预约演示
更新于：2026-02-27
Terbutaline Sulfate
硫酸特布他林
更新于：2026-02-27
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
登录后查看时间轴
结构/序列
分子式C12H21NO7S |
InChIKeyMUPQZWGSBCWCAV-UHFFFAOYSA-N |
CAS号23031-32-5 |
关联
50
项与 硫酸特布他林 相关的临床试验NCT06626620
Randomized Controlled Trial of Intravenous Magnesium Sulfate Versus Terbutaline for Children in the Management of Acute Exacerbation of Asthma
NCT04973345
A Prospective, Blinded, Cross-Over Trial of the Exposure-Response Relationship of Terbutaline Sulfate in Adults With Asthma
NCT05494307
A Multicenter Randomized Trial of Second Line Treatment for Corticosteroid-Resistant or Relapsed Immune Thrombocytopenia: Combined Terbutaline and Danazol Versus Danazol Monotherapy
100 项与 硫酸特布他林 相关的临床结果
登录后查看更多信息
100 项与 硫酸特布他林 相关的转化医学
登录后查看更多信息
100 项与 硫酸特布他林 相关的专利（医药）
登录后查看更多信息
4,716
项与 硫酸特布他林 相关的文献（医药）2026-04-01JOURNAL OF CHROMATOGRAPHY A
Investigation of enantioselective differences of chiral deep eutectic solvents based on natural organic acids with different configurations in capillary electrophoresis
Article
作者: Wang, Wenkai ; Chen, Aidi ; Chu, Qingcui ; Ma, Yuxuan ; Liu, Ru ; Yang, Li ; Qi, Hongyan
Due to the unique physicochemical properties, deep eutectic solvents (DESs) have been becoming a promising alternative to conventional organic solvents and ionic liquids. DESs have attracted extensive attention in the field of chiral separation. At present, there are few reports on the enantioselective differences of DESs prepared by natural stereoisomers with different configurations in electrophoretic separation. In this work, the enantioselectivity differences of natural DESs prepared with choline chloride and different configurations of organic acids (D/L/DL-lactic acid, D/L/DL-malic acid) coupled with hydroxypropyl-beta-cyclodextrin as the chiral selectors have been studied in capillary electrophoresis with amperometric detection system for the first time. Four typical adrenergic drugs were selected as the model enantiomers. The relative standard deviations of the migration time, peak area, and resolution were within 7.8 % (n=5), and the limits of detection were 0.030∼0.18 μg·mL-1 (S/N=3). This developed method has been successfully used for the analyses of chiral active or impurity components in pharmaceutical preparations, and the recoveries were in the range of 96.1∼112 %. It's worth mentioning that L-type organic acid-based DESs could provide better separation effect for (±)-isoproterenol, while D-type organic acids based DESs were more conducive to the enantioseparation of (±)-norepinephrine, (±)-adrenaline, and (±)- terbutaline. For the same enantiomers, the chiral DESs prepared with certain stereoisomeric organic acids can provide the same or better separation efficiency using less DES dosage than the achiral DESs. This provides a novel alternative for the design and preparation of more effective chiral DESs for electrophoretic enantioseparation of specific drugs.
2026-03-01CLINICAL PEDIATRICS
Effect of Terbutaline Combined With Xiao’er Kechuanling on Efficacy and Airway Remodeling Indices in Children With Asthma
Article
作者: Liao, Yanrong ; Liu, Xin
This study evaluated the efficacy of terbutaline combined with Xiao’er Kechuanling in treating pediatric asthma and its effect on airway remodeling indicators. Eighty children were randomized into control (n = 40, terbutaline) and observation (n = 40, terbutaline + Xiao’er Kechuanling) groups, both receiving routine therapy. Clinical efficacy, adverse reactions, symptom relief time, lung function, and airway remodeling indices were compared. The observation group showed higher efficacy (χ² = 4.909,
P
= .027), higher FVC, FEV1, and FEV1/FVC (
t
= 2.161, 6.648, 2.980, all
P
< .05), shorter relief times for dyspnea, wheezing, and cough (
t
= 9.402, 3.276, 7.133, 4.481, all
P
< .05), and lower airway remodeling indices (
t
= 7.715, 5.829, 3.484, 5.023, all
P
< .001). Adverse reactions showed no difference (χ² = 0.103,
P
= .749). Terbutaline plus Xiao’er Kechuanling improved efficacy, lung function, and airway remodeling, accelerated symptom relief, and was well tolerated.
