预约演示
更新于：2026-10-19
Paroxetine Hydrochloride
盐酸帕罗西汀
更新于：2026-10-19
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C19H21ClFNO3 |
InChIKeyGELRVIPPMNMYGS-RVXRQPKJSA-N |
CAS号78246-49-8 |
关联
294
项与 盐酸帕罗西汀 相关的临床试验NCT07715669
Role of Antidepressant Therapy to Improve Vascular Function After Preeclampsia
Preeclampsia is a condition in pregnancy where a woman develops high blood pressure and other complications. Women who develop preeclampsia are 4 times more likely to have heart disease later in life. They are also more likely to have depression after pregnancy. Why they are more likely to develop these conditions is not known. It may be because their blood vessels were damaged during pregnancy. Changes in blood vessel health can predict heart disease. These changes have been recorded after pregnancy in women who had preeclampsia. These changes have also been recorded in women who have depression. In the previous phase of this award, we found that women who had preeclampsia in pregnancy had changes in blood vessel health after pregnancy. We also found that if these women were taking a medicine to treat depression, their blood vessel health was normal. This could mean that treatment for depression can also increase blood vessel health in women who had preeclampsia. In this project we will study how changes in blood vessel health are related to preeclampsia and depression in women who have had both. We will also study how medicine to treat depression can improve blood vessel health after preeclampsia. We will do this by measuring how blood vessels work in women who have had preeclampsia compared to women who did not, and in women who have depression and women who do not. This will tell us more about why risk for depression and heart disease is higher in women who have had preeclampsia. It will also help us understand if medicine for depression can reduce cardiovascular disease risk after preeclampsia.
开始日期2026-08-30 |
申办/合作机构 |
CTIS2025-522967-13-00
A multicenter randomized, controlled, single-blind, adaptive phase IV clinical trial to evaluate the efficiency and effectiveness of a pre-emptive pharmacogenetic strategy for antidepressant selection in patients with depressive disorder: The PREDICT adaptive clinical trial.
开始日期2026-08-10 |
NCT07669571
A Phase I, Double-blind, Placebo-controlled Study to Evaluate Safety, Pharmacokinetics, and Pharmacodynamics of NS-079 in Healthy Participants
The goal of this clinical trial is evaluate the safety, pharmacokinetics, and pharmacodynamics of NS-079 with its main metabolite (NS-079-M1) in healthy participants. The main questions it aims to answer are:
* Is NS-079 safe and tolerable in heathy participants under tested dosing regimen?
* What is the pharmacokinectic profile of NS-079 in healthy participants under tested dosing regimen and the effect of paroxetine? Researchers will compare NS-079 to a placebo to see the safety and tolerability when use NS-079.
* Is NS-079 safe and tolerable in heathy participants under tested dosing regimen?
* What is the pharmacokinectic profile of NS-079 in healthy participants under tested dosing regimen and the effect of paroxetine? Researchers will compare NS-079 to a placebo to see the safety and tolerability when use NS-079.
开始日期2026-07-30 |
申办/合作机构 |
100 项与 盐酸帕罗西汀 相关的临床结果
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100 项与 盐酸帕罗西汀 相关的转化医学
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100 项与 盐酸帕罗西汀 相关的专利（医药）
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4,869
项与 盐酸帕罗西汀 相关的文献（医药）2025-11-01·ENVIRONMENTAL RESEARCH
Mechanisms of cellular and molecular responses in Mytilus galloprovincialis exposed to human pharmaceuticals ibuprofen, paroxetine and their mixture
Article
作者: Rovere, Giulia Dalla ; Di Carlo, Marta ; Benedetti, Maura ; Ferraresso, Serena ; Nardi, Alessandro ; Mezzelani, Marica ; Gorbi, Stefania ; Bernardini, Ilaria ; Milan, Massimo ; Regoli, Francesco ; Fattorini, Daniele ; El Idrissi, Ouafa ; d'Errico, Giuseppe ; Panni, Michela
The toxicological effects of pharmaceutical mixtures on marine ecosystems remain poorly understood, representing a significant research gap. This study investigated the interactions between ibuprofen (IBU) and paroxetine (PAR), two of the most consumed pharmaceuticals in Europe, by characterizing the molecular and cellular mechanisms behind their modes of action (MOAs) in non-target species. Mussels, Mytilus galloprovincialis were exposed to representative environmental concentrations (1 μg/L) of IBU and PAR, dosed alone and as a mixture, for 30 days, followed by a 14-days recovery period. A multidisciplinary approach was applied, combining measurements of drugs bioaccumulation, transcriptomic responses, a wide range of biochemical, cellular biomarkers, and microbiota analysis. The overall results suggested MOA of the two drugs in mussels similar to those reported for target species. PAR-driven effects were clearly observed, particularly in terms of perturbation of redox homeostasis and impairment of lipid metabolism. Remarkable competing effects were also highlighted including a lower uptake of IBU when in mixture with PAR, along with changes on biotransformation, metabolism, and excretion processes at transcriptional level. At the end of the depuration period, mussels showed an almost complete elimination of previously accumulated drugs which, however, did not reflect their capability to restore physiological homeostasis, both in terms of detrimental molecular, cellular effects and changes in bacterial communities. Overall, these findings suggest the need to consider complex environmental interactions when assessing the long-term impacts of pharmaceuticals in marine ecosystems.
2025-10-01·BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Harnessing integrated bioinformatics to identify new diagnostic and therapeutic strategies for heart failure
Article
作者: Wang, Ruilin ; Shang, Min ; Huang, Chengchen ; Fu, Guosheng ; Sun, Shuo ; Lai, Chaojie
Heart failure (HF) is a life-threatening condition that poses a significant challenge on public health, particularly among the elder populations. To develop new diagnostic and therapeutic strategies for HF, we analyzed large-scale transcriptome sequencing data from HF patients as an exploratory approach. We identified 18 HF-related genes and developed a robust scoring model for HF diagnosis, by applying two machine learning algorithms for data analysis. Meanwhile, we evaluated and compared the predictive abilities of three bioinformatics methods in identifying potential HF treatment drugs. Significantly, an unconventional network-based proximity analysis, integrating multidimensional drug target information, outperformed other methods in the assessment of predictive ability. To validate these findings, we tested several candidate drugs in a mouse model transitioning from acute myocardial infarction (MI) to chronic HF. Among the candidates, mirtazapine exhibited cardioprotective effects in both early (1-week) post-MI and chronic HF (4-week post-MI) settings, while cabergoline showed potential efficacy primarily in the early post-MI phase. Additionally, the screened triamterene, used as a positive control, exhibited protective effects in both early post-MI and chronic HF stages. Mechanistic studies revealed that growth factor receptor-bound protein 14 and Ras-related protein Rab-3A were critical to the observed cardioprotection. These findings provide valuable evidence and insights for exploring potential therapeutic agents for HF treatment.
2025-10-01·JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Immobilization of human myeloperoxidase on silica gel for inhibitors assessment
Article
作者: Kauffmann, Jean-Michel ; Delporte, Cédric ; Zouaoui Boudjeltia, Karim ; Van Antwerpen, Pierre ; Parsajoo, Yalda Cobra
Myeloperoxidase (MPO), a hemo-protein present in neutrophils and monocytes, significantly contributes to immune responses against microbial pathogens. Increased MPO activity, however, promotes the production of highly reactive oxidized species in extracellular fluids that can damage host tissues causing inflammatory events. To explore the potential of MPO as a target for inhibitor screening, this study aimed to develop and evaluate a mini-reactor system based on immobilized MPO. Several immobilization strategies including physical adsorption and covalent binding, were tested using silica gel as the support material. Among them, immobilization via cyanogen bromide (CNBr) activation was selected as the optimal method based on long-term stability (> 90 % after 20 runs) and a relative activity of 60 % after immobilization. Kinetic parameters for H2O2 were determined to characterize the enzymatic behavior post-immobilization, including Kmapp and Vmax (46 ± 4 µM and 463 ± 38 µM/min, respectively). The system was then employed to evaluate the inhibitory potency (IC₅₀) of three model compounds-salicylhydroxamic acid (SHA), paroxetine (PARO), and 4-aminobenzohydrazide (4-ABAH)-on HOCl production in the presence of 10 µM H₂O₂. 4-ABAH emerged as the most potent irreversible inhibitor (IC₅₀ = 0.30 µM), while SHA was the least effective (IC₅₀ = 27.10 µM). Those results demonstrated that immobilized-MPO preserved its activity and exhibited good stability. This mini-reactor provides a reliable platform for inhibitor studies, offering potential applications in screening therapeutic compounds to mitigate MPO-related inflammatory conditions.
329
项与 盐酸帕罗西汀 相关的新闻（医药）2026-10-18
·勤奋医考
各位备考执业药师的小伙伴，大家好。
《药学专业知识一》是很多考生备考路上的难点，知识点零散、化学结构多、概念易混淆，复习时很难抓住核心。
今天整理了药一300个高频考点精简笔记，把历年考试常考的基础概念、药物结构、代谢特点、药典规定、剂型辅料等内容汇总，剔除冷门偏题，方便大家碎片化复习。✅ 一、药品基础概念考点
药品的通用名也称国际非专利药品名称（INN），也是药典中推荐使用的名称，一个药物只有一个通用名，不受专利和行政保护。
药物的商品名通常针对最终产品，不得冒用顶替。商品名同商标一样可以注册和申请专利保护，只能由该药品的拥有者和制造者使用，不能暗示药物的疗效和用途，应简易顺口。
地西泮为中枢镇静药，结构母核为苯二氮䓬。
阿昔洛韦为抗病毒药，结构母核为鸟嘌呤。
氯丙嗪为抗精神病药，结构母核为吩噻嗪类。
剂型：是适合于疾病的诊断、治疗或预防的需要而制备的不同给药形式。
药物制剂：指将原料药物按照某种剂型制成一定规格并具有一定质量标准的具体品种。💊 给药剂型分类（非胃肠道给药）
注射给药：静脉、肌内、皮下及皮内注射；
皮肤给药：外用溶液剂、洗剂、软膏剂、贴剂、凝胶剂等；
口腔给药：漱口剂、含片、舌下片剂、膜剂；
鼻腔给药：滴鼻剂、喷雾剂、粉雾剂等；
肺部给药：气雾剂、吸入剂、粉雾剂等；
眼部给药：滴眼剂、眼膏剂、眼用凝胶、植入剂等；
直肠、阴道和尿道给药：灌洗剂、栓剂等。
