预约演示
更新于：2026-06-01
Gemcitabine
吉西他滨
更新于：2026-06-01
概要
基本信息
原研机构 |
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期- |
最高研发阶段(中国)无进展 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C9H11F2N3O4 |
InChIKeySDUQYLNIPVEERB-QPPQHZFASA-N |
CAS号95058-81-4 |
关联
800
项与 吉西他滨 相关的临床试验NCT05700448
A Phase III, Randomized, Double-Blind, Multicenter Study of Sugemalimab (CS1001) Plus PGemOx Regimen Versus Placebo Plus PGemOx for Subjects With Relapsed or Refractory Extranodal NK/T-Cell Lymphoma (R/R ENKTL)
The purpose of this study is to evaluate the efficacy and safety of sugemalimab (CS1001) in combination with PGemOx regimen (pegaspargase, gemcitabine, oxaliplatin) in treatment of adult patients with Extranodal NK/T-Cell Lymphoma (ENKTL) who have relapsed or become refractory to asparaginase-based regimens.
开始日期2027-06-01 |
申办/合作机构 |
NCT07477418
PDAC Regression and Intraoperative Surgical Margin With Neoadjuvant TAMP (PRISM-TAMP): A Phase Ib/II Open-Label Trial
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor survival outcomes, even when treated with modern chemotherapy and radiation. Patients with borderline resectable PDAC often receive neoadjuvant systemic therapy to improve the likelihood of successful surgical removal of the tumor, but rates of incomplete tumor regression and positive surgical margins remain high.
This Phase Ib/II, single-arm study evaluates the safety and feasibility of adding trans-arterial microperfusion (TAMP) delivery of gemcitabine to standard neoadjuvant therapy for patients with borderline resectable PDAC. In this study, patients receive standard systemic chemotherapy with modified FOLFIRINOX followed by stereotactic body radiation therapy (SBRT). After completion of chemoradiation, gemcitabine is delivered directly to the tumor through the arterial blood supply using the RenovoCath® catheter system. Gemcitabine is an FDA-approved chemotherapy drug for pancreatic cancer, and the study is evaluating a novel method of delivering the drug rather than a new medication.
The primary objective of the study is to assess the safety and tolerability of neoadjuvant TAMP-delivered gemcitabine in this treatment setting. Secondary objectives include evaluation of surgical margin status and pathologic tumor regression following surgical resection. Exploratory analyses will examine relapse-free survival. Results from this study will help determine whether this locoregional chemotherapy approach can be safely integrated into neoadjuvant treatment strategies for patients with borderline resectable PDAC.
This Phase Ib/II, single-arm study evaluates the safety and feasibility of adding trans-arterial microperfusion (TAMP) delivery of gemcitabine to standard neoadjuvant therapy for patients with borderline resectable PDAC. In this study, patients receive standard systemic chemotherapy with modified FOLFIRINOX followed by stereotactic body radiation therapy (SBRT). After completion of chemoradiation, gemcitabine is delivered directly to the tumor through the arterial blood supply using the RenovoCath® catheter system. Gemcitabine is an FDA-approved chemotherapy drug for pancreatic cancer, and the study is evaluating a novel method of delivering the drug rather than a new medication.
The primary objective of the study is to assess the safety and tolerability of neoadjuvant TAMP-delivered gemcitabine in this treatment setting. Secondary objectives include evaluation of surgical margin status and pathologic tumor regression following surgical resection. Exploratory analyses will examine relapse-free survival. Results from this study will help determine whether this locoregional chemotherapy approach can be safely integrated into neoadjuvant treatment strategies for patients with borderline resectable PDAC.
开始日期2026-12-01 |
申办/合作机构 |
NCT06274879
Safety of Biliary Intraductal Radiofrequency Ablation in Patients With Unresectable Extrahepatic Biliary Tract Cancer (EBTC) Undergoing Systemic Anti-tumor Therapy: a Phase II, Multi-center, Randomized, and Controlled Study (Ablatio-bilica)
The goal of this clinical trial is to provide evidence for the general tolerability of radiofrequency ablation (bRFA) in patients with unresectable bile duct cancer undergoing systemic palliative treatment consisting of systemic anti-tumor therapy with or without immune-checkpoint-inhibitor (ICI). The main question it aims to answer is whether it is safe to combine systemic anti-tumor therapy with or without ICI with and bRFA.
Participants will be assigned to either the control group or the experimental group. In the control group, the standard of care consists of endoscopy with stent placement in the bile duct and systemic anti-tumor therapy, whereas in the experimental group, bRFA will be performed in addition to the standard of care. Participants will be followed up for 6 months, during the follow-up, the stage of the tumor, blood examination, the duration of the stent from the insertion until its failure, adverse events and quality of life will be examined.
Researchers will compare the standard of care alone to the experimental group to see if the additional bRFA procedure causes higher or no difference in adverse events rate.
Participants will be assigned to either the control group or the experimental group. In the control group, the standard of care consists of endoscopy with stent placement in the bile duct and systemic anti-tumor therapy, whereas in the experimental group, bRFA will be performed in addition to the standard of care. Participants will be followed up for 6 months, during the follow-up, the stage of the tumor, blood examination, the duration of the stent from the insertion until its failure, adverse events and quality of life will be examined.
Researchers will compare the standard of care alone to the experimental group to see if the additional bRFA procedure causes higher or no difference in adverse events rate.
开始日期2026-05-20 |
申办/合作机构  Insel Gruppe AG [+1] |
100 项与 吉西他滨 相关的临床结果
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100 项与 吉西他滨 相关的转化医学
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100 项与 吉西他滨 相关的专利（医药）
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18,767
项与 吉西他滨 相关的文献（医药）2026-12-31·Future Science OA
Clinical efficacy of 2-week and 3-week albumin-bound paclitaxel therapy for advanced pancreatic cancer
Article
作者: Su, Zhimin ; Li, Zhiyong ; Shen, Feng ; Jiang, Jiana
OBJECTIVE:
We aim to compare the clinical efficacy and safety of albumin-bound paclitaxel (nab-PTX) (125 mg/m2, q2w) for two weeks and (125 mg/m2, d1, d8, q3w) for three weeks in the first-line treatment of advanced pancreatic cancer.
METHODS:
The medical records of patients with advanced pancreatic cancer who received nab-PTX for 2 weeks and 3 weeks, combined with gemcitabine, from July 2018 to January 2023, were retrospectively analyzed. The efficacy and adverse reactions of the two groups of patients were compared.
RESULT:
A total of 64 patients were included. The median progression-free survival (mPFS) of the 2-week group was 5.6 months, while the 3-week group was 7.8 months. The median overall survival (mOS) of the 2-week group was 14.0 months, while the 3-week group was 14.7 months. The multivariate analysis showed that a physical fitness status score of 0-1 was an independent factor with better OS, while metastatic sites ≥ 3 were related to poor OS. The incidence of leukopenia or neutropenia, neurotoxicity, fatigue, and poor appetite in the 2-week group was lower than that in the 3-week group.
CONCLUSION:
The clinical efficacy of nab-PTX in the 2-week and dose intensive 3 week did not show significant difference, but the 2-week treatment group had better tolerance and safety.
2026-12-31·Autophagy reports
TFEB confers resistance against the chemotherapeutic agent CX-5461
Article
作者: Boucher, Marie-Josée ; Bessy, Laure ; McDuff, Florence ; Marchand, Benoît ; Rolland, Marjorie
Identifying mechanisms underlying chemoresistance is essential for improving the efficacy of chemotherapeutic drugs. Previously, we showed that cancer cells respond to gemcitabine by activating protective signals dependent on the master regulator of autophagy and lysosomal biogenesis, transcription factor EB (TFEB). However, how gemcitabine triggers these protective responses remains elusive. While gemcitabine primarily aims at disrupting DNA replication, it is also suspected to induce nucleolar stress. In this study, we aimed to examine the effect of gemcitabine on nucleolar stress and investigate whether nucleolar stress inducers could trigger TFEB-dependent protective signals. Besides gemcitabine causing nucleolar stress, the anticancer agent CX-5461, primarily designed to induce nucleolar stress, promoted TFEB nuclear accumulation. Interfering with TFEB improved the sensitivity of cancer cells to both CX-5461 and gemcitabine. Our findings suggest that TFEB provides broad protection against the stress caused by chemotherapeutic drugs, representing a promising target for intercepting chemoresistance and improving the efficacy of anticancer agents.
2026-12-31·Gut Microbes
Exploring the gut microbiome and metabolomic interactions of antimetabolite drugs to optimize therapy
Review
作者: Zhao, Libo ; Chen, Jingyang ; Wang, Yanan ; Li, Xiaona ; Xu, Lei
Antimetabolite drugs are cornerstones in treating various cancers and autoimmune diseases; however, their clinical utility is often hampered by systemic toxicity caused by drug-induced gut microbiota dysbiosis. Predicting patient responses remains a significant challenge. Several studies have highlighted the influence of gut microbiota on antimetabolite treatment outcomes, revealing complex bidirectional interactions between the drugs and microbial communities. This review synthesizes the effects of common antimetabolites (including 5-fluorouracil, methotrexate, gemcitabine, capecitabine, 6-mercaptopurine, and thioguanine) on gut microbial communities and outlines a framework (pharmacokinetics, endogenous metabolite production, immune modulation, and apoptotic pathway modulation) for assessing chemotherapy-microbiota interactions. Additionally, potential microbial biomarkers for predicting treatment responses and strategies for manipulating the gut microbiota to enhance therapeutic efficacy are discussed. Therefore, advances in methodologies such as metagenomics and real-time microbial monitoring will be essential for unraveling these interactions and promoting the precise application of antimetabolite drugs.
4,196
项与 吉西他滨 相关的新闻（医药）2026-06-01
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胰腺癌一直是实体瘤治疗中最难突破的领域之一。尤其是在转移性胰腺导管腺癌（mPDAC）中，患者一线治疗进展后，可选方案有限，后线治疗长期以化疗为主，疗效提升空间非常有限。