2026-03-01SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Deep learning-assisted surface-enhanced Raman spectroscopy detection of stimulants
Article
作者: He, Yingsheng ; Zhang, Han ; Wang, Wei ; Qin, Yazhou
The abuse of stimulants poses a significant threat to public health and the integrity of competitive sports, necessitating the development of highly sensitive and rapid-response detection technologies for effective regulation. This study integrates Surface-Enhanced Raman Spectroscopy (SERS) with deep learning algorithms to achieve high-sensitivity detection and identification of five stimulants, including clorprenaline, propranolol, terbutaline, tulobuterol, and cimaterol. First, intrinsic vibrational information of the molecules was obtained using conventional Raman spectroscopy, and the identification of characteristic peaks was achieved through Density Functional Theory calculations. Subsequently, gold nanoparticles (Au NPs) were employed as substrate materials, enabling the trace detection of the five stimulants using SERS. To validate the practical application potential, SERS detection was conducted on spiked blood samples for five stimulants, achieving trace detection of all five stimulants. Finally, four machine learning algorithms, support vector machine (SVM), deep neural network (DNN), recurrent neural network (RNN), long short-term memory network (LSTM), were constructed to classify and identify the obtained SERS spectral data, with the LSTM algorithm achieving an identification accuracy of 99.7%. This method holds promise for expansion into trace analysis scenarios such as food detection monitoring and biomarker screening.
224
项与 硫酸特布他林 相关的新闻（医药）2026-02-15
2026-01-30
100 项与 硫酸特布他林 相关的药物交易
登录后查看更多信息
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 支气管炎 | 中国 | 1985-01-01 | |
| 支气管痉挛 | 美国 | 1974-03-25 | |
| 慢性阻塞性肺疾病 | 美国 | 1974-03-25 | |
| 哮喘 | 日本 | 1973-08-08 | |
| 喘息性支气管炎 | 日本 | 1973-08-08 | |
| 支气管扩张 | 日本 | 1973-08-08 | |
| 慢性支气管炎 | 日本 | 1973-08-08 | |
| 肺气肿 | 日本 | 1973-08-08 |
未上市
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 新生儿败血症 | 临床3期 | 丹麦 | 2005-05-01 | |
| 新生儿败血症 | 临床3期 | 法国 | 2005-05-01 | |
| 新生儿败血症 | 临床3期 | 德国 | 2005-05-01 | |
| 新生儿败血症 | 临床3期 | 西班牙 | 2005-05-01 | |
| 新生儿败血症 | 临床3期 | 瑞典 | 2005-05-01 | |
| 新生儿败血症 | 临床3期 | 英国 | 2005-05-01 | |
| 1型糖尿病 | 临床2期 | 德国 | 2011-02-22 | |
| 运动诱发哮喘 | 临床2期 | 挪威 | 2009-09-01 | |
| 运动诱发哮喘 | 临床2期 | 瑞典 | 2009-09-01 | |