8. 药物剂型的重要性：可改变药物的作用性质、可调节药物的作用速度、可降低（或消除）药物的不良反应、可产生靶向作用、可提高药物的稳定性、可影响疗效。
9. 硫酸镁：口服剂型用作泻下药，但5%注射液静脉滴注，具有镇静、解痉作用。
10. 药用辅料的作用：赋形、使制备过程顺利进行、提高药物稳定性、提高药物疗效、降低药物不良反应、调节药物作用、增加病人用药的顺应性。✅ 二、药物稳定性相关考点⚠️ 易发生水解的药物
酯类：盐酸普鲁卡因、盐酸丁卡因、硫酸阿托品、氢溴酸后马托品、溴丙胺太林、盐酸可卡因；
酰胺（含内酰胺）：对乙酰氨基酚、巴比妥类、利多卡因、青霉素类、头孢菌素类、氯霉素；
其他：阿糖胞苷；维生素B、地西泮、碘苷。⚠️ 易发生氧化的药物
酚类（含酚羟基）：如肾上腺素、左旋多巴、吗啡、水杨酸钠；
烯醇类（烯醇基）：维生素C；
其他类：噻嗪类（盐酸氯丙嗪、盐酸异丙嗪）、芳胺类（磺胺嘧啶钠）、吡唑酮类（氨基比林、安乃近）、维生素A或维生素D等。
14. 药物制剂稳定化方法：控制温度、调节pH、改变溶剂、控制水分及湿度、遮光、驱逐氧气、加入抗氧剂或金属离子络合剂、其他（改进剂型或生产工艺、制成稳定的衍生物、加入干燥剂及改善包装）。
15. 常用的水溶性抗氧剂：①亚硫酸钠、硫代硫酸钠：用于碱性药物溶液；②亚硫酸氢钠、焦亚硫酸钠：用于弱酸性溶液；③硫脲、维生素C、半胱氨酸等。
16. 常用的油溶性抗氧剂：叔丁基对羟基茴香醚（BHA），2，6-二叔丁基对甲酚（BHT）、维生素E。
17. 药品有效期：药物降解10%所需的时间，记作\boldsymbol{t_{0.9}}。公式：\boldsymbol{t_{0.9}=0.1054/k}。✅ 三、《中国药典》相关考点
18. 《中国药典》组成：
一部：药材和饮片、植物油脂和提取物、成方制剂和单味制剂；
二部：化学药品、抗生素和生化药品、放射性药品；
三部：生物制品；
四部：通则和药用辅料。
19. 凡例：是正确使用《中国药典》进行药品质量检定的基本原则，是《中国药典》的重要组成部分，对药典收载的正文与通则的有关规定具有法定的约束力。
20. 紫外-可见分光光度法：吸收波长λ，吸光度A。
21. 红外分光光度法：化合物的红外吸收光谱具有人指纹一样的特征专属性，几乎没有两个化合物具有相同的红外光谱。
22. 色谱鉴别法：用于鉴别的色谱法主要是高效液相色谱法（HPLC），以含量测定项下记录的色谱图中待测成分色谱峰的保留时间（tR）作为鉴别依据。📋 标准物质分类
23. 标准物质：系指供药品检验（鉴别、检查、含量或效价测定）中使用的，具有确定特性量值，用于校准设备、评价测量方法、给供试药品赋值或者鉴别用的物质。国家药品标准物质共有五类：标准品、对照品、对照药材、对照提取物、参考品。
24. 标准品：系指用于生物检定或效价测定的标准物质，其特性量值按效价单位（U）或重量单位（μg）计，以国际标准物质进行标定，供试品的效价以标准品的效价单位赋值。
25. 对照品：系指采用理化方法进行鉴别、检查或含量测量时使用的标准物质，其特性量值一般按纯度（%）计。📦 贮藏术语考点
26. 避光：系指避免日光直射；
27. 遮光：系指用不透光的容器包装；
28. 密闭：系指可防止尘土及异物进入的容器包装；
29. 密封：系指用可防止风化、吸潮、挥发或异物进入的容器包装；
30. 熔封或严封：系指可防止空气、水分的侵入与微生物污染的容器或适宜的材料包装；
31. 阴凉处：系指贮藏处温度不超过\boldsymbol{20℃}；
32. 凉暗处：系指贮藏处避光且温度不超过\boldsymbol{20℃}；
33. 冷处：系指贮藏处温度为\boldsymbol{2℃～10℃}；
34. 常温：系指温度为\boldsymbol{10℃～30℃}。✅ 四、生物药剂学与药物结构考点
35. 生物等效性研究方法按照研究方法评价效力，其优先顺序为药代动力学研究（评价指标Cmax和AUC）、药效动力学研究、临床研究和体外研究。
36. 血样包括：全血、血浆、血清（血浆：更可靠的指标；血清：制备方便，更常用）。
37. 羟甲戊二酰辅酶A还原酶抑制剂类降血脂药物的药效团：3，5-二羟基羧酸。🔗 药物与作用靶标的结合形式
38. 共价键：是一种不可逆的结合形式，多发生在化学治疗药物的作用机制上，如烷化剂类抗肿瘤药物，对DNA中鸟嘌呤碱基产生共价结合键，产生细胞毒活性。
39. 离子键（盐键）：去甲肾上腺素与β肾上腺素受体、拟胆碱药物氯贝胆碱与M胆碱受体相结合。
40. 氢键：酰胺类利尿药与碳酸酐酶结合、水杨酸甲酯形成分子内氢键，用于肌肉疼痛的治疗。
41. 离子-偶极和偶极-偶极相互作用：通常见于羰基类化合物，如镇痛药美沙酮与阿片受体结合产生镇痛作用。
42. 金属络合物可用作金属中毒时的解毒剂，二巯基丙醇作为锑、砷、汞的螯合解毒剂。
43. 药物与生物大分子的相互作用有时不单纯是一种结合模式，普鲁卡因的结合模式有：范德华力、偶极-偶极作用、静电引力、疏水性作用。🧪 BCS药物分类
44. 第Ⅰ类药物特点：高溶解度、高渗透性的两亲性分子药物，其体内吸收取决于溶出度，代表药物：普萘洛尔、马来酸依那普利、盐酸地尔硫䓬。
45. 第Ⅱ类药物特点：低溶解度、高渗透性的亲脂性分子药物，其体内吸收取决于溶解度，代表药物：双氯芬酸、卡马西平、吡罗昔康。
46. 第Ⅲ类药物特点：高溶解度、低渗透性的水溶性分子药物，其体内吸收取决于药物渗透率，代表药物：雷尼替丁、纳多洛尔、阿替洛尔。
47. 第Ⅳ类药物特点：低溶解度、低渗透性的疏水性分子药物，体内吸收比较困难，代表药物：特非那定、酮洛芬、呋塞米。
48. 酸性药物：\boldsymbol{pK_a=pH+log[HA]/[A^-]} ；碱性药物：\boldsymbol{pK_a=pH+log[HB^+]/[B]}。🧬 官能团对药效的影响
49. 烃基：脂溶性↑、脂水分配系数（logP）↑，位阻↑，稳定性↑。环己巴比妥引入甲基→海索比妥，不易解离。
50. 卤素：有较强的电负性，会产生电性诱导效应，脂溶性↑，改变电子分布。安定作用：氟奋乃静＞奋乃静；抗炎作用：醋酸氟氢化可的松＞醋酸氢化可的松。
51. 羟基：增强与受体结合力，水溶性↑，改变活性。
52. 胺类：①活性：伯胺＞仲胺＞叔胺；②季铵：作用强，水溶性大，不易透过生物膜和血脑屏障，无中枢作用。🌀 对映异构体药效特点
53. 对映异构体之间具有等同的药理活性和强度：普罗帕酮、氟卡尼。
54. 对映异构体之间产生相同的药理活性，但强弱不同：氧氟沙星、氯苯那敏、萘普生。
55. 对映异构体中一个有活性，一个没有活性：L-甲基多巴、氨己烯酸。
56. 对映异构体之间产生相反的活性：哌西那朵、扎考必利、依托唑啉、异丙肾上腺素。
57. 对映异构体之间产生不同类型的药理活性：右丙氧芬—左丙氧芬、麻黄碱—伪麻黄碱、奎宁—奎尼丁。
58. 一种对映体具有药理活性，另一对映体具有毒性作用：氯胺酮、乙胺丁醇、青霉胺、四咪唑、米安色林、左旋多巴。✅ 五、药物代谢、各类药物考点🔄 药物代谢反应
59. 含芳环的药物——氧化代谢：普萘洛尔→羟基普萘洛尔；丙磺舒→无苯环氧化代谢产物；氯丙嗪；保泰松→羟布宗；苯妥英→羟基苯妥英；S-（-）-华法林→7-羟基华法林。
60. 烯烃：环氧化合物→二羟基化合物；例：卡马西平（环氧化物有抗惊厥活性）；己烯雌酚（己烯雌酚环氧化物）。
61. 含饱和碳原子的药物——氧化：地西泮（羰基的α-碳原子羟基化→替马西泮，经N-脱甲基和α-碳原子羟基化→奥沙西泮）。
62. N-氧化反应（叔胺、含氮芳杂环），如吗啡、胍乙啶、氨苯砜。
63. 醚类药物——O-脱烷基化反应。→醇或酚，以及羰基化合物。大部分是芳香醚。例：可待因、吲哚美辛。
64. 亚砜类的代谢：①氧化→砜；②还原→硫醚。例：舒林酸（前药）。
65. 含硝基的药物：芳香族硝基还原→芳香胺，例：氯霉素。
66. 葡萄糖醛酸的结合反应有：O、N、S和C的葡萄糖醛苷化和O、N、S的葡萄糖醛酸酯化、酰胺化。
67. 与谷胱甘肽的结合反应——白消安。
68. 乙酰化结合反应--对氨基水杨酸。
69. 甲基化结合反应--肾上腺素。
70. 抗过敏药物特非那定、阿司咪唑因干扰心肌细胞K⁺通道，引发致死性尖端扭转型室性心动过速，被美国FDA从市场撤回。
71. 奥沙西泮为地西泮的代谢产物，毒性低、副作用小，对焦虑、紧张及失眠均有效。
72. 三唑仑中三氮唑分子中的甲基提高了脂溶性，使其起效快，但甲基易被代谢成羟甲基失活，而成为短效镇静催眠药。
73. 佐匹克隆属于吡咯烷酮类药物，且其主要镇静催眠作用来自其右旋体。
74. 吩噻嗪类药物副作用：①光毒化变态反应（红疹，减少户外活动，避免日光照射）；②锥体外系反应。
75. 帕利哌酮是利培酮的活性代谢物，药用外消旋体。
76. 常用的去甲肾上腺素再摄取抑制剂：丙米嗪、氯米帕明、地昔帕明、阿米替林、多塞平。
77. 常用的选择性5-羟色胺再摄取抑制药有：西酞普兰、氟伏沙明、氟西汀、舍曲林、盐酸帕罗西汀。
78. 常用的单胺氧化酶抑制药有：吗氯贝胺、托洛沙酮。
79. 常用的5-羟色胺与去甲肾上腺素再摄取抑制剂：度洛西汀、文拉法辛、米氮平。
80. 吗氯贝胺与苯甲酰胺舒必利和甲氧氯普胺结构相似，对MAO-A有可逆性抑制作用，从而提高脑内去甲肾上腺素、多巴胺和5-羟色胺的水平，产生抗抑郁作用。
81. 瑞芬太尼分子中存在羧酸酯结构，具有起效快、维持时间短的特点，临床用于诱导和维持全身麻醉期间止痛、插管和手术切口止痛。
82. 烯丙吗啡和纳洛酮临床上可用于服用吗啡或海洛因中毒的成瘾者的解救。
83. 苯海拉明为氨基烷基醚类代表药，能竞争性阻断组胺H₁受体而产生抗组胺作用。
84. 茶苯海明克服了苯海拉明的嗜睡和中枢抑制副作用，临床用于防治晕动症。
85. 氯雷他定强效、长效、选择性对抗外周H1受体的非镇静类H1受体阻断药，地氯雷他定是氯雷他定的活性代谢物，为第三代受体阻断药。
86. 氯苯那敏含有一个手性碳原子，H1受体抗体均为S-（+）-体，临床用外消旋体的马来酸盐。
87. 甲基多巴为前体药物，临床实用外消旋体，用于治疗高血压、适用于肾性高血压和妊娠高血压。
88. 肾上腺素受儿茶酚-O-甲基转移酶（COMT）和单胺氧化酶（MAO）的催化。
89. 贝诺酯是阿司匹林分子中的羧基与对乙酰氨基酚的酚羟基成酯后的药物。
90. 对乙酰氨基酚其主要代谢物是与葡萄糖醛酸或硫酸结合产物，少部分可由CYP450氧化酶系统转化成毒性代谢产物N-羟基衍生物和N-乙酰亚胺醌；乙酰亚胺醌可耗竭肝内储存的谷胱甘肽，引起肝坏死；各种含巯基的药物可用作对乙酰氨基酚过量的解毒剂。对乙酰氨基酚不具有抗炎作用。
（后面剩余200+考点完整收录在资料中，篇幅原因，推文只展示部分核心考点）
91. 舒林酸前体药物，它在体外无效，在体内经肝代谢，甲基亚砜基被还原为甲硫基化合物而显示生物活性。
92. 塞来昔布胃肠道副作用小，但在临床使用中具有潜在心血管事件风险。
93. H2受体阻断药：西咪替丁结构：咪唑+含硫醚四原子链+末端取代胍；盐酸雷尼替丁为反式体，顺式体无活性。
94. 质子泵抑制药：奥美拉唑—前药循环；清除率：R-异构体＞S-异构体；R-异构体经CYP2C19酶催化代谢，S-异构体经CYP3A4途径代谢。
95. 艾司奥美拉唑是第一个上市的光学活性质子泵抑制药。
96. 甲氧氯普胺分子中含苯甲酰胺结构，有锥体外系副作用，常见嗜睡和倦怠。
97. 伊托必利具有阻断多巴胺D2受体活性和抑制乙酰胆碱酯酶活性的双重活性；通过对D2受体的拮抗作用而增加乙酰胆碱的释放，同时通过对乙酰胆碱酯酶的抑制作用来抑制已释放的乙酰胆碱分解，增强胃、十二指肠收缩力，加速胃排空，并有止吐作用。中枢神经系统分布少，选择性高，不良反应少。不产生甲氧氯普胺的锥体外系症状，无西沙必利的致室性心律失常及其他严重的药物不良反应。
98. 血管紧张素转换酶抑制药：依那普利是双羧基ACE抑制剂药物的代表，分子中含三个手性中心，均为S构型，代谢为依那普利拉（只能静注，而依那普利口服好）。
99. 卡托普利是含巯基的ACE抑制剂的唯一代表；巯基和脯氨酸片段：关键药效团；斑丘疹和味觉障碍的高发生率与卡托普利的巯基（-SH）有关。
100. 赖诺普利和卡托普利也是当前唯一使用的两个非前药的ACE抑制剂。
101. 缬沙坦：用于各类轻、中度高血压，尤其对ACE抑制剂不耐受的患者；缬沙坦+氨氯地平，治疗原发性高血压，特别是单药治疗不能充分控制血压的患者；缬沙坦+氢氯噻嗪，治疗单一药物不能充分控制血压的轻度至中度原发性高血压。
102. 羟甲戊二酰辅酶A还原酶抑制药中属于前药的有：洛伐他汀、辛伐他汀；非前药的有：普伐他汀、氟伐他汀、阿托伐他汀、瑞舒伐他汀。
103. 洛伐他汀为天然HMG-CoA还原酶抑制剂，内酯结构（前药），体外无HMG-CoA还原酶抑制作用，水解为3，5-二羟基戊酸才表现出活性，能显著降低LDL水平，并能提高血浆中HDL水平，用于治疗高胆固醇血症和混合型高脂血症，也可用于缺血性脑卒中的防治。
104. 硝苯地平为对称结构的二氢吡啶类药物，无手性碳，用于治疗冠心病，缓解心绞痛，适用于各种类型的高血压。
105. 尼群地平4位碳原子具手性，临床用外消旋体，为选择性作用于血管平滑肌的钙通道阻滞剂，降压作用温和而持久。
106. 氨氯地平2位甲基被2-氨基乙氧基甲基取代，3、5位羧酸酯的结构不同，1个手性碳，临床用外消旋体和左旋体。
107. 尼莫地平容易通过血脑屏障，临床用于预防和治疗蛛网膜下出血后脑血管痉挛所致的缺血性神经障碍、高血压和偏头痛等。
108. 维拉帕米含有手性碳，右旋体作用强，现用外消旋体，化学稳定性好，呈弱酸性，但甲醇溶液紫外线2h可分解50%。代谢：N-脱甲基（去甲维拉帕米）。
109. 地尔硫䓬：有2个手性碳原子，具有四个立体异构体，临床仅用其d-顺式异构体，即（2S，3S）-异构体，较高的首过效应，主要代谢途径为脱乙酰基、N-脱甲基和O-脱甲基化。
110. 华法林钠含有一个手性碳，S-异构体的抗凝活性是R-异构体的4倍，药用其外消旋体，主要经肝脏CYP450酶代谢，故甲硝唑、氯霉素、西咪替丁、奥美拉唑和选择性5-羟色胺再摄取抑制药，可使本品的代谢减慢，半衰期延长，抗凝作用加强。
111. 氯吡格雷一个手性碳原子，为S-构型，体外无活性，前药，临床用于预防缺血性脑卒中、心肌梗死及外周血管病等。
112. 肾上腺糖皮质激素的基本结构是含有\triangle^4-3，20-二酮和11，17α，21-三羟基孕甾烷。📝 备考小结
药一学习切忌死记硬背，优先抓住基础概念、药典贮藏、药物官能团、对映异构体、药物代谢这几大高频板块。
这份300考点笔记，适合一轮复习打底、二轮刷题复盘、考前快速过一遍核心考点。
2026-10-13
人物：马大为
有一种科学家，名字不在药盒上，却藏在你的药片里。中国科学院院士、南方科技大学化学系讲席教授马大为就是这样一个人。他高考时一心想学数学，却被分进了化学系；三十五岁那年一次"顺手"的实验意外，让他找到了一把钥匙，把一个尘封近百年的老化学反应从"高温猛火"里解放出来。今天，全世界做新药研发的实验室几乎每天都在用这个方法。年过花甲，他还在找第三代催化剂——因为让药再便宜一点点，是这一代中国化学家该干的事。
作者/柏舟 图片/网络
一个"顺手"的发现，惊动了整个制药业
他只想合成一种抑制剂，却给一个百岁老反应装上了加速器。1998年夏天，上海。中科院上海有机化学研究所的实验室里，马大为在重复一个做过无数遍的实验。目标并不宏大：合成一种蛋白激酶抑制剂。结果，试管里出了意外。他发现一类氨基酸分子，可以大幅提高一个老牌反应的效率。这个反应叫乌尔曼反应，1901年由德国化学家乌尔曼发现，用途是把简单分子片段"焊接"成复杂分子——制药工业天天要干的活。但它的脾气极坏：需要大量铜作催化剂，还得加热到一百五十到二百五十摄氏度。这么高的温度，很多结构精巧的药物分子骨架会被直接"烤坏"。近百年来，它好用，却不敢随便用。马大为发现的那类氨基酸分子，相当于给铜找了个搭档（化学上叫配体）。有了它，温度降下来了，铜的用量也大幅减少。一个苛刻的老反应，从此变得温和、听话、普适。那一年，他三十五岁。用他自己的话说，这是"无心插柳"。但业内知道，这片柳荫有多大。
一条"错配"出来的化学之路
高考数学丢了二十分，他报的是数学系，却被分去了化学系。1963年9月，马大为出生在河南南阳社旗县一个教师家庭。少年时赶上"科学的春天"，看了哥德巴赫猜想的报道后，他把陈景润、张广厚当成偶像，心思全扑在数学上，化学上花的时间连数学的十分之一都不到。然后高考出事了。"我一出考场就想起来了，移项时符号没有变。"一道题丢掉二十分，数学只考了七十七分，化学反倒九十多分。他报的是山东大学数学系，被分到了化学系。入学头半年，他一直想"混到数学系"，还跑去数学系转了几圈。没有转专业的机会，只能硬着头皮读，"说实在的，还是很郁闷"。改变他的是科学史——读到居里夫人从成吨沥青里一点点提取出镭，他忽然觉得化学也不错；大二有机化学里那些不可预测的繁复变化，更让他觉得有趣又有挑战。后来他反复跟学生讲：一定要培养兴趣，看别人的文章时，要能像音乐家听音乐那样，从中得到兴奋感。1984年毕业后，他考入中科院上海有机化学研究所，是山大第一个考上该所的学生，师从陆熙炎教授，五年硕博连读。毕业时他觉得自己在金属有机领域"已经基本到了顶峰"，于是做了一个大胆决定：转向当时国内尚属空白的交叉方向——有机化学与生命科学结合的药物合成。1990年赴美，在匹兹堡大学化学系和梅奥医学中心做四年博士后。1994年，尽管当时年薪已有三万美元，他仍选择回国，入选首批中科院"百人计划"。那时的有机所做药物合成的人才青黄不接，连间像样的实验室都没有，他就从找经费、搭实验室起步。1995年任研究员，1997年获国家杰出青年科学基金。2019年11月当选中国科学院院士（化学部）。2021年3月南下深圳，任南方科技大学化学系讲席教授。
让老反应变温和，让贵药变便宜，让难分子变可得
第一代配体偶然得之，第二代配体熬了十年，第三代他还在找。
把乌尔曼反应从"高温猛火"里救出来：氨基酸配体是第一代。之后他又用了整整十年，前后四五批学生接力，才找到效率更高的第二代配体草酰二胺，连活性很低的芳基氯代物都能催化。短短几年，工业应用就达到上吨级——荷兰皇家帝斯曼集团的抗高血压药培哚普利、英国一家药企的干眼病治疗药物，工业化生产都受益于它。江西萍乡一位七旬老人服用培哚普利控制血压，十年间药价从每盒三十五元降到十五元；降价原因很多，制药工艺升级是其中重要的一条。
把"最难合成的抗癌药"拉下神坛： 曲贝替定结构极其复杂，被称为世界上最难合成的两个抗癌药物分子之一，技术长期垄断在少数原研药企手里，国外一盒售价两三万元。马大为团队为它找到迄今最简便的路线：原先全合成要四十多个步骤，新路线只需二十六步。这条路线已进入工业化生产。
让候选药物从实验室走向临床： 他研发出治疗神经退行性疾病的细胞坏死抑制剂、治疗肺癌的新型表皮生长因子受体抑制剂，两个候选药物分别在欧洲和中国进入一期临床。此外还发展了抗抑郁药帕罗西汀、抗流感药达菲等的高效合成路线，完成六十余个复杂天然产物全合成，发表论文三百余篇。
六十岁之后仍在往前推： 2026年，团队在《美国化学会志》《德国应用化学》先后发表铜催化配体新方法，能构建难度极高的全碳季碳手性中心，并把催化转化数推到接近一万——目前该领域已报道的最高值，意味着催化剂用量可以压到极低。
"要改写化学教科书的反应"
同行两句话：一句"每天都要用"，一句"已经上吨级"。他发展的铜催化偶联反应，被国际同行评价为"现代药物发现最常用的方法之一"，是合成实验室里"每天都要用的反应"。美国斯克里普斯研究所教授余金权说得更直接：这个反应已在工业上产生上吨级应用，具有广谱性，"是要改写化学教科书的"。2018年11月，马大为与四川大学教授冯小明、南开大学教授周其林共获第三届未来科学大奖"物质科学奖"，理由是三人在发明新催化剂和新反应方面的创造性贡献，"为合成有机分子，特别是药物分子提供了新途径"。同年他获美国化学会阿瑟·科普学者奖，此前获国家自然科学二等奖、中国青年科技奖，此后获中国科学院杰出科技成就奖。更值得咀嚼的是成果的性质。中国化学论文的数量与被引次数早已位居世界前列，但能够改进社会生活的化学分子数以万计，无论发现过程还是制造过程，能打上中国人烙印的例子并不多。马大为的工作恰恰属于后者——它不只是一篇论文，而是一套被产业界真金白银采用的制造方法。
每天十二小时，与九成五的失败共处
他说科研九成五的时间是失败的，但失败是个好机会。在匹兹堡所在的美国东部，做有机合成这一行有个传统：每天干十二小时、每周六天甚至七天，是很多实验室的硬规定。马大为把它带了回来。理由很朴素："人家已经那么先进了，还这么努力地干活，你要想赶超人家，连这个都赶不上肯定不行。"如今年过花甲，只要不出差，他几乎每天仍花十到十二小时看资料、做研究；出差晚上九、十点回上海，也要去办公室转一趟才踏实。面对称赞，他很淡："没做什么，我就是个普通的科研人员。"但对科研风气的批评，他毫不含糊：科研不应扎堆凑热闹，也不要"做了几篇文章帮人家抬轿子，自己也没得到什么就换个热点走了"，而要做成自己的特色、做到一定的深度。他直言国内存在"内卷"，根源是部分单位不按科研规律设岗招人，破局要靠分类改革——基础研究交给精英，应用研究交给市场。至于"生化环材是四大天坑"的说法，他认为纯属误解：他所在的有机合成专业已经"招人都招不到"。关于失败，他的态度最见性情："做科研，可以说九成五以上的时间是失败的。但失败是一个好机会，能让人了解失败的原因。我们要鼓励大家去探索无人区。"
六十岁，他还在找第三代配体
他的梦想，是让第三代催化剂实现三位数的工业化应用。第一代配体，已经有了两三个工业化应用；第二代，有希望上两位数；第三代，他希望能冲到三位数。"也不能保证一定能发现，但它的意义非常重大。"从社旗县城走出来的少年，原本想成为数学家。他最终没有成为数学家，却做了一件同样漂亮的事：让一门近百岁的老化学变得温顺、便宜、好用，让全世界做药的人每天都在受益，也让普通人手里的药片有了降价的空间。有人问，中国创新药何时能从"中国制造"变成"中国创造"。他说，我国化学水平已接近世界顶尖，创新药研发浪潮的到来只是时间问题。而他自己，就是推着这个时间往前走的人之一。
拓展阅读及资料来源
1.《努力寻找药物合成的最优解（弘扬科学家精神）》，人民日报
2.《马大为院士：让药价更亲民》，健康时报，2025年6月20日
3.中国科学院学部院士简介
4.南方科技大学理学院专访
5.对科研评价体系与"短平快"研究的批评：南方科技大学新闻网
6.人民日报客户端《祝贺！南阳人马大为当选中国科学院院士》
7.中山大学药学院（深圳）相山讲坛主讲介绍
8.《学界星光·硕果盈枝｜乐研合作学者2月科研成果速递》，分析测试百科网
9.人物经历与研究综述综合参考：百度百科"马大为"词条
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2026-10-10
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截至10月10日15点59分，近期共有 541 本期刊发布了 1047 篇文章，其中糖尿病相关的文章共 301 篇，覆盖 33 个领域的内容。中国专家参与发表的文章有 100 篇。今日，影响因子最高的文章刊登在 Journal of the American Medical Association (IF: 55.000) 期刊上。
今日头条
Headlines
01 Frontiers in endocrinology IF: 04.600 糖尿病患者的社会网络特征、自我管理行为及自我效能的中介作用：一项多中心横断面研究
Xixuan Cai, JianJiang Pan, Gang Li, Tao Chen, Zhou Fang, Zhangqing Ren, etc.