2026 ASCO 上，daraxonrasib（RMC-6236）III期 RASolute 302 研究公布主要和最终结果。研究显示，在既往治疗的转移性胰腺导管腺癌患者中，daraxonrasib 相较研究者选择的化疗，显著改善总生存期（OS）、无进展生存期（PFS）、客观缓解率（ORR）以及患者报告生活质量（QoL），达到所有主要和关键次要疗效终点。对于长期缺少有效创新治疗的胰腺癌而言，这组数据的意义不止于一项三期阳性研究，更在于 RAS 靶向治疗终于在胰腺癌中拿出了具有注册意义和临床分量的后期证据。
本期内容
01
所有终点达成丨胰腺癌后线治疗
02
不止于RAS G12，广泛人群获益
03
生活质量同步改善
04
从后线突破到一线探索
【01 所有终点达成丨胰腺癌后线治疗】
RASolute 302 是一项全球、多中心、随机、开放标签 III 期研究，纳入既往在转移性阶段接受过 1 线含氟嘧啶或吉西他滨方案治疗的 mPDAC 成年患者。
患者按照 1:1 随机接受 daraxonrasib 300 mg 每日一次口服治疗，或研究者选择的标准化疗方案，包括吉西他滨联合白蛋白紫杉醇、改良 FOLFIRINOX、脂质体伊立替康联合 5-FU/亚叶酸或 FOLFOX。研究双主要终点为 RAS G12 突变人群中的 OS 和 PFS，关键次要终点包括总体人群 OS、PFS、ORR 以及患者报告结局恶化时间。
结果显示，在 RAS G12 突变人群中，daraxonrasib 将中位 OS 从化疗组的 6.6 个月提高至 13.2 个月，死亡风险降低 60%（HR=0.40）。中位 PFS 从 3.5 个月延长至 7.3 个月，ORR 从 11.8% 提高至 33.2%。这意味着 daraxonrasib 不仅延缓疾病进展，也带来了明确的生存获益和更高的肿瘤缓解比例。
对于经治 mPDAC 这样预后极差、后线获益有限的治疗场景而言，OS、PFS 和 ORR 同时显著改善，取得阳性结果，实属难得。
02 生活质量同步改善
Daraxonrasib 这项研究最值得关注的地方，并不只是 RAS G12 突变人群中的阳性结果，而是总体人群中同样观察到了高度一致的疗效获益。
总体人群包括较少见 RAS 突变患者，以及未检测到 RAS 突变的患者。
结果显示，daraxonrasib 组中位 OS 仍为 13.2 个月，化疗组为 6.7 个月，HR 同样为 0.40；中位 PFS 分别为 7.2 个月和 3.6 个月；ORR 分别为 31.6% 和 11.2%。
这一点对胰腺癌治疗具有重要意义。PDAC 与 RAS 通路高度相关，但临床上患者的 RAS 突变谱并不完全一致，且真实世界中检测样本、检测时效和疾病进展速度都会影响精准分层治疗的实施。如果一个 RAS 通路靶向药物只能覆盖非常狭窄的突变亚型，其临床应用空间会受到限制。RASolute 302 总体人群结果提示，daraxonrasib 可能不只是一个特定突变亚型药物，而是有机会在更广泛的 RAS 驱动或 RAS 通路相关胰腺癌患者中建立治疗位置。当然，最终获批人群仍需等待监管机构审评结果，但从临床开发角度看，这已经明显拓宽了外界对其应用边界的想象。
03 生活质量同步改善
胰腺癌后线治疗不能只看影像学进展和生存曲线。转移性胰腺癌患者常伴随疼痛、消化功能受损、体重下降、体力衰退等问题，治疗能否延缓症状恶化、维持生活质量，是评价药物临床价值的重要维度。
RASolute 302 中，患者报告结局使用 EORTC QLQ-PAN26 和 EORTC QLQ-C30 问卷评估。结果显示，daraxonrasib 相较化疗显著延迟疼痛恶化时间和整体健康状态/生活质量恶化时间。疼痛恶化时间从 3.8 个月延长至 9.2 个月，整体健康状态/生活质量恶化时间从 2.6 个月延长至 5.7 个月。
这一结果进一步提高了研究的临床说服力。对于胰腺癌患者而言，ORR 提高可能不仅意味着肿瘤缩小，也可能转化为疼痛减轻、压迫症状缓解、治疗耐受性改善和治疗持续时间延长。
Daraxonrasib 在 OS、PFS、ORR 和患者报告结局上同时取得阳性，使其获益不再停留于单一统计终点，而更接近真实临床中医生和患者共同关注的问题：能否延长生存，能否控制疾病，能否减少症状负担，能否让患者维持更好的生活状态。
04 从后线突破到一线探索
安全性方面，daraxonrasib 并非没有管理压力。研究中，daraxonrasib 组几乎所有患者均出现治疗期间不良事件，治疗相关不良事件发生率为 97.9%。
不过，从严重程度和治疗持续性来看，daraxonrasib 相较化疗显示出一定优势。
其≥3级治疗相关不良事件发生率为 43.6%，低于化疗组的 57.5%；严重治疗相关不良事件为 10.8%，低于化疗组的 18.7%；治疗相关不良事件导致停药比例为 1.2%，明显低于化疗组的 11.2%。
Daraxonrasib 组需要重点管理的不良反应包括皮疹、口腔炎、肝酶升高等，同时研究中也报告了 1 例治疗相关肺炎死亡。
从产业和临床开发角度看，daraxonrasib 的下一步更值得关注。Revolution Medicines 已宣布计划通过 FDA Commissioner’s National Priority Voucher 试点项目提交新药上市申请，FDA 也已允许其在既往治疗、携带 RAS 突变的转移性 PDAC 患者中启动扩大用药治疗方案。该药物还已获得 FDA 突破性疗法认定和孤儿药资格。与此同时，daraxonrasib 正在 RASolute 303 研究中继续向一线转移性 PDAC 推进，探索单药或联合化疗对比化疗的疗效。
因此，RASolute 302 的意义不仅在于为经治转移性胰腺癌提供一个潜在新标准治疗选择，也在于重新确认了 RAS 通路在胰腺癌治疗中的可干预价值。过去，RAS 在胰腺癌中更多被视为核心驱动因素，却长期难以转化为有效药物。Daraxonrasib 的三期阳性结果说明，RAS 靶向治疗已经从概念验证走向后期临床兑现。后续真正决定其行业高度的，将是获批人群边界、真实世界安全性管理，以及一线研究能否继续复制并放大当前获益。
★
临床结果ASCO会议临床3期
2026-05-31
编者按：根据2026年美国临床肿瘤学会（ASCO）年会上公布的结果（摘要4507），EV-302/KEYNOTE-A39研究的后续分析显示，与化疗相比，EV+P方案在局部晚期或转移性尿路上皮癌（LA/mUC）患者中持续带来生存获益。该试验此前已证实EV+P方案的优越性，并将其确立为LA/mUC患者的一线标准治疗方案。这项新的分析将中位随访时间延长至约3.5年。“这表明最初的获益得以维持，”伦敦玛丽女王大学巴茨癌症研究所的Thomas Powles教授表示，“我们可能正在治愈一些晚期膀胱癌患者。这在采用这种联合疗法之前是无法想象的。”美国国家癌症研究所的Andrea B. Apolo教授在讨论中也强调了EV+P在该患者群体中的作用，并表示该组合“仍然是LA/mUC一线治疗的标准疗法，确实显示出显著、持久的疗效和长期OS”。
亮点抢先看：
1
此前已确立EV+P作为LA/mUC患者一线治疗新标准的EV-302/KEYNOTE-A39研究最新分析显示，与化疗相比，EV+P方案持续带来生存获益。
2
中位随访时间约为3.5年，EV+P组的中位总生存期（OS）为33.6个月，而化疗组为15.9个月，风险比为0.53（95% CI 0.45-0.63）。3.5年时，EV+P组的OS率为44.0%，而化疗组为24.6%。
3
EV+P组的客观缓解率（ORR）为67.5%，完全缓解率（CR）为30.4%。 45例患者（10.3%）直接达到完全缓解（CR），但88例患者（占总数的20.1%，占达到CR患者的66.2%）在达到CR之前先经历了部分缓解（PR）。从PR转化为CR的患者与直接达到CR的患者疗效相似。
生存数据分析
EV-302/KEYNOTE-A39研究纳入了886例未经治疗的LA/mUC患者，随机分配至两组，分别接受EV+P方案治疗直至疾病进展，或接受吉西他滨联合顺铂或卡铂方案治疗，最多6个疗程。这项新的分析评估了中位随访42.8个月后，在符合治疗意向的人群中，EV+P方案的安全性和有效性。
EV+P方案的中位OS为33.6个月，而化疗组为15.9个月，风险比为0.53（95% CI [0.45, 0.63]）。3.5年时，EV+P组的OS率为44.0%，而化疗组为24.6%。“通常疗效会有一些波动，但我们没有观察到这种情况，”Powles教授说。
△ EV-302研究ITT人群OS分析
EV+P组共有192例患者（43.4%）接受了后续抗癌治疗，其中最常见的是铂类化疗（30.5%）；这些患者的ORR为20.7%。Apolo教授指出，较低的缓解率可能是由于后续抗癌治疗的报告不完整，因为这并非该研究的主要目标。
EV+P组的ORR为67.5%，CR为30.4%。化疗组的ORR为44.2%，CR为14.5%。在EV+P组中，45例患者（10.3%）直接达到CR，但88例患者（占总数的20.1%，占达到CR患者的66.2%）在达到CR之前先经历了PR。“这表明治疗反应存在演变过程，”Powles教授指出，并非所有肿瘤都能通过“短期强化治疗”立即产生反应。
Apolo教授补充说，这种转化可能是由于部分患者的疾病负荷较高或耐药性更强。“如果他们获得了部分缓解，我们仍然可以期待患者最终能够达到完全缓解，而这些患者对这种疗法的疗效非常显著，”她说道。
缓解转化
在PR后达到CR的患者中，中位达到CR的时间为EV+P治疗6.6个月。所有133例达到CR的患者中，中位CR达到时间为4.3个月。
从PR转化为CR的患者与直接达到CR的患者疗效相似。在所有达到CR的患者中，EV+P组的中位OS尚未达到，而化疗组为56.7个月（HR 0.364，95% CI [0.195, 0.679]）；两组的3.5年生存率分别为83.6%和68.0%。在从PR转化为CR的患者中，EV+P组的3.5年生存率为82.4%。
毒性可控
Apolo教授指出，在12个月（41.8%）和2年（23.2%）时，仍有相当比例的患者能够坚持治疗。她表示，通常情况下，毒性反应会限制这种长期治疗。她认为，这很可能是由于治疗中断和剂量减少的比例相对较高，而这些措施可以延长整体治疗持续时间。60.0%的患者因治疗相关不良事件而中断了EV治疗，50.7%的患者因治疗相关不良事件而中断了帕博利珠单抗治疗。对于接受联合治疗超过一年的患者，这两个比例分别为75.5%和65.2%；对于接受治疗两年的患者，这两个比例分别为74.5%和64.7%。
43.0%的患者因治疗相关不良事件而减少了EV剂量；在接受治疗超过一年的患者中，这一比例为65.8%；在接受治疗超过两年的患者中，这一比例为70.6%。尽管治疗时间更长，但能够接受 EV+P 治疗超过1年或2年的患者，其安全性与总体人群相似。
“就在数年前，膀胱癌还是一种致命的疾病，” Apolo教授指出，“此次试验的最新初步结果令人振奋，患者生存期的显著延长标志着膀胱癌治疗已进入一个全新时代。”
▌参考文献：
1. Powles T, Valderrama BP, Gupta S, et al. Enfortumab vedotin and pembrolizumab in untreated advanced urothelial cancer. N Engl J Med. 2024;390(10):875-888.
2. Powles T, et al. Enfortumab vedotin plus pembrolizumab (EV+P) vs chemotherapy for previously untreated locally advanced or metastatic urothelial carcinoma (la/mUC): 3.5-year follow-up and response analyses from the phase 3 EV-302 study. J Clin Oncol 44, 2026 (suppl 16; abstr 4507)
（来源：《肿瘤瞭望-泌尿时讯》编辑部）
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2026-05-31
BMC Medicine [Jour] AND 24[volume] AND 1[issue]
生物医学中心 - 医学 24卷 1期
https://link.springer.com/journal/12916/volumes-and-issues/24-1
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Article: 276
Compound climate extreme events and associated health impacts: a scoping review
复合气候极端事件及其相关健康影响：一项范围性综述
Shifali MathewsCaitlin WalkerJaime Madrigano
Research 20 March 2026
Article: 275
Part of 1 collection:Climate change and human health
所属专题合集：气候变化与人类健康
Smoking history, eligibility for lung cancer screening and risk of death by lung cancer or other causes -- a longitudinal, time-variable analysis of the EPIC-Heidelberg cohort
吸烟史、肺癌筛查资格以及死于肺癌或其他原因的风险——对EPIC-海德堡队列的纵向、时变分析
Yue ChenSrimanti DuttaRudolf Kaaks
Research 28 April 2026
Article: 274
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Cortical functional hierarchy disruption following subcortical stroke
皮质功能层级在皮层下卒中后的破坏
Ke WuGang LiuGaolang Gong
Research 19 March 2026
Article: 273
Characterizing the effects of genetic liability to autoimmune conditions on pregnancy outcomes using Mendelian randomization
利用孟德尔随机化方法表征遗传易感性对自身免疫性疾病患者妊娠结局的影响
Elisabeth AitonNancy S. McBrideMaria Carolina Borges
Research 19 March 2026
Article: 272
Dystrophin-gene mutation location influences severity of electroretinogram defects in mouse models of Duchenne muscular dystrophy
杜氏肌营养不良症小鼠模型中，肌营养不良蛋白基因突变位置对视网膜电图缺陷严重程度的影响
André Maurício Passos LiberMirella BarboniCyrille Vaillend
Research 25 April 2026
Article: 271
Personalizing the treatment of head and neck cancer in vitro: The 3D-OTC model
体外个性化治疗头颈部肿瘤：三维器官芯片（3D-OTC）模型
Fabian StögbauerTobias WeiserBarbara Wollenberg
Research 25 April 2026
Article: 270
Part of 1 collection:Organoids: connecting molecular insights and clinical practice
所属专题合集：类器官：连接分子见解与临床实践
Risk factor profiles for infections in individuals with type 2 diabetes: a prospective cohort study
2型糖尿病患者感染的风险因素特征：一项前瞻性队列研究
Han-Cheng YuJi-Juan ZhangYun-Fei Liao
Research 18 March 2026
Article: 269
Part of 1 collection:Diabetes and infectious disease
所属专题合集：糖尿病与感染性疾病
Cause-specific years of life lost attributable to non-optimal body mass index by county, sex, race, and ethnicity in the USA, 2000–2019: a systematic analysis of health disparities
2000-2019年美国按县、性别、种族和民族划分的非最佳体重指数导致的特定原因寿命损失年数：一项关于健康差异的系统分析
GBD US Health Disparities CollaboratorsFarah MouhannaLaura Dwyer-Lindgren
Research 18 March 2026
Article: 268
Global and regional prevalence, burden, and risk factors for MASLD in children and adolescents aged 5 to 24years: a systematic review, meta-analysis, and modeling study
全球和区域5至24岁儿童和青少年代谢相关脂肪性肝病（MASLD）的患病率、负担及风险因素：一项系统综述、荟萃分析和建模研究
Yunfei LiuShan CaiSusan M. Sawyer
Research 18 March 2026
Article: 267
Relative leukocyte telomere length and the risk of lung cancer progression in individuals with pulmonary nodules
相对白细胞端粒长度与肺结节患者肺癌进展风险的关系
Yuanyuan WuDong SunFeifei Cheng
Research 18 March 2026
Article: 266
Effects of Tai Chi combined with transcranial direct current stimulation on pain in knee osteoarthritis: a randomized controlled neuroimaging trial
太极拳结合经颅直流电刺激对膝骨关节炎疼痛的影响：一项随机对照神经影像学试验
Xuefeng LiuTong TangJing Tao
Research 17 March 2026
Article: 265
DNA hypermethylation of choline kinases drives blockage of choline-phosphatidylcholine biosynthesis: lipidomic biomarkers and epigenetic insights of hepatic steatosis induced by arsenic
胆碱激酶DNA高甲基化驱动胆碱-磷脂酰胆碱生物合成受阻：砷诱导的肝脂肪变性的脂质组学生物标志物及表观遗传学见解
Qiwen FuQi WangLu Ma
Research 17 March 2026
Article: 264
Dynamics of Mpox epidemics by the interplay of COVID-19 pandemic in Africa
非洲猴痘（Mpox）流行与新冠肺炎（COVID-19）大流行相互作用下的猴痘流行病学动态
Oyewole K. OyedeleNifarta P. AndrewAlash’le Abimiku
Research 17 March 2026
Article: 263
Part of 1 collection:Mpox: Epidemiology, prevention, and treatment
所属专题合集：猴痘：流行病学、预防和治疗
SPP1high fibrogenic macrophages mediate protective fibrotic remodeling and promote vascular stability in hypertension-associated aortic dissection
SPP1高表达成纤维性巨噬细胞介导保护性纤维化重塑并促进高血压相关主动脉夹层的血管稳定性
Shuai ZhaoXiumeng HuaJiangping Song
Research 16 March 2026
Article: 262
Longitudinal associations between body fat mass and cardiovascular outcomes among Chinese children: mediation by cardiometabolic risk factors
中国儿童身体脂肪量与心血管结局之间的纵向关联：通过心脏代谢风险因素的中介作用
Hui YangQin LiuBo Xi
Research 16 March 2026
Article: 261
The timing of the commencement of pulmonary rehabilitation in hospitalized patients with acute exacerbation of COPD: a systematic review and network meta-analysis
住院慢性阻塞性肺疾病急性加重患者开始肺康复治疗的时机：一项系统综述和网络荟萃分析
Peilin JiaHailong ZhangLongyu Wang
Research 16 March 2026
Article: 260
Correction: Vegetable intake and the risk of bladder cancer in the BLadder Cancer Epidemiology and Nutritional Determinants (BLEND) international study
更正：膀胱癌流行病学和营养决定因素（BLEND）国际研究中蔬菜摄入量与膀胱癌风险的关系
Evan Yi-Wen YuAnke WesseliusMaurice P. Zeegers
Correction 22 April 2026
Article: 259
Comparative efficacy of neoadjuvant short-course versus long-course radiotherapy-based regimens with or without immunotherapy for locally advanced pMMR rectal cancer: a systematic review and network meta-analysis
基于放疗的新辅助短疗程与长疗程治疗方案（联合或不联合免疫治疗）对局部晚期错配修复功能正常（pMMR）型直肠癌的疗效比较：一项系统综述与网状荟萃分析
Liqing LiXiaoyao MengTingshi Su
Research 14 March 2026
Article: 258
Association between bariatric surgery and long-term ability to perform household tasks in the Swedish Obese Subjects study: a controlled prospective cohort study
瑞典肥胖受试者研究：减肥手术与长期从事家务能力之间的关联——一项对照前瞻性队列研究
Petra BrembeckJohanna C. Andersson-AssarssonPer-Arne Svensson
Research 18 April 2026
Article: 257
Part of 1 collection:Weight loss interventions and their health impacts
所属专题合集：减重干预措施及其健康影响
The role of male foetal sex on maternal and neonatal outcomes in pregnancies complicated by gestational diabetes—secondary analysis of a randomised placebo controlled clinical trial of metformin in gestational diabetes (EMERGE)
