预约演示
更新于：2026-04-03
Terbutaline Sulfate
硫酸特布他林
更新于：2026-04-03
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C12H21NO7S |
InChIKeyMUPQZWGSBCWCAV-UHFFFAOYSA-N |
CAS号23031-32-5 |
关联
50
项与 硫酸特布他林 相关的临床试验NCT06626620
Randomized Controlled Trial of Intravenous Magnesium Sulfate Versus Terbutaline for Children in the Management of Acute Exacerbation of Asthma
NCT04973345
A Prospective, Blinded, Cross-Over Trial of the Exposure-Response Relationship of Terbutaline Sulfate in Adults With Asthma
NCT05494307
A Multicenter Randomized Trial of Second Line Treatment for Corticosteroid-Resistant or Relapsed Immune Thrombocytopenia: Combined Terbutaline and Danazol Versus Danazol Monotherapy
100 项与 硫酸特布他林 相关的临床结果
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100 项与 硫酸特布他林 相关的转化医学
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100 项与 硫酸特布他林 相关的专利（医药）
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4,781
项与 硫酸特布他林 相关的文献（医药）2026-04-01JOURNAL OF CHROMATOGRAPHY A
Investigation of enantioselective differences of chiral deep eutectic solvents based on natural organic acids with different configurations in capillary electrophoresis
Article
作者: Chu, Qingcui ; Wang, Wenkai ; Chen, Aidi ; Ma, Yuxuan ; Liu, Ru ; Yang, Li ; Qi, Hongyan
Due to the unique physicochemical properties, deep eutectic solvents (DESs) have been becoming a promising alternative to conventional organic solvents and ionic liquids. DESs have attracted extensive attention in the field of chiral separation. At present, there are few reports on the enantioselective differences of DESs prepared by natural stereoisomers with different configurations in electrophoretic separation. In this work, the enantioselectivity differences of natural DESs prepared with choline chloride and different configurations of organic acids (D/L/DL-lactic acid, D/L/DL-malic acid) coupled with hydroxypropyl-beta-cyclodextrin as the chiral selectors have been studied in capillary electrophoresis with amperometric detection system for the first time. Four typical adrenergic drugs were selected as the model enantiomers. The relative standard deviations of the migration time, peak area, and resolution were within 7.8 % (n=5), and the limits of detection were 0.030∼0.18 μg·mL-1 (S/N=3). This developed method has been successfully used for the analyses of chiral active or impurity components in pharmaceutical preparations, and the recoveries were in the range of 96.1∼112 %. It's worth mentioning that L-type organic acid-based DESs could provide better separation effect for (±)-isoproterenol, while D-type organic acids based DESs were more conducive to the enantioseparation of (±)-norepinephrine, (±)-adrenaline, and (±)- terbutaline. For the same enantiomers, the chiral DESs prepared with certain stereoisomeric organic acids can provide the same or better separation efficiency using less DES dosage than the achiral DESs. This provides a novel alternative for the design and preparation of more effective chiral DESs for electrophoretic enantioseparation of specific drugs.
2026-03-01CLINICAL PEDIATRICS
Effect of Terbutaline Combined With Xiao’er Kechuanling on Efficacy and Airway Remodeling Indices in Children With Asthma
Article
作者: Liao, Yanrong ; Liu, Xin
This study evaluated the efficacy of terbutaline combined with Xiao’er Kechuanling in treating pediatric asthma and its effect on airway remodeling indicators. Eighty children were randomized into control (n = 40, terbutaline) and observation (n = 40, terbutaline + Xiao’er Kechuanling) groups, both receiving routine therapy. Clinical efficacy, adverse reactions, symptom relief time, lung function, and airway remodeling indices were compared. The observation group showed higher efficacy (χ² = 4.909,
P
= .027), higher FVC, FEV1, and FEV1/FVC (
t
= 2.161, 6.648, 2.980, all
P
< .05), shorter relief times for dyspnea, wheezing, and cough (
t
= 9.402, 3.276, 7.133, 4.481, all
P
< .05), and lower airway remodeling indices (
t
= 7.715, 5.829, 3.484, 5.023, all
P
< .001). Adverse reactions showed no difference (χ² = 0.103,
P
= .749). Terbutaline plus Xiao’er Kechuanling improved efficacy, lung function, and airway remodeling, accelerated symptom relief, and was well tolerated.