一项多中心横断面研究探讨了中国糖尿病患者社会网络特征与自我管理行为的关系，并评估了自我效能的中介作用。
研究纳入2358例糖尿病患者，评估内容包括社会网络特征、自我效能及自我管理行为。
结果显示，参与者的平均糖尿病管理得分为36.51。回归模型表明，家庭网络规模（β=0.251, 95% CI: 0.048-0.455, P=0.016）和朋友网络规模（β=0.325, 95% CI: 0.147-0.504, P<0.001）均与更好的自我管理行为显著相关。家庭支持（β=0.558, 95% CI: 0.406-0.710, P<0.001）和朋友支持（β=0.624, 95% CI: 0.484-0.764, P<0.001）也显示出对自我管理行为的强烈正向效应。Pearson相关分析显示，社会网络特征、自我效能与自我管理行为之间存在显著正相关（p<0.001）。自我效能的中介作用得到证实，家庭支持和朋友支持的间接效应均显著。
亚组分析发现，女性朋友网络规模对自我管理行为有显著影响，男性家庭网络规模在调整后也有显著影响。家庭和朋友网络支持对男性和女性患者的自我管理行为均有显著正向影响。在60岁及以上和60岁以下人群中，朋友网络规模、家庭网络支持和朋友网络支持均与自我管理行为显著正相关。
研究结论强调，社会网络特征，特别是社会支持，对糖尿病患者的自我管理行为有显著影响。家庭和朋友支持正向影响自我管理行为，且自我效能介导这些关系。研究呼吁干预措施应考虑社会支持的性别特异性影响，并旨在提升自我效能以改善糖尿病患者的自我管理行为。
本文由 韩玉莲 编辑
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Frontiers in endocrinology | Volume 17, Issue
10.3389/fendo.2026.1934060
02 Frontiers in pharmacology IF: 04.800 SGLT2抑制剂、司美格鲁肽与非奈利酮治疗糖尿病肾脏病：一项贝叶斯网络荟萃分析
Zongze He, Xu Wang, Li Zhang, Xiangmei Chen, etc.
糖尿病肾病（DKD）仍是全球终末期肾病的首要病因。尽管肾素-血管紧张素系统（RAS）阻断是数十年来唯一循证药物策略，患者仍面临显著残余心肾风险。2024年FLOW试验确立了司美格鲁肽作为首个具有专门主要肾脏终点获益的胰高血糖素样肽-1（GLP-1）受体激动剂。
本研究开展贝叶斯网络荟萃分析，比较SGLT2抑制剂、司美格鲁肽与非奈利酮这三种具有当代3期心肾证据的疗法，以明确其在2型糖尿病合并慢性肾脏病中的比较有效性及安全性层级。
研究系统检索PubMed、Embase和Cochrane图书馆至2025年7月31日，纳入报告肾脏、心血管或安全性结局的3期随机试验。共纳入6个试验级数据集（CREDENCE、DAPA-CKD 2型糖尿病亚组、EMPA-KIDNEY 2型糖尿病亚组、FIDELIO-DKD、FIGARO-DKD、FLOW；N=20,521）。所有试验偏倚风险低。肾脏结局方面，SGLT2抑制剂显示最大风险降低（HR 0.70，95% CI 0.64-0.76；SUCRA 94.5%），其次为司美格鲁肽（HR 0.76，95% CI 0.66-0.88；SUCRA 68.0%）和非奈利酮（HR 0.84，95% rI 0.77-0.92；SUCRA 37.5%）。SGLT2抑制剂与非奈利酮的间接比较达到统计学显著性（HR 0.83，95% CI 0.73-0.95）。与既往通过网络荟萃分析合并非奈利酮试验不同，本研究将FIDELIO-DKD与FIGARO-DKD分离，得出非奈利酮合并HR为0.84，使该间接比较得以检出。此发现对分析决策敏感，应视为假设生成性。司美格鲁肽在数值上优于非奈利酮但未达统计学显著性（HR 0.90，95% CI 0.76-1.07）。
心血管结局方面，三种活性药物均显著降低心血管风险，活性药物间无统计学显著差异。所有关键发现在四项敏感性分析中保持稳定。
结论认为，SGLT2抑制剂在本网络中提供最大肾脏保护；当两项非奈利酮试验分别分析时，出现间接统计学显著的SGLT2抑制剂优势。司美格鲁肽提供显著肾脏保护，数值上优于非奈利酮。这些发现支持四支柱框架——RAS阻断与SGLT2抑制为基础组合，司美格鲁肽与非奈利酮为互补的表型匹配添加——并为个体化处方提供概率证据基础。
本文由 韩玉莲 编辑
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Frontiers in pharmacology | Volume 17, Issue
10.3389/fphar.2026.1882227
03 Frontiers in pharmacology IF: 04.800 替尔泊肽与其他抗糖尿病药物在2型糖尿病患者中预防糖尿病足并发症的比较
Chia-Yu Kuo, Jheng-Yan Wu, Ya-Wen Tsai, Chih-Cheng Lai, Jiun-Ling Wang, etc.
糖尿病足并发症影响高达25%的2型糖尿病患者，是致残和致死的重要原因。替尔泊肽作为一种双重葡萄糖依赖性促胰岛素多肽（GIP）和胰高血糖素样肽-1（GLP-1）受体激动剂，在血糖控制方面优于司美格鲁肽，但其对糖尿病足并发症的影响尚不明确。
本研究利用TriNetX全球联邦健康研究网络开展回顾性队列研究，纳入2022年1月至2025年7月期间新使用替尔泊肽、磺脲类、二肽基肽酶-4抑制剂（DPP-4）抑制剂、钠-葡萄糖协同转运蛋白2抑制剂（SGLT2）抑制剂或GLP-1受体激动剂的成人2型糖尿病患者。通过倾向性评分匹配创建四组平衡队列进行头对头比较。主要终点为糖尿病足并发症复合终点，包括溃疡、感染、严重肢体缺血以及血运重建或截肢。
匹配后，替尔泊肽 vs 磺脲类每组141,002例，替尔泊肽 vs DPP-4抑制剂每组131,449例，替尔泊肽 vs SGLT2抑制剂每组146,321例，替尔泊肽 vs GLP-1受体激动剂每组97,457例。与磺脲类相比，替尔泊肽与糖尿病足并发症风险降低相关（HR 0.80；95% CI 0.76-0.84）。与DPP-4抑制剂（HR 0.83；95% CI 0.78-0.87）和SGLT2抑制剂（HR 0.88；95% CI 0.83-0.92）相比也观察到类似降低。与GLP-1受体激动剂相比未发现差异（HR 0.97；95% CI 0.91-1.03）。
结论认为，与磺脲类、DPP-4抑制剂和SGLT2抑制剂相比，替尔泊肽与糖尿病足并发症减少相关，与GLP-1受体激动剂结局相似。这些发现提示替尔泊肽可能是溃疡或截肢风险患者的有价值选择。
本文由 韩玉莲 编辑
扫描二维码查看源文
Frontiers in pharmacology | Volume 17, Issue
10.3389/fphar.2026.1880132
中国发表（100）
China
Poultry science IF: 04.200Ahead of Print.No.01Integrative transcriptomic analysis reveals tissue associated molecular responses to heat stress in chickens整合转录组分析揭示鸡热应激的组织相关分子响应DOI: 10.1016/j.psj.2026.107884
Integrative biology : IF: 01.400Volume 18, Issue No.02Association between inflammatory burden index and cardiovascular and all-cause mortality in individuals living with diabetes and prediabetes: a NHANES cohort study炎症负担指数与糖尿病及糖尿病前期患者心血管死亡和全因死亡之间的关联：一项NHANES队列研究DOI: 10.1093/intbio/zyag019
JCMR IF: 06.100Ahead of Print.No.03Cardiovascular magnetic resonance derived myocardial strain: applications, acquisition techniques, analysis, and reporting. A Scientific Statement of the Society for Cardiovascular Magnetic Resonance, Radiological Society of North America, and the European Association of Cardiovascular Imaging of the ESC心血管磁共振衍生心肌应变：应用、采集技术、分析与报告。SCMR、RSNA与EACVI联合科学声明DOI: 10.1016/j.jocmr.2026.102758
Experimental neurology IF: 04.200Ahead of Print.No.04AgomiR-31-5p ameliorates diabetes-associated cognitive impairment by suppressing hippocampal neuroinflammation via RAGE-associated signalingAgomiR-31-5p通过抑制RAGE相关信号通路减轻海马神经炎症改善糖尿病相关认知障碍DOI: 10.1016/j.expneurol.2026.116050
Diabetes Res Clin Pract IF: 07.400Ahead of Print.No.05A nomogram for preoperative risk evaluation of Bethesda III thyroid nodulesBethesda III类甲状腺结节术前风险评估的列线图DOI: 10.1016/j.diabres.2026.113587
Journal of Advanced Research IF: 13.000Ahead of Print.No.06Aebp1 drives a ceramide-gated Calhm2 calcium influx that injures podocytes in diabetic kidney diseaseAebp1驱动神经酰胺门控的Calhm2钙内流损伤糖尿病肾病中的足细胞DOI: 10.1016/j.jare.2026.10.017
Ecotoxicol Environ Saf IF: 06.100Ahead of Print.No.07Sodium arsenite accelerates aging of Caenorhabditis elegans parents and offspring through the insulin signaling pathway, oxidative stress, and autophagy亚砷酸钠通过胰岛素信号通路、氧化应激和自噬加速秀丽隐杆线虫亲代和子代的衰老DOI: 10.1016/j.ecoenv.2026.120897
European journal of pharmacology IF: 04.700Ahead of Print.No.08Polydatin alleviates vascular calcification via the TP53/PI3K/AKT axis虎杖苷通过TP53/PI3K/AKT轴减轻血管钙化DOI: 10.1016/j.ejphar.2026.179419
Academic radiology IF: 03.900Ahead of Print.No.09Multimodal Carotid Ultrasound-based Artificial Intelligence Model for Predicting Acute Ischemic Stroke Risk in Patients with Type 2 Diabetes Mellitus基于多模态颈动脉超声的人工智能模型预测2型糖尿病患者急性缺血性卒中风险DOI: 10.1016/j.acra.2026.09.036
Toxicol Appl Pharmacol IF: 03.400Ahead of Print.No.10ATF3 inhibits retinal pigment epithelial cell injury by activating HSPA5:A mechanistic insight for diabetic retinopathyATF3通过激活HSPA5抑制视网膜色素上皮细胞损伤：糖尿病视网膜病变的机制见解DOI: 10.1016/j.taap.2026.118077
Phytomedicine IF: 08.300Ahead of Print.No.11Cinnamaldehyde protects against early diabetic retinopathy: an integrative In vivo and computational study肉桂醛对早期糖尿病视网膜病变的保护作用：一项整合体内与计算研究DOI: 10.1016/j.phymed.2026.158851
Acta biomaterialia IF: 09.600Ahead of Print.No.12Metformin-loaded multi-enzymatic metal-organic framework nanozyme mediates metabolic reprogramming via multiple energy blockades to boost tumor immunotherapy载二甲双胍多酶金属有机框架纳米酶通过多重能量阻断介导代谢重编程以增强肿瘤免疫治疗DOI: 10.1016/j.actbio.2026.10.014
Schizophrenia research IF: 03.500Volume 297, Issue No.13Anterior cingulate GABA and functional connectivity associated with initial treatment response in first-episode schizophrenia前扣带回GABA与功能连接与首发精神分裂症初始治疗反应的相关性DOI: 10.1016/j.schres.2026.09.014
IF: 03.700Ahead of Print.No.14DLL1 promotes diabetic cataract progression by driving epithelial-mesenchymal transition (EMT) via activation of the Notch signaling pathwayDLL1通过激活Notch信号通路驱动上皮-间质转化促进糖尿病性白内障进展DOI: 10.1016/j.bbamcr.2026.120233
Ultrasound in medicine & biology IF: 02.600Ahead of Print.No.15An Explainable Machine Learning Model Integrating Clinical Parameters for Identifying Left Atrial Appendage Thrombus in Non-valvular Atrial Fibrillation整合临床参数的可解释机器学习模型用于识别非瓣膜性心房颤动中的左心耳血栓DOI: 10.1016/j.ultrasmedbio.2026.09.012
Cancer control : IF: 02.600Volume 33, Issue No.16Association Between Multidisciplinary Team Meetings and Short-Term Postoperative Outcomes in Gastrointestinal Malignancies: A Retrospective Cohort Study多学科团队会议与胃肠道恶性肿瘤短期术后结局的关联：一项回顾性队列研究DOI: 10.1177/10732748261495563
Trends Endocrinol Metab IF: 12.600Ahead of Print.No.17The AdipoCode: an information-fidelity framework for adipose-brain communicationAdipoCode：脂肪-大脑通讯的信息保真度框架DOI: 10.1016/j.tem.2026.09.014
European journal of pharmacology IF: 04.700Ahead of Print.No.18Rosmarinic acid alleviates renal tubular injury in obesity-related hypertension by inhibiting the IL-18R1/MYD88/IRAK4 pathway迷迭香酸通过抑制IL-18R1/MYD88/IRAK4通路减轻肥胖相关高血压肾小管损伤DOI: 10.1016/j.ejphar.2026.179404
Eur J Obstet Gynecol Reprod Biol IF: 01.900Ahead of Print.No.19Age modifies the association between waist circumference and stress urinary incontinence in women: A cross-sectional NHANES study年龄对女性腰围与压力性尿失禁之间关联的修饰作用：一项NHANES横断面研究DOI: 10.1016/j.ejogrb.2026.115479
Lancet Diabetes Endocrinol IF: 41.800Ahead of Print.No.20Multidisciplinary care of pituitary adenomas垂体腺瘤的多学科协作诊疗DOI: 10.1016/S2213-8587(26)00252-4
Cardiovascular Diabetology IF: 10.600Ahead of Print.No.21Triglyceride-glucose normalized creatinine-to-cystatin C ratio (TyG-NCCR) predicts cardiovascular-kidney-metabolic syndrome (CKM) stage progression: evidence from CHARLS and UK biobank甘油三酯-葡萄糖归一化肌酐与胱抑素C比值（TyG-NCCR）预测心血管-肾脏-代谢综合征（CKM）分期进展：来自CHARLS和英国生物样本库的证据DOI: 10.1186/s12933-026-03406-7
ACS Appl Mater Interfaces IF: 08.200Ahead of Print.No.22Interface-Programmed Growth of High-Aspect-Ratio 1D Ni-MOF Nanofibers on MXene for Wearable Enzyme-Free Glucose Sensing界面编程生长高长径比一维Ni-MOF纳米纤维于MXene用于可穿戴无酶葡萄糖传感DOI: 10.1021/acsami.6c14970
Medicine IF: 01.400Volume 105, Issue 41No.23Prediction of cardiovascular event risk within 90 days in patients with hypertension: A study based on random forest and nomogram models高血压患者90天内心血管事件风险预测：基于随机森林和列线图模型的研究DOI: 10.1097/MD.0000000000050797
Medicine IF: 01.400Volume 105, Issue 41No.24Integrative bioinformatics analysis of Lianmei granules in diabetic nephropathy: Epidemiological and molecular insights连梅颗粒治疗糖尿病肾病的整合生物信息学分析：流行病学与分子洞察DOI: 10.1097/MD.0000000000051011
Int Urol Nephrol IF: 01.900Ahead of Print.No.25Heterogeneous 30-day readmission risk in diabetic kidney disease: a nationwide analysis stratified by phenotype, age, and socioeconomic status糖尿病肾病30天再入院风险的异质性：基于表型、年龄和社会经济地位分层的全国性分析DOI: 10.1007/s11255-026-05415-7
Human Reproduction Update IF: 16.100Ahead of Print.No.26Lifestyle interventions for cardiometabolic health in women with polycystic ovary syndrome: a systematic review and network meta-analysis多囊卵巢综合征女性心脏代谢健康的生活方式干预：系统综述与网络荟萃分析DOI: 10.1093/humupd/dmag032
Medicine IF: 01.400Volume 105, Issue 41No.27Cumulative exposure to the remnant cholesterol inflammation index and incident diabetes mellitus in middle-aged and elderly Chinese adults: A nationwide cohort study from CHARLS残余胆固醇炎症指数累积暴露与中国中老年人群新发糖尿病：来自CHARLS的全国性队列研究DOI: 10.1097/MD.0000000000051063
Medicine IF: 01.400Volume 105, Issue 41No.28Association of uric acid-to-albumin ratio with diabetic kidney disease: A cross-sectional study尿酸与白蛋白比值与糖尿病肾病的关联：一项横断面研究DOI: 10.1097/MD.0000000000051061
Medicine IF: 01.400Volume 105, Issue 41No.29Potato and warm moist compresses to accelerate healing of limb swelling and bruising after venous stent placement: A case report马铃薯联合温热湿敷加速静脉支架置入术后肢体肿胀和瘀斑愈合：一例病例报告DOI: 10.1097/MD.0000000000051049
CHE IF: 03.500Volume 48, Issue 1, Page 2603463-2603463No.30Association between Chinese visceral adiposity index and prevalent hypertension among older adults in rural China: A cross-sectional study中国内脏脂肪指数与中国农村老年人高血压患病率的关联：一项横断面研究DOI: 10.1080/10641963.2026.2744634
Medicine IF: 01.400Volume 105, Issue 41No.31The effect of cognitive behavioral therapy for sleep and glycemic outcomes in people with diabetes: A systematic review and meta-analysis认知行为疗法对糖尿病患者睡眠和血糖结局的影响：系统评价和荟萃分析DOI: 10.1097/MD.0000000000050890
Medicine IF: 01.400Volume 105, Issue 41No.32Association between neutrophil percentage-to-albumin ratio and all-cause mortality in stroke survivors stratified by triglyceride-glucose index: A prospective observational study based on the NHANES database from 1999 to 2018中性粒细胞百分比与白蛋白比值与卒中幸存者全因死亡率之间的关联：基于1999至2018年NHANES数据库的前瞻性观察性研究，按甘油三酯-葡萄糖指数分层DOI: 10.1097/MD.0000000000050968
Sleep & breathing IF: 02.000Volume 30, Issue 5No.33Association between sleep impairment and gestational diabetes mellitus subtypes: A prospective cohort study睡眠障碍与妊娠期糖尿病亚型之间的关联：一项前瞻性队列研究DOI: 10.1007/s11325-026-03823-8
Graefes Arch Clin Exp Ophthalmol IF: 02.300Ahead of Print.No.34Identification of novel lncRNAs potentially associated with diabetic retinopathy based on machine learning prediction基于机器学习预测鉴定与糖尿病视网膜病变潜在相关的新型lncRNADOI: 10.1007/s00417-026-07545-1
Diabetes therapy IF: 02.600Ahead of Print.No.35Impact of Ascorbic Acid and Exercise on Accuracy of a Glucose Monitoring System with GDH-FAD Technology in Adult Patients with Type 1 Diabetes Mellitus: A Double-Blinded, Randomized Trial抗坏血酸和运动对采用GDH-FAD技术的血糖监测系统在成人1型糖尿病患者中准确性的影响：一项双盲随机试验DOI: 10.1007/s13300-026-01918-9
Medicine IF: 01.400Volume 105, Issue 41No.36Short-term clinical efficacy and recorded adverse events of semaglutide combined with dapagliflozin in patients with type 2 diabetes mellitus and chronic kidney disease司美格鲁肽联合达格列净治疗2型糖尿病合并慢性肾脏病患者的短期临床有效性和记录的不良事件DOI: 10.1097/MD.0000000000051019