男性胎儿性别对妊娠期糖尿病合并妊娠的母婴预后的影响——妊娠期糖尿病二甲双胍随机对照安慰剂临床试验（EMERGE）的二次分析
Christine NewmanAlberto Alvarez-IglesiasFidelma Dunne
Research 12 March 2026
Article: 256
Part of 1 collection:Diagnosis and management of gestational diabetes
所属专题合集：妊娠期糖尿病的诊断与管理
Downregulated lysyl oxidase in plasma extracellular vesicles: a biomarker linked to brain metastasis risk in lung adenocarcinoma
血浆细胞外囊泡中赖氨酰氧化酶表达下调：与肺腺癌脑转移风险相关的生物标志物
Jing LiYu PeiYi Liu
Research 12 March 2026
Article: 255
The influence of age-dependent susceptibility on RSV transmission dynamics and immunisation population-level impact
年龄依赖性易感性对呼吸道合胞病毒（RSV）传播动力学及免疫接种人群层面影响的研究
Chenkai ZhaoYuhe ZhangHarish Nair
Research 11 March 2026
Article: 254
A human-derived Bacteroides strain attenuates depressive-like behavior in a rat model of social defeat-induced stress
一株人源拟杆菌属菌株可减轻社会挫败诱导应激大鼠模型的抑郁样行为
Marisol I. DothardMariaelena CaboniPhilip Strandwitz
Research 10 March 2026
Article: 253
Adverse events in both childhood and adulthood are associated with molecular, clinical and functional markers of ageing
童年和成年期的不良事件均与衰老的分子、临床和功能标志物相关
Monica AasThole H HoppenJulian Mutz
Research 28 April 2026
Article: 252
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Genetic predisposition to high BMI, ultra-processed food consumptions in childhood, and adiposity in young adulthood: a 17-year prospective cohort study of 3061 individuals
高BMI遗传易感性、儿童期超加工食品摄入与成年早期肥胖：一项对3061例个体进行的为期17年的前瞻性队列研究
Ziyi ZhouQiaosen ChenFrederick K. Ho
Research 16 April 2026
Article: 251
Enhanced predictive performance of artificial intelligence in individualized ovarian stimulation of in vitro fertilization: a retrospective cohort study
人工智能在体外受精个体化卵巢刺激中的预测性能提升：一项回顾性队列研究
Guiquan WangMinyue TangYimin Zhu
Research 10 March 2026
Article: 250
PCDSOS: a novel clinical predictive tool for screening primary ciliary dyskinesia in adult bronchiectasis patients—a multicenter derivation and external validation study
PCDSOS：一种用于筛查成人支气管扩张症患者原发性纤毛运动障碍的新型临床预测工具——一项多中心推导及外部验证研究
Wangji ZhouLin WangXinlun Tian
Research 10 March 2026
Article: 249
Detection rate and mutational landscape in extracranial arteriovenous malformations: a cohort study
颅外动静脉畸形的检出率及突变谱：一项队列研究
Vanessa F. SchmidtDenny Schanzefor the APOLLON Investigators
Research 16 April 2026
Article: 248
Kinetics of antibodies and risk of respiratory syncytial virus infection: a longitudinal cohort in Taizhou City, eastern China
抗体动力学与呼吸道合胞病毒感染风险：中国东部台州市的一项纵向队列研究
Qiang WangDavid HodgsonWeibing Wang
Research 09 March 2026
Article: 247
Cell therapy strategies for organ regeneration
器官再生的细胞治疗策略
L. PapamichailL. J. W. van der LaanM. J. Hoogduijn
Review 25 February 2026
Article: 246
Transcutaneous spinal cord stimulation combined with robot-assisted gait training to improve mobility and balance in spinal cord injury: intramuscular electromyography as a biomarker for functional recovery
经皮脊髓电刺激联合机器人辅助步态训练改善脊髓损伤患者的行动能力和平衡能力：肌内肌电图作为功能恢复的生物标志物
Abdul RashadHe XijingMuhammad Asif
Registered Report 09 March 2026
Article: 245
Neoadjuvant camrelizumab combined with radiotherapy as a chemotherapy-sparing approach for resectable locally advanced esophageal squamous cell carcinoma: a phase II clinical trial (ESOCORT-NIRT)
新辅助卡瑞利珠单抗联合放疗作为可切除局部晚期食管鳞癌的免化疗方案：一项II期临床试验（ESOCORT-NIRT）
Maohui ChenYizhou HuangBin Zheng
Research 09 March 2026
Article: 244
FLASH radiotherapy preserves systemic and tissue homeostasis while maintaining antitumor efficacy
FLASH放疗在保持抗肿瘤疗效的同时维持全身及组织稳态
Giulia FuriniEduarda Mota da SilvaMargherita Maffei
Research 26 February 2026
Article: 243
fMRI-guided V1-targeted rTMS improves depressive symptoms in adolescents and young adults with bipolar disorder: a double-blind randomized controlled trial
功能磁共振成像引导的V1区靶向重复经颅磁刺激改善青少年及青年双相情感障碍患者的抑郁症状：一项双盲随机对照试验
Xudong ZhaoHetong ZhouMinmin Wang
Research 07 March 2026
Article: 242
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童及青少年精神病学
Impairment of brain short association fibers across clinical stages in amyotrophic lateral sclerosis: a new biomarker mirroring disease progression
肌萎缩侧索硬化症临床各阶段脑短联结纤维受损情况：一种反映疾病进展的新型生物标志物
Nao-Xin HuangZi-Wei CaiHua-Jun Chen
Research 06 March 2026
Article: 241
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新动态
Social frailty and the risk of progression from health to physical, psychological, and cognitive multimorbidity: a prospective multi-cohort study
社会脆弱性与从健康状态进展至身体、心理及认知多病共存状态的风险：一项前瞻性多队列研究
Yaguan ZhouHtet Lin HtunYi Guo
Research 06 March 2026
Article: 240
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学及风险因素的作用
Association between early life constituent-specific PM2.5 exposure and child development and the moderating role of greenness: a nationwide study in China
中国全国范围内早期生命特定成分PM2.5暴露与儿童发育的关联及绿地调节作用的研究
Ruili LiXiaoguo ZhengXiaoning Lei
Research 06 March 2026
Article: 239
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童及青少年精神病学
Intravenous thrombolysis versus standard medical therapy in minor stroke patients with large vessel severe stenosis or occlusion: a systematic review and meta-analysis
静脉溶栓与标准药物治疗轻型卒中合并大血管重度狭窄或闭塞患者的系统综述与荟萃分析
Tianhao ZhangLin TongZhigang Liang
Research 06 March 2026
Article: 238
Long-term risk of offspring type 1 and type 2 diabetes following maternal gestational diabetes mellitus: a nationwide birth cohort study with 10-year follow-up
母亲妊娠期糖尿病后子女患1型和2型糖尿病的长期风险：一项为期10年随访的全国出生队列研究
Joon Ho MoonHan Na JungSung Hee Choi
Research 06 March 2026
Article: 237
Part of 1 collection:Diagnosis and management of gestational diabetes
所属专题合集：妊娠期糖尿病的诊断与治疗
Parental income in childhood and health outcomes across age groups: a register-based study from Norway
童年期父母收入与各年龄段健康结局：一项基于挪威登记数据的研究
Bjørn-Atle RemeHans Fredrik SundeJonathan Wörn
Research 06 March 2026
Article: 236
AI-based quality control was associated with improved fetal ultrasound image quality in low-resource settings: a real-world multicenter study from West China
基于人工智能的质量控制可改善低资源环境下胎儿超声图像质量：一项来自中国西部的现实多中心研究
Jianxin ZhaoYao TangYong Huang
Research 06 March 2026
Article: 235
Reply to: Intraoperative use of sodium oxybate to prevent post-operative delirium in older patients undergoing major orthopedic surgery
回复：术中使用羟丁酸钠预防老年患者接受大骨科手术后谵妄
Meiying CuiHang XuePing Zhao
Matters Arising 13 April 2026
Article: 234
Hypothesis-free evaluation of circulating metabolome provides cell-specific insights regarding the role of energy substrate availability in amyotrophic lateral sclerosis
无假设的循环代谢组学评估为肌萎缩侧索硬化症中能量底物可用性的细胞特异性作用提供见解
Elham AlhathliJohnathan Cooper-KnockPamela J. Shaw
Research 06 March 2026
Article: 233
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新动态
Intraoperative use of sodium oxybate to prevent postoperative delirium in older patients undergoing major orthopedic surgery
术中使用羟丁酸钠预防老年患者接受大骨科手术后谵妄
Fu-Shan XueDan-Feng WangXiao-Chun Zheng
Matters Arising 13 April 2026
Article: 232
Statin therapy and stroke risk in patients with hypercholesterolaemia: a population-based longitudinal study using electronic health records in South London
他汀类药物治疗与高胆固醇血症患者卒中风险：一项基于南伦敦电子健康记录的纵向人群研究
Marc DelordAbdel Douiri
Research 05 March 2026
Article: 231
Thermal ablation versus hepatectomy for solitary colorectal liver metastases up to 5 cm: a multicenter target trial emulation on safety, efficacy, and cost-effectiveness
热消融与肝切除术治疗直径达5厘米的孤立性结直肠癌肝转移：一项关于安全性、疗效及成本效益的多中心目标试验模拟研究
Jianming LiLu LiPing Liang
Research 05 March 2026
Article: 230
Why hyperinsulinemia is detrimental to weight loss: insights from type 1 diabetes
为何高胰岛素血症不利于减重：来自1型糖尿病的见解
Stephan MartinKerstin KempfHubert Kolb
Debate 10 April 2026
Article: 229
Part of 1 collection:Weight loss interventions and their health impacts
所属专题合集：减重干预措施及其健康影响
Interventions to prevent and treat multiple long-term conditions and their consequences across the life course: concepts and definitions
预防和治疗多种长期疾病及其在生命周期中后果的干预措施：概念与定义
Miles D. WithamGuruprasad P. AithalThe Multiple Long-Term Conditions Cross-NIHR Collaboration Interventions and Prevention Workstream
Forum 10 April 2026
Article: 228
Effectiveness of nirmatrelvir/ritonavir and molnupiravir on post-COVID diabetes risk among an older adult cohort: a target trial emulation study
奈玛特韦/利托那韦和莫努匹韦对老年人群新冠后糖尿病风险的影响：一项目标试验模拟研究
Zihao GuoYuchen WeiKa Chun Chong
Research 17 March 2026
Article: 227
Part of 1 collection:Diabetes and infectious disease
所属专题合集：糖尿病与传染病
Iron deficiency and dementia risk: evidence from the Swedish population-based cohort study AMORIS
瑞典基于人群的队列研究AMORIS中铁缺乏与痴呆风险的证据
Mozhu DingAlexandra WennbergKarin Modig
Research 08 April 2026
Article: 226
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Effects of ultrasound-guided stellate ganglion block in poststroke bulbar palsy: a double-blind placebo-controlled trial
超声引导下星状神经节阻滞对脑卒中后球麻痹的影响：一项双盲安慰剂对照试验
Hongji ZengWeihong ZhangXi Zeng
Research 04 March 2026
Article: 225
Dual-utility ctDNA in diffuse large B-cell lymphoma: integrated genotyping unveils minimal residual disease dynamics and subtype-specific clonal evolution
双用途循环肿瘤DNA在弥漫性大B细胞淋巴瘤中的应用：整合基因分型揭示微小残留病灶动态变化及亚型特异性克隆演变
Jin-Hua LiangYi-Fan WuWei Xu
Research 04 March 2026
Article: 224
Risks of non-breast, non-ovarian cancers for BRCA1 and BRCA2pathogenic variant carriers: a prospective cohort study
BRCA1和BRCA2致病性变异携带者患非乳腺、非卵巢癌的风险：一项前瞻性队列研究
Ruotong YangRobert J. MacInnisShuai Li
Research 04 March 2026
Article: 223
Cardiovascular outcomes of intensive blood pressure control in patients with and without metabolic dysfunction-associated fatty liver disease: post hoc analysis of the CRHCP trial
在伴有和不伴有代谢功能障碍相关脂肪性肝病的患者中，强化血压控制的心血管预后：CRHCP试验的事后分析
Songyue LiuYangzhi YinXiaofan Guo
Research 04 March 2026
Article: 222
The role of COPD and inhaled corticosteroids in major adverse cardiovascular events in cardiovascular-kidney-metabolic populations
慢性阻塞性肺疾病和吸入性糖皮质激素在心血管-肾脏-代谢人群主要不良心血管事件中的作用
Anne E. IoannidesEmily L. GraulJennifer K. Quint
Research 04 March 2026
Article: 221
Ethnic differences in the burden of cardiovascular disease risk factors among adult residents of London: the TOGETHER study
伦敦成年居民心血管疾病风险因素负担的种族差异：TOGETHER研究
Fotios BarkasMalo DirouKausik K. Ray
Research 03 March 2026
Article: 220
Development of a novel prognostic assessment tool for recurrent respiratory papillomatosis
复发性呼吸道乳头瘤病新型预后评估工具的开发
Satoshi YamadaTaro IkegamiKiyoshi Misawa
Research 16 April 2026
Article: 219
Response to: Matters Arising in relation to “Evaluating agreement between individual nutrition randomised controlled trials and cohort studies – a meta-epidemiological study”
针对“评估个体营养随机对照试验与队列研究之间的一致性——一项元流行病学研究”的相关问题探讨
Julia StadelmaierGina BantleLukas Schwingshackl
Matters Arising 09 April 2026
Article: 218
Concordance between nutritional cohorts and randomized trials: biological confirmation or statistical consequence? A re-analysis of Stadelmaier et al.