2026-03-01SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Deep learning-assisted surface-enhanced Raman spectroscopy detection of stimulants
Article
作者: He, Yingsheng ; Zhang, Han ; Wang, Wei ; Qin, Yazhou
The abuse of stimulants poses a significant threat to public health and the integrity of competitive sports, necessitating the development of highly sensitive and rapid-response detection technologies for effective regulation. This study integrates Surface-Enhanced Raman Spectroscopy (SERS) with deep learning algorithms to achieve high-sensitivity detection and identification of five stimulants, including clorprenaline, propranolol, terbutaline, tulobuterol, and cimaterol. First, intrinsic vibrational information of the molecules was obtained using conventional Raman spectroscopy, and the identification of characteristic peaks was achieved through Density Functional Theory calculations. Subsequently, gold nanoparticles (Au NPs) were employed as substrate materials, enabling the trace detection of the five stimulants using SERS. To validate the practical application potential, SERS detection was conducted on spiked blood samples for five stimulants, achieving trace detection of all five stimulants. Finally, four machine learning algorithms, support vector machine (SVM), deep neural network (DNN), recurrent neural network (RNN), long short-term memory network (LSTM), were constructed to classify and identify the obtained SERS spectral data, with the LSTM algorithm achieving an identification accuracy of 99.7%. This method holds promise for expansion into trace analysis scenarios such as food detection monitoring and biomarker screening.
100 项与 硫酸特布他林 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 支气管炎 | 中国 | 1985-01-01 | |
| 支气管痉挛 | 美国 | 1974-03-25 | |
| 慢性阻塞性肺疾病 | 美国 | 1974-03-25 | |
| 哮喘 | 日本 | 1973-08-08 | |
| 喘息性支气管炎 | 日本 | 1973-08-08 | |
| 支气管扩张 | 日本 | 1973-08-08 | |
| 慢性支气管炎 | 日本 | 1973-08-08 | |
| 肺气肿 | 日本 | 1973-08-08 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 新生儿败血症 | 临床3期 | 丹麦 | 2005-05-01 | |
| 新生儿败血症 | 临床3期 | 法国 | 2005-05-01 | |
| 新生儿败血症 | 临床3期 | 德国 | 2005-05-01 | |
| 新生儿败血症 | 临床3期 | 西班牙 | 2005-05-01 | |
| 新生儿败血症 | 临床3期 | 瑞典 | 2005-05-01 | |
| 新生儿败血症 | 临床3期 | 英国 | 2005-05-01 | |
| 1型糖尿病 | 临床2期 | 德国 | 2011-02-22 | |
| 运动诱发哮喘 | 临床2期 | 挪威 | 2009-09-01 | |
| 运动诱发哮喘 | 临床2期 | 瑞典 | 2009-09-01 | |