Journal of food science IF: 03.400Volume 91, Issue 10No.37Ultrasound-Assisted Flash Extraction of Juglans cathayensis Polysaccharides and Their Phosphorylation Treatment: Structural Characterization, Antioxidant, and Hypoglycemic Activities超声辅助闪式提取Juglans cathayensis多糖及其磷酸化处理：结构表征、抗氧化和降血糖活性DOI: 10.1111/1750-3841.71528
Medicine IF: 01.400Volume 105, Issue 41No.38Genetic risk factors and causal associations with sudden cardiac arrest: A Mendelian randomization study心脏骤停的遗传风险因素及因果关联：一项孟德尔随机化研究DOI: 10.1097/MD.0000000000050928
Medicine IF: 01.400Volume 105, Issue 41No.39Association between the non-HDL-c to HDL-c ratio and mortality risk in cardiorenal syndrome: A population-based study from 1999 to 2018 NHANES非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值与心肾综合征死亡风险的关联：基于1999至2018年NHANES的人群研究DOI: 10.1097/MD.0000000000051101
Medicine IF: 01.400Volume 105, Issue 41No.40Risk factors for post-PCI restenosis in patients with coronary heart disease and the development and validation of a nomogram prediction model冠心病患者PCI术后再狭窄的危险因素及列线图预测模型的开发与验证DOI: 10.1097/MD.0000000000050841
Clinical kidney journal IF: 04.600Ahead of Print.No.41Cost-effectiveness of dapagliflozin for chronic kidney disease with and without diabetes in China达格列净治疗中国伴糖尿病和不伴糖尿病的慢性肾脏病的成本效果分析DOI: 10.1093/ckj/sfag354
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.42Cross-sectional associations and incremental discrimination of inflammatory and lipid-derived indices for prevalent coronary heart disease in type 2 diabetes炎症与脂质衍生指标对2型糖尿病中流行性冠心病的横断面关联及增量判别能力DOI: 10.3389/fendo.2026.1961170
Climacteric : IF: 03.200Ahead of Print.No.43Non-linear association between body roundness index and menopausal symptoms in perimenopausal and postmenopausal women身体圆度指数与围绝经期及绝经后女性更年期症状之间的非线性关联DOI: 10.1080/13697137.2026.2728616
Frontiers in psychiatry IF: 03.200Volume 17, Issue No.44Psychological resilience profiles and their psychosocial correlates among adults with prediabetes: a latent profile analysis糖尿病前期成人的心理韧性潜在剖面及其心理社会相关因素：一项潜在剖面分析DOI: 10.3389/fpsyt.2026.1934725
Frontiers in immunology IF: 05.900Volume 17, Issue No.45Before-treatment body mass index as a prognostic factor in cancer patients receiving immune checkpoint inhibitors: a systematic review and dose-response meta-analysis治疗前体重指数作为接受免疫检查点抑制剂癌症患者的预后因素：系统评价与剂量-反应荟萃分析DOI: 10.3389/fimmu.2026.1921470
Frontiers in oncology IF: 03.300Volume 16, Issue No.46Effect of BMI-stratified management based on the meridian-lymph axis theory on lower extremity lymphedema after gynecological cancer surgery: a randomized controlled trial基于经络-淋巴轴理论的BMI分层管理对妇科癌症术后下肢淋巴水肿的影响：一项随机对照试验DOI: 10.3389/fonc.2026.1900880
J Natl Cancer Inst IF: 07.200Ahead of Print.No.47The early-onset pancreatic cancer paradox: a systematic review and meta-analysis早发性胰腺癌悖论：一项系统综述和荟萃分析DOI: 10.1093/jnci/djag373
Radiology IF: 15.200Volume 321, Issue 1No.48Cardiovascular Magnetic Resonance derived Myocardial Strain: Applications, Acquisition Techniques, Analysis, and Reporting. A Scientific Statement of the Society for Cardiovascular Magnetic Resonance, Radiological Society of North America, and European Association of Cardiovascular Imaging of the ESC心血管磁共振衍生心肌应变：应用、采集技术、分析与报告。SCMR、RSNA与ESC EACVI科学声明DOI: 10.1148/radiol.261385
Small IF: 12.100Ahead of Print.No.49In Situ Oxygen-Releasing Microneedle Regulates Hypoxic Microenvironment and Promotes Angiogenesis Through MEK1/2-ERK1/2 Pathway for Diabetic Infected Wound Healing原位释氧微针通过MEK1/2-ERK1/2通路调控缺氧微环境并促进血管生成以治疗糖尿病感染性伤口愈合DOI: 10.1002/smll.76180
Current pharmaceutical design IF: 02.800Ahead of Print.No.50Development of Selenized Phytosomes for Sustained Release of Berberine and Synergistic Hypoglycemic Effect硒化小檗碱磷脂复合物的开发及其缓释与协同降血糖作用DOI: 10.2174/0113816128512130260922075457
Zhejiang Da Xue Xue Bao Yi Xue BanAhead of Print.No.51[Gut microbiota-mediated FGF metabolic axis in the pathogenesis, prevention and treatment of various diseases]肠道菌群介导的FGF代谢轴在多种疾病发病、预防和治疗中的作用DOI: 10.3724/zdxbyxb-2026-0306
Nanomedicine IF: 03.900Ahead of Print.No.52mRNA-based nanomedicine for diabetic wound repair: advances in LNP delivery, immune modulation, and regenerative pathways基于mRNA的纳米药物用于糖尿病创面修复：脂质纳米颗粒递送、免疫调节与再生通路的研究进展DOI: 10.1080/17435889.2026.2744280
ACS omega IF: 04.300Volume 11, Issue 35No.53Tyr-Mpa Proximity-Induced Atypical tert-Butyl Intramolecular Migration in Desmopressin: Mechanistic Elucidation of a Site-Selective Impurity and Its Suppression Strategy去氨加压素中Tyr-Mpa邻近诱导的非典型叔丁基分子内迁移：位点选择性杂质的机理阐明及其抑制策略DOI: 10.1021/acsomega.6c07280
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.54Social network characteristics, self-management behavior, and the mediating role of self-efficacy among diabetes patients: a multicenter cross-sectional study糖尿病患者的社会网络特征、自我管理行为及自我效能的中介作用：一项多中心横断面研究DOI: 10.3389/fendo.2026.1934060
ACS omega IF: 04.300Volume 11, Issue 39No.55ZIF-8-Based Smart-Responsive Nanocomposites for Cutaneous Wound Healing: A Review基于ZIF-8的智能响应纳米复合材料用于皮肤伤口愈合：综述DOI: 10.1021/acsomega.6c05811
BMJ public healthVolume 4, Issue 4No.56Shifts in socioeconomic status alter cardiovascular disease risk and mortality through modulating Life's Crucial 9: a prospective cohort study of UK Biobank participants社会经济地位变化通过调节生命关键9项影响心血管疾病风险和死亡率：英国生物样本库参与者的前瞻性队列研究DOI: 10.1136/bmjph-2025-004299
Front Bioeng Biotechnol IF: 04.800Volume 14, Issue No.57Clinical trials on 3D bioprinted scaffolds for lower extremity vascular, diabetic and pressure ulcers: a systematic review3D生物打印支架治疗下肢血管性、糖尿病性和压力性溃疡的临床试验：一项系统综述DOI: 10.3389/fbioe.2026.1912135
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.58Case Report: Treatment of fulminant paraquat poisoning in a 32-week pregnant patient: a case report exploring the potential role of estrogen病例报告：32周妊娠患者暴发性百草枯中毒的治疗——探讨雌激素潜在作用的病例报告DOI: 10.3389/fphar.2026.1864030
Frontiers in oncology IF: 03.300Volume 16, Issue No.59Beyond symptoms: wearable digital biomarkers for subclinical detection of chemotherapy-induced peripheral neuropathy超越症状：用于化疗诱导的周围神经病变亚临床检测的可穿戴数字生物标志物DOI: 10.3389/fonc.2026.1959858
Journal of biomedical optics IF: 02.900Volume 31, Issue 10No.60SEFCA-Net: a semantic-edge-frequency cross-attention network for diabetic retinopathy lesion segmentationSEFCA-Net：用于糖尿病视网膜病变病灶分割的语义-边缘-频率交叉注意力网络DOI: 10.1117/1.JBO.31.10.106002
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.61Association between leukocyte-derived inflammatory biomarkers and diabetic retinopathy progression in patients with type 2 diabetes mellitus白细胞衍生炎症生物标志物与2型糖尿病患者糖尿病视网膜病变进展之间的关联DOI: 10.3389/fendo.2026.1926059
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.62Altered resting-state brain function in diabetic retinopathy: a meta-analysis of combined transcriptome-neuroimaging study糖尿病视网膜病变中静息态脑功能改变：转录组-神经影像联合研究的荟萃分析DOI: 10.3389/fendo.2026.1928717
Cancer research IF: 16.600Ahead of Print.No.63INSR Armoring Protects CAR-NK and CAR-T Cells Against Tumor Stroma-Induced CAR Shedding by Maintaining Cholesterol HomeostasisINSR装甲保护CAR-NK和CAR-T细胞通过维持胆固醇稳态抵抗肿瘤基质诱导的CAR脱落DOI: 10.1158/0008-5472.CAN-26-1047
ACS omega IF: 04.300Volume 11, Issue 39No.64The PTPN1/N2 Peptide Inhibitor Achieves Potent, Long-Acting Glycemic Control and Weight-Loss Dual Efficacy in MicePTPN1/N2肽抑制剂在小鼠中实现强效长效血糖控制与减重双重疗效DOI: 10.1021/acsomega.6c05930
Current medical imaging reviews IF: 01.100Ahead of Print.No.65Myocardial Work Assessment in Type 2 Diabetic Kidney Disease using Left Ventricular Pressure-Strain Loops应用左心室压力-应变环评估2型糖尿病肾病患者的心肌做功DOI: 10.2174/0115734056481754260925093639
J Diabetes Investig IF: 03.000Ahead of Print.No.66The cholesterol, high-density lipoprotein, and glucose index and its derivatives related to obesity and inflammation as novel metabolic markers for predicting new-onset cardiovascular-liver-metabolic multimorbidity: A prospective cohort study胆固醇、高密度脂蛋白和葡萄糖指数及其与肥胖和炎症相关的衍生指标作为预测新发心血管-肝脏-代谢多病共存的新型代谢标志物：一项前瞻性队列研究DOI: 10.1111/jdi.70462
Metab Syndr Relat Disord IF: 01.700Ahead of Print.No.67Triglyceride-Glucose Index and 10-Year Atherosclerotic Cardiovascular Disease Risk: Associations of Obesity-Related Indices in Two Nationally Representative Populations甘油三酯-葡萄糖指数与10年动脉粥样硬化性心血管疾病风险：两个全国代表性人群中肥胖相关指数的关联DOI: 10.1177/15578518261496117
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.68Combined assessment of body mass index and triglyceride-glucose index reveals metabolic risk phenotypes associated with semen quality impairment体重指数与甘油三酯-葡萄糖指数的联合评估揭示与精液质量损害相关的代谢风险表型DOI: 10.3389/fendo.2026.1960020
Environ Health Perspect IF: 09.800Volume 134, Issue 6No.69Sex-Specific Associations Between Per- and Polyfluoroalkyl Substances and the Risk of Type 2 Diabetes: The Role of Genetic Susceptibility and Lipid Metabolism全氟和多氟烷基物质与2型糖尿病风险之间的性别特异性关联：遗传易感性和脂质代谢的作用DOI: 10.1021/EHP.6c00071
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.70Risk factors and nomogram for gallbladder stones in patients with type 2 diabetes mellitus: a retrospective study based on LASSO regression2型糖尿病患者胆囊结石的危险因素及列线图：基于LASSO回归的回顾性研究DOI: 10.3389/fendo.2026.1908086
J Int Med Res IF: 01.500Volume 54, Issue 10No.71Associations between advanced lung cancer inflammation index score and kidney outcomes in intensive care unit patients with diabetes: A retrospective cohort study晚期肺癌炎症指数评分与重症监护室糖尿病患者肾脏结局之间的关联：一项回顾性队列研究DOI: 10.1177/03000605261494871
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.72Maternal HIF1A-IGFBP2 dysregulation links endometriosis to gestational diabetes: a prospective cohort study母体HIF1A-IGFBP2失调将子宫内膜异位症与妊娠期糖尿病联系起来：一项前瞻性队列研究DOI: 10.3389/fendo.2026.1948558
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.73SGLT2 inhibitors, semaglutide, and finerenone in diabetic kidney disease: a Bayesian network meta-analysisSGLT2抑制剂、司美格鲁肽与非奈利酮治疗糖尿病肾脏病：一项贝叶斯网络荟萃分析DOI: 10.3389/fphar.2026.1882227
Frontiers in public health IF: 03.400Volume 14, Issue No.74Multidimensional characteristics of body composition in older adults and their relationship to common chronic diseases老年人身体成分的多维特征及其与常见慢性病的关系DOI: 10.3389/fpubh.2026.1905131
Cardiovascular Therapeutics IF: 03.400Volume 2026, Issue 1, Page 5568664-5568664No.75Naringenin Attenuates Diabetic Cardiac Injury via SIRT1 Activation in Streptozotocin-Induced Rats柚皮素通过激活SIRT1减轻链脲佐菌素诱导的糖尿病大鼠心脏损伤DOI: 10.1155/cdr/9581618
Frontiers in public health IF: 03.400Volume 14, Issue No.76Knowledge, attitudes, and practices of parents regarding childhood weight management and associated factors in Southwest China: a cross-sectional study中国西南地区家长对儿童体重管理的知识、态度和实践及相关因素：一项横断面研究DOI: 10.3389/fpubh.2026.1907801
Frontiers in public health IF: 03.400Volume 14, Issue No.77BMI moderates the association between physical fitness and spherical equivalent in Chinese college students: a cross-sectional study体重指数调节中国大学生体力活动与等效球镜度之间的关联：一项横断面研究DOI: 10.3389/fpubh.2026.1937229
Nature communications IF: 15.700Volume 17, Issue 1No.78CNIH4 regulates systemic metabolism and exercise adaptations in male mice primarily through the modulation of β-adrenergic receptor traffickingCNIH4通过调节β-肾上腺素能受体转运调控雄性小鼠全身代谢和运动适应DOI: 10.1038/s41467-026-77408-0
Frontiers in medicine IF: 03.000Volume 13, Issue No.79MoCA-screen-positive status differs across intraocular pressure subtypes of primary open-angle glaucomaMoCA筛查阳性状态在原发性开角型青光眼不同眼压亚型间存在差异DOI: 10.3389/fmed.2026.1912812
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.80Development and comparative evaluation of machine learning algorithms and Cox regression for predicting fasting plasma glucose-defined incident prediabetes: a longitudinal cohort study机器学习算法与Cox回归预测空腹血糖定义的初发糖尿病前期的开发与比较评估：一项纵向队列研究DOI: 10.3389/fendo.2026.1862258
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.81Clinical and inflammatory changes following routine scaling and root planing in periodontitis patients with and without diabetes: a prospective observational cohort study伴与不伴糖尿病的牙周炎患者接受常规龈下刮治和根面平整后的临床与炎症变化：一项前瞻性观察性队列研究DOI: 10.3389/fendo.2026.1937181
EHJ-CI IF: 06.600Ahead of Print.No.82Cardiovascular magnetic resonance derived myocardial strain: applications, acquisition techniques, analysis, and reporting心血管磁共振衍生心肌应变：应用、采集技术、分析与报告DOI: 10.1093/ehjci/jeag228
