Hydroxychloroquine Sulfate

FRIDAY, March 28, 2025 -- As a measles outbreak spreads across U.S., doctors are now seeing a new and unexpected danger: Children getting sick from taking too much vitamin A. At Covenant Children’s Hospital in Lubbock, Texas, several unvaccinated children showed signs of liver problems after taking large amounts of vitamin A, according to Dr. Lara Johnson , the hospital’s chief medical officer. U.S. Department of Health and Human Services Secretary Robert F. Kennedy Jr . has promoted vitamin A during the outbreak, even suggesting it might help prevent measles . But doctors say this isn’t true. “If people have the mistaken impression that you have an either-or choice of MMR vaccine or vitamin A, you’re going to get a lot of kids unnecessarily infected with measles. That’s a problem, especially during an epidemic,” Dr. Peter Hotez , co-director of the Texas Children’s Hospital Center for Vaccine Development and dean of the National School of Tropical Medicine at Baylor College of Medicine, told CNN . “And second, you have this unregulated medicine in terms of doses being given and potential toxicities.” The measles, mumps and rubella (MMR) vaccine is the only proven way to prevent measles. It is 97% effective after two doses. Kennedy has said he encourages vaccines, but considers vaccination a personal choice. Vitamin A can be helpful for people with measles when given in the right dose by a doctor. But taking too much, especially without medical supervision, can be dangerous. Vitamin A is fat-soluble and can build up in the body. This can lead to dry skin, blurry vision, bone problems and liver damage. In pregnant women, it can even cause birth defects. Dr. Lesley Motheral , a pediatrician in Lubbock, said kids in Texas are generally well-nourished and don’t need extra vitamin A. “Recovery for patients with acute toxicity can be rapid when the vitamin is discontinued,” Motheral said. “Sadly, some of the more serious problems with vitamin A toxicity are not always reversible.” The Council for Responsible Nutrition (CRN), a group representing supplement makers, also warned parents not to give their children high doses of vitamin A. “While vitamin A plays an important role in supporting overall immune function, research hasn’t established its effectiveness in preventing measles infection. CRN is concerned about reports of high-dose vitamin A being used inappropriately, especially in children,” it said in a statement . Johnson said some parents may be following questionable advice from social media or health influencers. “It’s coming out of the health and wellness … influencer industry that downplays the importance of vaccines and tries to promote various spectacular cures like ivermectin or hydroxychloroquine or vitamin A,” Hotez added. In a recent interview with Fox News , Kennedy promoted a treatment plan that includes vitamin A, a steroid, an antibiotic and cod liver oil, but doctors say there’s little to no proof this works for measles. The measles outbreak has now affected at least 378 people in 17 states, from Texas and New Mexico to Vermont, New York and Washington. Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

SHANGHAI, March 26, 2025 /PRNewswire/ -- Shanghai Juncell Therapeutics Co., Ltd. (Juncell Therapeutics), a clinical-stage biotech developing innovative IL-2-independent Tumor-Infiltrating Lymphocyte (TIL) therapies for cancers, announced that a preclinical study of innovative pretreatment regimens for cell therapy will be presented at the American Association for Cancer Research (AACR) Annual Meeting, taking place April 25 - 30 in Chicago. This study indicated that hydroxychloroquine (HCQ) could significantly increase the tumor-killing effects via elevating the membrane MHC-I protein levels of tumor cells without affecting TILs'proliferation. In addition, its effect on surface PD-L1 expression was not significant compared with IFN-γ. These results provide preclinical evidence for HCQ pretreatment of the adoptive cell therapy of TILs in clinical trials. Details of the poster presentation are below: Abstract Number: 5827 Abstract Title: Hydroxychloroquine increases the tumor killing efficiency via elevating the membrane MHC-I protein levels of tumor cells Session Title: Immunomodulatory Agents and Interventions Location: Poster Section 29 Poster Board Number: 3 Poster Presentation Time: 2:00 PM - 5:00 PM CST, April 29, 2025 About Juncell Therapeutics Juncell Therapeutics is a biotech dedicated to developing high-quality, accessible TIL cell therapies for the treatment of solid tumors. Juncell Therapeutics has established its proprietary DeepTIL® cell expansion and NovaGMP® gene modification technology platforms, which are designed to address the key challenges of conventional TIL therapies, making TILs "robust, competent, affordable, and accessible." Two clinical-stage TIL therapies have demonstrated promising safety and efficacy in the treatment of ten types of heavily pretreated advanced solid tumors, including lung cancer, triple-negative breast cancer, pancreatic cancer, high-grade glioma, ovarian cancer, endometrial cancer, cervical cancer, head and neck cancer, bile duct cancer and melanoma. 7 of these late-stage tumor patients have achieved complete response, and the longest tumor-free survival time is over 3 years. For more information, please visit: Juncell Contact: [email protected] SOURCE Shanghai Juncell Therapeutics Co., Ltd. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED