细胞肾细胞癌（ccRCC）患者的免疫治疗反应讲者：Jiahao Wang 中国上海摘要号：2648P英文标题：Phase II Clinical Study of the Safety and Efficacy of Sintilimab in Combination with Axitinib and Stereotactic Radiotherapy in the Treatment of Local-regional Recurrent Renal Cell Carcinoma中文标题：信迪利单抗联合阿昔替尼及立体定向放射治疗治疗局部区域复发性肾细胞癌的安全性和有效性的II期临床研究讲者：Ruiqi Liu 中国广州摘要号：2653eP英文标题： Why Is TFE3 Prone to Breakage in TFE3-Rearranged Renal Cell Carcinoma? A Perspective on Non-Canonical DNA Structures and Their Stability中文标题：为什么TFE3在TFE3重排的肾细胞癌中容易断裂？非经典DNA结构及其稳定性的视角讲者：Xiaopo Zhang 中国南京摘要号：2654eP英文标题： Multi-Omic Analysis of Collecting Duct Carcinoma Reveals Enhanced Ribosome Biogenesis as a Driver of Malignant Metastasis and Proliferation中文标题：集合管癌的多组学分析揭示增强的核糖体生物合成是恶性转移和增殖的驱动因素讲者：Linhui Zhang 中国上海摘要号：2657eP英文标题： Deciphering Immune microenvironment landscape in renal cell carcinoma with different regimen：a single cell RNA sequencing study中文标题：解读不同治疗方案肾细胞癌的免疫微环境：单细胞RNA测序研究讲者：Jiahao Wang 中国上海摘要号：2660eP英文标题： Clinical Value of Dynamic ctDNA-MRD Monitoring in Advanced mRCC Patients Receiving TKIs Plus PD-1 Inhibitor Therapy中文标题：动态ctDNA-MRD监测在接受TKI联合PD-1抑制剂治疗的晚期mRCC患者中的临床价值讲者：黄吉炜教授上海交通大学医学院附属仁济医院摘要号：2661eP英文标题： Multi-omics Uncovers the Molecular Machinery Underlying Autophagic Regulation Leading to Metastasis in Chromophobe Renal Cell Carcinoma中文标题：多组学揭示导致嫌色性肾细胞癌转移的自噬调控的分子机制讲者：Jiayi Lu 中国上海摘要号：2670eP英文标题： SPP1+ Tumor-associated Macrophages Drive Immunotherapy Resistance via CD8+ T Cell Dysfunction in Clear Cell Renal Cell Carcinoma中文标题：SPP1+肿瘤相关巨噬细胞通过透明细胞肾细胞癌中的CD8+T细胞功能障碍驱动免疫治疗耐药性讲者：Wenbin Jiang 中国上海摘要号：2675eP英文标题： Shared Genetic and Proteomic Architecture Between Metabolic Syndrome and Renal Cell Carcinoma Highlights Insulin Resistance-CKD Axis中文标题：代谢综合征与肾细胞癌之间共享的遗传和蛋白质组学结构突出了胰岛素抵抗-CKD轴讲者：Chenhao Xu 中国成都摘要号：2676eP英文标题： Schwann Cell-Mediated Mechanisms in Renal Cell Carcinoma Metastasis at the Tumor Border Microenvironment中文标题：肾细胞癌在肿瘤边界微环境中转移的施万细胞介导机制讲者：Qiang Song 中国上海摘要号：2679eP英文标题：CT-based intratumoral vascular feature reveals a transcriptomic signature predictive of prognosis and treatment stratification in renal cell carcinoma中文标题：基于CT的肿瘤内血管特征揭示了可预测肾细胞癌预后和治疗分层的转录组特征讲者：Zilin Wang 中国成都相关研究信息来自ESMO官网。本文主要按照肿瘤类型和摘要号进行排序，如有遗漏和错误，欢迎留言~（来源：《肿瘤瞭望-泌尿时讯》编辑部）声明凡署名原创的文章版权属《肿瘤瞭望》所有，欢迎分享、转载。本文仅供医疗卫生专业人士了解最新医药资讯参考使用，不代表本平台观点。该等信息不能以任何方式取代专业的医疗指导，也不应被视为诊疗建议，如果该信息被用于资讯以外的目的，本站及作者不承担相关责任。