Annals of medicine IF: 04.300Volume 58, Issue 1No.83Development and validation of a nomogram for predicting the probability of arthroplasty in patients with osteonecrosis of the femoral head after fibular strut grafting预测股骨头坏死患者腓骨支撑植骨术后关节置换概率的列线图开发与验证DOI: 10.1080/07853890.2026.2734061
J Sci Food Agric IF: 03.500Ahead of Print.No.84Dietary aqueous extract of Astragalus sinicus alleviates obesity by reshaping gut microbiota and metabolism紫云英膳食水提物通过重塑肠道菌群和代谢缓解肥胖DOI: 10.1002/jsfa.71149
Xibao yu fenzi mianyixue zazhiVolume 42, Issue 10No.85[IGFBP-4 improves synovitis by reducing M1 polarization of macrophages via the Wnt/β-catenin pathway]IGFBP-4通过Wnt/β-catenin通路减少巨噬细胞M1极化改善滑膜炎https://pubmed.ncbi.nlm.nih.gov/42851053
Liver international IF: 05.200Volume 46, Issue 11No.86C. butyricum Combined With Resmetirom Provides Therapeutic Benefits in MASH Associated With Gut-Liver-Brain Axis Modulation丁酸梭菌联合resmetirom在MASH中提供治疗获益并与肠-肝-脑轴调节相关DOI: 10.1111/liv.70905
Advanced science IF: 14.100Ahead of Print.No.87Tumor-Intrinsic HEXB Drives Endothelial-To-Mesenchymal Transition and Confers Resistance to Anti-Angiogenic Therapy in Glioblastoma肿瘤内在HEXB驱动内皮-间质转化并赋予胶质母细胞瘤抗血管生成治疗耐药性DOI: 10.1002/advs.78208
Renal failure IF: 03.000Volume 48, Issue 1No.88A bibliometric analysis of trace elements and diabetic kidney disease: scientific hotspots and research evolution微量元素与糖尿病肾病的文献计量学分析：科学热点与研究演进DOI: 10.1080/0886022X.2026.2736897
Front Cell Infect Microbiol IF: 04.800Volume 16, Issue No.89Quantitative mapping of gut microbiota feature importance to TCM syndrome elements in clinical T2DM stages肠道微生物特征重要性对临床T2DM阶段中医证候要素的定量映射DOI: 10.3389/fcimb.2026.1910757
Frontiers in medicine IF: 03.000Volume 13, Issue No.90Association between triglyceride glucose-body mass index and diabetic kidney disease in hospitalized patients with type 2 diabetes mellitus: a retrospective cross-sectional study甘油三酯葡萄糖-体重指数与住院2型糖尿病患者糖尿病肾脏病之间的关联：一项回顾性横断面研究DOI: 10.3389/fmed.2026.1840269
IF: 00.700Volume 36, Issue 10No.91Association of Hepatitis B Virus Ribonucleic Acid with Type 2 Diabetes Mellitus in Chronic Hepatitis B慢性乙型肝炎中乙型肝炎病毒核糖核酸与2型糖尿病的关联DOI: 10.29271/jcpsp.2026.10.1260
Microbiome IF: 12.700Volume 14, Issue 1No.92Inulin alleviates vascular cognitive impairment by restoring prefrontal GABAergic function via microbiota-SCFA-GPR41/43 axis菊粉通过微生物-短链脂肪酸-GPR41/43轴恢复前额叶GABA能功能以缓解血管性认知障碍DOI: 10.1186/s40168-026-02469-8
Signal Transduct Target Ther IF: 52.700Volume 11, Issue 1No.93SARS-CoV-2 seeds IAPP aggregation and β-cell failureSARS-CoV-2作为IAPP聚集的种子导致β细胞衰竭DOI: 10.1038/s41392-026-02914-y
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.94Experiences and perceived determinants of healthcare-related time toxicity among women with gestational diabetes mellitus: a qualitative study妊娠期糖尿病女性医疗相关时间毒性的体验与感知决定因素：一项质性研究DOI: 10.3389/fendo.2026.1947845
Xibao yu fenzi mianyixue zazhiVolume 42, Issue 10No.95[Effects of human placental mesenchymal stem cell (hPDMSC)-derived exosome (PdE) shuttling miR-144-3p on vascular endothelial cell dysfunction in gestational diabetes mellitus (GDM)]人胎盘间充质干细胞来源外泌体转运miR-144-3p对妊娠期糖尿病血管内皮细胞功能障碍的影响https://pubmed.ncbi.nlm.nih.gov/42851054
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.96Linking the triglyceride-glucose index to major adverse cardiocerebrovascular events in individuals with cardiovascular-kidney-metabolic syndrome: insights from an aggregate-data systematic review and dose-response meta-analysis甘油三酯-葡萄糖指数与心血管-肾脏-代谢综合征患者主要不良心脑血管事件的关联：基于聚合数据的系统评价和剂量-反应荟萃分析的见解DOI: 10.3389/fendo.2026.1959631
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.97Integration of ultra-widefield optical coherence tomography angiography images and clinical indicators for identifying early-stage diabetic retinopathy in type 2 diabetes整合超广角光学相干断层扫描血管成像图像与临床指标识别2型糖尿病早期糖尿病视网膜病变DOI: 10.3389/fendo.2026.1941613
Frontiers in nutrition IF: 05.100Volume 13, Issue No.98Cholesterol-modified prognostic nutritional index: a novel nutritional biomarker for prevalent diabetic retinopathy in patients with type 2 diabetes mellitus胆固醇修正预后营养指数：2型糖尿病患者中糖尿病视网膜病变的新型营养生物标志物DOI: 10.3389/fnut.2026.1942512
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.99Case Report: Pituitary apoplexy temporally associated with acute alcohol intoxication, presenting as complete oculomotor nerve palsy in an SF-1 lineage gonadotroph PitNET病例报告：与急性酒精中毒时间相关的垂体卒中，表现为SF-1谱系促性腺激素细胞垂体神经内分泌肿瘤中的完全性动眼神经麻痹DOI: 10.3389/fendo.2026.1919724
BJOG IF: 04.700Ahead of Print.No.100Bidirectional Mediation Effects of Body Mass Index and Inflammatory Markers on Assisted Reproductive Outcomes in Women With Polycystic Ovary Syndrome体重指数与炎症标志物对多囊卵巢综合征女性辅助生殖结局的双向中介效应DOI: 10.1111/1471-0528.70344
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BMJ open IF: 02.300Volume 16, Issue 10No.05Association of life course type 2 diabetes duration with adverse cardiac structure independent of current glycaemia in the British MRC National Survey of Health and Development Birth Cohort英国MRC健康与发展国家调查出生队列中生命历程2型糖尿病病程与不良心脏结构的关联独立于当前血糖水平DOI: 10.1136/bmjopen-2025-113002
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JMIR formative research IF: 02.100Volume 10, Issue No.18Association Between Wrist-Worn Device-Estimated Sleep Efficiency and Hand Grip Strength in Older Outpatients With Cardiometabolic Diseases: Cross-Sectional Study腕戴设备估算的睡眠效率与患有心血管代谢疾病的老年门诊患者握力之间的关联：横断面研究DOI: 10.2196/95303
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Diabetes Res Clin Pract IF: 07.400Ahead of Print.No.25Utilization of serum cystatin C for early detection of chronic kidney disease in Type 2 diabetes mellitus and hypertension: A systematic review血清胱抑素C在2型糖尿病和高血压患者中早期检测慢性肾脏病的应用：一项系统综述DOI: 10.1016/j.diabres.2026.113545
JMIR formative research IF: 02.100Volume 10, Issue No.26Individualized Therapy Optimization for Type 2 Diabetes: Retrospective Study of Model Development, Internal Validation, and Physician Evaluation2型糖尿病的个体化治疗优化：模型开发、内部验证与医生评估的回顾性研究DOI: 10.2196/92877
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Tierarztl Prax Ausg K Kleintiere Heimtiere IF: 00.500Volume 54, Issue 5No.33[Diabetic ketoacidosis in cats: pathogenesis and diagnosis]猫糖尿病酮症酸中毒：发病机制与诊断DOI: 10.1055/a-2894-2205
Endocrine practice IF: 04.600Ahead of Print.No.34Long-term Safety and Efficacy of Once-Weekly Lonapegsomatropin in Adults With Growth Hormone Deficiency: Results From a 52-Week Open-Label Extension Trial每周一次Lonapegsomatropin在成人生长激素缺乏症中的长期安全性和有效性：一项52周开放标签扩展试验结果DOI: 10.1016/j.eprac.2026.08.028
Ophthalmology IF: 09.500Ahead of Print.No.35Prevalence of Diabetic Retinopathy and Cardiovascular Risk Factors Among Diverse Hispanic/Latino Adults: HCHS/SOL and SOL Ojos Results不同西班牙裔/拉丁裔成年人中糖尿病视网膜病变和心血管危险因素的患病率：HCHS/SOL和SOL Ojos研究结果DOI: 10.1016/j.ophtha.2026.09.037
Obes Res Clin Pract IF: 02.300Ahead of Print.No.36Costs of two-step MASLD screening using ALT and elastography in children with overweight and obesity超重和肥胖儿童采用ALT和弹性成像进行两步法MASLD筛查的成本DOI: 10.1016/j.orcp.2026.10.003
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BMJ open IF: 02.300Volume 16, Issue 10No.38Comparative health outcomes of buprenorphine versus methadone treatment for opioid use disorder: a retrospective propensity score-matched cohort study in the global federated electronic health record network丁丙诺啡与美沙酮治疗阿片类药物使用障碍的健康结局比较：全球联邦电子健康记录网络中的回顾性倾向评分匹配队列研究DOI: 10.1136/bmjopen-2026-122747
JMIR formative research IF: 02.100Volume 10, Issue No.39Feasibility, Acceptability, and Appropriateness of an 8-Week Supervised Aerobic Exercise Intervention for Adults With Epilepsy: Pilot Randomized Controlled Trial8周监督有氧运动干预对成人癫痫患者的可行性、可接受性和适当性：试点随机对照试验DOI: 10.2196/97392
JHEP reports IF: 07.500Ahead of Print.No.40The landscape of hepatocellular carcinoma recurrence after liver transplantation: a nationwide 14-year study肝细胞癌肝移植术后复发的全景：一项全国性14年研究DOI: 10.1016/j.jhepr.2026.102062
Clinical nutrition ESPEN IF: 02.600Ahead of Print.No.41Slower Eating Prolongs Intestinal Transit Time and Reduces Fecal Short-Chain Fatty Acids in Healthy Men: A Preliminary Randomized Crossover Trial较慢进食延长健康男性肠道转运时间并降低粪便短链脂肪酸：一项初步随机交叉试验DOI: 10.1016/j.clnesp.2026.105165
Heart Rhythm IF: 05.700Ahead of Print.No.42Nuclear magnetic resonance-derived lipoprotein profile and risk of atrial tachyarrhythmia recurrence after catheter ablation: a case-cohort design within the PREDIMAR trial核磁共振衍生的脂蛋白谱与导管消融后房性快速性心律失常复发风险：PREDIMAR试验中的病例-队列设计DOI: 10.1016/j.hrthm.2026.10.002
CMGH IF: 07.400Ahead of Print.No.43A microbiota-driven CCL25-CCR9 axis reprograms intestinal ILC2s in the distal small intestine to promote metabolic dysfunction in obesity微生物驱动的CCL25-CCR9轴重编程远端小肠ILC2促进肥胖代谢功能障碍DOI: 10.1016/j.jcmgh.2026.101919
J Allergy Clin Immunol Pract IF: 06.600Ahead of Print.No.44Inhaled, nasal and topical corticosteroid burden and association with corticosteroid-associated adverse events吸入、鼻用和局部外用皮质类固醇负担及其与皮质类固醇相关不良事件的关联DOI: 10.1016/j.jaip.2026.09.029
J Nutr Biochem IF: 04.900Ahead of Print.No.45Ketogenic diet induces metabolic remodeling and alters myogenic markers in skeletal muscle of obese male mice subjected to medial meniscus destabilization生酮饮食诱导接受内侧半月板失稳术的肥胖雄性小鼠骨骼肌代谢重塑并改变肌源性标志物DOI: 10.1016/j.jnutbio.2026.110515
Food chemistry IF: 09.800Ahead of Print.No.46Cold-gelation-related functionality of hot-air-popped flours from pigmented popcorn (Zea mays var. 'Everta'), sorghum (Sorghum bicolor), and amaranth (Amaranthus sp.)热风爆化有色爆米花玉米、高粱和苋菜籽粉的冷凝胶化相关功能特性DOI: 10.1016/j.foodchem.2026.151387
Diabetes Technol Ther IF: 06.300Ahead of Print.No.47Roadmap to Fully Closing the Loop to Optimize Health in Type 1 Diabetes完全闭环优化1型糖尿病健康的路线图DOI: 10.1177/15209156261496643
Endocrine practice IF: 04.600Ahead of Print.No.48Weight Management in Obesity-Associated Sleep-Disordered Breathing: Mechanisms, Clinical Management, and Emerging Therapies肥胖相关睡眠呼吸障碍中的体重管理：机制、临床管理与新兴疗法DOI: 10.1016/j.eprac.2026.09.120
Advances in Medical Sciences IF: 02.600Ahead of Print.No.49Tirzepatide persistence, adherence, and dose escalation in a real-world setting with high out-of-pocket costs: a Polish cohort study在高自付费用真实世界环境中替尔泊肽的持续性、依从性和剂量递增：一项波兰队列研究DOI: 10.1016/j.advms.2026.10.005
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Hypertension Research IF: 04.600Ahead of Print.No.52Efficacy and safety of esaxerenone versus angiotensin II receptor blockers in older patients with hypertension, with and without type 2 diabetes mellitus: a predefined subgroup analysis of the ESCORT-HT study - Hypertension Research艾沙利酮与血管紧张素II受体阻滞剂在老年高血压患者（伴或不伴2型糖尿病）中的有效性和安全性：ESCORT-HT研究预设亚组分析DOI: 10.1038/s41440-026-02779-2
PLOS mental healthVolume 3, Issue 10No.53Mental health care utilization among middle-aged and older U.S. adults: Findings from the National Health Interview Survey美国中老年人群的心理健康服务利用情况：来自National Health Interview Survey的发现DOI: 10.1371/journal.pmen.0000744
JAMA Network Open IF: 09.700Volume 9, Issue 10No.54Urolithin A and Endothelial and Cerebrovascular Function in Middle-Aged Adults With Obesity: A Randomized Clinical Trial尿石素A与中年肥胖成人的内皮和脑血管功能：一项随机临床试验DOI: 10.1001/jamanetworkopen.2026.38047
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Medicine IF: 01.400Volume 105, Issue 41No.56National trends in chronic kidney disease prevalence by sleep duration in South Korea, 2007 to 2022: A nationwide cross-sectional study2007年至2022年韩国睡眠时长与慢性肾脏病患病率的全国趋势：一项全国性横断面研究DOI: 10.1097/MD.0000000000051053
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Diabetes IF: 07.500Ahead of Print.No.58Letter to the American Diabetes Association Board of Directors From Members of the Mentor Advisory Committee, ADA Pathway to Stop Diabetes Program美国糖尿病协会“终止糖尿病之路”项目导师咨询委员会成员致美国糖尿病协会董事会的信DOI: 10.2337/dbi26-0053
Medical teacher IF: 04.400Ahead of Print.No.59Teaching on demand: Exploring the role of AI in medical education podcasts按需教学：探索AI在医学教育播客中的作用DOI: 10.1080/0142159X.2026.2733139
International journal of cancer IF: 04.700Ahead of Print.No.60Persistent Health Disparities Among Adult Cancer Survivors成年癌症幸存者中持续存在的健康差异DOI: 10.1002/ijc.70770
J Am Soc Nephrol IF: 09.400Ahead of Print.No.61A Microsimulation of Eligibility for Cardiorenal Combination Treatment and Potential Deaths Averted心肾联合治疗的资格与潜在可预防死亡的微观模拟研究DOI: 10.1681/ASN.0000001287
Rev Endocr Metab Disord IF: 08.000Ahead of Print.No.62Bone health in diabetes mellitus糖尿病中的骨骼健康DOI: 10.1007/s11154-026-10091-0