营养队列研究与随机试验之间的一致性：生物学证实还是统计学结果？对Stadelmaier等人的研究再分析
Matthew CalkinsIsaac NúñezAdrian Soto-Mota
Matters Arising 09 April 2026
Article: 217
Multimorbidity patterns and 15-year trajectories of physical performance: a population-based study
多病共存模式与15年身体机能变化轨迹：一项基于人群的研究
Francesco PalmeseDavide Liborio VetranoFederico Triolo
Research 25 March 2026
Article: 216
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
The need for clinical studies assessing whether weight loss improves functional outcome after stroke in diabetes
评估减肥是否改善糖尿病患者中风后功能预后的临床研究需求
Ellen VercalsterenMichael V. MazyaCesare Patrone
Debate 24 March 2026
Article: 215
Targeting STE20-type kinase MST3 improves metabolic dysfunction-associated steatohepatitis without affecting hepatocellular carcinoma development in mice
靶向STE20型激酶MST3可改善小鼠代谢功能障碍相关脂肪性肝炎，且不影响肝细胞癌的发展
Jingjing ZhangXiangdong GongyeMargit Mahlapuu
Research 24 March 2026
Article: 214
Multimorbidity patterns and the subsequent risk of albuminuria: findings from the Stockholm Creatinine Measurements (SCREAM) project
多病共存模式与后续白蛋白尿风险：来自斯德哥尔摩肌酐测量（SCREAM）项目的研究结果
Giorgi BeridzePatrick B. MarkJuan-Jesus Carrero
Research 24 March 2026
Article: 213
Myeloid-derived immunosuppression of chimeric antigen receptor T cells in the neuronal microenvironment of glioblastoma
胶质母细胞瘤神经元微环境中髓系来源的免疫抑制对嵌合抗原受体T细胞的影响
Junyi ZhangJasmin von EhrYahaya A. Yabo
Research 13 March 2026
Article: 212
Associations of genetically predicted interleukin-6 and tumor necrosis factor signaling pathways with mortality among persons with colorectal cancer: a two-sample Mendelian randomization
基因预测的白细胞介素-6和肿瘤坏死因子信号通路与结直肠癌患者死亡率之间的关联：一项双样本孟德尔随机化研究
Martina BoukaKatharina NimptschTobias Pischon
Research 06 March 2026
Article: 211
Disruption of the angiopoietin-like system connects lipid homeostasis and hypothalamic dysfunction in ALS
血管生成素样系统紊乱将肌萎缩侧索硬化症中的脂质稳态与下丘脑功能障碍关联起来
Sruthi Sankari KrishnamurthyAdriana Zardini BuzattoFrancesco Roselli
Research 03 March 2026
Article: 210
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新动态
Day+30 detection of minimal residual FLT3-ITD by high-sensitivity PCR-NGS predicts relapse risk and guides post-transplant maintenance in AML
移植后第30天通过高灵敏度PCR-NGS检测微小残留FLT3-ITD可预测急性髓系白血病（AML）复发风险并指导移植后维持治疗
Shan JiangDan FengErlie Jiang
Research 03 March 2026
Article: 209
Early childhood weight gain and alanine aminotransferase at age 8: an adjunct study of the Japan Environment and Children’s Study
幼儿期体重增长与8岁时丙氨酸氨基转移酶水平：日本环境与儿童研究的一项辅助研究
Naw Awn J-PKeiko YamasakiNarufumi Suganuma
Research 03 March 2026
Article: 208
Anti-CD19 chimeric antigen receptor T-cell therapy for relapsed or refractory Philadelphia chromosome-positive B cell acute lymphoblastic leukemia: a multicenter retrospective study
抗CD19嵌合抗原受体T细胞疗法治疗复发或难治性费城染色体阳性B细胞急性淋巴细胞白血病：一项多中心回顾性研究
Jinglei YuFengmei SongGuoqing Wei
Research 03 March 2026
Article: 207
Identification of cryosensitive niches and a targetable FOS/AP‑1 program in the human ovarian cortex by single‑cell and spatial transcriptomics
通过单细胞和空间转录组学鉴定人类卵巢皮质中的冷敏感生态位及可靶向的FOS/AP-1程序
Fanghao GuoDi SunWen Li
Research 03 March 2026
Article: 206
Neoadjuvant camrelizumab combined with metronomic chemotherapy in patients with advanced esophageal squamous cell carcinoma: a pilot randomized phase 2 trial
卡瑞利珠单抗联合节拍化疗新辅助治疗晚期食管鳞状细胞癌：一项随机2期初步试验
Zhiming ChenWenshuai LiJie Liu
Research 03 March 2026
Article: 205
Part of 1 collection:Clinical trials for gastrointestinal cancer
所属专题合集：胃肠道癌症临床试验
Vericiguat for endothelial dysfunction and CRT response in non-responders: the VERCET prospective observational study
维利西呱治疗无反应者的内皮功能障碍和心脏再同步化治疗（CRT）反应：VERCET前瞻性观察研究
Celestino SarduLudovica Vittoria MarfellaRaffaele Marfella
Research 03 March 2026
Article: 204
Part of 1 collection:Cardiomyopathy and cardiac arrhythmias
所属专题合集：心肌病和心律失常
Assessment of antibody responses to Anopheles SG6-P1 and Aedes N-term 34kDa salivary peptides: a randomised human-challenge trial of controlled exposures to vector bites
评估针对按蚊SG6-P1和伊蚊N端34 kDa唾液肽的抗体反应：一项对媒介叮咬进行可控暴露的随机人体挑战试验
Victor ChaumeauEllen A. KearneyFreya J. I. Fowkes
Research 02 March 2026
Article: 203
Is random biopsy necessary for normal esophageal mucosa during chromoendoscopy? Evidence from a population-based cohort study
在色素内镜检查过程中，对于正常食管黏膜是否有必要进行随机活检？一项基于人群的队列研究证据
Wenlei YangMengfei LiuYang Ke
Research 02 March 2026
Article: 202
Sinusoidal cell–derived biomarker scores predict diagnosis and prognosis in chronic liver disease
窦状隙细胞来源的生物标志物评分可预测慢性肝病的诊断和预后
Sergi Guixé-MuntetAnabel Fernández-IglesiasJordi Gracia-Sancho
Research 28 February 2026
Article: 201
Anticholinergic drug burden and incident cardiovascular events: a population-based study
抗胆碱能药物负担与新发心血管事件：一项基于人群的研究
Nanbo ZhuMaria EriksdotterHong Xu
Research 28 February 2026
Article: 200
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Sensitive periods of BMI change from childhood to adulthood on subclinical cardiovascular outcomes: a 36-year prospective cohort study
从儿童期到成年期体重指数（BMI）变化对亚临床心血管结局影响的敏感期：一项为期36年的前瞻性队列研究
Hui YangTongshuai GuoJianjun Mu
Research 27 February 2026
Article: 199
Feasibility and preliminary efficacy of an art-making program to manage fear of cancer recurrence (AM-I-FCR) in lung cancer patients: a randomized controlled pilot study
艺术创作项目（AM-I-FCR）管理肺癌患者对癌症复发恐惧的可行性与初步疗效：一项随机对照试点研究
Jialing LinZhixuan KangFeifei Huang
Research 27 February 2026
Article: 198
Unveiling disparities in lung cancer care: a joint spatio-temporal analysis of multidisciplinary meeting presentation, supportive care screening, and diagnostic timeliness in Victoria
揭示肺癌诊疗差异：维多利亚州多学科会诊展示、支持性护理筛查及诊断及时性的联合时空分析
Getayeneh Antehunegn TesemaRob G. StirlingArul Earnest
Research 27 February 2026
Article: 197
Transcriptome-based high-frequency recurrence index predicts frequent recurrence in non-muscle-invasive bladder cancer after Bacillus Calmette-Guérin therapy
基于转录组的高频复发指数可预测卡介苗治疗后非肌层浸润性膀胱癌的频繁复发情况
Seung-Woo BaekYoung Joon ByunSeok Joong Yun
Research 27 February 2026
Article: 196
Life-course influence of birthweight and subsequent pathways on healthy aging: a Mendelian randomization study
出生体重对健康老龄化的终身影响及后续途径：一项孟德尔随机化研究
Lijie KongChun DouTiange Wang
Research 25 February 2026
Article: 195
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Routine inflammatory indices modify clonal hematopoiesis-related prognostic risk in patients undergoing percutaneous coronary intervention: a real-world cohort study
常规炎症指标改变接受经皮冠状动脉介入治疗患者的克隆性造血相关预后风险：一项现实队列研究
Xuxiang ShenYing SongXiangfeng Lu
Research 25 February 2026
Article: 194
Health experiences and outcomes of autistic and non-autistic adults with hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder
自闭症和非自闭症成年孤独症患者及非孤独症患者中患有高迁移率埃勒斯-丹洛斯综合征和高迁移率谱系障碍者的健康体验和预后
Catherine J. CromptonThemis N. EfthimiouKathryn M. Berg
Research 25 February 2026
Article: 193
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Effects of non-pharmacological interventions on sleep quality in older adults: a systematic review and network meta-analysis of randomized controlled trials
非药物干预措施对老年人睡眠质量影响：基于随机对照试验的系统综述和网络荟萃分析
Jia SongHeng DongShangfeng Tang
Research 25 February 2026
Article: 192
Cortical excitability mapping stratifies neurobiological subtypes of schizophrenia with genetic and molecular signatures
皮质兴奋性映射对具有遗传和分子特征的精神分裂症神经生物学亚型进行分层
Sixuan GuoYu ZhaoQiyong Gong
Research 25 February 2026
Article: 191
Minimum 18-week chemotherapy improves survival in locally advanced rectal cancer after neoadjuvant radiotherapy: a post hoc analysis of the STELLAR trial
新辅助放疗后局部晚期直肠癌患者接受至少18周化疗可改善生存率：STELLAR试验的事后分析
Tongzhen XuHuiying MaJing Jin
Research 25 February 2026
Article: 190
Helminth coinfections mitigate clinical, parasitological, and immune outcomes in Mozambican children with malaria
在莫桑比克患疟疾的儿童中，蠕虫共感染可减轻临床、寄生虫学和免疫学转归
Inocência CuambaRebeca SantanoCarlota Dobaño
Research 31 March 2026
Article: 189
Effectiveness of group-based art interventions for late-life depression: a systematic review and meta-analysis of randomized controlled trials
团体艺术干预对老年抑郁症的疗效：一项针对随机对照试验的系统综述和荟萃分析
Mohamad AzhdarlooRaziyeh AtaeiAbouzar Nazari
Research 24 February 2026
Article: 188
The associations of consultant sex on herding‑like prescribing behaviour: evidence from a web-based experiment with female primary care physicians in England
顾问性别对从众式处方行为的影响：来自一项针对英格兰女性初级保健医生的网络实验的证据
Sandro Tiziano StoffelMatthias SchwenkglenksBerna Cennet Özdemir
Research 24 February 2026
Article: 187
Tricarboxylic acid cycle metabolite index predicts adverse outcomes in acute myocardial infarction patients
三羧酸循环代谢物指数预测急性心肌梗死患者的不良预后
Ye WangPengyan WuBo Yu
Research 24 February 2026
Article: 186
Targeting cancer stem cells predicts response and reverses chemoresistance in ascites-derived ovarian cancer organoids
靶向癌症干细胞可预测腹水来源的卵巢癌类器官的反应并逆转化疗耐药性
Xiaoli ZhangWen ZhangHuiqin Guo
Research 24 February 2026
Article: 185
Neural vulnerability to stress in adolescents: a longitudinal study using polyconnectomic scoring of depression risk
青少年神经对压力的易感性：一项使用抑郁风险多连接组评分进行的纵向研究
Yuan LiuMeijuan LiJie Li
Research 24 February 2026
Article: 184
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Classification of ALS molecular subtypes: a literature review on machine learning applications and their clinical value
肌萎缩侧索硬化症分子亚型分类：机器学习应用及其临床价值的文献综述
John K. JammalEsteban A. GomezAlfredo Iacoangeli
Review 23 February 2026
Article: 183
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新动态
Can we protect refugee children from mental health problems?— a scoping review of modifiable factors to inform preventive interventions
我们能否保护难民儿童免受心理健康问题困扰？——一项旨在为预防性干预提供信息的可改变因素的范围性综述
Rita GonçalvesM J MarquesSónia Dias
Research 23 February 2026
Article: 182
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
The Trial Bank initiative to promote trustworthy living evidence for medication safety (PROMISE) of children: design and pilot validation
促进儿童用药安全可信实时证据（PROMISE）的试验库计划：设计与初步验证
Chang XuSuhail A. DoiPROMISE Collaborative Research Network
Research 21 February 2026
Article: 181
Is liquid biopsy a cost-effective method to diagnose Burkitt Lymphoma in children and young adults? A health economic evaluation in Tanzania
液体活检是否为诊断坦桑尼亚儿童和青年成人伯基特淋巴瘤的一种具有成本效益的方法？一项卫生经济学评估
Jingjing JiangLiz MorrellAI-REAL Consortium
Research 21 February 2026
Article: 180
The influence of immunohistochemistry-based subtypes on overall survival in breast cancer spine metastases: a systematic review and meta-analysis
基于免疫组织化学的亚型对乳腺癌脊柱转移总生存期的影响：一项系统综述和荟萃分析
Fon-Yih TsuangYun-Heng LiChung Liang Chai
Research 21 February 2026
Article: 179
Prenatal exposure to maternal asthma and asthma medication and neurodevelopmental outcomes: a population cohort study of 179,024 children
产前接触母体哮喘及哮喘药物与神经发育结局的关系：一项针对179,024例儿童的人群队列研究
Lama A. ShakhshirSarjit SinghMichael Fleming
Research 20 February 2026
Article: 178
First-in-human phase 1/2a study of T3011, an oncolytic HSV expressing IL-12 and PD-1 antibody, administered via intratumoral (IT) injection as monotherapy in advanced solid tumors, including recurrent or metastatic HNSCC
T3011（一种表达IL-12和PD-1抗体的溶瘤性单纯疱疹病毒）首次人体1/2a期研究：通过瘤内（IT）注射作为单一疗法治疗包括复发或转移性头颈部鳞状细胞癌在内的晚期实体瘤
Dongmei JiWenmin FuXichun Hu
Research 20 February 2026
Article: 177
Expanding access to cerebrovascular imaging with routine MRI for pre-surgical assessment of intracranial tumor patients: an AI model development and multi-center validation study
利用常规MRI扩大脑血管成像在颅内肿瘤患者术前评估中的应用范围：一项人工智能模型开发与多中心验证研究
Chaoyue ChenZhouyang HuangJianguo Xu
Research 20 February 2026
Article: 176
Changing landscape of physical fitness and urban–rural inequalities: evidence from 1.2 million children and adolescents over 20 years of urbanization
20年城市化进程中120万例儿童和青少年体质健康状况及城乡差异的变化
Shan CaiJiaxin LiYi Song
Research 19 February 2026
Article: 175
Efficacy and safety of anti-prediabetic drugs in patients with prediabetes: a Bayesian network meta-analysis
抗糖尿病前期药物在糖尿病前期患者中的疗效和安全性：一项贝叶斯网状荟萃分析
Yike WuZihan WangGuo Ma
Research 19 February 2026
Article: 174
Clonal haematopoiesis of indeterminate potential and risk of incident psychiatric disorders
Yuefeng YuChenyi WanNingjian Wang
意义未明的克隆性造血与新发精神障碍风险
Research 18 February 2026
Article: 173
Spatial characterization of intrahepatic fat deposition across steatotic liver disease subcategories: a multicenter study
脂肪性肝病各亚类中肝内脂肪沉积的空间特征：一项多中心研究
Yan-Ci ZhaoMin WangFeng Chen
Research 18 February 2026
Article: 172
Pregnancy outcomes among medically complex populations with high risk of pregnancy mortality in Virginia: a retrospective observational study
弗吉尼亚州妊娠死亡高风险医学复杂人群的妊娠结局：一项回顾性观察研究
Michael J. GreenLauren G. AndersonJonas J. Swartz
Research 18 February 2026
Article: 171