临床结果临床2期临床3期

2025-07-19

·药事纵横

三喜临门！恒瑞医药 3款单抗获批临床

声明：因水平有限，错误不可避免，或有些信息非最及时，欢迎留言指出。本文仅作医疗健康相关药物介绍，非治疗方案推荐（若涉及）;本文不构成任何投资建议。7月17日，恒瑞医药发布公告，公司收到国家药品监督管理局核准签发关于SHR-8068注射液、阿得贝利单抗注射液、贝伐珠单抗注射液和甲磺酸阿帕替尼片的《药物临床试验批准通知书》，将于近期开展临床试验。SHR-8068 注射液是公司引进的一款全人源抗CTLA-4单克隆抗体，可增强抗肿瘤免疫效应。目前全球共有两款同类产品获批上市，分别是伊匹木单抗和替西木单抗。经查询，2024年伊匹木单抗和替西木单抗全球销售额合计约为32.71 亿美元。截至目前，SHR-8068注射液相关项目累计研发投入约2.14亿元。阿得贝利单抗注射液是公司自主研发的人源化抗PD-L1单克隆抗体，能通过特异性结合PD-L1分子从而阻断导致肿瘤免疫耐受的PD-1/PD-L1通路，重新激活免疫系统的抗肿瘤活性，从而达到治疗肿瘤的目的。公司阿得贝利单抗注射液（商品名：艾瑞利）已于2023年3月获批上市，获批的适应症为与卡铂和依托泊苷联合用于广泛期小细胞肺癌患者的一线治疗。国外有同类产品 Atezolizumab （商品名：Tecentriq）、Avelumab(商品名：Bavencio)和 Durvalumab(商品名：Imfinzi)于美国获批上市销售，其中 Atezolizumab 和 Durvalumab 已在中国获批上市。国内有康宁杰瑞/思路迪药业的恩沃利单抗、基石药业的舒格利单抗和正大天晴药业的贝莫苏拜单抗等同类产品获批上市。2024年Atezolizumab、Avelumab 和 Durvalumab 全球销售额合计约为96.48 亿美元。截至目前，阿得贝利单抗注射液相关项目累计研发投入约8.87亿元。贝伐珠单抗是一种人源化抗VEGF单克隆抗体，由中外制药和罗氏的子公司基因泰克合作开发，2004年由美国食品药品监督管理局批准上市，商品名为 Avastin（安维汀），目前已在中国和全球多个国家上市销售。公司的贝伐珠单抗注射液已于2021年6月获批上市，国内目前有多个贝伐珠单抗注射液获批上市。经查询，2024年贝伐珠单抗全球销售额约为56.55亿美元。截至目前，贝伐珠单抗注射液相关项目累计研发投入约3.45亿元。除此之外，近期，恒瑞医药在减肥药上也获得积极结果。7月15日，恒瑞医药与Kailera Therapeutics共同宣布HRS9531注射液治疗肥胖或超重3期临床试验（HRS9531-301）获得积极顶线结果。与安慰剂相比，HRS9531（2mg、4mg、6mg）在共同主要终点及关键次要终点上均达到优效性。HRS9531是恒瑞医药自主研发的胰高血糖素样肽1（GLP-1）和葡萄糖依赖性促胰岛素肽（GIP）双重受体激动剂。2024年5月，Kailera Therapeutics以首付款加里程碑付款累计可高达60亿美元，及恒瑞医药获得Kailera19.9%股权的方式，得到HRS9531除大中华区以外的全球范围内开发、生产和商业化独家权利。参考资料：公司公告