Molecular biomedicine IF: 10.100Volume 7, Issue 1No.63An inducible co-stimulator ligand (ICOSL)-based peptide therapy for proteinuric kidney diseases targeting αvβ3 integrin基于诱导性共刺激分子配体（ICOSL）的靶向αvβ3整合素的肽类疗法用于蛋白尿性肾病DOI: 10.1186/s43556-026-00594-2
Surgery today IF: 01.600Ahead of Print.No.64Coronary bypass outcomes in chronic limb-threatening ischemia are significantly worse than in patients with non-critical lower extremity arterial disease慢性肢体威胁性缺血患者的冠状动脉搭桥术结局显著差于非危重下肢动脉疾病患者DOI: 10.1007/s00595-026-03499-3
PloS one IF: 02.600Volume 21, Issue 10No.65Self-care practices of people living with HIV and hypertension or diabetes comorbidities in low-and-middle income countries: A systematic review中低收入国家HIV合并高血压或糖尿病共病患者自我照护实践的系统综述DOI: 10.1371/journal.pone.0360076
Science advances IF: 12.500Volume 12, Issue 41No.66Carbonic anhydrase VIII regulates IP3R1-dependent Ca2+ signaling to coordinate insulin secretion and hepatic glucose production碳酸酐酶VIII调控IP3R1依赖性Ca2+信号以协调胰岛素分泌和肝葡萄糖生成DOI: 10.1126/sciadv.aeh4948
European neurology IF: 02.400Ahead of Print.No.67Idiopathic Intracranial Hypertension, Basic Concepts and Emerging Molecular, Genetic, and Immunological Therapies特发性颅内高压：基本概念与新兴分子、遗传及免疫治疗DOI: 10.1159/ene/acsag015
Neurology and therapy IF: 04.800Ahead of Print.No.68Migraine and Obesity: From Shared Mechanisms to Therapeutic Strategies偏头痛与肥胖：从共享机制到治疗策略DOI: 10.1007/s40120-026-01050-7
J Endocrinol Invest IF: 03.500Ahead of Print.No.69Neuroendocrine regulation of adipose partitioning in polyendocrine metabolic ovarian syndrome: the gut-brain-adipose axis多内分泌代谢性卵巢综合征中脂肪分布的神经内分泌调控：肠-脑-脂肪轴DOI: 10.1007/s40618-026-03047-3
Diabetologia IF: 10.200Ahead of Print.No.70Editorial Expression of Concern: Critical role of c-Kit in beta cell function: increased insulin secretion and protection against diabetes in a mouse model编辑关注声明：c-Kit在β细胞功能中的关键作用：小鼠模型中胰岛素分泌增加及糖尿病保护作用DOI: 10.1007/s00125-026-06894-0
Science advances IF: 12.500Volume 12, Issue 41No.71ALIX-dependent small extracellular vesicles from tissue-resident mesenchymal cells regulate pancreatic β cell proliferation in obesity肥胖状态下组织驻留间充质细胞来源的ALIX依赖性小细胞囊泡调控胰腺β细胞增殖DOI: 10.1126/sciadv.aei1333
Cerebrovascular Diseases IF: 01.500Ahead of Print.No.72Association of plasma D-dimer and B-type natriuretic peptide levels with acute ischemic stroke mechanism, severity, and outcome血浆D-二聚体和B型利钠肽水平与急性缺血性卒中机制、严重程度及结局的关联DOI: 10.1159/ced/accag040
Clin J Am Soc Nephrol IF: 07.100Volume 21, Issue 10No.73Cardiovascular and Kidney Outcomes following Sodium-Glucose Cotransporter 2 Inhibitor Initiation in CKD: A Swedish Nationwide Cohort Study慢性肾脏病患者启动钠-葡萄糖协同转运蛋白2抑制剂后的心血管与肾脏结局：一项瑞典全国性队列研究DOI: 10.2215/CJN.0000001160
Archiv der Pharmazie IF: 03.600Volume 359, Issue 10No.74Metabolic Stress Shifts the Function of KCa3.1 Channels in Pancreatic Beta Cells From a Regulator of Membrane Potential to a Proapoptotic Factor代谢应激将胰腺β细胞中KCa3.1通道的功能从膜电位调节因子转变为促凋亡因子DOI: 10.1002/ardp.70344
Diabetes therapy IF: 02.600Ahead of Print.No.75Associations of Glycemic Control, Age, and Sex with Diabetic Foot Risk and Active Foot Ulceration among Patients with Diabetes in Saudi Arabia: A Cross-Sectional Study沙特阿拉伯糖尿病患者血糖控制、年龄和性别与糖尿病足风险及活动性足溃疡的关联：一项横断面研究DOI: 10.1007/s13300-026-01923-y
Clin Transl Oncol IF: 02.500Ahead of Print.No.76EML4-ALK fusion rewires transcriptomic, miRNA, and CAF-associated programs in non-small cell lung cancerEML4-ALK融合重编程非小细胞肺癌的转录组、miRNA及CAF相关程序DOI: 10.1007/s12094-026-04569-1
JAMA Network Open IF: 09.700Volume 9, Issue 10No.77A Community-Based Behavioral Intervention and Body Mass Index in School-Aged Children: A Cluster Randomized Clinical Trial基于社区的行为干预与学龄儿童体重指数：一项整群随机临床试验DOI: 10.1001/jamanetworkopen.2026.38188
Urologia internationalis IF: 01.300Ahead of Print.No.78Renal Candidal Bezoar in an SGLT2 Inhibitor User with an Indwelling Ureteral Stent: A Case Report and Review of Literatures使用SGLT2抑制剂并留置输尿管支架患者发生肾念珠菌性结石：病例报告及文献综述DOI: 10.1159/uin/aewag035
Science advances IF: 12.500Volume 12, Issue 41No.79SMCHD1 is a target for gene activation therapy to treat Prader-Willi syndromeSMCHD1是治疗Prader-Willi综合征的基因激活疗法靶点DOI: 10.1126/sciadv.aej5702
PloS one IF: 02.600Volume 21, Issue 10No.80COlour vision assessment for the Detection of Early diabetic Retinopathy (CODER): A study protocol用于检测早期糖尿病视网膜病变的色觉评估（CODER）：一项研究方案DOI: 10.1371/journal.pone.0359653
Ophthalmology and therapy IF: 03.200Ahead of Print.No.81Study Design for ELARA, a Phase 3b Trial of Aflibercept 8 mg in Previously Treated Patients With Neovascular Age-Related Macular Degeneration or Diabetic Macular EdemaELARA研究设计：一项在经治新生血管性年龄相关性黄斑变性或糖尿病性黄斑水肿患者中评估阿柏西普8 mg的3b期试验DOI: 10.1007/s40123-026-01499-7
Clinical oral investigations IF: 03.100Volume 30, Issue 11No.82Oral microbiome alterations in individuals with type 1 diabetes: a systematic review1型糖尿病个体的口腔微生物组改变：一项系统综述DOI: 10.1007/s00784-026-07205-y
Archiv der Pharmazie IF: 03.600Volume 359, Issue 10No.83Integrated In Silico and In Vitro Investigation of Chromene Derivatives as Potential Antidiabetic Agents in 3T3-L1 Cells整合计算机模拟与体外研究探讨色烯衍生物在3T3-L1细胞中的潜在抗糖尿病作用DOI: 10.1002/ardp.70361
Medicine IF: 01.400Volume 105, Issue 41No.84The correlation between the rs2241767 variant and the plasma AdipoQ concentration in type 2 diabetes mellitus: A case - control studyrs2241767变异与2型糖尿病患者血浆AdipoQ浓度的相关性：一项病例对照研究DOI: 10.1097/MD.0000000000050985
Irish journal of medical science IF: 01.600Ahead of Print.No.85The relationship between pulse wave velocity and microvascular complications in patients with diabetes mellitus: a cross-sectional study糖尿病患者脉搏波速度与微血管并发症之间的关系：一项横断面研究DOI: 10.1007/s11845-026-04675-7
Aliment Pharmacol Ther IF: 06.700Volume 64, Issue 9No.86Clinical Outcomes After Percutaneous Coronary Intervention in Patients With Cirrhosis: A Multicentre National Study肝硬化患者经皮冠状动脉介入治疗后的临床结局：一项多中心全国性研究DOI: 10.1111/apt.70896
Transl Behav Med IF: 03.000Volume 16, Issue 1No.87Adaptations of an evidence-based intervention for child obesity treatment delivered in a home health setting: a brief report在家庭健康服务环境中实施的儿童肥胖治疗循证干预的适应性调整：简要报告DOI: 10.1093/tbm/ibag073
Journal of pediatric psychology IF: 02.100Ahead of Print.No.88Topical review: A conceptual framework for diabetes distress tolerance in transitional age youth with type 1 diabetes专题综述：过渡年龄期1型糖尿病青年糖尿病痛苦耐受性的概念框架DOI: 10.1093/jpepsy/jsag071
Yale J Biol Med IF: 03.900Volume 99, Issue 2No.89Stiff-Person Syndrome: A Comprehensive Review of a Rare Disease with Emphasis on Pathophysiology, Clinical Features, Diagnostic Challenges and Therapeutic Advances僵人综合征：罕见疾病的综合综述，重点关注病理生理学、临床特征、诊断挑战与治疗进展DOI: 10.59249/ADKE4751
JAMA IF: 55.000Ahead of Print.No.90FDA Authorizes First Continuous Ketone Monitor for DiabetesFDA批准首款用于糖尿病的连续酮体监测仪DOI: 10.1001/jama.2026.20013
Cent Eur J Public Health IF: 00.900Volume 34, Issue 3No.91Correction to: Comparing step count strategies: the impact of walking on cardiometabolic health in women with obesity (Vol. 34, Pg 80, 2026)更正：比较步数策略：步行对肥胖女性心脏代谢健康的影响（第34卷，第80页，2026年）DOI: 10.21101/cejph.a9217
Cent Eur J Public Health IF: 00.900Volume 34, Issue 3No.92Epidemiology of ankle fractures: stability and change over two decades踝关节骨折的流行病学：二十年间的稳定性与变化DOI: 10.21101/cejph.a8913
Cleft Palate Craniofac J IF: 01.300Ahead of Print.No.93Witteveen-Kolk Syndrome: Two Patients With Craniofacial Features and Novel SIN3A VariantsWitteveen-Kolk综合征：两例具有颅面特征及新发SIN3A变异的患者DOI: 10.1177/10556656261494180
Curēus IF: 01.300Volume 18, Issue 9No.94Partial Alignment of Electrocardiographic Subspaces Associated With Obesity and Heart Failure in the Third National Health and Nutrition Examination Survey第三次全国健康与营养调查中肥胖与心力衰竭相关心电图子空间的部分对齐DOI: 10.7759/cureus.115932
Frontiers in nutrition IF: 05.100Volume 13, Issue No.95Maternal obesity, diet, and the gut microbiome: implications for offspring cardiometabolic programming母亲肥胖、饮食与肠道微生物组：对子代心血管代谢编程的影响DOI: 10.3389/fnut.2026.1909112
J Orthop Case RepVolume 16, Issue 10No.96A Hand-Palm Technique for Localization of the Greater Trochanter Tip During Proximal Femoral Nailing: A Prospective Pilot Validation Study股骨近端髓内钉术中定位大转子尖的手掌技术：一项前瞻性初步验证研究DOI: 10.13107/jocr.2026.v16.i10.8354
Obesity science & practice IF: 01.900Volume 12, Issue 5No.97Patient Knowledge of GLP-1 Receptor Agonists for Obesity and Exploration of Potential Household-Level Effects in an Urban Health System患者对用于肥胖的GLP-1受体激动剂的认知及在城市卫生系统中对潜在家庭层面效应的探索DOI: 10.1002/osp4.70199
Discover public healthVolume 23, Issue 1No.98Sociodemographic correlates of perceived COVID-19 impact on movement behaviors in Croatian school-aged children克罗地亚学龄儿童感知COVID-19对运动行为影响的社会人口学相关因素DOI: 10.1186/s12982-026-02827-9
Health science reports IF: 02.100Volume 9, Issue 10No.99Dietary Approaches to Stop Hypertension Diet Pattern and Metabolic Syndrome Prevalence Among U.S. Young Adults: Cross-Sectional Study From the NHANES 2011-2018终止高血压膳食模式与美国年轻成人代谢综合征患病率：基于NHANES 2011-2018的横断面研究DOI: 10.1002/hsr2.73194
OTA international :Volume 9, Issue 4No.100Estrogen hormonal therapy is not associated with increased risk of venous thrombosis in total hip arthroplasty or hemiarthroplasty for femoral neck fractures雌激素激素治疗与股骨颈骨折全髋关节置换术或半髋关节置换术后静脉血栓形成风险增加无关DOI: 10.1097/OI9.0000000000000532
Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.101Association between urinary metabolomics and cognitive performance in Asians with type 2 diabetes亚洲2型糖尿病患者尿液代谢组学与认知表现之间的关联DOI: 10.1177/13872877261493174
Int J Low Extrem Wounds IF: 01.500Ahead of Print.No.102Offloading Matters: A Meta-Research Audit of Mechanical Validity in Trials Supporting the 2023 IWGDF Recommendations on Interventions to Enhance Healing of Foot Ulcers in People with DM减压至关重要：对支持2023年IWGDF关于增强糖尿病患者足溃疡愈合干预建议的试验中力学有效性的元研究审计DOI: 10.1177/15347346261493802
Phlebology IF: 01.500Ahead of Print.No.103Mechanochemical ablation versus cyanoacrylate glue closure for treatment of incompetent saphenous veins in C2-C4 patients: Three-year outcomes of a single-centre, single-operator experience机械化学消融与氰基丙烯酸酯胶闭合治疗C2-C4患者功能不全隐静脉的比较：单中心、单术者经验的三年结局DOI: 10.1177/02683555261492365
Diabetes care IF: 16.600Ahead of Print.No.104Continuous Glucose Monitoring Studies Should Not Be Exempt From the Reproducibility Revolution连续血糖监测研究不应被排除在可重复性革命之外DOI: 10.2337/dc26-1932
Glycobiology IF: 03.300Ahead of Print.No.105Milestones in O-GlcNAc Research: Technological Advances that Shaped the FieldO-GlcNAc研究的里程碑：塑造该领域的技术进步DOI: 10.1093/glycob/cwag093
JACC: AdvancesAhead of Print.No.106Preoperative Angiographic Washout and Coronary Artery Bypass Graft Patency术前血管造影对比剂冲刷与冠状动脉旁路移植术桥血管通畅性DOI: 10.1016/j.jacadv.2026.103204
Diabetes IF: 07.500Ahead of Print.No.107A Classification Algorithm for Diabetes Subtypes in a Swedish Cohort: Comparison With National Diabetes Register Diagnoses and Genetic Validation瑞典队列中糖尿病亚型分类算法：与全国糖尿病登记诊断的比较及遗传验证DOI: 10.2337/db26-0524
Journal of global health IF: 04.300Volume 16, Issue No.108Addressing non-communicable diseases and injuries through an equity lens: insights from the Cameroon non-communicable disease and injury (NCDI) Poverty Commission通过公平视角应对非传染性疾病和伤害：来自喀麦隆非传染性疾病和伤害（NCDI）贫困委员会的见解DOI: 10.7189/jogh.16.04266
Transl Vis Sci Technol IF: 02.600Volume 15, Issue 10No.109Erratum in: The Impact of Inflammatory Hyperreflective Spots and Hard Exudates on Retinal Function in Diabetic Retinal Disease勘误：炎症性高反射点及硬性渗出对糖尿病视网膜病变视网膜功能的影响DOI: 10.1167/tvst.15.10.12
Stat Methods Med Res IF: 01.900Ahead of Print.No.110A Bayesian prevalence incidence cure model for estimating survival using electronic health records with incomplete baseline diagnoses利用基线诊断不完整的电子健康记录估计生存率的贝叶斯患病率-发病率-治愈模型DOI: 10.1177/09622802261495109
J Sports Med Phys Fitness IF: 01.300Ahead of Print.No.111The presence of diabetes in chronic kidney disease is associated with lower cardiorespiratory fitness慢性肾脏病合并糖尿病与较低的心肺适能相关DOI: 10.23736/S0022-4707.26.17225-9
Int J Low Extrem Wounds IF: 01.500Ahead of Print.No.112Is "No-Option Critical Limb Threatening Ischaemia" a Right Definition? A Paradigm Shift Driven by Autologous Cell Therapy for Diabetic Foot Disease“无选择危重肢体威胁性缺血”的定义正确吗？自体细胞治疗驱动糖尿病足疾病范式转变DOI: 10.1177/15347346261496150
Chronic Obstr Pulm Dis IF: 02.000Ahead of Print.No.113Randomized Double-Blinded Pilot Study of Doxycycline for HIV-Associated COPD and Emphysema多西环素治疗HIV相关COPD和肺气肿的随机双盲初步研究DOI: 10.15326/jcopdf.2026.0796