Maternal amino acid metabolites during pregnancy and preterm birth: results from two prospective cohort studies
孕期母体氨基酸代谢物与早产的关系：两项前瞻性队列研究的结果
Jingnan ChenYidan DongJu-Sheng Zheng
Research 18 February 2026
Article: 170
Correction: Trajectory of the body weight after drug discontinuation in the treatment of anti-obesity medications
更正：停用抗肥胖药物后体重的变化轨迹
Han WuWenjia YangLinong Ji
Correction 25 March 2026
Article: 169
Physical activity patterns and cardiovascular disease risk in adults with overweight or obesity: a prospective cohort study
超重或肥胖成人身体活动模式与心血管疾病风险：一项前瞻性队列研究
Kai MuYanan QiaoBo Xi
Research 16 February 2026
Article: 168
Part of 1 collection:Weight loss interventions and their health impacts
所属专题合集：减肥干预措施及其对健康的影响
Maternal migraine and offspring ADHD: triangulating the evidence
母亲偏头痛与后代多动症（ADHD）：多方证据综合分析
Yaxin LuoChristina DardaniEvie Stergiakouli
Research 14 February 2026
Article: 167
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
An autonomous siRNA delivery system targeting NLRP3: implications in Parkinson’s disease
靶向NLRP3的自主性小干扰RNA（siRNA）递送系统：在帕金森病中的潜在意义
Lishan LinZhizong LiZhong Pei
Research 12 February 2026
Article: 166
Lay descriptions of painful temporomandibular disorders—an international consensus proposal for Global Burden of Disease estimates
颞下颌关节紊乱病疼痛的通俗描述——全球疾病负担评估的国际共识提案
A. LövgrenP. LivP. Svensson
Research 17 March 2026
Article: 165
Association of soluble tumor necrosis factor receptor 1 with tau pathology, brain atrophy, and cognitive decline: a longitudinal study
可溶性肿瘤坏死因子受体1与tau蛋白病变、脑萎缩及认知功能下降的关联：一项纵向研究
Yutong ZhangLulu SunAlzheimer’s Disease Neuroimaging Initiative
Research 11 February 2026
Article: 164
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Particulate matter and respiratory health in middle-aged and older adults: disentangling size-fractionated and constituent-specific effects under China’s clean-air policies
颗粒物与中老年人呼吸系统健康的关系：厘清中国净化空气政策下不同粒径及成分的特定影响
Yujing ChenZhaoyan LiuYu-ming Chen
Research 11 February 2026
Article: 163
Part of 1 collection:Climate change and human health
所属专题合集：气候变化与人类健康
Clinical impact and cost-effectiveness of vaccinating infants and adolescents against invasive meningococcal B disease in the Netherlands
荷兰为婴儿和青少年接种针对侵袭性脑膜炎球菌B病的疫苗的临床影响和成本效益
Thomas OttenMirjam KnolAnneke Steens
Research 10 February 2026
Article: 162
Association between trajectories of sleep quality and postpartum depression: a group-based trajectory model and computer-simulated network analysis
睡眠质量轨迹与产后抑郁之间的关联：基于组别的轨迹模型和计算机模拟网络分析
Xiaoxiao MeiJinzhou YuZengjie Ye
Research 10 February 2026
Article: 161
Part of 1 collection:Sleep and mental health
所属专题合集：睡眠与心理健康
Understanding Japan’s mortality advantage: a comparison of mortality in independent and dependent older adults in Japan and Sweden
解读日本在死亡率方面的优势：日本与瑞典独立生活及依赖他人生活老年人的死亡率比较
Shunsuke MurataMarcus EbelingKarin Modig
Research 23 March 2026
Article: 160
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学及风险因素的作用
The Young Adult Sleep model: an evolving causal loop diagram of mental health dynamics
青年睡眠模型：心理健康动态演变的因果环路图
Jeroen F. UlemanRushd F. M. Al-ShamaNaja Hulvej Rod
Research 16 March 2026
Article: 159
Part of 1 collection:Sleep and mental health
所属专题合集：睡眠与心理健康
Oncostatin-M ligand-based CAR-T therapy displays robust anti-tumor activity against osteosarcoma
基于抑瘤素M配体的CAR-T疗法对骨肉瘤显示出强大的抗肿瘤活性
Daniel FeinbergVinayak UppinReshmi Parameswaran
Research 17 March 2026
Article: 158
Antimicrobial catheters coated with poly-L-lysine for the prevention of bacteriuria in adults requiring short-term catheterization: a multicenter randomized controlled trial
涂有聚-L-赖氨酸的抗菌导管预防短期导尿成人患者菌尿症：一项多中心随机对照试验
Xinfei LiJun LiuKai Zhang
Research 09 February 2026
Article: 157
Penpulimab in combination with lenalidomide and R-GemOx regimen (R2-GemOx-PD1i) in relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm, phase 2 trial
派安普利单抗联合来那度胺和R-GemOx方案（R2-GemOx-PD1i）治疗复发或难治性弥漫性大B细胞淋巴瘤：一项多中心、单臂、2期试验
Jin-Hua LiangTong-Yao XingWei Xu
Research 09 February 2026
Article: 156
Digital twin brain reveals state-specific stimulation targets for abnormal brain dynamics in tinnitus
数字孪生大脑揭示耳鸣异常脑动力学状态特异性刺激靶点
Jiaqi ZhangShuting HanTianzi Jiang
Research 10 February 2026
Article: 155
The case for mandatory reporting to enable targets for healthy and environmentally sustainable food: means, motive and opportunity
强制报告实现健康且环境可持续食物目标的理由：方法、动机和机会
Rachel PecheyLauren BandySusan A. Jebb
Debate 10 February 2026
Article: 154
Genetic insights into radiomic and proteomic changes under β1-blockers treatment in hypertensive heart disease and hypertrophic cardiomyopathy
β1受体阻滞剂治疗高血压性心脏病和肥厚型心肌病时放射组学和蛋白质组学变化的遗传学见解
Zhe ChenYifan TangKai Xie
Research 09 February 2026
Article: 153
Part of 1 collection:Cardiomyopathy and cardiac arrhythmias
所属专题合集：心肌病与心律失常
Optimizing drug-resistant tuberculosis diagnosis: cost-effectiveness of rapid molecular and phenotypic assays in South Africa
优化耐药结核病诊断：南非快速分子和表型检测方法的成本效益分析
Ginenus FekaduTadesse TolossaWai Kit Ming
Research 09 February 2026
Article: 152
Maternal smoking based on pre-birth health examination and risk of neurodevelopmental disorders in offspring: insights from a Korean mother–child cohort
基于产前健康检查探讨母亲吸烟与后代神经发育障碍风险的关系：来自韩国母婴队列研究的见解
Chan Soon ParkMoonyoung JangJun-Bean Park
Research 11 March 2026
Article: 151
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Effects of ablation versus drug therapy on clinical outcomes and quality of life by frailty status in atrial fibrillation: a post hoc analysis of the CABANA trial
根据衰弱状态分析消融术与药物治疗对心房颤动患者临床预后和生活质量的影响：CABANA试验的事后分析
Lili WangYanguang LiYunlong Wang
Research 07 February 2026
Article: 150
Part of 1 collection:Cardiomyopathy and cardiac arrhythmias
所属专题合集：心肌病与心律失常
Quantifying lifetime risk for 1,401 infectious diseases across the diabetes spectrum using a Bayesian approach
采用贝叶斯方法量化糖尿病全病程中1401种传染病的终生风险
Boomer B. OlsenMartin Tristani-FirouziEdgar Javier Hernandez
Research 07 February 2026
Article: 149
Part of 1 collection:Diabetes and infectious disease
所属专题合集：糖尿病与传染病
Risk assessment of asthma and allergic rhinitis in atopic dermatitis patients treated with biologics and JAK inhibitors: a systematic review and network meta-analysis of randomized controlled trials
对接受生物制剂和JAK抑制剂治疗的特应性皮炎患者罹患哮喘和过敏性鼻炎的风险评估：一项针对随机对照试验的系统综述和网络荟萃分析
Liling ZengTong ZhouJing Li
Research 07 February 2026
Article: 148
Preclinical activity of brincidofovir in peripheral T-cell and NK/T-cell lymphoma
布林西多福韦（brincidofovir）在外周T细胞和NK/T细胞淋巴瘤中的临床前活性
Jason Yongsheng ChanElizabeth Chun Yong LeeChoon Kiat Ong
Research 06 February 2026
Article: 147
Genetic risk factors modulate the association between physical activity and colorectal cancer
遗传风险因素调节身体活动与结直肠癌之间的关联
Anita R. PeoplesMireia Obón-SantacanaVictor Moreno
Research 05 February 2026
Article: 146
A neuroimaging biomarker for disease staging in clinically diagnosed Alzheimer’s disease
临床诊断阿尔茨海默病的疾病分期神经影像学标志物
Zhuangzhuang LiShaozhen YanYong Liu
Research 05 February 2026
Article: 145
Association of GLP-1 receptor agonists with herpes risks in diabetes mellitus: a target trial emulation
胰高血糖素样肽-1（GLP-1）受体激动剂与糖尿病中疱疹风险的关联：一项目标试验模拟研究
Chi-Hsien HuangI-Hui ChiangJames Cheng-Chung Wei
Research 31 December 2025
Article: 144
Part of 1 collection:Diabetes and infectious disease
所属专题合集：糖尿病与感染性疾病
Neoadjuvant immunochemotherapy plus thymalfasin in locally advanced gastric cancer: a prospective clinical trial
局部晚期胃癌联合胸腺肽的新辅助免疫化疗：一项前瞻性临床试验
Hao XuFengyuan LiZekuan Xu
Research 26 February 2026
Article: 143
Part of 1 collection:Clinical trials for gastrointestinal cancer
所属专题合集：胃肠道癌症的临床试验
Detection of sequelae from acute meningitis during clinical review by a healthcare provider: a systematic review and meta-analysis
临床医生在临床复查中检测急性脑膜炎后遗症：一项系统综述和荟萃分析
Luisa F. AlvizCarla Y. KimKiran T. Thakur
Research 28 February 2026
Article: 142
Part of 1 collection:Acute meningitis: a collection of systematic reviews
所属专题合集：急性脑膜炎：系统综述合集
ISG15-driven immune modulation and tumor progression in breast cancer metastasis: insights from single-cell and spatial transcriptomics
ISG15驱动的免疫调节与乳腺癌转移中的肿瘤进展：来自单细胞和空间转录组学的见解
Hua ShaoHanlu TangYongqing Xu
Research 04 February 2026
Article: 141
Evaluating the impact of family history and polygenic risk scores on cardiometabolic disease risk
评估家族史和多基因风险评分对心代谢疾病风险的影响
Ebuka OnyenobiKnightess OyiboSally N. Adebamowo
Research 03 February 2026
Article: 140
Social networking site use, depressive and anxiety symptoms in adolescents: evidence from a longitudinal cohort study (SCAMP)
社交网站使用与青少年抑郁和焦虑症状：来自纵向队列研究（SCAMP）的证据
Chen ShenBraulio M. Girela-SerranoMireille B. Toledano
Research 03 February 2026
Article: 139
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Early gestational prediction of spontaneous preterm birth using a validated three-protein serum biomarker panel
使用经验证的三蛋白血清生物标志物组合进行早孕期自发性早产预测
Qiong LuoJuan WeiXuefeng B. Ling
Research 02 February 2026
Article: 138
Household cannabis cessation and adolescent mental health outcomes in a prospective cohort study
一项前瞻性队列研究中家庭大麻戒断与青少年心理健康预后的关系
Ming WangYixiang XuFei Li
Research 02 February 2026
Article: 137
Part of 1 collection: Psychoactives: Recreational drugs repurposed as novel therapies
所属专题合集：精神活性物质：娱乐性药物重新利用为新型疗法
Objective assessment of long-term impact of COVID-19 on multiple sensory functions
客观评估新冠肺炎对多种感觉功能的长期影响
Ahmad OdehVeronica L. FormanekKai Zhao
Research 27 February 2026
Article: 136
Detection of hearing loss by formal audiological testing after acute infectious meningitis: a global systematic review and meta-analysis
急性感染性脑膜炎后通过正式听力检测诊断听力损失：一项全球系统综述和荟萃分析
Luisa F. AlvizCarla Y. KimKiran T. Thakur
Review 28 February 2026
Article: 135
Part of 1 collection: Acute meningitis: a collection of systematic reviews
所属专题合集：急性脑膜炎：系统综述合集
Serological evidence of substantial respiratory syncytial virus infection burden among older adults residing in Swedish long-term care facilities
血清学证据表明，居住在瑞典长期护理机构中的老年人存在沉重的呼吸道合胞病毒感染负担
Preeti MoarChristoffer GranvikMattias N. E. Forsell
Research 24 February 2026
Article: 134
Association of parental education with offspring psychiatric diagnoses, violent crimes, and suicidal behavior: a nationwide Swedish quasi-experimental study
父母受教育程度与后代精神疾病诊断、暴力犯罪和自杀行为之间的关联：一项瑞典全国范围的准实验研究
Mengping ZhouHenrik LarssonErik Pettersson
Research 26 February 2026
Article: 133
Discriminative performance of externally validated dementia risk prediction models: a systematic review and meta-analysis
外部验证的痴呆风险预测模型的鉴别性能：一项系统综述和荟萃分析
Blossom C. M. StephanJacob BrainMario Siervo
Research 02 February 2026
Article: 132
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian cancer: a phase 3, double-blind, parallel group, randomized controlled pilot study
静脉注射大剂量硒预防铂敏感复发性卵巢癌化疗所致周围神经病变的有效性和安全性：一项3期、双盲、平行组、随机对照试点研究
Ga Won YimKyung Hee HanHee Seung Kim
Research 02 February 2026
Article: 131
Time for change in implementation research and practice
实施研究和实践中变革的时机已到
Mike EnglishJacob McKnightSebastian Fuller
Debate 02 February 2026
Article: 130
CardioMetAge estimates cardiometabolic aging and predicts disease outcomes
CardioMetAge可评估心脏代谢年龄并预测疾病结局
Yucan LiXinming XuKelin Xu
Research 31 January 2026
Article: 129
Disproportionate climate burden of rising temperatures on low birth weight in Pakistan
气温上升给巴基斯坦低出生体重儿带来的不成比例的气候负担
Syeda H. FatimaCorey J. A. BradshawZohra S. Lassi
Research 31 January 2026
Article: 128
Part of 1 collection: Climate change and human health
所属专题：气候变化与人类健康
Enhancing oncolytic virotherapy with a tri-specific T-cell engager targeting CD3ε, EpCaM, and 4-1BB: preclinical evaluation and implications for cancer immunotherapy
利用靶向CD3ε、EpCaM和4-1BB的三特异性T细胞衔接器增强溶瘤病毒疗法：临床前评估及对癌症免疫疗法的启示
Zhongyi DongHaoyu ZhangZizhen Zhang
Research 30 January 2026
Article: 127
Targeting BCL-XL for degradation synergizes with gemcitabine against cholangiocarcinoma
靶向降解BCL-XL与吉西他滨联用对胆管癌具有协同治疗作用
Qinghua ZengYan ZhangYonghan He
Research 30 January 2026
Article: 126
Association of DNA methylation with hypertension and blood pressure: a 7-year longitudinal study from KORA F4/FF4
DNA甲基化与高血压及血压的关联：来自KORA F4/FF4的7年纵向研究
Liye LaiAngelina Shin Yee JongMelanie Waldenberger
Research 04 February 2026
Article: 125
Shared genetic architecture of psychoactive substance use and pan-cancer: insights from a large‑scale genome‑wide cross‑trait analysis
精神活性物质使用与泛癌症的共享遗传结构：来自大规模全基因组跨性状分析的见解
Jiahang SongPengzhu LiOlivier Gires
Research 05 February 2026
Article: 124
Part of 1 collection: Psychoactives: Recreational drugs repurposed as novel therapies
所属专题：精神活性物质：作为新型疗法的娱乐性药物再利用
Intrauterine exposure to maternal diabetes and the risk of developing epilepsy in children: a national cohort study of 2.3 million children
宫内暴露于母体糖尿病与儿童患癫痫风险的关系：一项针对230万儿童的全国队列研究
Muhammad Zakir HossinMartina PerssonNeda Razaz