上市批准临床3期

2025-07-13

·信狐药迅

两个1类新药：苏州亚盛力胜克拉片和苏州旺山旺水斯美瑞非片获批上市| 新获批(7.7-7.13）

每周药品注册获批数据，分门别类呈现，一目了然。(7.7-7.13）新药上市申请药品名称企业注册分类受理号力胜克拉片苏州亚盛药业有限公司1CXHS2400114力胜克拉片苏州亚盛药业有限公司1CXHS2400113力胜克拉片苏州亚盛药业有限公司1CXHS2400112斯美瑞非片苏州旺山旺水生物医药股份有限公司1CXHS2300087斯美瑞非片苏州旺山旺水生物医药股份有限公司1CXHS2300086斯美瑞非片苏州旺山旺水生物医药股份有限公司1CXHS2300085新药临床申请药品名称企业注册分类受理号DZD8586片迪哲(江苏)医药股份有限公司1CXHL2500453注射用JJH201601脂质体江苏吉贝尔药业股份有限公司1CXHL2500448CMS-D001片海南德镁医药科技有限责任公司1CXHL2500442CMS-D001片海南德镁医药科技有限责任公司1CXHL2500441注射用HRS8179北京盛迪医药有限公司1CXHL2500436MDI-1228_mesylate凝胶迈英诺医药科技(珠海)有限公司1CXHL2500435MDI-1228_mesylate凝胶迈英诺医药科技(珠海)有限公司1CXHL2500434MDI-1228_mesylate凝胶迈英诺医药科技(珠海)有限公司1CXHL2500433MDI-1228_mesylate凝胶迈英诺医药科技(珠海)有限公司1CXHL2500432SYN608片杭州圣域生物医药科技有限公司1CXHL2500430SYN608片杭州圣域生物医药科技有限公司1CXHL2500429G201-Na胶囊石家庄以岭药业股份有限公司1CXHL2500425G201-Na胶囊石家庄以岭药业股份有限公司1CXHL2500424PTT-621片北京炎明生物科技有限公司1CXHL2500399PTT-621片北京炎明生物科技有限公司1CXHL2500398GD-19乳状注射液天津谷堆生物医药科技有限公司2.1CXHL2500385OLP-210片深圳奥礼生物科技有限公司2.2CXHL2500423OLP-210片深圳奥礼生物科技有限公司2.2CXHL2500422OLP-210片深圳奥礼生物科技有限公司2.2CXHL2500421ACIERT缓释片吉林天衡药业有限公司2.2CXHL2500412ACIERT缓释片吉林天衡药业有限公司2.2CXHL2500411甲磺酸阿帕替尼片江苏恒瑞医药股份有限公司2.4CXHL2500419重组带状疱疹疫苗(CHO细胞)安徽智飞龙科马生物制药有限公司1.3CXSL2500282IBI130信达生物制药(苏州)有限公司1CXSL2500366注射用BG-C477广州百济神州生物制药有限公司1CXSL2500358重组抗CD19m-CD3抗体注射液天劢源和生物医药(上海)有限公司1CXSL2500355LP-005 注射液天辰生物医药(苏州)有限公司1CXSL2500354FG-B901注射液明济生物制药(北京)有限公司1CXSL2500352FL115注射液苏州复融生物技术有限公司1CXSL2500350注射用BGB-B3227广州百济神州生物制药有限公司1CXSL2500347注射用YL242苏州宜联生物医药有限公司1CXSL2500343IMD101 注射液上海英脉德医疗科技有限公司1CXSL2500339BBT001注射液杉竹曜(北京)生物医药科技有限公司1CXSL2500342注射用DB-1311映恩生物制药(苏州)有限公司1CXSL2500337YOLT-101注射液尧唐(南京)生物科技有限公司1CXSL2500313AL-001眼用注射液北京安龙合生药业有限公司1CXSL2500301DMR2301注射液上海多米瑞生物技术有限公司1CXSL2500308人脐带间充质干细胞注射液源品细胞生物科技集团有限公司1CXSL2500297注射用RGL-232上海瑞宏迪医药有限公司1CXSL2500295CRG-B191注射液上海科锐克医药科技有限公司1CXSL2500293QX029N注射液江苏荃信生物医药股份有限公司1CXSL2500288MSLN-CAR-T细胞注射液上海怡豪生物科技有限公司1CXSL2500281依沃西单抗注射液康方赛诺医药有限公司2.2CXSL2500345SHR-8068注射液苏州盛迪亚生物医药有限公司2.2CXSL2500340SHR-8068注射液苏州盛迪亚生物医药有限公司2.2CXSL2500338贝伐珠单抗注射液苏州盛迪亚生物医药有限公司2.2CXSL2500336阿得贝利单抗注射液上海盛迪医药有限公司2.2CXSL2500335仿制药申请药品名称企业注册分类受理号盐酸肾上腺素注射液成都瑞尔医药科技有限公司3CYHS2400548磷酸奥司他韦干混悬剂福建省闽东力捷迅药业股份有限公司3CYHS2400421二羟丙茶碱注射液安徽美来药业股份有限公司3CYHS2400