Clinical endocrinology IF: 02.400Ahead of Print.No.114Adrenal Infections: An Underrecognized Cause of Primary Adrenal Insufficiency肾上腺感染：原发性肾上腺功能不全的一个未被充分认识的原因DOI: 10.1111/cen.70222
J Diabetes Investig IF: 03.000Ahead of Print.No.115Diabetes attenuates weight reduction-mediated liver fibrosis regression in persons with morbid obesity糖尿病减弱病态肥胖患者减重介导的肝纤维化消退DOI: 10.1111/jdi.70465
Advanced healthcare materials IF: 09.600Ahead of Print.No.116An Antimicrobial, Cell-Adhesive, and Growth Factor-Producing Living Material Engineered From Bacillus subtilis Biofilms for Wound Healing一种由枯草芽孢杆菌生物膜工程化构建的抗菌、细胞黏附及生长因子生成型活材料用于伤口愈合DOI: 10.1002/adhm.71823
Medical journal of Australia IF: 08.500Volume 224, Issue 10No.117Prediabetes: The Looming Burden for Australia糖尿病前期：澳大利亚迫在眉睫的负担DOI: 10.5694/mja2.70284
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.118Autophagy Regulates Foxo1 Protein Abundance to Control Hepatic Glucose Production in Glucagon Signalling自噬通过调节Foxo1蛋白丰度控制胰高血糖素信号中的肝脏葡萄糖生成DOI: 10.1111/dom.71413
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.119Early Testing of a Mobile App-Based Intervention to Support Body Weight Awareness and Monitoring in Pregnancy: A Randomised Controlled Feasibility Trial (BUMP2.0)支持孕期体重意识和监测的移动应用程序干预的早期测试：一项随机对照可行性试验（BUMP2.0）DOI: 10.1111/dom.71426
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.120Polygenic Risk Scores for Islet Autoantibody Positive Early-Stage Type 1 Diabetes Pre-Screening用于胰岛自身抗体阳性早期1型糖尿病预筛查的多基因风险评分DOI: 10.1111/dom.71417
Curēus IF: 01.300Volume 18, Issue 10No.121Retraction: Impact of Microplastic Exposure on Human Health: A Systematic Review of Mechanisms, Biomarkers, and Clinical Outcomes撤稿声明：微塑料暴露对人类健康的影响：机制、生物标志物和临床结局的系统综述DOI: 10.7759/cureus.r251
Tobacco induced diseases IF: 01.900Volume 24, Issue No.122Association between smoking cessation duration and prediabetes among former smokers: A secondary dataset analysis of the Korea National Health and Nutrition Examination Survey 2015-2024戒烟持续时间与糖尿病前期之间的关联：2015-2024年韩国国民健康与营养调查的二次数据集分析DOI: 10.18332/tid/236889
Curēus IF: 01.300Volume 18, Issue 9No.123Clinical, Bacterial, and Antibiogram Profiles of Infections Among Type 2 Diabetes Mellitus Patients in a Tertiary Care Center三级医疗中心2型糖尿病患者感染的临床、细菌及抗菌谱特征分析DOI: 10.7759/cureus.115889
Environ Health Perspect IF: 09.800Volume 134, Issue 6No.124Associations of Urinary Triclosan Concentrations Across Gestation and Childhood with the Adolescent Gut Microbiome妊娠期和儿童期尿液三氯生浓度与青少年肠道微生物组的关联DOI: 10.1021/EHP.6c00017
Journal of the Endocrine Society IF: 03.100Volume 10, Issue 11No.125Longer sleep duration and the incidence and progression of diabetic nephropathy: a prospective cohort study较长的睡眠时间与糖尿病肾病的发生和进展：一项前瞻性队列研究DOI: 10.1210/jendso/bvag201
Rev Panam Salud Publica IF: 02.200Volume 50, Issue No.126HEARTS Accreditation: institutionalizing quality improvement of integrated cardiovascular, kidney, and metabolic services in primary careHEARTS认证：将初级保健中整合型心血管、肾脏和代谢服务的质量改进制度化DOI: 10.26633/RPSP.2026.101
Case reports in pediatrics IF: 00.500Volume 2026, Issue No.127A Case of Misdiagnosed Pediatric Congenital Nephrogenic Diabetes Insipidus due to AQP2 Variants一例因AQP2变异导致误诊的儿童先天性肾性尿崩症DOI: 10.1155/crpe/9068249
Health science reports IF: 02.100Volume 9, Issue 10No.128Do Physicians' Behaviors Matter for Patients With Chronic Diabetes and Hypertension? A Qualitative Descriptive Study of Patients' Lived Experiences in the Bangladeshi Healthcare Landscape医师行为对慢性糖尿病和高血压患者重要吗？一项关于孟加拉国医疗环境中患者生活体验的定性描述性研究DOI: 10.1002/hsr2.73368
World J Otorhinolaryngol Head Neck Surg IF: 01.400Ahead of Print.No.129Treatment Persistence and Factors Associated With Discontinuation in Real-World Biologic Therapy for Chronic Rhinosinusitis With Nasal Polyps真实世界生物制剂治疗慢性鼻窦炎伴鼻息肉的持续用药情况及停药相关因素DOI: 10.1002/wjo2.70183
Am J Lifestyle Med IF: 01.300Ahead of Print.No.130Shared Medical Appointments (SMAs) in Lifestyle Medicine Practice: An Expert Consensus Statement From the American College of Lifestyle Medicine生活方式医学实践中的共享医疗预约：来自美国生活方式医学学院的专家共识声明DOI: 10.1177/15598276261485880
Frontiers in health services IF: 02.700Volume 6, Issue No.131Implementing a multi-centre hypoglycaemia management surveillance model through a co-designed approach to develop actionable insights in the UK通过共同设计方法实施多中心低血糖管理监测模型以在英国产生可操作的见解DOI: 10.3389/frhs.2026.1862035
J Orthop Case RepVolume 16, Issue 10No.132Early Surgical Escalation and Structured Multidisciplinary Pathways Improve Limb-Salvage Outcomes in Necrotizing Fasciitis: A Two-Cycle Quality Improvement Project早期手术升级与结构化多学科路径改善坏死性筋膜炎的保肢结局：一项两周期质量改进项目DOI: 10.13107/jocr.2026.v16.i10.8348
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.133Androgen and glucocorticoid crosstalk in granulosa cells: molecular insights into polyendocrine metabolic ovarian syndrome颗粒细胞中雄激素与糖皮质激素的交互作用：多内分泌代谢性卵巢综合征的分子见解DOI: 10.3389/fendo.2026.1943976
Front Cell Infect Microbiol IF: 04.800Volume 16, Issue No.134Biopsychosocial determinants of tuberculosis care and treatment outcomes: a scoping review and bibliometric analysis结核病诊疗与治疗结局的生物心理社会决定因素：范围综述与文献计量学分析DOI: 10.3389/fcimb.2026.1958725
Diabetes care IF: 16.600Ahead of Print.No.135Effect of Fenofibrate on Progression of Diabetic Retinopathy in People With Type 1 Diabetes: Results From the LENS Trial非诺贝特对1型糖尿病患者糖尿病视网膜病变进展的影响：LENS试验结果DOI: 10.2337/dc26-1470
Chronic Dis Transl MedAhead of Print.No.136Systemic Diseases and the Eye: A Translational Perspective on Diabetes全身性疾病与眼：糖尿病的转化视角DOI: 10.1002/cdt3.70071
Frontiers in digital health IF: 03.800Volume 8, Issue No.137Real-world validation of an AI-based non-mydriatic fundus camera in the diagnosis of diabetic retinopathy in Liberia基于人工智能的非散瞳眼底相机在利比里亚糖尿病视网膜病变诊断中的真实世界验证DOI: 10.3389/fdgth.2026.1938702
Frontiers in systems biologyVolume 6, Issue No.138Latent multimorbidity classes and antithrombotic medication distributions among patients hospitalized for bleeding after dental surgery: a retrospective study牙科手术后出血住院患者的潜在多病共存类别与抗血栓药物分布：一项回顾性研究DOI: 10.3389/fsysb.2026.1917159
Journal of animal science IF: 02.900Ahead of Print.No.139Alterations in the liver phosphoproteome of finishing cattle with divergent dry matter intake不同干物质采食量的育肥牛肝脏磷酸化蛋白质组的变化DOI: 10.1093/jas/skag325
Curr Protein Pept Sci IF: 02.000Ahead of Print.No.140Comparative Evaluation of Surfactants and Stabilizers in Preventing Protein Aggregation in Insulin Formulations表面活性剂与稳定剂在预防胰岛素制剂中蛋白质聚集的比较评价DOI: 10.2174/0113892037484972260921041034
Current pediatric reviews IF: 01.600Ahead of Print.No.141Pediatric MASLD Evolution: A Distinct Entity from Adult Disease in Pathophysiology, Diagnosis, and Non-invasive Evaluation儿童脂肪性肝病的演变：在病理生理学、诊断和无创评估方面与成人疾病不同的独特实体DOI: 10.2174/0115733963493273260928074302
Current pharmaceutical design IF: 02.800Ahead of Print.No.142Phytochemical Composition, Pharmacological Activities, and Clinical Evidence of Bacopa monnieri in Cognitive and Memory EnhancementBacopa monnieri在认知与记忆增强中的植物化学成分、药理活性及临床证据DOI: 10.2174/0113816128496771260919124515
Can J Hosp Pharm IF: 00.600Volume 79, Issue 4No.143Nurses' Perceptions, Attitudes, and Recommendations Concerning Medication Waste in Health Care Facilities: A Survey of Lower Mainland Nurses护士对医疗机构药物浪费的认知、态度和建议：对Lower Mainland护士的调查DOI: 10.4212/cjhp.3938
Case reports in endocrinology IF: 00.900Volume 2026, Issue No.144Persistent Hyperinsulinemic Hypoglycemia After Insulinoma Surgery: Diagnostic Impact of GLP-1 Receptor PET/CT After Negative Conventional Imaging胰岛素瘤术后持续性高胰岛素性低血糖：常规影像阴性后GLP-1受体PET/CT的诊断价值DOI: 10.1155/crie/7874466
Environ Health Perspect IF: 09.800Volume 134, Issue 6No.145Untargeted Lipidomics Analysis of Prenatal Per- and Polyfluoroalkyl Substances (PFAS) Exposure and Small-for-Gestational Age (SGA) Delivery: An Exploratory Study in the Atlanta African American Maternal-Child Cohort, 2014-2020产前全氟和多氟烷基物质暴露与小于胎龄儿分娩的非靶向脂质组学分析：亚特兰大非裔美国人母婴队列2014-2020年探索性研究DOI: 10.1021/EHP.6c00018
Iran J Vet ResVolume 27, Issue 1No.146Hormonal, biochemical and hematological changes in neonatal calves with sepsis induced by enteritis肠炎诱导的新生犊牛脓毒症中的激素、生化和血液学变化DOI: 10.22099/ijvr.2025.52264.7798
Frontiers in public health IF: 03.400Volume 14, Issue No.147Artificial intelligence-driven therapeutics for disease modification in type 1 diabetes: a digital public health and clinical translation framework人工智能驱动的1型糖尿病疾病修饰治疗：数字公共卫生与临床转化框架DOI: 10.3389/fpubh.2026.1915502
RSC advances IF: 04.600Ahead of Print.No.148Retardation of human insulin amyloid fibrillation by vitamin B1维生素B1延缓人胰岛素淀粉样纤维化DOI: 10.1039/d6ra06247d
FCVM IF: 02.900Volume 13, Issue No.149SCAPIS 2 spectrum: rationale, objectives and design of a microvascular dysfunction sub-study within the Swedish CArdioPulmonary bioImage studySCAPIS 2 Spectrum：瑞典心肺生物影像研究中的微血管功能障碍亚研究的基本原理、目标与设计DOI: 10.3389/fcvm.2026.1899591
ACS omega IF: 04.300Volume 11, Issue 39No.150Discovery of Novel Peptides as DPP-IV Inhibitors: In Silico Screening, Molecular Dynamics Simulations, and Preliminary In Vitro Evaluation新型肽类二肽基肽酶-IV抑制剂的发现：计算机筛选、分子动力学模拟及初步体外评价DOI: 10.1021/acsomega.6c08022
JACC: Case reportsAhead of Print.No.151Durable Vessel Patency Achieved by Drug-Coated Balloon-Only Percutaneous Coronary Intervention in Triglyceride Deposit Cardiomyovasculopathy药物涂层球囊单纯经皮冠状动脉介入治疗在甘油三酯沉积性心肌血管病中实现持久血管通畅DOI: 10.1016/j.jaccas.2026.110636
Journal of Hypertension IF: 04.100Ahead of Print.No.152Acute mental stress-induced adrenergic reactivity profiles predict distinct cardiometabolic risk trajectories over three years: the SABPA study急性精神压力诱导的肾上腺素能反应特征预测三年内不同的心血管代谢风险轨迹：SABPA研究DOI: 10.1097/HJH.0000000000004454
Sleep IF: 04.900Ahead of Print.No.153Prediction of cardiovascular outcomes using electrocardiography from overnight polysomnography利用夜间多导睡眠监测中的心电图预测心血管结局DOI: 10.1093/sleep/zsag229
Frontiers in strokeVolume 5, Issue No.154Sex differences in risk factors, stroke etiology, treatment characteristics, and outcomes after endovascular treatment for anterior circulation ischemic stroke前循环缺血性卒中血管内治疗后在危险因素、卒中病因、治疗特征及结局方面的性别差异DOI: 10.3389/fstro.2026.1946990
Case Reports in Cardiology IF: 00.500Volume 2026, Issue No.155Stentless Management of Cannabis-Associated STEMI in Young Adults: Two Case Reports年轻成人大麻相关ST段抬高型心肌梗死的无支架管理：两例病例报告DOI: 10.1155/cric/2378215
J Orthop Case RepVolume 16, Issue 10No.156Total Hip Arthroplasty for Neglected Pathological Femoral Neck Fracture in a Young Patient with Autoimmune Polyglandular Syndrome年轻自身免疫性多腺体综合征患者忽视性病理性股骨颈骨折的全髋关节置换术DOI: 10.13107/jocr.2026.v16.i10.8288
Mini Rev Med Chem IF: 03.300Ahead of Print.No.157Exploring Isatin Derivatives as Multifunctional Antidiabetic Agents: Insights into α-Glucosidase and α-Amylase Inhibition探索靛红衍生物作为多功能抗糖尿病药物：对α-葡萄糖苷酶和α-淀粉酶抑制作用的见解DOI: 10.2174/0113895575483401260915070007
J Emerg Trauma Shock IF: 01.200Volume 19, Issue 3No.158Increased Allergy Susceptibility Associated with Semaglutide, a Glucagon-like Peptide-1 Receptor Agonist司美格鲁肽（一种胰高血糖素样肽-1受体激动剂）与过敏易感性增加相关DOI: 10.4103/jets.jets_188_25
Health affairs scholarVolume 4, Issue 10No.159Sociodemographic disparities in semaglutide and tirzepatide prescription for obesity treatment司美格鲁肽与替尔泊肽用于肥胖治疗的处方存在社会人口学差异DOI: 10.1093/haschl/qxag255
microPublication biologyVolume 2026, Issue No.160Semaglutide Reduces Odorant-Driven Chemotaxis and Reproductive Output in Caenorhabditis elegans司美格鲁肽减少秀丽隐杆线虫气味驱动的趋化性和生殖输出DOI: 10.17912/micropub.biology.002168
Clin Pharmacol Ther IF: 05.500Ahead of Print.No.161Obstetric Pharmacomicrobiomics产科药物微生物组学DOI: 10.1002/cpt.70520
Allergologie select IF: 06.000Volume 10, Issue No.162In-hospital sting challenge during venom immunotherapy has a high negative predictive value for subsequent sting reactions毒液免疫治疗期间的院内蜂刺激发试验对后续蜂刺反应具有高阴性预测价值DOI: 10.5414/ALX02652E
Journal of food science IF: 03.400Volume 91, Issue 10No.163Phyto-Metabolomic Insights Into Ficus hispida Linn.: Antioxidant Activity, Polyphenolic Content, and Antidiabetic Marker Discovery via LC-ESI-Orbitrap-MS/MS and GC-QqQ-MS/MSFicus hispida Linn.的植物代谢组学见解：通过LC-ESI-Orbitrap-MS/MS和GC-QqQ-MS/MS发现抗氧化活性、多酚含量和抗糖尿病标志物DOI: 10.1111/1750-3841.71518
Can J Physiol Pharmacol IF: 01.300Volume 104, Issue No.164Incretins in Action: Unlocking New Frontiers from Bench to Bedside肠促胰岛素在行动：解锁从实验室到临床的新前沿DOI: 10.1139/cjpp-2026-0110