Research 14 February 2026
Article: 123
ADHD and adherence to antihypertensive medication treatment: a multinational cohort study
多动症与坚持抗高血压药物治疗的关系：一项多国队列研究
Honghui YaoYiling ZhouZheng Chang
Research 20 February 2026
Article: 122
How effective is rejoining a long-term weight loss program? The 5- and 10-year MRI-assessed Follow Interventions Trial (FIT) project
重新加入长期减肥计划的效果如何？5年和10年磁共振成像评估的随访干预试验（FIT）项目
Hadar KleinDafna PachterIris Shai
Research 30 January 2026
Article: 121
Part of 1 collection: Weight loss interventions and their health impacts
所属专题：减肥干预措施及其对健康的影响
Correction: Brain state dynamics and working memory in patients with schizophrenia and unaffected siblings
更正：精神分裂症患者及其未受影响兄弟姐妹的脑状态动态与工作记忆
Feiwen WangJie YangLena Palaniyappan
Correction 20 February 2026
Article: 120
Ocular light and optical radiation exposure as a modifiable environmental determinant of health: expert consensus on research gaps and priorities
作为可改变的环境健康决定因素的眼睛光暴露和光学辐射暴露：关于研究空白和优先事项的专家共识
Manuel SpitschanAnna M. BillerJohannes Zauner
Guideline 29 January 2026
Article: 119
Dietary patterns and neuropsychological function in adolescents: a cross-sectional and longitudinal study
青少年饮食模式与神经心理功能：一项横断面和纵向研究
Alexios ManidisNicolas Ayala-AldanaJordi Julvez
Research 29 January 2026
Article: 118
Part of 1 collection: Child and adolescent psychiatry
所属专题：儿童与青少年精神病学
Factors impacting the delivery of contextualized care in serious illness: a focus group study with healthcare professionals
影响危重症患者情境化护理实施的因素：一项针对医疗保健专业人员的焦点小组研究
Linda ModderkolkYvonne SchoonAnne B. Wichmann
Research 29 January 2026
Article: 117
Part of 1 collection: Palliative care and medicine
所属专题：姑息治疗与医学
Early interventions for first onset of symptoms of mental health conditions: an umbrella review of systematic reviews
针对心理健康问题首次出现症状的早期干预措施：一项系统综述的伞式评价
Jasmine LeePhoebe BarnettSonia Johnson
Research 29 January 2026
Article: 116
Harmonic patterns embedded in ictal EEG signals in focal epilepsy: new insight into the epileptogenic zone
局灶性癫痫发作间期脑电图信号中嵌入的谐波模式：对致痫区的新见解
Lingli HuLingqi YeShuang Wang
Research 28 January 2026
Article: 115
Part of 1 collection: Epilepsy: Seizure prevention, treatment, and epidemiology
所属专题合集：癫痫：发作预防、治疗和流行病学
Effects of aerobic or resistance exercise on sleep and cancer-related fatigue in patients with breast cancer during or after neoadjuvant chemotherapy: a 3-arm randomized controlled trial
有氧运动或抗阻运动对新辅助化疗期间或之后乳腺癌患者睡眠和癌症相关疲劳的影响：一项三臂随机对照试验
Alexander HaussmannMartina E. SchmidtKaren Steindorf
Research 28 January 2026
Article: 114
Neutrophil methylmalonic acid promotes microthrombus formation and adverse cardiac remodeling post-myocardial infarction through activating IL-6 signaling pathway-mediated NETosis
中性粒细胞甲基丙二酸通过激活IL-6信号通路介导的中性粒细胞胞外诱捕网形成（NETosis），促进心肌梗死后微血栓形成和不良心脏重构
Yige LiuJiaxin WangShaohong Fang
Research 28 January 2026
Article: 113
Statistical approaches to analyse the combined effect of seven air pollutants and breast cancer risk: a case–control study nested in the French E3N-Generations cohort
分析七种空气污染物联合作用与乳腺癌风险关系的统计方法：一项嵌套于法国E3N-Generations队列的病例对照研究
Camille GiampiccoloBéatrice FerversAmina Amadou
Research 28 January 2026
Article: 112
Part of 1 collection: Carcinogens and human health
所属专题合集：致癌物与人类健康
Is behaviour change communication guidance for general practice healthcare professionals evidence based? A systematic review
针对全科医疗保健专业人员的行为改变沟通指导是否具有循证依据？一项系统综述
Anika Schwarze-ChintapatlaJonathan Livingstone-BanksCharlotte Albury
Research 16 February 2026
Article: 111
Patient-centred postpartum care provision: virtual delivery, tiered escalation, and tensions between efficiency, preference, and clinical concern
以患者为中心的产后护理服务提供：虚拟服务模式、分级转诊机制，以及效率、患者偏好与临床关切之间的矛盾
Sergio A. SilverioJulia R. B. BrownEmma L. Duncan
Research 24 February 2026
Article: 110
Ethical dilemmas in climate change and healthcare delivery: a cross-sectional survey of US patient perspectives
气候变化与医疗服务中的伦理困境：一项针对美国患者观点的横断面调查
Andrew HantelEmily SenayGregory A. Abel
Research 27 January 2026
Article: 109
Part of 1 collection: Climate change and human health
所属专题：气候变化与人类健康
Inetetamab plus camrelizumab and utidelone for pretreated HER2-positive advanced breast cancer: a prospective, single-arm, phase 2 study
伊尼妥单抗联合卡瑞利珠单抗和优替德隆治疗既往接受过治疗的HER2阳性晚期乳腺癌：一项前瞻性、单臂、2期研究
Huimin LvTao SunMin Yan
Research 27 January 2026
Article: 108
Potential of earlier primary care health checks for prevention of cardiovascular events in younger age groups: population-based study in the United Kingdom
早期初级保健健康检查对预防年轻人群心血管事件的潜力：英国一项基于人群的研究
Catherine A. ScottLinxin LiPeter M. Rothwell
Research 24 January 2026
Article: 107
Comparative effects of salt substitutes on blood pressure, cardiovascular events and mortality: a systematic review and network meta-analysis
盐替代品对血压、心血管事件和死亡率影响的比较：一项系统综述和网络荟萃分析
Honghao LaiGihad NesrallahBradley C. Johnston
Research 23 January 2026
Article: 106
Association of short-term exposure to ambient air pollutants with liver function and mediation by fasting insulin: evidence from a rural cohort in China
短期暴露于环境空气污染物与肝功能的关系及空腹胰岛素的中介作用：来自中国农村队列研究的证据
Mengxin WangAogang ZhangWeidong Wu
Research 23 January 2026
Article: 105
Part of 1 collection:Climate change and human health
所属专题：气候变化与人类健康
Adjuvant tislelizumab, lenvatinib, and capecitabine for resected biliary tract cancer: a prospective phase II trial
辅助治疗：替雷利珠单抗、仑伐替尼和卡培他滨用于可切除的胆道癌：一项前瞻性II期试验
Yun FengNing ZhangLu Wang
Research 23 January 2026
Article: 104
Comparative effectiveness of sleeve gastrectomy and semaglutide for weight loss and metabolic outcomes: a prospective non-randomized study
袖状胃切除术与司美格鲁肽对减重及代谢结局的疗效比较：一项前瞻性非随机研究
Yutung YenQian ZhangYi Chen
Research 22 January 2026
Article: 103
Part of 1 collection:Weight loss interventions and their health impacts
所属专题：减重干预措施及其对健康的影响
Impact of sex on outcomes in patients treated with drug-coated balloons versus drug-eluting stents for de novo coronary artery lesions: Insights from the REC-CAGEFREE I trial
性别对接受药物涂层球囊与药物洗脱支架治疗的新发冠状动脉病变患者预后的影响：来自REC-CAGEFREE I试验的见解
Ping WangJingyu ZhouLing Tao
Research 22 January 2026
Article: 102
Assessing the comorbidity between asthma and depression through polygenic risk scoring and time-to-event models
通过多基因风险评分和时间事件模型评估哮喘与抑郁的共病情况
Xueting WangJun HeRenato Polimanti
Research 22 January 2026
Article: 101
Persistent immune, coagulation and cardiac dysregulation are correlated with later post-discharge mortality in children with severe malnutrition
严重营养不良儿童出院后持续存在的免疫、凝血和心脏功能失调与后期死亡率相关
Brenda KamauEvans O. MudiboJames M. Njunge
Research 22 January 2026
Article: 100
Correction: Computer assisted verbal autopsy: comparing large language models to physicians for assigning causes to 6939 deaths in Sierra Leone from 2019–2022
更正：计算机辅助口头尸检：对比大型语言模型与医生为2019 - 2022年塞拉利昂6939例死亡分配病因的情况
Richard WenAnteneh Tesfaye AssalifRashid Ansumana
Correction 14 February 2026
Article: 99
Characteristics of parks associated with depression in women only: a cross-sectional study of 329,363 adults
仅与女性抑郁相关的公园特征：一项针对329,363名成年人的横断面研究
Jonathan R. OlsenNatalie NichollsRichard Mitchell
Research 21 January 2026
Article: 98
Weight change mediates the effect of lifestyle intervention on postpartum diabetes in women with prior gestational diabetes: a secondary analysis of a randomized clinical trial
在生活方式干预对既往妊娠期糖尿病女性产后糖尿病影响中，体重变化的中介作用：一项随机临床试验的二次分析
Weiqin LiHuikun LiuGang Hu
Research 21 January 2026
Article: 97
Part of 1 collection: Diagnosis and management of gestational diabetes
所属专题：妊娠期糖尿病的诊断与治疗
Global drivers of heart failure attributable to atrial fibrillation/flutter: insights fromJoinpoint regression, age-period-cohort analysis, and future projections from the GBD 2021 Study
心房颤动/扑动所致心力衰竭的全球驱动因素：来自折点回归、年龄-时期-队列分析以及2021年GBD（全球疾病负担）研究未来预测的见解
Jing ChenZhu LiGregory Y. H. Lip
Research 20 January 2026
Article: 96
Part of 1 collection: Cardiomyopathy and cardiac arrhythmias
所属专题：心肌病与心律失常
Overdiagnosis of gestational diabetes mellitus during Ramadan: a retrospective population-based study in Catalonia, Spain
斋月期间妊娠期糖尿病的过度诊断：西班牙加泰罗尼亚地区一项基于人群的回顾性研究
Marta CarrascoBogdan VlachoMarta Hernández
Research 20 January 2026
Article: 95
Part of 1 collection: Diagnosis and management of gestational diabetes
所属专题：妊娠期糖尿病的诊断与管理
Why current risk factor-based approaches fall short in predicting stillbirth: a national cohort study of nulliparous women in England
为何当前基于风险因素的方法在预测死胎方面存在不足：英格兰初产妇全国队列研究
A. HowellB. ThilaganathanTommy’s National Centre for Maternity Improvement
Research 22 January 2026
Article: 94
Pay-it-forward intervention increased pneumococcal vaccine uptake among older adults in China: a randomized controlled trial
爱心传递干预措施提高了中国老年人肺炎球菌疫苗的接种率：一项随机对照试验
Jiao QinChunxing TaoBingyu Liang
Research 19 January 2026
Article: 93
The impact of e-cigarette taxation: a systematic review and meta-analysis on usage, pricing strategies, and public health implications
电子烟税收的影响：针对使用情况、定价策略和公共卫生影响开展的系统综述和荟萃分析
Quan WangZheng ZhuLi Yang
Research 17 January 2026
Article: 92
Safety and preliminary efficacy results of IBI389, an anti-Claudin18.2×CD3 bispecific antibody, in patients with solid tumors and gastric or gastro-esophageal tumors: a phase 1 dose escalation and expansion study
抗Claudin18.2×CD3双特异性抗体IBI389在实体瘤及胃或胃食管肿瘤患者中的安全性与初步疗效结果：一项1期剂量递增与扩展研究
Xiaoyu LiRuihong DaiFeng Bi
Research 16 January 2026
Article: 91
Part of 1 collection: Clinical trials for gastrointestinal cancer
所属专题：胃肠道癌症临床试验
Comparative risk of delirium among opioid users for non-cancer pain: a retrospective cohort study
比较非癌症疼痛使用阿片类药物者发生谵妄的风险：一项回顾性队列研究
Carlos Raul Ramirez MedinaMark LuntMeghna Jani
Research 31 January 2026
Article: 90
Association between preoperative interruption of antiplatelet therapy and postoperative thrombotic risk after minimally invasive surgery for abdominopelvic cancer in patients treated with P2Y12 inhibitors
接受P2Y12抑制剂治疗的患者行腹部盆腔癌症微创手术时，术前中断抗血小板治疗与术后血栓形成风险之间的关联
Masashi KubotaSatomi YoshidaKoji Kawakami
Research 16 January 2026
Article: 89
Comparative outcomes of distal ureterectomy vs. radical nephroureterectomy in high-risk distal ureteral urothelial carcinoma: a two-center cohort study in Northern and Southern China
高危远端输尿管尿路上皮癌患者行远端输尿管切除术与根治性肾输尿管切除术的疗效比较：中国北方和南方两家中心的队列研究
Junyi XieZhenhua LiuWei Yu
Research 16 January 2026
Article: 88
Co-occurrence patterns and related risk factors of dementia and Parkinson’s disease among older adults across 204 countries and territories: a spatial correspondence and systematic analysis
204个国家和地区老年人痴呆症与帕金森病共现模式及相关危险因素：空间对应与系统分析
Weiyang ChenMin DuJue Liu
Research 15 January 2026
Article: 87
Accelerated brain aging in amyotrophic lateral sclerosis and its prognostic associations: a cohort study
肌萎缩侧索硬化症加速脑衰老及其预后关联：一项队列研究
Chenhao FangJiaoting JinShuoqiu Gan
Research 15 January 2026
Article: 86
Part of 1 collection: Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题：肌萎缩侧索硬化症：最新进展与新动态
The clinical effects and cortical mechanism of rTMS in poststroke lateropulsion: a randomized controlled trial
重复经颅磁刺激（rTMS）对脑卒中后侧方倾倒的临床效果及皮质机制：一项随机对照试验
Lijiao MengRaymond C. C. TsangQuan Wei
Research 14 January 2026
Article: 85
5-HT2C receptors in the glutamatergic neurons of dorsal raphe nucleus orchestrate the comorbidity of pain and anxiety in mice
中脑背侧缝际核谷氨酸能神经元中的5-HT2C受体调控小鼠疼痛与焦虑共病
Qi ZhangLi XieRiyue Jiang
Research 13 January 2026
Article: 84
The clinical landscape of POLE-mutant colorectal cancer: a retrospective analysis of real-world outcome
POLE突变型结直肠癌的临床现状：一项现实结局的回顾性分析
Ting XuXuhui ZhangJian Li
Research 13 January 2026
Article: 83
The efficacy and safety of duloxetine in treating refractory chronic cough: a randomized clinical trial
度洛西汀治疗难治性慢性咳嗽的有效性和安全性：一项随机临床试验
Shengyuan WangHeng WuXianghuai Xu
Research 13 January 2026
Article: 82
Impact of diagnosis to ablation time on clinical outcomes in patients with atrial fibrillation: post hoc analysis of the CABANA trial
心房颤动患者从诊断到消融的时间对临床预后的影响：CABANA试验的事后分析
Manlin ZhaoYang ChenGregory Y. H. Lip
Research 12 January 2026
Article: 81
Part of 1 collection: Cardiomyopathy and cardiac arrhythmias
所属专题：心肌病与心律失常
Elevated maternal pre-transfer serum lipid peroxidation is associated with implantation failure and early pregnancy loss
母体转运前血清脂质过氧化水平升高与着床失败和早期流产相关
Zhangwei JiaJunxiang RenJunhao Yan
Research 12 January 2026
Article: 80
Impact of Helicobacter pylori infection on gut and intratumoral microbiome and its association with immunotherapy response in gastrointestinal cancer
幽门螺杆菌感染对肠道和肿瘤内微生物组的影响及其与胃肠道癌症免疫治疗反应的关联
Keren JiaYang ChenLin Shen
Research 12 January 2026
Article: 79
Part of 1 collection: Gut microbiota: New treatments of human disease
所属专题：肠道微生物组：人类疾病的新疗法
SGLT-2 Inhibitor use and liver-related and mortality outcomes in patients with type 2 diabetes and compensated cirrhosis