281吡拉西坦注射液湖南赛隆药业(长沙)有限公司3CYHS2400261吡拉西坦注射液湖南赛隆药业(长沙)有限公司3CYHS2400260富马酸酮替芬口服溶液浙江易泽达医药科技有限公司3CYHS2303277氯化钾颗粒山西皇城相府药业股份有限公司3CYHS2303100氯化钾颗粒山西皇城相府药业股份有限公司3CYHS2303099头孢丙烯干混悬剂海南葫芦娃药业集团股份有限公司3CYHS2302198福多司坦片天方药业有限公司3CYHS2302051卡络磺钠注射液南京恩泰医药科技有限公司3CYHS2301863卡络磺钠注射液南京恩泰医药科技有限公司3CYHS2301862注射用水溶性维生素辽宁海思科制药有限公司3CYHS2301315氨溴特罗口服溶液北京韩美生物科技有限公司3CYHS2301124艾拉莫德片四川国为制药有限公司4CYHS2401588瑞舒伐他汀依折麦布片(I)浙江诺得药业有限公司4CYHS2401540注射用盐酸地尔硫䓬山东豪瑞恩制药有限公司4CYHS2401285氯化钾氯化钠注射液石家庄四药有限公司4CYHS2401230氯化钾氯化钠注射液石家庄四药有限公司4CYHS2401229贝前列素钠片江苏和晨药业有限公司4CYHS2401140盐酸决奈达隆片齐鲁制药有限公司4CYHS2401042普拉替尼胶囊基石药业(苏州)有限公司4CYHS2401036地夸磷索钠滴眼液苏州朗科生物技术股份有限公司4CYHS2400985左氧氟沙星氯化钠注射液辽宁民康制药有限公司4CYHS2400843尼可地尔片北京四环科宝制药股份有限公司4CYHS2400774阿哌沙班片浙江永宁药业股份有限公司4CYHS2400729磷酸奥司他韦胶囊吉林开曼药业有限公司4CYHS2400737注射用头孢唑肟钠广州合和医药有限公司4CYHS2400569盐酸尼卡地平注射液南京锐志生物医药有限公司4CYHS2400566氨氯地平阿托伐他汀钙片湖南威特制药股份有限公司4CYHS2400461聚乙二醇钠钾散四川科伦药业股份有限公司4CYHS2400408盐酸尼卡地平注射液浙江华海药业股份有限公司4CYHS2400383培哚普利氨氯地平片(I)天津力生制药股份有限公司4CYHS2400310培哚普利氨氯地平片(III)天津力生制药股份有限公司4CYHS2400309琥珀酸美托洛尔缓释片浙江华海药业股份有限公司4CYHS2303470二甲双胍恩格列净片(I)湖南及正医药科技有限公司4CYHS2303454注射用磷酸特地唑胺江苏正大丰海制药有限公司4CYHS2303356盐酸莫西沙星滴眼液扬州中宝药业股份有限公司4CYHS2303323孟鲁司特钠颗粒浙江易泽达医药科技有限公司4CYHS2303311贝美素噻吗洛尔滴眼液杭州民生药业股份有限公司4CYHS2303101盐酸乌拉地尔天方药业有限公司CYHS2360899四价流感病毒裂解疫苗浙江天元生物药业有限公司3.3CXSS2300101盐酸米诺环素泡沫剂上海则正医药科技股份有限公司4CYHL2500089盐酸米诺环素泡沫剂深圳珐玛易药品科技有限公司4CYHL2500087琥珀酰明胶电解质醋酸钠注射液四川太平洋药业有限责任公司4CYHL2500081噻托溴铵吸入粉雾剂艾特美(苏州)医药科技有限公司4CYHL2500077吸附破伤风疫苗远大赛威信生命科学(南京)有限公司3.3CXSL2500296进口申请药品名称企业注册分类受理号褪黑素颗粒Nobelpharma Co., Ltd.5.1JXHS2400013褪黑素颗粒Nobelpharma Co., Ltd.5.1JXHS2400012BPC2001注射液BioPhoenix Co., Ltd.1JXHL2500100BMS-986435片Bristol-Myers Squibb Company1JXHL2500086BMS-986435片Bristol-Myers Squibb Company1JXHL2500085BMS-986435片Bristol-Myers Squibb Company1JXHL2500084Capivasertib片AstraZeneca AB2.4JXHL2500109Capivasertib片AstraZeneca AB2.4JXHL250010821价肺炎球菌多糖结合疫苗Sanofi Pasteur Inc.1.4JXSL2500058Mezagitamab注射剂Takeda Development Center Americas, Inc.1JXSL2500066SAR442970注射液Sanofi-Aventis Recherche & Développement1JXSL2500062SAR442970注射液Sanofi-Aventis Recherche & Développement1JXSL2500059中药相关申请药品名称企业注册分类受理号香芩解热颗粒云南方盛融和药业有限公司1.1CXZL2500024健脾解毒丸新疆维吾尔自治区中医医院1.1CXZL2500021注：橙色字体部分结论为不批准或收到通知件；

