CVN293 was generally well-tolerated in healthy volunteers for up to 14-days of continuous dosing Dose-dependent exposure was observed with evidence of robust brain penetration Data supports potential advancement into Phase 2 for neurodegenerative diseases characterized by neuroinflammation such as Frontotemporal Dementia, Amyotrophic Lateral Sclerosis, and Alzheimer’s Disease Nov. 11, 2024 -- Cerevance, a clinical-stage biopharmaceutical company advancing multiple cell type-specific therapies f

Combination of vilastobart and atezolizumab demonstrated encouraging early evidence of anti-tumor activity, including unconfirmed partial responses observed in two patients with difficult-to-treat, immunologically “cold” tumors Complete resolution of a metastatic liver lesion observed in a patient with microsatellite stable colorectal cancer (MSS CRC) Safety data indicated combination of vilastobart and atezolizumab was generally well-tolerated and support the potential of vilastobart to be a di

Kalaris is a clinical-stage biopharmaceutical company founded by Samsara BioCapital and focused on development of TH103, a novel, differentiated and potentially transformative therapy for patients with neovascular and exudative retinal diseases Invented by VEGF pioneer Dr. Napoleone Ferrara, TH103 has demonstrated longer-acting and increased anti-VEGF activity in head-to-head preclinical studies against aflibercept, and could potentially provide a meaningful advance in treatment in the global $1

AM003 is a first-in-class functional oligonucleotide in development for the treatment of solid tumors First –in-human, monotherapy dose-escalation Phase 1 trial has been successfully completed The study met its primary endpoint of safety and tolerability Nov. 07, 2024 -- Aummune, a clinical –stage biopharmaceutical company developing a unique class of oligonucleotide drugs to treat solid tumors, announced today the completion of a Phase 1 trial of its proprietary investigational product AM003,

Objective response rate (ORR) of 46%, 12-month overall survival (OS) of 91.3% and a median overall survival (mOS) of 21.8 months in first line (1L) HPV+ R/M HNSCC patients treated with CUE-101 and KEYTRUDA® (pembrolizumab) ORR of 50% in 1L patients treated with CUE-101 and pembrolizumab with low PD-L1 expression (combined positive score (CPS) 1-19) 67% overall disease control rate (DCR) in late-stage pancreatic cancer patients treated with CUE-102 monotherapy, including an unconfirmed partial re

近日，海昶生物全资子公司The WhiteOak Group, Inc.（WGI）与浙江大学联合申报的项目《基于CpG-LNPs融合体系的高效安全RSV mRNA疫苗设计的研究》成功获得“2024年度国家自然科学基金委员会与比尔及梅琳达·盖茨基金会全球健康合作研究项目”资助。 该项目旨在解决目前RSV疫苗在细胞免疫不足以及体液免疫Th1/Th2失衡方面的关键问题。研究团队将采用创新的QTsomeTM核酸递送平台技术，将CpG、mRNA与LNPs相融合，使其具有pH响应和淋巴结靶向的特性，从而构建全新的高效RSV mRNA疫苗。这一研究有望为佐剂与递送载体的整合设计提供新的思路，并为开发能够显著激活细胞免疫并产生Th1免疫优势应答的新一代mRNA疫苗奠定基础。 在全球健康合作研究项目中，WGI与浙江大学围绕LNP（脂质体纳米颗粒）佐剂技术在RSV（呼吸道合胞病毒）mRNA疫苗中的应用展现了显著的互补性。WGI与浙江大学将在佐剂和RSV mRNA序列的设计与评价、高效递送系统的设计、表征、工艺开发、免疫机制的研究等方面进行深入探索。此次合作项目成功获得资助，不仅是对公司研发实力的认可，

2024年11月，杭州畅溪制药有限公司（简称“畅溪制药”）宣布与石家庄以岭药业股份有限公司（简称“以岭药业”）就肺部及相关疾病治疗领域的创新药研发达成战略合作。 畅溪制药将利用自身在吸入粉雾剂开发领域的经验和技术，支持以岭药业一系列潜在创新药物分子的开发，双方将充分发挥各自的优势，确保合作产品的市场成功。 目前，在吸入粉雾剂开发领域，粉碎混合技术相对比较成熟、普遍应用于高活性小分子药物的递送。 然而，随着科学技术的飞速发展，创新的小分子活性成分，以及包括mRNA、抗体、噬菌体、小核酸等在内的新形态活性成分逐渐成为主流；也逐渐将新的递送技术从幕后推到台前。 畅溪制药对喷雾干燥技术的应用和积累，为这类药物安全有效地实现肺部精准递送，开辟了新的可能，从而给双方带来了巨大的机会 呼吸系统疾病是我们未来重点关注的领域之一。我们非常欣赏畅溪制药在吸入药物这个细分赛道上的专业实力和创新能力，尤其是可迅速实现工业化生产的喷雾干燥制剂工艺技术，以及与其相匹配的吸入器的设计、开发和评价平台。此次合作标志着双方在这一领域深度合作的开始，我们相信，通过双方的共同努力，我们将为提高患者生活质量带来更多

Nov. 08, 2024 -- Akari Therapeutics, Plc (Nasdaq: AKTX), an innovative biotechnology company developing advanced therapies for autoimmune and inflammatory diseases, announces shareholder approval in connection with the merger of Akari Therapeutics, Plc (the Company) and Peak Bio, Inc. At a General Meeting held in relation to the merger at 9:00 a.m. Eastern Time on Thursday, November 7, 2024 at the Company’s offices in London, shareholders approved the Company’s issuance of shares in connection

Novel H2CasMab-2 Antigen Binding Domain Shown to Preferentially Target HER2 Expressed on Tumor Cells in Preclinical Studies Initial Low-Dose Cohort of FT825 / ONO-8250 as Monotherapy Shows Favorable Safety Profile in Phase 1 Solid Tumor Study Peripheral Blood from First Three Patients Demonstrates CAR T-cell Expansion with Maintenance of Activated State at Day 8 Following Treatment Nov. 09, 2024 -- Fate Therapeutics, Inc. (NASDAQ: FATE), a clinical-stage biopharmaceutical company dedicated to b

Data presented in an oral session at the Society for Immunotherapy of Cancer 39th Annual Meeting, where it was selected as a top 100 abstract Nov. 09, 2024 -- Corvus Pharmaceuticals, Inc. (NASDAQ: CRVS), a clinical-stage biopharmaceutical company, today announced new data highlighting the potential of ciforadenant, the Company’s adenosine A2A receptor antagonist, to overcome resistance to anti-PD1 immunotherapy in the treatment of metastatic castration resistant prostate cancer (mCRPC). The d