SGLT-2抑制剂在2型糖尿病合并代偿性肝硬化患者中的应用及其对肝脏相关预后和死亡率的影响
Tien-Shin ChouDaniel Hsiang-Te TsaiEdward Chia-Cheng Lai
Research 12 January 2026
Article: 78
Extrapolating from trials to clinic: a predictive model defining the boundaries of benefit for multiple sclerosis therapies in real-world populations based on systematic review
从试验外推至临床：基于系统综述构建预测模型，界定多发性硬化症疗法在现实人群中的获益边界
Bibiana BielekovaTianxia WuMichael Calcagni
Research 10 January 2026
Article: 77
A validated model for early prediction of group A streptococcal aetiology in necrotising soft tissue infections using minimal patient data
利用最少患者数据早期预测坏死性软组织感染A组链球菌病因的验证模型
Sonja KatzJaco SuijkerEdoardo Saccenti
Research 10 January 2026
Article: 76
Trends in lipid-lowering therapies in acute coronary syndromes after Chinese new insurance policy: a real-world analysis
中国新医保政策实施后急性冠状动脉综合征患者降脂治疗趋势：一项现实情况分析
Xin ZhaoShujing WuJunbo Ge
Research 09 January 2026
Article: 75
Fragmented healthcare and effective maternal coverage in Mexico, 2009–2023
2009-2023年墨西哥医疗体系碎片化与有效孕产妇医疗保障
Edson Serván-MoriDiego Cerecero-GarcíaOctavio Gómez-Dantés
Research 09 January 2026
Article: 74
Circadian rhythm disruption in cardiovascular disease: a systematic review and meta-analysis of mechanistic evidence from animal models
昼夜节律紊乱与心血管疾病：基于动物模型机制证据的系统综述与荟萃分析
Mrinal K. DasEvi De RyckJohanna Samulin Erdem
Research 09 January 2026
Article: 73
Frailty progression: The role of multimorbidity configurations in frailty transitions and predicting mortality risk among older adults
衰弱进展：多重共病组合模式在老年人衰弱状态转变及死亡风险预测中的作用
Rafael Ogaz-GonzálezQian ZouEva Corpeleijn
Research 08 January 2026
Article: 72
Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学及风险因素的作用
Effect of probiotic supplementation on the gut microbiota diversity in healthy populations: a systematic review and meta-analysis of randomised controlled trials
益生菌补充剂对健康人群肠道微生物群多样性的影响：一项针对随机对照试验的系统综述和荟萃分析
Anna Júlia ÉliásKincső Csepke Földvári-NagyLászló Földvári-Nagy
Research 07 January 2026
Article: 71
Part of 1 collection: Gut microbiota: New treatments of human disease
所属专题：肠道微生物群：人类疾病的新疗法
Pain and high-impact pain in community-dwelling older adults in Australia and relation to sociodemographic and health-related factors, including physical disability, psychological distress, and quality of life
澳大利亚社区居住老年人的疼痛及重度疼痛情况，及其与社会人口统计学因素和健康相关因素（包括身体残疾、心理困扰和生活质量）的关系
Grace JoshySaman Khalatbari-SoltaniEmily Banks
Research 22 January 2026
Article: 70
Mortality and morbidity burden associated with smoking: evidence from a 1.6 million cohort in Hong Kong
与吸烟相关的死亡率和发病率负担：来自香港160万人队列研究的证据
Boyuan WangTingting ChenEric Yuk Fai Wan
Research 06 January 2026
Article: 69
Part of 1 collection:Carcinogens and human health
所属专题：致癌物与人类健康
Association between long-term extreme high temperature and mortality: a 9-million prospective cohort study
长期极端高温与死亡率之间的关系：一项900万人的前瞻性队列研究
Bo YinQi HuangKuiying Gu
Research 06 January 2026
Article: 68
Part of 1 collection:Climate change and human health
所属专题：气候变化与人类健康
Unraveling the neurotoxic mechanisms of tranexamic acid in epilepsy induction: a network toxicology and molecular docking approach
利用网络毒理学和分子对接方法揭示氨甲环酸诱发癫痫的神经毒性机制
Tianyang ChenDalong LiuXiangYang Leng
Research 03 January 2026
Article: 67
Part of 1 collection: Epilepsy: Seizure prevention, treatment, and epidemiology
所属专题：癫痫：癫痫发作的预防、治疗和流行病学
Trop2 immuno-PET/CT imaging of prostate cancer: a proof-of-concept translational study
Trop2免疫正电子发射断层扫描/计算机断层扫描（PET/CT）成像在前列腺癌中的应用：一项概念验证性转化研究
Xingru LongShuxian AnDawei Jiang
Research 31 December 2025
Article: 66
Methylmalonate accumulation contributes to myocardial vulnerability post-reperfusion: a novel therapeutic target and prognostic biomarker
甲基丙二酸蓄积促进再灌注后心肌脆弱性：一种新型治疗靶点和预后生物标志物
Shanjie WangJunChen GuoShaohong Fang
Research 31 December 2025
Article: 65
Prophylactic effect of intraoperative sodium oxybate on postoperative delirium in older patients undergoing major orthopedic surgery: a randomized clinical trial
术中羟丁酸钠对接受大型骨科手术的老年患者术后谵妄的预防作用：一项随机临床试验
Meiying CuiHang XuePing Zhao
Research 31 December 2025
Article: 64
Part of 1 collection:Psychoactives: Recreational drugs repurposed as novel therapies
所属专题：精神活性物质：将娱乐性药物重新用于新型疗法
Prevalence of hysterectomy in urban China and associations between metabolic disorders and hysterectomy: a multicenter population-based study involving over 9 million women
中国城市子宫切除术的流行情况以及代谢紊乱与子宫切除术之间的关系：一项涉及超过900万女性的多中心人群基础研究
Yanrui BiYuan MaYing Gao
Research 30 December 2025
Article: 63
Sex differences in cardiac risk and kidney function: serum creatinine versus cystatin C
心脏风险和肾功能方面的性别差异：血清肌酐与胱抑素C的对比
Nicole L. De La MataJames A. HedleyJennifer S. Lees
Research 30 December 2025
Article: 62
The association of post-conization pregnancy with subsequent cervical lesions: evidence from a nationwide cohort in Sweden
锥切术后妊娠与后续宫颈病变的关联：来自瑞典全国队列研究的证据
Huan YiJimiao HuangJianguang Ji
Research 29 December 2025
Article: 61
Tibial periosteal distraction for ischemic leg ulcers: animal and clinical cohort study
胫骨骨膜牵张术治疗缺血性下肢溃疡：动物及临床队列研究
Peilin ZhouWenqiang WangQikai Hua
Research 28 December 2025
Article: 60
Preoperative conversion therapy of camrelizumab combined with paclitaxel and nedaplatin for unresectable advanced esophageal squamous cell carcinoma: a phase 2 study
卡瑞利珠单抗联合紫杉醇和奈达铂对不可切除的晚期食管鳞癌的术前转化治疗：一项2期研究
Jinhong ZhuJinfeng ZhangJianqun Ma
Research 28 December 2025
Article: 59
Clustering of cardiometabolic risk factors, physical activity, digital exclusion, and depressive symptoms trajectories in adults aged 50years and older: findings from two prospective cohort studies
50岁及以上成年人心血管代谢风险因素聚集、身体活动、数字排斥及抑郁症状轨迹：两项前瞻性队列研究的发现
Xiaosheng DongJiaqiang XiaoChengchao Zhou
Research 28 December 2025
Article: 58
Eligibility of real-world patients for aspirin primary prevention trials in cardiovascular disease
现实中符合心血管疾病阿司匹林一级预防试验资格的患者情况
Michael HolderDaniel R. MoralesBruce Guthrie
Research 27 January 2026
Article: 57
Polygenic risk score-guided personalized osteoporosis screening: a population-based study
基于多基因风险评分指导的个性化骨质疏松症筛查：一项基于人群的研究
Dongxue WangWen SunJianguang Ji
Research 14 January 2026
Article: 56
Urea cycle modulation by combined SGLT2 inhibitors and metformin
SGLT2抑制剂与二甲双胍联合用药对尿素循环的调节作用
Makoto HaradaJonathan AdamRui Wang-Sattler
Research 08 January 2026
Article: 55
Safety and neuroprotective efficacy of the VCP inhibitor ML240 in large-animal and human retinal explants: a preclinical ex vivo study
VCP抑制剂ML240在大型动物及人视网膜外植体中的安全性和神经保护功效：一项临床前离体研究
Ana-Cristina Almansa-GarcíaAngela ArmentoBlanca Arango-Gonzalez
Research 10 January 2026
Article: 54
Impact of an eight-week isocaloric vegan dietary intervention on hemogram parameters and lymphocyte subsets: a randomized-controlled trial
为期八周的等热量纯素饮食干预对血细胞参数和淋巴细胞亚群的影响：一项随机对照试验
Julian HerterFrieda StübingMaximilian Andreas Storz
Research 10 January 2026
Article: 53
Association between psychosocial factors and adverse effects of light-to-moderate ambient heat in patients with chronic diseases: results of the prospective cohort study CLIMATE-II
社会心理因素与轻至中度环境热对慢性病患者不良影响之间的关联：前瞻性队列研究CLIMATE-II的结果
Ingmar SchäferValentina PauckeDagmar Lühmann
Research 15 January 2026
Article: 52
Part of 1 collection:Climate change and human health
所属专题：气候变化与人类健康
Maternal infection during pregnancy and the risk of childhood cancer: a systematic review and meta-analysis
孕期母体感染与儿童期患癌风险：一项系统综述和荟萃分析
Loviisa MulanjeLara Kim BrackmannRajini Nagrani
Research 14 January 2026
Article: 51
Part of 1 collection:Carcinogens and human health
所属专题：致癌物与人类健康
Supplementary biomarker testing in molecular tumor boards increases actionable therapy recommendations: a prospective real-world study of 658 patients
分子肿瘤委员会中的补充生物标志物检测增加了可采取治疗措施的建议：一项针对658例患者的前瞻性真实世界研究
Alexander ScheiterSimon MellinKirsten Utpatel
Research 14 January 2026
Article: 50
Computer assisted verbal autopsy: comparing large language models to physicians for assigning causes to 6939 deaths in Sierra Leone from 2019–2022
计算机辅助口头尸检：对比大型语言模型与医生对塞拉利昂2019 - 2022年6939例死亡原因的判定
Richard WenAnteneh Tesfaye AssalifRashid Ansumana
Research 24 December 2025
Article: 49
Loss of Y chromosome and its implications in male amyotrophic lateral sclerosis: insights from the UK Biobank
Y染色体缺失及其在男性肌萎缩侧索硬化症中的影响：来自英国生物银行的研究见解
Wei-Ming SuQing-Qing DuanYong-Ping Chen
Research 24 December 2025
Article: 48
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题：肌萎缩侧索硬化症：最新进展与新动态
Prenatal lipopolysaccharide exposure programs the early-life lung development by modulating mesenchymal fibroblasts in a time- and dose-dependent manner
产前脂多糖暴露通过调节间充质成纤维细胞以时间和剂量依赖性方式来影响早期肺部发育
Ying DongStefan HadzicSaverio Bellusci
Research 22 December 2025
Article: 47
Life course socioeconomic trajectories and chronic disease risk in later life among 30,055 older adults across 27 European countries (the SHARE study)
27个欧洲国家30,055名老年人生命历程中的社会经济轨迹与晚年慢性疾病风险（基于SHARE研究）
Taymara C. AbreuJoline W. J. BeulensJoreintje D. Mackenbach
Research 20 December 2025
Article: 46
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学与风险因素的作用
Validation of a novel patient-reported measure of the burden of digital care in diabetes
由糖尿病患者报告的数字化护理负担新型测评工具的验证
Misk Al ZahidyJennifer L. RidgewayVictor M. Montori
Research 20 December 2025
Article: 45
Determinants of long-term SARS-CoV-2 immune responses in asymptomatic-to-moderate COVID-19 patients in sub-Saharan Africa
撒哈拉以南非洲地区无症状至中度 COVID-19 患者长期 SARS-CoV-2 免疫应答的决定因素
Víctor L. de RiojaOdin GoovaertsGemma Moncunill
Research 14 January 2026
Article: 44
Camrelizumab and apatinib in Chinese patients with locally advanced or metastatic radioiodine-refractory differentiated thyroid cancer: an exploratory open-label, single-arm trial
卡瑞利珠单抗联合阿帕替尼治疗中国局灶性晚期或转移性放射性碘难治性分化型甲状腺癌：一项探索性开放标签单臂试验
Xin ZhangDi SunYansong Lin
Research 18 December 2025
Article: 43
Urinary polyphenol signature of the Mediterranean diet is associated with lower cardiovascular disease risk: the PREDIMED trial
地中海饮食的尿液多酚特征与心血管疾病风险较低相关：PREDIMED 试验
Inés Domínguez-LópezPolina GalkinaRosa M. Lamuela-Raventós
Research 18 December 2025
Article: 42
Meta-analysis and external validation of a risk model for gastrointestinal bleeding after percutaneous coronary intervention
经皮冠状动脉介入治疗后胃肠道出血风险模型的荟萃分析及外部验证
Hualong MaCong PengQiaohong Yang
Research 18 December 2025
Article: 41
DNA methylation-based clocks, tobacco smoking, and lung cancer risk
基于DNA甲基化的生物钟、烟草吸烟与肺癌风险
Ricardo Cortez Cardoso PenhaJustina Ucheojor OnwukaMattias Johansson
Research 17 December 2025
Article: 40
Part of 1 collection:Carcinogens and human health
所属专题：致癌物与人类健康
Risk and protective factors associated with brain grey matter patterns in a population-based cohort of cognitively unimpaired 70years old
认知功能未受损的70岁老年人基于人口的队列中，与大脑灰质模式相关的风险和保护因素
Giulia LorenzonAnna MarsegliaEric Westman
Research 17 December 2025
Article: 39
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学和风险因素的作用
Street view-derived city built environment and vulnerability to temperature extremes: a nationally representative population-based cohort study
基于街景图像的城市建成环境与极端温度脆弱性：一项全国代表性人口队列研究
Wanzhou WangChao YangLuxia Zhang
Research 16 December 2025
Article: 38
Part of 1 collection:Climate change and human health
所属专题：气候变化与人类健康
A booster dose of an inactivated SARS-CoV-2 vaccine targeting virus variants sustains protective humoral and cellular immunity
针对病毒变异株的灭活严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）疫苗加强针可维持保护性体液免疫和细胞免疫
Constanza MéndezLinmar Rodríguez-GuilarteSusan M. Bueno
Research 15 December 2025
Article: 37
Dapagliflozin alleviates sunitinib-induced cardiotoxicity through AMPKα-PPARα axis and enhances the sensitivity of renal cell carcinoma to sunitinib
达格列净通过AMPKα-PPARα轴减轻舒尼替尼诱导的心脏毒性，并增强肾细胞癌对舒尼替尼的敏感性
Shi-yu HuangMin HuLei Wang
Research 15 December 2025
Article: 36
Network dysfunction underlying verbal fluency deficits in newly diagnosed epilepsy: a resting-state fMRI functional connectivity study
新诊断癫痫患者言语流畅性缺陷背后的网络功能障碍：一项静息态功能磁共振成像功能连接研究
Fangzhou LiuPing JiangLing Liu
Research 13 December 2025
Article: 35
Part of 1 collection:Epilepsy: Seizure prevention, treatment, and epidemiology
所属专题：癫痫：癫痫发作的预防、治疗和流行病学
Long-term quality of life in non-epithelial ovarian cancer survivors: TMRG-GINECO-Vivrovaire rare tumors case–control study
基于广西新生儿地中海贫血基因组图谱计划开展的家庭三联体/四联体分析
Coraline DubotIsabelle Ray-CoquardFlorence Joly
Research 12 December 2025
Article: 34
Family trios/quartets analysis based on the Newborn Genomic Atlas for Thalassemia project in Guangxi
非上皮性卵巢癌幸存者的长期生活质量：TMRG-GINECO-Vivrovaire罕见肿瘤病例对照研究
Wei WeiChunrong GuiBaoheng Gui
Research 12 December 2025
Article: 33
Hyperuricemic persons use more analgesics than normouricemic—is asymptomatic hyperuricemia really asymptomatic?