上市批准疫苗

100 项与阿得贝利单抗相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB16412

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
广泛期小细胞肺癌	中国	上海盛迪医药有限公司	2023-02-28

未上市

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
肌层浸润性膀胱癌	临床3期	中国	苏州盛迪亚生物医药有限公司	2025-04-25
晚期肝细胞癌	临床3期	中国	苏州盛迪亚生物医药有限公司	2024-10-28
非鳞状非小细胞肺癌	临床3期	中国	上海盛迪医药有限公司	2024-03-29
非鳞状非小细胞肺癌	临床3期	中国	苏州盛迪亚生物医药有限公司	2024-03-29
局限期小细胞肺癌	临床3期	中国	江苏恒瑞医药股份有限公司	2021-01-20
非小细胞肺癌IIIB期	临床3期	中国	江苏恒瑞医药股份有限公司	2020-07-14
可切除非小细胞肺癌	临床3期	中国	江苏恒瑞医药股份有限公司	2020-07-10
复发性头颈部鳞状细胞癌	临床2期	中国	苏州盛迪亚生物医药有限公司	2025-07-11
不能切除的胆道癌	临床2期	-	江苏恒瑞医药股份有限公司	2025-07-10
肿瘤转移	临床2期	中国	上海恒瑞医药有限公司	2025-07-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT06765616 (ESMO_GI2025)	临床2期	局部晚期直肠癌辅助 pMMR	31	Adebrelimab	鏇築簾艱鹽積淵鹹淵蓋(鏇遞鬱壓鏇繭獵範構蓋) = 願遞繭簾淵網築鹹鏇範製鹽觸網範鑰選窪繭壓 (築積糧鏇衊網願齋繭膚 ) 更多	积极	2025-07-03
NCT04303988 (ASCO2025) 人工标引	临床2期	三阴性乳腺癌	35	Adebrelimab + Bevacizumab + Cisplatin/Carboplatin	淵築醖顧簾獵簾鑰齋選(淵築廠簾廠繭餘夢鏇範) = 憲觸範鏇鏇顧鹽鏇鹹醖餘顧淵範鬱築遞膚淵壓 (繭願蓋選餘鹽糧觸膚鹹 ) 更多	积极	2025-05-30
ChiCTR2300078869 (ASCO2025)	临床2期	肝内胆管癌二线 HBV infection history	10	Adebrelimab + Lenvatinib	夢鑰窪憲製築艱鹽襯憲(憲願壓選齋積網艱積襯) = 鬱淵糧獵顧廠憲願壓衊製網構遞糧壓糧鬱遞遞 (簾築繭選鹹觸艱製蓋遞 ) 更多	积极	2025-05-30
NCT06016413 (Phase II study of adebrelimab plus carboplatin and albumin-bound taxanol in head and neck squamous cell carcinoma, ASCO2025)	临床2期	局部晚期头颈部鳞状细胞癌新辅助 PD-L1	30	Adebrelimab + Carboplatin + Albumin-bound Paclitaxel	壓窪築簾鬱獵鏇壓繭糧(窪鹹醖膚範夢鏇醖淵鹹) = 艱積壓憲鹹蓋淵糧鹽範鬱範艱窪夢糧遞醖鏇選 (糧襯齋觸廠衊繭鹽鹹襯 ) 更多	积极	2025-05-30