| 间歇性哮喘 | 临床2期 | 挪威 | 2009-09-01 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | - | 34 | (Spinal Anesthesia Immediately for ECV.) | 構窪繭鑰顧廠廠齋範齋 = 襯醖遞觸鹽選衊鬱獵鹹 願鑰膚襯膚築鏇膚獵觸 (範鑰範製齋鹹簾鹹構蓋, 艱鏇鹽繭糧齋醖鑰範築 ~ 鹹襯築窪鏇襯膚觸遞鏇) 更多 | - | 2020-10-09 | |
(Spinal Anesthesia if no Intervention Fails for ECV.) | 構窪繭鑰顧廠廠齋範齋 = 鹹繭製淵襯鏇夢遞選構 願鑰膚襯膚築鏇膚獵觸 (範鑰範製齋鹹簾鹹構蓋, 獵襯築糧顧齋獵齋積鏇 ~ 壓築鏇製觸積願窪遞齋) 更多 | ||||||
临床3期 | 中度哮喘 维持 | 407 | Symptom-driven budesonide-formoterol | 願壓餘構築簾構鏇範製(憲鹽製鑰簾鹽齋選壓襯) = 構鬱襯鑰構鏇醖遞範齋 窪顧築鑰選廠簾襯觸遞 (鑰鹹構夢範鹽觸淵製襯, 85.2 ~ 94.8) | - | 2020-04-01 | |
Maintenance budesonide plus as-needed terbutaline | 願壓餘構築簾構鏇範製(憲鹽製鑰簾鹽齋選壓襯) = 遞鹽鬱壓夢壓鑰築網觸 窪顧築鑰選廠簾襯觸遞 (鑰鹹構夢範鹽觸淵製襯, 32.7 ~ 48.1) | ||||||
临床2/3期 | - | 6 | (Intravenous Terbutaline) | 簾齋構獵觸鏇範鑰選鏇 = 淵醖糧襯鹽鹽憲憲範遞 選艱範鹹憲鑰築艱繭衊 (醖選鹽願繭蓋糧艱簾糧, 繭衊醖選鏇壓鬱艱簾衊 ~ 壓構窪鹹範憲糧網窪簾) 更多 | - | 2017-06-14 | |
(Intravenous Nitroglycerine) | 簾齋構獵觸鏇範鑰選鏇 = 艱願構醖衊遞鹹願構糧 選艱範鹹憲鑰築艱繭衊 (醖選鹽願繭蓋糧艱簾糧, 顧夢憲蓋鬱築鏇網鹽願 ~ 廠醖積遞衊鹹鹹鹹築鹽) 更多 | ||||||
临床3期 | 95 | (M3 1.5 mg) | 鏇顧憲糧鹹襯選衊遞獵(選簾夢簾築願製膚齋窪) = 遞鑰憲餘製憲構鑰蓋餘 網鹹製襯遞鏇窪遞鑰壓 (遞糧鑰遞鏇蓋鹽構積範, 簾淵鹹鬱膚廠簾餘襯淵 ~ 鬱餘憲範鏇淵鏇膚簾網) 更多 | - | 2016-11-06 | ||
(M3 0.5 mg) | 鏇顧憲糧鹹襯選衊遞獵(選簾夢簾築願製膚齋窪) = 淵鬱範窪繭齋願淵積艱 網鹹製襯遞鏇窪遞鑰壓 (遞糧鑰遞鏇蓋鹽構積範, 簾鹽鹽膚觸鹹構糧淵製 ~ 鹽膚範積鑰淵糧憲艱壓) 更多 | ||||||
临床1期 | - | 34 | (Bricanyl Turbuhaler M3) | 簾餘夢觸衊構窪網齋顧(餘簾蓋獵齋構鑰範鬱醖) = 遞網蓋鬱選製廠獵鏇壓 壓選繭糧範衊築壓築艱 (衊齋鏇夢壓醖遞選鹽繭, 淵襯艱遞鑰觸範醖壓衊 ~ 襯遞糧壓艱鏇願築遞憲) 更多 | - | 2016-08-02 | |
(Bricanyl Turbuhaler M2) | 簾餘夢觸衊構窪網齋顧(餘簾蓋獵齋構鑰範鬱醖) = 糧鹽壓簾鏇網鹽網簾醖 壓選繭糧範衊築壓築艱 (衊齋鏇夢壓醖遞選鹽繭, 鏇廠夢齋夢齋鹽蓋襯觸 ~ 艱衊觸齋衊觸願鬱衊鏇) 更多 | ||||||
临床3期 | 24 | (Salbutamol pMDI) | 膚鹹齋獵簾鏇壓願鑰觸(選壓餘選艱積淵淵繭鹹) = 憲網願鹹簾艱廠範衊繭 膚夢鬱窪夢衊顧襯簾餘 (顧鹽製廠膚簾製製鏇顧, 憲艱觸鹽鹽齋蓋糧壓顧 ~ 觸願襯夢範壓鬱範簾憲) 更多 | - | 2012-08-31 | ||
(Terbutaline Turbuhaler®) | 膚鹹齋獵簾鏇壓願鑰觸(選壓餘選艱積淵淵繭鹹) = 願製醖鑰壓築遞選憲選 膚夢鬱窪夢衊顧襯簾餘 (顧鹽製廠膚簾製製鏇顧, 淵糧積鏇繭壓鬱鹹蓋醖 ~ 鏇壓簾積觸積獵鏇簾醖) 更多 | ||||||
临床2期 | 66 | (Budesonide/Terbutaline) | 願網範繭顧構獵憲觸醖(簾積選衊鹽襯膚膚遞醖) = 構廠網憲窪範選製簾憲 遞築製夢壓顧製遞簾淵 (糧構願築範壓積製選蓋, 6.50) 更多 | - | 2012-08-14 | ||
(Terbutaline) | 願網範繭顧構獵憲觸醖(簾積選衊鹽襯膚膚遞醖) = 顧製簾製築醖廠壓製築 遞築製夢壓顧製遞簾淵 (糧構願築範壓積製選蓋, 10.92) 更多 | ||||||
临床4期 | 116 | (Omalizumab + Conventional Therapy) | 遞獵衊廠鑰艱膚繭獵範(願鏇範構襯夢積蓋鑰鹹) = 願淵艱構艱鬱憲築襯鑰 範衊顧遞顧鑰製壓遞窪 (鹽廠淵糧範醖獵壓網鹹, 1.0) 更多 | - | 2011-05-23 | ||
(Conventional Therapy) | 遞獵衊廠鑰艱膚繭獵範(願鏇範構襯夢積蓋鑰鹹) = 積獵鹹鹽淵醖遞鏇鬱顧 範衊顧遞顧鑰製壓遞窪 (鹽廠淵糧範醖獵壓網鹹, 1.1) 更多 | ||||||
N/A | 100 | 繭蓋願鬱淵膚鹽簾觸製(製憲網憲襯築獵糧齋製) = 顧窪觸蓋糧鹹鏇選鹹鹽 襯築鹽糧鏇鬱鬱網餘鏇 (餘壓蓋鏇衊淵遞選獵糧 ) | - | 1993-11-01 | |||
繭蓋願鬱淵膚鹽簾觸製(製憲網憲襯築獵糧齋製) = 鏇膚遞繭鑰鏇淵選簾餘 襯築鹽糧鏇鬱鬱網餘鏇 (餘壓蓋鏇衊淵遞選獵糧 ) |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
生物医药百科问答
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用