高尿酸血症患者比血尿酸正常者使用更多镇痛药——无症状性高尿酸血症真的“无症状”吗？
Janis TimsansJenni Emilia KauppiMarkku Kauppi
Research 11 December 2025
Article: 32
Social isolation, loneliness, and multi-system medical conditions: phenome-wide association and disease-trajectory analyses
社会孤立、孤独感与多系统医学病症：全表型组关联分析及疾病轨迹研究
Tingshan DuanZhi CaoChenjie Xu
Research 10 December 2025
Article: 31
Digital marketing techniques within online food retail platforms: a scoping review
在线食品零售平台中的数字营销技巧：一项范围综述
Adyya GuptaCatherine E. HugginsAnna Peeters
Research 10 December 2025
Article: 30
Dramatic increases in redundant publications in the Generative AI era
生成式人工智能时代冗余出版物数量急剧增加
Danny MaupinTulsi SuchakMatt Spick
Research 09 December 2025
Article: 29
Cardiovascular risk burden and guideline-recommended lipid and blood pressure goals in an Italian Cohort: findings from the HUMTELEMED web-based platform
意大利人群心血管风险负担及指南推荐的血脂和血压目标达成情况：HUMTELEMED网络平台的发现
Matteo LandolfoAlessandro GezziRiccardo Sarzani
Research 09 December 2025
Article: 28
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学及风险因素的作用
Efficacy and safety of Janus kinase 1/2 inhibitor KL130008 in active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase II trial
Janus激酶1/2抑制剂KL130008治疗活动性类风湿关节炎的有效性和安全性：一项随机、双盲、安慰剂对照的II期试验
Yue ChengHonghu TangYi Liu
Research 09 December 2025
Article: 27
Risk stratification for endometrial cancer: independent and joint effects of polygenic risk score and body mass index in 129,829 UK Biobank participants
子宫内膜癌的风险分层：英国生物银行129,829名参与者中多基因风险评分和体重指数的独立及联合效应
Xuemin WangLaure DossusTracy A. O’Mara
Research 10 February 2026
Article: 26
Maternal probiotics intake during pregnancy and exclusive colostrum breastfeeding are associated with a reduced risk of neonatal jaundice
孕期摄入益生菌及纯母乳喂养初乳与新生儿黄疸风险降低相关
Bekalu Kassie AlemuChi Chiu WangYao Wang
Research 08 December 2025
Article: 25
Hepatic steatosis in postmenopausal women is characterized by distinct serum extracellular vesicle proteomic signatures
绝经后女性脂肪肝具有独特的血清细胞外囊泡蛋白质组特征
Patrick PirrotteBrooke LovellJohanna K. DiStefano
Research 07 December 2025
Article: 24
Global, regional, and national temporal trends in the prevalence of environmental heat and cold exposure among older adults aged 60–99 years, 1990–2021: an age-period-cohort analysis based on the Global Burden of Disease Study 2021
基于2021年全球疾病负担研究，对1990 - 2021年60 - 99岁老年人环境热暴露和冷暴露患病率的全球、区域和国家时间趋势分析：一项基于年龄 - 时期 - 队列模型的分析
Shenghao XuJing WangJianlin Xiao
Research 07 December 2025
Article: 23
Part of 1 collection:Climate change and human health
所属专题：气候变化与人类健康
Cyclophilin B deficiency enhances myocardial energy synthesis and protects against heart failure in preclinical models
亲环蛋白B缺乏可增强心肌能量合成，并在临床前模型中预防心力衰竭
Xiao ZongXierenayi TudiRong Tao
Research 07 December 2025
Article: 22
Part of 1 collection:Cardiomyopathy and cardiac arrhythmias
所属专题：心肌病与心律失常
Normobaric hyperoxia for intracerebral hemorrhage: a randomized clinical trial
常压高氧治疗脑出血：一项随机临床试验
Zhiying ChenJiayue DingRan Meng
Research 07 December 2025
Article: 21
Nationwide trends in pediatric hospitalizations for eating disorders in France between 2013 and 2022: a retrospective study using the national health insurance database
Emmanuelle LogeaisFrançoise TroussierLilia Khendek
2013 - 2022年法国因进食障碍住院的儿科患者全国趋势：一项使用国家健康保险数据库的回顾性研究
Research 05 December 2025
Article: 20
Part of 1 collection:Child and adolescent psychiatry
所属专题：儿童与青少年精神病学
Self-management of vaginal pessaries for pelvic organ prolapse: multi-method process evaluation, linked to the TOPSY randomised controlled trial
盆腔器官脱垂阴道子宫托自我管理：与TOPSY随机对照试验相关的多方法过程评估
Carol BuggeMelanie Dembinskythe TOPSY team
Research 05 December 2025
Article: 19
Large-scale plasma proteomics reveals bidirectional associations between sleep patterns and inflammatory bowel disease: a prospective cohort study
大规模血浆蛋白质组学研究揭示睡眠模式与炎症性肠病之间的双向关联：一项前瞻性队列研究
Kaixing LeYaru LiuZhigang Liu
Research 05 December 2025
Article: 18
Association between socioeconomic status and diabetic retinopathy in individuals with type 1 diabetes: a systematic review and meta-analysis
1型糖尿病患者社会经济地位与糖尿病视网膜病变之间的关联：一项系统综述和荟萃分析
Fernando Sebastian-VallesSergio Núñez de Arenas-ArroyoJulia Martínez-Alfonso
Review 05 December 2025
Article: 17
Patterns of disparity: age and socioeconomic differences in women’s smoking and quitting outcomes in Great Britain
差异模式：英国女性吸烟及戒烟结局的年龄和社会经济差异
Sarah E. JacksonCaitlin NotleySharon Cox
Research 10 February 2026
Article: 16
Genomic pathogenic alterations in the SWI/SNF complex compromise the outcomes of immunotherapy in Chinese patients with KRAS-mutant NSCLC by downregulating STING expression
SWI/SNF复合体中的基因组致病性改变通过下调STING表达损害中国KRAS突变型非小细胞肺癌患者的免疫治疗效果
Lingling GaoJie JiangXuchao Zhang
Research 03 December 2025
Article: 15
Residential radon exposure and incident myocardial infarction and stroke risks in the All of Us Research Program
“我们所有人”研究项目中住宅氡暴露与心肌梗死和卒中发病风险的关系
Jiajun LuoZhihao JinBriseis Aschebrook-Kilfoy
Research 03 December 2025
Article: 14
Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet and cardiovascular disease and arrhythmias
用于延缓神经退行性变的地中海饮食-终止高血压膳食疗法干预措施（MIND）与心血管疾病及心律失常的关系
Pei QinFrederick K. HoJill P. Pell
Research02 December 2025
Article: 13
Part of 1 collection: Cardiomyopathy and cardiac arrhythmias
所属专题：心肌病与心律失常
KoMethylNet: a novel epigenetic clock based on neural network analysis of DNA methylation data and epigenetic age acceleration in a Korean population
KoMethylNet：基于神经网络分析DNA甲基化数据的新型表观遗传时钟及韩国人群的表观遗传年龄加速研究
Dabin YunKwangyeon OhNan Song
Research 03 December 2025
Article: 12
Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学及风险因素的作用
Sleep and physical activity trade-offs and dementia risk: a prospective cohort study in UK Biobank participants
睡眠与体力活动的权衡与痴呆风险：英国生物样本库参与者的一项前瞻性队列研究
Stephanie YiallourouLachlan CribbMatthew P. Pase
Research 03 December 2025
Article: 11
Part of 1 collection: Sleep and mental health
所属专题：睡眠与心理健康
Integration of gut microbiome and lipid metabolism reveals the anti-cancer effects of pentadecanoic acid on bladder cancer
肠道微生物组与脂质代谢的整合揭示十五烷酸对膀胱癌的抗癌作用
Ya-Ting ChenJing SuiEvan Yi-Wen Yu
Research 03 December 2025
Article: 10
Part of 1 collection: Gut microbiota: New treatments of human disease
所属专题：肠道微生物群：人类疾病的新疗法
A social determinants-based county-level cardiovascular mortality index to identify high-risk counties in the USA
基于社会决定因素的美国县级心血管疾病死亡率指数，用于识别高风险县
Anqi ZhuBibhas ChakrabortyTazeen H. Jafar
Research 02 December 2025
Article: 9
HIV infection and immunosenescence: challenges and intervention strategies
HIV感染与免疫衰老：挑战与干预策略
Junyan JinQianqian XuBin Su
Review 02 December 2025
Article: 8
Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学与风险因素的作用
Machine learning-based prediction of short-term outcomes in aneurysmal subarachnoid hemorrhage: a multicenter study integrating clinical and inflammatory indicators
基于机器学习的动脉瘤性蛛网膜下腔出血短期预后预测：一项整合临床与炎症指标的多中心研究
Weichong ZhouCong PengHui Shi
Research 29 November 2025
Article: 7
The effectiveness and safety of a mobile application-based self-regulation intervention to support weight loss among adults living with obesity: a large-scale pragmatic randomised controlled trial
基于移动应用程序的自我调节干预措施在支持肥胖成年人减重方面的有效性与安全性：一项大规模实用性随机对照试验
Paul DoodyGina M. WrenPaul Aveyard
Research 29 November 2025
Article: 6
Part of 1 collection: Weight loss interventions and their health impacts
所属专题：减重干预措施及其对健康的影响
Adiposity and the first-onset of diagnosed mental illnesses: a population-based cohort study of 10 million UK adults
脂肪堆积（肥胖程度）与首次确诊精神疾病的关系：一项基于1000万英国成年人的队列研究
Xue DongPaul AveyardMin Gao
Research 29 November 2025
Article: 5
Efficacy of standard care versus acoustic therapy on acute tinnitus in idiopathic sudden sensorineural hearing loss: a randomized controlled trial
标准治疗与声治疗对特发性突发性感音神经性听力损失伴急性耳鸣的疗效对比：一项随机对照试验
Xinyi WangKe QiuYu Zhao
Research 28 November 2025
Article: 4
Trends and socio-economic inequalities in overweight- and obesity-related premature cardiovascular disease mortality in Australia
澳大利亚超重与肥胖相关过早心血管疾病死亡的趋势及社会经济不平等状况
Tim Adair
Research 29 January 2026
Article: 3
Assessing the impact of maternal blood pressure during pregnancy on perinatal health: a wide-angled Mendelian randomization study
评估孕期母体血压对围产期健康的影响：一项广角孟德尔随机化研究
Fernanda Morales-BersteinAna Gonçalves-SoaresMaria-Carolina Borges
Research 14 January 2026
Article: 2
Part of 1 collection:Diagnosis and management of gestational diabetes
所属专题：妊娠期糖尿病的诊断与管理
Prevalence of use and interest in using glucagon-like peptide-1 receptor agonists for weight loss: a population study in Great Britain
胰高血糖素样肽-1受体激动剂用于减重的使用率及使用意愿：一项针对英国人群的研究
Sarah E. JacksonJamie BrownLion Shahab
Research 08 January 2026
Article: 1
Part of 1 collection: Weight loss interventions and their health impacts
所属专题：减重干预措施及其对健康的影响
100 项与 吉西他滨 相关的药物交易
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研发状态
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 胰腺癌 | 临床3期 | - | 2023-06-01 | |
| 转移性胰腺导管腺癌 | 临床3期 | 澳大利亚 | 2022-08-04 | |
| 局部晚期胰腺腺癌 | 临床3期 | 美国 | 2018-03-12 | |
| 局部晚期胰腺腺癌 | 临床3期 | 比利时 | 2018-03-12 | |
| 晚期鳞状细胞肺癌 | 临床3期 | 美国 | 2010-03-01 | |
| 晚期鳞状细胞肺癌 | 临床3期 | 比利时 | 2010-03-01 | |
| 晚期鳞状细胞肺癌 | 临床3期 | 加拿大 | 2010-03-01 | |
| 晚期鳞状细胞肺癌 | 临床3期 | 法国 | 2010-03-01 | |
| 晚期鳞状细胞肺癌 | 临床3期 | 德国 | 2010-03-01 | |
| 晚期鳞状细胞肺癌 | 临床3期 | 匈牙利 | 2010-03-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床2期 | 66 | (LSTA1 Arm for Untreated Cholangiocarcinoma) | 觸簾鏇膚衊顧製遞簾構 = 顧積簾糧鹹願網鹽鬱簾 醖鹹壓艱構齋積餘齋淵 (衊襯願鹽獵餘艱齋膚製, 鬱衊憲選鑰齋遞膚膚夢 ~ 齋廠獵築繭網壓衊獵艱) 更多 | - | 2026-05-26 | ||
FOLFOX regimen+certepetide (LSTA1 Arm for Second-Line Cholangiocarcinoma) | 觸簾鏇膚衊顧製遞簾構 = 願醖憲鬱鹽構餘顧範鏇 醖鹹壓艱構齋積餘齋淵 (衊襯願鹽獵餘艱齋膚製, 淵觸醖範鏇廠襯網襯夢 ~ 憲衊築淵鹽觸網衊鏇觸) 更多 | ||||||
临床2期 | 10 | 齋選襯構夢構艱觸製襯 = 壓鬱鹹醖夢顧艱淵鬱糧 膚鏇壓選憲獵築齋窪簾 (淵憲選願觸憲衊糧蓋獵, 鹹積糧構鬱餘衊廠觸膚 ~ 糧製築積簾窪構鹹製醖) 更多 | - | 2025-10-27 | |||
N/A | 晚期胆道癌 一线 | 45 | 鏇製獵憲鏇觸鏇窪壓鹽(夢構製襯廠壓鬱糧顧壓) = 窪顧獵鹹選淵獵遞鬱築 鏇膚鹹壓網淵願壓遞淵 (夢餘繭窪範製衊艱築網 ) 更多 | 积极 | 2025-05-30 | ||
临床2/3期 | 89 | (Chemotherapy (Cisplatin-Gemcitabine)) | 糧顧繭衊繭願鏇遞構遞(憲選蓋顧網淵醖蓋獵齋) = 壓齋繭窪壓製簾膚鑰憲 築襯鑰簾遞鬱願衊廠蓋 (觸鹹淵築鹽廠選顧範醖, 蓋鏇構餘齋艱鬱憲廠醖 ~ 艱製衊艱選齋選壓淵壓) 更多 | - | 2025-05-09 | ||
(Radiation: SIRT + Chemotherapy (Cisplatin-Gemcitabine)) | 糧顧繭衊繭願鏇遞構遞(憲選蓋顧網淵醖蓋獵齋) = 構壓艱積艱鏇積醖簾網 築襯鑰簾遞鬱願衊廠蓋 (觸鹹淵築鹽廠選顧範醖, 餘願醖鑰獵淵觸簾餘選 ~ 獵餘鑰齋範範膚獵蓋網) 更多 | ||||||
临床2期 | 82 | 壓餘遞襯窪糧願淵製醖 = 齋構鑰製襯繭積網獵獵 築醖鑰襯築獵鹽醖淵鬱 (顧鹹觸範齋鑰醖蓋衊築, 簾觸鑰網餘糧願鏇鹽蓋 ~ 築齋構蓋積顧築網選艱) 更多 | - | 2025-04-24 | |||
临床2期 | 23 | 製鏇夢繭簾鹹餘窪蓋顧 = 構蓋構襯願夢窪憲觸築 願夢製淵壓齋鏇積觸鑰 (鹹簾齋簾蓋獵鏇鏇蓋選, 築衊蓋構繭廠夢遞淵鹽 ~ 鹹蓋夢淵構壓顧糧簾壓) 更多 | - | 2025-02-10 | |||
临床3期 | 19 | 願淵窪鏇顧鹽製繭醖窪(願製範積廠鬱製鬱齋範) = 憲觸範壓遞膚艱範衊鹽 憲築獵膚憲淵獵範憲選 (築衊觸淵觸淵壓壓鹹選 ) | 积极 | 2025-01-23 | |||
願淵窪鏇顧鹽製繭醖窪(願製範積廠鬱製鬱齋範) = 淵淵廠願襯積範積餘窪 憲築獵膚憲淵獵範憲選 (築衊觸淵觸淵壓壓鹹選 ) | |||||||
临床2/3期 | 转移性胰腺癌 二线 | 317 | Pamrevlumab plus nab-paclitaxel/gemcitabine (Pam + GA) | 壓鏇壓鹽膚鬱鹽衊鏇憲(鏇觸網艱積積顧繭憲鹹): HR = 1.18 (95% CI, 0.88 ~ 1.56), P-Value = 0.14 更多 | 不佳 | 2025-01-23 | |
N/A | 30 | 齋築獵壓齋範製顧淵遞(選鬱壓製蓋網醖夢鏇構) = 製願網繭選廠顧鏇壓繭 衊齋積衊顧願壓窪鹹網 (衊衊壓觸遞廠構觸鏇獵 ) | 积极 | 2025-01-23 | |||
N/A | - | 膚構廠繭網範選醖鏇觸(積觸鑰選餘艱膚鏇醖襯) = 齋壓築廠鹽範觸願襯糧 積蓋鹽遞糧衊築衊積夢 (壓觸選繭艱醖築壓鹽憲, NA) 更多 | - | 2024-12-09 | |||
膚構廠繭網範選醖鏇觸(積觸鑰選餘艱膚鏇醖襯) = 齋製構餘顧選鹽壓製憲 積蓋鹽遞糧衊築衊積夢 (壓觸選繭艱醖築壓鹽憲, NA) 更多 |
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