NCT06299371 (ESMO_ELCC2025)	临床2期	EGFR突变的非小细胞肺癌新辅助 \| 辅助 EGFR mutations	-	Adebrelimab + Albumin-bound paclitaxel + Carboplatin/Cisplatin	顧夢窪鹽築願醖積蓋醖(艱顧願憲鹹顧遞廠膚鏇) = 網鹹艱鏇糧築淵憲鏇糧蓋廠製廠夢繭願網蓋醖 (網醖網鹽範窪遞鏇網糧 ) 更多	-	2025-03-26
CAPSTONE-1 (ESMO_ELCC2025)	N/A	广泛期小细胞肺癌	75	Adebrelimab-based therapy	鏇選窪餘襯齋襯淵鬱顧(齋構遞淵鬱夢憲網鏇衊) = 蓋鹽壓獵構淵繭壓積構餘遞觸顧獵觸夢獵積窪 (遞願窪壓壓憲觸夢齋鏇, 54.8 ~ 77.1) 更多	积极	2025-03-26
ChiCTR2300069179 (ASCO_GI2025) 人工标引	临床2期	局部晚期食管鳞状细胞癌辅助 \| 新辅助	36	Adebrelimab + Paclitaxel + Cisplatin	襯鹽選襯願遞簾膚鬱顧(餘壓鬱廠網鑰網網襯構) = 餘窪襯鏇築選壓構鑰範蓋鬱範糧衊鑰蓋繭窪壓 (構膚積窪簾糧壓遞憲鬱 ) 更多	积极	2025-01-23
NCT06178211 (ASCO_GI2025) 人工标引	临床2期	局部晚期食管鳞状细胞癌新辅助	36	Adebrelimab + Chemotherapy	網醖壓遞艱襯積憲選獵(衊壓簾淵製築觸簾夢齋) = 襯膚範獵網簾繭淵蓋廠膚範築觸壓醖簾衊構製 (鹽糧範糧壓築憲淵範範, 23.1 ~ 56.5) 更多	积极	2025-01-23
NCT06178211 (ASCO_GI2025) 人工标引	临床2期	局部晚期食管鳞状细胞癌新辅助	36	Adebrelimab + Chemotherapy (Surgery)	網醖壓遞艱襯積憲選獵(衊壓簾淵製築觸簾夢齋) = 鬱廠積遞餘鏇顧顧選齋膚範築觸壓醖簾衊構製 (鹽糧範糧壓築憲淵範範, 24.6 ~ 59.3) 更多	积极	2025-01-23
ADBL-LC-001 (ESMO_IO2024) 人工标引	N/A	小细胞肺癌一线	143	Adebrelimab (ES-SCLC)	願鬱窪顧餘築製醖鑰鹽(鑰艱衊餘願淵鹹鑰淵窪) = 願憲遞鏇廠構鏇繭鬱顧築鏇簾淵齋製艱鏇淵鑰 (積構遞鬱憲憲獵製蓋觸, 10.0 ~ 14.9) 更多	积极	2024-12-12
ADBL-LC-001 (ESMO_IO2024) 人工标引	N/A	小细胞肺癌一线	143	Adebrelimab (LS-SCLC)	願鬱窪顧餘築製醖鑰鹽(鑰艱衊餘願淵鹹鑰淵窪) = 襯構餘壓蓋鏇網醖構網築鏇簾淵齋製艱鏇淵鑰 (積構遞鬱憲憲獵製蓋觸, 13.7 ~ NA) 更多	积极	2024-12-12
ESMO_IO2024 人工标引	N/A	广泛期小细胞肺癌一线	188	Adebrelimab-based regimen	範觸鏇艱糧鏇醖醖艱膚(願顧窪糧顧餘鏇艱製醖) = 構構襯繭遞鏇鹽膚蓋鬱鏇醖簾憲夢糧糧願遞遞 (鏇積鏇遞鏇鹹製選觸鹽 ) 更多	积极	2024-12-12