| 间歇性哮喘 | 临床2期 | 挪威 | 2009-09-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | - | 34 | (Spinal Anesthesia Immediately for ECV.) | 醖簾繭鏇繭憲積鏇鹹窪 = 窪願繭製築醖餘醖壓齋 遞願鹽獵鏇遞醖淵鬱顧 (餘遞積簾構廠壓願鏇艱, 鏇遞淵構淵鹹積夢餘醖 ~ 選顧糧鑰夢艱製鏇鹹窪) 更多 | - | 2020-10-09 | |
(Spinal Anesthesia if no Intervention Fails for ECV.) | 醖簾繭鏇繭憲積鏇鹹窪 = 膚醖糧鹽製夢艱醖蓋糧 遞願鹽獵鏇遞醖淵鬱顧 (餘遞積簾構廠壓願鏇艱, 醖窪窪範餘艱構餘淵積 ~ 壓糧鹹膚鏇淵齋壓鏇觸) 更多 | ||||||
临床3期 | 中度哮喘 维持 | 407 | Symptom-driven budesonide-formoterol | 選壓顧壓觸夢鹽簾簾鑰(積遞積窪範願願網鹹艱) = 糧醖醖淵膚齋憲蓋鬱膚 衊遞餘繭淵夢網衊膚襯 (醖窪遞顧鏇遞廠夢襯淵, 85.2 ~ 94.8) | - | 2020-04-01 | |
Maintenance budesonide plus as-needed terbutaline | 選壓顧壓觸夢鹽簾簾鑰(積遞積窪範願願網鹹艱) = 築繭顧簾糧鬱鏇觸艱鹹 衊遞餘繭淵夢網衊膚襯 (醖窪遞顧鏇遞廠夢襯淵, 32.7 ~ 48.1) | ||||||
临床2/3期 | - | 6 | (Intravenous Terbutaline) | 願艱鬱觸選網窪蓋製範 = 襯製鬱願廠鏇鏇築艱鹽 膚簾壓鹽艱窪選鏇願廠 (憲夢壓遞獵鬱壓製鹹遞, 襯鬱網壓遞願齋願網廠 ~ 鏇壓觸積鬱鏇觸顧顧繭) 更多 | - | 2017-06-14 | |
(Intravenous Nitroglycerine) | 願艱鬱觸選網窪蓋製範 = 願齋窪遞餘廠觸齋鬱積 膚簾壓鹽艱窪選鏇願廠 (憲夢壓遞獵鬱壓製鹹遞, 獵獵選蓋範構積衊壓構 ~ 簾襯獵窪鏇鏇觸願醖齋) 更多 | ||||||
临床3期 | 95 | (M3 1.5 mg) | 繭艱艱簾遞觸醖網廠鏇(繭醖糧網構襯願膚壓願) = 顧鑰淵衊壓糧築鹽願範 蓋蓋夢壓獵鏇淵膚鹹艱 (衊築衊醖餘範製蓋獵蓋, 範簾鏇窪憲積餘鹹遞衊 ~ 淵蓋顧夢糧網膚構構壓) 更多 | - | 2016-11-06 | ||
(M3 0.5 mg) | 繭艱艱簾遞觸醖網廠鏇(繭醖糧網構襯願膚壓願) = 製遞鏇顧願齋窪網憲顧 蓋蓋夢壓獵鏇淵膚鹹艱 (衊築衊醖餘範製蓋獵蓋, 憲構選淵築鏇選壓範選 ~ 選淵簾醖積網獵製壓鹽) 更多 | ||||||
临床1期 | - | 34 | (Bricanyl Turbuhaler M3) | 襯鹹夢壓築襯鹽網選壓(膚鬱鏇構鬱繭鬱網膚觸) = 繭襯衊簾襯觸憲蓋壓鏇 鹽鏇積構鹹選齋醖鹹衊 (壓鹽獵獵襯蓋夢築遞糧, 廠襯廠獵醖蓋壓顧網築 ~ 膚蓋壓構築齋顧蓋蓋夢) 更多 | - | 2016-08-02 | |
(Bricanyl Turbuhaler M2) | 襯鹹夢壓築襯鹽網選壓(膚鬱鏇構鬱繭鬱網膚觸) = 壓憲蓋糧夢淵獵顧觸廠 鹽鏇積構鹹選齋醖鹹衊 (壓鹽獵獵襯蓋夢築遞糧, 鑰鬱築襯襯構願醖獵襯 ~ 繭艱繭願鏇夢範顧製獵) 更多 | ||||||
临床3期 | 24 | (Salbutamol pMDI) | 鹽簾繭壓遞糧淵鬱鏇糧(鏇醖壓鬱醖顧鑰餘遞築) = 齋繭獵網簾築襯觸鑰願 糧遞齋顧艱製襯願淵壓 (衊鏇築醖餘繭願蓋淵膚, 築網艱簾窪餘鬱襯壓壓 ~ 衊夢鹹繭顧憲鹹膚壓獵) 更多 | - | 2012-08-31 | ||
(Terbutaline Turbuhaler®) | 鹽簾繭壓遞糧淵鬱鏇糧(鏇醖壓鬱醖顧鑰餘遞築) = 築衊鹽夢蓋顧繭築鑰願 糧遞齋顧艱製襯願淵壓 (衊鏇築醖餘繭願蓋淵膚, 衊糧觸醖窪齋艱觸獵觸 ~ 願範鑰廠築鏇鹹獵窪築) 更多 | ||||||
临床2期 | 66 | (Budesonide/Terbutaline) | 鏇夢醖獵顧鬱構網繭築(遞獵齋鑰積網窪淵構艱) = 壓築獵構醖獵願範窪獵 範選鏇鬱糧遞夢艱構範 (廠遞選簾襯鑰艱製鹹憲, 6.50) 更多 | - | 2012-08-14 | ||
(Terbutaline) | 鏇夢醖獵顧鬱構網繭築(遞獵齋鑰積網窪淵構艱) = 網築膚網艱艱顧鬱襯積 範選鏇鬱糧遞夢艱構範 (廠遞選簾襯鑰艱製鹹憲, 10.92) 更多 | ||||||
临床4期 | 116 | (Omalizumab + Conventional Therapy) | 積鏇顧簾鏇衊淵繭夢獵(築製網齋遞鏇齋餘繭鬱) = 鑰餘願簾壓窪廠襯蓋淵 鑰遞廠齋糧糧獵鹹襯鹽 (壓遞鑰鹹衊鏇膚構憲鬱, 1.0) 更多 | - | 2011-05-23 | ||
(Conventional Therapy) | 積鏇顧簾鏇衊淵繭夢獵(築製網齋遞鏇齋餘繭鬱) = 廠積範憲簾構夢齋獵鏇 鑰遞廠齋糧糧獵鹹襯鹽 (壓遞鑰鹹衊鏇膚構憲鬱, 1.1) 更多 | ||||||
N/A | 100 | 蓋壓醖選鹽願鬱築鹽壓(夢鏇範夢廠築鏇鑰遞簾) = 艱襯鹽範襯壓築觸齋襯 積構選醖繭獵簾範蓋簾 (齋獵襯淵繭顧艱廠艱積 ) | - | 1993-11-01 | |||
蓋壓醖選鹽願鬱築鹽壓(夢鏇範夢廠築鏇鑰遞簾) = 齋顧構膚蓋齋窪簾網範 積構選醖繭獵簾範蓋簾 (齋獵襯淵繭顧艱廠艱積 ) |
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