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.165Beyond efficacy: the treatment lifecycle of incretin and multi-receptor agonists超越有效性：肠促胰素与多受体激动剂的治疗生命周期DOI: 10.3389/fendo.2026.1902185
Mov Disord Clin Pract IF: 02.700Ahead of Print.No.166Pregabalin in Dopamine Dysregulation Syndrome普瑞巴林在多巴胺失调综合征中的应用DOI: 10.1002/mdc3.70818
Journal of Endovascular Therapy IF: 01.500Ahead of Print.No.167Heart Failure Predicts Contralateral Limb Progression After Endovascular Therapy for Initial Unilateral Chronic Limb-Threatening Ischemia心力衰竭预测初始单侧慢性肢体威胁性缺血血管内治疗后的对侧肢体进展DOI: 10.1177/15266028261495914
BMJ medicine IF: 10.000Volume 5, Issue 1No.168Pregnancy complications and risk of cardiometabolic-renal conditions in 1.4 million women in England: longitudinal study妊娠并发症与140万英格兰女性心血管代谢肾脏疾病风险：纵向研究DOI: 10.1136/bmjmed-2026-003035
Frontiers in pain research IF: 02.700Volume 7, Issue No.169Metabolic and neuropathic outcomes following combined sodium-glucose cotransporter-2 inhibitor therapy and adjunctive acupuncture in obese patients with diabetic neuropathy: a case series钠-葡萄糖共转运蛋白2抑制剂联合辅助针灸治疗肥胖糖尿病神经病变患者的代谢与神经病变结局：病例系列DOI: 10.3389/fpain.2026.1886313
Hypertension Research IF: 04.600Ahead of Print.No.170Hypertension: a missing piece in HFpEF?高血压：射血分数保留的心力衰竭中缺失的一环？DOI: 10.1038/s41440-026-02855-7
Cochrane Database Syst Rev IF: 09.400Volume 10, Issue 10No.171Pharmaceutical industry information and promotional strategies aimed at prescribers针对处方者的制药行业信息与推广策略DOI: 10.1002/14651858.CD013423.pub3
Indian J Med Res IF: 02.500Volume 164, Issue 4No.172Obesity-related bone fragility: An emerging clinical paradox肥胖相关骨脆性：一个新兴的临床悖论DOI: 10.25259/IJMR_3268_2026
Hand IF: 01.800Ahead of Print.No.173Does Body Mass Index Influence Time to Surgery After Diagnosis of Carpal Tunnel Syndrome?体重指数是否影响腕管综合征诊断后至手术的时间？DOI: 10.1177/15589447261489856
Birth IF: 02.500Ahead of Print.No.174Maternal Circadian Preference is Associated With Cardiorespiratory Fitness and Participation in Structured Prenatal Exercise母亲昼夜节律偏好与心肺适能及结构化产前运动参与相关DOI: 10.1111/birt.70130
Obesity reviews IF: 07.400Ahead of Print.No.175Integrated Obesity Management for Children and Adolescents for Improved Health: A Special Issue儿童和青少年综合肥胖管理以改善健康：特刊DOI: 10.1111/obr.70244
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz IF: 01.500Ahead of Print.No.176[Promoting participation in sports clubs: sports- and physical activity-oriented social work with people with disabilities]促进体育俱乐部参与：面向残疾人的体育与体力活动导向社会工作DOI: 10.1007/s00103-026-04317-4
International journal of obesity IF: 03.800Ahead of Print.No.177Eating speed in complementary fed infants: associations with energy intake, weight status, breastfeeding, baby food pouch use and baby-led weaning辅食喂养婴儿的进食速度：与能量摄入、体重状态、母乳喂养、婴儿食品袋使用及婴儿主导断奶的关联DOI: 10.1038/s41366-026-02234-9
European journal of pediatrics IF: 02.600Volume 185, Issue 11No.178Vitamin D status and adiposity in children with low-energy fractures: a prospective case-control study低能量骨折儿童的维生素D状态与肥胖：一项前瞻性病例对照研究DOI: 10.1007/s00431-026-07509-x
Frontiers in ophthalmologyVolume 6, Issue No.179Comparative analysis of cataract surgery outcomes in elderly Jewish and Arab patients from Northern Israel, a retrospective cohort study以色列北部犹太与阿拉伯老年患者白内障手术结局的比较分析：一项回顾性队列研究DOI: 10.3389/fopht.2026.1942047
Frontiers in ophthalmologyVolume 6, Issue No.180Screening of natural compounds library for protection against endoplasmic reticulum stress in corneal endothelial cells天然化合物库筛选保护角膜内皮细胞内质网应激的化合物DOI: 10.3389/fopht.2026.1945775
Indian J Med Res IF: 02.500Volume 164, Issue 4No.181Exploring gender-related patterns in diabetic peripheral neuropathy: Limitations of current evidence探索糖尿病周围神经病变中的性别相关模式：当前证据的局限性DOI: 10.25259/IJMR_575_2026
Indian J Med Res IF: 02.500Volume 164, Issue 4No.182Prevalence, risk-factors and early prediction of impaired kidney function among indigenous adults in Odisha, India: A secondary analysis印度奥里萨邦原住民成年人肾功能受损的患病率、风险因素及早期预测：一项二次分析DOI: 10.25259/IJMR_491_2026
Emergency medicine Australasia IF: 01.400Volume 38, Issue 5No.183A Retrospective Descriptive Analysis of Consultations Provided by the National Poisons Centre Relating to Medicines on the Aotearoa New Zealand Antidote Stocking Guideline, 2020-20252020-2025年Aotearoa New Zealand国家毒物中心关于解毒剂储备指南中药物的咨询回顾性描述分析DOI: 10.1111/1742-6723.70366
The plant genome IF: 03.800Volume 19, Issue 4No.184Feasibility and pitfalls of combining small subpopulations for genome-wide association analysis of maize (Zea mays L.) kernel traits整合小亚群进行玉米籽粒性状全基因组关联分析的可行性与陷阱DOI: 10.1002/tpg2.70319
Clinical autonomic research IF: 03.400Ahead of Print.No.185Insulin resistance is potentially associated with 24-h blood pressure variability related to blunted sympathetic reactivity in older adults with hypertension胰岛素抵抗可能与老年高血压患者交感反应减弱相关的24小时血压变异性有关DOI: 10.1007/s10286-026-01241-0
Naunyn Schmiedebergs Arch Pharmacol IF: 03.100Ahead of Print.No.186The impact of paroxetine on insulin secretion and sensitivity through AKT/GLUT4 axis帕罗西汀通过AKT/GLUT4轴对胰岛素分泌和敏感性的影响DOI: 10.1007/s00210-026-05966-7
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.187Anti-Müllerian hormone in relation to adiposity and metabolic indices in polyendocrine metabolic ovarian syndrome抗苗勒管激素与多内分泌代谢性卵巢综合征中肥胖及代谢指标的关系DOI: 10.3389/fendo.2026.1975667
Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 6No.188Comparison of Clinical, Metabolic, and Hormonal Profiles in Obese Versus Lean Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis肥胖与瘦型多囊卵巢综合征女性临床、代谢及激素特征的比较：系统综述与荟萃分析DOI: 10.1002/edm2.70350
BMC endocrine disorders IF: 03.300Volume 26, Issue 1No.189Serum melatonin levels and their relationship with inflammation and oxidative stress in patients with diabetic nephropathy: a cross-sectional case-control study糖尿病肾病患者血清褪黑素水平及其与炎症和氧化应激的关系：一项横断面病例对照研究DOI: 10.1186/s12902-026-02634-y
Handb Exp PharmacolAhead of Print.No.190Repurposing SGLT2 Inhibitors Beyond Diabetes: Emerging Roles in Cancer Prevention and TherapySGLT2抑制剂在糖尿病之外的新用途：在癌症预防和治疗中的新兴作用DOI: 10.1007/164_2026_846
Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 6No.191Diabetic Autonomic Neuropathy and Impaired Inflammatory Reflex糖尿病自主神经病变与受损的炎症反射DOI: 10.1002/edm2.70349
J Cachexia Sarcopenia Muscle IF: 09.100Volume 17, Issue 5No.192Age- and Sex-Specific Percentile Curves for the FM/FFM Ratio Using Data From the Canadian Longitudinal Study on Aging基于加拿大老龄化纵向研究数据的年龄和性别特异性脂肪质量与瘦体重比值百分位曲线DOI: 10.1002/jcsm.70399
Journal of diabetes IF: 03.700Volume 18, Issue 10No.193Diabetes Medication Market: Costs and Utilization of Glucagon-Like Peptide 1 (GLP-1) Prescriptions From 2008 to 2023糖尿病药物市场：2008年至2023年胰高血糖素样肽1（GLP-1）处方的成本与利用DOI: 10.1111/1753-0407.70278
Indian J Med Res IF: 02.500Volume 164, Issue 4No.194Authors' Response作者回应DOI: 10.25259/IJMR_3071_2026
Rural and remote health IF: 02.500Volume 26, Issue 4No.195The utility of point-of-care haemoglobin A1c tests in a very remote Aboriginal and Torres Strait Islander community: an agreement analysis with routine laboratory testing即时糖化血红蛋白检测在极偏远原住民和托雷斯海峡岛民社区中的效用：与常规实验室检测的一致性分析DOI: 10.22605/RRH10969
Surgical endoscopy IF: 02.700Ahead of Print.No.196The impact of semaglutide initiated six months after laparoscopic sleeve gastrectomy on long-term weight loss and metabolic outcomes: single-center preliminary study腹腔镜袖状胃切除术后六个月启动司美格鲁肽对长期减重及代谢结局的影响：单中心初步研究DOI: 10.1007/s00464-026-13505-x
Brain and behavior IF: 02.700Volume 16, Issue 10No.197Impact of Modifiable Cardiovascular Risk Factors and Protective Therapies on Hemorrhagic Events in Cerebral Cavernous Malformations: A Systematic Review and Meta-Analysis可改变的心血管危险因素与保护性治疗对脑海绵状血管畸形出血事件的影响：系统综述与荟萃分析DOI: 10.1002/brb3.71829
Journal of internal medicine IF: 09.200Ahead of Print.No.198GLP-1 receptor agonists and serious adverse events: Evidence, uncertainty and clinical implicationsGLP-1受体激动剂与严重不良事件：证据、不确定性与临床意义DOI: 10.1111/joim.70170
BMC ophthalmology IF: 01.700Volume 26, Issue 1No.199Trigeminal sensory neuropathy developing as a late complication after the treatment of surgically induced necrotizing scleritis following pterygium surgery: a case report and literature review翼状胬肉手术后手术诱导的坏死性巩膜炎治疗后期并发三叉神经感觉神经病：病例报告及文献综述DOI: 10.1186/s12886-026-05408-1
Clinical obesity IF: 02.100Volume 16, Issue 6No.200Weight-Loss Outcomes After Sleeve Gastrectomy Versus Tirzepatide in a Minority Cohort With Severe Obesity: Results From a Propensity Score Matched Cohort袖状胃切除术与替尔泊肽在重度肥胖少数族裔队列中的减重结局：倾向性评分匹配队列研究结果DOI: 10.1111/cob.70116
204
Diabetes Mellitus(DM)
糖尿病
82
Obesity
肥胖症
51
Insulin
胰岛素
29
Type 2 diabetes mellitus(T2DM)
2型糖尿病
17
Diabetic Retinopathy
糖尿病视网膜病
10
Hypoglycemic Agents
降糖药
10
Semaglutide
司美格鲁肽
9
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
9
Metabolic Syndrome
代谢综合征
9
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
7
Tirzepatide
替尔泊肽
6
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
5
Metformin
二甲双胍
4
Diabetic Foot
糖尿病足
4
gamma-Aminobutyric Acid(GABA)
γ-氨基丁酸
4
Gabapentin
加巴喷丁
3
Diabetic Peripheral Neuropathy(PDN)
糖尿病周围神经病变
3
Dapagliflozin
达格列净
3
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
3
Type 1 diabetes mellitus(T1DM)
1型糖尿病
2
Liraglutide
利拉鲁肽
2
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
2
Diabetes mellitus in pregnancy
妊娠期糖尿病
2
Diabetes Complications
糖尿病并发症
2
Diabetic Neuropathies
糖尿病性神经病变
2
Pregabalin
普瑞巴林
1
Diabetic acidosis
糖尿病性酸中毒
1
Diabetic Cardiomyopathies
糖尿病心肌病
1
Empagliflozin
恩格列净
1
Gastrointestinal lipase inhibitor
胃肠道脂肪酶抑制剂
1
Orlistat
奥利司他
1
Canagliflozin
卡格列净
1
Exenatide
艾塞那肽
编辑：韩玉莲
审校：韩玉莲
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 经前焦虑症 | 美国 | 2003-08-28 | |
| 恐慌 | 日本 | 2000-09-22 | |
| 焦虑症 | 巴西 | 1999-12-22 | |
| 广泛性焦虑障碍 | 美国 | 1997-06-25 | |
| 创伤后应激障碍 | 美国 | 1997-06-25 | |
| 抑郁症 | 中国 | 1995-01-01 | |
| 重度抑郁症 | 美国 | 1992-12-29 | |
| 强迫症 | 美国 | 1992-12-29 | |
| 惊恐障碍 | 美国 | 1992-12-29 | |
| 社交恐怖症 | 美国 | 1992-12-29 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 听力损失 | 临床2期 | 英国 | 2006-09-21 | |
| 耳鸣 | 临床2期 | 英国 | 2006-09-21 | |
| 帕金森病 | 临床2期 | 美国 | 2003-06-01 | |
| 难治性抑郁症 | 临床阶段不明 | 美国 | 2003-12-01 | |
| 肿瘤 | 临床前 | 中国 | 2026-01-27 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
N/A | - | 443 | 淵醖廠憲遞獵鹽蓋壓顧(鹹壓窪餘遞憲鏇淵襯鹹) = 繭蓋壓鹹簾鬱獵憲鏇鏇 窪鏇獵築遞獵醖製鬱夢 (遞繭餘網觸鬱觸觸鏇廠 ) 更多 | 积极 | 2026-05-02 | ||
临床4期 | 78 | (Nortriptyline + Topiramate) | 鏇鏇壓糧顧鏇齋製壓觸(遞鏇夢餘鏇糧衊蓋鏇觸) = 蓋網鏇範襯齋觸窪衊獵 網遞鬱繭醖願餘艱觸顧 (積糧鑰齋憲簾艱膚艱鹽, 鬱蓋築衊糧繭範簾艱夢 ~ 鬱繭鏇觸遞襯艱製淵窪) 更多 | - | 2026-04-16 | ||
(Verapamil + Paroxetine) | 鏇鏇壓糧顧鏇齋製壓觸(遞鏇夢餘鏇糧衊蓋鏇觸) = 淵鑰夢鹽願艱獵鹽簾獵 網遞鬱繭醖願餘艱觸顧 (積糧鑰齋憲簾艱膚艱鹽, 齋繭衊構簾鹽鹽襯鑰遞 ~ 鑰鏇鏇壓選齋鑰鏇觸壓) 更多 | ||||||
临床4期 | 100 | Paroxetine + csDMARDs | 憲蓋範壓繭艱衊憲遞夢(網繭糧夢遞築廠願膚願): P-Value = 0.005 更多 | 积极 | 2025-12-01 | ||
csDMARDs + Placebo | |||||||
临床1期 | 27 | Placebo+Oxycodone (Treatment A: Placebo) | 鑰壓艱簾糧壓鹹獵鹽蓋(襯淵襯遞鹽選夢願鹹繭) = 餘蓋窪製顧糧簾餘鏇憲 範範齋觸壓網網鑰範鹽 (顧獵積襯簾憲範鏇觸壓, 廠衊築獵窪範築艱製築 ~ 齋膚遞構糧淵願廠衊鑰) 更多 | - | 2025-05-22 | ||
(Treatment B: Paroxetine) | 鑰壓艱簾糧壓鹹獵鹽蓋(襯淵襯遞鹽選夢願鹹繭) = 齋鏇壓簾製願築鏇艱餘 範範齋觸壓網網鑰範鹽 (顧獵積襯簾憲範鏇觸壓, 醖範齋鏇醖繭醖鹹製夢 ~ 夢夢膚鑰膚製糧廠窪鹽) 更多 | ||||||
临床1期 | - | 18 | 壓襯鏇構鏇願艱築膚衊(網夢選鏇鹹願艱積鏇網) = 獵糧壓廠顧製獵醖壓衊 膚衊鬱鑰願積醖選簾艱 (襯鑰夢齋壓餘糧衊鹹淵 ) 更多 | 积极 | 2025-02-28 | ||
壓襯鏇構鏇願艱築膚衊(網夢選鏇鹹願艱積鏇網) = 鑰顧積鬱築願遞壓鏇顧 膚衊鬱鑰願積醖選簾艱 (襯鑰夢齋壓餘糧衊鹹淵 ) 更多 | |||||||
临床1期 | 38 | (Participants Who Received Paroxetine 20 mg) | 糧鹽網齋蓋鏇齋獵蓋鏇(憲顧鹹糧網夢襯製蓋廠) = 遞願夢網鑰廠鏇艱鑰糧 願蓋鬱遞壓膚衊鬱鬱襯 (觸襯觸網範繭遞憲窪壓, 7.37) 更多 | - | 2024-12-16 | ||
(Participants Who Received Paroxetine 40 mg) | 糧鹽網齋蓋鏇齋獵蓋鏇(憲顧鹹糧網夢襯製蓋廠) = 鏇蓋觸顧壓願壓窪餘鑰 願蓋鬱遞壓膚衊鬱鬱襯 (觸襯觸網範繭遞憲窪壓, 10.82) 更多 | ||||||
N/A | 97 | 膚願廠蓋顧窪艱糧壓膚(膚獵糧遞餘壓衊糧獵遞) = 網選鹽鏇窪網襯積糧選 鹽膚憲鏇淵襯遞鑰艱願 (醖鑰壓醖鏇艱蓋簾鏇蓋 ) 更多 | 积极 | 2023-07-04 | |||
Placebo | 膚願廠蓋顧窪艱糧壓膚(膚獵糧遞餘壓衊糧獵遞) = 範顧淵選衊齋憲襯鏇廠 鹽膚憲鏇淵襯遞鑰艱願 (醖鑰壓醖鏇艱蓋簾鏇蓋 ) 更多 | ||||||
临床1期 | 38 | (Paroxetine 20 mg (Test A)) | 餘淵餘繭壓醖艱構餘窪(鏇顧蓋蓋鑰選繭餘鑰壓) = 選鏇壓廠鹹醖鹽蓋製壓 餘鹽壓醖壓鹽膚積憲簾 (範製憲衊積膚鹽餘範蓋, 5.872) 更多 | - | 2022-01-20 | ||
(Paroxetine 20 mg (Reference B)) | 餘淵餘繭壓醖艱構餘窪(鏇顧蓋蓋鑰選繭餘鑰壓) = 餘鹽衊蓋憲廠鹽願願窪 餘鹽壓醖壓鹽膚積憲簾 (範製憲衊積膚鹽餘範蓋, 6.554) 更多 | ||||||
临床2期 | - | 窪襯鏇襯構齋醖壓餘築(製襯鬱選顧鏇鏇鹹壓醖) = 憲鹹淵廠遞襯膚蓋觸積 遞鏇淵觸壓蓋壓淵鏇鬱 (範醖築艱醖鬱窪獵衊膚 ) | 不佳 | 2021-10-01 | |||
Placebo | 窪襯鏇襯構齋醖壓餘築(製襯鬱選顧鏇鏇鹹壓醖) = 構鏇齋鹽積淵簾選範獵 遞鏇淵觸壓蓋壓淵鏇鬱 (範醖築艱醖鬱窪獵衊膚 ) | ||||||
N/A | - | 壓蓋糧蓋繭淵壓淵築艱(願醖餘窪鹽艱鹹窪淵壓) = 廠淵齋鏇選製遞鬱壓衊 積觸製構醖積製襯壓遞 (範鏇衊憲繭獵衊壓憲醖 ) | - | 2018-10-01 | |||
Flupenthixol melitracen | 壓蓋糧蓋繭淵壓淵築艱(願醖餘窪鹽艱鹹窪淵壓) = 鹽餘選艱願觸餘壓構鹽 積觸製構醖積製襯壓遞 (範鏇衊憲繭獵衊壓憲醖 ) |
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